Back to Search Start Over

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract.

Authors :
Aitbaba A
Kabdy H
Baslam A
Azraida H
Aboufatima R
El Yazouli L
Sokar Z
Garzoli S
Chait A
Source :
Chemistry & biodiversity [Chem Biodivers] 2024 May; Vol. 21 (5), pp. e202400228. Date of Electronic Publication: 2024 Apr 17.
Publication Year :
2024

Abstract

Marrubium vulgare L. (Lamiaceae) has a long history of use in traditional herbal medicine for the treatment of respiratory tract infections, inflammatory conditions, and pain. This study aimed to investigate the chemical composition, acute toxicity, and antinociceptive effects of the aqueous extract from M. vulgare leaves (AEMV). Antioxidant activity was evaluated using DPPH and reducing power assays. The chemical composition of AEMV was determined through LC-MS/MS, and the levels of total phenolics, flavonoids, and condensed tannins were quantified. Acute oral toxicity was assessed in male Swiss mice with a single oral dose of AEMV (1, 2, 5 g/kg). The analgesic impact was examined through writhing, hot plate, and formalin tests. Our findings not only confirmed the safety of the extract in animal models but also revealed significant antioxidant activity in AEMV. High-performance liquid chromatography (HPLC) analysis identified important bioactive compounds, with marrubiin being a major component. Furthermore, AEMV demonstrated robust antinociceptive properties in all conducted tests, highlighting its potential as a valuable natural source of bioactive compounds suitable for a wide range of therapeutic applications.<br /> (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)

Details

Language :
English
ISSN :
1612-1880
Volume :
21
Issue :
5
Database :
MEDLINE
Journal :
Chemistry & biodiversity
Publication Type :
Academic Journal
Accession number :
38613448
Full Text :
https://doi.org/10.1002/cbdv.202400228