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165. Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1

Author

Basso, Daniela, primary, Bozzato, Dania, additional, Padoan, Andrea, additional, Moz, Stefania, additional, Zambon, Carlo-Federico, additional, Fogar, Paola, additional, Greco, Eliana, additional, Scorzeto, Michele, additional, Simonato, Francesca, additional, Navaglia, Filippo, additional, Fassan, Matteo, additional, Pelloso, Michela, additional, Dupont, Sirio, additional, Pedrazzoli, Sergio, additional, Fassina, Ambrogio, additional, and Plebani, Mario, additional

Published
2014
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167. MMP9 and S100A9 expression in peripheral blood mononuclear cells (PBMC) are correlated with PDAC and with PDAC-associated diabetes mellitus

Author

Moz, Stefania, primary, Bozzato, Dania, additional, Zambon, Carlo Federico, additional, Fogar, Paola, additional, Pelloso, Michela, additional, Milanetto, Anna Caterina, additional, Padoan, Andrea, additional, Navaglia, Filippo, additional, Greco, Eliana, additional, Pasquali, Claudio, additional, Plebani, Mario, additional, and Basso, Daniela, additional

Published
2013
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168. Usefulness of MALDI-TOF/MS Identification of Low-MW Fragments in Sera for the Differential Diagnosis of Pancreatic Cancer

Author

Padoan, Andrea, primary, Seraglia, Roberta, additional, Basso, Daniela, additional, Fogar, Paola, additional, Sperti, Cosimo, additional, Moz, Stefania, additional, Greco, Eliana, additional, Marchet, Alberto, additional, de Manzoni, Giovanni, additional, Zambon, Carlo-Federico, additional, Navaglia, Filippo, additional, Cristadoro, Luigi, additional, Di Chiara, Alda, additional, Nitti, Donato, additional, Pedrazzoli, Sergio, additional, Pavanello, Girolamo, additional, and Plebani, Mario, additional

Published
2013
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169. Pancreatic cancer (PC)-derived soluble mediators induce dendritic cells (DCs) to acquire an immunesuppressive phenotype by downregulating CTLA4

Author

Gnatta, Elisa, primary, Fogar, Paola, additional, Aita, Ada, additional, Frasson, Chiara, additional, Teolato, Sara, additional, Facco, Monica, additional, Bozzato, Dania, additional, Greco, Eliana, additional, Padoan, Andrea, additional, Navaglia, Filippo, additional, Moz, Stefania, additional, Zambon, Carlo-Federico, additional, Semenzato, Giampietro, additional, Basso, Giuseppe, additional, Plebani, Mario, additional, and Basso, Daniela, additional

Published
2013
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170. Pancreatic Tumors and Immature Immunosuppressive Myeloid Cells in Blood and Spleen: Role of Inhibitory Co-Stimulatory Molecules PDL1 and CTLA4. An In Vivo and In Vitro Study

Author

Basso, Daniela, primary, Fogar, Paola, additional, Falconi, Massimo, additional, Fadi, Elisa, additional, Sperti, Cosimo, additional, Frasson, Chiara, additional, Greco, Eliana, additional, Tamburrino, Domenico, additional, Teolato, Sara, additional, Moz, Stefania, additional, Bozzato, Dania, additional, Pelloso, Michela, additional, Padoan, Andrea, additional, De Franchis, Giuseppe, additional, Gnatta, Elisa, additional, Facco, Monica, additional, Zambon, Carlo-Federico, additional, Navaglia, Filippo, additional, Pasquali, Claudio, additional, Basso, Giuseppe, additional, Semenzato, Gianpietro, additional, Pedrazzoli, Sergio, additional, Pederzoli, Paolo, additional, and Plebani, Mario, additional

Published
2013
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171. Pancreatic Cancer Alters Human CD4+ T Lymphocyte Function

Author

Fogar, Paola, primary, Basso, Daniela, additional, Fadi, Elisa, additional, Greco, Eliana, additional, Pantano, Giorgia, additional, Padoan, Andrea, additional, Bozzato, Dania, additional, Facco, Monica, additional, Sanzari, Maria Colomba, additional, Teolato, Sara, additional, Zambon, Carlo-Federico, additional, Navaglia, Filippo, additional, Semenzato, Gianpietro, additional, Pedrazzoli, Sergio, additional, and Plebani, Mario, additional

Published
2011
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174. Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N‐terminal peptide (NT‐S100A8)

Author

Basso, Daniela, primary, Greco, Eliana, additional, Padoan, Andrea, additional, Fogar, Paola, additional, Scorzeto, Michele, additional, Fadi, Elisa, additional, Bozzato, Dania, additional, Moz, Stefania, additional, Navaglia, Filippo, additional, Zambon, Carlo‐Federico, additional, Seraglia, Roberta, additional, De Carlo, Eugenio, additional, Valerio, Anna, additional, Reggiani, Carlo, additional, Pedrazzoli, Sergio, additional, and Plebani, Mario, additional

Published
2010
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178. Suicide Gene Therapy With the Yeast Fusion Gene Cytosine Deaminase/Uracil Phosphoribosyltransferase Is Not Enough for Pancreatic Cancer

Author

Fogar, Paola, primary, Navaglia, Filippo, additional, Basso, Daniela, additional, Greco, Eliana, additional, Zambon, Carlo-Federico, additional, Fadi, Elisa, additional, Falda, Alessandra, additional, Stranges, Alessia, additional, Vannozzi, Francesca, additional, Danesi, Romano, additional, Pedrazzoli, Sergio, additional, and Plebani, Mario, additional

Published
2007
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180. Gastropanel: A useful screening test in paediatric populations

Author

Guariso, Graziella, primary, Basso, Daniela, additional, Conte, Silvia, additional, Fasolo, Michela, additional, Tasinato, Adriano, additional, Navaglia, Filippo, additional, Fogar, Paola, additional, Zambon, Carlo-Federico, additional, Greco, Eliana, additional, Schiavon, Stefania, additional, and Plebani, Mario, additional

Published
2006
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181. Mitochondrial DNA D-Loop in Pancreatic Cancer

Author

Navaglia, Filippo, primary, Basso, Daniela, additional, Fogar, Paola, additional, Sperti, Cosimo, additional, Greco, Eliana, additional, Zambon, Carlo-Federico, additional, Stranges, Alessia, additional, Falda, Alessandra, additional, Pizzi, Sara, additional, Parenti, Anna, additional, Pedrazzoli, Sergio, additional, and Plebani, Mario, additional

Published
2006
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183. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms

Author

Zambon, Carlo-Federico, primary, Basso, Daniela, additional, Navaglia, Filippo, additional, Falda, Alessandra, additional, Belluco, Claudio, additional, Fogar, Paola, additional, Greco, Eliana, additional, Gallo, Nicoletta, additional, Farinati, Fabio, additional, Cardin, Romilda, additional, Rugge, Massimo, additional, Di Mario, Francesco, additional, and Plebani, Mario, additional

Published
2004
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184. Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transfer in Pancreatic Cancer Cell Lines: An Incomplete Antitumor Effect

Author

Greco, Eliana, primary, Fogar, Paola, additional, Basso, Daniela, additional, Stefani, Anna Lisa, additional, Navaglia, Filippo, additional, Zambon, Carlo-Federico, additional, Mazza, Saverio, additional, Gallo, Nicoletta, additional, Piva, Maria Grazia, additional, Scarpa, Aldo, additional, Pedrazzoli, Sergio, additional, and Plebani, Mario, additional

Published
2002
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185. A 2026 D peptide as the putative pancreatic cancer-associated diabetogenic factor

Author

Basso, Daniela, primary, Valerio, Anna, additional, Seraglia, Roberta, additional, Mazza, Saverio, additional, Greco, Eliana, additional, Zambon, Carlo-Federico, additional, Grazia Piva, Maria, additional, Gallo, Nicoletta, additional, Fogar, Paola, additional, Pedrazzoli, Sergio, additional, Tiengo, Antonio, additional, and Plebani, Mario, additional

Published
2001
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190. Pancreatic Cancer Alters Human CD4+ T Lymphocyte Function.

Author

Fogar, Paola, Basso, Daniela, Fadi, Elisa, Greco, Eliana, Pantano, Giorgia, Padoan, Andrea, Bozzato, Dania, Facco, Monica, Sanzari, Maria Colomba, Teolato, Sara, Zambon, Carlo-Federico, Navaglia, Filippo, Semenzato, Gianpietro, Pedrazzoli, Sergio, and Plebani, Mario

Published
2011
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191. Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8).

Author

Basso, Daniela, Greco, Eliana, Padoan, Andrea, Fogar, Paola, Scorzeto, Michele, Fadi, Elisa, Bozzato, Dania, Moz, Stefania, Navaglia, Filippo, Zambon, Carlo-Federico, Seraglia, Roberta, De Carlo, Eugenio, Valerio, Anna, Reggiani, Carlo, Pedrazzoli, Sergio, and Plebani, Mario

Subjects
PANCREATIC cancer, DIABETES, CELL lines, INSULIN receptors, CELL growth, PHOSPHORYLATION, ISLANDS of Langerhans tumors
Abstract

After isolating NT-S100A8 from pancreatic cancer (PC) tissue of diabetic patients, we verified whether this peptide alters PC cell growth and invasion and/or insulin release and [Ca] oscillations of insulin secreting cells and/or insulin signaling. BxPC3, Capan1, MiaPaCa2, Panc1 (PC cell lines) cell growth, and invasion were assessed in the absence or presence of 50, 200, and 500 nM NT-S100A8. In NT-S100A8 stimulated β-TC6 (insulinoma cell line) culture medium, insulin and [Ca] were measured at 2, 3, 5, 10, 15, 30, and 60 min, and [Ca] oscillations were monitored (epifluorescence) for 3 min. Five hundred nanomolars NT-S100A8 stimulated BxPC3 cell growth only and dose dependently reduced MiaPaCa2 and Panc1 invasion. Five hundred nanomolars NT-S100A8 induced a rapid insulin release and enhanced β-TC6 [Ca] oscillations after both one ( F = 6.05, P < 0.01) and 2 min ( F = 7.42, P < 0.01). In the presence of NT-S100A8, [Ca] in β-TC6 culture medium significantly decreased with respect to control cells ( F = 6.3, P < 0.01). NT-S100A8 did not counteract insulin induced phosphorylation of the insulin receptor, Akt and IκB-α, but it independently activated Akt and NF-κB signaling in PC cells. In conclusion, NT-S100A8 exerts a mild effect on PC cell growth, while it reduces PC cell invasion, possibly by Akt and NF-κB signaling, NT-S100A8 enhances [Ca] oscillations and insulin release, probably by inducing Ca influx from the extracellular space, but it does not interfere with insulin signaling. J. Cell. Physiol. 226: 456-468, 2011. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2011
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192. Non-invasive diagnosis of Helicobacter pylori infection: simplified 13C-urea breath test, stool antigen testing, or DNA PCR in human feces in a clinical laboratory setting?

Author

Zambon, Carlo-Federico, Basso, Daniela, Navaglia, Filippo, Mazza, Saverio, Razetti, Monica, Fogar, Paola, Greco, Eliana, Gallo, Nicoletta, Farinati, Fabio, Rugge, Massimo, and Plebani, Mario

Subjects
*HELICOBACTER pylori, *ANTIGENS, *DNA, *FECES
Abstract

Objectives: (1) To compare two stool antigen EIAs (HpSA, FemtoLab) and PCR of ureaseA and cagA in feces, with 13C-urea breath test (UBT). (2) To ascertain whether a simplified UBT (breath collection time = 10 min) is as reliable as the standard assay (30 min). Design and Methods: Helicobacter pylori status was recorded in Group 1 (n = 187) by UBT, H. pylori stool antigen, ureA and cagA PCR in feces. UBT with 10, 20 and 30 min sampling was performed in Group 2 patients (n = 283). Results: The sensitivity and specificity of HpSA, FemtoLab, and ureA were 67% and 99%, 90% and 96%, 35% and 98%, respectively. cagA results were positive in 16/48 H. pylori-positive, and in 5/100 H. pylori−negative patients. The results of UBT with a 10- and 30-min sampling strictly overlapped. Conclusion: UBT with 10 min breath collection and FemtoLab stool antigen assay are the most reliable non-invasive tests to diagnose H. pylori infection. [Copyright &y& Elsevier]

Published
2004
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193. Effect of cagA Status on the Sensitivity of Enzyme Immunoassay in DiagnosingHelicobacter pylori–Infected Children.

Author

Plebani, Mario, Guariso, Graziella, Fogar, Paola, Basso, Daniela, Gallo, Nicoletta, Zambon, Carlo Federico, Mozrzymas, Renata, Celadin, Marilena, and Zacchello, Franco

Subjects
HELICOBACTER pylori infections, DIAGNOSIS, IMMUNOASSAY
Abstract

Background. The aims of our study were twofold. First, we sought to evaluate in symptomatic children the influence of the Helicobacter pylori genotype on gastritis, abdominal pain, and circulating anti-H, pylori IgG antibodies (anti-H. pylori IgG) or pepsinogen A (PGA) and C (PGC). Additionally, we sought to assess anti-H, pylori IgG, PGA, and PGC patterns in a large cohort (N = 921) of asymptomatic children. Materials and Methods. In 183 symptomatic children, H. pylori infection and the presence of gastritis were evaluated by histology. In a subgroup of 20 H. pylori-positive children, the H. pylori genotype was evaluated also by polymerase chain reaction. Nine hundred and twenty-one asymptomatic children, aged 11 to 14 years, were studied by anti-H, pylori IgG, PGA, and PGC serum determination. Results. The infection was found in 33 of 183 symptomatic children; among the 20 H. pylori-positive children for which the H. pylori genotype was available, cagA was present or absent in equal percentages. H. pylori infection was associated with more severe gastritis and higher serum levels of anti-H, pylori IgG and PGC but not with abdominal pain. In infected children, higher levels of anti-H, pylori IgG and the presence of abdominal pain were associated with infections caused by cagA-positive strains. In the cohort of 921 asymptomatic children, raised levels of anti-H, pylori IgG, PGA, and PGC were found in approximately 5% of the cases. Conclusions. Infection with cagA-positive H. pylori strains can be associated with increased frequency of reported abdominal pain and higher circulating levels of anti-H, pylori IgG. The serological assessment of H. pylori IgG using H. pylori antigens containing significant amounts of cagA protein may, therefore, underestimate the true prevalence of infection. [ABSTRACT FROM AUTHOR]

Published
1999
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194. Pancreatic Cancer Alters Human CD4+T Lymphocyte Function

Author

Fogar, Paola, Basso, Daniela, Fadi, Elisa, Greco, Eliana, Pantano, Giorgia, Padoan, Andrea, Bozzato, Dania, Facco, Monica, Sanzari, Maria Colomba, Teolato, Sara, Zambon, Carlo-Federico, Navaglia, Filippo, Semenzato, Gianpietro, Pedrazzoli, Sergio, and Plebani, Mario

Abstract

To verify whether the dysregulation of CD4+T cells concurs in worsening the outcome of pancreatic cancer, we compared the effects of pancreatic cancer and other gastrointestinal cancer cell-conditioned media on the (1) proliferation, migration, and differentiation of CD4+T cells and (2) expansion of CD4+memory (CD45RO), naive (CD45RA), activated (CD69), and regulatory (CD25) subsets.

Published
2011
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195. Analogs of Vitamin E Epitomized by -Tocopheryl Succinate for Pancreatic Cancer Treatment

Author

Greco, Eliana, Basso, Daniela, Fadi, Elisa, Padoan, Andrea, Fogar, Paola, Zambon, Carlo-Federico, Navaglia, Filippo, Bozzato, Dania, Moz, Stefania, Pedrazzoli, Sergio, and Plebani, Mario

Abstract

-Tocopheryl succinate (-TOS) is thought to be toxic only for cancer cells. We ascertained in vitro -TOS effects on pancreatic cancer (PC) and normal cell growth and verified whether the combination of nontoxic -TOS and 5-fluorouracil (5-FU) doses causes cancer cell death and whether -TOS effects are mediated by the proapoptotic proteins Bax/Bak and/or SMAD4/DPC4status.

Published
2010
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196. Suicide Gene Therapy With the Yeast Fusion Gene Cytosine Deaminase/Uracil PhosphoribosyltransferaseIs Not Enough for Pancreatic Cancer

Author

Fogar, Paola, Navaglia, Filippo, Basso, Daniela, Greco, Eliana, Zambon, Carlo-Federico, Fadi, Elisa, Falda, Alessandra, Stranges, Alessia, Vannozzi, Francesca, Danesi, Romano, Pedrazzoli, Sergio, and Plebani, Mario

Abstract

Suicide gene therapy with FCY1gene, encoding cytosine deaminase (CD), together with FUR1, encoding uracil phosphoribosyltransferase (UPRT), has been proposed for pancreatic cancer therapy in vivo. We ascertained whether gene therapy with FCY1-FUR1is effective in killing pancreatic cancer cells after 5-fluorocytosine (5-FC) treatment.

Published
2007
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198. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Author

Mohelnikova Duchonova, Beatrice, Strouhal, Ondrej, Hughes, David, Holcatova, Ivana, Oliverius, Martin, Kala, Zdenek, Campa, Daniele, Rizzato, Cosmeri, Canzian, Federico, Pezzilli, Raffaele, Talar Wojnarowska, Renata, Malecka Panas, Ewa, Sperti, Cosimo, Zambon, Carlo Federico, Pedrazzoli, Sergio, Fogar, Paola, Milanetto, Anna, Capurso, Gabriele, DELLE FAVE, Gianfranco, Valente, Roberto, Gazouli, Maria, Malleo, Giuseppe, Lawlor, Rita Teresa, Strobel, Oliver, Hackert, Thilo, Giese, Nathalia, Vodicka, Pavel, Vodickova, Ludmila, Landi, Stefano, Tavano, Francesca, Gioffreda, Domenica, Piepoli, Ada, Pazienza, Valerio, Mambrini, Andrea, Pedata, Mariangela, Cantore, Maurizio, Bambi, Franco, Ermini, Stefano, Funel, Niccola, and Soucek, Pavel

Subjects
cancer, pancreas, risk, polymorphisms, SLC22A3, survival

199. Challenges of Preimplantation Genetic Counselling in the Context of Cystic Fibrosis and Other CFTR-Related Disorders: A Monocentric Experience in a Cohort of 92 Couples.

Author

Sorrentino, Ugo, Menegazzo, Massimo, Gabbiato, Ilaria, Calosci, Davide, Zambon, Carlo Federico, and Zuccarello, Daniela

Subjects
*GENETIC counseling, *EXOCRINE glands, *CYSTIC fibrosis, *MEDICAL care, *GENETIC testing
Abstract

Cystic fibrosis is a highly prevalent genetic disorder caused by biallelic pathogenic variants in the CFTR gene, causing an altered function of the exocrine glands and a subsequent spectrum of hypofunctional and degenerative manifestations. The increasing availability of carrier screening programmes, the enhanced life expectancy of patients due to improved treatment and care strategies and the development of more precise and affordable molecular diagnostic tools have prompted a rise in demand of prenatal diagnosis procedures for at-risk couples, including Preimplantation Genetic Testing (PGT). However, challenges remain: heterogeneity among screening programmes, nuances of variant interpretation and availability of novel treatments demand a considerate and knowledgeable approach to genetic counselling. In this work, we retrospectively evaluated the molecular data of 92 unselected couples who received a diagnosis of CFTR-related status and were referred to the genetics clinic at the University Hospital of Padua for genetic counselling on eligibility for PGT. A total of 50 couples were considered eligible for the procedure based on risk of transmitting biallelic pathogenic variants. We report and discuss our experience with this case series in the context of the Italian medical care system and present an overview of the most relevant issues regarding genetic counselling for PGT in CFTR-related disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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200. MALDI-TOF peptidomic analysis of serum and post-prostatic massage urine specimens to identify prostate cancer biomarkers.

Author

Padoan, Andrea, Basso, Daniela, Zambon, Carlo-Federico, Prayer-Galetti, Tommaso, Arrigoni, Giorgio, Bozzato, Dania, Moz, Stefania, Zattoni, Filiberto, Bellocco, Rino, and Plebani, Mario

Subjects
MATRIX-assisted laser desorption-ionization, PROSTATE cancer prognosis, PROSTATE-specific antigen, DETECTION limit, URINE
Abstract

Background: Lower urinary tract symptoms (LUTS) and prostate specific antigen-based parameters seem to have only a limited utility for the differential diagnosis of prostate cancer (PCa). MALDI-TOF/MS peptidomic profiling could be a useful diagnostic tool for biomarker discovery, although reproducibility issues have limited its applicability until now. The current study aimed to evaluate a new MALDI-TOF/MS candidate biomarker. Methods: Within- and between-subject variability of MALDI-TOF/MS-based peptidomic urine and serum analyses were evaluated in 20 and 15 healthy donors, respectively. Normalizations and approaches for accounting below limit of detection (LOD) values were utilized to enhance reproducibility, while Monte Carlo experiments were performed to verify whether measurement error can be dealt with LOD data. Post-prostatic massage urine and serum samples from 148 LUTS patients were analysed using MALDI-TOF/MS. Regression-calibration and simulation and extrapolation methods were used to derive the unbiased association between peptidomic features and PCa. Results: Although the median normalized peptidomic variability was 24.9%, the within- and between-subject variability showed that median normalization, LOD adjustment, and log2 data transformation were the best combination in terms of reliability; in measurement error conditions, intraclass correlation coefficient was a reliable estimate when the LOD/2 was substituted for below LOD values. In the patients studied, 43 peptides were shared by the urine and serum, and several features were found to be associated with PCa. Only few serum features, however, show statistical significance after the multiple testing procedures were completed. Two serum fragmentation patterns corresponded to the complement C4-A. Conclusions: MALDI-TOF/MS serum peptidome profiling was more efficacious with respect to post-prostatic massage urine analysis in discriminating PCa. [ABSTRACT FROM AUTHOR]

Published
2018
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