201. Antidiabetic and antioxidant effects of sage tea, Salvia officinalis in male rats exposed to hydrogen peroxide as a source of reactive oxygen species.
- Author
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Mohammad Bakir, Sahib M. H., Al-Hiti, Sadiq M. A., Al-Naimi, Rajiha A. S., and Ali, Dina T.
- Subjects
SAGE ,HYPOGLYCEMIC agents ,HYDROGEN peroxide ,REACTIVE oxygen species ,BLOOD sampling - Abstract
The antidiabetic and antioxidant effects of Salvia officinalis (sage tea) were studied in 20 mature male rats for 42 days. The rats were divided into four equal groups and given the following treatments: group one as a control group (C), rats only received tap water; group two (T
1 ) received 0.5% H2 O2 as a source of reactive oxygen species (ROS); group three (T2 ) received sage tea as 2 mg sage in 150 mL boiling water (ad libitum); and group four (T3 ) received 400 IU/Kg BW/day vitamin E by oral intubation along with 0.5% H2 O2 . In order to determine serum glucose levels, blood samples were taken directly from the heart after the end of the experiment. Rats were slaughtered, and pancreas samples were collected for patho-histological analysis. The serum glucose levels in the sage tea with the H2 O2 group (T2 ) and T3 as compared to the second group (T1 ) showed a significant decrease (p ˂ 0.05). Histological examination revealed significant recovery of the pancreatic tissues especially islets of Langerhans in sage tea and vitamin E rats (T3 ). This investigation suggests the antidiabetic effect of sage tea for H2 O2 - induced diabetic rats mediated by their effect as antioxidants. [ABSTRACT FROM AUTHOR]- Published
- 2024
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