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Self-assembly of Novel Poly( d,l-Lactide- co-Glycolide)- b-Poly( N-Vinylpyrrolidone) (PLGA- b-PNVP) Amphiphilic Diblock Copolymers.
- Source :
- Colloid & Polymer Science; Feb2016, Vol. 294 Issue 2, p399-407, 9p
- Publication Year :
- 2016
-
Abstract
- Alkyne-terminated poly( d,l-lactide-co-glycolide) (PLGA) has been synthesized via ROP at room temperature. Amphiphilic PLGA- b-poly( N-vinylpyrrolidone) (PNVP) block copolymers have been synthesized via alkyne-azide click reaction of it with azide-terminated PNVPs prepared by RAFT polymerization of NVP using an azide-terminated RAFT agent. H NMR and gel permeation chromatography (GPC) confirmed the formation of block copolymers. Self-assembly of these block copolymers was confirmed by fluorescence study using pyrene as a probe and supported by H NMR, DLS and TEM studies. Hydrophobic drug doxorubicin was successfully encapsulated at the micellar core of PLGA- b-PNVP with drug-loading content (DLC) and drug-loading efficiency (DLE) of 10.8 and 43.2 %, respectively. Sustained drug release of these drug-loaded micelles was observed at both pH of 6.4 and 7.4. Faster drug release was observed at pH 6.4. Such PLGA- b-PNVP amphiphilic block copolymer may find extensive application in sustained drug delivery, specifically in antitumor drug delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0303402X
- Volume :
- 294
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Colloid & Polymer Science
- Publication Type :
- Academic Journal
- Accession number :
- 112693639
- Full Text :
- https://doi.org/10.1007/s00396-015-3795-1