Search

Historically, many transplant (HCT)-eligible patients have not reached HCT due to limited matched donors (especially racial/ethnic minorities) and disease progression. Advances now permit safer use of alternative donors, while best search strategy for a given patient is unclear. The BMT CTN 1702 trial used baseline unrelated donor search prognosis (SP: very likely with 8/8 MUD probability of > 90%, less likely 26% probability, and very unlikely < 10% probability) to guide strategy in a prospective national trial (top line results: similar HCT incidence per SP groups, EBMT 2023). We now share previously unreported data on donor search and selection strategy to achieve HCT, representing an unparalleled comprehensive examination of this process.

•Transplant rates differed by nonmalignant/malignant disease and children/adult patients.•Black/African American patients received transplants at a lower rate than white patients.•Good donor search prognosis score was associated with higher patient transplant rate.

Plastic Concrete is a low-strength (fcm,28d≤ 1.0 MPa), low-stiffness, impervious concrete used for cut-off wall construction in earthen dams. To date, there has been no systematic study on the effect of mix design on the long-term time development of the mechanical properties (compressive strength, tensile strength, and elastic modulus) of Plastic Concrete. Therefore currently no Plastic Concrete specific constitutive law for cut-off wall design exists. The present study closes this gap. Ten Plastic Concrete mixes with two bentonite-cement ratios and three types of sodium bentonite were produced. Fresh concrete workability tests were performed for all mixes. Compressive strength tests were performed at ages 28 d, 56 d, 91 d and four years. Splitting tensile strength and elastic modulus tests were performed at 28 days. The workability results show a good linear correlation between slump and flow table tests. Plastic Concrete’s compressive strength development over time is notably slower than that of ordinary concrete, and a new time development model following fibMC 2020 is established using a fitted sCcoefficient. The splitting tensile strength shows an overall good, linear correlation with compressive strength, with an approximate ratio of 0.135. Furthermore, the elastic modulus EC,Saccording to EN 12390-13 concrete tests show significantly higher elastic modulus than the available data, and a model approximation for the elastic modulus EC,Sas a function of compressive strength is also provided. Overall, this study provides the first Plastic Concrete specific mechanical property models, confirming the critical role mix design plays on Plastic Concrete’s short and long-term mechanical properties. Thus, the developed models enable a more realistic Plastic Concrete cut-off wall design and provide an important basis for future research.

We demonstrate the application of implanted-ion β-detected NMR as a probe of ionic liquid molecular dynamics through the measurement of 8Li spin-lattice relaxation (SLR) and resonance in 1-ethyl-3-methylimidazolium acetate. The motional narrowing of the resonance and the local maxima in the SLR rate, 1/T1, imply sensitivity to subnanosecond Li+solvation dynamics. From an analysis of 1/T1, we extract an activation energy EA= 74.8(1.5) meV and Vogel–Fulcher–Tammann constant TVFT= 165.8(0.9) K, in agreement with the dynamic viscosity of the bulk solvent. Near the melting point, the lineshape is broad and intense, and the form of the relaxation is nonexponential, reflective of our sensitivity to heterogeneous dynamics near the glass transition. The depth resolution of this technique may later provide a unique means of studying nanoscale phenomena in ionic liquids.

Gold nanoparticles (AuNPs) have been a subject of considerable interest in recent years due to both their magnetic and catalytic properties. This paper reports a two-fold study of the reactivity at 300 K of the isotopic hydrogen atom, muonium (Mu = μ+e–), (i) with bare uncappedAuNPs of different sizes encapsulated in mesoporous (SBA-15) silica hosts, forming a diamagnetic final state in the Mu + AuNP → MuAuNP reaction, and (ii) with surface-adsorbed benzene on these NPs forming the muoniated cyclohexadienyl radical in the Mu + C6H6→ MuĊ6H6addition reaction. The measured muon-spin relaxation rates, λC, for the chemisorption reaction of Mu with the bare AuNPs show some variation with AuNP size. The Mu + C6H6addition reaction has been studied over a range of benzene loadings both on bare silica and in the AuNP/silica samples. The measured muon-spin relaxation rates, λTot, exhibit a linear dependence on benzene concentration over the full range of loadings in both cases, in accord with an Eley–Rideal model of surface reactivity. Rate constants, kBz, were determined from this dependence which exhibit a 2–3-fold faster reaction rate on the AuNPs than on the bare silica, suggesting a catalytic effect due to benzene adsorbed on these NP surfaces.

CD34+ cell dose is critical for cord blood (CB) engraftment. However, the CD34+ content of the CB inventory in the United States is unknown. We examined the CD34+ cell content of 126 341 red blood cell–depleted US units banked from January 2007 to September 2017 with a total nucleated cell (TNC) count of ≥90 × 107 and a cryovolume of 24-55 mL. Median pre-cryopreservation TNC content was 127 × 107 (interquartile range [IQR], 108-156 × 107); CD34+ cell content was 44 × 105 (IQR, 29 to 67 × 105). The median CD34+:TNC ratio was 0.34%. TNC and CD34+ cell content correlation was weak (r = 0.24). Of 7125 units with TNCs of ≥210 × 107, only 47% had CD34+ content of ≥100 × 105. However, some units had high CD34+ content for a given TNC count. Only 4% of CB units were acceptable as single-unit grafts (TNCs, ≥2.5 × 107/kg; CD34+ cells, ≥1.5 × 105/kg) for 70-kg patients; 22% of units were adequate for 70-kg patients using lower dose criteria (TNCs, ≥1.5 × 107/kg; CD34+ cells, ≥1.0 × 105/kg) suitable for a double-unit graft. These findings highlight that units with the highest TNC dose may not have the highest CD34+ dose, units with unexpectedly high CD34+ content (a ratio of >1.0%) should be verified, and the US CB inventory of adequately sized single units for larger patients is small. They also support the ongoing use of double-unit grafts, a focus on banking high-dose units, and development of expansion technologies.

CD34+cell dose is critical for cord blood (CB) engraftment. However, the CD34+content of the CB inventory in the United States is unknown. We examined the CD34+cell content of 126 341 red blood cell–depleted US units banked from January 2007 to September 2017 with a total nucleated cell (TNC) count of ≥90 × 107and a cryovolume of 24-55 mL. Median pre-cryopreservation TNC content was 127 × 107(interquartile range [IQR], 108-156 × 107); CD34+cell content was 44 × 105(IQR, 29 to 67 × 105). The median CD34+:TNC ratio was 0.34%. TNC and CD34+cell content correlation was weak (r= 0.24). Of 7125 units with TNCs of ≥210 × 107, only 47% had CD34+content of ≥100 × 105. However, some units had high CD34+content for a given TNC count. Only 4% of CB units were acceptable as single-unit grafts (TNCs, ≥2.5 × 107/kg; CD34+cells, ≥1.5 × 105/kg) for 70-kg patients; 22% of units were adequate for 70-kg patients using lower dose criteria (TNCs, ≥1.5 × 107/kg; CD34+cells, ≥1.0 × 105/kg) suitable for a double-unit graft. These findings highlight that units with the highest TNC dose may not have the highest CD34+dose, units with unexpectedly high CD34+content (a ratio of >1.0%) should be verified, and the US CB inventory of adequately sized single units for larger patients is small. They also support the ongoing use of double-unit grafts, a focus on banking high-dose units, and development of expansion technologies.