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202. The Role of Post-Remission Chemotherapy before T-Cell Depleted Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia in First Complete Remission

Author

Assal, Amer, primary, Jakubowski, Ann A., additional, Maloy, Molly, additional, Zheng, Junting, additional, Devlin, Sean M., additional, Avecilla, Scott, additional, Barker, Juliet N., additional, Castro-Malaspina, Hugo, additional, Dahi, Parastoo, additional, Gyurkocza, Boglarka, additional, Meagher, Richard, additional, Perales, Miguel-Angel, additional, Shaffer, Brian, additional, Tamari, Roni, additional, Young, James W., additional, Giralt, Sergio A., additional, and Papadopoulos, Esperanza B., additional

Published
2016
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203. Double Unit Cord Blood Transplantation (dCBT) Progression-Free Survival (PFS) is Unaffected by Grade III-IV Acute Graft-Versus-Host Disease (aGVHD) and Survivors Are Likely to Discontinue Immunosuppression (IS) and Reconstitute T-Cells

Author

Politikos, Ioannis, primary, Devlin, Sean M., additional, Yoo, Yeon, additional, Lauer, Emily, additional, Ciolino, Cristi, additional, Dierov, Djamilia, additional, Herman, Dara, additional, Mosesso, Kara, additional, Nieves, Jimmy, additional, Giralt, Sergio A., additional, Perales, Miguel-Angel, additional, Kernan, Nancy A., additional, Scaradavou, Andromachi, additional, Ponce, Doris M., additional, and Barker, Juliet N., additional

Published
2016
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204. Low Dose Unfractionated Heparin (UFH) Prophylaxis Is a Feasible Strategy for the Prevention of Hepatic Sinusoidal Obstruction Syndrome (SOS) after Myeloablative Adult Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Author

Bhatt, Valkal, primary, Palazzo, Meighan, additional, Kilroy, Kathleen, additional, Hilden, Patrick, additional, Devlin, Sean M., additional, Maloy, Molly, additional, Barker, Juliet N., additional, Castro-Malaspina, Hugo, additional, Chung, David J., additional, Dahi, Parastoo, additional, Hsu, Katharine C., additional, Hanash, Alan M., additional, Jakubowski, Ann A., additional, Jenq, Robert, additional, Koehne, Guenther, additional, Landau, Heather, additional, Papadopoulos, Esperanza, additional, Perales, Miguel-Angel, additional, Sauter, Craig S., additional, Tamari, Roni, additional, van den Brink, Marcel R.M., additional, Young, James W., additional, Giralt, Sergio A., additional, and Ponce, Doris M., additional

Published
2016
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206. Members of the Intestinal Microbiota Are Associated with Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Peled, Jonathan U., primary, Ling, Lilan, additional, Littman, Eric, additional, Kosuri, Satyajit, additional, Maloy, Molly, additional, Giralt, Sergio A., additional, Barker, Juliet N., additional, Perales, Miguel-Angel, additional, Taur, Ying, additional, Pamer, Eric G., additional, van den Brink, Marcel R.M., additional, and Jenq, Robert, additional

Published
2016
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207. Long-Term Prognosis Among 1-Year Survivors of Ex Vivo T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation: A Landmark Analysis

Author

Cho, Christina, primary, Hsu, Meier, additional, Avecilla, Scott, additional, Barba, Pere, additional, Barker, Juliet N., additional, Castro-Malaspina, Hugo, additional, Devlin, Sean M., additional, Giralt, Sergio A., additional, Jakubowski, Ann A., additional, Koehne, Guenther, additional, Meagher, Richard, additional, O'Reilly, Richard J., additional, Papadopoulos, Esperanza, additional, Ponce, Doris M., additional, van den Brink, Marcel R.M., additional, Young, James W., additional, and Perales, Miguel-Angel, additional

Published
2016
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208. Prospective Evaluation of Cord Blood (CB) and Haplo-Identical (Haplo) Donor Availability Reveals Compromised Donor Access for Both CB and Haplo Grafts in Minority Patients

Author

Kosuri, Satyajit, primary, Wolff, Tara, additional, Lauer, Emily, additional, Byam, Courtney, additional, Yoo, Yeon, additional, Davis, Eric, additional, Paulson, Jennifer, additional, Sideroff, Melissa, additional, Wells, Deborah S., additional, Perales, Miguel-Angel, additional, Scaradavou, Andromachi, additional, Giralt, Sergio A., additional, Ponce, Doris M., additional, and Barker, Juliet N., additional

Published
2016
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209. CD34+ Selected Ex-Vivo T-Cell Depleted (TCD) Grafts for Allogeneic Hematopoietic Cell Transplantation (Allo-HSCT) Is Associated with Low Incidence of Acute and Chronic Graft-Versus-Host Disease (GVHD) and High Chronic-Gvhd/Relapse-Free Survival

Author

Barba, Pere, primary, Hilden, Patrick, additional, Devlin, Sean M., additional, Maloy, Molly, additional, Ciolino, Cristi, additional, Dierov, Djamilia, additional, Herman, Dara, additional, Mosesso, Kara, additional, Nieves, Jimmy, additional, Barker, Juliet N., additional, Castro-Malaspina, Hugo, additional, Jakubowski, Ann A., additional, Koehne, Guenther, additional, Papadopoulos, Esperanza, additional, Sauter, Craig S., additional, van den Brink, Marcel R.M., additional, Young, James W., additional, Giralt, Sergio A., additional, Perales, Miguel-Angel, additional, and Ponce, Doris M., additional

Published
2016
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210. High Progression-Free Survival (PFS) in Adult Double Unit Cord Blood (dCB) Transplant Recipients with High Risk Disease after a Novel Intermediate Intensity Conditioning Regimen

Author

Kosuri, Satyajit, primary, Hilden, Patrick, additional, Devlin, Sean M., additional, Yoo, Yeon, additional, Lauer, Emily, additional, Peled, Jonathan U., additional, Avecilla, Scott, additional, Castro-Malaspina, Hugo, additional, Dahi, Parastoo, additional, Giralt, Sergio A., additional, Gyurkocza, Boglarka, additional, Jakubowski, Ann A., additional, Meagher, Richard, additional, Papadopoulos, Esperanza, additional, Perales, Miguel-Angel, additional, Reich, Lilian, additional, Sauter, Craig S., additional, Scaradavou, Andromachi, additional, Shaffer, Brian, additional, Tamari, Roni, additional, van den Brink, Marcel R.M., additional, Young, James W., additional, Ponce, Doris M., additional, and Barker, Juliet N., additional

Published
2016
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211. Age-Adjusted Co-Morbidity Score - but Not Revised Disease Risk Index - Is Associated with Progression-Free Survival after Intermediate Intensity Double Unit CBT in Adults with Hematologic Malignancies

Author

Kosuri, Satyajit, primary, Hilden, Patrick, additional, Devlin, Sean, additional, Yoo, Yeon, additional, Lauer, Emily, additional, Peled, Jonathan, additional, Parastoo, Dahi B., additional, Giralt, Sergio A., additional, Gyurkocza, Boglarka, additional, Castro-Malaspina, Hugo, additional, Jakubowski, Ann A., additional, Papadopoulos, Esperanza B, additional, Perales, Miguel-Angel, additional, Sauter, Craig S., additional, Shaffer, Brian C, additional, Tamari, Roni, additional, Young, James W., additional, Scaradavou, Andromachi, additional, Ponce, Doris M, additional, and Barker, Juliet N., additional

Published
2015
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212. The Abundance of Certain Bacteria in the Intestinal Flora Is Associated with Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Peled, Jonathan, primary, Littman, Eric R., additional, Ling, Lilan, additional, Kosuri, Satyajit, additional, Maloy, Molly, additional, Giralt, Sergio A., additional, Barker, Juliet N., additional, Perales, Miguel-Angel, additional, Taur, Ying, additional, Pamer, Eric, additional, van den Brink, Marcel, additional, and Jenq, Robert R., additional

Published
2015
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213. Successful Treatment of Refractory CMV Chorioretinitis and Meningoencephalitis with Adoptive Transfer of Third Party CMVpp65 Specific T-Cell Lines

Author

Prockop, Susan, primary, Hasan, Aisha, additional, Doubrovina, Ekaterina, additional, Castro-Malaspina, H.R., additional, Barker, Juliet N., additional, Dahi, Parastoo B, additional, Boulad, Farid, additional, Kernan, Nancy A., additional, Koehne, Guenther, additional, Sauter, Craig S., additional, Kiss, Szilard, additional, Patel, Mrinali, additional, Suser, Stephanie, additional, and O'Reilly, Richard J, additional

Published
2015
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214. Prospective Evaluation of Cord Blood (CB) & Haplo-Identical Donor Availability Reveals Compromised Donor Access for Both Graft Types in Minorities and High Rates of Failure to Clear Haplo Donors in Adult Patients

Author

Kosuri, Satyajit, primary, Wolff, Tara F., additional, Byam, Courtney, additional, Lauer, Emily, additional, Yoo, Yeon, additional, Perales, Miguel-Angel, additional, Giralt, Sergio A., additional, Scaradavou, Andromachi, additional, Ponce, Doris M, additional, and Barker, Juliet N., additional

Published
2015
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215. Successful Treatment of Peripheral T-Cell Lymphoma with Allogeneic Stem Cell Transplantation: A Large Single-Center Experience

Author

Mehta-Shah, Neha, primary, Chou, Joanne, additional, Maloy, Molly, additional, Zhang, Zhigang, additional, Moskowitz, Alison J., additional, Moskowitz, Craig H, additional, Barker, Juliet N., additional, Giralt, Sergio, additional, Perales, Miguel-Angel, additional, Horwitz, Steven M, additional, Sauter, Craig S., additional, and Dahi, Parastoo B., additional

Published
2015
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216. A Prospective Study of Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed/ Refractory Hodgkin Lymphoma

Author

Perales, Miguel-Angel, primary, Cho, Christina, additional, Eaton, Anne, additional, Moskowitz, Alison J, additional, Nguyen, Victoria, additional, Gonzales-Dadiz, Anne Marie R., additional, Devlin, Sean, additional, Giralt, Sergio A., additional, Jakubowski, Ann A., additional, Matasar, Matthew J., additional, Noy, Ariela, additional, Portlock, Carol S., additional, Straus, David J., additional, Young, James W., additional, Barker, Juliet N., additional, and Moskowitz, Craig H., additional

Published
2015
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217. Low Dose Unfractionated Heparin (UFH) Prophylaxis Is a Safe Strategy for the Prevention of Hepatic Sinusoidal Obstruction Syndrome (SOS) in Adult Allogeneic Stem Cell Transplant (HSCT) Recipients

Author

Bhatt, Valkal, primary, Palazzo, Meighan, additional, Kilroy, Kathleen, additional, Hilden, Patrick, additional, Maloy, Molly, additional, Barker, Juliet N., additional, Castro-Malaspina, Hugo R., additional, Chung, David J, additional, Dahi, Parastoo B, additional, Hsu, Katharine C., additional, Hanash, Alan M, additional, Jakubowski, Ann A., additional, Jenq, Robert R., additional, Koehne, Guenther, additional, Landau, Heather, additional, Papadopoulos, Esperanza B, additional, Perales, Miguel-Angel, additional, Sauter, Craig S., additional, Tamari, Roni, additional, van den Brink, Marcel, additional, Young, James W., additional, Giralt, Sergio A., additional, and Ponce, Doris M, additional

Published
2015
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220. 549 - Analysis of Cytomegalovirus (CMV) Infections in the First 180 Days in Adult Sero-Positive Cord Blood Transplantation (CBT) Recipients Reveals High Infection Rates and Treatment Burden

Author

Lau, Carmen, Politikos, Ioannis, Devlin, Sean M., Jacob, Alexandra G., Maloy, Molly, Naputo, Kristine, Afuye, Aishat, Bhatt, Valkal, Dahi, Parastoo B., Perales, Miguel-Angel, Giralt, Sergio A., O'Reilly, Richard J., Ponce, Doris M., Prockop, Susan E., Shah, Gunjan L., Papanicolaou, Genovefa A., Scaradavou, Andromachi, and Barker, Juliet N.

Published
2018
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222. 465 - Disease Progression is Main Barrier to Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in Patients with Newly Diagnosed and Relapsed Acute Leukemia

Author

Preston, Elaina V., Chinapen, Stephanie, Borrill, Taylor, Davis, Eric, Shaffer, Brian C., Tamari, Roni, Jakubowski, Ann A., Perales, Miguel-Angel, Ponce, Doris M., Shah, Gunjan L., Dahi, Parastoo B., Barker, Juliet N., Berman, Ellin, Tallman, Martin, Giralt, Sergio A., Stein, Eytan, and Gyurkocza, Boglarka

Published
2018
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224. 198 - Therapeutic Cyclosporine-a (CSA) Levels in the First 7 Days after Cord Blood Transplantation (CBT) Are Critical to Prevent Severe Acute Graft-Versus-Host Disease (aGVHD)

Author

Bhatt, Valkal, Politikos, Ioannis, Devlin, Sean M., Jacob, Alexandra G., Maloy, Molly, Naputo, Kristine, Afuye, Aishat, Scaradavou, Andromachi, O'Reilly, Richard J., Castro-Malaspina, Hugo, Dahi, Parastoo B., Giralt, Sergio A., Gyurkocza, Boglarka, Jakubowski, Ann A., Papadopoulos, Esperanza B., Peled, Jonathan U., Hanash, Alan M., Perales, Miguel-Angel, Sauter, Craig S., Shaffer, Brian C., Shah, Gunjan L., Tamari, Roni, van den Brink, Marcel R.M., Young, James W., Ponce, Doris M., and Barker, Juliet N.

Published
2018
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225. 197 - Long-Term Follow-Up of Adult Double Unit Cord Blood (CB) Transplantation (dCBT) Recipients Reveals High Rates of Progression-Free Survival after a Novel Cy/ Flu/ Thio/ TBI 400 Intermediate Intensity Conditioning Regimen

Author

Politikos, Ioannis, Devlin, Sean M., Jacob, Alexandra G., Maloy, Molly, Mazis, Christopher, Naputo, Kristine, Afuye, Aishat, Scaradavou, Andromachi, O'Reilly, Richard J., Avecilla, Scott T., Castro-Malaspina, Hugo, Dahi, Parastoo B., Giralt, Sergio A., Gyurkocza, Boglarka, Jakubowski, Ann A., Papadopoulos, Esperanza B., Peled, Jonathan U., Perales, Miguel-Angel, Sauter, Craig S., Shaffer, Brian C., Shah, Gunjan L., Tamari, Roni, van den Brink, Marcel R.M., Young, James W., Ponce, Doris M., and Barker, Juliet N.

Published
2018
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226. Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient.

Author

Bacchus, Melissa, Schmidt, Elizabeth, Lee, Yeon Joo, Papanicolaou, Genovefa A., Chawla, Mohit, and Barker, Juliet N.

Subjects
TUBERCULOSIS, CELL transplantation, IMMUNE reconstitution inflammatory syndrome, CORD blood transplantation, HEMATOPOIETIC stem cells
Abstract

Abstract: Tuberculosis (TB) is an infrequent infection after hematopoietic cell transplant (HCT), with associated mortality up to 30%. The utility of universal screening for latent TB in HCT candidates is controversial due to the lack of sensitive screening tests. We describe a case of disseminated TB infection complicated by immune reconstitution inflammatory syndrome in an adult double unit umbilical cord blood transplant recipient who originated from the United Arab Emirates. [ABSTRACT FROM AUTHOR]

Published
2018
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227. CD34+cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking

Author

Barker, Juliet N., Kempenich, Jane, Kurtzberg, Joanne, Brunstein, Claudio G., Delaney, Colleen, Milano, Filippo, Politikos, Ioannis, Shpall, Elizabeth J., Scaradavou, Andromachi, and Dehn, Jason

Abstract

CD34+cell dose is critical for cord blood (CB) engraftment. However, the CD34+content of the CB inventory in the United States is unknown. We examined the CD34+cell content of 126 341 red blood cell–depleted US units banked from January 2007 to September 2017 with a total nucleated cell (TNC) count of ≥90 × 107and a cryovolume of 24-55 mL. Median pre-cryopreservation TNC content was 127 × 107(interquartile range [IQR], 108-156 × 107); CD34+cell content was 44 × 105(IQR, 29 to 67 × 105). The median CD34+:TNC ratio was 0.34%. TNC and CD34+cell content correlation was weak (r= 0.24). Of 7125 units with TNCs of ≥210 × 107, only 47% had CD34+content of ≥100 × 105. However, some units had high CD34+content for a given TNC count. Only 4% of CB units were acceptable as single-unit grafts (TNCs, ≥2.5 × 107/kg; CD34+cells, ≥1.5 × 105/kg) for 70-kg patients; 22% of units were adequate for 70-kg patients using lower dose criteria (TNCs, ≥1.5 × 107/kg; CD34+cells, ≥1.0 × 105/kg) suitable for a double-unit graft. These findings highlight that units with the highest TNC dose may not have the highest CD34+dose, units with unexpectedly high CD34+content (a ratio of >1.0%) should be verified, and the US CB inventory of adequately sized single units for larger patients is small. They also support the ongoing use of double-unit grafts, a focus on banking high-dose units, and development of expansion technologies.

Published
2019
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229. T-cell depleted stem-cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in 1st complete remission with a decreased risk of graft-versus-host disease

Author

Goldberg, Jenna D., Linker, Alex, Kuk, Deborah, Ratan, Ravin, Jurcic, Joseph, Barker, Juliet N., Castro-Malaspina, Hugo, Giralt, Sergio, Hsu, Katharine, Jakubowski, Ann A., Jenq, Robert, Koehne, Guenther, Papadopoulos, Esperanza B., van den Brink, Marcel R.M., Young, James W., Boulad, Farid, Kernan, Nancy A., O'Reilly, Richard J., Prockop, Susan E., Yahalom, Joachim, Heller, Glenn, and Perales, Miguel-Angel

Subjects
Adult, Male, Adolescent, Remission Induction, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Survival Analysis, Article, Disease-Free Survival, Cohort Studies, Young Adult, surgical procedures, operative, immune system diseases, Recurrence, Humans, Female, Retrospective Studies
Abstract

Consolidation with allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a survival benefit to patients with acute lymphoblastic leukemia (ALL). We have previously reported comparable survival and relapse rates after T cell-depleted (TCD) allo-HSCT compared with unmodified transplantations for acute myelogenous leukemia, myelodysplastic syndrome, and non-Hodgkin lymphoma with significantly decreased graft-versus-host disease (GVHD). We performed a 56-patient retrospective study to evaluate TCD allo-HSCT for the treatment of ALL after myeloablative total body irradiation-based therapy. The 2-year and 5-year overall survival rates for patients with ALL after TCD allo-HSCT were 0.39 (95% confidence interval [CI], 0.26-0.52) and 0.32 (95% CI, 0.19-0.44), respectively, and the 2-year and 5-year disease-free survival rates were 0.38 (95% CI, 0.25-0.50) and 0.32 (95% CI, 0.20-0.44). There was a trend toward improved survival of patients who underwent TCD allo-HSCT in first complete remission compared with those who did so in other remission states. The cumulative incidence of grade II-IV acute GVHD at 1 year was 0.20 (95% CI, 0.10-0.31), and no patients developed grade IV acute GVHD. The cumulative incidence of chronic GVHD in 41 evaluable patients at 2 and 5 years was 0.15 (95% CI, 0.04-0.26), and that of extensive chronic GVHD at 2 and 5 years was 0.05 (95% CI, 0-11.6). We demonstrate OS and DFS rates that compare favorably to unmodified allo-HSCT with lower rates of GVHD.

Published
2012

230. Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord Blood Transplantation

Author

Harnicar, Stephen, primary, Ponce, Doris M., additional, Hilden, Patrick, additional, Zheng, Junting, additional, Devlin, Sean M., additional, Lubin, Marissa, additional, Pozotrigo, Melissa, additional, Mathew, Sherry, additional, Adel, Nelly, additional, Kernan, Nancy A., additional, O'Reilly, Richard, additional, Prockop, Susan, additional, Scaradavou, Andromachi, additional, Hanash, Alan, additional, Jenq, Robert, additional, van den Brink, Marcel, additional, Giralt, Sergio, additional, Perales, Miguel A., additional, Young, James W., additional, and Barker, Juliet N., additional

Published
2015
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231. High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

Author

Ponce, Doris M., primary, Hilden, Patrick, additional, Mumaw, Christen, additional, Devlin, Sean M., additional, Lubin, Marissa, additional, Giralt, Sergio, additional, Goldberg, Jenna D., additional, Hanash, Alan, additional, Hsu, Katharine, additional, Jenq, Robert, additional, Perales, Miguel-Angel, additional, Sauter, Craig, additional, van den Brink, Marcel R. M., additional, Young, James W., additional, Brentjens, Renier, additional, Kernan, Nancy A., additional, Prockop, Susan E., additional, O’Reilly, Richard J., additional, Scaradavou, Andromachi, additional, Paczesny, Sophie, additional, and Barker, Juliet N., additional

Published
2015
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233. Unrelated umbilical cord blood transplant for adult acute lymphoblastic leukemia in first and second complete remission : a comparison with allografts from adult unrelated donors.

Author

Marks, David I, Woo, Kwang Ahn, Zhong, Xiaobo, Appelbaum, Frederick R, Bachanova, Veronika, Barker, Juliet N, Brunstein, Claudio G, Gibson, John, Kebriaei, Partow, Lazarus, Hillard M, Olsson, Richard, Perales, Miguel-Angel, Pidala, Joseph, Savani, Bipin, Rocha, Vanderson, Eapen, Mary, Marks, David I, Woo, Kwang Ahn, Zhong, Xiaobo, Appelbaum, Frederick R, Bachanova, Veronika, Barker, Juliet N, Brunstein, Claudio G, Gibson, John, Kebriaei, Partow, Lazarus, Hillard M, Olsson, Richard, Perales, Miguel-Angel, Pidala, Joseph, Savani, Bipin, Rocha, Vanderson, and Eapen, Mary

Abstract

Allogeneic hematopoietic cell transplantation has an established role in the treatment of adults with acute lymphoblastic leukemia whose survival when recipients of grafts from adult unrelated donors approaches that of recipients of grafts from sibling donors. Our aim was to determine the role of mismatched unrelated cord blood grafts in transplantation for 802 adults with acute lymphoblastic leukemia in first or second complete remission. Using Cox regression we compared outcomes after 116 mismatched single or double cord blood transplants, 546 peripheral blood progenitor cell transplants and 140 bone marrow transplants. The characteristics of the recipients and their diseases were similar except cord blood recipients were younger, more likely to be non-Caucasians and more likely to have a low white blood cell count at diagnosis. There were differences in donor-recipient human leukocyte antigen-match depending on the source of the graft. Most adult donor transplants were matched at the allele-level considering human leukocyte antigens-A, -B, -C and -DRB1. In contrast, most cord blood transplants were mismatched and considered antigen-level matching; 57% were mismatched at two loci and 29% at one locus whereas only 29% of adult donor transplants were mismatched at one locus and none at two loci. There were no differences in the 3-year probabilities of survival between recipients of cord blood (44%), matched adult donor (44%) and mismatched adult donor (43%) transplants. Cord blood transplants engrafted slower and were associated with less grade 2-4 acute but similar chronic graft-versus-host disease, relapse, and transplant-related mortality. The survival of cord blood graft recipients was similar to that of recipients of matched or mismatched unrelated adult donor grafts and so cord blood should be considered a valid alternative source of stem cells for adults with acute lymphoblastic leukemia in the absence of a matched unrelated adult donor.

Published
2014
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234. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy

Author

Eapen, Mary, Klein, John P, Ruggeri, Annalisa, Spellman, Stephen, Lee, Stephanie J, Anasetti, Claudio, Arcese, William, Barker, Juliet N, Baxter-Lowe, Lee Ann, Brown, Maria, Fernandez-Vina, Marcelo A, Freeman, John, He, Wensheng, Iori, Anna Paola, Horowitz, Mary M, Locatelli, Franco, Marino, Susana, Maiers, Martin, Michel, Gerard, Sanz, Guillermo F, Gluckman, Eliane, Rocha, Vanderson, Locatelli, Franco (ORCID:0000-0002-7976-3654), Eapen, Mary, Klein, John P, Ruggeri, Annalisa, Spellman, Stephen, Lee, Stephanie J, Anasetti, Claudio, Arcese, William, Barker, Juliet N, Baxter-Lowe, Lee Ann, Brown, Maria, Fernandez-Vina, Marcelo A, Freeman, John, He, Wensheng, Iori, Anna Paola, Horowitz, Mary M, Locatelli, Franco, Marino, Susana, Maiers, Martin, Michel, Gerard, Sanz, Guillermo F, Gluckman, Eliane, Rocha, Vanderson, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles. NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLA-matched units. The observed effects are independent of cell dose and patient age. These data support allele-level HLA matching in the selection of single UCB units.

Published
2014

236. Analysis of 129 Myeloablative Double-Unit Cord Blood Transplantation Recipients Demonstrates an Independent Association Between Non-Dominant Unit TNC Dose and Engraftment Suggesting a Facilitation Effect

Author

Purtill, Duncan, primary, Lubin, Marissa N, additional, Ponce, Doris M., additional, Giralt, Sergio, additional, Perales, Miguel-Angel, additional, O'Reilly, Richard J, additional, Van Den Brink, Marcel, additional, Young, James W., additional, Scaradavou, Andromachi, additional, Stevens, Cladd, additional, and Barker, Juliet N., additional

Published
2014
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237. Day 45 Lymphocyte Recovery Is Independently Associated with Transplant-Related Mortality after Adult Myeloablative Double-Unit Cord Blood Transplantation (dCBT)

Author

Purtill, Duncan, primary, Ponce, Doris M., additional, Devlin, Sean M., additional, Lubin, Marissa N, additional, Dahi, Parastoo B, additional, Giralt, Sergio A, additional, Perales, Miguel-Angel, additional, O'Reilly, Richard J., additional, van den Brink, Marcel R.M., additional, Young, James W., additional, Scaradavou, Andromachi, additional, Stevens, Cladd, additional, and Barker, Juliet N., additional

Published
2014
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238. Successful Salvage of High-Risk B-Cell Non-Hodgkin and Hodgkin Lymphoma with Double-Unit Cord Blood Transplantation Provides a Platform for Further Optimization

Author

Dahi, Parastoo B, primary, Sauter, Craig S., additional, Devlin, Sean M., additional, Lubin, Marissa N, additional, Ponce, Doris M., additional, Giralt, Sergio, additional, Koehne, Guenther, additional, Perales, Miguel-Angel, additional, Zelenetz, Andrew D., additional, Moskowitz, Craig H., additional, and Barker, Juliet N., additional

Published
2014
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239. Autoimmune Hemolysis & Immune Thrombocytopenic Purpura after Cord Blood Transplantation (CBT) May be Life-Threatening & Warrants Early Therapy with Rituximab

Author

Bhatt, Valkal, primary, Shune, Leyla, additional, Lauer, Emily J, additional, Lubin, Marissa N, additional, Devlin, Sean M., additional, Scaradavou, Andromachi, additional, Kernan, Nancy A., additional, Giralt, Sergio, additional, Parameswaran, Rekha, additional, Perales, Miguel-Angel, additional, Ponce, Doris M., additional, Soff, Gerald A., additional, and Barker, Juliet N., additional

Published
2014
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240. Double-Unit Cord Blood (CB) Transplantation (DCBT) Combined with Haplo-Identical CD34+ Selected Peripheral Blood Stem Cells (PBSC) Is Associated with Enhanced Neutrophil Recovery, Universal Haplo Rejection and Frequent Pre-Engraftment Syndrome

Author

Sanchez, Matias Eugenio, primary, Ponce, Doris M., additional, Lauer, Emily J, additional, Lubin, Marissa N, additional, Barone, Jonathan, additional, Byam, Courtney, additional, Dahi, Parastoo B, additional, Meagher, Richard, additional, Castro-Malaspina, Hugo, additional, Jakubowski, Ann A., additional, Koehne, Guenther, additional, Papadopoulos, Esperanza B, additional, Perales, Miguel-Angel, additional, Sauter, Craig S., additional, Tamari, Roni, additional, Scaradavou, Andromachi, additional, Kernan, Nancy A., additional, Giralt, Sergio, additional, O'Reilly, Richard J, additional, and Barker, Juliet N., additional

Published
2014
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241. Myeloablative Double-Unit Cord Blood Transplantation (CBT) in Pediatric Patients with High-Risk Acute Leukemia Demonstrates Encouraging Disease-Free Survival with Both TBI and Chemotherapy-Only-Based Conditioning

Author

Scaradavou, Andromachi, primary, Lubin, Marissa N, additional, Hilden, Patrick, additional, Boulad, Farid, additional, Curran, Kevin J., additional, Kobos, Rachel, additional, Prockop, Susan E., additional, O'Reilly, Richard J., additional, Tonon, Jo-Ann, additional, Byam, Courtney, additional, Steinherz, Peter G, additional, Shukla, Neerav, additional, Hasan, Aisha, additional, Renaud, Thomas M., additional, Zakak, Nicole, additional, Kernan, Nancy A., additional, and Barker, Juliet N., additional

Published
2014
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242. Third Party Donor Derived CMV Specific T Cells for the Treatment of Refractory CMV Viremia and Disease after Hematopoietic Stem Cell Transplant

Author

Prockop, Susan E., primary, Hasan, Aisha, additional, Koehne, Guenther, additional, Doubrovina, Ekaterina, additional, Sauter, Craig S., additional, Barker, Juliet N,, additional, Baroudy, Karim, additional, Boulad, Farid, additional, Giralt, Sergio, additional, Khalaf, Ramzi, additional, Kernan, Nancy A., additional, Papadopoulos, Esperanza B, additional, Ponce, Doris M., additional, Scaradavou, Andromachi, additional, Suser, Stephanie, additional, Wasilewski, Gloria, additional, and O'Reilly, Richard J., additional

Published
2014
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243. Allogeneic Transplantation for Chronic Myelomonocytic Leukemia (CMML) Is Associated with High Disease-Free Survival Even in the Setting of High-Risk Disease

Author

Sanchez, Matias Eugenio, primary, Abbi, Kamal Kant Singh, additional, Tamari, Roni, additional, Jakubowsky, Ann, additional, Papadopoulos, Esperanza B, additional, Devlin, Sean M., additional, Shi, Weiji, additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Boulad, Farid, additional, Giralt, Sergio, additional, Meagher, Richard, additional, and Castro-Malaspina, Hugo, additional

Published
2014
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245. Disease-Free Survival in Adult Patients with Acute Leukemia and Advanced CML Supports Use of Double-Unit Cord Blood Grafts As an Immediate Alternative to 8/8 HLA-Matched Unrelated Donors (URD)

Author

Ponce, Doris M., primary, Hilden, Patrick, additional, Devlin, Sean M., additional, Maloy, Molly, additional, Lubin, Marissa N, additional, Castro-Malaspina, H.R., additional, Goldberg, Jenna D, additional, Jakubowski, Ann A., additional, Meagher, Richard, additional, Papadopoulos, Esperanza B, additional, Perales, Miguel-Angel, additional, Sauter, Craig S., additional, van den Brink, Marcel R.M., additional, Young, James W., additional, Kernan, Nancy A., additional, O'Reilly, Richard J, additional, Scaradavou, Andromachi, additional, Giralt, Sergio, additional, and Barker, Juliet N., additional

Published
2014
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246. Dominant unit CD34+ cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice

Author

Purtill, Duncan, primary, Smith, Katherine, additional, Devlin, Sean, additional, Meagher, Richard, additional, Tonon, Joann, additional, Lubin, Marissa, additional, Ponce, Doris M., additional, Giralt, Sergio, additional, Kernan, Nancy A., additional, Scaradavou, Andromachi, additional, Stevens, Cladd E., additional, and Barker, Juliet N., additional

Published
2014
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247. 67 - Using Haplogictm & Recipient Ancestry: The Likelihood of Identifying an 8/8 HLA-Matched Unrelated Donor Can be Accurately Predicted at the Time of the Preliminary Search Markedly Improving Search Efficiency & Speed to Allograft: An 830 Patient Analysis

Author

Davis, Eric, Devlin, Sean M., Cooper, Candice, Nhaissi, Melissa, Paulson, Jennifer, Wells, Deborah S., Scaradavou, Andromachi, Giralt, Sergio A., Papadopoulos, Esperanza B., Kernan, Nancy A., Byam, Courtney, and Barker, Juliet N.

Published
2017
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248. 262 - Graft-Versus Host Disease (GVHD Status and Severity Mediate Late Effects of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in a 1-Year Landmark Analysis

Author

Sola, Maria, Devlin, Sean M., Maloy, Molly, Dierov, Djamilia, Barker, Juliet N., Castro-Malaspina, Hugo, Dahi, Parastoo, Jakubowski, Ann A., Koehne, Guenther, Papadopoulos, Esperanza B., Sauter, Craig S., Tamari, Roni, van den Brink, Marcel R.M., Young, James W., Giralt, Sergio A., Perales, Miguel-Angel, and Ponce, Doris M.

Published
2017
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