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202. Sa1351 Voluntary and Controlled Weight Loss Can Reduce Symptoms and Allow a Lowering of Proton Pump Inhibitor Dosage in Patients With Gastroesophageal Reflux Disease. A Case-Control Study

Author

de Bortoli, Nicola, primary, Guidi, Giada, additional, Savarino, Edoardo, additional, Bertani, Lorenzo, additional, Franchi, Riccardo, additional, Martinucci, Irene, additional, Macchia, Lorenzo, additional, Ceccarelli, Linda, additional, Russo, Salvatore, additional, Furnari, Manuele, additional, Bellini, Massimo, additional, Savarino, Vincenzo, additional, and March, Santino, additional

Published
2014
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205. Effect of Lactobacillus paracaseiCNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: A pilot randomized clinical trial

Author

Cremon, Cesare, Guglielmetti, Simone, Gargari, Giorgio, Taverniti, Valentina, Castellazzi, Anna Maria, Valsecchi, Chiara, Tagliacarne, Carlotta, Fiore, Walter, Bellini, Massimo, Bertani, Lorenzo, Gambaccini, Dario, Cicala, Michele, Germanà, Bastianello, Vecchi, Maurizio, Pagano, Isabella, Barbaro, Maria Raffaella, Bellacosa, Lara, Stanghellini, Vincenzo, and Barbara, Giovanni

Abstract

Evidence suggests a role of intestinal microbiota-host interactions in the pathophysiology and symptoms of irritable bowel syndrome (IBS). The objective of this article is to assess the effects of Lactobacillus paracaseiCNCM I-1572 on clinical and gut microbiota-related factors in IBS. We conducted a multicenter, randomized, double-blind, cross-over, 18-week, placebo-controlled, pilot trial assessing the effect of Lactobacillus paracaseiCNCM I-1572 on symptoms, gut microbiota composition, fecal short chain fatty acid (SCFA), immunoglobulin A, and cytokines in IBS. The intestinal microbial ecosystem was characterized by 16S rRNA gene profiling. Forty IBS patients were enrolled from five Italian centers. Lactobacillus paracaseiCNCM I-1572 did not significantly improve IBS symptoms, including primary efficacy variables worst abdominal pain/discomfort and IBS degree of relief. Interestingly, Lactobacillus paracaseiCNCM I-1572 induced a significant reduction in genus Ruminococcus, dominated by taxa related to Ruminococcus bromiiand Ruminococcus callidus, a significant increase in the SCFAs acetate and butyrate, and a significant reduction in the pro-inflammatory cytokine interleukin-15. This pilot study shows that Lactobacillus paracaseiCNCM I-1572 is able to modulate gut microbiota structure/function and reduce immune activation in IBS. As no statistically significant effect on IBS-symptoms was found, further studies are necessary to determine the role of this probiotic in IBS. The study was registered at ClinicalTrials.gov registry under identifier NCT02371499.

Published
2018
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206. Duloxetine in panic disorder with somatic gastric pain

Author

Preve ,Matteo, Nisita,Cristiana, Bellini,Massimo, Dell'Osso,Liliana, Preve ,Matteo, Nisita,Cristiana, Bellini,Massimo, and Dell'Osso,Liliana

Abstract

Matteo Preve,1 Cristiana Nisita,1 Massimo Bellini,2 Liliana Dell'Osso1 1Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, 2Department of Gastroenterology, Gastrointestinal Unit, University of Pisa, Pisa, Italy Abstract: Panic disorder is the most common type of anxiety disorder, and its most common expression is panic attacks characterized with sudden attacks of anxiety with numerous symptoms, including palpitations, tachycardia, tachypnea, nausea, and vertigo: ie, cardiovascular, gastroenterologic, respiratory, and neuro-otologic symptoms. In clinical practice, panic disorder manifests with isolated gastroenteric or cardiovascular symptoms, requiring additional clinical visits after psychiatric intervention. The first-line treatment for anxiety disorders, and in particular for panic disorder, is the selective serotonin reuptake inhibitors. However, these drugs can have adverse effects, including sexual dysfunction, increased bodyweight, and abnormal bleeding, that may be problematic for some patients. Here we report the case of a 29-year-old Caucasian woman affected by panic disorder with agoraphobia who was referred to our clinic for recurrent gastroenteric panic symptoms. The patient reported improvement in her anxiety symptoms and panic attacks while on a selective serotonin reuptake inhibitor, but not in her gastric somatic problems, so the decision was taken to start her on duloxetine, a serotonin-norepinephrine reuptake inhibitor. After 6 months of treatment, the patient achieved complete remission of her gastric and panic-related symptoms, and was able to stop triple gastric therapy. Other authors have hypothesized and confirmed that duloxetine has greater initial noradrenergic effects than venlafaxine and is effective in patients with panic disorder. This case report underscores the possibility of tailoring therapeutic strategies for the gastroenteric expression of panic disorder. Keywords: anxiety disorder, panic attacks, palp

Published
2013

207. List of contributors

Author

Alterini, Giada, Bassotti, Gabrio, Bellini, Massimo, Blaga, Teodora Surdea, Blandizzi, Corrado, Brillanti, Stefano, Bronzini, Francesco, Colucci, Rocchina, Dumitrascu, Dan L., D’Mello, Charlotte, Fianchi, Francesca, Fornai, Matteo, Galli, Andrea, Grad, Simona, Kim, Yong-Ku, Laguna de la Vera, Anna-Lena, Maroni, Luca, Miele, Luca, Milani, Stefano, Pfeilschifter, Waltraud, Pop, Andrei V., Samanta, Sandip, Scalese, Giulia, Severi, Carola, Shawcross, Debbie L., Shin, Cheolmin, Stasi, Cristina, Svegliati Baroni, Gianluca, Swain, Mark G., Trebicka, Jonel, Usai Satta, Paolo, and Welsch, Christoph

Published
2021
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209. Optimal treatment of laryngopharyngeal reflux disease

Author

Martinucci, Irene, primary, de Bortoli, Nicola, additional, Savarino, Edoardo, additional, Nacci, Andrea, additional, Romeo, Salvatore Osvaldo, additional, Bellini, Massimo, additional, Savarino, Vincenzo, additional, Fattori, Bruno, additional, and Marchi, Santino, additional

Published
2013
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210. Ectopic pancreas in the gastric antrum: A spectrum of imaging findings

Author

Solito, Biagio, primary, Santi, Stefano, additional, Gambaccini, Dario, additional, Laino, Gabriella, additional, D’Imporzano, Simone, additional, Pallabazzer, Giovanni, additional, Bellini, Massimo, additional, Costa, Francesco, additional, Filice, Maria Elena, additional, Donati, Valentina, additional, Giusti, Patrizia, additional, and Marchi, Santino, additional

Published
2013
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211. 657 Use of a Non-Invasive Pepsin Diagnostic Test to Detect GERD: Correlation With MII-pH Evaluation in a Series of Suspected NERD Patients. A Pilot Study

Author

de Bortoli, Nicola, primary, Savarino, Edoardo, additional, Furnari, Manuele, additional, Martinucci, Irene, additional, Zentilin, Patrizia, additional, Bertani, Lorenzo, additional, Franchi, Riccardo, additional, Bellini, Massimo, additional, Savarino, Vincenzo, additional, and Marchi, Santino, additional

Published
2013
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212. Tu1808 The Evaluation of the Efficacy of Weight Loss in Controlling Symptoms in Patients With Gastroesophageal Symptoms

Author

de Bortoli, Nicola, primary, Guidi, Giada, additional, Savarino, Edoardo, additional, Furnari, Manuele, additional, Bertani, Lorenzo, additional, Franchi, Riccardo, additional, Russo, Salvatore, additional, Martinucci, Irene, additional, Gambaccini, Dario, additional, Urbano, Maria T., additional, Bellini, Massimo, additional, and Marchi, Santino, additional

Published
2013
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213. Su1190 Role of Contrast-Enhanced Ultrasonography (CEUS) in Assessment of Inflammatory Activity in Patients With Small Bowel Crohn's Disease

Author

Fluri, Giorgia Di, primary, Ceccarelli, Linda, additional, Ricchiuti, Angelo, additional, Mazzotta, Fabrizio, additional, Ussia, Valeria, additional, Bolognesi, Valeria, additional, Gambaccini, Dario, additional, Mumolo, Gloria M., additional, Bellini, Massimo, additional, Marchi, Santino, additional, and Costa, Francesco, additional

Published
2013
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214. Tu1783 Esophageal Impedance Basal Values in Patients With Pathophysiological Characteristcs of Functional Heartburn

Author

de Bortoli, Nicola, primary, Martinucci, Irene, additional, Savarino, Edoardo, additional, Furnari, Manuele, additional, Franchi, Riccardo, additional, Bertani, Lorenzo, additional, Russo, Salvatore, additional, Bellini, Massimo, additional, Urbano, Maria T., additional, Savarino, Vincenzo, additional, and Marchi, Santino, additional

Published
2013
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215. Mo2044 Irritable Bowel Syndrome, Serotonin Transporter 5HTTLPR Polymorphism and Psychopathological Traits: Dangerous Relations?

Author

Bellini, Massimo, primary, Gambaccini, Dario, additional, Urbano, Maria T., additional, Colucci, Rocchina, additional, Cortopassi, Sonia, additional, Salvadori, Stefano, additional, Costa, Francesco, additional, Mumolo, Gloria M., additional, Ricchiuti, Angelo, additional, de Bortoli, Nicola, additional, Ceccarelli, Linda, additional, Marchi, Santino, additional, and Blandizzi, Corrado, additional

Published
2013
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216. Nomenclature and diagnosis of gluten-related disorders: A position statement by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO).

Author

Elli, Luca, Villalta, Danilo, Roncoroni, Leda, Barisani, Donatella, Ferrero, Stefano, Pellegrini, Nicoletta, Bardella, Maria Teresa, Valiante, Flavio, Tomba, Carolina, Carroccio, Antonio, Bellini, Massimo, Soncini, Marco, Cannizzaro, Renato, and Leandro, Gioacchino

Abstract

Background “Gluten-related disorders” is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. Aim To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. Methods The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest. Each member was assigned a task and levels of evidence/recommendation have been proposed. Results The panel identified celiac disease, wheat allergy and non-celiac gluten sensitivity as the gluten-related disorders of gastroenterological interest. Celiac disease has an autoimmune nature, wheat allergy is IgE-mediated while the pathogenesis of non-celiac gluten sensitivity is still unknown as is the case of non-IgE mediated allergy. Diagnosis should start with the serological screening for celiac disease and wheat allergy. In case of normal values, the response to a gluten-free diet should be evaluated and a confirmatory blind food challenge carried out. Conclusions Gluten-related disorders are clinically heterogeneous. Patients should be carefully managed and specific protocols applied for a correct differential diagnosis in gastroenterological setting. [ABSTRACT FROM AUTHOR]

Published
2017
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217. Practice guidelines on the use of esophageal manometry – A GISMAD-SIGE-AIGO medical position statement.

Author

Savarino, Edoardo, de Bortoli, Nicola, Bellini, Massimo, Galeazzi, Francesca, Ribolsi, Mentore, Salvador, Renato, Savarino, Vincenzo, and Penagini, Roberto

Abstract

Patients with esophageal symptoms potentially associated to esophageal motor disorders such as dysphagia, chest pain, heartburn and regurgitation, represent one of the most frequent reasons for referral to gastroenterological evaluation. The utility of esophageal manometry in clinical practice is: (1) to accurately define esophageal motor function, (2) to identify abnormal motor function, and (3) to establish a treatment plan based on motor abnormalities. With this in mind, in the last decade, investigations and technical advances, with the introduction of high-resolution esophageal manometry, have enhanced our understanding and management of esophageal motility disorders. The following recommendations were developed to assist physicians in the appropriate use of esophageal manometry in modern patient care. They were discussed and approved after a comprehensive review of the medical literature pertaining to manometric techniques and their recent application. This position statement created under the auspices of the Gruppo Italiano di Studio per la Motilità dell’Apparato Digerente (GISMAD), Società Italiana di Gastroenterologia ed Endoscopia Digestiva (SIGE) and Associazione Italiana Gastroenterologi ed Endoscopisti Digestivi Ospedalieri (AIGO) is intended to help clinicians in applying manometric studies in the most fruitful manner within the context of their patients with esophageal symptoms. [ABSTRACT FROM AUTHOR]

Published
2016
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218. Staying in HRAM's Way: Tweaking the London Classification for Disorders of Anorectal Function.

Author

Bellini, Massimo and Chiarioni, Giuseppe

Subjects
*ESOPHAGEAL motility disorders, *ANORECTAL function tests, *SHORT squeeze, *DEFECATION disorders
Abstract

High-resolution anorectal manometry (HRAM) is a technique wherein intraluminal pressure activity is measured using a series of closely spaced pressure sensors. Furthermore, on the basis of a consensus agreement between internationally recognized experts, the London classification provided a standardized benchmark for performing manometry testing and a system for homogenous classification and diagnostic approach of disordered defecation [[4]]. [Extracted from the article]

Published
2022
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219. Influence of the Serotonin Transporter 5HTTLPR Polymorphism on Symptom Severity in Irritable Bowel Syndrome

Author

Colucci, Rocchina, primary, Gambaccini, Dario, additional, Ghisu, Narcisa, additional, Rossi, Giuseppe, additional, Costa, Francesco, additional, Tuccori, Marco, additional, De Bortoli, Nicola, additional, Fornai, Matteo, additional, Antonioli, Luca, additional, Ricchiuti, Angelo, additional, Mumolo, Maria Gloria, additional, Marchi, Santino, additional, Blandizzi, Corrado, additional, and Bellini, Massimo, additional

Published
2013
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220. Neuroendocrine markers and psychological features in patients with irritable bowel syndrome

Author

Stasi, Cristina, primary, Bellini, Massimo, additional, Costa, Francesco, additional, Mumolo, Maria Gloria, additional, Ricchiuti, Angelo, additional, Grosso, Mariano, additional, Duranti, Emiliano, additional, Metelli, Maria Rosaria, additional, Gambaccini, Dario, additional, Bianchi, Lea, additional, Di Tanna, Gian Luca, additional, Laffi, Giacomo, additional, Taddei, Stefano, additional, and Marchi, Santino, additional

Published
2013
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223. Su1061 How Many Suspected Laryngopharyngeal Reflux are Confirmed as GERD? a MII-pH Study

Author

Martinucci, Irene, primary, de Bortoli, Nicola, additional, Savarino, Edoardo, additional, Nacci, Andrea, additional, Ussia, Valeria, additional, Fattori, Bruno, additional, Bellini, Massimo, additional, Bolognesi, Valeria, additional, Di Fluri, Giorgia, additional, Gemignani, Lorenzo, additional, Berrettini, Stefano, additional, and Marchi, Santino, additional

Published
2012
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224. Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome

Author

Henstrom, Maria, Diekmann, Lena, Bonfiglio, Ferdinando, Hadizadeh, Fatemeh, Kuech, Eva-Maria, von Kockritz-Blickwede, Maren, Thingholm, Louise B, Zheng, Tenghao, Assadi, Ghazaleh, Dierks, Claudia, Heine, Martin, Philipp, Ute, Distl, Ottmar, Money, Mary E, Belheouane, Meriem, Heinsen, Femke-Anouska, Rafter, Joseph, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Walter, Susanna, Simrén, Magnus, Karling, Pontus, Ohlsson, Bodil, Schmidt, Peter T, Lindberg, Greger, Dlugosz, Aldona, Agreus, Lars, Andreasson, Anna, Mayer, Emeran, Baines, John F, Engstrand, Lars, Portincasa, Piero, Bellini, Massimo, Stanghellini, Vincenzo, Barbara, Giovanni, Chang, Lin, Camilleri, Michael, Franke, Andre, Naim, Hassan Y, and D'Amato, Mauro

Abstract

ObjectiveIBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase–isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase–isomaltase (SI) gene variants for their potential relevance in IBS.DesignWe sequenced SIexons in seven familial cases, and screened four CSID mutations (p.Val557Gly, p.Gly1073Asp, p.Arg1124Ter and p.Phe1745Cys) and a common SIcoding polymorphism (p.Val15Phe) in a multicentre cohort of 1887 cases and controls. We studied the effect of the 15Val to 15Phe substitution on SI function in vitro. We analysed p.Val15Phe genotype in relation to IBS status, stool frequency and faecal microbiota composition in 250 individuals from the general population.ResultsCSID mutations were more common in patients than asymptomatic controls (p=0.074; OR=1.84) and Exome Aggregation Consortium reference sequenced individuals (p=0.020; OR=1.57). 15Phe was detected in 6/7 sequenced familial cases, and increased IBS risk in case–control and population-based cohorts, with best evidence for diarrhoea phenotypes (combined p=0.00012; OR=1.36). In the population-based sample, 15Phe allele dosage correlated with stool frequency (p=0.026) and Parabacteroidesfaecal microbiota abundance (p=0.0024). The SI protein with 15Phe exhibited 35% reduced enzymatic activity in vitro compared with 15Val (p<0.05).ConclusionsSIgene variants coding for disaccharidases with defective or reduced enzymatic activity predispose to IBS. This may help the identification of individuals at risk, and contribute to personalising treatment options in a subset of patients.

Published
2018
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225. Functional Heartburn Overlaps With Irritable Bowel Syndrome More Often than GERD

Author

de Bortoli, Nicola, Frazzoni, Leonardo, Savarino, Edoardo V, Frazzoni, Marzio, Martinucci, Irene, Jania, Aleksandra, Tolone, Salvatore, Scagliarini, Michele, Bellini, Massimo, Marabotto, Elisa, Furnari, Manuele, Bodini, Giorgia, Russo, Salvatore, Bertani, Lorenzo, Natali, Veronica, Fuccio, Lorenzo, Savarino, Vincenzo, Blandizzi, Corrado, and Marchi, Santino

Abstract

Objectives:We aimed to evaluate the prevalence of irritable bowel syndrome (IBS) in patients with typical reflux symptoms as distinguished into gastroesophageal reflux disease (GERD), hypersensitive esophagus (HE), and functional heartburn (FH) by means of endoscopy and multichannel intraluminal impedance (MII)-pH monitoring. The secondary aim was to detect pathophysiological and clinical differences between different sub-groups of patients with heartburn.Methods:Patients underwent a structured interview based on questionnaires for GERD, IBS, anxiety, and depression. Off-therapy upper-gastrointestinal (GI) endoscopy and 24 h MII-pH monitoring were performed in all cases. In patients with IBS, fecal calprotectin was measured and colonoscopy was scheduled for values >100 mg/kg to exclude organic disease. Multivariate logistic regression analysis was performed to identify independent risk factors for FH.Results:Of the 697 consecutive heartburn patients who entered the study, 454 (65%) had reflux-related heartburn (GERD+HE), whereas 243 (35%) had FH. IBS was found in 147/454 (33%) GERD/HE but in 187/243 (77%) FH patients (P<0.001). At multivariate analysis, IBS and anxiety were independent risk factors for FH in comparison with reflux-related heartburn (GERD+HE).Conclusions:IBS overlaps more frequently with FH than with GERD and HE, suggesting common pathways and treatment. HE showed intermediate characteristic between GERD and FH.

Published
2017
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230. M1843 Obesity As Risk Factor for Gastroesophageal Disease: Prospective Study

Author

de Bortoli, Nicola, primary, Salvetti, Guido, additional, Pucci, Andrea, additional, Parlanti, Michele, additional, Bellini, Massimo, additional, Costa, Francesco, additional, Mumolo, Maria Gloria, additional, Ricchiuti, Angelo, additional, Santini, Ferruccio, additional, Pinchera, Aldo, additional, and Marchi, Santino, additional

Published
2009
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233. Radionuclide Evaluation of the Lower Gastrointestinal Tract

Author

Mariani, Giuliano, primary, Pauwels, Ernest K.J., additional, AlSharif, Abedallatif, additional, Marchi, Santino, additional, Boni, Giuseppe, additional, Barreca, Marco, additional, Bellini, Massimo, additional, Grosso, Mariano, additional, de Bortoli, Nicola, additional, Mumolo, Gloria, additional, Costa, Francesco, additional, Rubello, Domenico, additional, and Strauss, H. William, additional

Published
2008
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235. Randomised controlled trial of mesalazine in IBS.

Author

Barbara, Giovanni, Cremon, Cesare, Annese, Vito, Basilisco, Guido, Bazzoli, Franco, Bellini, Massimo, Benedetti, Antonio, Benini, Luigi, Bossa, Fabrizio, Buldrini, Paola, Cicala, Michele, Cuomo, Rosario, Germanà, Bastianello, Molteni, Paola, Neri, Matteo, Rodi, Marcello, Saggioro, Alfredo, Scribano, Maria Lia, Vecchi, Maurizio, and Zoli, Giorgio

Subjects
IRRITABLE colon treatment, MESALAMINE, PLACEBOS, ABDOMINAL pain, RANDOMIZED controlled trials, THERAPEUTICS
Abstract

Objective: Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS. Design: We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS. Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, and were followed for additional 12 weeks. The primary efficacy endpoint was satisfactory relief of abdominal pain/ discomfort for at least half of the weeks of the treatment period. The key secondary endpoint was satisfactory relief of overall IBS symptoms. Supportive analyses were also performed classifying as responders patients with a percentage of affirmative answers of at least 75% or >75% of time. Results: A total of 185 patients with IBS were enrolled from 21 centres. For the primary endpoint, the responder patients were 68.6% in the mesalazine group versus 67.4% in the placebo group (p=0.870; 95% CI -12.8 to 15.1). In explorative analyses, with the 75% rule or >75% rule, the percentage of responders was greater in the mesalazine group with a difference over placebo of 11.6% (p=0.115; 95% CI -2.7% to 26.0%) and 5.9% (p=0.404; 95% CI -7.8% to 19.4%), respectively, although these differences were not significant. For the key secondary endpoint, overall symptoms improved in the mesalazine group and reached a significant difference of 15.1% versus placebo (p=0.032; 95% CI 1.5% to 28.7%) with the >75% rule. Conclusions: Mesalazine treatment was not superior than placebo on the study primary endpoint. However, a subgroup of patients with IBS showed a sustained therapy response and benefits from a mesalazine therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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236. Diagnosis and treatment of faecal incontinence: Consensus statement of the Italian Society of Colorectal Surgery and the Italian Association of Hospital Gastroenterologists.

Author

Pucciani, Filippo, Altomare, Donato Francesco, Dodi, Giuseppe, Falletto, Ezio, Frasson, Alvise, Giani, Iacopo, Martellucci, Jacopo, Naldini, Gabriele, Piloni, Vittorio, Sciaudone, Guido, Bove, Antonio, Bocchini, Renato, Bellini, Massimo, Alduini, Pietro, Battaglia, Edda, Galeazzi, Francesca, Rossitti, Piera, and Usai Satta, Paolo

Abstract

Faecal incontinence is a common and disturbing condition, which leads to impaired quality of life and huge social and economic costs. Although recent studies have identified novel diagnostic modalities and therapeutic options, the best diagnostic and therapeutic approach is not yet completely known and shared among experts in this field. The Italian Society of Colorectal Surgery and the Italian Association of Hospital Gastroenterologists selected a pool of experts to constitute a joint committee on the basis of their experience in treating pelvic floor disorders. The aim was to develop a position paper on the diagnostic and therapeutic aspects of faecal incontinence, to provide practical recommendations for a cost-effective diagnostic work-up and a tailored treatment strategy. The recommendations were defined and graded on the basis of levels of evidence in accordance with the criteria of the Oxford Centre for Evidence-Based Medicine, and were based on currently published scientific evidence. Each statement was drafted through constant communication and evaluation conducted both online and during face-to-face working meetings. A brief recommendation at the end of each paragraph allows clinicians to find concise responses to each diagnostic and therapeutic issue. [ABSTRACT FROM AUTHOR]

Published
2015
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241. Empirical trial or diagnostic tests for bile acid diarrhea? That is the question!

Author

Berti, Ginevra, Rettura, Francesco, Lambiase, Christian, and Bellini, Massimo

Subjects
BILE acids, IRRITABLE colon, DIAGNOSIS methods, DIARRHEA, CLOSTRIDIUM diseases
Abstract

12 Smalley W, Falck-Ytter C, Carrasco-Labra A, Wani S, Lytvyn L, Falck-Ytter Y. AGA clinical practice guidelines on the laboratory evaluation of functional diarrhea and diarrhea-predominant irritable bowel syndrome in adults (IBS-D). It is hoped that gastroenterologists, nuclear medicine physicians and laboratory doctors can work closely together to detect normal and shared values of serological tests and compare them with the SeHCAT test, which is currently the gold standard for a BAM diagnosis. In this way the diagnostic tests could become increasingly widespread and made accessible to all patients suspected of BAM or with diarrheic symptoms who need the clearest diagnosis possible. [Extracted from the article]

Published
2021
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242. Relationship of TT virus andHelicobacter pylori infections in gastric tissues of patients with gastritis

Author

Maggi, Fabrizio, primary, Marchi, Santino, additional, Fornai, Claudia, additional, Tempestini, Elena, additional, Andreoli, Elisabetta, additional, Lanini, Letizia, additional, Vatteroni, Maria Linda, additional, Bellini, Massimo, additional, De Bortoli, Nicola, additional, Costa, Francesco, additional, Pistello, Mauro, additional, Specter, Steven, additional, and Bendinelli, Mauro, additional

Published
2003
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243. Ranitidine bismuth citrate-based triple therapy for seven days, with or without further anti-secretory therapy, is highly effective in patients with duodenal ulcer and Helicobacter pylori infection

Author

Marchi, Santino, primary, Costa, Francesco, additional, Bellini, Massimo, additional, Belcari, Claudio, additional, Mumolo, Maria G., additional, Tornar, Alessandro, additional, Spisni, Roberto, additional, Torelli, Ettore, additional, and Maltinti, Giacomo, additional

Published
2001
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246. Role of Low-FODMAP diet in functional dyspepsia: “Why”, “When”, and “to Whom”

Author

Rettura, Francesco, Lambiase, Christian, Grosso, Antonio, Rossi, Alessandra, Tedeschi, Riccardo, Ceccarelli, Linda, and Bellini, Massimo

Abstract

Functional dyspepsia (FD) is a frequent disorder of gut-brain interaction, affecting 5–7% of people globally, with significant impairment in quality of life. The management of FD is challenging due to the lack of specific therapeutic approaches.

Published
2023
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247. 13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids.

Author

Perri, Francesco, Bellini, Massimo, Portincasa, Piero, Parodi, Andrea, Bonazzi, Patrizia, Marzio, Leonardo, Galeazzi, Francesca, Usai, Paolo, Citrino, Attilio, and Usai-Satta, Paolo

Subjects
GASTRIC emptying, BREATH tests, SATURATED fatty acids, INDIGESTION, STABLE isotopes in medical diagnosis, GASTROINTESTINAL motility disorders, STANDARD deviations
Abstract

Abstract: Background: Standardization of the 13C-octanoic acid breath test is still lacking. Aim: To evaluate the accuracy of the 13C-octanoic acid breath test using a new standardized ready-to-eat, gluten-, glucose-, and lactose-free muffin. Methods: Healthy subjects were recruited and sorted by sex and age. Patients with diabetic gastroparesis and untreated celiac disease with known gastric motility disorders were also tested with the new labelled muffin. Expired breath 13CO2 was analysed and t 1/2 was calculated. Results: Overall, 131 healthy subjects were enrolled. The reference range of t 1/2 was 88±29min with the value of 146min as the upper limit of normal range. No significant difference in t 1/2 was found among subjects sorted by sex or age. The within-subject variability of t 1/2 was 17%. Mean (±standard deviation) t 1/2 values were 179±50min in patients with diabetic gastroparesis (n =8) and 151±20min in those with untreated celiac disease (n =11) (p ≤0.001 vs controls). Conclusions: A new standardized test meal simplifies the execution of the 13C-octanoic acid breath test, is not influenced by sex or age, has low intra-individual variability, is palatable, does not cause side effects, and is able to evaluate gastric emptying in both patients and healthy controls. Moreover, it can be used in subjects with lactose intolerance, diabetes, and celiac disease. [Copyright &y& Elsevier]

Published
2010
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248. Innovative Balloon Expulsion Testing for Defecation Disorders: Look Before Leaping the Old Path.

Author

Bellini, Massimo, Lambiase, Christian, and Chiarioni, Giuseppe

Subjects
*DEFECATION disorders, *URINARY catheters, *BIOFEEDBACK training, *PELVIC floor, *ANORECTAL function tests
Abstract

We read with interest the recently published article, "American College of Gastroenterology Clinical Guidelines: Management of Benign Anorectal Disorders", which thoroughly address defecation disorders management ([1]). The Foley catheter BET has been proven as both a reproducible and an effective diagnostic tool for constipation because of outlet dysfunction of diverse origin. [Extracted from the article]

Published
2022
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