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Hearty and Tormey (1) challenge our conclusions (2), incorrectly arguing that the megaboulders we discuss were shown to originate from the cliff bottom. A number of mischaracterizations are made by Hearty and Tormey (1) in their letter. First, we do not use a “tsunami wave model.” Second, we do not address the two other Bahamian landforms Hearty and Tormey (1) mention: their “superstorm” genesis interpretation [for which alternative hypotheses have been proposed (3, 4)] has no bearing on our (2) conclusions. Hearty and Tormey’s (1) claim that the boulders have “fingerprints” based on “several physical criteria” and “data from multiple disciplines” is false. Only two mega-boulder “physical properties” were reported by Hearty … [↵][1]1To whom correspondence should be addressed. Email: arovere{at}marum.de. [1]: #xref-corresp-1-1

Background Health information technology (HIT), such as electronic health records (EHRs), is a growing part of the clinical landscape. Recent studies among physicians suggest that HIT is associated with a higher prevalence of burnout. Few studies have investigated the workflow and practice-level predictors of burnout among advanced practice registered nurses (APRNs). Aim Characterize HIT use and measure associations between EHR-related stress and burnout among APRNs. Methods An electronic survey was administered to all APRNs licensed in Rhode Island, United States (N = 1197) in May–June 2017. The dependent variable was burnout, measured with the validated Mini z burnout survey. The main independent variables were three EHR-related stress measures: time spent on the EHR at home, daily frustration with the EHR, and time for documentation. Logistic regression was used to measure the association between EHR-related stress and burnout before and after adjusting for demographics, practice-level characteristics, and the other EHR-related stress measures. Results Of the 371 participants, 73 (19.8%) reported at least one symptom of burnout. Among participants with an EHR (N = 333), 165 (50.3%) agreed or strongly agreed that the EHR added to their daily frustration and 97 (32.8%) reported an insufficient amount of time for documentation. After adjustment, insufficient time for documentation (AOR = 3.72 (1.78–7.80)) and the EHR adding to daily frustration (AOR = 2.17 (1.02–4.65)) remained predictors of burnout. Conclusions Results from the present study revealed several EHR-related environmental factors are associated with burnout among APRNs. Future studies may explore the impact of addressing these EHR-related factors to mitigate burnout among this population.

We use 2.0 Msec of Chandra observations to investigate the cocoon shocks of Cygnus A and some implications for its lobes and jet. Measured shock Mach numbers vary in the range 1.18-1.66 around the cocoon. We estimate a total outburst energy of $\simeq 4.7\times10^{60}\rm\ erg$, with an age of $\simeq 2 \times 10^{7}\rm\ yr$. The average postshock pressure is found to be $8.6 \pm 0.3 \times 10^{-10}\rm\ erg\ cm^{-3}$, which agrees with the average pressure of the thin rim of compressed gas between the radio lobes and shocks, as determined from X-ray spectra. However, average rim pressures are found to be lower in the western lobe than in the eastern lobe by $\simeq 20\%$. Pressure estimates for hotspots A and D from synchrotron self-Compton models imply that each jet exerts a ram pressure $\gtrsim$ 3 times its static pressure, consistent with the positions of the hotspots moving about on the cocoon shock over time. A steady, one-dimensional flow model is used to estimate jet properties, finding mildly relativistic flow speeds within the allowed parameter range. Models in which the jet carries a negligible flux of rest mass are consistent with with the observed properties of the jets and hotspots. This favors the jets being light, implying that the kinetic power and momentum flux are carried primarily by the internal energy of the jet plasma rather than by its rest mass., Comment: Accepted to ApJ, 15 pages, 7 figures, 4 tables

This paper presents the analysis of Chandra X-ray snapshot observations of a subsample of the extragalactic sources listed in the revised Third Cambridge radio catalog (3CR), previously lacking X-ray observations and thus observed during Chandra Cycle 15. This data set extends the current Chandra coverage of the 3CR extragalactic catalog up to redshift $z$=1.0. Our sample includes 22 sources consisting of one compact steep spectrum (CSS) source, three quasars (QSOs), and 18 FR\,II radio galaxies. As in our previous analyses, here we report the X-ray detections of radio cores and extended structures (i.e., knots, hotspots and lobes) for all sources in the selected sample. We measured their X-ray intensities in three energy ranges: soft (0.5--1 keV), medium (1--2 keV) and hard (2-7 keV) and we also performed standard X-ray spectral analysis for brighter nuclei. All radio nuclei in our sample have an X-ray counterpart. We also discovered X-ray emission associated with the eastern knot of 3CR\,154, with radio hotspots in 3CR\,41, 3CR\,54 and 3CR\,225B and with the southern lobe of 3CR\,107. Extended X-ray radiation around the nuclei 3CR\,293.1 and 3CR\,323 on a scale of few tens kpc was also found. X-ray extended emission, potentially arising from the hot gas in the intergalactic medium and/or due to the high energy counterpart of lobes, is detected for 3CR\,93, 3CR\,154, 3CR\,292 and 3CR\, 323 over a few hundreds kpc-scale. Finally, this work also presents an update on the state-of-the-art of Chandra and XMM-Newton observations for the entire 3CR sample., Comment: 25 pages, 6 tables, 27 figures, ApJS accepted for publication (pre-proof version)

Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric TCRs or synthetic chimeric Ag receptors (CARs). TCRs recognize peptide-HLA complexes whereas CARs typically use an Ab-derived single-chain fragments variable that recognizes cancer-associated cell-surface Ags. Although both receptors mediate diverse effector functions, a quantitative comparison of the sensitivity and signaling capacity of TCRs and CARs has been limited due to their differences in affinities and ligands. In this study we describe their direct comparison by using TCRs that could be formatted either as conventional αβ heterodimers, or as single-chain fragments variable constructs linked to CD3ζ and CD28 signaling domains or to CD3ζ alone. Two high-affinity TCRs (KD values of ∼50 and 250 nM) against MART1/HLA-A2 or WT1/HLA-A2 were used, allowing MART1 or WT1 peptide titrations to easily assess the impact of Ag density. Although CARs were expressed at higher surface levels than TCRs, they were 10–100-fold less sensitive, even in the absence of the CD8 coreceptor. Mathematical modeling demonstrated that lower CAR sensitivity could be attributed to less efficient signaling kinetics. Furthermore, reduced cytokine secretion observed at high Ag density for both TCRs and CARs suggested a role for negative regulators in both systems. Interestingly, at high Ag density, CARs also mediated greater maximal release of some cytokines, such as IL-2 and IL-6. These results have implications for the next-generation design of receptors used in adoptive T cell therapies.

Control of quantum dot (QD) precursor chemistry has been expected to help improve the size control and uniformity of III-V QDs such as indium phosphide and indium arsenide. Indeed, experimental results for other QD systems are consistent with the theoretical prediction that the rate of precursor conversion is an important factor controlling QD size and size distribution. We synthesized and characterized the reactivity of a variety of group-V precursors in order to determine if precursor chemistry could be used to improve the quality of III-V QDs. Despite slowing down precursor conversion rate by multiple orders of magnitude, the less reactive precursors do not yield the expected increase in size and improvement in size distribution. This result disproves the widely accepted explanation for the shortcoming of current III-V QD syntheses and points to the need for a new generalizable theoretical picture for the mechanism of QD formation and growth.

As a student at St Edward's School, Kenneth Grahame excelled at Greek and Latin and later acknowledged the formative, “paganizing” effect of his classical education on his worldview.1Grahame wrote:...

We report that trace amounts of water impurities in indium myristate precursors can negatively impact indium phosphide nanoparticle growth by limiting its size tunability. Without water, the growth can be effectively tuned by growth temperature and time with the first absorption peak reaching 620 nm; with water, the growth presents a “focused” behavior with the first absorption peak remaining around 550 nm. The results imply that water impurities, either from indium acetate derived indium precursors or generated in situ during nanoparticle growth, may be the cause of the currently observed inhibited growth behavior of indium phosphide quantum dots. We use multistage microfluidic reactors to show that this inhibiting effect occurs at the late stage of particle growth, following precursor depletion. We extend our study by showing that trace amounts of free hydroxide can also inhibit nanoparticle growth. We attribute the inhibited growth behavior to the hydroxylation effect of water or free hydroxide.

‘‘A confrontation with Nietzsche is a difficult thing to arrange.’’ So writes Philippa Foot, whose own important confrontations with Nietzsche focused largely on his views concerning human virtue, goodness and flourishing. Nietzsche is a difficult philosopher to engage because, perhaps owing to the varied styles, tensions, and developments in his views, it can be difficult as readers to get a handle on just what Nietzsche is up to. Is he tearing down, or building up? Is he serious, or satirical? And if we say that he is all of these things, then we must ask how, in a principled way, we should draw lines between these and other strategies in a given work, or passage. Nietzsche’s views on virtue serve as an example of these challenges. In part seven of Beyond Good and Evil, ‘‘Our Virtues,’’ Nietzsche begins not with an explanation or proclamation, but with a question

The application of low melt alloys (LMAs) containing In, Ga, Sn, and Bi as compliant high performance thermal interface material (TIM) is investigated. The investigation described herein involves in situ thermal performances of the LMAs as a function of applied pressure and interface temperature, performance evaluation after accelerated life cycle testing, and guidelines to improve the cycle life. Testing methodologies follow ASTM D5470 protocols, and measurements are validated by testing well established, commercially available TIMs and comparisons are made to values reported in open literature as well as manufacturers’ data. Measurement shows that LMAs can offer thermal interfacial resistances as low as 0.005 cm 2 °C/W, and their performance is highly contingent upon the quality of the mating surfaces. The issue of LMA containment and dewetting are discussed along with the solutions to mitigate them.

Waves are the main hydrodynamic force acting on coral reefs and are crucial in driving the evolution of reef systems. Previous research has mainly focused on wave breaking and transformation on the reef flat but often neglected the spatial variation of reformed wave characteristics once they have propagated into the back-reef environment. This study examines wave conditions on a reef flat and the adjacent back-reef sand apron specifically focusing on the transformation of wave height, period and spectra (including changes to long-period and incident wave height). The ability of reformed waves in the back-reef environment to entrain sediment is also investigated. Wave conditions were found to be distinctly different on the sand apron compared to the reef flat, with the majority of wave energy dissipated during initial breaking and transformation. Almost all incident waves are dissipated on the reef flat under a depth threshold of 0.5 m before reaching the back-reef with long-period motions dominating in the back-reef during these tidal stages. At higher tidal stages incident waves are capable of propagating into the back reef but they are very low energy with under 1% of all waves capable of entraining sediment. This suggests that higher energy events, such as high frequency storms, are required to significantly transport sediment and change reef geomorphology. Smaller scale spatial changes in wave height were observed on the sand apron that shows the influence of both cross- and along-reef attenuation processes. A distance parameter ( X pd ) is introduced that combines the cross-reef distance from the reef crest ( X d ) and the temporally specific along-reef distance from the first point of wave breaking on the reef rim ( X p , where X pd = X d + X p ). X pd is shown to accurately describe the changes in wave height and sediment entrainment if deep water significant wave height, wave direction, and depth over the reef flat are known. The results in this study shows that wave conditions, sediment entrainment, and longer term trends in sediment characteristics can be predicted in back-reef environments from a few simple geomorphic inputs.

Relative sea-level rise has been a major factor driving the evolution of reef systems during the Holocene. Most models of reef evolution suggest that reefs preferentially grow vertically during rising sea level then laterally from windward to leeward, once the reef flat reaches sea level. Continuous lagoonal sedimentation ("bucket fill") and sand apron progradation eventually lead to reef systems with totally filled lagoons. Lagoonal infilling of One Tree Reef (southern Great Barrier Reef) through sand apron accretion was examined in the context of late Holocene relative sea-level change. This analysis was conducted using sedimentological and digital terrain data supported by 50 radiocarbon ages from fossil microatolls, buried patch reefs, foraminifera and shells in sediment cores, and recalibrated previously published radiocarbon ages. This data set challenges the conceptual model of geologically continuous sediment infill during the Holocene through sand apron accretion. Rapid sand apron accretion occurred between 6000 and 3000 calibrated yr before present B.P. (cal. yr B.P.); followed by only small amounts of sedimentation between 3000 cal. yr B.P. and present, with no significant sand apron accretion in the past 2 k.y. This hiatus in sediment infill coincides with a sea-level fall of ~1-1.3 m during the late Holocene (ca. 2000 cal. yr B.P.), which would have caused the turn-off of highly productive live coral growth on the reef flats currently dominated by less productive rubble and algal flats, resulting in a reduced sediment input to backreef environments and the cessation in sand apron accretion. Given that relative sea-level variations of ~1 m were common throughout the Holocene, we suggest that this mode of sand apron development and carbonate production is applicable to most reef systems.

We study the dielectric constant of lead sulfide quantum dot (QD) films as a function of the volume fraction of QDs by varying the QD size and keeping the ligand constant. We create a reliable QD sizing curve using small-angle X-ray scattering (SAXS), thin-film SAXS to extract a pair-distribution function for QD spacing, and a stacked-capacitor geometry to measure the capacitance of the thin film. Our data support a reduced dielectric constant in nanoparticles.

Native Americans from the Amazon, Andes, and coast regions of South America have a rich cultural heritage, but have been genetically understudied leading to gaps in our knowledge of their genomic architecture and demographic history. Here, we sequenced 150 high-coverage and genotyped 130 genomes from Native American and mestizo populations in Peru. A majority of our samples possess greater than 90% Native American ancestry and demographic modeling reveals, consistent with a rapid peopling model of the Americas, that most of Peru was peopled approximately 12,000 years ago. While the Native American populations possessed distinct ancestral divisions, the mestizo groups were admixtures of multiple Native American communities which occurred before and during the Inca Empire. The mestizo communities also show Spanish introgression only after Peruvian Independence. Thus, we present a detailed model of the evolutionary dynamics which impacted the genomes of modern day Peruvians.

As global climate warms and sea level rises, coastal areas will be subject to more frequent extreme flooding and hurricanes. Geologic evidence for extreme coastal storms during past warm periods has the potential to provide fundamental insights into their future intensity. Recent studies argue that during the Last Interglacial (MIS 5e, ∼128–116 ka) tropical and extratropical North Atlantic cyclones may have been more intense than at present, and may have produced waves larger than those observed historically. Such strong swells are inferred to have created a number of geologic features that can be observed today along the coastlines of Bermuda and the Bahamas. In this paper, we investigate the most iconic among these features: massive boulders atop a cliff in North Eleuthera, Bahamas. We combine geologic field surveys, wave models, and boulder transport equations to test the hypothesis that such boulders must have been emplaced by storms of greater-than-historical intensity. By contrast, our results suggest that with the higher relative sea level (RSL) estimated for the Bahamas during MIS 5e, boulders of this size could have been transported by waves generated by storms of historical intensity. Thus, while the megaboulders of Eleuthera cannot be used as geologic proof for past “superstorms,” they do show that with rising sea levels, cliffs and coastal barriers will be subject to significantly greater erosional energy, even without changes in storm intensity.

We present arc-second-resolution data in the radio, IR, optical and X-ray for 4C+19.44 (=PKS 1354+195), the longest and straightest quasar jet with deep X-ray observations. We report results from radio images with half to one arc-second angular resolution at three frequencies, plus HST and Spitzer data. The Chandra data allow us to measure the X-ray spectral index in 10 distinct regions along the 18 arcsec jet and compare with the radio index. The radio and X-ray spectral indices of the jet regions are consistent with a value of $\alpha =0.80$ throughout the jet, to within 2 sigma uncertainties. The X-ray jet structure to the south extends beyond the prominent radio jet and connects to the southern radio lobe, and there is extended X-ray emission in the direction of the unseen counter jet and coincident with the northern radio lobe. This jet is remarkable since its straight appearance over a large distance allows the geometry factors to be taken as fixed along the jet. Using the model of inverse Compton scattering of the cosmic microwave background (iC/CMB) by relativistic electrons, we find that the magnetic field strengths and Doppler factors are relatively constant along the jet. If instead the X-rays are synchrotron emission, they must arise from a population of electrons distinct from the particles producing the radio synchrotron spectrum., Comment: Accepted for ApJ

We integrate heterogeneous terminologies into our category-theoretic model of faceted browsing and show that existing terminologies and vocabularies can be reused as facets in a cohesive, interactive system. Commonly found in online search engines and digital libraries, faceted browsing systems depend upon one or more taxonomies which outline the structure and content of the facets available for user interaction. Controlled vocabularies or terminologies are often curated externally and are available as a reusable resource across systems. We demonstrated previously that category theory can abstractly model faceted browsing in a way that supports the development of interfaces capable of reusing and integrating multiple models of faceted browsing. We extend this model by illustrating that terminologies can be reused and integrated as facets across systems with examples from the biomedical domain. Furthermore, we extend our discussion by exploring the requirements and consequences of reusing existing terminologies and demonstrate how categorical operations can create reusable groupings of facets.

BackgroundThe metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (> 20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. Fatty acid desaturase (FADS) 1 and 2 catalyze the rate-limiting steps in the biosynthesis of LC-PUFAs. TheFADSregion contains two haplotypes; ancestral and derived, where the derived haplotypes are associated with more efficient LC-PUFA biosynthesis and is nearly fixed in Africa. In addition, Native American populations appear to be nearly fixed for the lesser efficient ancestral haplotype, which could be a public health problem due to associated low LC-PUFA levels, while Eurasia is polymorphic. This haplotype frequency distribution is suggestive of archaic re-introduction of the ancestral haplotype to non-African populations or ancient polymorphism with differential selection patterns across the globe. Therefore, we tested theFADSregion for archaic introgression or ancient polymorphism. We specifically addressed the genetic architecture of theFADSregion in Native American populations to better understand this potential public health impact.ResultsWe confirmed Native American ancestry is nearly fixed for the ancestral haplotype and is under positive selection. The ancestral haplotype frequency is also correlated to Siberian populations’ geographic location further suggesting the ancestral haplotype’ s role in cold weather adaptation and leading to the high haplotype frequency within Native American populations’. We also find that the Neanderthal is more closely related to the derived haplotypes while the Denisovan clusters closer to the ancestral haplotypes. In addition, the derived haplotypes have a time to the most recent common ancestor of 688,474 years ago which is within the range of the modern-archaic hominin divergence.ConclusionsThese results support an ancient polymorphism forming in theFADSgene region with differential selection pressures acting on the derived and ancestral haplotypes due to the old age of the derived haplotypes and the ancestral haplotype being under positive selection in Native American ancestry populations. Further, the near fixation of the less efficient ancestral haplotype in Native American ancestry suggests the need for future studies to explore the potential health risk of associated low LC-PUFA levels in Native American ancestry populations.

Objectives. To evaluate the positive predictive value of machine learning algorithms for early assessment of adverse birth risk among pregnant women as a means of improving the allocation of social services. Methods. We used administrative data for 6457 women collected by the Illinois Department of Human Services from July 2014 to May 2015 to develop a machine learning model for adverse birth prediction and improve upon the existing paper-based risk assessment. We compared different models and determined the strongest predictors of adverse birth outcomes using positive predictive value as the metric for selection. Results. Machine learning algorithms performed similarly, outperforming the current paper-based risk assessment by up to 36%; a refined paper-based assessment outperformed the current assessment by up to 22%. We estimate that these improvements will allow 100 to 170 additional high-risk pregnant women screened for program eligibility each year to receive services that would have otherwise been unobtainable. Conclusions. Our analysis exhibits the potential for machine learning to move government agencies toward a more data-informed approach to evaluating risk and providing social services. Overall, such efforts will improve the efficiency of allocating resource-intensive interventions.

Samples of fine-grain, transparent polycrystalline alumina (CeraNova Corp) and multispectral zinc sulfide (Cleartran) were tested to determine mechanical strength and slow crack growth parameters. Mechanical strength measurements of coupons were fit to a Weibull equation that describes the material strength and its distribution. Slow crack growth parameters were calculated using the procedure set forth by Weiderhorn. 1 This paper describes the derivation of Weibull and slow crack growth parameters from strength measurements over a range of stress rates and how these parameters are used to predict window lifetime under stress. Proof testing is employed to ensure that a window begins its life with a known, minimum strength.

This tutorial paper explains the maximum likelihood method for Weibull analysis of mechanical strength of ceramic materials and how strength scales with area under stress. Weibull parameters for a variety of infrared window materials are presented. Calculation of the Weibull static probability of survival is illustrated.

Transparent ceramics are finding increasing use in optical applications with demanding operating conditions. Polycrystalline ceramics provide a unique combination of mechanical, dielectric and optical properties for sensor window applications that were previously not possible. The mechanical strength of CeraNova’s transparent alumina and spinel was measured by an equibiaxial strength test method. The results of the tests and their analysis, included those at elevated temperatures for transparent alumina, will be presented.

This study describes the interfacial thermal performance of low melting temperature alloys (LMAs) for the application as thermal interface materials (TIMs). The thermal performance of LMAs evaluated in terms of accelerated life cycle testing, which included highly accelerated stress testing (HAST) at 85oC and 85%RH and thermal cycling from −40°C to +125°C. Three lead and cadmium free low melting alloys (75.5Ga &24.5In, 100Ga, and 51In, 32.5Bi &16.5Sn) were tested as candidate LMAs. ASTM D 5470 testing methodologies were used to evaluate thermal performance of LMAs as well as some commercial TIMs (greases, phase change materials). Results showed that the proposed alloys survived 960 hours of highly accelerated stress testing (85°C and 85% RH) and 500 cycles from −40°C to +125°C without significant performance degradation.

We integrate heterogeneous terminologies into our category-theoretic model of faceted browsing and show that existing terminologies and vocabularies can be reused as facets in a cohesive, interactive system. Commonly found in online search engines and digital libraries, faceted browsing systems depend upon one or more taxonomies which outline the structure and content of the facets available for user interaction. Controlled vocabularies or terminologies are often externally curated and are available as a reusable resource across systems. We demonstrated previously that category theory can abstractly model faceted browsing in a way that supports the development of interfaces capable of reusing and integrating multiple models of faceted browsing. We extend this model by illustrating that terminologies can be reused and integrated as facets across systems with examples from the biomedical domain.

For in vivo imaging, the short-wavelength infrared region (SWIR; 1000–2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.

We discuss informatics-based challenges of constructing large-scale collaborative networks for healthcare research and analysis from rural community health centers. These types of networks provide data access and analytic insights across multiple heterogeneous health centers for both healthcare professionals and biomedical researchers. Challenges fall into three general categories: data access, data integration, and technical infrastructure. Data access issues arise in balancing patient privacy, security, and utility; data integration issues persist from each site independently operating its desired electronic medical record; technical infrastructure challenges include creating an analysis and reporting hub capable of scaling across a large collaborative network. Other challenges, such as the difficulty of site recruitment, are important to discuss, but cannot be solved directly through informatics alone. We discuss these challenges and their potential solutions in the context of our implementation of the Kentucky Diabetes and Obesity Collaborative (KDOC). KDOC is a network of Federally-Qualified Community Health Centers (FQHCs) that established a collaborative infrastructure for research and analysis of obesity and diabetes in rural and under-served communities.

We demonstrate that closure tables are an effective data structure for developing database-driven applications that query biomedical ontologies and that require cross-querying between multiple ontologies. A closure table stores all available paths within a tree, even those without a direct parent-child relationship; additionally, a node can have multiple ancestors which gives the foundation for supporting linkages between controlled ontologies. We augment the meta-data structure of the ICD9 and ICD10 ontologies included in i2b2, an open source query tool for identifying patient cohorts, to utilize a closure table. We describe our experiences in incorporating existing mappings between ontologies to enable clinical and health researchers to identify patient populations using the ontology that best matches their preference and expertise.

Philosophers of language inspired by Grice have long sought to show how facts about reference boil down to facts about speakers’ communicative intentions. I focus on a recent attempt by Stephen Neale (2016), who argues that referring with an expression requires having a special kind of communicative intention—one that involves representing an occurrence of the expression as standing in some particular relation to its referent. Neale raises a problem for this account: because some referring expressions are unpronounced, most language users don’t realize they exist, and so seemingly don’t have intentions about them. Neale suggests that we might solve this problem by supposing that speakers have nonconscious or “tacit” intentions. I argue that this solution can’t work by arguing that our representations of unpronounced bits of language all occur within a modular component of the mind, and so we can’t have intentions about them. From this line of thought, I draw several conclusions. (i) The semantic value of a referring expression is not its referent, but rather a piece of partial and defeasible evidence about what a speaker refers to when using it literally. (ii) There is no interesting sense in which speakers refer with expressions; referring expressions are used to give evidence about the sort of singular proposition one intends to communicate. (iii) The semantics–pragmatics interface is coincident with the interface between the language module and central cognition.

We propose a novel technique to measure the small-scale three-dimensional features of a shallow-water coral reef using a small drone equipped with a consumer-grade camera, a handheld GPS and structure from motion (SfM) algorithms. We used a GoPro HERO4 with a modified lens mounted on a DJI Phantom 2 drone (maximum total take-off weight

This paper investigates the mechanics of sediment transport on a subtidal sand apron located on a coral reef environment. In this environment 100% of the sediment is carbonate bioclasts generated in situ. The sand apron is located on the back reef and only affected by waves during high tides. It is commonly accepted in the literature that sand aprons are features that prograde lagoonwards and that most of the progradation occurs during high-energy events. Measurements of water depths, waves, currents and near bed suspended sediment concentrations (all at 10. Hz) on the sand apron were undertaken over a nine day intensive field campaign over both spring and neap tides; waves and tides were also measured in the lagoon. The topography and bathymetry of the sand apron were measured and mixing depth was obtained on three transects using depth of disturbance rods. We found that sediment transport on sand aprons is not solely restricted to high-energy events but occurs on a daily basis during spring tides. The main factor controlling the sediment transport was the water depth above the bed, with depths of 2-2.3. m allowing waves to promote the most sediment transport. This corresponds to a depth over the reef crest of 1.6-1.9. m. The second most important control was waves; transport was observed when H on the apron was 0.1. m or greater. In contrast, current magnitude was not a controlling mechanism for sediment entrainment but did affect sediment transport. The morphology of the sand apron was shown to affect the direction of currents with the currents also expected to influence the morphology of the sand apron. The currents measured during this field campaign were aligned with a shallow channel in the sand apron. Mixing depths were small (< 2.5. cm) yet they were larger than the values predicted by empirical formulae for gentle siliciclastic ocean beaches.

Back-reef sand aprons are conspicuous and dynamic sedimentary features in coral reef systems. The development of these features influences the evolution and defines the maturity of coral reefs. However, the hydrodynamic processes that drive changes on sand aprons are poorly understood with only a few studies directly assessing sediment entrainment and transport. Current and wave conditions on a back-reef sand apron were measured during this study and a digital elevation model was developed through topographic and bathymetric surveying of the sand apron, reef flats and lagoon. The current and wave processes that may entrain and transport sediment were assessed using second order small amplitude (Stokes) wave theory and Shields equations. The morphodynamic interactions between current flow and geomorphology were also examined. The results showed that sediment transport occurs under modal hydrodynamic conditions with waves the main force entraining sediment rather than average currents. A morphodynamic relationship between current flow and geomorphology was also observed with current flow primarily towards the lagoon in shallow areas of the sand apron and deeper channel-like areas directing current off the sand apron towards the lagoon or the reef crest. These results show that the short-term mutual interaction of hydrodynamics and geomorphology in coral reefs can result in morphodynamic equilibrium.

The chemokine CXCL10/IP-10 facilitates recruitment of Th1-type leukocytes to inflammatory sites. In this study, we show that the arginine methyltransferase PRMT5 is critical for CXCL10 transcription in TNF-α-activated human endothelial cells (EC). We found that depletion of PRMT5 results in significantly reduced levels of CXCL10 mRNA, demonstrating a positive role for PRMT5 in CXCL10 induction. Chromatin immunoprecipitation experiments revealed the presence of the symmetrical dimethylarginine modification catalyzed by PRMT5 associated with the CXCL10 promoter in response to TNF-α. However, symmetrical dimethylarginine-modified proteins were not detected at the promoter in the absence of PRMT5, indicating that PRMT5 is essential for methylation to occur. Furthermore, NF-κB p65, a critical driver of TNF-α-mediated CXCL10 induction, was determined to be methylated at arginine residues. Crucially, RNAi-mediated PRMT5 depletion abrogated p65 methylation and CXCL10 promoter binding. Mass spectrometric analysis in EC identified five dimethylated arginine residues in p65, four of which are uncharacterized in the literature. Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression. In conclusion, we have identified previously uncharacterized p65 post-translational modifications critical for CXCL10 induction.

Faceted browsing has become ubiquitous with modern digital libraries and online search engines, yet the process is still difficult to abstractly model in a manner that supports the development of interoperable and reusable interfaces. We propose category theory as a theoretical foundation for faceted browsing and demonstrate how the interactive process can be mathematically abstracted. Existing efforts in facet modeling are based upon set theory, formal concept analysis, and light-weight ontologies, but in many regards, they are implementations of faceted browsing rather than a specification of the basic, underlying structures and interactions. We will demonstrate that category theory allows us to specify faceted objects and study the relationships and interactions within a faceted browsing system. Resulting implementations can then be constructed through a category-theoretic lens using these models, allowing abstract comparison and communication that naturally support interoperability and reuse.

Violent extremist organizations differ from other ideologically based groups that do not necessarily meet formal criteria to be considered organizations, and distinguishing between these types of collective arrangements is critical in understanding their strengths and weaknesses. We identified three arrangements of individuals with varying levels of sophistication: groups, simple organizations, and complex organizations. Each arrangement is discussed in terms of its influence on fundraising, recruiting, and attack execution, with particular emphasis being placed on exemplars from the white supremacist ideology. Despite their shared ideology, white supremacists illustrate marked performance-related differences that are influenced by organizational factors such as leadership, structure, and formalization. Analyzing those differences led us to conclude that organizations are unique from groups, different structures are best suited for certain strategies, leadership matters a great deal in the context of viol...

A 50:50 vol% MgO–Y2O3 nanocomposite with ~150 nm grain size was prepared in an attempt to make 3–5 lm infraredtransmitting windows with increased durability and thermal shock resistance. Flexure strength of the composite at 21° Ci s 679 MPa for 0.88 cm 2 under load. Hardness is consistent with that of the constituents with similar grain size. For 3-mm-thick material at 4.85 lm, the total scatter loss is 1.5%, forward scatter is 0.2%, and absorptance is 1.8%. Optical scatter below 2 lm is 100%. Variable intensity OH absorption (~6% absorptance) is observed near 3 lm. The refractive index is ~0.4% below the volume-fraction-weighted average of those of the constituents. Thermal expansion is equal to the volumefraction-weighted average of expansion of the constituents. Specific heat capacity is equal to the mass-fraction-weighted average of heat capacities of the constituents. Thermal conductivity lies between those of the constituents up to 1200 K. Elastic constants lie between those of the constituents. The Hasselman mild thermal shock resistance parameter for the composite is twice as great as that of common 3–5 lm window materials, but half as great as that of c-plane sapphire.

Malevolent creativity (MC), or intending to inflict harm in original ways, is an aspect of creativity that has received little empirical attention. It reasons that generating malevolently creative products in response to a problem is dependent upon individual differences and environmental factors, especially with regard to the social and emotional content of a particular problem. A personality variable strongly associated with how individuals acknowledge and respond to such social and emotional content is emotional intelligence (EI). Individuals with higher EI often solve problems in cooperative, beneficial, and positive ways, which seems contrary to solving a problem with MC. In addition to testing whether EI is negatively related to MC in general, we analyzed whether that negative relationship would persist even after controlling for cognitive ability and task effects. Those questions were examined across two studies. Results suggest that individuals with lower EI are more likely to respond to different types of problems with increased instances of MC even when the social or emotional content of those problems are factored out. The implications and limitations of these studies, as well as future directions for the study of MC, are discussed.

The spectral linewidth of an ensemble of fluorescent emitters is dictated by a combination of the single emitter linewidths and sample inhomogeneities. For semiconductor nanocrystals, efforts to tune ensemble linewidths for optical applications have focused primarily on eliminating sample inhomogeneities because conventional single-molecule methods cannot reliably build accurate ensemble-level statistics for single-particle linewidths. Photon-correlation Fourier spectroscopy in solution (S-PCFS) offers a unique approach to investigating single-nanocrystal spectra with large sample statistics, without user selection bias, with high signal-to-noise ratios, and at fast timescales. With S-PCFS, we directly and quantitatively deconstruct the ensemble linewidth into contributions from the average single-particle linewidth and from sample inhomogeneity. We demonstrate that single-particle linewidths vary significantly from batch to batch and can be synthetically controlled. These findings crystallize our understanding of the synthetic challenges facing underdeveloped nanomaterials such as InP and InAs core/shell particles and introduce new avenues for the synthetic optimization of fluorescent nanoparticles.

Carbonate mud from reefs and carbonate platforms in six locations of the Atlantic, Indian, and Pacific Oceans (Belize, Bahamas, Florida, the Maldives, French Polynesia, Great Barrier Reef) was systematically and quantitatively analyzed with regard to texture, composition, mineralogy, and geochemistry. Mud composition shows considerable variability, however, the data supports the contention that these muds are largely derived from the breakdown of skeletal grains and codiacean algae. Only mud from the Bahamas and northern Belize, areas which are characterized by common whitings, is interpreted to be mainly inorganically precipitated. Three grain-size fractions (63–20 μm, 20–4 μm

Harris, D.L. and Vila-Concejo, A., 2013. Wave transformation on a coral reef rubble platform Wave transformation across coral reef platforms is the primary process affecting changes in coral reef geomorphology. Transformation regulates the amount of wave energy entering reef systems, however there have been relatively few hydrodynamic assessments conducted on coral reefs when compared to siliciclastic environments with the effects of common geomorphic features like rubble platforms on wave transformation never specifically examined. This study focuses on the changes in wave characteristics across a rubble platform in a high energy environment (One Tree Reef, southern Great Barrier Reef). Wave conditions were measured at five locations over two days along a cross-reef transect from the reef rim to lagoon. Most of the wave energy was dissipated during wave breaking with energy attenuation due to bottom friction a secondary process. Wave energy attenuation was between 60–99% of the offshore wave con...