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Based on the gale-concentration degree and gale-concentration period， the temporal and spatial distribution characteristics of gale frequency and its influence on sandstroms are analyzed with the observation gale and sandstroms data for the peiod from 1961 to 2015 from surface meteorological stations.The following conclusions were drawn： （1） There is a good positive correlation between the frequency of sandstroms weather and the frequency of gale weather.The interannual variation trend of sand and sandstroms weather in southern Xinjiang is basically the same as that of gale weather.The frequency of sandstroms decreased abruptly after 1979 and stabilized after 2000.（2） The duration of the gale season was relatively fixed （April-August）， and the frequency of gale in each month was more than 20， during the year， the gale weather occurred mainly between mid-late May and early June， and there is a tendency to appear in advance.（3） Northern Tarim Basin is the area with frequent gale， and the inter-annual changes in gale days are more intense.Southern Tarim Basin is a region with fewer gale， and the frequency of gale varies little from year to year.Among them， the northern part of the South Xinjiang Basin （Kashgar， northern Bayingolin Mongol Autonomous Prefecture） has more concentrated gale weather during the year， the gale season is shorter， and the outbreak period is after late May； the southern regions （Hotan， Kizilsu Kirghiz Autonomous Prefecture， etc.） have gale windy weather during the year The situation is more dispersed， the gale season is longer， and the outbreak period is mainly before mid-May.

Abstract Background Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model. Results Undernutrition in utero induced metabolic disorders of F1 females, which was transmitted to F2 females. The global methylation in oocytes of F1 exposed to undernutrition in utero was decreased compared with the control. KEGG analysis showed that genes with differential methylation regions (DMRs) in promoters were significantly enriched in metabolic pathways. The altered methylation of some DMRs in F1 oocytes located at the promoters of metabolic-related genes were partially observed in F2 tissues, and the expressions of these genes were also changed. Meanwhile, the abnormal DNA methylation of the validated DMRs in F1 oocytes was also observed in F2 oocytes. Conclusions These results indicate that DNA methylation may mediate the transgenerational inheritance of metabolic disorders induced by undernourishment in utero via female germline.

Abstract Background Group A streptococcus is human-restricted gram-positive pathogen, responsible for various clinical presentations from mild epidermis infections to life threatened invasive diseases. Under COVID-19 pandemic,. the characteristics of the epidemic strains of GAS could be different. Purpose To investigate epidemiological and molecular features of isolates from GAS infections among children in Beijing, China between January 2020 and December 2021. Antimicrobial susceptibility profiling was performed based on Cinical Laboratory Sandards Institute. Distribution of macrolide-resistance genes, emm types, and superantigens was examined by polymerase chain reaction. Results 114 GAS isolates were collected which were frequent resistance against erythromycin (94.74%), followed by clindamycin (92.98%), tetracycline (87.72%). Emm12 (46.49%), emm1 (25.44%) were dominant emm types. Distribution of ermB, ermA, and mefA gene was 93.85%, 2.63%, and 14.04%, respectively. Frequent superantigenes identified were smeZ (97.39%), speG (95.65%), and speC (92.17%). Emm1 strains possessed smeZ, ssa, and speC, while emm12 possessed smeZ, ssa, speG, and speC. Erythromycin resistance was predominantly mediated by ermB. Scarlet fever strains harbored smeZ (98.81%), speC (94.05%). Impetigo strains harbored smeZ (88.98%), ssa (88.89%), and speC (88.89%). Psoriasis strains harbored smeZ (100%). Conclusions Under COVID-19 pandemic, our collections of GAS infection cutaneous diseases decreased dramatically. Epidemiological analysis of GAS infections among children during COVID-19 pandemic was not significantly different from our previous study. There was a correlation among emm, superantigen gene and disease manifestations. Long-term surveillance and investigation of emm types and superantigens of GAS prevalence are imperative.

Abstract Background Common chronic infections induced low-grade inflammation has been correlated with atherosclerosis as supported by strong evidence. The balance between pro-and anti-inflammatory factors was exploited to elucidate the effects of chronic periodontitis on diabetes-associated atherosclerosis. Methods Study subjects encompassed 30 SPF male rats randomly divided into four groups: A group (NC), B group (T2DM), C group (CP), D group (DM + CP). After developing the model, blood samples were collected from the angular vein analyze serum APN, hs-CRP, and blood lipid. the carotid artery was isolated for HE staining. Result Compared with group A, the serum APN in group B, C and D decreased gradually with the progression of the disease. Serum hs-CRP in group B, C and D was significantly increased. At T3, T4 and T5 in group B, C and D, APN/hs-CRP significantly decreased. TC, LDL and TG significantly increased in group B, D; HDL significantly decreased in group C. Carotid artery HE staining showed: compared with group A, different degrees of endothelial defect, destruction of elastic fibers in the middle membrane, disorder of smooth muscle arrangement, and partial dissolution 、 fragmentation and Calcium salt deposition necrosis occurred in group B, C and D. Conclusion Enhanced systemic inflammation, decreased adiponectin level, and disorganized lipid metabolism with or without type 2 diabetes attributed to local inflammation of periodontitis can result in an imbalance of pro-inflammatory and anti-inflammatory effects. Therefore, it’s more meaningful to predict the progression of DAA with anti-inflammatory/pro-inflammatory variation.

Abstract Existing machine learning potentials for predicting phonon properties of crystals are typically limited on a material-to-material basis, primarily due to the exponential scaling of model complexity with the number of atomic species. We address this bottleneck with the developed Elemental Spatial Density Neural Network Force Field, namely Elemental-SDNNFF. The effectiveness and precision of our Elemental-SDNNFF approach are demonstrated on 11,866 full, half, and quaternary Heusler structures spanning 55 elements in the periodic table by prediction of complete phonon properties. Self-improvement schemes including active learning and data augmentation techniques provide an abundant 9.4 million atomic data for training. Deep insight into predicted ultralow lattice thermal conductivity (

Typically, Cu catalysts agglomerate under electrochemical conditions. Here, the authors report a coordination polymer catalyst with neighboring Cu sites which remain isolated and reduce CO2 to C2H4 with high selectivity and stability

Abstract Objective To investigate the predictive value of deep learning-based cardiac ultrasound flow imaging for hypertrophic cardiomyopathy (HCM) complicated by arrhythmias. Methods The clinical data of 158 patients with hypertrophic cardiomyopathy were retrospectively collected from July 2019 to December 2021, and additionally divided into training group 106 cases, validation group 26 cases and test group 26 cases according to the ratio of 4:1:1, and divided into concurrent and non-concurrent groups according to whether they were complicated by arrhythmia or not, respectively. General data of patients (age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR) were collected, a deep learning model for cardiac ultrasound flow imaging was established, and image data, LVEF, LAVI, E/e', vortex area change rate, circulation intensity change rate, mean blood flow velocity, and mean EL value were extracted. Results The differences in general data (age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR) between the three groups were not statistically significant, P > 0.05. The differences in age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR between the patients in the concurrent and non-concurrent groups in the training group were not statistically significant, P > 0.05. Conclusions Deep learning-based cardiac ultrasound flow imaging can identify cardiac ultrasound images more accurately and has a high predictive value for arrhythmias complicating hypertrophic cardiomyopathy, and vortex area change rate, circulation intensity change rate, mean flow velocity, mean EL, LAVI, and E/e' are all risk factors for arrhythmias complicating hypertrophic cardiomyopathy.

[Introduction] The present, design and construction technology of suction bucket foundation is not mature, and there is lack of the normative guidance documents, the special research on the key technology of the construction process control of the suction bucket was implemented. [Method] Taking an offshore wind farm project as the background, based on the measured data of orientation platform foundations, statistical analysis, data mining, process back in the inversion method and technology was used. [Result] The constitution and function of the complete set of installation equipment of suction bucket foundation and the intelligent and digital control system are described in detail. The control parameters and control standards in the construction process of suction bucket foundation of guide frame platform are discussed. The feasibility analysis and calculation method and parameter value method of suction bucket penetration/jacking are summarized. The key points and control methods of each link in the whole process of suction bucket from penetration to jacking and recovery are put forward. [Conclusion] Finally, according to the measured construction data of seven four-pile guide frame platform suction bucket foundation, the variation characteristics of control parameters and the control effect during the construction of suction bucket foundation are illustrated. It can be used for reference in the design and construction of similar suction bucket platform foundation.

Based on the reanalysis data provided by the National Center for Environmental Prediction （NCEP）/National Center for Atmospheric Research （NCAR） and the monthly precipitation data provided by the Global Precipitation Climatology Center （GPCC） from 1961 to 2016， the relationships between the subtropical westerly jet and summer rainfall over central Asia were analyzed.The results show that when the subtropical westerly jet shifts south， the anomalous cyclone determines the central Asia， meantime the anomalous anticyclone over the Indian Peninsula and anomalous cyclone over central Asia transport the water vapor from the Arabian Sea into the central Asia， which cause more summer rainfall over central Asia， vice versa.The plateau monsoon over the TQinghai-Xizang Plateau and the surface sea temperature （SST） tropical Indian Ocean are well related to the jet position of subtropical westerly jet over central Asia.When positive anomalies of SST over whole tropical Indian Ocean， corresponding to weakened south Asian summer monsoon， it causes less rainfall and weakened latent heat over the Indian Peninsula.Based on the Gill atmospheric response， there is an anomalous cyclone over northwest flank of Indian Peninsula in upper troposphere， which causes the cooling of temperature in upper troposphere over central Asia； When the strengthened plateau monsoon over the Qinghai-Xizang Plateau， corresponding to more rainfall and strengthened latent heat， it causes an anomalous anticyclone over northwest flank of Qinghai-Xizang Plateau， which results in the cooling of temperature in upper troposphere over central Asia.Under the joint action of the plateau monsoon and SST over the Indian Ocean， the cooling of temperature in upper troposphere forms an anomalous cyclone in upper troposphere over central Asia， it causes more strengthened westerly at middle-low latitudes， corresponding to the jet shifting south， vice versa.

Abstract Background Research has indicated that the emergence of Schwann cells around premalignant lesions of colon cancer might be an early indicator promoting the onset of tumorigenesis. The present study explored the communication between colon cancer cells and Schwann cells. Methods Immunofluorescence analyses were conducted to examine the differential distribution of Schwann cells within colon cancer tissues and normal colon tissues. CCK8 assay, colony formation assay, wound healing assay, and transwell assay were performed to investigate the interaction between colon cancer cells and Schwann cells. Exosomes derived from colon cancer cells were isolated to further explore the effect of colon cancer cells on Schwann cells. Gain- and loss-of function experiments, luciferase reporter assays, chromatin immunoprecipitation assays, and immunohistochemistry assays were performed to reveal the cross-talk between colon cancer cells and Schwann cells. Furthermore, colon cancer cells co-cultured with Schwann cells were transplanted into nude mice for evaluating their effect on tumor proliferation and metastasis in vivo. Results The clinicopathological characteristics indicated that Schwann cells were enriched in colon cancer tissues and were associated with tumor metastasis and poor prognosis. The co-culture of Schwann cells with colon cancer cells promoted the proliferation and migration of colon cancer cells and Schwann cells, which was mediated by nerve growth factor (NGF) secreted from Schwann cells. Exosomal miR-21-5p released by colon cancer cells inhibited VHL expression in Schwann cells, which in turn stabilized the HIF-1α protein and increased the transcription of NGF. Meanwhile, the Schwann cells-derived NGF activated TrkA/ERK/ELK1/ZEB1 signaling pathway in colon cancer cells, which further enhanced the expression of exosomal miR-21-5p. Inhibition of either NGF or miR-21-5p significantly inhibited the proliferation and metastasis of transplanted colon cancer cells in nude mice. Coincidently, miR-21-5p was positively associated with the expression of NGF, p-ERK, p-ELK1, and ZEB1 in human colon cancer tissues. Conclusions Our results implicated a reciprocal communication between colon cancer cells and Schwan cells that promoted the proliferation and metastasis of colon cancer, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for the treatment of colon cancer.

Abstract The hetero-chitooligosaccharide (HTCOS) is a naturally occurring biopolymer in the exoskeleton of crustaceans and insects. Although some studies have been carried out on HTCOS in inducing plant resistance and promoting growth, the molecular mechanism of HTCOS in plants is not clear. In this study, an integrated analysis of metabolomics and transcriptomics was performed to analyze the response of Brassica napus to hetero-chitooligosaccharides treatment. The levels of 26 metabolites in B. napus were significantly changed under the HTCOS treatment. Amongst these metabolites, 9 metabolites were significantly up-regulated, including pentonic acid, indole-3-acetate, and γ-aminobutyric acid. Transcriptome data showed that there were 817 significantly up-regulated genes and 1064 significantly down-regulated genes in B. napus under the HTCOS treatment. Interestingly, the indole-3-acetate (IAA) content under the HTCOS treatment was about five times higher than that under the control condition. Moreover, four genes related to plant hormone signal transduction, three AUX/IAA genes, and one ARF gene, were significantly up-regulated under the HTCOS treatment. Furthermore, the plant height, branching number, and biomass of B. napus under the HTCOS treatment were significantly increased compared to that in the control condition. This evidence indicated that the HTCOS treatment contributed to accumulating the content of plant hormone IAA in the B. napus, up-regulating the expression of key genes in the signaling pathway of plant growth and improving the agronomic traits of B. napus.

Background Internal fixation for severe open articular bone defects is sometimes ineffective or dangerous. In the emergency stage, radical debridement and infection prevention are demanded to provide a good tissue base and the space‐occupying effect to provide enough necessary space to avoid soft‐tissue contraction for the reconstruction. In addition, the 3D printing technology makes individual limb reconstruction a reality. Case Presentation Here, we present a 31‐year‐old patient with an open fracture and severe bone defect of his left elbow caused by traffic accident, classified as Gustilo–Anderson IIIB. We adopted aggressive debridement and insertion of polymethyl methacrylate (PMMA) to prevent the infection and temporarily construct the bone defect in the emergency stage. Secondly, the total elbow arthroplasty was performed using a unique three‐dimensional (3D) printed prosthesis to reconstruct the elbow joint. During the follow‐up, the elbow movement function was satisfactory. Conclusions The modified Masquelet technique assisting 3D printing of personalized elbow joint makes the satisfactory functional reconstruction for open high‐energy injuries come true. It could be promoted for the similar surgery of other open joints fractures with severe bone defects.

The automatic P-wave onset time (P-onset) picking of microseismic (MS) waveforms generated during rock failure is the basis of and key to locating the source and exploring the failure mechanism of rock failure in underground engineering. However, it is hard to ensure the accuracy in picking P-onset of MS waveforms with a low signal-to-noise ratio (SNR) mixed with noises. Moreover, traditional P-onset picking methods mainly depend on manual intervention, which imposes onerous requirements on the SNR of MS waveforms. Hence, a new P-onset picking method is proposed based on the deep learning model: the principal components of MS waveforms are extracted based on the multi-channel singular spectrum analysis (MSSA) method to reduce the influence of noise; afterwards, a short-time Fourier transform (STFT) is applied to the processed MS waveforms to attain essential parameters of the waveforms; finally, a model for P-onset picking is established based on the long short-term memory (LSTM) network. Subsequently, a comparison is conducted between the proposed method and other methods based on actual field MS data collected from Xiadian Gold Mine and the seismic data from Stanford Earthquake Dataset. The results show that the proposed method can accurately extract data features of MS waveforms and further improve the P-onset picking performance.

Sand production is often characterized as a two-stage process, in which material failure occurs near the cavity, leading to the formation of a plastic zone, from which particles are detached and transported out because of continuous hydrodynamic erosion under the effects of the produced fluid flow. The plastic zone porosity is affected by coupled processes, while the plastic zone permeability has a significant impact on the performance of sand production prediction, especially in weak sandstone reservoirs. Large-scale sand production experiments were conducted using a customized high-pressure consolidation apparatus. The results show that specific stress-fluid pressure conditions may create a plastic zone around a hole, which has lower permeability than the intact zone. The plastic zone comprises two subzones: a high-permeability shear band zone and a low-permeability compaction zone. During sand production, sand migrates from the compaction zone through the shear band zone to the perforation hole. Thus, sand production is associated with the increased permeability and porosity in the compaction zone. Existing sand prediction models were modified according to the new findings, resulting in a modified model with improved performance. The modified model was validated using the sanding data from a weak sandstone reservoir in Kazakhstan.

Gully Stabilization and Highland Protection (GSHP) are useful in preventing gully erosion and have been widely utilized in the Loess Plateau of China. Groundwater rise is an important factor that can lead to loess-filled slope instability. A flume device was designed to study the process of water infiltration into a loess-filled slope and the subsequent failure process of the slope due to groundwater rise. The loess was uniformly infiltrated with water, resulting in preferential seepage via the development of cracks in the slope from settlement deformation. The pore-water pressure increased in the front of the slope and decreased at the back during slope failure, due to contraction in the slope toe and increased tensional at the back of the slope. The failure process of the slope can be divided into three stages, settlement deformation and collapse deformation with vertical displacement during slope settlement, and slope toe slide-flow or regressive failure with a primarily horizontal displacement in the direction of the slope’s free surface. The factors of suffusion erosion, saturated softening, and infiltration dynamics during water infiltration into the loess-filled slope promote slope failure according to experimental data and numerical simulations.

Hazardous microorganisms are an important factor for causing food quality and safety problems. Antibiotics effectively inhibit bacteria, and the resistance of microorganisms prevents them from being effectively controlled, which not only aggravate the food safety risks, but also cause serious economic losses. Hence, there is an urgent need to develop other alternative sterilization technologies. Photodynamic inactivation uses light to stimulate photosensitizer, which can produce reactive oxygen species. The morphological structure, cell membrane, nucleic acid and protein of pathogenic bacteria are destroyed by reactive oxygen species, leading to the death of bacteria. This mechanism triggers a variety of death mechanisms that bacteria are difficult to develop tolerance. Photodynamic inactivation achieves a good bactericidal effect. However, this sterilization technology pays less attention to the influence of food ingredients and quality, which limits its promotion and application in the food field. This review summarizes the mechanism and influencing factors of photodynamic inactivation. The application and research progress of photodynamic inactivation in the food industry are introduced, and new insights on the advantages and disadvantages of photodynamic inactivation in food applications are put forward, which aims to provide reference for the application of photodynamic inactivation in food industrial.

Abstract Breast cancer accounts for the largest number of patients among all cancers in the world. Intervention treatment for early breast cancer can dramatically extend a woman's 5‐year survival rate. However, the lack of public available breast mammography databases in the field of Computer‐aided Diagnosis and the insufficient feature extraction ability from breast mammography limit the diagnostic performance of breast cancer. In this paper, A novel classification algorithm based on Convolutional Neural Network (CNN) is proposed to improve the diagnostic performance for breast cancer on mammography. A multi‐view network is designed to extract the complementary information between the Craniocaudal (CC) and Mediolateral Oblique (MLO) mammographic views of a breast mass. For the different predictions of the features extracted from the CC view and MLO view of the same breast mass, the proposed algorithm forces the network to extract the consistent features from the two views by the cross‐entropy function with an added consistent penalty term. To exploit the discriminative features from the insufficient mammographic images, the authors learnt an encoder in the classification model to learn the invariable representations from the mammographic breast mass by Supervised Contrastive Learning (SCL) to weaken the side effect of colour jitter and illumination of mammographic breast mass on image quality degradation. The experimental results of all the classification algorithms mentioned in this paper on Digital Database for Screening Mammography (DDSM) illustrate that the proposed algorithm greatly improves the classification performance and diagnostic speed of mammographic breast mass, which is of great significance for breast cancer diagnosis.

Abstract Objective To compare the breakage risk of lengthened sacroiliac screws and ordinary sacroiliac screws to treat unilateral vertical sacral fractures and provide a reference for clinical application. Methods A finite element model of Tile C pelvic ring injury (unilateral type Denis II fracture of the sacrum) was produced. The sacral fractures were fixed with a lengthened sacroiliac screw and ordinary sacroiliac screw in 6 types of models. The maximal von Mises stresses and stress distributions of the two kinds of screws when standing on both feet were measured and compared. Results The maximal von Mises stress of the lengthened screw was less than that of the ordinary screw. Compared with ordinary screw, the stress distribution in the lengthened screw was more homogeneous. Conclusions The breakage risk of screws fixed in double segments is lower than that of screws fixed in single segments, the breakage risk of lengthened screws is lower than that of ordinary screws, and the breakage risk of screws fixed in S2 segments is lower than that of screws fixed in S1 segments.

Genome evolution of Allium genus and genomic basis underlying the pungency flavor formation remain poorly understood. Here, the authors assemble the genome of bunching onion and conduct population genetics analyses to reveal Allium genome evolution, flavor formation and domestication history.

Porphyra is an algae with important economic and research value in China. Its nutritional composition mainly contains polysaccharide, phycobiliprotein and active substances such as polyphenols, and has good antioxidant, antitumour, anti-cardiovascular disease and immunomodulatory effects. This review summarises the common extraction methods of nutrients such as polysaccharides, proteins and polyphenols from Porphyra and the latest research progress on bioactive functions such as antioxidant, antitumour and immune modulation under in vitro and in vivo models, which would provide reference for further high value development and utilization of Porphyra.

Abstract Aim The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of unstable atherosclerotic plaque using bioinformatics methods. Methods GSE120521, which includes four unstable samples and four stable atherosclerotic samples, was downloaded from the GEO database. DEGs were identified using LIMMA. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were performed using the Database for metascape Visualization online tool. Based on the STRING database, protein–protein interactions (PPIs) network among DEGs were constructed. Regulatory networks were visualized using Cytoscape. We use the xCell to analyze the different immune cell subtypes. Results A total of 1626 DEGs (1034 up-regulated and 592 down-regulated DEGs) were identified between unstable and stable samples. I pulled 62 transcription factors (34 up-regulated TFs and 28 down-regulated TFs) from the Trust database. The up-regulated TFs were mainly enrichment in positive regulation of myeloid leukocyte differentiation, and the down-regulated TFs were mainly enrichment in connective tissue development. In the PPI network, RB1, CEBPA, PPARG, BATF was the most significantly up-regulated gene in ruptured atherosclerotic samples. The immune cell composition enriched in CD cells and macrophages in the unstable carotid plaque. Conclusions Upregulated RB1, CEBPA, PPARG, BATF and down-regulated SRF, MYOCD, HEY2, GATA6 might perform critical promotional roles in atherosclerotic plaque rupture, furthermore, number and polarization of macrophages may play an important role in vulnerable plaques.

Abstract The stunning tails of comets are interesting astronomical phenomena to human beings and have been noticed for thousands of years. The bright tails also emit substantial materials into interplanetary space, including dusts and charged particles. The charged particles are picked up by solar wind magnetic fields, and thus could propagate together with solar wind to influence planetary space environments. Simultaneous measurements of comet materials, planetary space, and ground environments are crucial for understanding cometary impacts to planets, while such observations are quite rare. In this article, we present a full chain from the comet tail, to the solar wind cometary particles, and the impacts on the ground. Intense auroral events are observed when the cometary materials are observed in the Earthʼs upstream solar wind. Our results provide direct evidence that cometary ions could contribute substantial dynamic pressure in driving geomagnetic activities and the associated auroral intensifications.

Abstract Background & aims Aging is a pathophysiological process driven by a diverse set of complex biological processes, and environmental pollution plays an important role in this process. This study aimed to explore the association between serum α-Klotho levels and urinary perchlorate, nitrate, and thiocyanate levels. Methods This secondary dataset analysis included 4875 participants (mean age, 57.69 year; male, 49.58%; non-Hispanic White, 47.67%) from the US National Health and Nutrition Examination Survey (2007–2014). Enzyme-linked immunosorbent assay was used to quantify α-Klotho levels, and ion chromatography coupled with electrospray tandem mass spectrometry was used to quantify thiocyanate, nitrate, and perchlorate levels. Multivariate linear regression models were applied to estimate the association between perchlorate, nitrate, and thiocyanate levels and serum α-Klotho levels. Results Urinary thiocyanate levels were negatively associated with α-Klotho levels (β = − 0.006; 95% confidence interval, − 0.010 to − 0.003; P = 0.0004) after adjusting for age, sex, body mass index, race, alcohol consumption, estimated glomerular filtration rate, underlying disease, physical activity, smoking status, usual energy intake, and urinary creatinine and serum cotinine levels and mutual adjustment of urinary perchlorate, urinary nitrate, and urinary thiocyanate levels. The α-Klotho level in participants in the highest quartile was higher by 50.567 ng/mL (β = 50.567; 95% confidence interval, 14.407 to 86.726; P = 0.009) than that in participants in the lowest quartile of urinary perchlorate. A linear relationship was observed between urinary thiocyanate and α-Klotho levels. Conclusions Urinary thiocyanate levels were negatively associated with serum α-Klotho levels. Urinary thiocyanate should be further investigated as a potential mediator of aging and age-related diseases.

Abstract Background Previous clinical data have shown that raltegravir-based antiretroviral therapy (ART) with fewer drug-drug interactions (DDIs) and adverse events (AEs) is a good regimen in patients with HIV infection who need cancer chemotherapy. There are currently few data on ART regimens that include Integrase inhibitors (INSTIs) other than RAL among this patient subgroup. Methods We evaluated the safety and efficacy of different kinds of INSTI-based regimens among patients with HIV and concomitant colorectal cancer (CRC) who received antineoplastic agents. Results From January 2020 to November 2021, 66 patients were enrolled. The patients were divided into three groups: 20 patients treated with dolutegravir (DTG)/lamivudine (3TC)/tenofovir (TDF) (group I), 24 patients treated with DTG/albuvirtide (ABT) (group II), and 22 patients treated with bictegravir (BIC)/tenofovir alafenamide (TAF)/emtricitabine (FTC) (group III). The majority of AEs during treatment were of grade 1–2. Treatment‐related AEs of grade 3–4 occurred in 6 patients (9.09%), and no grade 5 AEs occurred. The most common AEs were nausea (100%) and neutrophils (84.85%) attributed to anticancer agents, and there was no significant difference in the incidence of these AEs among the three groups (P > 0.05). Viral load rebound was not observed among pretreated patients during chemotherapy. The viral load of untreated patients who started their ART concomitant with chemotherapy almost decreased to the lower limit of detection 6 months after ART initiation (only one patient in group III had a viral load of 102 copies/ml). At the 6th month, the CD4 count in group I decreased significantly from baseline (P

Abstract Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8+ T cells, is regulated by several intrinsic signaling pathways. Here, we found that tobacco smoke, a major public health concern that kills 8 million people each year worldwide, induced IDO1 in normal and malignant lung epithelial cells in vitro and in vivo. The carcinogen nicotine-derived nitrosaminoketone (NNK) was the tobacco compound that upregulated IDO1 via activation of the transcription factor c-Jun, which has a binding site for the IDO1 promoter. The NNK receptor α7 nicotinic acetylcholine receptor (α7nAChR) was required for NNK-induced c-Jun activation and IDO1 upregulation. In A/J mice, NNK reduced CD8+ T cells and increased Tregs. Clinically, smoker patients with non-small-cell lung cancer (NSCLC) exhibited high IDO1 levels and low Trp/kynurenine (Kyn) ratios. In NSCLC patients, smokers with lower IDO1 responded better to anti-PD1 antibody treatment than those with higher IDO1. These data indicate that tobacco smoke induces IDO1 to catabolize Trp metabolism and immune suppression to promote carcinogenesis, and lower IDO1 might be a potential biomarker for anti-PD1 antibodies in smoker patients, whereas IDO1-high smoker patients might benefit from IDO1 inhibitors in combination with anti-PD1 antibodies.

Establishing methods to access the chemical space that lies beyond canonical terpenoid biosynthesis will increase the applications of isoprenoids. Here, the authors reconstruct the modular structure of terpene biosynthesis on 16-carbon backbones by engineered yeast and synthesize 28 different unique terpenes.

SARS- CoV-2 hijacks ACE2 for cell entry. Here, the authors report that dynamic SUMOylation modulates the TOLLIP-directed selective autophagic degradation of ACE2 and suggest SUMOylation inhibition as a potential intervention against SARS-CoV-2 infection.

AimBreastfeeding generates short-term and long-term benefits for both mother and child. Exclusive breastfeeding (EBF) is promoted in China for years, but its practice still lags far behind the international average, even among low- and middle- income countries. This study aimed to investigate factors associated with EBF during postpartum.MethodsThis study was conducted in a tertiary referral hospital in Gansu Province, Northwest China from October 2019 to April 2020. 3,738 postnatal women were finally included and each of them completed an elaborately designed questionnaire. Infant feeding patterns (EBF or not) and reasons for NEBF (non-exclusive breastfeeding) were collected. The feeding knowledge score was based on 17 questions in relation to breastfeeding. The total score ranges from 0 to 17. Higher score means better understanding about breastfeeding knowledge. Multivariate logistic regression models were used to determine associated factors of EBF during postpartum. A subgroup analysis was conducted to investigate the association between feeding knowledge score and exclusive breastfeeding.ResultsSix weeks after childbirth, 1891 mothers (50.6%) maintained EBF. Among the NEBF mothers, 57.01% (n = 1,053) of them stopped exclusive breastfeeding due to self-perceived lack of breast milk production. Factors associated with NEBF were higher maternal age, ethnic minorities and cesarean section. Protective factors of EBF included multipara, positive feeding attitude and high breastfeeding knowledge score. In subgroup analysis, we found the breastfeeding knowledge score had a significant impact on the mothers of Han nationality, underwent cesarean or natural delivery, both primiparous and multiparous, and those with positive attitude towards breastfeeding (p

ABSTRACT Vibrio parahaemolyticus must endure various challenging circumstances while being swallowed by phagocytes of the innate immune system. Moreover, bacteria should recognize and react to environmental signals quickly in host cells. Two-component system (TCS) is an important way for bacteria to perceive external environmental signals and transmit them to the interior to trigger the associated regulatory mechanism. However, the regulatory function of V. parahaemolyticus TCS in innate immune cells is unclear. Here, the expression patterns of TCS in V. parahaemolyticus-infected THP-1 cell-derived macrophages at the early stage were studied for the first time. Based on protein-protein interaction network analysis, we mined and analyzed seven critical TCS genes with excellent research value in the V. parahaemolyticus regulating macrophages, as shown below. VP1503, VP1502, VPA0021, and VPA0182 could regulate the ATP-binding-cassette (ABC) transport system. VP1735, uvrY, and peuR might interact with thermostable hemolysin proteins, DNA cleavage-related proteins, and TonB-dependent siderophore enterobactin receptor, respectively, which may assist V. parahaemolyticus in infected macrophages. Subsequently, the potential immune escape pathways of V. parahaemolyticus regulating macrophages were explored by RNA-seq. The results showed that V. parahaemolyticus might infect macrophages by controlling apoptosis, actin cytoskeleton, and cytokines. In addition, we found that the TCS (peuS/R) could enhance the toxicity of V. parahaemolyticus to macrophages and might contribute to the activation of macrophage apoptosis. IMPORTANCE This study could offer crucial new insights into the pathogenicity of V. parahaemolyticus without tdh and trh genes. In addition, we also provided a novel direction of inquiry into the pathogenic mechanism of V. parahaemolyticus and suggested several TCS key genes that may assist V. parahaemolyticus in innate immune regulation and interaction.

The detection rate of Klebsiella pneumoniae in food is increasing, and it has emerged as a food pathogen. Global health is threatened due to the emergence of multidrug-resistant (MDR) and hypervirulent (hv) K. pneumoniae. Phages have a promising application as antibacterial agents and have the ability to lyse MDR strains. Hence, phage vB_KpP_HS106 against MDR-hv K. pneumoniae strains was isolated from sewage collected from a hospital. It can maintain stable activity at a pH range of 4–12 and a temperature range of 4°C to 50°C. The maximum adsorption rate of phage HS106 was found to be approximately 84.2% at 6 min. One-step growth curve analysis showed that the latent period of HS106 was 10 min and the burst size was approximately 183 PFU/cell. Furthermore, whole genome analysis indicated that the genome of phage HS106 was a double-stranded linear 76,430-bp long DNA molecule with 44% GC content. A total of 95 open reading frames were annotated in the HS106 genome, which did not contain any virulence genes or antibiotic resistance genes. Phage HS106 reduced MDR K. pneumoniae in milk by approximately 1.6 log10 CFU/mL at 25°C and in chicken by approximately 2 log10 CFU/cm3 at 25°C. Therefore, vB_KpP_HS106 is a promising alternative to antibiotics for biocontrol against multidrug-resistant K. pneumoniae in foods.

Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the majority of patients are currently unable to benefit from intravenous thrombolysis or intravascular mechanical thrombectomy due to the limited treatment windows and serious complications. Silent mating type information regulation 2 homolog 1 (Sirt1), a nicotine adenine dinucleotide-dependent enzyme, has emerged as a potential therapeutic target for ischemic stroke due to its ability to maintain brain homeostasis and possess neuroprotective properties in a variety of pathological conditions for the central nervous system. Animal and clinical studies have shown that activation of Sirt1 can lessen neurological deficits and reduce the infarcted volume, offering promise for the treatment of ischemic stroke. In this review, we summarized the direct evidence and related mechanisms of Sirt1 providing neuroprotection against cerebral ischemic stroke. Firstly, we introduced the protein structure, catalytic mechanism and specific location of Sirt1 in the central nervous system. Secondly, we list the activators and inhibitors of Sirt1, which are primarily divided into three categories: natural, synthetic and physiological. Finally, we reviewed the neuroprotective effects of Sirt1 in ischemic stroke and discussed the specific mechanisms, including reducing neurological deficits by inhibiting various programmed cell death such as pyroptosis, necroptosis, ferroptosis, and cuproptosis in the acute phase, as well as enhancing neurological repair by promoting angiogenesis and neurogenesis in the later stage. Our review aims to contribute to a deeper understanding of the critical role of Sirt1 in cerebral ischemic stroke and to offer novel therapeutic strategies for this condition.

Objectives Personal health literacy is the degree to which individuals have the ability to find, understand and use information and services to inform health-related decisions and actions for themselves and others. Health literacy levels remain low, despite the many measures that have been taken to improve it. In addition, the number of patients with chronic diseases is increasing. Our study aimed to explore the different aspects and factors influencing health literacy among patients with chronic diseases in Chongqing, China.Design Cross-sectional study.Setting and patients This study was conducted in Chongqing using the 2018 National Questionnaire on Health Literacy of Residents administered to 27 336 patients with chronic diseases.Outcome measures The prevalence and factors of health literacy in patients with chronic diseases.Results Among the patients who participated in the study (n=27 336), 51.3% were males. Only 21.6% of the patients with chronic diseases had adequate health literacy (questionnaire score was equal to or exceeded 80% of the total questionnaire score). Patients with chronic diseases aged 25–34 years (OR=1.18, 95% CI 1.02 to 1.36) and 35–44 years (OR=1.18, 95 % CI 1.03 to 1.35) had higher health literacy than patients aged 65–69 years. Patients from rural areas had higher health literacy levels than those from urban areas (OR=0.92, 95% CI 0.86 to 1.00). Furthermore, married patients had lower health literacy than unmarried patients (OR=0.88, 95% CI 0.80 to 0.97). Patients who were illiterate or slightly literate (OR=0.10, 95% CI 0.08 to 0.12) had lower health literacy than patients who were in junior college or had a bachelor’s degree or above. In addition, non-farmers had higher health literacy levels than farmers (OR=1.18, 95% CI 1.08 to 1.28). In terms of inadequate health literacy, patients who self-rated themselves as healthy had higher health literacy than those who self-rated as unhealthy (OR=1.80, 95% CI 1.33 to 2.43).Conclusions The health literacy of patients with chronic conditions remains at a low level and varies significantly with their demographic and social characteristics. These findings indicate that targeted interventions may be useful to improve health literacy in patients with chronic conditions in China.

Bearings are widely used in the industry due to their ability to support the movement of rotating bodies. The spacer rings are a key component of double-row roller bearings; therefore, the characteristics and properties of the spacer rings have a significant impact on the bearing functions. However, the lack of the characteristics and performance analysis of the spacer ring limits the improvement of bearing performance. To analyze the characteristics of spacer rings and establish a basis for improving their performance, a new testing method for the characteristics and performance of the spacer ring was presented and corresponding experiments were developed. The test procedure entails the evaluation of basic characteristics, surface properties, and serviceability. Basic characteristics were determined through element testing and cross-section morphological observation; surface properties were assessed through surface morphology and surface roughness detection; and serviceability was identified by cross-section hardness and frictional wear tests. The results show that the proposed test method can comprehensively characterize the performance of the spacer rings. The spacer ring composition mainly contains Fe, Al, P, Si, Ca, and S, which contribute to excellent wear resistance, hardness, strength, and corrosion resistance. The cross-sectional morphology exhibits porous characteristics, which enhance lubricity. In terms of surface property, the surface of the spacer ring is relatively flat, and the surface roughness is generally less than 0.6 μm Sa. The average friction coefficient is 0.85, and the friction and wear properties of the spacer ring are good. This study contributes to establishing the testing and evaluation criteria for the performance of spacer rings in engineering, which helps to improve the performance of bearings.

Water resources play a pivotal role in sustaining and shaping urban development. To assess the suitability of a site for urban construction, a water-resource–carrying capacity (WRCC) assessment is typically conducted. Here, we expand on the concept of the WRCC and construct an evaluation system based on the water quantity, quality, watershed and flow (WQQSF). Using this WQQSF evaluation system, we investigated the suitability of water resources for the development of the Xiong’an New Area (XNA) in China. Specifically, we evaluated the WRCC of XNA from 2010 to 2020 and identified the main obstacle factors. By building a system dynamics (SD) model, we analyzed projected changes in the carrying capacity of XNA from 2021 to 2035. The main findings were as follows:(1) the average WQQSF-index was 0.32 from 2010 to 2017, which corresponds to the overload condition, and rises to 0.41 from 2018 to 2020, which corresponds to the critical overload condition. (2) From the perspective of obstacle factors, the water quantity factor has a large influence on the water resources bearing condition of XNA accounting for about 40 %. (3) Considering that XNA is a water-scarce area, we should first ensure the balance between the supply and demand of water resources, and secondly, choose the optimal scenario for the carrying capacity. Among the five scenarios based on uncertainty, the S3 scenario not only meets the balance of water resources supply and demand but also has the best-carrying index, which is 0.7, showing a weak carrying condition. To ensure the sustainable development of WRCC in XNA, water conservation and strict control of population size should be adhered to in the future while increasing water recharge through multiple channels. This study provides a decision basis for the management, rational development, and allocation of WRCC in XNA.

Aerial recovery and redeployment can effectively increase the operating radius and the endurance of unmanned aerial vehicles (UAVs). However, the challenge lies in the effect of the aerodynamic force on the recovery system, and the existing road-based and sea-based UAV recovery methods are no longer applicable. Inspired by the predatory behavior of net-casting spiders, this study introduces a cable-driven parallel robot (CDPR) for UAV aerial recovery, which utilizes an end-effector camera to detect the UAV’s flight trajectory, and the CDPR dynamically adjusts its spatial position to intercept and recover the UAV. This paper establishes a comprehensive cable model, simultaneously considering the elasticity, mass, and aerodynamic force, and the static equilibrium equation for the CDPR is derived. The effects of the aerodynamic force and cable tension on the spatial configuration of the cable are analyzed. Numerical computations yield the CDPR’s end-effector position error and cable-driven power consumption at discrete spatial points, and the results show that the position error decreases but the power consumption increases with the increase in the cable tension lower limit (CTLL). To improve the comprehensive performance of the recovery system, a multi-objective optimization method is proposed, considering the error distribution, power consumption distribution, and safety distance. The optimized CTLL and interception space position coordinates are determined through simulation, and comparative analysis with the initial condition indicates an 83% reduction in error, a 62.3% decrease in power consumption, and a 1.2 m increase in safety distance. This paper proposes a new design for a UAV aerial recovery system, and the analysis lays the groundwork for future research.

Understanding developments in the trunk sap flow of prevalent tree species within the hilly areas of the Haihe River basin is imperative for ecosystem conservation. Nevertheless, the changes in sap flow of local trees and their response to environmental factors remain elusive. This study focuses on seven dominant tree species in the hilly area of the Haihe River basin and analyzed the relationship between tree sap flow rate and environmental factors at different time scales (hourly and daily). Our findings suggested: (1) Regardless of the time scale, total solar irradiance played a primary role in influencing sap flow rate. Conversely, as the time scale grew, the associations between most soil factors and sap flow rate enhanced, while those with meteorological factors declined. Notably, soil temperature exerted a more profound influence on sap flow rate than soil moisture and conductivity. (2) At the hourly scale, the sap flow rate of each species had a lag effect of 1–2 h with vapour pressure deficit, relative humidity and temperature, and 1 h or no lag effect with total solar irradiance and wind speed. (3) The response model of sap flow rate and environmental factors showed that, except for Pinus tabuliformis Carr., other tree species fit well at various time scales (R2 ≥ 0.59). As the time scale of most tree species increased from hourly scale to daily scale, the fit gradually weakened. Concurrently, considering the time-lag effect, the accuracy of the model has been improved, and the fitting accuracy of Koelreuteria paniculata Laxm. and Pinus tabuliformis Carr. has been significantly improved.

We developed the Stem Cell Educator therapy among multiple clinical trials based on the immune modulations of multipotent cord blood-derived stem cells (CB-SCs) on different compartments of immune cells, such as T cells and monocytes/macrophages, in type 1 diabetes and other autoimmune diseases. However, the effects of CB-SCs on the B cells remained unclear. To better understand the molecular mechanisms underlying the immune education of CB-SCs, we explored the modulations of CB-SCs on human B cells. CB-SCs were isolated from human cord blood units and confirmed by flow cytometry with different markers for their purity. B cells were purified by using anti-CD19 immunomagnetic beads from human peripheral blood mononuclear cells (PBMCs). Next, the activated B cells were treated in the presence or absence of coculture with CB-SCs for 7 days before undergoing flow cytometry analysis of phenotypic changes with different markers. Reverse transcription-polymerase chain reaction (RT-PCR) was utilized to evaluate the levels of galectin expressions on CB-SCs with or without treatment of activated B cells in order to find the key galectin that was contributing to the B-cell modulation. Flow cytometry demonstrated that the proliferation of activated B cells was markedly suppressed in the presence of CB-SCs, leading to the downregulation of immunoglobulin production from the activated B cells. Phenotypic analysis revealed that treatment with CB-SCs increased the percentage of IgD+CD27− naïve B cells, but decreased the percentage of IgD−CD27+ switched B cells. The transwell assay showed that the immune suppression of CB-SCs on B cells was dependent on the galectin-9 molecule, as confirmed by the blocking experiment with the anti-galectin-9 monoclonal antibody. Mechanistic studies demonstrated that both calcium levels of cytoplasm and mitochondria were downregulated after the treatment with CB-SCs, causing the decline in mitochondrial membrane potential in the activated B cells. Western blot exhibited that the levels of phosphorylated Akt and Erk1/2 signaling proteins in the activated B cells were also markedly reduced in the presence of CB-SCs. CB-SCs displayed multiple immune modulations on B cells through the galectin-9-mediated mechanism and calcium flux/Akt/Erk1/2 signaling pathways. The data advance our current understanding of the molecular mechanisms underlying the Stem Cell Educator therapy to treat autoimmune diseases in clinics.

The problems of gully and soil erosion caused by large-scale urban construction and agricultural development in China have become more and more serious in recent years. In an effort to solve this problem, a series of gully stabilization and highland protection projects have been carried out on the Loess Plateau, and this has resulted in a large number of high-loess-filled-slopes (HLFSs). Although these filled slopes uses several different mitigation measures, the HLFSs have been eroded and destroyed under the action of water. In order to study the influence of different mitigation measures on the stability of HLFSs and their failure process, this paper uses a flume test of the effects of various mitigation measures on this failure process. The results show that: (1) the failure processes of slopes with different mitigation measures are obviously different. Slope deformation u with a declining gradient mitigation mainly occurs on the surface of the slope body, and although slope erosion is quite serious, the slope does not fail as a whole. Slopes with a stepwise drainage channel mitigation show little erosion, but material can easily slide along the horizontal drainage channels. (2) The slope deformation process is correlated with changes in pore-water pressure. When local instability occurs, there is always a pre-process of continuously rising pore-water pressure. When a failure occurs, the pore-water pressure of the soil at each position of the slope body suddenly fluctuates under instantaneous excitation. (3) The response of soil pore pressure and the development characteristics of tension cracks affect the deformation of the slopes, which is also the cause of the differences slope instability caused by different mitigation measures. These research results provide reference for the protection of HLFS engineering projects from heavy rains.

Healthy eating is crucial for optimal growth, development, and the prevention of chronic diseases in adolescents. Our study aimed to develop a comprehensive structural equation model (SEM) to analyze the relationships between knowledge, attitudes, practices (KAP), and healthy eating among adolescents in Chongqing. An online questionnaire was administered to middle school students in 39 districts and counties of Chongqing, China from 2 December to 15 December 2021 to collect sociodemographic and KAP information. SEM models were constructed to examine the relationships between educational environment and healthy eating knowledge, attitudes, and practices. The Monte Carlo test was employed to assess the significance of the mediating effect of relevant variables. The study included 139,832 adolescents aged 14.8 ± 0.7 years, with a 14% rate of overweight and obesity. Health and nutrition knowledge averaged a score of 3.60 ± 1.50 (correct rate: 60%). Participants had positive attitudes (average score: 13.61 ± 2.29) and engaged in healthy eating practices (average score: 12.06 ± 3.08). The results of the SEM revealed a significant influence of the educational environment on adolescents’ knowledge (β = 0.235, p < 0.001) and attitude towards healthy eating (β = 0.143, p < 0.001). Knowledge exhibited positive effects on both attitude (β = 0.225, p < 0.001) and practice (β = 0.054, p < 0.001), while attitude exhibited positive effects on practice behavior (β = 0.565, p < 0.001). The indirect effect of knowledge on practices through attitude was more substantial than the direct effect (ratio 2.361). Our study highlights the mediating role of attitude between healthy eating knowledge and practices. A significant association exists between a favorable educational environment and improved knowledge and positive attitudes toward healthy eating among adolescents. In the future, nutrition and health education should prioritize exploring effective ways to translate knowledge into practices.

In previous work, we demonstrated that machine-learning techniques based on mixture density networks (MDNs) are successful in inferring the interior structure of rocky exoplanets with large compositional diversity. In this study, we compare the performance of a well-trained MDN model with the conventional Bayesian inversion method based on the Markov chain Monte Carlo (MCMC) method, under the same observable constraints. Considering that MCMC inversion is generally performed with the prior knowledge of planetary mass, radius, and bulk molar ratios of Fe/Mg and Si/Mg, we regenerate a substantial data set of interior structure data for rocky exoplanets and train a new MDN model with inputs of planetary mass, radius, Fe/Mg, and Si/Mg. It has been found that the well-trained MDN model has comparable performance to that of the MCMC method but requires significantly less computation time. The MDN model presents a practical alternative to the traditional MCMC method, surpassing the latter with minimal requirements for specialized knowledge, faster prediction, and greater adaptability. The developed MDN model is made publicly available on GitHub for the broader scientific community’s utilization. With the advent of the James Webb Space Telescope, we are ushering in a new epoch in exoplanetary explorations. In this evolving landscape, the MDN model stands out as a valuable asset, particularly for its ability to rapidly assimilate and interpret new data, thereby substantially advancing our understanding of the interior and habitability of exoplanetary systems.

Inter-basin water transfer (IBWT) projects are an effective means of addressing regional water resource imbalances. However, owing to the long construction cycle, large investment amount, and wide impact range, water diversion projects exhibit delayed and complex benefits, often lacking clear comprehension. In this study, we established a multi-regional comprehensive benefit assessment framework for the IBWT, considering spatiotemporal and multi-dimensional value effects. Using the South-to-North Water Diversion Project (SNWDP) in China as an example, we assessed its comprehensive benefits from 2003 to 2020. The results showed that the comprehensive benefits of the project were USD 207 billion, encompassing economic and ecological benefits, accounting for 71.6% and 28.4%, respectively. In 2020, the benefits of the SNWDP amounted to USD 39.3 billion, with a per-unit area benefit range of USD −1.03 to 4.27. The operation of the SNWDP effectively alleviated groundwater overexploitation in water-receiving areas. However, without the SNWDP, the total loss caused by industrial development limitations due to water scarcity would have been USD 154.3 billion. These results indicate the importance of a practical framework for assessing IWBT project benefits, aiding managers in assessment tasks, and facilitating the prediction and adjustment of project benefits.

The sap flow and transpiration of three typical tree species (poplar, locust tree, and willow) in Ningxia are crucial for sustaining the ecosystem in the Ningxia Yellow River Irrigation area. However, there is a lack of clarity regarding the variations in sap flow and transpiration of these trees and their corresponding responses to environmental factors. From February to December 2021, this study selected 30 samples representing the three typical trees in the irrigation area and monitored their tree sapwood sap flow continuously and dynamically using the Thermal Diffusion Probe method. This study yielded several key findings: (1) Variations exist in sap flow density and transpiration among the three typical trees, with willows exhibiting higher sap flow density and transpiration than poplars and locust trees. (2) Tree transpiration showed a highly significant positive correlation with net radiation, temperature, and vapor pressure deficit, along with a highly significant negative correlation with relative humidity. (3) Soil moisture content undergoes changes under precipitation and artificial drip irrigation, but its correlation with tree transpiration is limited. (4) The primary environmental factors influencing poplars, locust trees, and willows are temperature, soil moisture content at a depth of 30 cm, and soil moisture content at a depth of 60 cm.

This study on total suspended matter (TSM) in the Pearl River Estuary established a regression analysis model using Landsat 8 reflectance and measured TSM data, crucial for environmental management and engineering projects. High coefficients of determination (>0.6) were reported for the selected models. TSM concentration was notably high in 2013, peaking at 180 mg/L during the flood season and 80 mg/L in the dry season. In contrast, 2020 saw lower concentrations. Similar spatial distribution patterns were observed during dry and flood seasons, with high nearshore and low offshore TSM concentrations. Statistical analyses revealed natural factors (precipitation and runoff) as major influencers of the TSM distribution, with human activities presenting localized, limited impacts, except under long-term and large-scale conditions. Over time, the influence of large-scale water-based construction, such as the Hong Kong–Zhuhai–Macao Bridge, on TSM distribution became significant.

Ball-shell rotors with non-standard shapes, non-uniform conductive coatings, and eccentric masses machined by conventional processes constrain the improvement of levitation and torque accuracy of magnetically levitated momentum balls. This paper focuses on the machining method of multilayer ball-shell rotors to develop a ball-shell rotor with a standard shape and uniform conductive coating, which can improve the levitation and torque accuracy of magnetically levitated momentum balls. In this paper, a machining method for multi-coated ball-shell rotors is proposed. The machining process combining hemispherical surface and workpiece is adopted, and the whole sphere is assembled by threading, which effectively reduces the machining error. The influence of the cutting depth and feed rate of the tool on the cutting force of the ball shell was analyzed through the cutting force model. The effect of cutting force on the deformation of the ball shell was analyzed by the finite element method. The superiority of the machining method was verified by measuring the dimensions of the ball shell with a coordinate measuring machine. Compared with the traditional machining process and assembly method, the proposed ball-shell rotor machining method effectively improves the dimensional accuracy, reduces the center of mass to center of mass deviation, and ensures the levitation accuracy and output torque accuracy of the magnetically levitated momentum ball. Measurement results show that the diameter values of the pure iron ball shell are between 98.694 and 98.707 mm with a machining error of ±0.007 mm, and the diameter values of the spray-painted ball shell are between 99.490 and 99.510 mm with a machining error of ±0.01 mm. The machining static equilibrium of the pure iron ball shell and the spray-painted ball shell is good by the static equilibrium test method.

Restricted by the ill-posed antenna measurement matrix, the conventional smoothed L0 norm algorithm (SL0) fails to enable direct real aperture radar angular super-resolution imaging. This paper proposes a modified smoothed L0 norm (MSL0) algorithm to address this issue. First, as the pseudo-inverse of the ill-posed antenna measurement matrix is required to set the initial values and calculate the gradient projection, a regularization strategy is employed to relax the ill-posedness. Based on the regularization strategy, the proposed MSL0 algorithm can avoid noise amplification when faced with the ill-posed antenna measurement matrix of real aperture radar. Additionally, to prevent local minima problems, we introduce a hard thresholding operator, based on which the proposed MSL0 algorithm can accurately reconstruct sparse targets. Simulations and experimental results verify the performance of the proposed MSL0 algorithm.

Understanding the impact of irrigation on the spatiotemporal characteristics of precipitation is important for the ecological stability of the arid region of Northwest China (NWC). In this study, the global climate model MPI-ESM-MR is utilized to provide the initial and lateral boundary conditions for the regional climate model RegCM4, enabling the simulation of the long-term climate of the arid NWC region under two Representative Concentration Pathways (RCPs). The study focuses on analyzing the differences in the spatiotemporal distribution, intensity, and frequency of precipitation before and after irrigation. Furthermore, the study explores the primary factors influencing changes in the spatiotemporal distribution characteristics of precipitation in the irrigation district and its downwind region. The results indicate that RegCM4 performs well in simulating the climatology and diurnal cycle of precipitation in the NWC, particularly excelling during the summer. Large-scale irrigation significantly impacts the structure of summer precipitation, leading to a notable increase in convective precipitation near the irrigation district and surrounding mountain ranges. Anomalous cyclonic circulation and enhanced vertical velocity enhancement provide dynamic conditions for increased precipitation in the irrigation district and surrounding mountainous regions. Furthermore, the evaporation of water vapor resulting from large-scale irrigation serves as an additional source of moisture, contributing to increased precipitation in the irrigation district and its downwind region. Due to the difference in climatic conditions between the western and eastern regions around the irrigated areas, the summer extreme precipitation in the west predominantly increases. At the same time, in the east, it predominantly decreases due to irrigation. The findings of this study contribute to a deeper understanding of the physical mechanisms through which agricultural irrigation influences precipitation in the arid region of the NWC, thereby providing scientific evidence for the sustainable utilization of water resources in the region.

This study explores the full-field strain and dynamic fracture characteristics of a linear shaped charge under different initiation positions. The explosion dynamic caustic line experiment system is employed to examine the characteristics of the blast crack propagation of the linear shaped charge at different initiation positions and capture the dynamic information of the crack tip propagation speed and stress intensity factor. Furthermore, the digital image correlation method was used to show the strain evolution law of the linear shaped charge at different initiation positions, as well as the medium strain response of the charge near the explosion zone caused due to detonation transmission. The results show that in end-initiation, the wing crack length at the initiation point is the smallest, and the wing crack propagation length increases with the detonation propagation of the explosive. Conversely, in center-initiation, the propagation length of the wing cracks at the center is less than those at both ends. The propagation length of the wing cracks in the noninitiation end is the longest for end-initiation, where the velocities of the wing crack initiation and propagation are minimum. For center-initiation, the wing crack initiation and propagation velocities are the smallest, i.e., irrespective of the initiation position, the wing crack initiation and propagation velocities at the initiation point are lower than that at other locations. Based on the dynamic stress intensity factor analysis, irrespective of the initiation position, the center wing cracks are type Ⅰ cracks with the largest crack toughness, the stress intensity factor value is the maximum, and the wing cracks at the ends are type Ⅰ−Ⅱ composite cracks dominated by type Ⅱ. Based on the full-field strain analysis of the linear shaped charge, at end-initiation, the range of tension and strain action is mainly along the direction of explosive transmission, and the tension and strain action area at the noninitiation end is larger than that at the initiation end. The corresponding position of the maximum compressive strain is 0.67–0.83 times the charge length from the initiation point. When the center detonates, the action process of tension and compression strain propagates symmetrically from the center to both ends of the initiation, and the strain at the center is the largest. The compressive stress concentration at the end occurs under both initiation modes because the explosive transmission is the process of energy accumulation; thus, the effect of the explosive explosion on the medium grows increasingly stronger along the direction of explosive transmission.

Abstract Semiconductor device technology has greatly developed in complexity since discovering the bipolar transistor. In this work, we developed a computational pipeline to discover stable semiconductors by combining generative adversarial networks (GAN), classifiers, and high-throughput first-principles calculations. We used CubicGAN, a GAN-based algorithm for generating cubic materials and developed a classifier to screen the semiconductors and studied their stability using first principles. We found 12 stable AA $${}^{\prime}$$ ′ MH6 semiconductors in the F-43m space group including BaNaRhH6, BaSrZnH6, BaCsAlH6, SrTlIrH6, KNaNiH6, NaYRuH6, CsKSiH6, CaScMnH6, YZnMnH6, NaZrMnH6, AgZrMnH6, and ScZnMnH6. Previous research reported that five AA $${}^{\prime}$$ ′ IrH6 semiconductors with the same space group were synthesized. Our research shows that AA $${}^{\prime}$$ ′ MnH6 and NaYRuH6 semiconductors have considerably different properties compared to the rest of the AA $${}^{\prime}$$ ′ MH6 semiconductors. Based on the accurate hybrid functional calculations, AA $${}^{\prime}$$ ′ MH6 semiconductors are found to be wide-bandgap semiconductors. Moreover, BaSrZnH6 and KNaNiH6 are direct-bandgap semiconductors, whereas others exhibit indirect bandgaps.

Abstract Transverse-momentum-dependent parton distributions (TMDs) can be calculated from first principles by computing a related set of Euclidean lattice observables and connecting them via a factorization formula. This work focuses on the leading-power factorization formula connecting the lattice quasi-TMD and continuum Collins TMD for gluons. We calculate the one-loop gluon matching coefficient, which is known to be independent of spin and exhibits no mixing with quarks. We demonstrate that this coefficient satisfies Casimir scaling with respect to the quark matching coefficient at one-loop order. Our result facilitates reliable lattice QCD calculations of gluon TMDs.