Author: "D Fernandez" - Searchworks@Jio Institute Digital Library Search Results

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201. [Measles is back. Report of 3 cases seen in the Emergency Department]

Author: D, Fernandez-Nieto, J, Jimenez-Cauhe, B, Diaz-Guimaraens, N, Diaz-Garcia, and D, Ortega-Quijano
Subjects: Adult, Male, Young Adult, Spain, Measles Vaccine, Humans, Female, Emergency Service, Hospital, Measles
Published: 2019

202. Design for Harvesting and Treatment of Rainwater in Naval, Biliran

Author: Ramon L. Pitao, Ric Cyrell Rosialda, and Dahlia D. Fernandez
Subjects: less chemical method, customized, Mechanical Engineering, Environmental engineering, Environmental science, rainwater harvesting, Rainwater harvesting
Abstract: The study takes advantage of rainwater, a naturally processed water. Developing a design for an affordable, less chemically oriented method that would help many people gain access to the water they need easily. The design used materials that were cheap and can be easily accessed on the local market. The process starts from a stage where large particles of contaminants were removed through straining. The next was iltering the water through a sequence of sponge, charcoal, coarse and fine sand. And lastly was chlorination, which treated the rainwater from the bacteria's which were previously not removed from the filter. The study came up with the design that were easily availed on the local markets of Naval, Biliran. The components were easy to install and were effective in harvesting rainwater. The treatment results were not what the researchers envisioned it to be, but still they were able to produce safe drinking water. Sure enough, it could be an alternative for other uses aside from drinking. The design was incomplete, especially on the part of the treatment device thus, further studies are recommended for its improvement. Nevertheless, the study proved that simple customized rainwater harvester and treatment device is achievable with the materials that can easily be found on the local market. Ramon L. Pitao, Jr. | Dahlia D. Fernandez | Ric Cyrell Rosialda "Design for Harvesting and Treatment of Rainwater in Naval, Biliran" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23897.pdf
Published: 2019

203. The Infant Toddler Activity Card Sort: A Caregiver Report Measure of Children’s Occupational Engagement in Family Activities and Routines

Author: Kelly E. O’Connor, Catherine R. Hoyt, Taniya Varughese, Emma Grandgeorge, Allison A. King, Regina A. Abel, Hannah E. Manis, and Jianna D. Fernandez
Subjects: Adult, Male, 030506 rehabilitation, Delphi Technique, Delphi method, Child Behavior, Activity Card Sort, Meaningful life, Article, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Occupational Therapy, 030225 pediatrics, Intervention (counseling), Activities of Daily Living, Early Intervention, Educational, Humans, Family, Everyday life, Qualitative Research, Measure (data warehouse), Infant, Caregivers, Content analysis, Child, Preschool, Cohort, Behavior Rating Scale, Female, Family Relations, 0305 other medical science, Psychology, Behavior Observation Techniques
Abstract: Early intervention (EI) therapy services aim to address family-centered goals to facilitate young children’s development and participation in meaningful life activities. Current methods to evaluate children in EI assess discrete developmental skills but provide little information on the child’s ability to successfully incorporate that skill in everyday life. Furthermore, traditional measures have limited opportunity for parent report, despite parent engagement being a critical component for successful implementation of EI services. A measure that involves parents in the therapeutic process to track family-driven EI goals related to a child’s occupational engagement in meaningful family activities and routines is desperately needed. Using a qualitative design and conventional content analysis, we identified 41 distinct activities of infant–toddlers from a cohort of 23 caregivers. Activity items were matched with photographs and validated with experts in pediatric rehabilitation using the Delphi method. The resulting 40 activity/photograph pairs were used to develop a new measure of pediatric occupational engagement, the Infant Toddler Activity Card Sort (ITACS).
Published: 2019

204. Implementation of a non-linear CMOS and CCD focal plane array model in ASSET

Author: Fernando D. Fernandez, Kevin C. Gross, Michael R. Hawks, and Bryan J. Steward
Subjects: Noise, Emulation, Data processing, CMOS, Computer science, Detector, Electronic engineering, Node (circuits), Electronics, Synthetic data
Abstract: Electro-optical and infrared (EO/IR) sensor and scene generation models are useful tools that can facilitate understanding the behavior of an imaging system and its data processing chain under myriad scenarios without expensive and time-consuming testing of an actual system. EO/IR models are especially important to researchers in remote sensing where truth data is required but often costly and impractical to obtain. The Air Force Institute of Technology (AFIT) Sensor and Scene Emulation Tool (ASSET) is an educational, engineering-level tool developed to rapidly generate large numbers of physically realistic EO/IR data sets. This work describes the implementation of a focal plane array (FPA) model of charge-coupled device (CCD) and complementary metal-oxide semiconductor (CMOS) photodetectors as a component in ASSET. The FPA model covers conversion of photo-generated electrons to voltage and then to digital numbers. It incorporates sense node, source follower, and analog-to-digital converter (ADC) components contributing to gain non-linearities and includes noise sources associated with the detector and electronics such as shot, thermal, 1/f, and quantization noise. This paper describes the higher fidelity FPA and electronics model recently incorporated into ASSET, and it also details model validation using an EO/IR imager in laboratory measurements. The result is an improved model capable of rapidly generating realistic synthetic data representative of a wide range of EO/IR systems for use algorithm development and assessment, particularly when large numbers of truth data sets are required (e.g., machine learning).
Published: 2019

205. G479(P) Use of the rehabilitation complexity scale to assess dependency and rehabilitation complex in patients receiving in-patient neurorehabilitation at a region neuroscience centre (rnsc)

Author: D Fernandez, C Reyes Peyeras, B Hameed, T Smallbone, M Eve, PM Sharples, and I Wright
Subjects: Change over time, medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, Head injury, macromolecular substances, medicine.disease, Modified Rankin Scale, Scale (social sciences), medicine, Physical therapy, In patient, business, Student's t-test, Neurorehabilitation
Abstract: Aim To investigate feasibility of using the Rehabilitation Complexity Scale (RCS) to assess rehabilitation needs in children receiving in-patient neurorehabilitation in a RNSC. Background The RCS is established in adult neurorehabilitation practice for assessing complexity of care and therapy needs in hospital and community settings. Few data exist concerning its use in paediatric neurorehabilitation. Methods Children receiving specialist in-patient neurorehabilitation were scored on the RCS-Extended (RCS-E) by the multi-disciplinary team at weekly neurorehabilitation clinical meetings over 15 months. Patients’ functional status was scored simultaneously by King’s Outcome Score for Childhood Head Injury (KOSCHI) and Modified Rankin Scale (MRS). Demographic details were obtained from the clinical neurorehabilitation database. Statistical analyses were performed using IBM SPSS Statistics Version 21. Results 180 RCS-E, KOSCHI and MRS assessments were obtained in 34 patients, mean age=7.6 years (range 0.1–17). 43% were male, 57% female. 78% had ABI. There were significant differences between RCS-E, scored on neurorehabilitation admission and hospital discharge, for total RCS-E (admission: mean=12.97, SD=2.48; discharge: mean=9.50, SD=3.70; paired t test, p 0.05). Admission total RCS-E did not predict neurorehabilitation duration (r=0.26, p=0.10), but there was a relationship between rehabilitation duration and discharge total RCS-E (r=0.40. p=0.005). In ABI patients, correlations were seen between admission and discharge total RCS-Es and contemporaneous KOSCHI (admission, r=−0.60, p Conclusion The RCS-E is easy to use in in-patient paediatric rehabilitation practice, despite issues around the applicability of definitions of care need. The measure is sensitive to change over time and correlates with functional status. Evidence that>50% total weeks of in-patient neurorehabilitation were classed as medium-level dependency supports provision of an outreach neurorehabilitation service.
Published: 2019

206. In Situ Detection of Leakages in Partition Elements through SONAH and Beamforming Techniques

Author: Samuel Quintana, Marcos D. Fernandez, and Jose A. Ballesteros
Subjects: In situ, Beamforming, Computer science, Partition (database), Algorithm
Published: 2019

207. In Situ Detection of Leakages in Partition Elements through SONAH and Beamforming Techniques

Author: A., Ballesteros, José, Samuel, Quintana, and D., Fernandez, Marcos
Subjects: InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Published: 2019

208. 4CPS-118 Experience of dual targeting use of neoadjuvant HER2-positive breast cancer

Author: E Mateos Egido, D Fernandez Vera, A Alamo Medina, M Lombardero Pin, and ME Luján López
Subjects: Oncology, medicine.medical_specialty, Chemotherapy, Taxane, Nausea, business.industry, medicine.medical_treatment, Radiation therapy, Trastuzumab, Internal medicine, medicine, Pertuzumab, Hormone therapy, medicine.symptom, Adverse effect, business, medicine.drug
Abstract: Background Neoadjuvant chemotherapy is the treatment of choice in locally advanced breast carcinoma. Pertuzumab is approved in combination with trastuzumab and chemotherapy for the neoadjuvant treatment of patients with HER2 positive breast cancer. Purpose To evaluate the complete pathological response rate (pRC) obtained after therapy in combination with pertuzumab in our hospital. Material and methods Retrospective descriptive study of patients with confirmed diagnosis of HER2 positive breast cancer in treatment with pertuzumab in combination with trastuzumab and taxanes as neoadjuvant treatment (March 2017 to September 2018). Efficacy endpoint was the complete pathological response (pCR) that was related to efficacy and with a longer long-term survival. Adverse effects (AE) were collected for safety profile assessment. Results Twenty-eight patients were analysed. The median age was 50 years (31–74). All patients had an initial ECOG 0–1. Sixty-three per cent had positive hormone receptors. The mean LVEF of patients at the beginning of the treatment with pertuzumab was 61%. Of the total, n=25 received chemotherapy treatment with AC at dense doses for four cycles prior to the taxane sequence, two patients received TCH and one patient received FEC. Dose reduction was performed in 18% of patients. Paclitaxel weekly for 12 cycles was the taxane level administered in combination with pertuzumab and trastuzumab in 93% of the cases. Radiotherapy and hormone therapy were used when necessary. In general terms, pertuzumab in combination with trastuzumab and taxanes was well tolerated, with AE grade 1–2 such as neurotoxicity, nausea and diarrhoea. No adverse events in grade 3–4 were recorded. Currently, 17 patients have been operated on: in 13 cases with pRC, in three patients there was a Miller and Payner grade 4 response and in one patient grade 3. The rest of the patients will have surgery soon. Conclusion The data obtained so far are quite encouraging because of the good pRC rate obtained. However, we must treat them with caution due to the low number of patients who have received treatment up to now. But this treatment is going to improve the prognosis of the disease with a tolerable toxicity profile. Reference and/or acknowledgements Lancet Oncol 2016;17:791–800. No conflict of interest.
Published: 2019

209. 5PSQ-049 Atezolizumab: efficacy and safety in advanced non-small cell lung cancer

Author: D Dorta, AM Alamo, D Fernandez, M Lombardero, ME Lujan, C Otero, A Dominguez, and E Mateos
Subjects: medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Retrospective cohort study, medicine.disease, Rash, Atezolizumab, Internal medicine, medicine, In patient, Non small cell, medicine.symptom, business, Lung cancer, Adverse effect
Abstract: Background Results of the OAK study demonstrated that atezolizumab improved median overall survival and progression-free survival of patients with advanced non-small cell lung cancer (NSCLC). Purpose Evaluate the efficacy and safety of atezolizumab treatment in patients with metastasic or advanced NSCLC in second and successive lines. Material and methods Retrospective observational study in which patients with NSCLC were included who started treatment with atezolizumab in the second or successive line, during the period from April to September 2018. Data were collected on demographic variables (age and sex) and clinical variables (ECOG, smoking habit, previous chemotherapy, dose, number of cycles and adverse reactions) through clinical history (Selene) and the oncological prescription program (Farmatools). The descriptive statistical analysis was carried out through the SPSS vs22.0 program. Efficacy was evaluated in terms of progression-free survival (PFS) and overall survival (OS), calculated by the Kaplan–Meier method. To assess safety, the severity of adverse events (AA) was measured according to CTCAEv4.0 Results We analysed 14 patients, 9 males and 5 females. Ninety-three per cent were smokers or ex-smokers, and 7% had never smoked. Eleven patients had ECOG 0–1 and three ECOG 2% and 93% had metastases at the start of treatment with atezolizumab. All patients had received prior platinum-based chemotherapy as first-line treatment. The dose administered was 1200 mg every 3 weeks and the average of cycles was four. The median of PFS was 4.8 months (95% CI: 1.0 to 8.6) and the average of OS 4.5 months (95% CI: 3.6 to 5.4). 57.14% of the patients presented some AA of any degree and only 12.5% were grade 3–4. The most frequent were renal failure (37.5%), diarrhoea (25%), rash (25%), hypersensitivity (12.5%), thrombocytopaenia (12.5%), lung infection (12.5%), oedema (12.5%), emesis (12.5%) and decreased appetite (12.5%) Conclusion The efficacy in terms of OS obtained was lower than that of the OAK study (13.8 months). However, when the PFS was analysed in our study, it was superior to that of the OAK study (PFS 2.8 months). In general, atezolizumab presents an acceptable safety profile, the most frequent AEs coincide with those described in the literature. References and/or acknowledgements No conflict of interest.
Published: 2019

210. Observation of Two Excited B-c(+) States and Measurement of the B-c(+) (2S) Mass in pp Collisions at root s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I Liko, D. Madlener, T. and Mikulec, I Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wittmann, J. Wulz, C-E and Zarucki, M. Drugakov, V Mossolov, V Suarez Gonzalez, J. and Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Lelek, A. Pieters, M. Van Haevermaet, H. and Van Mechelen, P. Van Remortel, N. Blekman, F. Bols, E. S. and Chhibra, S. S. D'Hondt, J. De Clercq, J. Flouris, G. and Lontkovskyi, D. Lowette, S. Marchesini, I Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Favart, L. Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. and Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. and Wang, Q. Cornelis, T. Dobur, D. Fagot, A. Gul, M. and Khvastunov, I Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Krintiras, G. Lemaitre, V Magitteri, A. and Piotrzkowski, K. Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. Zobec, J. Alves, F. L. Alves, G. A. and Correia Silva, G. Hensel, C. Moraes, A. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Huertas Guativa, L. M. and Malbouisson, H. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. and Sanchez Rosas, L. J. Santoro, A. Sznajder, A. Thiel, M. and Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Calligaris, L. De Souza Lemos, D. Fernandez Perez Tomei, T. R. Gregores, E. M. and Mercadante, P. G. Novaes, S. F. Padula, Sandra S. and Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. Marinov, A. and Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. and Gao, X. Yuan, L. Ahmad, M. Chen, G. M. Chen, H. S. and Chen, M. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Shaheen, S. M. Spiezia, A. Tao, J. Yazgan, E. Zhang, H. Zhang, S. Zhao, J. Ban, Y. Chen, G. Li, J. and Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. Wang, Y. and Avila, C. Cabrera, A. Chaparro Sierra, L. F. Florez, C. and Gonzalez-Hernandez, C. F. Segura Delgado, M. A. Mejia Guisao, J. Ruiz Alvarez, J. D. Giljanovic, D. Godinovic, N. and Lelas, D. Puljak, I Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V Ferencek, D. Kadija, K. Mesic, B. and Roguljic, M. Starodumov, A. Susa, T. Ather, M. W. and Attikis, A. Erodotou, E. Ioannou, A. Kolosova, M. and Konstantinou, S. Mavromanolakis, G. Mousa, J. Nicolaou, C. and Ptochos, F. Razis, P. A. Rykaczewski, H. Tsiakkouri, D. and Finger, M. Finger, Jr., M. Ayala, E. Carrera Jarrin, E. and Assran, Y. Elgammal, S. Bhowmik, S. Carvalho Antunes De Oliveira, A. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Raidal, M. Veelken, C. Eerola, P. Kirschenmann, H. and Pekkanen, J. Voutilainen, M. Havukainen, J. Heikkila, J. K. and Jarvinen, T. Karimaki, V Kinnunen, R. Lampen, T. and Lassila-Perini, K. Laurila, S. Lehti, S. Linden, T. and Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. and Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. and Dejardin, M. Denegri, D. Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. De Monchenault, G. Hamel Jarry, P. Leloup, C. Locci, E. Malcles, J. and Rander, J. Rosowsky, A. Sahin, M. O. Savoy-Navarro, A. and Titov, M. Amendola, C. Beaudette, F. Busson, P. Charlot, C. Diab, B. De Cassagnac, R. Granier Kucher, I Lobanov, A. Perez, C. Martin Nguyen, M. Ochando, C. Paganini, P. and Rembser, J. Salerno, R. Sauvan, J. B. Sirois, Y. and Zabi, A. Zghiche, A. Agram, J-L Andrea, J. Bloch, D. and Bourgatte, G. Brom, J-M Chabert, E. C. Collard, C. and Conte, E. Fontaine, J-C Gele, D. Goerlach, U. Jansova, M. Le Bihan, A-C Tonon, N. Van Hove, P. Gadrat, S. and Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Chanon, N. Chierici, R. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Lagarde, F. Laktineh, I. B. Lattaud, H. Lethuillier, M. Mirabito, L. Perries, S. Sordini, V Touquet, G. Vander Donckt, M. and Viret, S. Toriashvili, T. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. and Meuser, D. Pauls, A. Preuten, M. Rauch, M. P. and Schomakers, C. Teroerde, M. Wittmer, B. Albert, A. and Erdmann, M. Erdweg, S. Esch, T. Fischer, B. Fischer, R. and Ghosh, S. Hebbeker, T. Hoepfner, K. Keller, H. and Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Millet, P. and Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. Novak, A. and Pook, T. Pozdnyakov, A. Quast, T. Radziej, M. Rath, Y. Reithler, H. Rieger, M. Schmidt, A. Schuler, S. C. and Sharma, A. Thuer, S. Wiedenbeck, S. Fluegge, G. and Hlushchenko, O. Kress, T. Mueller, T. Nehrkorn, A. and Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. and Stahl, A. Martin, M. Aldaya Asawatangtrakuldee, C. Asmuss, P. Babounikau, I Bakhshiansohi, H. Beernaert, K. Behnke, O. Behrens, U. Martinez, A. Bermudez Bertsche, D. Bin Anuar, A. A. Borras, K. Botta, V Campbell, A. Cardini, A. Connor, P. Rodriguez, S. Consuegra Contreras-Campana, C. and Danilov, V De Wit, A. Defranchis, M. M. Pardos, C. Diez and Damiani, D. Dominguez Eckerlin, G. Eckstein, D. and Eichhorn, T. Elwood, A. Eren, E. Gallo, E. Geiser, A. and Luyando, J. M. Grados Grohsjean, A. Guthoff, M. Haranko, M. Harb, A. Jomhari, N. Z. Jung, H. Kasem, A. and Kasemann, M. Keaveney, J. Kleinwort, C. Knolle, J. and Kruecker, D. Lenz, T. Leonard, J. Lidrych, J. Lipka, K. and Lohmann, W. Mankel, R. Melzer-Pellmann, I-A Meyer, A. B. and Meyer, M. Missiroli, M. Mittag, G. Mnich, J. and Mussgiller, A. Myronenko, V Adan, D. Perez Pflitsch, S. K. and Pitzl, D. Raspereza, A. Saibel, A. Savitskyi, M. and Scheurer, V Schuetze, P. Schwanenberger, C. Shevchenko, R. and Singh, A. Tholen, H. Turkot, O. Vagnerini, A. Van De Klundert, M. Van Onsem, G. P. Walsh, R. Wen, Y. and Wichmann, K. Wissing, C. Zenaiev, O. Zlebcik, R. and Aggleton, R. Bein, S. Benato, L. Benecke, A. Blobel, V and Dreyer, T. Ebrahimi, A. Froehlich, A. Garbers, C. and Garutti, E. Gonzalez, D. Gunnellini, P. Haller, J. and Hinzmann, A. Karavdina, A. Kasieczka, G. Klanner, R. and Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V Lange, J. and Lange, T. Malara, A. Marconi, D. Multhaup, J. and Niedziela, M. Niemeyer, C. E. N. Nowatschin, D. Perieanu, A. and Reimers, A. Rieger, O. Scharf, C. Schleper, P. and Schumann, S. Schwandt, J. Sonneveld, J. Stadie, H. and Steinbrueck, G. Stober, F. M. Stoever, M. Vormwald, B. and Zoi, I Akbiyik, M. Barth, C. Baselga, M. Baur, S. and Berger, T. Butz, E. Chwalek, T. De Boer, W. Dierlamm, A. and El Morabit, K. Giffels, M. Goldenzweig, P. Harrendorf, M. A. Hartmann, F. Husemann, U. Kudella, S. Mitra, S. and Mozer, M. U. Mueller, Th Musich, M. Nuernberg, A. and Quast, G. Rabbertz, K. Schroeder, M. Shvetsov, I and Simonis, H. J. Ulrich, R. Weber, M. Woehrmann, C. Wolf, R. Anagnostou, G. Asenov, P. Daskalakis, G. Geralis, T. and Kyriakis, A. Loukas, D. Paspalaki, G. Diamantopoulou, M. and Karathanasis, G. Kontaxakis, P. Panagiotou, A. and Papavergou, I Saoulidou, N. Theofilatos, K. Vellidis, K. and Bakas, G. Kousouris, K. Papakrivopoulos, I Tsipolitis, G. and Evangelou, I Foudas, C. Gianneios, P. Katsoulis, P. and Kokkas, P. Mallios, S. Manitara, K. Manthos, N. and Papadopoulos, I Paradas, E. Strologas, J. Triantis, F. A. and Tsitsonis, D. Bartok, M. Csanad, M. Major, P. and Mandal, K. Mehta, A. Nagy, I, M. Pasztor, G. Suranyi, O. and Veres, I, G. Bencze, G. Hajdu, C. Horvath, D. and Sikler, F. Hunyadi, A. Vami, T. A. Veszpremi, V. and Vesztergombi, G. Beni, N. Czellar, S. Karancsi, J. and Makovec, A. Molnar, J. Szillasi, Z. Raics, P. Teyssier, D. Trocsanyi, Z. L. Ujvari, B. Choudhury, S. Komaragiri, J. R. Tiwari, P. C. Bahinipati, S. Kar, C. Mal, P. and Bindhu, V. K. Muraleedharan Nair Nayak, A. Chowdhury, S. Roy and Sahoo, D. K. Swain, S. K. Bansal, S. Bhatnagar, V and Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. and Kaur, M. Kaur, S. Kumari, P. Lohan, M. Meena, M. and Sandeep, K. Sharma, S. Singh, J. B. Virdi, A. K. Walia, G. Bhardwaj, A. Choudhary, B. C. Garg, R. B. Gola, M. and Keshri, S. Kumar, Ashok Malhotra, S. Naimuddin, M. and Priyanka, P. Ranjan, K. Shah, Aashaq Sharma, R. and Bhardwaj, R. Bharti, M. Bhattacharya, R. Bhattacharya, S. and Bhawandeep, U. Bhowmik, D. Dey, S. Dutta, S. Ghosh, S. Maity, M. Mondal, K. Nandan, S. Purohit, A. Rout, P. K. Roy, A. Saha, G. Sarkar, S. Sarkar, T. Sharan, M. Singh, B. Thakur, S. Behera, P. K. Muhammad, A. and Chudasama, R. Dutta, D. Jha, V Kumar, V Mishra, D. K. and Netrakanti, P. K. Pant, L. M. Shukla, P. Aziz, T. and Bhat, M. A. Dugad, S. Mohanty, G. B. Sur, N. Verma, Ravindra Kumar Banerjee, S. Bhattacharya, S. Chatterjee, S. and Das, P. Guchait, M. Karmakar, S. Kumar, S. Majumder, G. Mazumdar, K. Sawant, S. Chauhan, S. Dube, S. and Hegde, V Kapoor, A. Kothekar, K. Pandey, S. Rane, A. and Rastogi, A. Sharma, S. Chenarani, S. Tadavani, E. Eskandari and Etesami, S. M. Khakzad, M. Najafabadi, M. Mohammadi and Naseri, M. Hosseinabadi, F. Rezaei Safarzadeh, B. Felcini, M. Grunewald, M. Abbrescia, M. Calabria, C. Colaleo, A. and Creanza, D. Cristella, L. De Filippis, N. De Palma, M. and Di Florio, A. Fiore, L. Gelmi, A. Iaselli, G. Ince, M. Lezki, S. Maggi, G. Maggi, M. Miniello, G. My, S. and Nuzzo, S. Pompili, A. Pugliese, G. Ranieri, A. and Selvaggi, G. Silvestris, L. Venditti, R. Verwilligen, P. and Abbiendi, G. Battilana, C. Bonacorsi, D. 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Janjam, R. Johns, W. and Maguire, C. Ni, H. Romeo, F. Sheldon, P. Tuo, S. and Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. Joyce, M. Ledovskoy, A. and Neu, C. Tannenwald, B. Wang, Y. Wolfe, E. Xia, F. and Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. and Zaleski, S. Buchanan, J. Caillol, C. Carlsmith, D. and Dasu, S. De Bruyn, I Dodd, L. Gomber, B. Grothe, M. and Herndon, M. Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Long, K. Loveless, R. Ruggles, T. Savin, A. and Sharma, V Smith, W. H. Woods, N. CMS Collaboration
Subjects: High Energy Physics::Experiment, Nuclear Experiment
Abstract: Signals consistent with the B-c(+)(2S) and B-c*(+)(2S) states are observed in proton-proton collisions at root s = 13 TeV, in an event sample corresponding to an integrated luminosity of 143 fb(-1), collected by the CMS experiment during the 2015-2018 LHC running periods. These excited (b) over barc states are observed in the B-c(+)pi(+)pi(-) invariant mass spectrum, with the ground state B-c(+) reconstructed through its decay to J/psi pi(+). The two states are reconstructed as two well-resolved peaks, separated in mass by 29.1 +/- 1.5(stat) +/- 0.7(syst) MeV. The observation of two peaks, rather than one, is established with a significance exceeding five standard deviations. The mass of the B-c(+)(2S) meson is measured to be 6871.0 +/- 1.2(stat) +/- 0.8(syst) +/- 0.8(B-c(+)) MeV, where the last term corresponds to the uncertainty in the world-average B-c(+) mass.
Published: 2019

211. ITACS.App.B.TABLE.1.29.19 – Supplemental material for The Infant Toddler Activity Card Sort: A Caregiver Report Measure of Children’s Occupational Engagement in Family Activities and Routines

Author: Hoyt, Catherine R., Jianna D. Fernandez, Taniya E. Varughese, Grandgeorge, Emma, Manis, Hannah E., O’Connor, Kelly E., Abel, Regina A., and King, Allison A.
Subjects: 111708 Health and Community Services, FOS: Health sciences
Abstract: Supplemental material, ITACS.App.B.TABLE.1.29.19 for The Infant Toddler Activity Card Sort: A Caregiver Report Measure of Children’s Occupational Engagement in Family Activities and Routines by Catherine R. Hoyt, Jianna D. Fernandez, Taniya E. Varughese, Emma Grandgeorge, Hannah E. Manis, Kelly E. O’Connor, Regina A. Abel and Allison A. King in OTJR: Occupation, Participation and Health
Published: 2019
Full Text: View/download PDF

212. Search for a Light Charged Higgs Boson Decaying to a W Boson and a CP-Odd Higgs Boson in Final States with e mu mu or mu mu mu in Proton-Proton Collisions at root s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I Liko, D. Madlener, T. and Mikulec, I Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wittmann, J. Wulz, C-E and Zarucki, M. Drugakov, V Mossolov, V Gonzalez, J. Suarez and Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Lelek, A. Pieters, M. Van Haevermaet, H. and Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. and Bols, E. S. Chhibra, S. S. D'Hondt, J. De Clercq, J. and Flouris, G. Lontkovskyi, D. Lowette, S. Marchesini, I and Moortgat, S. Moreels, L. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I and Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. and Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. and Vannerom, D. Wang, Q. Cornelis, T. Dobur, D. and Khvastunov, I Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Krintiras, G. Lemaitre, V Magitteri, A. and Piotrzkowski, K. Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. Zobec, J. Alves, F. L. Alves, G. A. and Correia Silva, G. Hensel, C. Moraes, A. Teles, P. Rebello Belchior Batista Das Chagas, E. Carvalho, W. and Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. and Damiao, D. De Jesus De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. Martins, J. and Matos Figueiredo, D. Medina Jaime, M. De Almeida, M. Melo and Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. Sznajder, A. and Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. and Vilela Pereira, A. Ahuja, S. 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E. and Hangal, D. A. Hofman, D. J. Jung, K. Mills, C. Roy, T. and Tonjes, M. B. Varelas, N. Wang, H. Wang, X. Wu, Z. and Zhang, J. Alhusseini, M. Bilki, B. Clarida, W. and Dilsiz, K. Durgut, S. Gandrajula, R. P. Haytmyradov, M. and Khristenko, V Kseyan, O. K. Merlo, J-P Mestvirishvili, A. and Moeller, A. Nachtman, J. Ogul, H. Onel, Y. Ozok, F. and Penzo, A. Snyder, C. Tiras, E. Wetzel, J. and Blumenfeld, B. Cocoros, A. Eminizer, N. Fehling, D. and Feng, L. Gritsan, V, A. Hung, W. T. Maksimovic, P. and Roskes, J. Swartz, M. Xiao, M. Barrera, C. Baldenegro and Baringer, P. Bean, A. Boren, S. Bowen, J. Bylinkin, A. and Isidori, T. Khalil, S. King, J. Kropivnitskaya, A. and Majumder, D. Mcbrayer, W. Minafra, N. Murray, M. Rogan, C. Royon, C. Sanders, S. Schmitz, E. Takaki, J. D. Tapia and Williams, J. Duric, S. Ivanov, A. Kaadze, K. Kim, D. and Maravin, Y. Mendis, D. R. Mitchell, T. Modak, A. and Mohammadi, A. Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S. C. Feng, Y. Ferraioli, C. and Hadley, N. J. Jabeen, S. Jeng, G. Y. Kellogg, R. G. and Kunkle, J. Mignerey, A. C. Nabili, S. Ricci-Tam, F. and Seidel, M. Shin, Y. H. Skuja, A. Tonwar, S. C. Wong, K. and Abercrombie, D. Allen, B. Baty, A. Bi, R. Brandt, S. and Busza, W. Cali, I. A. DAlfonso, M. Ceballos, G. Gomez and Goncharov, M. Harris, P. Hsu, D. Hu, M. Klute, M. and Kovalskyi, D. Lee, Y-J Luckey, P. D. Maier, B. and Marini, A. C. Mcginn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. and Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. and Wang, T. W. Wyslouch, B. Benvenuti, A. C. Chatterjee, R. M. Evans, A. Guts, S. Hansen, P. Hiltbrand, J. and Kalafut, S. Kubota, Y. Lesko, Z. Mans, J. Rusack, R. and Wadud, M. A. Acosta, J. G. Oliveros, S. Avdeeva, E. and Bloom, K. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. and Suarez, R. Gonzalez Kamalieddin, R. Kravchenko, I Siado, J. E. Snow, G. R. Stieger, B. Godshalk, A. Harrington, C. Iashvili, I. Kharchilava, A. Mclean, C. Nguyen, D. and Parker, A. Rappoccio, S. Roozbahani, B. Alverson, G. and Barberis, E. Freer, C. Haddad, Y. Hortiangtham, A. and Madigan, G. Morse, D. M. Orimoto, T. Skinnari, L. and Tishelman-Charny, A. Wamorkar, T. Wang, B. Wisecarver, A. and Wood, D. Bueghly, J. Gunter, T. Hahn, K. A. Odell, N. Schmitt, M. H. Sung, K. Trovato, M. Velasco, M. and Bucci, R. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Hurtado Jessop, C. Karmgard, D. J. Lannon, K. Li, W. and Loukas, N. Marinelli, N. Mcalister, I Meng, F. Mueller, C. Musienko, Y. Planer, M. Ruchti, R. Siddireddy, P. and Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. and Woodard, A. Alimena, J. Bylsma, B. Durkin, L. S. and Flowers, S. Francis, B. Hill, C. Ji, W. Lefeld, A. and Ling, T. Y. Winer, B. L. Cooperstein, S. Dezoort, G. and Elmer, P. Hardenbrook, J. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kwan, S. Lange, D. Lucchini, M. T. and Luo, J. Marlow, D. Mei, K. Ojalvo, I Olsen, J. and Palmer, C. Piroue, P. Salfeld-Nebgen, J. Stickland, D. and Tully, C. Norberg, S. Barker, A. Barnes, V. E. Das, S. and Gutay, L. Jones, M. Jung, A. W. Khatiwada, A. and Mahakud, B. Miller, D. H. Negro, G. Neumeister, N. Peng, C. C. Piperov, S. Qiu, H. Schulte, J. F. Sun, J. and Wang, F. Xiao, R. Xie, W. Cheng, T. Dolen, J. and Parashar, N. Ecklund, K. M. Freed, S. Geurts, F. J. M. and Kilpatrick, M. Kumar, Arun Padley, B. P. Redjimi, R. and Roberts, J. Rorie, J. Shi, W. Leiton, A. G. Stahl Tu, Z. and Zhang, A. Bodek, A. de Barbaro, P. Demina, R. Duh, Y. T. Dulemba, J. L. Fallon, C. Ferbel, T. Galanti, M. and Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Tan, P. Taus, R. and Chiarito, B. Chou, J. P. Gandrakota, A. Gershtein, Y. and Halkiadakis, E. Hart, A. Heindl, M. Hughes, E. Kaplan, S. Kyriacou, S. Laflotte, I Lath, A. Montalvo, R. and Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. and Sheffield, D. Somalwar, S. Stone, R. Thomas, S. and Thomassen, P. Acharya, H. Delannoy, A. G. Heideman, J. and Riley, G. Spanier, S. Bouhali, O. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Luo, S. Marley, D. and Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. De Guio, F. Kunori, S. and Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. and Undleeb, S. Volobouev, I Whitbeck, A. Greene, S. and Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. and Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. and Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. Joyce, M. Ledovskoy, A. and Neu, C. Tannenwald, B. Wolfe, E. Xia, F. Harr, R. and Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. and De Bruyn, I Dodd, L. Gomber, B. Grothe, M. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Long, K. Loveless, R. Ruggles, T. Savin, A. Smith, W. H. and Woods, N. CMS Collaboration
Subjects: Condensed Matter::Quantum Gases, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: A search for a light charged Higgs boson (H+) decaying to a W boson and a CP-odd Higgs boson (A) in final states with e mu mu or mu mu mu is performed using data from pp collisions at root s = 13 TeV, recorded by the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb(-1). In this search, it is assumed that the H+ boson is produced in decays of top quarks, and the A boson decays to two oppositely charged muons. The presence of signals for H+ boson masses between 100 and 160 GeV and A boson masses between 15 and 75 GeV is investigated. No evidence for the production of the H+ boson is found. Upper limits at 95% confidence level are obtained on the combined branching fraction for the decay chain, t -> bH(+) -> bW(+)A -> bW(+)mu(+)mu(-), of 1.9 x 10(-6) to 8.6 x 10(-6), depending on the masses of the H+ and A bosons. These are the first limits for these decay modes of the H+ and A bosons.
Published: 2019

213. The role of LIN28B and XRN2 on microRNA regulation in neuroblastoma

Author: Raquel D. Fernandez (7959380)
Subjects: Neuroblastoma, neoplasms, Uncategorized
Abstract: Neuroblastoma is a pediatric cancer whose heterogeneous nature is reflected in clinically favorable and unfavorable tumor subtypes, with tumors having MYCN amplification or loss of chromosome l l q being associated with particularly poor patient survival. In particular, the severity of deregulation caused by the aberrant expression of MYCN means that it remains the most important genetic prognostic marker of the disease, despite advances in the field. This thesis examines signals up and down-stream of MYCN in an attempt to further elucidate its role in neuroblastoma pathogenesis. Previously, microRNA profiling of a set of 145 primary neuroblastoma tumors identified a miRNA signature deregulated as a result of MYCN amplification and predictive of clinical outcome in neuroblastoma. Following on from this work it was decided to examine signals that could in turn regulate MYCN expression. This led to a refined analysis of the let-7 family of miRNAs, all of which were predicted to target the 3' UTR of MYCN mRNA. Results of this analysis provide the first evidence that the down-regulation of several let-7 family members are significantly associated with poor patient EFS and OS in neuroblastoma. Multivariate analysis then demonstrated that a signature comprising the entire let-7 family was predictive of patient survival independent of patient age and disease stage. Moreover, ectopic up-regulation of let-7a significantly impeded cell viability of both MYCN amplified and non-amplified neuroblastoma cell lines. It was also determined that the let 7 family (with the exception of let-7e and miR-98) exhibit coordinate expression across the tumour cohort. This is likely a consequence of LIN28B, a known inhibitor of primary and/or pre-let-7 processing, which is up-regulated in tumors from patients with poor survival. Another key element in this signaling pathway was discovered after llqLOH tumours were identified as the tumour subtype with lowest expression of the let-7 family. The expression of mir-125b, which maps to the deleted region on l l q , was positively correlated with let-7 and inversely correlated with LIN28B. Validation of LIN28B as a direct target of miR-125b explained, at least in part, LIN28B up-regulation in llqLOH tumours. It is also of note that expression of the let-7 family was lower in MYCN tumours compared to all other tumours lacking llqLOH. Results strongly indicate MYCN is not regulating LIN28B but is in fact downstream of LIN28B. Therefore, it is the blocking of the let-7 family by LIN28B that causes an up-regulation of MYCN. We conclude from this work that let-7 family members act as tumor suppressors in MYCN amplified and l lq - neuroblastoma tumor subtypes, although each of the tumor subtypes appear to differ in their endogenous levels of these miRNAs. Additionally, this thesis investigates the mechanism underlying the widespread down-regulation of miRNAs observed in MYCN amplified tumours. Previous work by Chartterjee et al., which demonstrated that XRN2 can degrade a specific subset of miRNAs in Caenorhabditis elegans, led to the examination of this exoribonuclease in neuroblastoma. The data demonstrates that XRN2 is highly expressed in high risk tumours, and significantly over-expressed in the MYCN amplified tumour subtype. Direct binding of MYCN to the promoter region of XRN2 was confirmed by ChlP-sequencing data, and positive regulation of XRN2 was demonstrated using the MYCN repressible SHEP-21N cell line. Subsequent miRNA profiling of XRN2 silenced cells demonstrated the up-regulation of a set of tumour suppressive miRNAs (miR-330, miR-143, miR-149, miR-148b, miR-140, and miR- 26a), which were down-regulated in MYCN amplified tumours. Consistent with this finding, silencing of XRN2 resulted in a significant decrease in cell proliferation in the MYCN amplified Kelly and in the non MYCN SKNAS cell lines. The data demonstrates that all-trans-retinoic acid (ATRA), a compound that causes differentiation in many neuroblastoma cell lines, reduces XRN2 protein levels. In contrast, XRN2 silencing produced a more differentiated phenotype in SHSY5Y, suggesting that XRN2 may be involved in the ATRA-induced differentiation of neuroblastoma cell lines. This thesis hypothesises that the aberrant expression of LIN28B and XRN2 has contributed to the down-regulation of tumour suppressor miRNAs in neuroblastoma, each of them acting at different levels during miRNA biogenesis: 1. Over-expression of LIN28B in high-risk tumours is responsible for the inhibition of the processing into mature miRNA of the let-7 family members. a. The expression of LIN28B is increased in llqLOH and MNA tumours. In llqLO H tumours, the loss of miR-125b contributes to increased expression of LIN28B as it directly regulates LIN28B protein expression. b. In turn, over-expression of LIN28B contributes to enhanced MYCN expression through the down-regulation of the let-7 members as this family of miRNAs directly regulates MYCN expression posttranscriptionally. c. Expression of LIN28B is a prognostic factor of survival independent of MYCN status, patient age and stage. Similarly, the down-regulation of a let-7 expression signature is predictive of poor survival in neuroblastoma tumours. 2. The 3'-5' exoribonuclease XRN2 is responsible for the degradation of a subset of mature miRNAs that might act as tumour suppressor miRNAs and be involved in differentiation: a. MYCN promotes XRN2 expression b. XRN2 knockdown results in the up-regulation of a subset of miRNAs that are significantly down-regulated in MNA tumours and are associated with poor survival. This thesis hypothesizes that XRN2 is the effector of MYCN driven down-regulation of a specific subset of miRNAs. The findings presented in this thesis demonstrate how deregulation of the LIN28-let-7-MYCN pathway contributes to the enhanced expression of MYCN and neuroblastoma progression. The elucidation of this pathway might offer new opportunities for pharmacological intervention and new therapeutic approaches for neuroblastoma. In addition, the identification of the 5'-3' exoribonuclease XRN2 as the causative agent for the decay of mature tumour suppressive miRNAs opens new perspectives in the field of miRNA stability and the mechanisms of posttranscriptional gene regulation, as well as a mechanism underlying the downregulation of some tumour suppressor miRNAs in neuroblastoma pathogenesis.
Published: 2019
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214. Global monitoring of volcanic SO2 degassing with unprecedented resolution from TROPOMI onboard Sentinel-5 Precursor

Author: Benoit Taisne, I. De Smedt, M. Van Roozendael, Santiago Arellano, Hugo Delgado-Granados, D Fernandez, Charlotte Barrington, Mattia Pedergnana, Bo Galle, Christophe Lerot, Huan Yu, Nicolas Theys, Pascal Hedelt, Jonas Vlietinck, Diego Loyola, C J M Carlito, Asian School of the Environment, and Earth Observatory of Singapore
Subjects: 0301 basic medicine, Sentinel-5 Precursor, lcsh:Medicine, SO2, TROPOMI, Article, Wind speed, Troposphere, 03 medical and health sciences, 0302 clinical medicine, Nadir, Environmental Impact, lcsh:Science, Remote sensing, Data source, Ozone Monitoring Instrument, geography, Multidisciplinary, geography.geographical_feature_category, lcsh:R, Hyperspectral imaging, Atmosphärenprozessoren, Social sciences::Geography::Environmental sciences [DRNTU], 030104 developmental biology, Volcano, Atmospheric chemistry, Atmospheric Chemistry, Environmental science, lcsh:Q, Volcanoes, 030217 neurology & neurosurgery
Abstract: Over the last four decades, space-based nadir observations of sulfur dioxide (SO2) proved to be a key data source for assessing the environmental impacts of volcanic emissions, for monitoring volcanic activity and early signs of eruptions, and ultimately mitigating related hazards on local populations and aviation. Despite its importance, a detailed picture of global SO2 daily degassing is difficult to produce, notably for lower-tropospheric plumes, due largely to the limited spatial resolution and coverage or lack of sensitivity and selectivity to SO2 of current (and previous) nadir sensors. We report here the first volcanic SO2 measurements from the hyperspectral TROPOspheric Monitoring Instrument (TROPOMI) launched in October 2017 onboard the ESA’s Sentinel-5 Precursor platform. Using the operational processing algorithm, we explore the benefit of improved spatial resolution to the monitoring of global volcanic degassing. We find that TROPOMI surpasses any space nadir sensor in its ability to detect weak degassing signals and captures day-to-day changes in SO2 emissions. The detection limit of TROPOMI to SO2 emissions is a factor of 4 better than the heritage Aura/Ozone Monitoring Instrument (OMI). Here we show that TROPOMI SO2 daily observations carry a wealth of information on volcanic activity. Provided with adequate wind speed data, temporally resolved SO2 fluxes can be obtained at hourly time steps or shorter. We anticipate that TROPOMI SO2 data will help to monitor global volcanic daily degassing and better understand volcanic processes and impacts.
Published: 2019

215. Wide-bandwidth thru-reflect-line calibration for empty substrate integrated coaxial line with grounded coplanar transitions

Author: Angel Belenguer, Jose A. Ballesteros, Marcos D. Fernandez, Juan J. de Dios, and J. A. Martínez
Subjects: Materials science, business.industry, 020208 electrical & electronic engineering, Bandwidth (signal processing), Grounded Coplanar (GCPW), 020206 networking & telecommunications, 02 engineering and technology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Thru-reflect-line, Electronic, Optical and Magnetic Materials, Optics, Calibration, 0202 electrical engineering, electronic engineering, information engineering, Coaxial line, Electrical and Electronic Engineering, business, Empty substrate-integrated coaxial line (ESICL)
Abstract: Empty coaxial structures built with printed circuit boards have low radiation, low losses, high quality factor and non-dispersive features. The fully integration of empty substrate-integrated coaxial line (ESICL) in a planar substrate is nowadays a fact thanks to a grounded coplanar transition. To properly characterize and measure this new ESICL family of devices, a low cost and easy to manufacture thru-reflect-line calibration kit is proposed to de-embed not only the connectors and feeding lines, but also the ESICL transitions.
Published: 2019

216. Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases

Author: D. Fernandez-Justel, Peter Schürmann, Mónica Balsera, José L. Revuelta, Rubén M. Buey, J.M. de Pereda, Bob B. Buchanan, Ministerio de Economía y Competitividad (España), and European Commission
Subjects: 0301 basic medicine, Models, Molecular, Stereochemistry, Protein Conformation, Thioredoxin reductase, Flavoprotein, Sequence Homology, Flavin group, Reductase, Crystallography, X-Ray, Cofactor, 03 medical and health sciences, Models, Oxidoreductase, Sequence Analysis, Protein, Thioredoxin, Ferredoxin, chemistry.chemical_classification, Crystallography, Multidisciplinary, 030102 biochemistry & molecular biology, biology, Flavoproteins, Chemistry, Protein conformational dynamics, Protein, Redox-active disulfide, Molecular, thioredoxin reductase, Biological Sciences, 030104 developmental biology, X-Ray, biology.protein, Ferredoxins, Clostridium acetobutylicum, Sequence Analysis, Oxidation-Reduction, NADP
Abstract: Ferredoxin-dependent thioredoxin reductase was identified 35 y ago in the fermentative bacterium Clostridium pasteurianum [Hammel KE, Cornwell KL, Buchanan BB (1983) Proc Natl Acad Sci USA 80:3681–3685]. The enzyme, a flavoprotein, was strictly dependent on ferredoxin as reductant and was inactive with either NADPH or NADH. This early work has not been further pursued. We have recently reinvestigated the problem and confirmed that the enzyme, here designated ferredoxin-dependent flavin thioredoxin reductase (FFTR), is a flavoprotein. The enzyme differs from ferredoxin−thioredoxin reductase (FTR), which has a signature [4Fe−4S] cluster, but shows structural similarities to NADP-dependent thioredoxin reductase (NTR). Comparative amino acid sequence analysis showed that FFTR is present in a number of clostridial species, some of which lack both FTR and an archetypal NTR. We have isolated, crystallized, and determined the structural properties of FFTR from a member of this group, Clostridium acetobutylicum, both alone and in complex with Trx. The structures showed an elongated FFTR homodimer, each monomer comprising two Rossmann domains and a noncovalently bound FAD cofactor that exposes the isoalloxazine ring to the solvent. The FFTR structures revealed an alternative domain organization compared with NTR that enables the enzyme to accommodate Fdx rather than NADPH. The results suggest that FFTR exists in a range of conformations with varying degrees of domain separation in solution and that the stacking between the two redox-active groups for the transfer of reducing equivalents results in a profound structural reorganization. A mechanism in accord with the findings is proposed., This work was supported by Spanish Ministerio de Ciencia, Innovación y Universidades Grants BFU2016-80343-P and BIO2016-75634-P. The research leading to these results received funding from the European Community’s Seventh Framework Program FP7/2007–2013 under BioStruct-X Grant Agreement 7687.
Published: 2018

217. Fog Water Collection Effectiveness: Mesh Intercomparisons

Author: D. Fernandez, Peter Weiss-Penzias, Robert E. Cohen, Bong June Zhang, Gareth H. McKinley, Alicia Torregrosa, Matthew Bowman, Deckard Sorensen, Justin A. Kleingartner, Andrew J. Oliphant, Massachusetts Institute of Technology. Department of Chemical Engineering, Cohen, Robert E, McKinley, Gareth H., and Kleingartner, Justin Alan
Subjects: 010504 meteorology & atmospheric sciences, Meteorology, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Pollution, Wind speed, Water collection, Aerosol, Rainwater harvesting, Environmental Chemistry, Environmental science, 0210 nano-technology, 0105 earth and related environmental sciences
Abstract: To explore fog water harvesting potential in California, we conducted long-term measurements involving three types of mesh using standard fog collectors (SFC). Volumetric fog water measurements from SFCs and wind data were collected and recorded in 15-minute intervals over three summertime fog seasons (2014–2016) at four California sites. SFCs were deployed with: standard 1.00 m[superscript 2] double-layer 35% shade coefficient Raschel; stainless steel mesh coated with the MIT-14 hydrophobic formulation; and FogHa-Tin, a German manufactured, 3-dimensional spacer fabric deployed in two orientations. Analysis of 3419 volumetric samples from all sites showed strong relationships between mesh efficiency and wind speed. Raschel mesh collected 160% more fog water than FogHa-Tin at wind speeds less than 1 m s[superscript –1] and 45% less for wind speeds greater than 5 m s[superscript –1]. MIT-14 coated stainless-steel mesh collected more fog water than Raschel mesh at all wind speeds. At low wind speeds of < 1 m s[superscript –1] the coated stainless steel mesh collected 3% more and at wind speeds of 4– 5 m s[superscript –1], it collected 41% more. FogHa-Tin collected 5% more fog water when the warp of the weave was oriented vertically, per manufacturer specification, than when the warp of the weave was oriented horizontally. Time series measurements of three distinct mesh across similar wind regimes revealed inconsistent lags in fog water collection and inconsistent performance. Since such differences occurred under similar wind-speed regimes, we conclude that other factors play important roles in mesh performance, including in-situ fog event and aerosol dynamics that affect droplet-size spectra and droplet-to-mesh surface interactions. Keywords: Fog mesh, Fog water collection efficiency, Raschel mesh, Hydrophobic coating, National Science Foundation (U.S.) (Grant OCE-1333976), Geological Survey (U.S.). Climate and Land Use Change Mission Area, NBD Nanotechnologies, National Science Foundation (U.S.). Small Business Innovation Research Program (Award 2015-33610-23832)
Published: 2018

218. Correlation between dermoscopy and direct microscopy in Tinea barbae

Author: A. Vera Casano, L. Martínez Pilar, D.J. Godoy Diaz, M D Fernandez Ballesteros, T. Martín González, Elisabeth Gómez-Moyano, S. Martínez García, and B Moyano Almagro
Subjects: 0303 health sciences, medicine.medical_specialty, animal structures, integumentary system, 030306 microbiology, fungi, Direct microscopy, Biology, Dermatology, Trichoscopy, 03 medical and health sciences, Infectious Diseases, medicine.anatomical_structure, embryonic structures, medicine, Moustache
Abstract: Tineabarbae is a rare form of dermatophytosis that affects hair follicles of the beard and moustache. Dermoscopy could prove useful to identify parasitism of hair of the beard, just as it has proven useful in the diagnosis of Tineacapitis. We present the first fully documented case series of T. barbae with clinical, dermoscopic and mycological features.
Published: 2021

219. The Semantic Web: ESWC 2020 Satellite Events : ESWC 2020 Satellite Events, Heraklion, Crete, Greece, May 31 – June 4, 2020, Revised Selected Papers

Author: Andreas Harth, Valentina Presutti, Raphaël Troncy, Maribel Acosta, Axel Polleres, Javier D. Fernández, Josiane Xavier Parreira, Olaf Hartig, Katja Hose, Michael Cochez, Andreas Harth, Valentina Presutti, Raphaël Troncy, Maribel Acosta, Axel Polleres, Javier D. Fernández, Josiane Xavier Parreira, Olaf Hartig, Katja Hose, and Michael Cochez
Subjects: Information storage and retrieval systems, Machine theory, Application software, Expert systems (Computer science), Database management
Abstract: Chapter “ABECTO: An ABox Evaluation and Comparison Tool for Ontologies” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Published: 2020

220. Basophil Activation Marker Selection, CD63 or CD203c, Improves Sensitivity of Basophil Activation Test Depending on the Clinical Entity in Immediate Allergic Reactions to Betalactams

Author: Gador Bogas Herrera, Maria Salas, Tahia D. Fernandez, Cristobalina Mayorga, Adriana Ariza Veguillas, Ruben Fernandez-Santamaria, Maria Torres JaÃ©n, and Ana Molina Bueno
Subjects: Basophil activation, CD63, business.industry, Immunology, Immunology and Allergy, Medicine, Sensitivity (control systems), business, Marker selection
Published: 2021

221. Osteoarticular allograft reconstruction of post-traumatic defect of distal femur in a pediatric patient: A case report and literature review

Author: Harish Kempegowda, Amrut Borade, Meagan D. Fernandez, and Daniel S. Horwitz
Subjects: musculoskeletal diseases, medicine.medical_specialty, Time Factors, Knee Joint, Radiography, Fracture Fixation, Internal, Fractures, Open, 03 medical and health sciences, 0302 clinical medicine, Vancomycin, medicine, Deformity, Humans, Therapeutic Irrigation, Physis, Degloving Injuries, Fractures, Comminuted, General Environmental Science, Valgus deformity, 030222 orthopedics, Bone Transplantation, business.industry, Cartilage, Soft tissue, 030208 emergency & critical care medicine, Allografts, Limb Salvage, medicine.disease, Anti-Bacterial Agents, Surgery, Joint Deformities, Acquired, Pediatric patient, Treatment Outcome, medicine.anatomical_structure, Debridement, Splints, Child, Preschool, Soft tissue injury, General Earth and Planetary Sciences, Female, Gentamicins, medicine.symptom, business, Leg Injuries
Abstract: Successful results of osteoarticular allografts in reconstruction of periarticular bone defect after tumor resection encouraged its utilization in post-traumatic defects. Here we describe a case of post-traumatic skeletal defect in a 4 year-old girl treated with osteoarticular allograft reconstruction. Due to severity of the associated soft tissue injury and contamination at presentation staged treatment with antibiotic spacer followed by the reconstruction was carried out. At the end of one year the patient achieved 'Musculoskeletal tumor society' functional score of 27 points and radiographic score of 93%. Reconstruction immediately after healing of soft tissues prevented development of any varus or valgus deformity of the knee. Our case demonstrates utility of osteoarticular allograft in a pediatric post-traumatic skeletal defect.
Published: 2016

222. Application of signal preprocessing and blind source separation to sound power mesurement of machines

Author: Ma Jesús Ballesteros, Jose A. Ballesteros, and Marcos D. Fernandez
Subjects: Acoustics and Ultrasonics, Computer science, Mechanical Engineering, Fast Fourier transform, Public Health, Environmental and Occupational Health, Aerospace Engineering, 02 engineering and technology, Building and Construction, Sound power, Signal, Blind signal separation, Industrial and Manufacturing Engineering, Background noise, Wavelet, Automotive Engineering, Cepstrum, 0202 electrical engineering, electronic engineering, information engineering, Discrete cosine transform, Electronic engineering, 020201 artificial intelligence & image processing, Algorithm
Abstract: Different standards to measure the sound power of a machine can be chosen. Historically, in a place with extremely loud background noise, the intensity standard (UNE-EN ISO 9614-X) has been used because there is not enough signal-to-noise relation for the pressure method (UNE-EN ISO 374x). Nevertheless, in some cases, the interfering intensity will make the measurement impossible. To solve this problem for both techniques, a new methodology based on the use of blind source separation algorithms is proposed in order to allow an estimation of the signals of the primary sources from some mixed signals and, therefore, to calculate the sound power of the machine of interest. To make the estimated signals as similar as possible to the real signals of the machine under test, different preprocessing techniques (FFT, DCT, cepstrum or wavelets) have been used before the blind source separation algorithms. Once the tests have been conducted for every machine, it is possible to establish at least one process, or combination to obtain results similar to those obtained using the international standards. Finally, since the signals can be scaled at the output of the blind source separation algorithms, one possible signal correction scheme is analyzed.
Published: 2016

223. Managing Carbon on Federal Public Lands: Opportunities and Challenges in Southwestern Colorado

Author: D. Fernandez, Jana B. Milford, Jason C. Neff, Yin D. Huang, Lisa Dilling, and Katharine C. Kelsey
Subjects: 0106 biological sciences, Conservation of Natural Resources, Colorado, 010504 meteorology & atmospheric sciences, Public land, Climate Change, Decision Making, Forest management, Land management, Climate change, Context (language use), Forests, 010603 evolutionary biology, 01 natural sciences, Decision Support Techniques, Trees, Government Agencies, 0105 earth and related environmental sciences, Global and Planetary Change, Ecology, business.industry, Ownership, Environmental resource management, Forestry, Vegetation, Models, Theoretical, Pollution, Carbon, United States, Geography, Work (electrical), Stewardship, business
Abstract: Federal lands in the United States have been identified as important areas where forests could be managed to enhance carbon storage and help mitigate climate change. However, there has been little work examining the context for decision making for carbon in a multiple-use public land environment, and how science can support decision making. This case study of the San Juan National Forest and the Bureau of Land Management Tres Rios Field Office in southwestern Colorado examines whether land managers in these offices have adequate tools, information, and management flexibility to practice effective carbon stewardship. To understand how carbon was distributed on the management landscape we added a newly developed carbon map for the SJNF–TRFO area based on Landsat TM texture information (Kelsey and Neff in Remote Sens 6:6407–6422. doi: 10.3390/rs6076407 , 2014). We estimate that only about 22 % of the aboveground carbon in the SJNF–TRFO is in areas designated for active management, whereas about 38 % is in areas with limited management opportunities, and 29 % is in areas where natural processes should dominate. To project the effects of forest management actions on carbon storage, staff of the SJNF are expected to use the Forest Vegetation Simulator (FVS) and extensions. While identifying FVS as the best tool generally available for this purpose, the users and developers we interviewed highlighted the limitations of applying an empirically based model over long time horizons. Future research to improve information on carbon storage should focus on locations and types of vegetation where carbon management is feasible and aligns with other management priorities.
Published: 2016

224. Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure

Author: Ming Shen, Michael Davis, Udit Agarwal, Janet D. Fernandez, Brian Kogon, Kristin M. French, Milton E. Brown, David Trac, Alex George, Archana V. Boopathy, Amanda Walker Smith, Baahaldin Alsoufi, Kirk R. Kanter, Manu O. Platt, Rong Jiang, and Mary B. Wagner
Subjects: 0301 basic medicine, Aging, Pathology, medicine.medical_treatment, 030204 cardiovascular system & hematology, Pediatrics, Computational biology, 0302 clinical medicine, Cells, Cultured, Ejection fraction, Ventricular Remodeling, Stem Cells, General Medicine, Stem-cell therapy, 3. Good health, medicine.anatomical_structure, Child, Preschool, Progenitor cell, Cardiology, Rats, Transgenic, Stem cell, Adult, Heart Defects, Congenital, Cardiac function curve, medicine.medical_specialty, Heart failure, Rats, Nude, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Ventricular remodeling, Cell Proliferation, business.industry, Myocardium, Infant, Newborn, Infant, Cell Biology, Tissue-Specific Progenitor and Stem Cells, medicine.disease, Rats, 030104 developmental biology, Ventricle, Cell transplantation, business, Stem Cell Transplantation, Developmental Biology
Abstract: To investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling, the authors injected neonate, infant, or child hCPCs into rats with right ventricular heart failure. Mechanisms including migration and proliferation assays, as suggested by computational modeling, showed improved chemotactic and proliferative capacity of neonatal hCPCs compared with infant or child hCPCs. Thus, the reparative potential of hCPCs is age-dependent., Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years). Adolescent athymic rats were subjected to sham or pulmonary artery banding surgery to generate a model of right ventricular (RV) heart failure. Two weeks after surgery, hCPCs were injected in RV musculature noninvasively. Analysis of cardiac function 4 weeks post-transplantation demonstrated significantly increased tricuspid annular plane systolic excursion and RV ejection fraction and significantly decreased wall thickness and fibrosis in rats transplanted with neonatal hCPCs compared with saline-injected rats. Computational modeling and systems biology analysis were performed on arrays and gave insights into potential mechanisms at the microRNA and gene level. Mechanisms including migration and proliferation assays, as suggested by computational modeling, showed improved chemotactic and proliferative capacity of neonatal hCPCs compared with infant/child hCPCs. In vivo immunostaining further suggested increased recruitment of stem cell antigen 1-positive cells in the right ventricle. This is the first study to assess the role of hCPC age in juvenile RV heart failure. Interestingly, the reparative potential of hCPCs is age-dependent, with neonatal hCPCs exerting the maximum beneficial effect compared with infant and child hCPCs. Significance Stem cell therapy for children with congenital heart defects is moving forward, with several completed and ongoing clinical trials. Although there are studies showing how children differ from adults, few focus on the differences among children. This study using human cardiac progenitor cells shows age-related changes in the reparative ability of cells in a model of pediatric heart failure and uses computational and systems biology to elucidate potential mechanisms.
Published: 2016

225. Fibrin Network Changes in Neonates after Cardiopulmonary Bypass

Author: Janet D. Fernandez, Nina A. Guzzetta, Thomas H. Barker, Ashley C. Brown, Lucas H. Timmins, and Riley H. Hannan
Subjects: Adult, Male, medicine.medical_specialty, Blood Loss, Surgical, Context (language use), 030204 cardiovascular system & hematology, Fibrinogen, Fibrin, law.invention, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, law, Blood product, medicine, Cardiopulmonary bypass, Humans, Blood Transfusion, Blood Coagulation, Fetus, Cardiopulmonary Bypass, Microscopy, Confocal, Factor XIII, biology, business.industry, Infant, Newborn, Infant, Cardiac surgery, Anesthesiology and Pain Medicine, Cryoprecipitate, Anesthesia, biology.protein, Female, Prothrombin, business, circulatory and respiratory physiology, medicine.drug
Abstract: Background Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until 1 yr of age. The consequences of “fetal” fibrinogen on clot structure in neonates, particularly in the context of surgery-associated bleeding, have not been well characterized. Here, the authors examine the sequential changes in clotting components and resultant clot structure in a small sample of neonates undergoing cardiac surgery and cardiopulmonary bypass (CPB). Methods Blood samples were collected from neonates (n = 10) before surgery, immediately after CPB, and after the transfusion of cryoprecipitate (i.e., adult fibrinogen component). Clots were formed from patient samples or purified neonatal and adult fibrinogen. Clot structure was analyzed using confocal microscopy. Results Clots formed from plasma obtained after CPB and after transfusion were more porous than baseline clots. Analysis of clots formed from purified neonatal and adult fibrinogen demonstrated that at equivalent fibrinogen concentrations, neonatal clots lack three-dimensional structure, whereas adult clots were denser with significant three-dimensional structure. Clots formed from a combination of purified neonatal and adult fibrinogen were less homogenous than those formed from either purified adult or neonatal fibrinogen. Conclusions The results of this study confirm that significant differences exist in clot structure between neonates and adults and that neonatal and adult fibrinogen may not integrate well. These findings suggest that differential treatment strategies for neonates should be pursued to reduce the demonstrated morbidity of blood product transfusion.
Published: 2016

226. Mechanical damage evaluation of geosynthetics fibres used as anti-reflective cracking systems in asphalt pavements

Author: Jose Norambuena-Contreras, I. Gonzalez-Torre, C. Lopez-Riveros, and D. Fernandez-Arnau
Subjects: Materials science, 0211 other engineering and technologies, Compaction, 02 engineering and technology, Building and Construction, Cracking, Synthetic fiber, Asphalt, 021105 building & construction, Ultimate tensile strength, General Materials Science, Geotechnical engineering, Geosynthetics, Composite material, Anti reflective, Dynamic compaction, 021101 geological & geomatics engineering, Civil and Structural Engineering
Abstract: Geosynthetics are composite materials usually employed as anti-reflective cracking systems in asphalt pavements. However, materials that compose geosynthetics can be damaged due to mechanical and thermal effects produced during the installation process under Hot Mix Asphalts (HMAs). Although different studies have been carried out with the aim of evaluating the damage due to installation on geosynthetics, it is still not clear which variables have more influence on the deterioration of these materials and on the reduction of their properties. Therefore, the main objective of this paper was to evaluate the physical and mechanical damage produced on fibres of geosynthetics used as anti-reflective cracking systems in asphalt pavements. With this purpose, a new procedure to simulate in laboratory conditions the damage produced by the spread and compaction of a HMA on geosynthetics has been developed, by using dynamic compaction of aggregates at high temperatures. Thus, this procedure experimentally simulates the thermal and mechanical loads that geosynthetics undergo when they are used as anti-reflective cracking system. Thereby, different synthetic fibres such as polyester, polyvinyl-alcohol and glass fibres have been evaluated under the developed procedure. Finally, the reduction of physical and mechanical properties has been evaluated by using contrast tests, quantifying the damage produced on the fibres of geosynthetics after different deterioration procedures. Main conclusions of this research established that damage procedure using dynamic compaction of aggregates did not significantly reduce mechanical properties of the fibres strings evaluated by tensile tests on the studied geosynthetics. However, these results were different depending on the material that compose the geosynthetics.
Published: 2016

227. Optimizing Thrombin Generation with 4-Factor Prothrombin Complex Concentrates in Neonatal Plasma After Cardiopulmonary Bypass

Author: Kenichi A. Tanaka, Janet D. Fernandez, Fania Szlam, Sarah W. Franklin, Nina A. Guzzetta, and Traci Leong
Subjects: Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Thrombin generation, law.invention, Plasma, 03 medical and health sciences, 0302 clinical medicine, Thrombin, 030202 anesthesiology, law, medicine, Cardiopulmonary bypass, Humans, Prospective Studies, Prospective cohort study, Cardiopulmonary Bypass, business.industry, Infant, Newborn, Perioperative, Plasma Metabolism, Blood Coagulation Factors, Surgery, Anesthesiology and Pain Medicine, Anesthesia, Female, business, Complication, PROTHROMBIN COMPLEX, circulatory and respiratory physiology, medicine.drug
Abstract: Bleeding is a serious complication after pediatric cardiopulmonary bypass (CPB) that is associated with an increase in perioperative morbidity and mortality. Four-factor prothrombin complex concentrates (4F-PCCs) have been used off-label to supplement transfusion protocols for bleeding after CPB in adults; however, data on their use in neonates are limited. In this study, we hypothesized that 4F-PCCs administered ex vivo to neonatal plasma after CPB will increase thrombin generation.Fifteen neonates undergoing complex cardiac repairs requiring CPB were enrolled in this prospective study. Arterial blood was obtained after anesthesia induction but before CPB (baseline), after CPB following heparin reversal, and after our standardized transfusion of a quarter of a platelet apheresis unit (approximately 20 mL·kg) and 3 units of cryoprecipitate. Kcentra (CSL Behring), a 4F-PCC with nonactivated factor VII (FVII), and factor 8 inhibitor bypassing activity (FEIBA; Baxter Healthcare Corporation), a 4F-PCC with activated FVII, were added ex vivo to plasma obtained after CPB to yield concentrations of 0.1 and 0.3 IU·mL. Calibrated automated thrombography was used to determine thrombin generation for each sample.The addition of Kcentra to plasma obtained after CPB resulted in a dose-dependent increase in the median (99% confidence interval) peak amount of thrombin generation (42.0 [28.7-50.7] nM for Kcentra 0.1 IU·mL and 113.9 [99.0-142.1] nM for Kcentra 0.3 IU·mL). The rate of thrombin generation was also increased (15.4 [6.5-24.6] nM·min for Kcentra 0.1 IU·mL and 48.6 [29.9-66.6] nM·min for Kcentra 0.3 IU·mL). The same was true for FEIBA (increase in peak: 39.8 [27.5-49.2] nM for FEIBA 0.1 IU·mL and 104.6 [92.7-124.4] nM for FEIBA 0.3 IU·mL; increase in rate: 17.4 [7.4-28.8] nM·min FEIBA 0.1 IU·mL and 50.5 [26.7- 63.1] nM·min FEIBA 0.3 IU·mL). In the posttransfusion samples, there was a significant increase with Kcentra in the median (99% confidence interval) peak amount (41.1 [21.0-59.7] nM for Kcentra 0.1 IU·mL and 126.8 [106.6- 137.9] nM for Kcentra 0.3 IU·mL) and rate (18.1 [-6.2 to 29.2] nM·min for Kcentra 0.1 IU·mL and 53.2 [28.2-83.1] nM·min for Kcentra 0.3 IU·mL) of thrombin generation. Again, the results were similar for FEIBA (increase in peak: 43.0 [36.4-56.7] nM for FEIBA 0.1 IU·mL and 109.2 [90.3-136.1] nM for FEIBA 0.3 IU·mL; increase in rate: 25.0 [9.1-32.6] nM·min for FEIBA 0.1 IU·mL and 59.7 [38.5-68.7] nM·min for FEIBA 0.3 IU·mL). However, FEIBA produced in a greater median reduction in lag time of thrombin generation versus Kcentra in samples obtained after CPB (P = 0.003 and P = 0.0002 for FEIBA versus Kcentra at 0.1 and 0.3 IU·mL, respectively) and in samples obtained after transfusion (P0.0001 for FEIBA versus Kcentra at 0.1 and 0.3 IU·mL).After CPB, thrombin generation in neonatal plasma was augmented by the addition of 4F-PCCs. The peak amount and rate of thrombin generation were enhanced in all conditions, whereas the lag time was shortened more with FEIBA. Our findings suggest that the use of 4F-PCCs containing activated FVII may be an effective adjunct to the initial transfusion of platelets and cryoprecipitate to augment coagulation and control bleeding in neonates after CPB.
Published: 2016

228. Hypersensitivity Reactions to Fluoroquinolones

Author: María José Torres, Immaculada Andreu, Maria Salas, Tahia D. Fernandez, Arturo Ruiz, Cristobalina Mayorga, and Esther Barrionuevo
Subjects: Allergy, biology, business.industry, Provocation test, Medicine (miscellaneous), Immunoglobulin E, medicine.disease, medicine.disease_cause, Cross-reactivity, 030207 dermatology & venereal diseases, 03 medical and health sciences, Basophil activation, 0302 clinical medicine, 030228 respiratory system, Antigen, In vivo, Immunology, biology.protein, medicine, False positive paradox, Immunology and Allergy, business
Abstract: Fluoroquinolones (FQs) are important antibiotics for the treatment of a wide range of infectious diseases. However, while FQs are generally well-tolerated, both IgE and T cell-mediated hypersensitivity reactions can occur. Moreover, there has been an increase in the prevalence of these reactions in recent decades, probably due to higher levels of consumption. The diagnosis of allergy to FQs is complex and is based on clinical history, skin tests (STs), and determination of the drug-specific IgE using both immunoassays and basophil activation tests (BATs). However, these approaches have sub-optimal sensitivity and specificity: clinical history can be unreliable and overestimate the incidence of reactions, STs show a high rate of false positives, and in vitro tests have low sensitivity. Therefore, drug provocation testing is currently the best method to establish diagnosis; however, it carries certain risks and should be avoided for cases with a history of severe reactions. In order to improve the sensitivity and specificity of in vivo and in vitro methods, it is crucial to fully characterize the FQ antigenic determinants that are recognized by the immunological system. Current data indicate that groups at the C2–C6 positions of their chemical structure may form part of the antigenic determinant recognized by IgE. Moreover, their photostability can affect protein reactivity and therefore the formation of the hapten-carrier. All of these factors influence IgE and T cell recognition, the clinical response, and cross-reactivity and are the key for improving diagnostic methods. Additionally, a previous diagnosis of hypersensitivity to β-lactams has been reported to be a risk factor for FQ hypersensitivity, and this significantly decreases the therapeutic options for treating infectious diseases. Therefore, further studies are needed to obtain an accurate diagnosis, taking into account cross-reactivity, and to find alternative treatments.
Published: 2016

229. Public health competencies and contents in Spanish undergraduate medical degrees

Author: Carmen Vives-Cases, Maria Pastor-Valero, Miguel Ruiz-Canela, Angel Asunsolo del Barco, M. Carmen Davo-Blanes, Pere Godoy, Carlos Aibar Remón, Luis Félix Valero Juan, Miquel Porta, Joan D. Fernandez-Ballart, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, and Salud Pública
Subjects: Medical education, medicine.medical_specialty, Medicina, Population, Psychological intervention, Competencias profesionales, Health administration, 03 medical and health sciences, 0302 clinical medicine, Salud pública, Educación médica, medicine, 030212 general & internal medicine, education, Curriculum, Health policy, Universidad, Public health, University, education.field_of_study, lcsh:Public aspects of medicine, 030503 health policy & services, Public Health, Environmental and Occupational Health, Core competency, lcsh:RA1-1270, Competències professionals, Universitats -- Espanya, Medicina Preventiva y Salud Pública, Professional competencies, Medicine, Educació mèdica -- Espanya, 0305 other medical science, Psychology, Working group
Abstract: Objetivo: Consensuar las competencias profesionales de salud pública que deben adquirir los estudiantes en el Grado en Medicina y los contenidos fundamentales que debe incluir la materia de salud pública según el criterio de un grupo de docentes de salud pública del Grado en Medicina de distintas universidades españolas. Métodos: Se organizó una 2 ª Reunión del Foro de Profesorado Universitario de Salud Pública en la Universidad Rey Juan Carlos (Madrid, 11-12 de diciembre de 2014), en la que participaron 24 docentes de 19 universidades españolas con Grado en Medicina que fueron distribuidos en tres grupos durante tres sesiones de trabajo. En la primera sesión, se identificaron y clasificaron las competencias propias del Grado; en la segunda, se propusieron contenidos de salud pública para las competencias identificadas; en la tercera, se organizaron los contenidos en bloques temáticos. Los resultados se discutieron hasta alcanzar acuerdos, en distintas sesiones plenarias. Resultados: El mayor número de competencias identificadas corresponde a actividades de las funciones «Valorar las necesidades de salud de la población» y «Desarrollar políticas de salud». El programa final incluye contenidos básicos organizados en cinco bloques: Concepto de salud, salud pública y sus condicionantes; Epidemiología e investigación en salud; Condicionantes y problemas de salud; Estrategias, intervenciones y políticas; y Sistemas de salud, gestión clínica y sanitaria. Conclusiones: Las competencias y los contenidos comunes consensuados en este Foro constituyen una base para actualizar y mejorar la formación en salud pública de los futuros profesionales de la medicina. Objective: To reach a consensus among public health faculty from various Spanish universities about the core public health competencies that should be integrated into undergraduate medical degrees. Methods: The 2 nd Forum of University Teachers was held at the Rey Juan Carlos University (Madrid, 11-12 December 2014). Twenty-four university professors and lecturers from 19 Spanish universities imparting medical degrees participated in the forum. They were distributed in three working groups during three working sessions. In the first session, they were asked to identify and classify core public health competencies for medical degrees. In the second, they were asked to propose public health contents for the identified competencies. In the third session, the participants organized these contents in thematic blocks. The results were discussed in distinct plenary sessions. Results: The highest number of core competencies was identified in the activities related to the public health functions «Assessment of the population's health needs» and «Developing health policies». The final programme included basic contents organised into five units: Concept of health, public health and its determinants; Epidemiology and health research; Determinants and health problems; Strategies, interventions and policies; and health systems, clinical and healthcare management. Conclusions: The public health core competencies and contents identified in this Forum may be considered as a starting point to improve and update public health training programmes for future medical professionals. La Fundación Dr. Antonio Esteve patrocinó la 2ª Reunión del Foro de Profesorado Universitario de Salud Pública en el Grado de Medicina. Este foro forma parte de las actividades realizadas por el Grupo de Trabajo de Formación de los Profesionales de la Salud Pública auspiciado por SEE-SESPAS.
Published: 2016

230. Impact of at-home self-rehabilitation of the perineum on pelvic floor function in patients with stress urinary incontinence: Results from a prospective study using three-dimensional ultrasound

Author: Hervé Fernandez, J.-M. Levaillant, Guillaume Legendre, Florent Fuchs, D. Fernandez, and A. Gonzalves
Subjects: Adult, medicine.medical_specialty, Urinary Incontinence, Stress, medicine.medical_treatment, 030232 urology & nephrology, Urinary incontinence, Perineum, Perineal Muscle, Pelvic Floor Muscle, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, medicine, Humans, Prospective cohort study, Ultrasonography, 030219 obstetrics & reproductive medicine, Pelvic floor, Rehabilitation, business.industry, Obstetrics and Gynecology, Pelvic Floor, General Medicine, Middle Aged, Home Care Services, Exercise Therapy, Surgery, Self Care, Treatment Outcome, Levator ani, medicine.anatomical_structure, Reproductive Medicine, Quality of Life, Physical therapy, Female, medicine.symptom, business
Abstract: Summary Objective Pelvic floor muscle training (PFMT) is the first step of treatment for stress urinary incontinence (SUI). Patients must perform self-retraining exercises of the perineal muscles at home in order to maintain the benefit of the physiotherapy. The aim of this study is to assess the benefit of a perineal electro-stimulator, using three-dimensional ultrasound, during this home-care phase. Materials and methods A longitudinal prospective study was conducted between May 2012 and May 2013. All patients with de novo SUI benefited from PFMT followed by a self-maintenance of perineal rehabilitation at home with the Keat ® Pro system. The primary endpoint was the biometric of the levator ani and it was assessed by three-dimensional perineal ultrasound at inclusion, after conventional rehabilitation and at the end of the study after self-rehabilitation. Results Ten patients were included. All patients (100%) showed a clinical improvement of SUI. The quality of life was significantly improved after PFMT vs. inclusion ( P = 0.014) and after self-rehabilitation vs. after PFMT ( P = 0.033). Levator ani muscles were significantly thicker after conventional rehabilitation than at baseline ( P = 0.004) and significantly thicker after self-rehabilitation than after PFMT ( P = 0.009). Conclusions Conducting self-rehabilitation in addition to conventional PFMT objectively improves the perineal muscle building achieved after conventional rehabilitation.
Published: 2016

231. The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid

Author: Adriana Ariza, Maria I. Montañez, M. Blanca, M.J. Torres, Maria Salas, Nekane Barbero, Cristobalina Mayorga, and Tahia D. Fernandez
Subjects: 0301 basic medicine, Allergy, Immunology, Immunoglobulin E, Benzylpenicillin, Epitope, Drug Hypersensitivity, 03 medical and health sciences, 0302 clinical medicine, Antigen, Immunochemistry, medicine, Humans, Immunology and Allergy, Clavulanic Acid, Sensitization, biology, Amoxicillin, medicine.disease, Anti-Bacterial Agents, Penicillin, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, biology.protein, medicine.drug
Abstract: Betalactam (BL) antibiotics are the drugs most frequently involved in IgE-mediated reactions. The culprit BL varies according to consumption patterns, with amoxicillin (AX) more prevalent in Southern Europe and penicillin V in Scandinavian countries. Nowadays, the combination of AX and clavulanic acid (CLV) is the most highly consumed BL containing medicine worldwide. Both BLs, AX and CLV, can independently be involved in reactions, which poses a diagnostic challenge. In patients with immediate allergic reactions to AX, two patterns of responses have been described, those responding to benzylpenicillin (cross-reactors) and those selective to AX. In addition, selective reactions to CLV account for around 30% of allergic reactions to the combination AX-CLV. These patterns of IgE recognition could be related to differences in the haptenation process, in the immunological response, or in the BL involved in the first sensitization. In this regard, patients with selective responses to CLV are generally younger than those allergic to AX or benzylpenicillin. So far, no evidence of cross-reactivity between CLV and other BLs has been reported. This shows the importance of an accurate diagnosis of CLV allergy, as patients with selective reactions to CLV could take other BLs including AX. Diagnosis can be performed in vivo and in vitro, although no immunoassay currently exists. Research regarding the CLV antigenic determinants and protein conjugates is essential to improve diagnosis. BLs need to covalently bind to a carrier protein to be immunogenic. The antigenic determinant of AX is the amoxicilloyl amide, but CLV leads to unstable structures, many of which are unknown. Moreover, the nature of the BL-protein conjugates plays an important role in IgE recognition. This review aims to summarize current knowledge on the immunochemistry, diagnostic approaches as well as chemical and proteomic studies for both AX and CLV.
Published: 2016

232. Prediction of Skeletal Medial-Lateral for transfemoral ischial containment sockets

Author: Bircan Erbas, Christopher A. Briggs, Matthew Quigley, Michael P Dillon, and Richard G D Fernandez
Subjects: Adult, Male, 030506 rehabilitation, Artificial Limbs, Amputation, Surgical, Young Adult, 03 medical and health sciences, Standard anatomical position, 0302 clinical medicine, Cadaver, Prosthesis Fitting, Bayesian multivariate linear regression, medicine, Humans, Femur, Pelvic Bones, Pelvis, Aged, Aged, 80 and over, Orthodontics, Leg, Trochanter, business.industry, Rehabilitation, Anatomy, Middle Aged, Standard error, medicine.anatomical_structure, Female, Anatomic Landmarks, Tomography, X-Ray Computed, 0305 other medical science, Cadaveric spasm, business, 030217 neurology & neurosurgery
Abstract: Accurate measurement of the pelvis is critical for well-fitting and comfortable ischial containment sockets. The "Skeletal Medial-Lateral (ML)" is intrusive and unreliable to measure in vivo. This study aimed to determine how accurately the Skeletal ML could be predicted and to identify which measurements were significant predictors. Computed tomography scans were randomly sampled from a cadaveric database (n = 200). Inclusion criteria were age > 20 yr; lower-limb alignment that replicated the anatomical position; and no evidence of osteological trauma, implants, or bony growths. Multivariate linear regression models were developed to predict the Skeletal ML based on a suite of independent variables, including sex, body mass, and distance between pelvic landmarks. The regression model explained 76% of the variance in the Skeletal ML (p < 0.001). Variables that contributed significantly to the prediction of the Skeletal ML (p < 0.05) included body mass, sex, inter-greater trochanter distance, pelvic depth, and age. Significant predictors of the Skeletal ML dimension characterize variation in subcutaneous adipose tissue thickness and pelvic morphology. The Skeletal ML could be predicted with relatively small errors (standard error of the estimate = 7 mm) that could be easily and reliably adjusted during socket fitting. Further research is needed to test the predictive tool in a real-world setting.
Published: 2016

233. Differences Between Road Traffic and Leisure Noise in Urban Areas. Developing a Model for Automatic Identification

Author: Jose A. Ballesteros, Antonio J. Torija, Marcos D. Fernandez, and Mª Jesús Ballesteros Garrido
Subjects: Acoustics and Ultrasonics, Urban agglomeration, Computer science, Noise pollution, 020208 electrical & electronic engineering, Control (management), Regression analysis, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Transport engineering, Support vector machine, Identification (information), Noise, 0202 electrical engineering, electronic engineering, information engineering, Environmental noise, Music, 0105 earth and related environmental sciences
Abstract: Leisure and road traffic are two of the major contributors to environmental noise in urban agglomerations. This environmental problem is particularly important in some cities, where there is a massive circulation of traffic vehicles and numerous outdoor social activities with a leisure noise mainly composed by human-related sounds. Due to the apparent differences between human-related sounds and road traffic sounds, the descriptors used to approach a proper evaluation of leisure noise may not be the same as the ones used for road traffic noise evaluation. This paper is aimed at analyzing the road traffic and leisure noise characteristics and the most important parameters to study and evaluate both noise sources. Therefore, as usually both noise sources are mixed, a model has been developed and tested which, when provided an environmental noise measurement, will be able to identify what kind of noise (leisure or road traffic noise) is dominant in a given environment. This model, done by using Support Vector Machines (SVMs) and Regression Analysis algorithms, allows focusing the abatement actions towards the noise source identified as dominant, and thus, addressing a better management and a proper control of the environmental noise in urban environments.
Published: 2016

234. The 47th Annual Meeting of the American Pancreatic Association

Author: Ashok K. Saluja, Maria D. Fernandez, Jennifer B. Carney, and Vay Liang W. Go
Subjects: Gerontology, Service (business), medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Association (object-oriented programming), MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030220 oncology & carcinogenesis, Family medicine, Internal Medicine, medicine, 030211 gastroenterology & hepatology, business
Published: 2017

235. PO-0812: Hypofractionated Chemoradiation in LAHNC; QOL, Toxicity and Local Control in Radiation courses

Author: L. Caussa, D. Fernandez, F. Díaz Vazquez, G. Ferraris, and D. Davalos
Subjects: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Toxicity, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, business
Published: 2020

236. THU0142 CHARACTERISTICS OF OSTEOPOROTICAL WOMEN IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS

Author: I. Braña Abascal, J. Malave Calzada, R. Veroz Gonzalez, M. D. C. Carrasco Cubero, S. M. Rojas Herrera, J. J. Aznar Sanchez, M. Priego Fernandez-Martos, L. M. Chaves Chaparro, D. Fernandez Lozano, and E. Chamizo Carmona
Subjects: education.field_of_study, medicine.medical_specialty, FRAX, business.industry, Immunology, Osteoporosis, Population, Disease, medicine.disease, General Biochemistry, Genetics and Molecular Biology, medicine.anatomical_structure, Rheumatology, Rheumatoid arthritis, Internal medicine, Cohort, Immunology and Allergy, Medicine, Observational study, business, education, Femoral neck
Abstract: Background:The estimated prevalece of osteporosis in lumbar spine in women over 50 years is around 22.8% of the general population. In women with rheumatoid arthritis (RA), osteoporosis (OP) is more prevalent and begins at earlier ages.Objectives:The aim of this study is to assess the effect of different risk factors in the development of OP in women with RA.Methods:This is an observational study in women diagnosed of RA according ACR criteria 1987 and 2010, in order to know the influence of different clinical features in the development of OP. Between 2013 and 2109 we offer all women diagnosed of RA to participate in the study and perform an BMD (GE Lunar Prodigy®). SPSS25 was used for statistical analysis.Results:We enrolled 295 women with RA. Mean age 62,4 (± 11,6) years old and average duration of the disease of 118,3 (±98,8) months. Table 1 shows the clinical features of the studied population. BMD was normal in 66 woman (22,4%), therefore 229 (77,6%) y 85 (28,8%) had BMD values less than -1 y -2.5, respectively in femoral neck and/or lumbar spine. Major risk fracture and hip risk fracture (FRAX DMO) was hight in 49,2 y 40,2% of the RA patients, of which almost 15% had a fracture [OR 7,6 (3,1-18,9) pTable 1.Clinical featuresAge RA, years (SD)52,54 (13,21)Height, cm (SD)153,72 (7,54)Weight, kg (SD)70,04 (14,39)Smokers, n (%)33 (11,3)OH-vit D2 21 (7,8)RF +, n (%)219 (76,6)ACPA +, n (%)187 (65,4%)Corticosteroids, n (%)191 (64,7%)Biologics treatment, n (%)75 (25,4%)MBD normal66 (22,4%)MBD lumbar spine CL 175 (59,3%)MBD femoral neck 192 (65,8%)MBD lumbar spine 60 (20,5%)MBD femoral neck 55 (18,8%)Fractures, n (%)43 (14,7%)Major risk fracture (FRAX), n (%)125 (49,2%)Femoral head risk fracture (FRAX), n (%)102 (40,2%)Conclusion:OP and fragility fractures occur earlier and higher in women with RA. BD T-score in femoral neck seems to be the best predictor of fracture.Disclosure of Interests:None declared
Published: 2020

237. AB0748 IMPORTANCE OF COMORBIDITIES IN PATIENTS WITH ARTHRITIS PSORIATIC

Author: J. J. Aznar Sanchez, J. Malave Calzada, M. Priego Fernandez-Martos, D. Fernandez Lozano, R. Veroz Gonzalez, E. Chamizo Carmona, I. Braña Abascal, and S. M. Rojas Herrera
Subjects: education.field_of_study, medicine.medical_specialty, Heart disease, business.industry, Immunology, Population, Overweight, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Internal medicine, Diabetes mellitus, Cohort, medicine, Immunology and Allergy, Hyperuricemia, Metabolic syndrome, medicine.symptom, business, education, Depression (differential diagnoses)
Abstract: Background:Cardiovascular diseases are more prevalent in inflammatory arthritis, such as psoriatic arthropathy (PsA), than in general population. An increase in the presence of anxiety-depressive disorders has been also described in patients with psoriatic disease.Objectives:To assess the prevalence of comorbilities in a cohort of patient with PsA, especially cardiovascular events and anxiety-depression disorders.Methods:Observational, cross- sectional study of a cohort of patients with PsA from a monographic clinical unit in a rheumatology department to describe the presence of comorbidities: hypertension, diabetes, hyperlipemia, hyperuricemia, smoking, obesity, depression and isquemic heart disease (IHD). The comorbidities were analyzed according to the type of disease: peripheral, mixed and axial involvement. For statistical analysis SPSS v.25 was used.Results:We included 145 patients: 84 men and 61 women. The mean age at diagnosis was 45,4 (± 12,9) years, and the mean time of evolution was 9.3 (± 6,2) years. No significant difference between genders was observed.Peripheral involvement was observed in 94 (64,8%), mixed 31 (21,4%) and axial involvement in 20 (13,8%). We did not find any differences between gender for peripheral and axial pattern, however 31% of men versus 8,2% of women presented a mixed pattern. [OR=5 (1,8-14), p= 0,001].The most common comorbidities founded were hyperlipemia, overweight and arterial hypertension. Table 1 shows all the comorbidities studied and their distribution by pattern.Patients with mixed involvement had a higher proportion of smokers [OR=2,9 (1,2-7,3), p=0,02] and a tendency to higher IHD [OR=2,8 (0,9-8,6), p=0,06].Overweight was significantly lower in axial pattern patients [OR=0,4 (0,2-0,8), p=0,01] and higher in the peripheral ones [OR=1,5 (1,1-2,1), p=0,01].IHD was prevalent in patients of our cohort (10,3%), it was significantly higher in men than in women [OR=12 (1,5-93,9), p=0,003], and more likely in mixed involvement (19,4%).Males with PsA also developed hyperuricemia more frequently [OR=6,5 (2,5-16,9), pConclusion:In our cohort, a high prevalence of comorbidities was found, especially hyperlipemia, metabolic syndrome and IHD. In general, overweight (BMI > 25) was very common and was associated to a peripheral disease while the axial disease showed as a protective factor.Table 1.Comorbilities in patterns of disease.PsA (n=145)Peripheral disease (n=94)Mixed disease(n=31)Axial disease(n=20)Age at diagnosis, year (DE)45,4 (±13)45,7 (±12,9)45 (±13)43,9 (±13,8)Time of evolution, years (DE)9,3 (±6,2)9,6 (±6,5)8,6 (±5,4)7,3 (±2,9)Men, n (%)84 (57,9%)48 (51,1%)26 (83,9%)10 (50%)Women n (%)61 (42,1%)46 (48,9%)5 (16,1%)10 (50%)Hyperlipemia, n (%)87 (60%)60 (63,8%)17 (54,8%)10 (50%)BMI >25, n (%)83 (57,2%)61 (64,9%)15 (48,4%)7 (35%)Hypertension, n (%)46 (31,7%)28 (29,8%)13 (41,9%)5 (25%)Hyperuricemia, n (%)41 (28,3%)25 (26,6%)11 (35,5%)5 (25%)Diabetes, n (%)27 (18,6%)20 (21,3%)6 (19,4%)1 (5%)Smokers, n (%)26 (17,9%)13 (13,8%)10 (32,3%)3 (15%)Depression, n (%)23 (15,9%)16 (17%)6 (19,4%)1 (5%)Metabolic syndrome n (%)23 (15,9%)15 (16%)5 (16%)3 (15%)IHD, n (%)15 (10,3%)7 (7,4%)6 (19,4%)2 (10%)Disclosure of Interests:None declared
Published: 2020

238. AB0255 RISK OF FRAGILITY FRACTURE IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS

Author: M. Priego Fernandez-Martos, D. Fernandez Lozano, M. D. C. Carrasco Cubero, J. Malave Calzada, L. M. Chaves Chaparro, R. Veroz Gonzalez, E. Chamizo Carmona, S. M. Rojas Herrera, I. Braña Abascal, and J. J. Aznar Sanchez
Subjects: medicine.medical_specialty, business.industry, Visual analogue scale, Immunology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, FACIT Fatigue Scale, Correlation, Rheumatology, Rheumatoid arthritis, Sarcopenia, Cohort, medicine, Physical therapy, Immunology and Allergy, Heart rate variability, Observational study, business
Abstract: Background:Rheumatoid Arthritis (RA) is associated with low bone density and hight risk fracture compared to general population.Objectives:The aim of this study is to assess the effect of some variables on fragility fractures in patients with RA.Methods:We perform an observational study in a cohort of patients diagnosed of RA according to 1987 and 2010 ACR criteria, to determine the frequency of osteoporotic fractures and associated clinical and densitometric variables. All patients diagnosed of RA were invited to participate in the study between 2013 and 2019, and to perform BMD DXA (GELunarProdigy®). SPSS25 was used to compare variables between patients with fracture and without fracture.Results:376 patients with RA were included (78,7% women), mean age 63,3 (±13,2) years old and a mean of evolution of the RA of 118,7(±96,7) months at the moment the BMD was performed. We found bone fracture in 47 (12,6%) patients. Fractures were associated to female gender (OR: 2,93 (1,08-7,93); p=0,02), lower height and weight (pTable 1 shows the characteristics and differences between patients with and without fragility fractures. Women presented high risk of osteoporosis in lumbar spine [OR=3,89(1,46-10,37); p=0,002] than men, but any differences between gender were found in BMD of femoral neck. Of the fractured patients, BMD T-score was normal in 2 (4,3%), Table 1.CharacteristicsPatients with fractures (n=47)Patients without fractures (n=327)OR (IC 95%); p valueFemales43 (14,7%)250 (85,3%)2,9 (1,1-7,8); p=0,02Age67,7 (±10,6)62,7 (±11,6)P=0,005Height152,4 (±9,4)157,3 (±8,8)P=0,001Weight66,2 (±16)73,3 (±14,4)P=0,003Smokers8 (12,1%)58 (87,9%)0,9 (0,4-2,1) p=0,89RF (+)35 (12,2%)252 (87,8%)0,9 (0,4-1,7) p=0,66ACPA+30 (12,3%)213 (87,7%)1,3 (0,6-2,8) p=0,44Steroids36 (14,4%)214 (85,6%)1,7 (0,8-3,5) p=0,13Biologics treatment16 (16,2%)83 (83,8%)1,5 (0,8-2,9) p=0,22Bone mineral density (BMD) in lumbar spine34 (16,8)168 (83,2)2,6 (1,3-5,2) p=0,006BMD femoral neck CF43 (17,8)198 (82,2)9,0 (2,7-29,6) pBMD lumbar spine17 (26,6)47 (73,4)3,4 (1,7-6,7) pBMD femoral neck20 (29,4)48 (70,6)4,4 (2,3-8,5) pMajor osteoporotic risk (FRAX)37 (23,6)120 (76,4)7,4 (3,2-17,2) pHip fracture risk (FRAX)34 (24,5)105 (75,5)5,9 (2,8-12,5) pConclusion:Women with RA present higher risk of fracture than men. The most sensitive indicator for fracture risk seems to be MBD in femoral neck.Disclosure of Interests:None declared
Published: 2020

239. Lymphocyte Transformation Test Effectivity based on the Antigen presenting Cells Employed in Immediate Allergic Reactions to Betalactams

Author: Alba Rodríguez-Nogales, M. Salas, Maria Vega, Maria Rodriguez-Sanchez, Maria Francisca Palomares Jerez, Cristobalina Mayorga, Tahia D. Fernandez, Ruben Fernandez-Santamaria, Maria Jose Torres Jaén, Ana Molina Bueno, and Gador Bogas Herrera
Subjects: business.industry, Lymphocyte transformation, Immunology, Immunology and Allergy, Medicine, business, Antigen-presenting cell
Published: 2020

240. Use of Lymphocyte Transformation Test to evaluate the recognition of synthetic Clavulanic Acid antigenic determinants by the immune system

Author: Ezequiel Perez-Inestrosa, Patricia Malagon Conejo, Maria Vega, Ruben Fernandez-Santamaria, Cristobalina Mayorga, Tahia D. Fernandez, Alba Rodríguez-Nogales, and Maria Jose Torres Jaén
Subjects: Immune system, Antigen, Lymphocyte transformation, Clavulanic acid, Immunology, medicine, Immunology and Allergy, Biology, medicine.drug
Published: 2020

241. Emotional intelligence in hepatitis C patients is improved in 8 weeks

Author: Francisco E Ramirez, D. Fernandez, R. Gallant, Neil Nedley, and D. Burkitt
Subjects: Hepatology, business.industry, Emotional intelligence, Gastroenterology, Medicine, Hepatitis C, business, medicine.disease, Clinical psychology
Published: 2020

242. Imagenes de un imperio: Estados y las formas de representacion de America Latina

Author: L'Hoeste, Hector D. Fernandez
Subjects: Imagenes de un imperio: Estados Unidos y las formas de representacion de America Latina (Book) -- Book reviews, Books -- Book reviews, Anthropology/archeology/folklore, History, Social sciences
Published: 2007

243. A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity

Author: Adrián González-López, David Jimeno, Jaime Martín-Benito, Eva María Soriano, José L. Revuelta, Rafael López Núñez, D. Fernandez-Justel, Rubén M. Buey, Ministerio de Economía y Competitividad (España), Martín-Benito, Jaime [0000-0002-8541-4709], Jimeno, David [0000-0001-7876-0083], Revuelta Doval, José Luis [0000-0001-7838-5308], Buey, Ruben M. [0000-0003-1263-0221], Martín-Benito, Jaime, Jimeno, David, Revuelta Doval, José Luis, and Buey, Ruben M.
Subjects: GTP', Guanine, Allosteric regulation, Molecular Conformation, Cytoophidia, Dehydrogenase, X-ray crystallography and scattering, Catalysis, Polymerization, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, IMP Dehydrogenase, Conformational switch, Structural Biology, IMP dehydrogenase, Cell Line, Tumor, medicine, Humans, Nucleotide, Inosine, Molecular Biology, 030304 developmental biology, Cell Proliferation, chemistry.chemical_classification, 0303 health sciences, Nucleotides, Enzyme, chemistry, Biochemistry, Guanosine Triphosphate, 030217 neurology & neurosurgery, medicine.drug, HeLa Cells
Abstract: 36 p.-6 fig.+inf. supl.18 p.-8 fig.-2 tab., Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo GTP biosynthetic pathway and plays essential roles in cell proliferation. As a clinical target, IMPDH has been studied for decades, but it has only been within the last years that we are starting to understand the complexity of the mechanisms of its physiological regulation. Here, we report structural and functional insights into how adenine and guanine nucleotides control a conformational switch that modulates the assembly of the two human IMPDH enzymes into cytoophidia and allosterically regulates their catalytic activity. In vitro reconstituted micron-length cytoophidia-like structures show catalytic activity comparable to unassembled IMPDH but, in turn, are more resistant to GTP/GDP allosteric inhibition. Therefore, IMPDH cytoophidia formation facilitates the accumulation of high levels of guanine nucleotides when the cell requires it. Finally, we demonstrate that most of the IMPDH retinopathy-associated mutations abrogate GTP/GDP-induced allosteric inhibition and alter cytoophidia dynamics., This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (grants BFU2016-79237-P to R.M.B. and BIO2014-56930-P to J.L.R.).
Published: 2018

244. Identification of an antigenic determinant of clavulanic acid responsible for IgE-mediated reactions

Author: Maria Salas, Cristobalina Mayorga, Francisco Najera, Dolores Pérez-Sala, Gador Bogas, Ezequiel Perez-Inestrosa, María José Torres, Angela Martin-Serrano, Tahia D. Fernandez, Nekane Barbero, Ruben Fernandez-Santamaria, Maria I. Montañez, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Mayorga, Cristobalina, Martín-Serrano, Ángela, Nájera, Francisco, Salas, María, Pérez-Sala, Dolores, Pérez-Inestrosa, Ezequiel, Fernández, Tahia, Montañez, M. I., Torres, María J., Mayorga, Cristobalina [0000-0001-8852-8077], Martín-Serrano, Ángela [0000-0002-2908-8910], Nájera, Francisco [0000-0002-1635-5514], Salas, María [0000-0002-0583-9492], Pérez-Sala, Dolores [0000-0003-0600-665X], Pérez-Inestrosa, Ezequiel [0000-0001-7546-5273], Fernández, Tahia [0000-0003-0625-2156], Montañez, M. I. [0000-0001-6641-5979], and Torres, María J. [0000-0003-4499-840X]
Subjects: 0301 basic medicine, Drug, Hypersensitivity, Immediate, Models, Molecular, In vitro test, in vitro test, media_common.quotation_subject, Immunology, Molecular Conformation, Immunoglobulin E, Epitope, Immediate reactions, 03 medical and health sciences, Epitopes, Structure-Activity Relationship, 0302 clinical medicine, Antigen, Tandem Mass Spectrometry, medicine, Immunology and Allergy, Humans, clavulanic acid, immediate reactions, Clavulanic Acid, media_common, biology, medicine.diagnostic_test, Chemistry, Drug allergy, Human serum albumin, In vitro, Basophils, Basophil activation, 030104 developmental biology, 030228 respiratory system, ROC Curve, Immunoassay, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, IgE, drug allergy, medicine.drug, Chromatography, Liquid
Abstract: 12 p.-6 fig.-1 graf. abst., BACKGROUND: Selective reactions to clavulanic acid (CLV) account for around 30% of immediate reactions after administration of amoxicillin-CLV. Currently, no immunoassay is available for detecting specific IgE to CLV, and its specific recognition in patients with immediate reactions has only been demonstrated by basophil activation testing, however with suboptimal sensitivity. The lack of knowledge regarding the structure of the drug that remains bound to proteins (antigenic determinant) is hampering the development of in vitro diagnostics. We aimed to identify the antigenic determinants of CLV as well as to evaluate their specific IgE recognition and potential role for diagnosis., METHODS: Based on complex CLV degradation mechanisms, we hypothesized the formation of two antigenic determinants for CLV, AD-I (N-protein, 3-oxopropanamide) and AD-II (N-protein, 3-aminopropanamide), and designed different synthetic analogs to each one. IgE recognition of these structures was evaluated in basophils from patients with selective reactions to CLV and tolerant subjects. In parallel, the CLV fragments bound to proteins were identified by proteomic approaches., RESULTS: Two synthetic analogs of AD-I were found to activate basophils from allergic patients. This determinant was also detected bound to lysines 195 and 475 of CLV-treated human serum albumin. One of these analogs was able to activate basophils in 59% of patients whereas CLV only in 41%. Combining both results led to an increase in basophil activation in 69% of patients, and only in 12% of controls., CONCLUSION: We have identified AD-I as one CLV antigenic determinant, which is the drug fragment that remains protein-bound., The present study has been supported by Institute of Health “Carlos III” of the Ministry of Economy and Competitiveness (grants cofunded by European Regional Development Fund (ERDF): PI12/02529, PI15/01206, CP15/00103, RETICs RIRAAF RD12/0013/0001, RD12/0013/0003 and RD12/0013/0008, RETIC ARADYAL RD16/0006/0001, RD16/0006/0012 and RD16/0006/0021, Biobank Network RD09/0076/00112, and Biobank platform PT13/0010/0006) and by State Secretariat for Research, Development and Innovation of the Ministry of Economy and Competitiveness (grants cofunded by European Regional Development Fund (ERDF), “Una manera de hacer Europa”: MINECO SAF2012-36519, SAF2015-68590R, CTQ2013-41339P, and CTQ2016-75870P). Andalusian Regional Ministry of Economy and Knowledge (grants cofunded by European Regional Development Fund (ERDF), “Andalucía se mueve con Europa”: CTS-06603); Andalusian Regional Ministry Health (grants: PI-0699-2011, PI-0159-2013, PI-0179-2014, PI-0241-2016, and PI-0250-2016), Merck-Serono Research Grant from Fundación Salud 2000 and “Premio UNICAJA a la innovación en biomedicina y salud.” CM holds a “Nicolas Monardes” research contract by Andalusian Regional Ministry Health: C-0044-2012 SAS 2013. MIM holds a “Miguel Servet I” and GB holds a “Rio Hortega,” both research contracts by Institute of Health “Carlos III” of the Ministry of Economy and Competitiveness (grants cofunded by European Social Fund (ESF)): CP15/00103 and CM16/00067. TDF hold a “Ramon y Cajal” research contract from Ministry of Economy and Competitiveness (RYC-2013-13138).
Published: 2018

245. Crowd counting system by facial recognition using Histogram of Oriented Gradients, Completed Local Binary Pattern, Gray-Level Co-Occurrence Matrix and Unmanned Aerial Vehicle

Author: Robee Jasper B. Velasco, Ramon G. Garcia, Jessie R. Balbin, Karyl Denise G. Magpayo, Kaira Emi D. Fernandez, and Nicolo Paolo G. Golosinda
Subjects: Gray level, Co-occurrence matrix, Histogram of oriented gradients, Computer science, Local binary patterns, business.industry, Pattern recognition, Artificial intelligence, business, Facial recognition system, Crowd counting
Published: 2018

246. Prehospital Resuscitation Performed on Hypotensive Trauma Patients in Afghanistan: The Prehospital Trauma Registry Experience

Author: Steven G. Schauer, Andrew D Fisher, Jessie Renee D. Fernandez, Brian P Shreve, Cord W. Cunningham, Jason F Naylor, Michael D April, and Vikhyat S. Bebarta
Subjects: Adult, Male, medicine.medical_specialty, Resuscitation, Emergency Medical Services, 0211 other engineering and technologies, Psychological intervention, Hemorrhage, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, 030212 general & internal medicine, Registries, Hetastarch, 021110 strategic, defence & security studies, Chi-Square Distribution, Afghan Campaign 2001, business.industry, Public Health, Environmental and Occupational Health, Afghanistan, General Medicine, Fluid warmer, Blood pressure, Emergency medicine, Cohort, Fluid Therapy, Wounds and Injuries, Female, Hypotension, business, Packed red blood cells, Chi-squared distribution
Abstract: INTRODUCTION Hemorrhage is the leading cause of potentially preventable death on the battlefield. Hypotension in the setting of trauma portends a higher rate of mortality. We describe the interventions for trauma-related hypotension performed in the prehospital combat setting in accordance with Tactical Combat Casualty Care (TCCC) guidelines. MATERIALS AND METHODS We searched the Prehospital Trauma Registry for casualties from January 2013 to September 2014. Within that group, we searched for all casualties with documented hypotension by either measured systolic blood pressure ≤90 mmHg or a weak or absent radial pulse documented by the prehospital provider. We used descriptive statistics to analyze the interventions performed in our study sample. RESULTS Of the 705 casualties available for query, 134 (19.0%) casualties with documented hypotension met inclusion criteria. Most casualties with hypotension had an alert mental status (70.1%), had a medical officer in their chain of care (59.0%), were Afghan (64.2%), and evacuated on an urgent status (78.4%). Explosives were the most frequent mechanism of injury (50.7%). There were 42 fluid administrations documented on 33 (24.6%) casualties. The most common fluid administered was normal saline (52.4%) followed by hetastarch solution (33.3%). There was one documented use of a fluid warmer in this cohort. One subject received four units of packed red blood cells. No other casualties had documented blood product administration. There were no documented administrations of PlasmaLyte. There were four casualties that received lactated Ringer's. CONCLUSION Most casualties with documented hypotension after trauma in the Prehospital Trauma Registry did not receive prehospital blood or fluid intervention. Of the interventions performed, most did not match with contemporary TCCC guidelines.
Published: 2018

247. Functional studies about the Tim-3/Gal-9 axis in drug-Induced maculopapular exanthema

Author: Tahia D Fernandez, Cristobalina Mayorga, and Rubén Fernández Santamaría
Published: 2018

248. 'Pandora'

Author: Carlo M. Palicpic, Jayson J. Cruz, Ronina C. Tayuan, Russell D. Fernandez, and Dominick L. Uyehara
Subjects: Dictionary attack, Alphanumeric, Computer science, business.industry, Encryption software, Advanced Encryption Standard, Hash function, Computer security, computer.software_genre, Encryption, Key (cryptography), business, computer, Graphical user interface
Abstract: Privacy and security have never been more important. The need for these things are on the rise considering that more and more reports of digital theft and massive unsolicited government surveillance are surfacing. The project, Pandora, is a solution created by the proponents to provide an encryption scheme that is a combination of the new and the old. Pandora is an integration of AES-256 and modified ciphers. You can use it to encrypt and decrypt files, just like typical AES encryption, but with the added complexity offered by the ciphers. The system is primarily developed using Java programming language using NetBeans IDE. The program will ask for a file input which will then be processed through multi-level encryption. Running parallel with this, the system will ask for a key which will be used for decryption. The final output will be a ".pxt file". All of these are presented to a user with a graphical user interface (GUI). Added security elements were also implemented to ensure the confidentiality of the files. The key is required to be between eight to thirty-two mixed alphanumeric characters which will then be processed through separate hashing algorithm. This scheme ensures that it would take at least 3 to 3.914349685892112e+43 years to brute force or to perform dictionary attack on the key.
Published: 2018

249. Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests

Author: Amene Tesfaye, Yolanda Vida, Noemi Molina, Angela Martin-Serrano, Ezequiel Perez-Inestrosa, María José Torres, Maria I. Montañez, Cristobalina Mayorga, Francisco Najera, Tahia D. Fernandez, [Molina,N, Najera,F, Vida,Y, Perez-Inestrosa,E] Departamento de Química Orgánica, Universidad de Málaga—IBIMA, Málaga, Spain. [Molina,N, Martin-Serrano,A, Fernandez,TD, Tesfaye,A, Torres,MJ, Mayorga,C, Montañez,MI, Perez-Inestrosa,E] Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Parque Tecnológico de Andalucía, Málaga, Spain. [Martin-Serrano,A, Fernandez,TD, Tesfaye,A, Montañez,MI] Research Laboratory, IBIMA—Regional University Hospital of Málaga—UMA, Málaga, Spain. [Torres,MJ, Mayorga,C] Allergy Unit, IBIMA—Regional University Hospital of Málaga—UMA,Málaga, Spain, The present study has been supported by State Secretariat for Research, Development and Innovation of the Ministry of Economy and Competitiveness (grants cofunded by European Regional Development Fund (ERDF)): MINECO CTQ2016-75870P, by Institute of Health 'Carlos III' (ISCIII) of MINECO (grants cofunded by ERDF): PI12/02529, PI15/01206, CP15/00103, PI17/01237, RETICs RIRAAF RD12/0013/0001 and 0003 and RETIC ARADYAL RD16/0006/0001 and 0012, by Andalusian Regional Ministry of Economy and Knowledge (grants cofunded by ERDF): CTS-06603, and by Andalusian Regional Ministry Health (grants: PI-0699-2011, PI-0179-2014, PI-0241-2016 and PI-0250-2016), and 'Premio UNICAJA a la innovación en biomedicina y salud'. NM holds a FPU grant of MECD (FPU15/00641). TDF hold a 'Ramon y Cajal' research contract from MINECO (RYC-2013-13138). AT has received funding from the European Union’s H2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713721. CM holds a ‘Nicolas Monardes’ research contract by Andalusian Regional Ministry Health: C-0044-2012 SAS 2013. MIM holds a 'Miguel Servet I' (CP15/00103) contract by ISCIII of MINECO (grants cofunded by European Social Fund (ESF)). Partially supported by Open Access Funds from 'Universidad de Málaga'.
Subjects: 0301 basic medicine, Models, Molecular, Magnetic Resonance Spectroscopy, Pharmaceutical Science, Basophil, PAMAM, Immunoglobulin E, Epitope, Analytical Chemistry, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassay [Medical Subject Headings], Epitopes, Drug Discovery, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular [Medical Subject Headings], dendrimeric antigens, Immunoassay, Prueba de desgranulación de los Basófilos, biology, medicine.diagnostic_test, Chemistry, penicillin, drug allergy, basophil activation tests, Penicilinas, Chemicals and Drugs::Biological Factors::Antigens::Epitopes [Medical Subject Headings], 3. Good health, Basophils, Diseases::Chemically-Induced Disorders::Drug-Related Side Effects and Adverse Reactions::Drug Hypersensitivity [Medical Subject Headings], medicine.anatomical_structure, Chemistry (miscellaneous), Molecular Medicine, Hipersensibilidad a las drogas, Cell activation, Dendrimers, Drug allergy, Penicillins, Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Structure-Activity Relationship [Medical Subject Headings], Article, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance Spectroscopy [Medical Subject Headings], Drug Hypersensitivity, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, Antigen, lcsh:Organic chemistry, medicine, Humans, Physical and Theoretical Chemistry, Organic Chemistry, Allergens, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins [Medical Subject Headings], medicine.disease, Basophil activation, 030104 developmental biology, Immunology, biology.protein, Chemicals and Drugs::Biological Factors::Antigens::Allergens [Medical Subject Headings], Chemicals and Drugs::Macromolecular Substances::Polymers::Dendrimers [Medical Subject Headings], Anatomy::Cells::Myeloid Cells::Granulocytes::Basophils [Medical Subject Headings]
Abstract: Dendrimeric Antigens (DeAns) consist of dendrimers decorated with multiple units of drug antigenic determinants. These conjugates have been shown to be a powerful tool for diagnosing penicillin allergy using in vitro immunoassays, in which they are recognized by specific IgE from allergic patients. Here we propose a new diagnostic approach using DeAns in cellular tests, in which recognition occurs through IgE bound to the basophil surface. Both IgE molecular recognition and subsequent cell activation may be influenced by the tridimensional architecture and size of the immunogens. Structural features of benzylpenicilloyl-DeAn and amoxicilloyl-DeAn (G2 and G4 PAMAM) were studied by diffusion Nuclear Magnetic Resonance (NMR) experiments and are discussed in relation to molecular dynamics simulation (MDS) observations. IgE recognition was clinically evaluated using the basophil activation test (BAT) for allergic patients and tolerant subjects. Diffusion NMR experiments, MDS and cellular studies provide evidence that the size of the DeAn, its antigen composition and tridimensional distribution play key roles in IgE-antigen recognition at the effector cell surface. These results indicate that the fourth generation DeAns induce a higher level of basophil activation in allergic patients. This approach can be considered as a potential complementary diagnostic method for evaluating penicillin allergy. Yes
Published: 2018

250. Population study of Galactic supernova remnants at very high γ-ray energies with H.E.S.S

Author: Christo Venter, H. Iwasaki, Gilles Maurin, Q. Piel, J. F. Glicenstein, J. Becker Tjus, A. Zech, M. Büchele, Julien Lefaucheur, Nachiketa Chakraborty, R. Liu, C. Mariaud, L. O'c. Drury, A.M. Taylor, C. Perennes, T. Garrigoux, Riaan Steenkamp, Ruben Lopez-Coto, Pierre Brun, M. Lemoine-Goumard, A. Wörnlein, P.-O. Petrucci, H. Ndiyavala, G. Lamanna, S. J. Fegan, A. Djannati-Ataï, N. W. Pekeur, P. Wagner, Alison Mitchell, Dieter Horns, Jean-Pierre Ernenwein, Zorawar Wadiasingh, B. Condon, I. Shilon, M. Seglar-Arroyo, Jan Conrad, Marco Padovani, Clemens Hoischen, A. A. Zdziarski, Frank M. Rieger, Johannes Veh, D. Gottschall, D. A. Sanchez, J. Hawkes, Anne Lemiere, Gavin Rowell, M. Bryan, R. C. G. Chaves, E. O. Angüner, Reinhard Schlickeiser, D. Zaborov, D. Jankowsky, Monica Barnard, A. S. Seyffert, Axel Donath, R. de los Reyes, A. W. Chen, M. Tluczykont, D. Fernandez, V. Poireau, Cameron B Rulten, C. Romoli, K. Morå, F. Gaté, Felix Spanier, I. Jung-Richardt, Manuel Meyer, H. Abdalla, Christian Stegmann, I. Oya, Stefan Wagner, Yasunobu Uchiyama, D. Wouters, M. A. Kastendieck, G. Vasileiadis, Nu. Komin, Jim Hinton, Y. A. Gallant, Fabian Schüssler, Matteo Cerruti, Stefan Ohm, Markus Holler, Felix Jankowsky, J. Decock, M. Mayer, S. Pita, Dmitry Khangulyan, Dorit Glawion, E. Moulin, Tomasz Bulik, S. Nakashima, J. Zorn, Robert Wagner, Thomas Lohse, L. Mohrmann, Felix Aharonian, L. Dirson, C. Farnier, Ramin Marx, E. Leser, M. Panter, U. Katz, Stefano Gabici, J. Dyks, C. van Rensburg, Werner Hofmann, G. Emery, Samar Safi-Harb, Thomas Vuillaume, B. Khélifi, S. Saito, Justine Devin, M. Lorentz, S. Bonnefoy, Constantin Steppa, M. Füßling, S. Eschbach, Jacek Niemiec, G. Hermann, Regis Terrier, Stefan Klepser, A. Balzer, Heinrich J. Völk, M. Mohamed, Olaf Reimer, P. P. Krüger, F. Voisin, D. Klochkov, Alexandre Marcowith, D.A. Prokhorov, M. Renaud, F. Zefi, D. Kerszberg, Rachel Simoni, Helen Poon, M. Jingo, R. D. Parsons, D. J. van der Walt, L. Oakes, J. Bolmont, I. Sushch, A. Ivascenko, R. Blackwell, S. Colafrancesco, Michael Backes, H. Prokoph, Masanori Arakawa, Gianluca Giavitto, V. Marandon, K. Dutson, Thomas Murach, Joachim Hahn, J. Lau, M. Settimo, Andreas Quirrenbach, Sami Caroff, Włodek Kluźniak, M. Capasso, S. Krakau, V. Sahakian, P. Bordas, Michael Zacharias, F. Niederwanger, J. P. Lees, H. Odaka, Tim Holch, S. Raab, A. Abramowski, G. Heinzelmann, N. Maxted, Krzysztof Katarzynski, A. Jacholkowska, Naomi Tsuji, Tanya Edwards, K. Kosack, Konrad Bernlöhr, Jacco Vink, Catherine Boisson, L. Tibaldo, D. Berge, Christoph Deil, Sabrina Casanova, Gerard Fontaine, G. Pelletier, B. Peyaud, Ullrich Schwanke, G. Pühlhofer, Johan Bregeon, J.-P. Tavernet, Kleopas Shiningayamwe, R. J. White, A. Reimer, A. Viana, Domenico Tiziani, D. Malyshev, Łukasz Stawarz, S. Bernhard, B. van Soelen, Michal Ostrowski, B. Rudak, J.-P. Lenain, F. Ait Benkhali, P. T. O'Brien, M. V. Fernandes, Manami Sasaki, S. Schwemmer, Andrea Santangelo, Gilles Henri, C. van Eldik, Stefan Funk, Alicja Wierzcholska, Marek Jamrozy, Helene Sol, B. Giebels, R. J. Tuffs, L. Jouvin, Iryna Lypova, Yvonne Becherini, K. Egberts, J. Chevalier, R. Rauth, Thomas Tavernier, N. Shafi, Natalia Żywucka, M. de Naurois, Ruizhi Yang, Tadayuki Takahashi, A. Schulz, Isak Delberth Davids, A. Fiasson, Roberta Zanin, P. Willmann, C. Trichard, P. J. Meintjes, A. Ziegler, H. Laffon, M. Arrieta, P. deWilt, J. King, Marion Spir-Jacob, Maria Haupt, Michelle Tsirou, L. Rinchiuso, Rafal Moderski, A. Carosi, Francois Brun, P. Vincent, M.-H. Grondin, Markus Böttcher, M. Katsuragawa, Pierre-Henri Aubert, M. Kraus, Michael Punch, Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), Institut de Planétologie et d'Astrophysique de Grenoble ( IPAG ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), HESS, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), and API Other Research (FNWI)
Subjects: electron, Milky Way, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, Infrarot-Astrophysik - Abteilung Hofmann, Cosmic ray, magnetic field, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Compact star, 7. Clean energy, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, supernova, ddc:530, luminosity, flux: upper limit, cosmic radiation: acceleration, 010303 astronomy & astrophysics, HESS - Abteilung Hofmann, Astrophysics::Galaxy Astrophysics, ISM: supernova remnants, Astroparticle physics, Physics, radio wave, density, energy: high, cosmic radiation: spectrum, 010308 nuclear & particles physics, supernova remnants [ISM], Molecular cloud, shell model, Institut für Physik und Astronomie, Astronomy and Astrophysics, gamma rays: general, Galactic plane, Supernova, gamma ray: VHE, Space and Planetary Science, cosmic radiation: galaxy, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], general [gamma rays]
Abstract: 著者人数: H.E.S.S. Collaboration 253名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 桂川, 美穂; 中島, 真也; 小高, 裕和; 高橋, 忠幸), Number of authors: H.E.S.S. Collaboration 253 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Katsuragawa, Miho; Nakashima, Shinya; Odaka, Hirokazu; Takahashi, Tadayuki), Accepted: 2018-02-08, 資料番号: SA1170368000
Published: 2018

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