Search

Your search keyword '"CHATTOPADHYAY, DIPANKAR"' showing total 596 results
Start Over Author "CHATTOPADHYAY, DIPANKAR"
596 results on '"CHATTOPADHYAY, DIPANKAR"'

204. An ex situ approach to fabricating nanosilica reinforced polyacrylamide grafted guar gum nanocomposites as an efficient biomaterial for transdermal drug delivery application

Author

Dutta, Koushik, primary, Das, Beauty, additional, Mondal, Dipankar, additional, Adhikari, Arpita, additional, Rana, Dipak, additional, Kumar Chattopadhyay, Atis, additional, Banerjee, Rajdeb, additional, Mishra, Roshnara, additional, and Chattopadhyay, Dipankar, additional

Published
2017
Full Text
View/download PDF

206. The gamut of perspectives, challenges, and recent trends for in situhydrogels: a smart ophthalmic drug delivery vehicle

Author

Das, Beauty, Chattopadhyay, Dipankar, and Rana, Dipak

Abstract

Polymers have a major role in the controlled delivery of pharmaceutical compounds to a targeted portion of the body. In this quest, a high priority research area is the targeted delivery of ophthalmic drugs to the interior regions of the eyes. Due to their complex anatomical/biochemical nature. This necessitates an advanced drug delivery cargo that could administer a therapeutic agent to the targeted location by evading various obstacles. The ongoing focus is to design an ophthalmic formulation by coupling it with a smart in situforming polymeric hydrogel. These smart macromolecules have an array of unique theranostic properties and can utilize the in vivobiological parameters as a stimulus to change their macromolecular state from liquid to gel. The fast gelling hydrogel improves the corneal contact time, facilitates sustained drug release, resists the burst-out effect, and assists drug permeability to anterior regions. This review summarizes the rationale, scientific objectives, properties, and classification of the biologically important in situhydrogels in the niche of ophthalmic drug delivery. The current trends and prospectives of the array of stimulus-responsive polymers, copolymers, and nanomaterials are discussed broadly. The crucial biointerfacial attributes with pros and cons are reviewed by investigating the effect of the nature of polymers as well as the ratio/percentage of additives and copolymers that influence the overall performance.

Published
2020
Full Text
View/download PDF

207. The rubber–filler interaction and reinforcement in styrene butadiene rubber/devulcanize natural rubber composites with silica–graphene oxide.

Author

Mondal, Dipankar, Ghorai, Soumyajit, Rana, Dipak, De, Debapriya, and Chattopadhyay, Dipankar

Subjects
REINFORCEMENT of elastomers, RUBBER fillers, POLYBUTADIENE, VULCANIZATION, GRAPHENE oxide, COMPOSITE materials
Abstract

Ethoxy functionalized devulcanize natural rubber (DeVulcNR) is used as compatibilizer for silica/graphene oxide (SiO2@GO) hybrid fillers in the styrene butadiene rubber (SBR) to fabricate SBR composites. The dispersion behavior of SiO2@GO hybrid filler was investigated through scanning electron microscopy (SEM) analysis of the tensile fracture surface along with the broken rubber surface developed by plunging into liquid nitrogen. The rubber–filler interfacial interactions were evaluated through the measurement of equilibrium swelling experiment, fraction of immobilized polymer chain by DSC study, FTIR analysis, and molecular dynamics simulation. The results reveal that in the presence of DeVulcNR, the rubber–filler interaction is enhanced compared with that of the control formulations containing only SBR. SiO2@GO hybrid‐filler shows synergistic effect on the mechanical properties of the composites in the presence of DeVulcNR. The improved mechanical properties of the SiO2@GO hybrid filler rubber composites may be due to chemical interaction among the functional groups of SiO2 and GO with the DeVulcNR. Further, XRD study indicates that there is no significant layer‐by‐layer restack of GO in the SBR/DeVulcNR composites. The higher storage modulus and lower tan δ of the SiO2@GO hybrid filler rubber composites show superior interfacial interaction between rubber and filler compared with that of the control formulations. POLYM. COMPOS., 40:E1559–E1572, 2019. © 2018 Society of Plastics Engineers [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

209. Enhanced Triethylamine Detection at Room Temperature Using a Layered MoS2Nanosheet-Coated PPy Nanorod: A Comprehensive Study

Author

Adhikari, Monalisa, Saha, Debdulal, Chattopadhyay, Dipankar, and Pal, Mrinal

Abstract

The rapid and reliable detection of triethylamine (TEA), a toxic, explosive, volatile organic compound at room temperature, is highly significant for food safety, environmental, and human health monitoring. This manuscript reports a layered molybdenum disulfide (MoS2) nanosheet-coated polypyrrole (PPy) nanorod-based heterostructure sensor (MsPy) which offers superior sensing properties toward TEA at room temperature (25 °C). Herein, different MsPy nanocomposites were synthesized, followed by a controlled sulfidation reaction through dissolution, diffusion, and regrowth mechanisms. Optimizing the ratio of the precursor of molybdenum trioxide (MoO3/PPy) is crucial for achieving effective deposition of a layered MoS2nanosheet on the PPy surface. The as-prepared MoS2nanosheet-coated PPy sensor (MsPy_40) enables one to selectively detect trace TEA vapor at 25 °C with a detection lower limit of 0.5 ppm. The MsPy_40 sensor exhibits 17 times higher response than the pristine MoS2nanosheet to 50 ppm TEA, with rapid response (∼3.9 s) and recovery (∼19.6 s), along with better stability, good selectivity, and remarkable repeatability. The significantly enhanced sensing performance is attributed to the unique surface morphology of the layered MoS2nanosheet-coated PPy nanorod and the formation of a p–n heterojunction between PPy and MoS2.

Published
2024
Full Text
View/download PDF

210. Tailoring the Efficacy of Multifunctional Biopolymeric Graphene Oxide Quantum Dot-Based Nanomaterial as Nanocargo in Cancer Therapeutic Application

Author

De, Sriparna, Patra, Kartick, Ghosh, Debatri, Dutta, Koushik, Dey, Aditi, Sarkar, Gunjan, Maiti, Jyotirmay, Basu, Arijita, Rana, Dipak, and Chattopadhyay, Dipankar

Abstract

Nanotechnology has acquired an immense recognition in cancer theranostics. Considerable progress has been made in the development of targeted drug delivery system for potent delivery of anticancer drugs to tumor-specific sites. Recently, multifunctional nanomaterials have been explored and used as nanovehicles to carry drug molecules with enhanced therapeutic efficacy. In this present work, graphene oxide quantum dot (GOQD) was conjugated with folic acid functionalized chitosan (FA-CH) to develop a nanocargo (FA-CH-GOQD) for drug delivery in cancer therapy. The synthesized nanomaterials were characterized using Fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy, scanning electron microscopy, transmission electron microscopy, and dynamic light scattering. Photoluminescence spectroscopy was also employed to characterize the formation of GOQD. To validate the efficacy of FA-CH-GOQD as nanocarriers, doxorubicin (DOX) drug was chosen for encapsulation. The in vitro release pattern of DOX was examined in various pH ranges. The drug release rate in a tumor cell microenvironment at pH 5.5 was found higher than that under a physiological range of pH 6.5 and 7.4. An MTT assay was performed to understand the cytotoxic behavior of GOQD and FA-CH-GOQD/DOX. Cytomorphological micrographs of the A549 cell exhibited the various morphological arrangements subject to apoptosis of the cell. Cellular uptake studies manifested that FA-CH-GOQD could specifically transport DOX within a cancerous cell. Further anticancer efficacy of this nanomaterial was corroborated in a breast cancer cell line and demonstrated through 4′,6-diamidino-2-phenylindole dihydrochloride staining micrographs.

Published
2024
Full Text
View/download PDF

218. Self-assembly, doxorubicin-loading and antibacterial activity of well-defined ABA-type amphiphilic poly(N-vinylpyrrolidone)-b-poly(d,l-lactide)-b-poly(N-vinyl pyrrolidone) triblock copolymers

Author

Ramesh, K., primary, Gundampati, Ravi Kumar, additional, Singh, Shikha, additional, Mitra, Kheyanath, additional, Shukla, Ankita, additional, Jagannadham, Medicherla V., additional, Chattopadhyay, Dipankar, additional, Misra, Nira, additional, and Ray, Biswajit, additional

Published
2016
Full Text
View/download PDF

219. Green one step morphosynthesis of silver nanoparticles and their antibacterial and anticancerous activities

Author

Maity, Dipanwita, primary, Pattanayak, Sutanuka, additional, Mollick, Md. Masud Rahaman, additional, Rana, Dipak, additional, Mondal, Dibyendu, additional, Bhowmick, Biplab, additional, Dash, Sandeep Kumar, additional, Chattopadhyay, Sourav, additional, Das, Balaram, additional, Roy, Somenath, additional, Chakraborty, Mukut, additional, and Chattopadhyay, Dipankar, additional

Published
2016
Full Text
View/download PDF

228. Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

Author

Vishwakarma, Niraj Kumar, primary, Patel, Vijay Kumar, additional, Hira, Sumit Kumar, additional, Ramesh, K., additional, Srivastava, Prateek, additional, Mitra, Kheyanath, additional, Singh, Shikha, additional, Chattopadhyay, Dipankar, additional, Maiti, Pralay, additional, Misra, Nira, additional, Manna, Partha Pratim, additional, and Ray, Biswajit, additional

Published
2015
Full Text
View/download PDF

236. Anticancer (in vitro) and antimicrobial effect of gold nanoparticles synthesized using Abelmoschus esculentus (L.) pulp extract via a green route

Author

Rahaman Mollick, Md. Masud, primary, Bhowmick, Biplab, additional, Mondal, Dibyendu, additional, Maity, Dipanwita, additional, Rana, Dipak, additional, Dash, Sandeep Kumar, additional, Chattopadhyay, Sourav, additional, Roy, Somenath, additional, Sarkar, Joy, additional, Acharya, Krishnendu, additional, Chakraborty, Mukut, additional, and Chattopadhyay, Dipankar, additional

Published
2014
Full Text
View/download PDF

238. Assessment of morphology and property of graphene oxide-hydroxypropylmethylcellulose nanocomposite films

Author

Ghosh, Tapas Kumar, primary, Gope, Shirshendu, additional, Mondal, Dibyendu, additional, Bhowmik, Biplab, additional, Mollick, Md. Masud Rahaman, additional, Maity, Dipanwita, additional, Roy, Indranil, additional, Sarkar, Gunjan, additional, Sadhukhan, Sourav, additional, Rana, Dipak, additional, Chakraborty, Mukut, additional, and Chattopadhyay, Dipankar, additional

Published
2014
Full Text
View/download PDF

239. Comparative evaluation of physico-chemical characteristics of biopolyesters P(3HB) and P(3HB-co-3HV) produced by endophytic Bacillus cereusRCL 02

Author

Das, Rituparna, Saha, Nayan, Pal, Arundhati, Chattopadhyay, Dipankar, and Paul, Amal

Abstract

Bacteria endogenously residing within the plant tissues have attracted significant attention for production of biopolyester, polyhydroxyalkanoates (PHAs). Bacillus cereusRCL 02 (MCC 3436), a leaf endophyte of oleaginous plant Ricinus communisL. accumulates 81% poly(3-hydroxybutyrate) [P(3HB)] of its cell dry biomass when grown in mineral salts (MS) medium. The copolymer production efficiency of B. cereusRCL 02 was evaluated in valeric acid supplemented MS medium under biphasic cultivation condition. The copolymer so produced has been compared with the P(3HB) isolated from RCL 02 in terms of thermal, mechanical and chemical properties. Valeric acid supplementation as co-substrate in the medium has led to the production of copolymer of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) [P(3HB-co-3HV)] with 14.6 mol% 3HV. The identity of the polymers has been confirmed by X-ray diffraction (XRD) analysis, Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopic studies. Thermogravimetric analysis (TGA) revealed that P(3HB) and P(3HB-co-3HV) films degraded at 278.66°C and 273.49°C, respectively. The P(3HB-co-3HV) showed lower melting temperature (165.03°C) compared to P (3HB) (170.74°C) according to differential scanning calorimetry (DSC). Incorporation of 3HV monomers decreased the tensile strength (21.52 MPa), tensile modulus (0.93 GPa), storage modulus (E′) (0.99 GPa) and increased % elongation at break (12.2%) of the copolyester. However, P(3HB) showed better barrier properties with lower water vapor transmission rate (WVTR) of 0.55 g-mil/100 in2/24 h. These findings emphasized exploration of endophytic bacterial strain (RCL 02) to produce biodegradable polyesters which might have significant potential for industrial application.

Published
2018
Full Text
View/download PDF

241. Ultrahigh energy density solid state supercapacitor based on metal halide perovskite nanocrystal electrodes: Real-life applications

Author

Ali, Mir Sahanur, Layek, Rashbihari, Ali, Mir Sahidul, Tudu, Surajit, Dutta, Koushik, Gangopadhyay, Bhuman, Karmakar, Devdas, Mallik, Amit, Panda, Subrata, Maiti, Anupam, Ghoshal, Debajyoti, Karmakar, Srikanta, Kumbhakar, Pathik, and Chattopadhyay, Dipankar

Abstract

Inorganic lead halide perovskite nanocrystals have now become an emerging material for modern nanodevice applications. But, the huge toxicity of lead to the ecosystem has limited its applications in modern technology. In this view, a large organic cation-based metal halide perovskite may be considered the most efficient supercapacitor electrode material. Here, a new type and high molecular organic cations based low-dimensional metal halide perovskite (LDMHP) nanocrystals (NCs) are synthesized by a chemical process and their performances as supercapacitor electrode is tested. An excellent charge storage capacity and especially the Tin (Sn)-based perovskite NCs showed a very high specific capacitance and energy density of ~1536 Fg−1and ~213 Whkg−1at a current density of 2.0 Ag−1, respectively. The calculated variable parameter (b) value from cyclic voltammetry showed that the total capacity of the Sn-based perovskite NCs electrode is controlled by capacitor-like behaviour. The Sn NCs also found to have a very high DC dielectric constant at room temperature, possibly responsible for their superior supercapacitor performance. A solid-state supercapacitor based on synthesized NCs was used for real-life applications of supplying sufficient power to light emitting diodes (LEDs) for a long time.

Published
2023
Full Text
View/download PDF

242. Ameliorative effects of clindamycin - nanoceria conjugate: A ROS responsive smart drug delivery system for diabetic wound healing study.

Author

Saha, Kasturi, Ghosh, Adrija, Bhattacharya, Tuhin, Ghosh, Shatabdi, Dey, Sanjit, and Chattopadhyay, Dipankar

Subjects
TARGETED drug delivery, DRUG delivery systems, WOUND healing, DIABETIC foot, CLINDAMYCIN, PLATELET-rich plasma, FOURIER transform infrared spectroscopy, POLYMERSOMES
Abstract

Increased incidence of antibiotic-resistant species calls for development of new types of nano-medicine that can be used for healing of bacteria-caused wounds, such as diabetic foot ulcer. As diabetic patients have inefficient defense mechanism against reactive oxygen species (ROS) produced in our body as a by-product of oxygen reduction, the process of wound healing takes longer epithelialisation period. Ceria nanoparticles (CNPs) are well-known for their antibacterial and ROS-scavenging nature. Yet till now no significant effort has been made to conjugate ceria nanoparticles with drugs to treat diabetic wounds. In this experiment, CNPs were synthesized in-house and clindamycin hydrochloride was loaded onto it by physical adsorption method for reactive oxygen species responsive drug delivery. Various physico-chemical characterisations such as Transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, Energy dispersive X-ray, Thermogravimetric study etc. were performed to affirm the formation of both nanoceria along with drug encapsulated nanoceria. Both of these as-prepared formulations inhibited the growth of Gram-positive as well as Gram-negative bacteria confirmed by Disk diffusion study; exhibiting their antibacterial effect. In-vitro drug release study was carried out in physiological environment both in absence and presence of hydrogen peroxide solution to test the reactive ROS-responsiveness of the drug loaded nanocomposites. It also exhibited faster wound healing in diabetes-induced rats. Therefore, it could successfully lower the amount of serum glucose level, inflammation cytokines, hepatotoxic and oxidative stress markers in diabetic rats as confirmed by various ex vivo tests conducted. Thus, drug loaded ceria nanoparticles have the potential to heal diabetic wounds successfully and can be considered to be useful for the fabrication of appropriate medicated suppositories beneficial for diabetic foot ulcer treatment in future. [Display omitted] • Clindamycin hydrochloride was loaded onto nanoceria (CLIN@CNP) for diabetic wound healing study. • Successful drug loading onto nanoparticles with maximum loading of ≈ 22.5%, have been confirmed by TGA and UV spectral study. • Both neat drug and CLIN@CNP impede growth of Gram-positive besides Gram-negative bacteria signifying antibacterial activity. • In-vitro drug release data validated that CLIN@CNP exhibited ROS-responsive drug delivery for diabetic wound treatment. • Ex-vivo studies also confirmed establishment of nanoceria based futuristic model for diabetic treatment successfully. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

243. Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407

Author

Bhowmik, Manas, primary, Kumari, Puja, additional, Sarkar, Gunjan, additional, Bain, Mrinal Kanti, additional, Bhowmick, Biplab, additional, Mollick, Md. Masud Rahaman, additional, Mondal, Dibyendu, additional, Maity, Dipanwita, additional, Rana, Dipak, additional, Bhattacharjee, Debashis, additional, and Chattopadhyay, Dipankar, additional

Published
2013
Full Text
View/download PDF

249. Self-assembly of Novel Poly( d,l-Lactide- co-Glycolide)- b-Poly( N-Vinylpyrrolidone) (PLGA- b-PNVP) Amphiphilic Diblock Copolymers.

Author

Ramesh, K., Singh, Shikha, Mitra, Kheyanath, Chattopadhyay, Dipankar, Misra, Nira, and Ray, Biswajit

Subjects
DIBLOCK copolymers, BLOCK copolymers, CHEMICAL synthesis, POLYMERIZATION research, GEL permeation chromatography, COPOLYMER micelles, MICELLES synthesis
Abstract

Alkyne-terminated poly( d,l-lactide-co-glycolide) (PLGA) has been synthesized via ROP at room temperature. Amphiphilic PLGA- b-poly( N-vinylpyrrolidone) (PNVP) block copolymers have been synthesized via alkyne-azide click reaction of it with azide-terminated PNVPs prepared by RAFT polymerization of NVP using an azide-terminated RAFT agent. H NMR and gel permeation chromatography (GPC) confirmed the formation of block copolymers. Self-assembly of these block copolymers was confirmed by fluorescence study using pyrene as a probe and supported by H NMR, DLS and TEM studies. Hydrophobic drug doxorubicin was successfully encapsulated at the micellar core of PLGA- b-PNVP with drug-loading content (DLC) and drug-loading efficiency (DLE) of 10.8 and 43.2 %, respectively. Sustained drug release of these drug-loaded micelles was observed at both pH of 6.4 and 7.4. Faster drug release was observed at pH 6.4. Such PLGA- b-PNVP amphiphilic block copolymer may find extensive application in sustained drug delivery, specifically in antitumor drug delivery. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results