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Could early tumour volume changes assessed on morphological MRI predict the response to chemoradiation therapy in locally-advanced rectal cancer?
- Source :
- Clinical radiology. 73(6)
- Publication Year :
- 2017
-
Abstract
- Aim: To investigate the potential role of an additional magnetic resonance imaging (MRI) examination performed during neoadjuvant chemoradiation therapy (CRT) in the prediction of pathological response in locally advanced rectal cancer (LARC). Material and methods: Forty-eight consecutive patients with LARC underwent neoadjuvant CRT. MRI studies at 1.5 T, including high-resolution T2-weighted sequences that were acquired parallel and perpendicular to the main axis of the tumour were performed before (preMRI), during (midMRI), and 6-8 weeks after the end of CRT (postMRI). Cancer volumes (Vpre, Vmid, Vpost) were drawn manually and the reduction rate calculated (ÎVmid, ÎVpost). According to Rödel's pathological tumour regression grade (TRG), patients were considered non-responders (NR; TRG0-2), partial responders (PR; TRG3), and complete responders (CR; TRG4). Multivariate regression analysis was performed to identify the best MRI predictors of NR, PR, and CR. Results: Twenty-five patients were considered PR (52%), 13 CR (27%), and 10 NR (22%). Tumour shrinkage mainly occurred shortly after CRT (ÎVmid: CR: 80±10% versus PR: 56±19% versus NR: 28±22%, p=2.2Ã10-16). Vmid, Vpost, ÎVmid, and ÎVpostcorrelated with TRG (p
- Subjects :
- Adult
Male
Radiology, Nuclear Medicine and Imaging
Colorectal cancer
Adenocarcinoma
Drug Administration Schedule
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
Prospective cohort study
Aged
medicine.diagnostic_test
business.industry
Rectal Neoplasms
Cancer
Magnetic resonance imaging
General Medicine
Chemoradiotherapy, Adjuvant
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Oxaliplatin
Tumor Burden
Treatment Outcome
Fluorouracil
030220 oncology & carcinogenesis
Female
Nuclear medicine
business
Chemoradiotherapy
medicine.drug
Subjects
Details
- ISSN :
- 1365229X
- Volume :
- 73
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical radiology
- Accession number :
- edsair.doi.dedup.....8920dac8226f77bd5b433466165bdf70