151. 葛根中内源性组分葛根素的生物效应.
- Author
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郭 娴, 郭 岚, 徐梦佳, 陈锦萍, and 万益群
- Subjects
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LACTATE dehydrogenase , *ISOFLAVONES , *BODY weight , *CONTROL groups , *MICE , *UREA , *HEART - Abstract
The biological effects of puerarin, the main endogenous component in Radix Puerariae, were explored to provide a scientific basis for the safe use of Radix Puerariae.Twenty Balb/C healthy mice were randomly divided into two groups according to body weight, namely the control group and the medication group,with 10 mice in each group,half male and half female.The mice in the medication group were intragastrically administrated with puerarin at a dose of 6000 mg• kg-1 once,and the mice in the control group were intragastrically administrated with PEG 400 in the same volume.After 7 days of continuous observation, the general activity status, body weight and death of mice were recorded daily. Seven days later, the mice were sacrificed after blood was taken from the orbital vein. The heart, liver and kidney of the mice were anatomically observed and HE staining was performed for histopathological study. The results showed that there was no significant difference in the body weight change and heart, liver and kidney indexes between the male and female puerarin mice and the control group CP>0.05).Serum urea( UREA) level in puerarin group was significantly higher than that in control group (P<0.05); The levels of lactate dehydrogenase(LDH) in serum of male and female mice and hydroxybutyrate dehydrogenase(HBDH) in serum of male rats in puerarin group were significantly lower than those in the control group (P<0.05). His topathological studies showed that puerarin had little effect on the liver of mice,while myocardial dissolution and focal renal tubulointerstitial hemorrhage were observed in mice. [ABSTRACT FROM AUTHOR]
- Published
- 2022