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989 results on '"Utsumi, K"'

151. Antibodies to Cell Organoids in the Sera of Nasopharyngeal Carcinoma Patients and of Systemic Lupus Erythematosus Patients.

Author

Utsumi, K. R., Yoshida, T. O., Sekikawa, M., and Klein, G

Subjects
IMMUNOGLOBULINS, CANCER patients, LUPUS erythematosus, HUMAN embryos, LIVER, CELL lines
Abstract

The antinuclear antibody of nasopharyngeal cancer patients, of Taiwan and African origin, was examined by the indirect fluorescent antibody technique on various target cells: human embryonic cells, EL cells. Chang's liver cells, HeLa cells, I. cells, Chinese hamster kidney cells, and ral embryonic kidney cells. Sera of systemic lupus erythematosus patients, of Japanese origin, were also examined on the same cell lines for comparison with those of nasopharyngeal cancer patients. According to the various patterns of fluorescence observed, sera of nasopharyngeal cancer patients were supposed to contain several kinds of antibody to cell organoid(s), alone or in combination: nucleus, nucleolus. spindle fibers, substance(s) related to the spindle fibers, cetitriole, and the Golgi complex. None of these antibodies yielded fluorescence of chromosomes of metaphasic cells. Instead, speckled fluorescence observed in the interphase nucleus seemed to migrate into the cytoplasm at metaphase. Nuclear rim stain with a serum of systemic lupus erythematosus in the interphase nuclei seemed to be preserved in the rim stain of chromosomes at metaphase. [ABSTRACT FROM AUTHOR]

Published
1973
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156. Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells.

Author

Ajiro, K, Yoda, K, Utsumi, K, and Nishikawa, Y

Abstract

Effects of okadaic acid (OA), a protein phosphatase inhibitor, on chromatin structure and phosphorylation of histones were examined using HeLa and N18 cells. The chromatin condensation in HeLa cells was mild and resemble prometaphase nuclei, while the condensation in N18 cells was extensive and chromatin became a compact body. H2A in HeLa cells was extensively and consistently phosphorylated at the same site throughout the cell cycle, and H3 was demonstrated to be phosphorylated at the mitosis-specific site Ser10. In contrast, H1 phosphorylation was rapidly decreased in most sites within 3 h. The reduction of H1 phosphorylation was accompanied by a quantitative change in the set of H1 phosphopeptides. During the early phase of the OA treatment, H1 phosphorylation was transiently elevated in tandem, whereas H3 phosphorylation reached a maximum somewhat later. The results suggest that mitosis-specific events (cdc2/H1 kinase activation, H1 superphosphorylation, mitosis-specific H3 phosphorylation and chromatin condensation) induced by OA are sequentially associated. The changes appear to reflect a molecular mechanism similar to that operating in normal mitosis.

Published
1996

167. Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species

Author

Brosnan, C. F., Cannella, B., Battistini, L., Raine, C. S., Mosmann, T. R., Coffman, R. L., Selmaj, K., Benveniste, E. N., Hofman, F. M., Hanwehr, R. I., Dinarello, C. A., Woodroofe, M. N., Bellamy, A. S., Feldman, M., Cuzner, M. L., Hinton, D. R., Johnson, K., Merrill, J. E., Pober, J. S., Martiney, J. A., Litwak, M., Berman, J. W., Jacobs, C. A., Baker, P. E., Roux, E. R., Lee, S. C., Liu, W., Dickson, D. W., Hurwitz, A. A., Lyman, W. D., Guida, M. P., Schroeder, C. E., Ruddle, N. H., Bergman, C. M., Mcgrath, M. L., Cross, A. H., Barten, D. M., Traugott, U., Lebon, P., Merill, J. E., Simmons, R. D., Willenborg, D. O., Racke, M. K., Bonomo, A., Scott, D. E., Paul, W. E., Seder, R. A., Moore, K. W., Waal Malefyt, R., Abrams, J., Bennett, B., Fiorentino, D. F., Zlotnik, A., Oswald, I. P., Wynn, T. A., Sher, A., James, S. L., Kennedy, M. K., Torrance, D. S., Picha, K. S., Mohler, K. M., Chen, Y., Kuchroo, V. K., Inobe, J. -I, Bogdan, C., Paik, J., Vodovotz, Y., Nathan, C., Dubois, C. M., Ruscetti, F. W., Palaszynski, E. W., Gamble, J. R., Vadas, M. A., Dhib-Jalbut, S., Johns, L. D., Flanders, K. C., Ranhes, G. E., Sriram, S., Kuruvilla, A. P., Shah, R., Hochwald, G. M., Dinther-Janssen, A. C. H. M., Horst, R., Koopman, G., Zheng, Y. M., Schafer, E., Macmicking, J. D., Weidemann, M. J., Lin, R. F., Lin, T. S., Tilton, R. G., Misko, T. P., Murphy, S., Simmons, M. L., Agullo, L., Zembala, M., Maciej Siedlar, Marcinkiewicz, J., Pryjma, J., Tada, T., Ohzeki, S., and Utsumi, K.

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