AB0255 RISK OF FRAGILITY FRACTURE IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS

Background:Rheumatoid Arthritis (RA) is associated with low bone density and hight risk fracture compared to general population.Objectives:The aim of this study is to assess the effect of some variables on fragility fractures in patients with RA.Methods:We perform an observational study in a cohort of patients diagnosed of RA according to 1987 and 2010 ACR criteria, to determine the frequency of osteoporotic fractures and associated clinical and densitometric variables. All patients diagnosed of RA were invited to participate in the study between 2013 and 2019, and to perform BMD DXA (GELunarProdigy®). SPSS25 was used to compare variables between patients with fracture and without fracture.Results:376 patients with RA were included (78,7% women), mean age 63,3 (±13,2) years old and a mean of evolution of the RA of 118,7(±96,7) months at the moment the BMD was performed. We found bone fracture in 47 (12,6%) patients. Fractures were associated to female gender (OR: 2,93 (1,08-7,93); p=0,02), lower height and weight (pTable 1 shows the characteristics and differences between patients with and without fragility fractures. Women presented high risk of osteoporosis in lumbar spine [OR=3,89(1,46-10,37); p=0,002] than men, but any differences between gender were found in BMD of femoral neck. Of the fractured patients, BMD T-score was normal in 2 (4,3%), Table 1.CharacteristicsPatients with fractures (n=47)Patients without fractures (n=327)OR (IC 95%); p valueFemales43 (14,7%)250 (85,3%)2,9 (1,1-7,8); p=0,02Age67,7 (±10,6)62,7 (±11,6)P=0,005Height152,4 (±9,4)157,3 (±8,8)P=0,001Weight66,2 (±16)73,3 (±14,4)P=0,003Smokers8 (12,1%)58 (87,9%)0,9 (0,4-2,1) p=0,89RF (+)35 (12,2%)252 (87,8%)0,9 (0,4-1,7) p=0,66ACPA+30 (12,3%)213 (87,7%)1,3 (0,6-2,8) p=0,44Steroids36 (14,4%)214 (85,6%)1,7 (0,8-3,5) p=0,13Biologics treatment16 (16,2%)83 (83,8%)1,5 (0,8-2,9) p=0,22Bone mineral density (BMD) in lumbar spine34 (16,8)168 (83,2)2,6 (1,3-5,2) p=0,006BMD femoral neck CF43 (17,8)198 (82,2)9,0 (2,7-29,6) pBMD lumbar spine17 (26,6)47 (73,4)3,4 (1,7-6,7) pBMD femoral neck20 (29,4)48 (70,6)4,4 (2,3-8,5) pMajor osteoporotic risk (FRAX)37 (23,6)120 (76,4)7,4 (3,2-17,2) pHip fracture risk (FRAX)34 (24,5)105 (75,5)5,9 (2,8-12,5) pConclusion:Women with RA present higher risk of fracture than men. The most sensitive indicator for fracture risk seems to be MBD in femoral neck.Disclosure of Interests:None declared