2,000 results on '"A, Del Maschio"'
Search Results
202. Prognostic utility of diffusion-weighted MRI in oesophageal cancer: is apparent diffusion coefficient a potential marker of tumour aggressiveness?
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Alessandro Del Maschio, A. Salerno, Francesco De Cobelli, Carlo Staudacher, Luca Albarello, Alessandro Ambrosi, Francesco Giganti, Damiano Chiari, Antonio Esposito, Elena Orsenigo, Elena Mazza, Giganti, F, Salerno, A, Ambrosi, Alessandro, Chiari, D, Orsenigo, E, Esposito, Antonio, Albarello, L, Mazza, E, Staudacher, C, DEL MASCHIO, Alessandro, and DE COBELLI, Francesco
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Male ,medicine.medical_specialty ,Esophageal Neoplasms ,Biopsy ,medicine.medical_treatment ,Population ,Contrast Media ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,Organometallic Compounds ,medicine ,Humans ,Effective diffusion coefficient ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,education ,Survival analysis ,Neoadjuvant therapy ,Aged ,Neoplasm Staging ,Univariate analysis ,education.field_of_study ,business.industry ,Reproducibility of Results ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,030220 oncology & carcinogenesis ,Disease Progression ,Population study ,Female ,Radiology ,Neoplasm Grading ,business - Abstract
To investigate the role of the apparent diffusion coefficient (ADC) as a potential prognostic biomarker in the evaluation of the aggressiveness of oesophageal cancer.Between November 2009 and December 2013, 43 patients with evidence of oesophageal or oesophago-gastric junction cancer were referred to our institution and prospectively entered in our database. The final study population consisted of 23 patients (18 men; 5 women; mean age, 64.62 ± 10.91 years) who underwent diffusion-weighted Magnetic Resonance before surgical intervention. Specifically, 14 were directly treated with surgery and 9 were addressed to chemo/radiotherapy beforehand. Two radiologists independently measured mean tumour ADC and inter-observer agreement (Spearman's and intraclass correlation coefficient [ICC]) was assessed. In the univariate analysis, overall survival curves related to pathological ADC, pT, pN, tumour location and histotype were fitted using the Kaplan-Meier method. Survival curves were then compared using the log-rank test.Inter-observer reproducibility was very good (Spearman's rho = 0.95; ICC = 0.94). At a total median follow-up of 19 months (2-49 months), 4 patients had died. The median follow-up was 18.50 months (5-49 months) for the surgery-only group (1/4 events, 25 %) and 24 months (2-34 months) for the chemo/radiotherapy group (3/4 events, 75 %). Survival time at 48 months for the overall population was 59 % (±0.11), while for the surgery-only group and the chemo/radiotherapy group was 90 % (±0.09) and 61 % (±0.34), respectively. In the univariate analysis, ADC values below or equal to 1.4 × 10(-3) mm(2)/s were associated with a negative prognosis both in the total population (P = 0.016) and in the surgery-only group (P 0.001).Despite the biggest limitation of our study (i.e. the small study population), we were able to show that pathological ADC could be considered a prognostic factor for oesophageal cancer. DWI might be introduced into clinical practice as a promising and reliable technique in the diagnostic pathway of this tumour.
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- 2015
203. Apparent Diffusion Coefficient Value and Ratio as Noninvasive Potential Biomarkers to Predict Prostate Cancer Grading: Comparison With Prostate Biopsy and Radical Prostatectomy Specimen
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Francesco De Cobelli, Francesco Giganti, Silvia Ravelli, Francesco Montorsi, Antonio Esposito, Alessandro Del Maschio, Andrea Gallina, DE COBELLI, Francesco, Ravelli, S, Esposito, Antonio, Giganti, F, Gallina, A, Montorsi, Francesco, and DEL MASCHIO, Alessandro
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Adult ,Male ,medicine.medical_specialty ,Prostate biopsy ,Biopsy ,medicine.medical_treatment ,Population ,Prostate cancer ,Predictive Value of Tests ,medicine ,Humans ,Effective diffusion coefficient ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,education ,Grading (tumors) ,Aged ,Aged, 80 and over ,Prostatectomy ,education.field_of_study ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Prostate ,Prostatic Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,body regions ,Diffusion Magnetic Resonance Imaging ,Radiology ,Neoplasm Grading ,business ,Nuclear medicine - Abstract
OBJECTIVE. The purpose of this study is to test the association between diffusion-weighted MRI and prostate cancer Gleason score at both biopsy and final pathologic analysis after radical prostatectomy. SUBJECTS AND METHODS. Patients with prostate cancer (n = 72) underwent diffusion-weighted MRI (b values, 0, 800, and 1600 s/mm(2)) with an endorectal coil. Apparent diffusion coefficient (ADC) and ADC ratio were obtained in normal and pathologic tissue and were correlated with transrectal ultrasound-guided biopsy (n = 72) and histopathologic (n = 39) Gleason scores using the ANOVA test. ADC accuracy was estimated using ROC curves. RESULTS. Lesions suspicious for prostate cancer were detected in 65 patients. The mean ADC was 1.47 and 0.87 × 10(-3) mm(2)/s for normal and pathologic tissue, respectively (p < 0.001). When we divided the population into four groups (normal tissue and biopsy Gleason scores of 6, 7, and 8-10), then the mean ADC value was 1.47, 0.96, 0.80, and 0.78 × 10(-3) mm(2)/s, respectively (p < 0.001). The ADC ratio decreased along with an increase in biopsy Gleason score (66.9%, 56.7%, and 51.5% for Gleason scores of 6, 7 and 8-10, respectively) (ANOVA, p = 0.003) and pathologic Gleason score (ANOVA, p < 0.001). ROC curves had an AUC of 0.94 and 0.86 for ADC and ADC ratio, respectively (p = 0.012 and 0.042, respectively). CONCLUSION. Decreasing ADC values may represent a strong risk factor of harboring a poorly differentiated prostate cancer, independently of biopsy characteristics.
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- 2015
204. Serum Resistin and Hepatic Fat Content in Nondiabetic Individuals
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Perseghin, Gianluca, Lattuada, Guido, De Cobelli, Francesco, Ntali, Georgia, Esposito, Antonio, Burska, Agata, Belloni, Elena, Canu, Tamara, Ragogna, Francesca, Scifo, Paola, Del Maschio, Alessandro, and Luzi, Livio
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- 2006
205. Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes
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Zerbini, Gianpaolo, Bonfanti, Riccardo, Meschi, Franco, Bognetti, Emilio, Paesano, Pier Luigi, Gianolli, Luigi, Querques, Marialuisa, Maestroni, Anna, Calori, Giliola, Del Maschio, Alessandro, Fazio, Ferruccio, Luzi, Livio, and Chiumello, Giuseppe
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- 2006
206. Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease: 019
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Bonfanti, R., Perseghin, G., Magni, S., De Cobelli, F., Canu, T., Scifo, P., Del Maschio, A., Luzi, L., and Chiumello, G.
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- 2006
207. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
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Fragasso, Gabriele, Perseghin, Gianluca, De Cobelli, Francesco, Esposito, Antonio, Palloshi, Altin, Lattuada, Guido, Scifo, Paola, Calori, Giliola, Del Maschio, Alessandro, and Margonato, Alberto
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- 2006
208. Successful endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after pancreas transplantation
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Orsenigo, Elena, De Cobelli, Francesco, Salvioni, Marco, Cristallo, Marco, Fiorina, Paolo, Del Maschio, Alessandro, Di Carlo, Valerio, and Secchi, Antonio
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- 2003
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209. Bidirectional modulation of platelet and polymorphonuclear leukocyte activities
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Del Maschio, A., Dejana, E., and Bazzoni, G.
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- 1993
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210. ISLET TRANSPLANTATION ALONE: ROLE OF SIROLIMUS IN EARLY ENGRAFTMENT: OR-146
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de Taddeo, Francesca, Maffi, Paola, Bertuzzi, Federico, Nano, Rita, Piemonti, Lorenzo, Melzi, Raffaella, Magistretti, Paola, Venturini, Massimo, Del Maschio, Alessandro, and Secchi, Antonio
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- 2005
211. Islet Transplantation Is Associated With an Improvement of Cardiovascular Function in Type 1 Diabetic Kidney Transplant Patients
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FIORINA, PAOLO, GREMIZZI, CHIARA, MAFFI, PAOLA, CALDARA, ROSSANA, TAVANO, DAVIDE, MONTI, LUCILLA, SOCCI, CARLO, FOLLI, FRANCO, FAZIO, FERRUCCIO, ASTORRI, ETTORE, DEL MASCHIO, ALESSANDRO, and SECCHI, ANTONIO
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- 2005
212. Natural History of Kidney Graft Survival, Hypertrophy, and Vascular Function in End-Stage Renal Disease Type 1 Diabetic Kidney-Transplanted Patients: Beneficial impact of pancreas and successful islet cotransplantation
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FIORINA, PAOLO, VENTURINI, MASSIMO, FOLLI, FRANCO, LOSIO, CLAUDIO, MAFFI, PAOLA, PLACIDI, CLAUDIA, LA ROSA, STEFANO, ORSENIGO, ELENA, SOCCI, CARLO, CAPELLA, CARLO, DEL MASCHIO, ALESSANDRO, and SECCHI, ANTONIO
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- 2005
213. Postabsorptive and insulin-stimulated energy and protein metabolism in patients with myotonic dystrophy type 1
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Perseghin, Gianluca, Comola, Mauro, Scifo, Paola, Benedini, Stefano, De Cobelli, Francesco, Lanzi, Roberto, Costantino, Federica, Lattuada, Guido, Battezzati, Alberto, Del Maschio, Alessandro, and Luzi, Livio
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- 2004
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214. Magnetic resonance imaging of the kidney in Type 1 (insulin-dependent) diabetes mellitus
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Mangili, R., Sironi, S., Rankel, G., Makarovic, M., Zerbini, G., Del Maschio, A., and Pozza, G.
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- 1992
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215. Intrapancreatic accessory spleen mimicking a neuroendocrine tumor: magnetic resonance findings and possible diagnostic role of different nuclear medicine tests
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Brasca, L. E., Zanello, A., De Gaspari, A., De Cobelli, F., Zerbi, A., Fazio, F., and Del Maschio, A.
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- 2004
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216. Bilingualism and aging: Why research should continue.
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Del Maschio, Nicola, Fedeli, Davide, and Abutalebi, Jubin
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AGING ,BILINGUALISM ,EXPERIMENTAL design ,NEUROPROTECTIVE agents - Abstract
Whether bilingualism acts positively against neurocognitive decline is intensely debated. Although some reasons for it might be ideological, variability in sampling procedures and experimental design represent potential sources of inconsistency among studies. In this paper, we contend that bilingualism renders the extra-years of life of an increasingly long-lived population cognitively healthy, but only under specific conditions such as continuous practice and immersion in bilingual environments. We thus disagree with some authors' recommendation that bilingualism be removed from consideration as a neuroprotective factor. We suggest, at the same time, that bilingualism should not be treated as axiologically superior to other environmental measures that promise to contrast the progressive loss of functional independence with increasing age. We conclude by emphasizing the need to evaluate the protective effects of L2-learning on the aging brain in a multimodal intervention perspective, thereby dissociating the effects of bilingualism from those of other cognitively stimulating factors. [ABSTRACT FROM AUTHOR]
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- 2021
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217. L-Arginine-Induced Vasodilation of the Renal Vasculature Is Preserved in Uremic Type 1 Diabetic Patients After Kidney and Pancreas but not After Kidney-Alone Transplantation
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De Cobelli, Francesco, Fiorina, Paolo, Perseghin, Gianluca, Magnone, Marta, Venturini, Massimo, Zerbini, Gianpaolo, Zanello, Alessandro, Mazzolari, Gabriella, Monti, Lucilla, Di Carlo, Valerio, Secchi, Antonio, and Del Maschio, Alessandro
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- 2004
218. Long-Term Beneficial Effect of Islet Transplantation on Diabetic Macro-/Microangiopathy in Type 1 Diabetic Kidney-Transplanted Patients
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Fiorina, Paolo, Folli, Franco, Bertuzzi, Federico, Maffi, Paola, Finzi, Giovanna, Venturini, Massimo, Socci, Carlo, Davalli, Alberto, Orsenigo, Elena, Monti, Lucilla, Falqui, Luca, Uccella, Silvia, Rosa, Stefano La, Usellini, Luciana, Properzi, Giuliana, Di Carlo, Valerio, Del Maschio, Alessandro, Capella, Carlo, and Secchi, Antonio
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- 2003
219. Energy Metabolism in Diabetic and Nondiabetic Heart Transplant Recipients
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Benedini, Stefano, Fiocchi, Roberto, Battezzati, Alberto, Scifo, Paola, Sereni, Lucia Piceni, Gamba, Amando, Mammana, Carmelo, Del Maschio, Alessandro, Perseghin, Gianluca, and Luzi, Livio
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- 2002
220. Preoperative multiparametric MRI of the prostate for the prediction of lymph node metastases in prostate cancer patients treated with extended pelvic lymph node dissection
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Lisa Brunetti, Giorgio Brembilla, Giulia Cristel, Paolo Dell'Oglio, Antonio Esposito, Alessandro Del Maschio, Anna Damascelli, Francesco Montorsi, Armando Stabile, Alberto Briganti, Massimo Freschi, Francesco De Cobelli, Alessandro Ambrosi, Brembilla, Giorgio, Dell’Oglio, Paolo, Stabile, Armando, Ambrosi, Alessandro, Cristel, Giulia, Brunetti, Lisa, Damascelli, Anna, Freschi, Massimo, Esposito, Antonio, Briganti, Alberto, Montorsi, Francesco, Del Maschio, Alessandro, and de Cobelli, Francesco
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Male ,medicine.medical_specialty ,Radiology, Nuclear Medicine and Imaging ,medicine.medical_treatment ,030232 urology & nephrology ,Lymph node dissection ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Magnetic resonance imaging ,Prostate ,Tumour volume ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,Lymph node ,Aged ,Retrospective Studies ,Prostatectomy ,Univariate analysis ,medicine.diagnostic_test ,business.industry ,Prostatic Neoplasms ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,Preoperative Period ,Lymph Node Excision ,Lymphadenectomy ,Radiology ,Lymph Nodes ,Neoplasm Grading ,business - Abstract
To assess the role of preoperative multiparametric MRI (mpMRI) of the prostate in the prediction of nodal metastases in patients treated with radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). We retrospectively analyzed 101 patients who underwent both preoperative mpMRI of the prostate and RP with ePLND at our institution. For each patient, complete preoperative clinical data and tumour characteristics at mpMRI were recorded. Final histopathologic stage was considered the standard of reference. Univariate and multivariate logistic regression analyses were performed. Nodal metastases were found in 23/101 (22.8%) patients. At univariate analyses, all clinical and radiological parameters were significantly associated to nodal invasion (all p
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- 2017
221. Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer
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Alessandro Ambrosi, Carlo Staudacher, Antonio Esposito, Alessandro Del Maschio, Francesco De Cobelli, Luca Albarello, Elena Orsenigo, Damiano Chiari, Francesco Giganti, Elena Mazza, Giganti, Francesco, Ambrosi, Alessandro, Chiari, Damiano, Orsenigo, Elena, Esposito, Antonio, Mazza, Elena, Albarello, Luca, Staudacher, Carlo, DEL MASCHIO, Alessandro, and DE COBELLI, Francesco
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Cancer Research ,medicine.medical_specialty ,TNM staging ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Effective diffusion coefficient ,Radical surgery ,Stage (cooking) ,medicine.diagnostic_test ,business.industry ,gastric cancer ,Cancer ,Magnetic resonance imaging ,Histology ,medicine.disease ,body regions ,Oncology ,Apparent diffusion coefficient ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Original Article ,diffusion-weighted magnetic resonance imaging ,Radiology ,prognosis ,Nuclear medicine ,business - Abstract
OBJECTIVE To investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC). METHODS Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging (local invasion, nodal involvement and according to the different groups - stage I, II and III). Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. RESULTS Median follow-up period was 33 months and 45/89 (51%) deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement (P
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- 2017
222. Salvage Islet Auto Transplantation After Relaparatomy
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Giovanni Capretti, Lorenzo Piemonti, P. Magistretti, Rita Nano, Gianpaolo Balzano, Massimo Venturini, Raffaelli Melzi, Paola Maffi, Francesca Aleotti, Francesco De Cobelli, Marina Scavini, Antonio Secchi, Alessia Mercalli, Massimo Falconi, Cesare Berra, Francesca Gavazzi, Alessandro Del Maschio, Alessandro Zerbi, Pathology/molecular and cellular medicine, Balzano, Gianpaolo, Nano, Rita, Maffi, Paola, Mercalli, Alessia, Melzi, Raffaelli, Aleotti, Francesca, Gavazzi, Francesca, Berra, Cesare, DE COBELLI, Francesco, Venturini, Massimo, Magistretti, Paola, Scavini, Marina, Capretti, Giovanni, DEL MASCHIO, Alessandro, Secchi, Antonio, Zerbi, Alessandro, Falconi, Massimo, and Piemonti, Lorenzo
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Islets of Langerhans Transplantation ,030230 surgery ,Transplantation, Autologous ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Pancreatectomy ,Postoperative Complications ,Pancreatitis, Chronic ,Journal Article ,Medicine ,Humans ,Aged ,Retrospective Studies ,Salvage Therapy ,geography ,Transplantation ,geography.geographical_feature_category ,business.industry ,Research Support, Non-U.S. Gov't ,Graft Survival ,Retrospective cohort study ,Middle Aged ,Pancreaticoduodenectomy ,Islet ,medicine.disease ,Surgery ,Survival Rate ,Italy ,030220 oncology & carcinogenesis ,Cohort ,Pancreatitis ,Female ,business ,Follow-Up Studies - Abstract
BACKGROUND: To assess feasibility, safety, and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding after pancreatic surgery. METHODS: From November 2008 to October 2016, approximately 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n = 11) or bleeding (n = 11). Feasibility, efficacy, and safety of salvage IAT were compared with those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%, P = 0.008), mainly because of a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT(78.9% vs 20%, P < 0.001), there was no evidence of a higher rate of complications related to the procedure. Median follow-up was 5.45 ± 0.52 years. Four (36%) of 11 patients reached insulin independence, 6 patients (56%) had partial graft function, and 1 patient (9%) had primary graft nonfunction. At the last follow-up visit, median fasting C-peptide was 0.43 (0.19-0.93) ng/mL; median insulin requirement was 0.38 (0.04-0.5) U/kg per day, and median HbA1c was 6.6% (5.9%-8.1%). Overall mortality, in-hospital mortality, metabolic outcome, graft survival, and insulin-free survival after salvage IAT were not different from those documented after simultaneous IAT. CONCLUSIONS: Our data demonstrate the feasibility, efficacy, and safety of salvage IAT after relaparotomy.
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- 2017
223. Could early tumour volume changes assessed on morphological MRI predict the response to chemoradiation therapy in locally-advanced rectal cancer?
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Palmisano, A., Esposito, A., Di Chiara, A., Ambrosi, A., Passoni, P., Slim, N., Fiorino, C., Albarello, L., Di Muzio, N., Calandrino, R., Rosati, R., Del Maschio, A., De Cobelli, F., PALMISANO , ANNA, Palmisano, A., Esposito, A., Di Chiara, A., Ambrosi, A., Passoni, P., Slim, N., Fiorino, C., Albarello, L., Di Muzio, N., Calandrino, R., Rosati, R., Del Maschio, A., and De Cobelli, F.
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Adult ,Male ,Radiology, Nuclear Medicine and Imaging ,Colorectal cancer ,Adenocarcinoma ,Drug Administration Schedule ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,Aged ,medicine.diagnostic_test ,business.industry ,Rectal Neoplasms ,Cancer ,Magnetic resonance imaging ,General Medicine ,Chemoradiotherapy, Adjuvant ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Oxaliplatin ,Tumor Burden ,Treatment Outcome ,Fluorouracil ,030220 oncology & carcinogenesis ,Female ,Nuclear medicine ,business ,Chemoradiotherapy ,medicine.drug - Abstract
Aim: To investigate the potential role of an additional magnetic resonance imaging (MRI) examination performed during neoadjuvant chemoradiation therapy (CRT) in the prediction of pathological response in locally advanced rectal cancer (LARC). Material and methods: Forty-eight consecutive patients with LARC underwent neoadjuvant CRT. MRI studies at 1.5 T, including high-resolution T2-weighted sequences that were acquired parallel and perpendicular to the main axis of the tumour were performed before (preMRI), during (midMRI), and 6-8 weeks after the end of CRT (postMRI). Cancer volumes (Vpre, Vmid, Vpost) were drawn manually and the reduction rate calculated (ÎVmid, ÎVpost). According to Rödel's pathological tumour regression grade (TRG), patients were considered non-responders (NR; TRG0-2), partial responders (PR; TRG3), and complete responders (CR; TRG4). Multivariate regression analysis was performed to identify the best MRI predictors of NR, PR, and CR. Results: Twenty-five patients were considered PR (52%), 13 CR (27%), and 10 NR (22%). Tumour shrinkage mainly occurred shortly after CRT (ÎVmid: CR: 80±10% versus PR: 56±19% versus NR: 28±22%, p=2.2Ã10-16). Vmid, Vpost, ÎVmid, and ÎVpostcorrelated with TRG (p
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- 2017
224. Microwave ablation of liver malignancies: comparison of effects and early outcomes of percutaneous and intraoperative approaches with different liver conditions
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Marco Salvioni, Alessandro Ambrosi, Francesca Ratti, Alessandro Del Maschio, Michele Colombo, Paolo Marra, Massimo Venturini, Anna Damascelli, Claudio Sallemi, Simone Gusmini, Luca Aldrighetti, Pietro Diana, Francesco De Cobelli, Federica Cipriani, DE COBELLI, Francesco, Marra, Paolo, Ratti, Francesca, Ambrosi, Alessandro, Colombo, Michele, Damascelli, Anna, Sallemi, Claudio, Gusmini, Simone, Salvioni, Marco, Diana, Pietro, Cipriani, Federica, Venturini, Massimo, Aldrighetti, Luca, and DEL MASCHIO, Alessandro
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Liver metastase ,Male ,Cancer Research ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Cirrhosis ,Percutaneous ,Ablation zone (AZ) ,medicine.medical_treatment ,Colorectal cancer (CRC) ,Complete ablation (CA) ,Hepatocellular carcinoma (HCC) ,Liver metastases ,Microwave ablation (MWA) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,medicine ,Humans ,Microwaves ,Aged ,Chemotherapy ,business.industry ,Liver Neoplasms ,Microwave ablation ,Hematology ,General Medicine ,medicine.disease ,Ablation ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Catheter Ablation ,Female ,Radiology ,business ,Ex vivo - Abstract
Liver thermal ablation is an alternative treatment for hepatocellular carcinoma (HCC) and secondary liver malignancies. Microwave ablation (MWA) produces large ablation zones (AZ) in short time; however, AZ prediction is based on preclinical ex vivo models, rising concerns about reproducibility and safety in humans. We aimed to investigate the effects produced by a new-generation MWA system on human liver in vivo with different approaches (percutaneous or intraoperative) and liver conditions (cirrhosis or previous chemotherapy treatment), in comparison with manufacturer-provided predictions based on ex vivo animal models. Complete tumor ablation (CA) and early clinical outcomes were also assessed. From October 2014, 60 consecutive patients (cirrhotic = 31; non-cirrhotic = 10; chemotherapy-treated = 19) with 81 liver nodules (HCC = 31; mets = 50) underwent MWA procedures (percutaneous = 30; laparotomic = 18; laparoscopic = 12), with a 2450 MHz/100 W generator with Thermosphere™ Technology (Emprint™, Medtronic). A contrast-enhanced CT or MR was performed after one month to assess CA and measure AZ. A linear correlation between AZ volumes and ablation times was observed in vivo, without differences from manufacturer-provided ex vivo predictions in all operative approaches and liver conditions. Other independent variables (sex, age, nodule location) showed no relationship when added to the model. Median (IQR) longitudinal and transverse roundness-indexes of the AZs were, respectively, 0.77(0.13) and 0.93(0.11). CA at 1 month was 93% for percutaneous and 100% for intraoperative procedures (p = 0.175). Thirty-day morbidity and mortality were 3% and 0%. MWA with Thermosphere™ Technology produces predictable AZs on human liver in vivo, according to manufacturer-provided ex vivo predictions. In our experience, this new-generation MWA system is effective and safe to treat liver malignancies in different operative and clinical settings.
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- 2017
225. Anterior cingulate cortex sulcation and its differential effects on conflict monitoring in bilinguals and monolinguals
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Albert Costa, Christophe Pallier, Grégoire Borst, Pasquale Anthony Della Rosa, Olivier Houdé, Nicola Del Maschio, Jubin Abutalebi, Arnaud Cachia, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ - UMR 8240), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie cognitive - Psychologie cognitive expérimentale (UNICOG-U992), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Saclay (COmUE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center of Brain and Cognition, Universitat Pompeu Fabra [Barcelona] (UPF), Centre de Psychiatrie et Neurosciences (U894), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Neuroimagerie cognitive (UNICOG-U992), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Universitat Pompeu Fabra [Barcelona], Cachia, Arnaud, Del Maschio, Nicola, Borst, Gregoire, Della Rosa, Pasquale Anthony, Pallier, Christophe, Costa, Albert, Houdé, Olivier, and Abutalebi, Jubin
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Adult ,Male ,Linguistics and Language ,Cognitive Neuroscience ,Cognitive efficiency ,Experimental and Cognitive Psychology ,Multilingualism ,behavioral disciplines and activities ,Gyrus Cinguli ,050105 experimental psychology ,Language and Linguistics ,03 medical and health sciences ,Speech and Hearing ,[SCCO]Cognitive science ,Young Adult ,0302 clinical medicine ,Cognition ,medicine ,Humans ,0501 psychology and cognitive sciences ,10. No inequality ,Neuroscience of multilingualism ,Anterior cingulate cortex ,[SCCO.NEUR]Cognitive science/Neuroscience ,05 social sciences ,Differential effects ,stomatognathic diseases ,medicine.anatomical_structure ,nervous system ,Female ,Psychology ,030217 neurology & neurosurgery ,psychological phenomena and processes ,Cognitive psychology - Abstract
International audience; The role of the anterior cingulate cortex (ACC) in modulating the effect of bilingual experience on cognitive control has been reported at both functional and structural neural levels. Individual differences in the ACC sulcal patterns have been recently correlated with cognitive control efficiency in monolinguals. We aimed to investigate whether differences of ACC sulcation mediate the effect of bilingualism on cognitive control efficiency. We contrasted the performance of bilinguals and monolinguals during a cognitive control task (i.e., the Flanker Task) using a stratification based on the participants' ACC sulcal features. We found that performance of the two groups was differentially affected by ACC sulcation. Our findings provide the first evidence that early neuro-developmental mechanisms may modulate the effect of different environmental backgrounds-here, bilingual vs monolingual experience-on cognitive efficiency.
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- 2017
226. Oesophageal cancer staging: a minefield of measurements-author's reply
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Francesco De Cobelli, Alessandro Ambrosi, Antonio Esposito, Alessandro Del Maschio, Francesco Giganti, Giganti, Francesco, Ambrosi, Alessandro, Esposito, Antonio, DEL MASCHIO, Alessandro, and DE COBELLI, Francesco
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,General surgery ,medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,030218 nuclear medicine & medical imaging ,Cancer staging - Published
- 2017
227. Pre-treatment MDCT-based texture analysis for therapy response prediction in gastric cancer: Comparison with tumour regression grade at final histology
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Elena Mazza, Damiano Chiari, Elena Orsenigo, Sofia Antunes, Paolo Marra, A. Salerno, Carlo Staudacher, Roberto Nicoletti, Luca Albarello, Francesco Giganti, Antonio Esposito, Alessandro Ambrosi, Francesco De Cobelli, Alessandro Del Maschio, Giganti, Francesco, Marra, Paolo, Ambrosi, Alessandro, Salerno, Annalaura, Antunes, Sofia, Chiari, Damiano, Orsenigo, Elena, Esposito, Antonio, Mazza, Elena, Albarello, Luca, Nicoletti, Roberto, Staudacher, Carlo, DEL MASCHIO, Alessandro, and DE COBELLI, Francesco
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Male ,medicine.medical_specialty ,Multivariate analysis ,Biopsy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Stomach Neoplasms ,Multidetector Computed Tomography ,medicine ,Effective diffusion coefficient ,Humans ,Radiology, Nuclear Medicine and imaging ,Radical surgery ,Aged ,Neoplasm Staging ,Univariate analysis ,Receiver operating characteristic ,business.industry ,Area under the curve ,Univariate ,General Medicine ,Odds ratio ,Middle Aged ,Combined Modality Therapy ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Female ,Radiology ,business - Abstract
Purpose An accurate prediction of tumour response to therapy is fundamental in oncology, so as to prompt personalised treatment options if needed. The aim of this study was to investigate the ability of preoperative texture analysis from multi-detector computed tomography (MDCT) in the prediction of the response rate to neo-adjuvant therapy in patients with gastric cancer. Material and methods Thirty-four patients with biopsy-proven gastric cancer were examined by MDCT before neo-adjuvant therapy, and treated with radical surgery after treatment completion. Tumour regression grade (TRG) at final histology was also assessed. Image features from texture analysis were quantified, with and without filters for fine to coarse textures. Patients with TRG 1–3 were considered responders while TRG 4–5 as non- responders . The response rate to neo-adjuvant therapy was assessed both at univariate and multivariate analysis. Results Fourteen parameters were significantly different between the two subgroups at univariate analysis; in particular, entropy and compactness (higher in responders ) and uniformity (lower in responders ). According to our model, the following parameters could identify non-responders at multivariate analysis: entropy (≤6.86 with a logarithm of Odds Ratio − Log OR −: 4.11; p = 0.003); range (>158.72; Log OR: 3.67; p = 0.010) and root mean square (≤3.71; Log OR: 4.57; p = 0.005). Entropy and three-dimensional volume were not significantly correlated ( r = 0.06; p = 0.735). Conclusion Pre-treatment texture analysis can potentially provide important information regarding the response rate to neo-adjuvant therapy for gastric cancer, improving risk stratification.
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- 2017
228. Endovascular Treatment of Visceral Artery Aneurysms and Pseudoaneurysms in 100 Patients: Covered Stenting vs Transcatheter Embolization
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Germano Melissano, Marco Alparone, Michele Colombo, Claudio Sallemi, R. Castellano, Luca Aldrighetti, Gianpaolo Balzano, Luca Bertoglio, Yamume Tshomba, Simone Gusmini, Massimo Venturini, Roberto Chiesa, Massimo Falconi, Marco Salvioni, Francesco De Cobelli, Giulia Agostini, Alessandro Del Maschio, Paolo Marra, Venturini, Massimo, Marra, Paolo, Colombo, Michele, Alparone, Marco, Agostini, Giulia, Bertoglio, Luca, Sallemi, Claudio, Salvioni, Marco, Gusmini, Simone, Balzano, Gianpaolo, Castellano, Renata, Aldrighetti, Luca, Tshomba, Yamume, Falconi, Massimo, Melissano, Germano, De Cobelli, Francesco, Chiesa, Roberto, and Del Maschio, Alessandro
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Male ,endovascular treatment ,Radiology, Nuclear Medicine and Imaging ,Time Factors ,Visceral artery ,Databases, Factual ,Computed Tomography Angiography ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,aneurysm ,covered stent ,endovascular aneurysm repair ,stent-graft ,transcatheter embolization ,visceral artery ,Radiology ,Nuclear Medicine and Imaging ,Cardiology and Cardiovascular Medicine ,Endovascular aneurysm repair ,030218 nuclear medicine & medical imaging ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,Endovascular Procedures ,Middle Aged ,Settore MED/22 - CHIRURGIA VASCOLARE ,Embolization, Therapeutic ,Treatment Outcome ,Stents ,Aneurysm, False ,Adult ,medicine.medical_specialty ,Transcatheter embolization ,Risk Assessment ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Aneurysm ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Endovascular treatment ,Vascular Patency ,Covered stent ,Aged ,Retrospective Studies ,business.industry ,Angiography, Digital Subtraction ,medicine.disease ,Blood Vessel Prosthesis ,Viscera ,Surgery ,business - Abstract
Purpose: To retrospectively report a large single-center experience of visceral artery aneurysms (VAAs) and pseudoaneurysms (VAPAs) treated with covered stenting (CS) as the first therapeutic option vs transcatheter embolization (TE). Methods: One hundred patients (mean age 59±14 years; 58 men) underwent 59 elective and 41 emergent endovascular procedures to treat 51 VAAs and 49 VAPAs. Seventy patients had TE and 30 received CS (27 Viabahn and 3 coronary stent grafts). Both TE and CS were performed in 10 cases. Results: Technical success was 96% (97% CS, 96% TE), and 30-day clinical success was 83% (87% CS, 81.4% TE). Four major complications occurred; 30-day mortality was 7%, mainly due to septic shock following pancreatic surgery. The midterm follow-up was 20.8 months in the total population and 32.8 months in the CS group. More than 6 months after CS all aneurysms remained excluded; stent patency was achieved in 88%. Twelve CS patients with >3 years’ follow-up had maintained stent patency. Conclusion: In endovascular treatment of visceral aneurysms, covered stenting was feasible in 30%. CS showed a slightly better efficacy than TE and good midterm patency. The Viabahn covered stent seems to be suitable for endovascular repair of tortuous visceral arteries affected by true or false aneurysms.
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- 2017
229. Endovascular Repair of 40 Visceral Artery Aneurysms and Pseudoaneurysms with the Viabahn Stent-Graft: Technical Aspects, Clinical Outcome and Mid-Term Patency
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Michele Colombo, Simone Gusmini, Paolo Marra, Marco Salvioni, Gianpaolo Balzano, Massimo Venturini, Claudio Sallemi, Roberto Chiesa, Yamume Tshomba, Alessandro Del Maschio, Carolina Lanza, Massimo Falconi, Germano Melissano, Francesco De Cobelli, Giulia Agostini, Marta Panzeri, Venturini, Massimo, Marra, Paolo, Colombo, Michele, Panzeri, Marta, Gusmini, Simone, Sallemi, Claudio, Salvioni, Marco, Lanza, Carolina, Agostini, Giulia, Balzano, Gianpaolo, Tshomba, Yamume, Melissano, Germano, Falconi, Massimo, Chiesa, Roberto, De Cobelli, Francesco, and Del Maschio, Alessandro
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Male ,Time Factors ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Splenic artery ,Radiography, Interventional ,Endovascular aneurysm repair ,Arterial intervention ,Interventional radiology ,Pseudoaneurysm ,Stent-graft ,Visceral aneurysm ,Adult ,Aged ,Aged, 80 and over ,Aneurysm ,Aneurysm, False ,Blood Vessel Prosthesis Implantation ,Endovascular Procedures ,Female ,Follow-Up Studies ,Gastrointestinal Tract ,Hepatic Artery ,Humans ,Middle Aged ,Prospective Studies ,Renal Artery ,Retrospective Studies ,Splenic Artery ,Treatment Outcome ,Vascular Patency ,Stents ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Nuclear Medicine and Imaging ,80 and over ,medicine.diagnostic_test ,Interventional ,Settore MED/22 - CHIRURGIA VASCOLARE ,Dissection ,surgical procedures, operative ,Cardiology ,Radiology ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,03 medical and health sciences ,Radiology, Nuclear Medicine and Imaging ,medicine.artery ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,business.industry ,Stent ,medicine.disease ,False ,Surgery ,Radiography ,business - Abstract
Purpose Endovascular repair of true visceral artery aneurysms (VAAs) and pseudoaneurysms (VAPAs) with stent-grafting (SG) can simultaneously allow aneurysm exclusion and vessel preservation, minimizing the risk of ischemic complications. Our aim was to report a single-center experience on SG of visceral aneurysms, focusing on technical aspects, clinical outcome and mid-term patency.Materials and Methods Consecutive patients affected by VAAs-VAPAs and submitted to endovascular treatment were retrospectively reviewed, and SG cases with the self-expandable peripheral Viabahn stent-graft were analyzed (2003-2017). Aneurysm type, patient number, SG clinical setting, procedural data, peri-procedural complications, technical success, 30-day clinical success, 30-day mortality and follow-up period (aneurysm exclusion, stent-graft patency, ischemic complications) were analyzed.Results SG was performed in 40 patients (24 VAPAs/16 VAAs) and in 44 procedures (25 in emergency, 19 in elective treatments), via transfemoral in 37 cases (transaxillary in 7 cases). One peri-procedural complication was recorded (a splenic artery dissection successfully converted to transcatheter embolization). The overall technical and clinical success rates were, respectively, 96 and 84%, with excellent trend in elective treatments (both 100%). Overall 30-day mortality was 12.5% (septic shock after pancreatic surgery). Stent-graft thrombosis occurred in 2 patients within 3 months, with aneurysm exclusion and without ischemic complications. Stent-graft patency and aneurysm exclusion were confirmed at 6, 12 and 36 months in 18, 12 and 7 patients, respectively.Conclusion SG of VAAs and VAPAs was safe and effective, particularly in elective treatments. The Viabahn stent-graft, flexible and without shape memory, is suitable for endovascular repair of tortuous visceral arteries.
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- 2017
230. Assessment of Endometrial Carcinoma by Magnetic Resonance Imaging and Ultrasound
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del Maschio, A., primary, Vanzulli, A., additional, Sironi, S., additional, De Cobelli, F., additional, and Spagnolo, D., additional
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- 1998
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231. Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception*
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Perseghin, Gianluca, Scifo, Paola, Pagliato, Emanuela, Battezzati, Alberto, Benedini, Stefano, Soldini, Laura, Testolin, Giulio, Del Maschio, Alessandro, and Luzi, Livio
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- 2001
232. Effects of Kidney-Pancreas Transplantation on Atherosclerotic Risk Factors and Endothelial Function in Patients With Uremia and Type 1 Diabetes
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Fiorina, Paolo, La Rocca, Ennio, Venturini, Massimo, Minicucci, Fabio, Fermo, Isabella, Paroni, Rita, D'Angelo, Armando, Sblendido, Marisa, Di Carlo, Valerio, Cristallo, Marco, Del Maschio, Alessandro, Pozza, Guido, and Secchi, Antonio
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- 2001
233. Cardiac CT With Delayed Enhancement in the Characterization of Ventricular Tachycardia Structural Substrate
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Paolo Della Bella, Paola M.V. Rancoita, Sofia Antunes, Giuseppe Maccabelli, Giovanna Rizzo, Anna Palmisano, Francesca Baratto, Caterina Colantoni, Francesco De Cobelli, Clelia Di Serio, Antonio Esposito, and Alessandro Del Maschio
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Scars ,Catheter ablation ,030204 cardiovascular system & hematology ,Ablation ,Ventricular tachycardia ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Radiofrequency catheter ablation ,Predictive value of tests ,Heart rate ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Computed tomography angiography - Abstract
Objectives This study sought to compare myocardial scars depicted by computed tomography (CT) with electrical features from electro-anatomic mapping (EAM), assessing the potential role of CT integration in ventricular tachycardia (VT) and radiofrequency catheter ablation (RFCA) procedures. Background Imaging-based characterization of VT myocardial substrate is required to plan EAM and, potentially, to guide RFCA. Methods Forty-two consecutive patients, 35 of whom had implantable cardioverter-defibrillator, all referred for VT RFCA, underwent pre-procedural CT including an angiographic and a 10-min delayed-enhancement scan. Segmental comparison between scars segmented from CT and low voltages (bipolar voltages Results CT scans identified scars in 39 patients and defined left ventricular wall involvement and mural distribution. Overall segmental concordance between CT and EAM was good (κ = 0.536) despite the presence of implantable cardioverter-defibrillator, scar etiologies, and mural distribution. CT identified segments characterized by low voltages with good sensitivity (76%), good specificity (86%), and very high negative predictive value (95%). Late potentials and RF ablation points fell on scarred segments identified from CT in 79% and 81% of cases, respectively. Point-by-point quantitative comparison revealed good correlation between the average area of scar detected at CT and at bipolar mapping (CT = 4,901 mm 2 , bipolar voltages-EAM = 4,070 mm 2 ; R = 0.78; p Conclusions CT with delayed-enhancement provides a 3-dimensional characterization of VT scar substrate together with a detailed anatomic model of the heart. This information may offer assistance to plan EAM and RFCA procedures and is potentially suitable for EAM-imaging integration.
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- 2016
234. Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis
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Pier Alberto Testoni, Elisabetta Goni, Gioacchino Leandro, Margherita Bianco, Giulia Martina Cavestro, Milena Di Leo, Raffaella Alessia Zuppardo, Francesco Di Mario, Mario Guslandi, Alberto Mariani, Satish K. Singh, Teresa Marzia Rogger, Francesco De Cobelli, Alessandro Del Maschio, Di Leo, Milena, Leandro, Gioacchino, Singh, Satish K., Mariani, Alberto, Bianco, Margherita, Zuppardo, Raffaella Alessia, Goni, Elisabetta, Rogger, Teresa Marzia, Di Mario, Francesco, Guslandi, Mario, DE COBELLI, Francesco, DEL MASCHIO, Alessandro, Testoni, PIER ALBERTO, and Cavestro, GIULIA MARTINA
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Pancreatic disease ,Alcohol Drinking ,Cholangiopancreatography, Magnetic Resonance ,Endocrinology, Diabetes and Metabolism ,Drinking ,Pancreas divisum ,Cystic Fibrosis Transmembrane Conductance Regulator ,Gastroenterology ,03 medical and health sciences ,CFTR gene ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Pancreatitis, Chronic ,medicine ,Internal Medicine ,Humans ,Pancreatitis, chronic ,Pancreas ,Irritable bowel syndrome ,Univariate analysis ,Magnetic resonance cholangiopancreatography ,medicine.diagnostic_test ,Hepatology ,business.industry ,Smoking ,Pancreatic Diseases ,Odds ratio ,Middle Aged ,medicine.disease ,Male sex ,Logistic Models ,Smoking threshold ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Mutation ,Pancreatitis ,030211 gastroenterology & hepatology ,Female ,business ,Alcohol and tobacco - Abstract
Objectives The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP). Methods Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome. Results We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35). Conclusions In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.
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- 2016
235. Screening women at intermediate risk: harm or charm?
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Panizza, Pietro, Viganò, Sara, Bonelli, Luigina, Bazzocchi, Massimo, Belli, Paolo, Calabrese, Massimo, Caramella, Davide, Corcione, Stefano, Del Maschio, Alessandro, Martincich, Laura, Montemezzi, Stefania, Pediconi, Federica, Petrillo, Antonella, Sardanelli, Francesco, and Bruzzi, Paolo
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- 2012
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236. Elevated fasting plasma C-peptide occurs in non-diabetic individuals with fatty liver, irrespective of insulin resistance
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A. Del Maschio, Georgia Ntali, Elena Belloni, Francesca Ragogna, Andrea Caumo, Tamara Canu, Guido Lattuada, P. Scifo, Gianluca Perseghin, F. De Cobelli, Antonio Esposito, Livio Luzi, Perseghin, G, Caumo, A, Lattuada, G, De Cobelli, F, Ntali, G, Esposito, A, Belloni, E, Canu, T, Ragogna, F, Scifo, P, Del Maschio, A, Luzi, L, DE COBELLI, Francesco, Esposito, Antonio, DEL MASCHIO, Alessandro, and Luzi, L.
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Reference Values ,Internal medicine ,Diabetes mellitus ,Magnetic resonance spectroscopy ,Blood plasma ,Internal Medicine ,medicine ,Humans ,MED/13 - ENDOCRINOLOGIA ,Pancreatic hormone ,Retrospective Studies ,B-Lymphocytes ,Free fatty acid ,C-Peptide ,C-peptide ,business.industry ,Intra-hepatic fat ,Insulin ,Fatty liver ,Fasting ,Homeostasis model assessment ,medicine.disease ,Fatty Liver ,chemistry ,Female ,Insulin Resistance ,business ,Body mass index - Abstract
AIMS: Studies have pointed to insulin resistance as a pathogenic factor in fatty liver. Although pancreatic B-cell function is believed to be involved, its role is unclear. This study was undertaken to test whether fasting C-peptide, an index of fasting B-cell function, was related to intra-hepatic fat (IHF) content in non-diabetic humans. METHODS: We assessed, retrospectively, fasting plasma C-peptide concentration in 31 patients with fatty liver and 62 individuals without fatty liver. The IHF content was measured by proton magnetic resonance spectroscopy ((1)H-MRS), while insulin sensitivity was estimated based on fasting plasma glucose and insulin with the homestasis model assessment (HOMA) 2 method. RESULTS: Age, sex and body mass index (BMI) were not different between groups. Patients with fatty liver had higher fasting insulin (P < 0.01), C-peptide (P < 0.005) and lower insulin sensitivity (HOMA2-%S). Fasting insulin alone explained 14% of the IHF content variability (P < 0.001); inclusion of fasting C-peptide in multivariate regression explained up to 32% (P < 0.001). A subgroup analysis was performed by matching 1 : 1 for HOMA2-%S. These data were analysed by conditional logistic regression which showed that, when HOMA2-%S was matched between groups, fasting C-peptide remained the only significant predictor of fatty liver. CONCLUSIONS: Non-diabetic individuals with fatty liver are characterized by increased fasting plasma C-peptide concentration, irrespective of their insulin resistant state. AIMS: Studies have pointed to insulin resistance as a pathogenic factor in fatty liver. Although pancreatic B-cell function is believed to be involved, its role is unclear. This study was undertaken to test whether fasting C-peptide, an index of fasting B-cell function, was related to intra-hepatic fat (IHF) content in non-diabetic humans. METHODS: We assessed, retrospectively, fasting plasma C-peptide concentration in 31 patients with fatty liver and 62 individuals without fatty liver. The IHF content was measured by proton magnetic resonance spectroscopy ((1)H-MRS), while insulin sensitivity was estimated based on fasting plasma glucose and insulin with the homestasis model assessment (HOMA) 2 method. RESULTS: Age, sex and body mass index (BMI) were not different between groups. Patients with fatty liver had higher fasting insulin (P < 0.01), C-peptide (P < 0.005) and lower insulin sensitivity (HOMA2-%S). Fasting insulin alone explained 14% of the IHF content variability (P < 0.001); inclusion of fasting C-peptide in multivariate regression explained up to 32% (P < 0.001). A subgroup analysis was performed by matching 1 : 1 for HOMA2-%S. These data were analysed by conditional logistic regression which showed that, when HOMA2-%S was matched between groups, fasting C-peptide remained the only significant predictor of fatty liver. CONCLUSIONS: Non-diabetic individuals with fatty liver are characterized by increased fasting plasma C-peptide concentration, irrespective of their insulin resistant state.
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- 2009
237. Value of [ 11C]choline-Positron Emission Tomography for Re-Staging Prostate Cancer: A Comparison With [ 18F]fluorodeoxyglucose-Positron Emission Tomography
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PICCHIO, M., MESSA, C., LANDONI, C., GIANOLLI, L., SIRONI, S., BRIOSCHI, M., MATARRESE, M., MATEI, D.V., DE COBELLI, F., DEL MASCHIO, A., ROCCO, F., RIGATTI, P., and FAZIO, F.
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- 2003
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238. Secretin MRCP and endoscopic pancreatic manometry in the evaluation of sphincter of Oddi function: a comparative pilot study in patients with idiopathic recurrent pancreatitis
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Mariani, Alberto, Curioni, Simona, Zanello, Alessandro, Passaretti, Sandro, Masci, Enzo, Rossi, Marzia, Del Maschio, Alessandro, and Testoni, Pier Alberto
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- 2003
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239. Endovascular Treatment of a Noninfected Anastomotic Juxtarenal Aortic Aneurysm
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Melissano, Germano, Di Mario, Carlo, Tshomba, Yamume, Civilini, Efrem, Gimelli, Giorgio, Nicoletti, Roberto, Del Maschio, Alessandro, Colombo, Antonio, and Chiesa, Roberto
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- 2000
240. Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (JAM)
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Del Maschio, Aldo, De Luigi, Ada, Martin-Padura, Ines, Brockhaus, Manfred, Bartfai, Tamas, Fruscella, Paolo, Adorini, Luciano, Martino, Gian Vito, Furlan, Roberto, De Simoni, Maria Grazia, and Dejana, Elisabetta
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- 1999
241. Intramyocellular Triglyceride Content Is a Determinant of in Vivo Insulin Resistance in Humans: A1 H-(13) C Nuclear Magnetic Resonance Spectroscopy Assessment in Offspring of Type 2 Diabetic Parents
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Perseghin, Gianluca, Scifo, Paola, De Cobelli, Francesco, Pagliato, Emanuela, Battezzati, Alberto, Arcelloni, Cinzia, Vanzulli, Angelo, Testolin, Giulio, Pozza, Guido, Del Maschio, Alessandro, and Luzi, Livio
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- 1999
242. Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
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Elena Belloni, Georgia Ntali, Alessandro Del Maschio, Guido Lattuada, Tamara Canu, Francesco De Cobelli, Francesca Ragogna, Gianluca Perseghin, Antonio Esposito, Paola Scifo, Livio Luzi, Perseghin, G, Lattuada, G, De Cobelli, F, Esposito, A, Belloni, E, Ntali, G, Ragogna, F, Canu, T, Scifo, P, Del Maschio, A, Luzi, L, DE COBELLI, Francesco, Esposito, Antonio, DEL MASCHIO, Alessandro, and Luzi, L.
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Adult ,Male ,medicine.medical_specialty ,Phosphocreatine ,Heart Ventricles ,medicine.medical_treatment ,Diastole ,Adipose tissue ,Adipokine ,Biology ,Ventricular Function, Left ,chemistry.chemical_compound ,Adenosine Triphosphate ,Internal medicine ,Adipocytes ,medicine ,Humans ,Insulin ,MED/13 - ENDOCRINOLOGIA ,Anthropometry ,Hepatology ,Myocardium ,Fatty liver ,Mediastinum ,Lipid metabolism ,Lipid Metabolism ,medicine.disease ,Fatty Liver ,Endocrinology ,Blood pressure ,Adipose Tissue ,chemistry ,Case-Control Studies ,Energy Metabolism - Abstract
Fatty liver is characterized by metabolic abnormalities at the liver, but also at skeletal muscle and adipose tissue sites. It is hypothesized that the heart may be suffering metabolic alterations, and this study was undertaken to ascertain whether individuals with fatty liver have left ventricular (LV) alterations of energy metabolism, structure, and function and abnormal amounts of epicardial fat as a specific marker of visceral fat accumulation. To this end we studied young, nondiabetic men matched for anthropometric features with (n = 21) or without (n = 21) fatty liver by means of (1) cardiac magnetic resonance imaging (MRI); (2) cardiac 31P-MR spectroscopy (MRS); and (3) hepatic 1H-MRS to assess quantitatively the intrahepatic fat (IHF) content. Insulin sensitivity was determined by the updated HOMA-2 computer model. Individuals with fatty liver showed reduced insulin sensitivity, increased serum free fatty acid (FFA), and E-selectin, abnormal adipokine concentrations, and higher blood pressure. LV morphology and systolic and diastolic functions were not different; however, in the scanned intrathoracic region, the intrapericardial (7.8 ± 3.1 versus 5.9 ± 2.5 cm2; P < 0.05) and extrapericardial (11.7 ± 6.1 versus 7.8 ± 3.2 cm2; P < 0.03) fat was increased in men with fatty liver compared with those without fatty liver. 1The phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio, a recognized in vivo marker of myocardial energy metabolism, was reduced in men with fatty liver in comparison with normals (1.85 ± 0.35 versus 2.11 ± 0.31; P < 0.016). In conclusion, in newly found individuals with fatty liver, fat was accumulated in the epicardial area and despite normal LV morphological features and systolic and diastolic functions, they had abnormal LV energy metabolism. Copyright © 2007 by the American Association for the Study of Liver Diseases
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- 2007
243. Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With Insulin Resistance
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Federica Costantino, Livio Luzi, Francesco De Cobelli, Francesca Ragogna, Paola Scifo, Tamara Canu, Elena Belloni, Antonio Esposito, Gianluca Perseghin, Alessandro Del Maschio, Georgia Ntali, Guido Lattuada, Perseghin, G, Ntali, G, DE COBELLI, Francesco, Lattuada, G, Esposito, Antonio, Belloni, E, Canu, T, Costantino, F, Ragogna, F, Scifo, P, DEL MASCHIO, Alessandro, Luzi, L., De Cobelli, F, Esposito, A, Del Maschio, A, and Luzi, L
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Systole ,Endocrinology, Diabetes and Metabolism ,Diastole ,Overweight ,Body Mass Index ,Ventricular Dysfunction, Left ,Insulin resistance ,Reference Values ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Body Size ,Humans ,Insulin ,Obesity ,MED/13 - ENDOCRINOLOGIA ,Advanced and Specialized Nursing ,business.industry ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Blood pressure ,Endocrinology ,Insulin Resistance ,Metabolic syndrome ,medicine.symptom ,Energy Metabolism ,business ,Body mass index - Abstract
OBJECTIVE—Perturbations in cardiac energy metabolism might represent early alterations in diabetes preceding functional and pathological changes. We evaluated left ventricular (LV) structure/geometry and function in relation to energy metabolism and cardiovascular risk factors in overweight/obese men using magnetic resonance techniques. RESEARCH DESIGN AND METHODS—We studied 81 healthy men (aged 22–55 years, with BMI between 19 and 35 kg/m2) by means of cardiac magnetic resonance imaging and 31P-magnetic resonance spectroscopy in the resting and fasted conditions and stratified them in quartiles of BMI (cut offs: 23.2, 25.5 and 29.0 kg/m2). RESULTS—LV mass increased across quartiles of BMI; meanwhile, the volumes did not differ. Parameters of LV systolic and diastolic function were not different among quartiles. The phosphocreatine-to-ATP ratio was reduced across increasing quartiles of mean ± SD BMI (2.25 ± 0.52, 1.89 ± 0.26, 1.99 ± 0.38, and 1.79 ± 0.29; P < 0.006) in association with insulin sensitivity (computer homeostasis model assessment 2 model); this relation was independent of age, BMI, blood pressure, wall mass, HDL cholesterol, triglycerides, smoking habits, and metabolic syndrome. CONCLUSIONS—Abnormal LV energy metabolism was detectable in obese men in the presence of normal function, supporting the hypothesis that metabolic remodeling in insulin resistant states precedes functional and structural/geometrical remodeling of the heart regardless of the onset of overt hyperglycemia.
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- 2007
244. Hepatic steatosis after islet transplantation: Can ultrasound predict the clinical outcome? A longitudinal study in 108 patients
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Lorenzo Piemonti, Paola Maffi, Paolo Fiorina, Giulia Querques, Massimo Venturini, Alessandro Del Maschio, Francesco De Cobelli, Giulia Agostini, Antonio Secchi, Sandro Sironi, Venturini, M, Maffi, P, Querques, G, Agostini, G, Piemonti, L, Sironi, S, De Cobelli, F, Fiorina, P, Secchi, A, Del Maschio, A, Querques, Giuseppe, Piemonti, Lorenzo, DE COBELLI, Francesco, Secchi, Antonio, DEL MASCHIO, Alessandro, and Pathology/molecular and cellular medicine
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Male ,Hepatic steatosis ,medicine.medical_treatment ,Islets of Langerhans Transplantation ,Hepatic steatosis, Islet transplantation, Pancreatogenic diabetes, Type 1 diabetes, Ultrasound, β-Score ,Gastroenterology ,chemistry.chemical_compound ,Insulin-Secreting Cells ,Prevalence ,Longitudinal Studies ,Islet transplantation ,geography.geographical_feature_category ,Fatty liver ,FATTY LIVER ,ultrasonography ,Middle Aged ,Islet ,Treatment Outcome ,Type 1 diabetes ,young adult ,Female ,Adult ,medicine.medical_specialty ,Pancreatogenic diabetes ,Ultrasound ,β-Score ,Pancreas transplantation ,liver ,Transplantation, Autologous ,Predictive Value of Tests ,Internal medicine ,Journal Article ,medicine ,Humans ,Aged ,Pharmacology ,geography ,business.industry ,medicine.disease ,Transplantation ,Pancreatic Function Tests ,Diabetes Mellitus, Type 1 ,Endocrinology ,chemistry ,Basal (medicine) ,Glycated hemoglobin ,Steatosis ,business - Abstract
Percutaneous intra-portal islet transplantation (PIPIT) is a less invasive, safer, and repeatable therapeutic option for brittle type 1 diabetes, compared to surgical pancreas transplantation. Hepatic steatosis is a consequence of the islet engraftment but it is curiously present in a limited number of patients and its meaning is controversial. The aims of this study were to assess hepatic steatosis at ultrasound (US) after PIPIT investigating its relationship with graft function and its role in predicting the clinical outcome. From 1996 to 2012, 108 patients underwent PIPIT: 83 type-1 diabetic patients underwent allotransplantation, 25 auto-transplantation. US was performed at baseline, 6, 12, and 24 months, recording steatosis prevalence, first detection, duration, and distribution. Contemporaneously, steatotic and non-steatotic patients were compared for the following parameters: infused islet mass, insulin independence rate, beta-score, C-peptide, glycated hemoglobin, exogenous insulin requirement, and fasting plasma glucose. Steatosis at US was detected in 21/108 patients, 20/83 allo-transplanted and 1/25 auto-transplanted, mostly at 6 and 12 months. Infused islet mass was significantly higher in steatotic than non-steatotic patients (IE/kg: S = 10.822; NS = 6138; p = 0.001). Metabolically, steatotic patients had worse basal conditions, but better islet function when steatosis was first detected, after which progressive islet exhaustion, along with steatosis disappearance, was observed. Conversely, in non-steatotic patients these parameters remained stable in time. Number of re-transplantations was significantly higher in steatotic than in non-steatotic patients (1.8 vs 1.1; p = 0.001). Steatosis at US seems to be related to the islet mass and local overworking activity. It precedes metabolic alterations and can predict graft dysfunction addressing to therapeutic decisions before islet exhaustion. If steatosis does not appear, no conclusion can be drawn. (C) 2015 Elsevier Ltd. All rights reserved.
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- 2015
245. Effects of short-term manipulation of serum FFA concentrations on left ventricular energy metabolism and function in patients with heart failure: no association with circulating bio-markers of inflammation
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Guido Lattuada, Antonio Esposito, Tamara Canu, A. Salerno, F. De Cobelli, Gianluca Perseghin, Gabriele Fragasso, A. Del Maschio, Alberto Margonato, Giuseppina Manzoni, Salerno, A, Fragasso, G, Esposito, Antonio, Canu, T, Lattuada, G, Manzoni, G, DEL MASCHIO, Alessandro, Margonato, Alberto, DE COBELLI, Francesco, Perseghin, G., Esposito, A, Del Maschio, A, Margonato, A, De Cobelli, F, and Perseghin, G
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Adult ,Male ,medicine.medical_specialty ,Acipimox ,Magnetic Resonance Spectroscopy ,Endocrinology, Diabetes and Metabolism ,Heart Ventricles ,Adipokine ,Biology ,Fatty Acids, Nonesterified ,Ventricular Function, Left ,Phosphocreatine ,chemistry.chemical_compound ,Endocrinology ,Blood serum ,Adipokines ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Insulin ,MED/13 - ENDOCRINOLOGIA ,Aged ,Hypolipidemic Agents ,Heart Failure ,Inflammation ,Ejection fraction ,Tumor Necrosis Factor-alpha ,Leptin ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,ATP ,chemistry ,Phosphorus-31 magnetic resonance spectroscopy ,Heart failure ,Pyrazines ,Resistin ,Energy Metabolism ,Biomarkers ,medicine.drug - Abstract
Background and aims: We wanted to assess the effects of short-term changes in serum free fatty acids (FFAs) on left ventricular (LV) energy metabolism and function in patients with heart failure and whether they correlated with circulating markers of inflammation. Methods and results: LV function and phosphocreatine (PCr)/ATP ratio were assessed using MR imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) in 11 men with chronic heart failure in two experimental conditions 7 days apart. Study 1: MRI and 31P-MRS were performed before and 3–4 h after i.v. bolus + continuous heparin infusion titrated to achieve a serum FFA concentration of 1.20 mM. Study 2: The same protocol was performed before and after the oral administration of acipimox titrated to achieve a serum FFA concentration of 0.20 mM. Serum concentrations of IL6, TNF-α, PAI-1, resistin, visfatin and leptin were simultaneously assessed. Serum glucose and insulin concentrations were not different between studies. The PCr/ATP ratio (percent change from baseline: +6.0 ± 16.9 and −16.6 ± 16.1 % in Study 1 and Study 2, respectively; p = 0.005) and the LV ejection fraction (−1.5 ± 4.0 and −6.9 ± 6.3 % in Study 1 and Study 2, respectively; p = 0.044) were reduced during low FFA when compared to high FFA. Serum resistin was higher during Study 1 than in Study 2 (p
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- 2015
246. Cardiac Computed Tomography in Troponin-Positive Chest Pain: Sometimes the Answer Lies in the Late Iodine Enhancement or Extracellular Volume Fraction Map
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Antonio, Esposito, Anna, Palmisano, Maurizio, Barbera, Davide, Vignale, Giulia, Benedetti, Roberto, Spoladore, Marco Bruno, Ancona, Francesco, Giannini, Michele, Oppizzi, Alessandro, Del Maschio, and Francesco, De Cobelli
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Adult ,Aged, 80 and over ,Male ,Computed Tomography Angiography ,Myocardial Infarction ,Contrast Media ,Coronary Angiography ,Troponin ,Angina Pectoris ,Diagnosis, Differential ,Predictive Value of Tests ,Humans ,Female ,Acute Coronary Syndrome ,Biomarkers ,Aged - Published
- 2018
247. MP36-16 THE ROLE OF HISTOLOGIC SUBTYPES IN FOLLOW-UP SCHEME OF POSTSURGICAL KIDNEY CANCER PATIENTS
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Patrizio Rigatti, Alessandro Nini, Giorgio Gandaglia, Umberto Capitanio, Rayan Matloob, Alessandro Larcher, Roberto Bertini, Cristina Carenzi, Roberto Nicoletti, Alessandro Del Maschio, Walter Cazzaniga, Francesco Cianflone, Luigi Gianolli, Roberta Lucianò, Francesco Montorsi, Claudio Doglioni, Maria Picchio, Alberto Briganti, Andrea Salonia, Massimo Freschi, and Francesco De Cobelli
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Oncology ,medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,medicine ,business ,medicine.disease ,Kidney cancer - Published
- 2018
248. MP53-16 THE MORE YOU SEE, THE MORE YOU MISS: ASSOCIATION BETWEEN PI-RADS SCORE OF THE INDEX LESION AND MULTI-FOCAL, CLINICALLY SIGNIFICANT PROSTATE CANCER
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Armando Stabile, Paolo Dell'Oglio, Francesco De Cobelli, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Giorgio Brembilla, Giulia Cristel, Gianpiero Cardone, Federico Dehò, Andrea Losa, Nazareno Suardi, Tommaso Maga, Franco Gaboardi, Alessandro Del Maschio, Shahrokh F. Shariat, Francesco Montorsi, and Alberto Briganti
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Urology - Published
- 2018
249. Chapter 15. Neurobiology of bilingualism
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Nicola Del Maschio, Jubin Abutalebi, Maschio, Nicola Del, and Abutalebi, Jubin
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Cognitive science ,03 medical and health sciences ,0302 clinical medicine ,05 social sciences ,0501 psychology and cognitive sciences ,Psychology ,030217 neurology & neurosurgery ,050105 experimental psychology - Published
- 2018
250. Not All Multiparametric Magnetic Resonance Imaging–targeted Biopsies Are Equal: The Impact of the Type of Approach and Operator Expertise on the Detection of Clinically Significant Prostate Cancer
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Stabile, Dell'Oglio, Gandaglia, Fossati, Brembilla, Cristel, Deho', F, Scattoni, Maga, Losa, Gaboardi, Cardone, Esposito, Cobelli, De, Del, Maschio, Montorsi, Briganti, and A
- Published
- 2018
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