Search

Copyright of Journal of Medical & Pharmaceutical Sciences is the property of Arab Journal of Sciences & Research Publishing (AJSRP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This present study is motivated by the United Nations Sustainable Development Goals (UN‐SDGs) that concerns pertinent issues that comprises environmental sustainability (SDG‐13), sustainable development (SGD‐8), and responsible consumption (SDG‐11), among others. To this end, this study examines the long‐run and causality linkage between renewable and non‐renewable energy, foreign direct investment, and economic globalisation in a carbon‐income framework by use of both carbon dioxide emission and ecological footprint as a determinant for environmental degradation for E7 countries. Furthermore, a series of panel econometrics panel tests in conjunction with quantile regression is used to explore the relationship between the outlined variables for annual frequency data from 1990 to 2016. Empirical results trace a long‐run equilibrium relationship among the highlighted variables as reported by Westerlund (2007). Additionally, this study gives credence and validates the pollution haven for the emerging (E7) countries examined, thus, implying the detrimental effect of foreign direct investment (FDI) on quality of environment in E7 economies. Interestingly, we observe that investment in renewable energy consumption will improve environmental quality. This outcome resonates with the advocacy of UN‐SDGs‐7, 11, 12, and 13, where emphasis is placed on responsible energy consumption (renewables), access to clean energy, and climate change mitigation. Conclusively, these revelations suggest the chase for adoption of low‐carbon development technologies and strategies in E7 countries. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of the study is to evaluate the effects of 0.01% atropine eye drops on accommodative system parameters among teenagers with low myopia. Methods: Ninety-five myopic teenagers [39 boys (8.69 ± 2.473) and 56 girls (8.54 ± 2.054) aged 5–17 years] with no history of eye disease were enrolled. Biometric and accommodative system parameters were evaluated before and at 1 week, 1 month, 3 months, and 6 months of 0.01% atropine eye drop instillation. Results: Participants without accommodative demand at 6 months demonstrated insignificant changes after the atropine instillation (all p > 0.05). Nevertheless, there were significant differences in accommodative sensitivity, accommodative amplitude, accommodative responsiveness, and negative relative accommodation (NRA) at 3 months compared with baseline after atropine instillation (all p < 0.05). Except spherical equivalent refraction, cornea thickness, intraocular pressure, and axial length were stable after the 0.01% atropine instillation (all p > 0.05). Conclusion: Morphologically, current measurements suggested that 0.01% atropine had favorable reduction of accommodation for childhood low myopia over a half-year period. [ABSTRACT FROM AUTHOR]

Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study ('IMAGINE') of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study ('Tayside') in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK). [ABSTRACT FROM AUTHOR]

Social cues, such as being watched, can subtly alter fund investment choices. This study aimed to investigate how cues of being watched influence decision-making, attention allocation, and risk tendencies. Using decision scenarios adopted from the "Asian Disease Problem," we examined participants' risk tendency in a financial scenario when they were watched. A total of 63 older and 66 younger adults participated. Eye tracking was used to reveal the decision-maker's attention allocation (fixations and dwell time per word). The results found that both younger and older adults tend to seek risk in the loss frame than in the gain frame (i.e., framing effect). Watching eyes tended to escalate reckless gambling behaviors among older adults, which led them to maintain their share in the depressed fund market, regardless of whether the options were gain or loss framed. The eye-tracking results revealed that older adults gave less attention to the sure option in the eye condition (i.e., fewer fixations and shorter dwell time). However, their attention was maintained on the gamble options. In comparison, images of "watching eyes" did not influence the risk seeking of younger adults but decreased their framing effect. Being watched can affect financial risk preference in decision-making. The exploration of the contextual sensitivity of being watched provides us with insight into developing decision aids to promote rational financial decision-making, such as human-robot interactions. Future research on age differences still requires further replication. [ABSTRACT FROM AUTHOR]

The effects of rewards on executive function (EF) reflect bidirectional interactions among motivational and executive systems that vary with age and temperament. However, methodological limitations hinder understanding of the precise influences of incentives on early EF, including the role of reward sensitivity. In this within‐subjects study, ninety‐three 3.5‐ to 5‐year‐olds (42 girls; 22% Hispanic; 78% White) residing in the United States completed equivalent EF measures (Stroop and non‐Stroop phases) in both rewarded and non‐rewarded conditions. Rewards enhanced Stroop accuracy and slowed overall response times (ds = 0.29–0.40). Critically, children with low parent‐reported reward sensitivity exhibited greater reward‐based increases in Stroop accuracy (r = −.30). These findings provide valuable insights on early motivation–cognition integration, highlighting temperament as a mechanism underlying these interactions. [ABSTRACT FROM AUTHOR]

Risk-taking behavior is particularly widespread during adolescence, and negatively impacts the healthy growth and social adaptation of adolescents. Utilizing problem-behavior theory (PBT) and the family stress model (FSM), the current study examined the relationship between socioeconomic status (SES) and adolescents' risk-taking behavior, as well as the mediating role of psychological capital and self-control. A total of 1,156 Chinese adolescent students (Mage = 15.51, 48% boys) completed a series of questionnaires anonymously. The results showed that: (1) Socioeconomic status was negatively correlated with adolescents' risk-taking behavior; (2) Both psychological capital and self-control mediated the relationship between SES and adolescents' risk-taking behavior independently; and (3) Psychological capital and self-control also mediated the relationship between SES and the risk-taking behavior of adolescents sequentially. This study reveals the internal mechanism of risk-taking behavior during adolescence and provides theoretical support and empirical evidence for preventing and reducing such behavior in this age group. [ABSTRACT FROM AUTHOR]

Solid waste management towards the sustainable process is one of the major undertakings of the Malaysia Solid Waste Management Department. Hence, development towards biofuels including biogas production from wastes has been escalating in Malaysia. There have been some major innovations in biogas production, including design and operation of the reactor, the presence of an additive, change in mixing regime, supporting unit, measurement, and monitoring systems, since the technology has developed. The sections mainly included are types of digesters, strategies such as upstream, mainstream, and downstream. In upstream strategies, the hydrothermal pretreatment of anaerobic digestion showed a higher improvement of biogas by an increase of 222 % of methane content. The mainstream strategies showed that co‐digestion was the best method to increase the methane yield to 305–445 mL g−1 VS. In downstream system, methane content can be upgraded from 60 to 90 % by applying water scrubber. This paper aims to discuss the recent trends and innovations in biogas production from waste and their pathways in details. [ABSTRACT FROM AUTHOR]

Research in the past decade has highlighted the nuances of adolescent decision making. In this review article, we summarize several themes evident in the field of developmental science including the redefinition of adolescence and the ways in which adolescent decision‐making capabilities converge with or diverge from those of adults. While the decision‐making process is similar for adolescents and adults in contexts that encourage deliberation and reflection, adolescents and adults differ in contexts which preclude deliberation vis‐à‐vis high emotional arousal. We also discuss the reconceptualization of adolescent behavior, including risk taking, as adaptive. That is, characteristics of adolescence, including impulsivity, the importance of peers, and novelty seeking, are normative, evolutionarily advantageous, and essential for positive development. While these features manifest in negative, health‐compromising ways (e.g., risky driving and criminal behavior), they also foster growth and exploration. We conclude with a discussion of potential avenues for future research. [ABSTRACT FROM AUTHOR]

Compelling evidence demonstrates that peer influence is a pervasive force during adolescence, one that shapes adaptive and maladaptive attitudes and behaviors. This literature review focuses on factors that make adolescence a period of special vulnerability to peer influence. Herein, we advance the Influence‐Compatibility Model, which integrates converging views about early adolescence as a period of increased conformity with evidence that peer influence functions to increase affiliate similarity. Together, these developmental forces smooth the establishment of friendships and integration into the peer group, promote interpersonal and intragroup compatibility, and eliminate differences that might result in social exclusion. [ABSTRACT FROM AUTHOR]

Objective: In contrast to the drug situation in the rest of the world, synthetic drugs, rather than traditional drugs, have been the dominant abused drugs in China since 2019. However, the public misconception that synthetic drugs are not as addictive as traditional drugs, such as opioids and the scarcity of specific measurement instruments, have hindered the clinical diagnosis and treatment of synthetic drug abusers, thus the development of a localized instrument to evaluate dependence on synthetic drugs is in urgently needed. Method: Using a sample of 618 Chinese synthetic drug abusers (Mean age = 34.69 years; 44.17% female), the present study developed and examined the psychometric properties of a self-reporting instrument, the Synthetic Drug Dependence Scale (SDDS), which consists of four subscales: physical dependence, psychological dependence, health injury, and social function injury. Results: The SDDS revealed a three-factor model structure (weighted root mean square residual (WRMR) = 0.876, comparative fit index (CFI) = 0.965, Tucker–Lewis index (TLI) = 0.953, and Root mean square error of approximation (RMSEA) = 0.070), with good internal consistency (composite reliability = 0.912, alfa = 0.801) and convergent validity. Elevated scores on the SDDS were associated with a higher level of reward sensitivity, punishment sensitivity, and stronger impulsivity. Interestingly, psychological dependence was the only significant predictor (p < 0.05) of criterion variables compared with the other three subscales, implying the important role of psychological factors in synthetic drugs dependence. Adequate measurement equivalence across sex, age (18–30 and 31–57 years old), and employment group (employed and unemployed) was also established. Conclusion: The SDDS appears to be an effective and reliable instrument that could be used to further investigate the characteristics of synthetic and traditional drug dependence, promoting a deeper understanding of the physical and psychological roles in drug dependence. [ABSTRACT FROM AUTHOR]

We do not know enough about the cognitive background of creativity despite its significance. Using an active oddball paradigm with unambiguous and ambiguous portrait paintings as the standard stimuli, our aim was to examine whether: creativity in the figural domain influences the perception of visual stimuli; any stages of visual processing; or if healthy aging has an effect on these processes. We investigated event related potentials (ERPs) and applied ERP decoding analyses in four groups: younger less creative; younger creative; older less creative; and older creative adults. The early visual processing did not differ between creativity groups. In the later ERP stages the amplitude for the creative compared with the less creative groups was larger between 300 and 500 ms. The stimuli types were clearly distinguishable: within the 300–500 ms range the amplitude was larger for ambiguous rather than unambiguous paintings, but this difference in the traditional ERP analysis was only observable in the younger, not elderly groups, who also had this difference when using decoding analysis. Our results could not prove that visual creativity influences the early stage of perception, but showed creativity had an effect on stimulus processing in the 300–500 ms range, in indexing differences in top-down control, and having more flexible cognitive control in the younger creative group. [ABSTRACT FROM AUTHOR]

Purpose: To assess neural changes in perceptual effects induced by myopic defocus and hyperopic defocus stimuli in ametropic and emmetropic subjects using functional magnetic resonance imaging (fMRI). Methods: This study included 41 subjects with a mean age of 26.0 ± 2.9 years. The mean spherical equivalence refraction was −0.54 ± 0.51D in the emmetropic group and −3.57 ± 2.27D in the ametropic group. The subjects were instructed to view through full refractive correction, with values of +2.00D to induce myopic defocus state and −2.00D to induce hyperopic defocus state. This was carried over in three random sessions. Arterial spin labeling (ASL) perfusion was measured using fMRI to obtain quantified regional cerebral blood flow (rCBF). Behavioral tests including distant visual acuity (VA) and contrast sensitivity (CS), were measured every 5 min for 30 min. Results: Myopic defocus induced significantly greater rCBF increase in four cerebral regions compared with full correction: right precentral gyrus, right superior temporal gyrus, left inferior parietal lobule, and left middle temporal gyrus (P < 0.001). The differences were less significant in low myopes than emmetropes. In the hyperopic defocus session, the increased responses of rCBF were only observed in the right and left precentral gyrus. Myopic defocused VA and CS improved significantly within 5 min and reached a plateau shortly after. Conclusion: This study revealed that myopic defocus stimuli can significantly increase blood perfusion in visual attention-related cerebral regions, which suggests a potential direction for future investigation on the relationship between retinal defocus and its neural consequences. [ABSTRACT FROM AUTHOR]

Over the last decade, research on cognitive control and decision‐making has revealed that individuals weigh the costs and benefits of engaging in or refraining from control and that whether and how they engage in these cost–benefit analyses may change across development and during healthy aging. In the present article, we examine how lifespan age differences in cognitive abilities affect the meta‐control of behavioral strategies across the lifespan and how motivation affects these trade‐offs. Based on accumulated evidence, we highlight two hypotheses that may explain the existing results better than current models. In contrast to previous theoretical accounts, we assume that age differences in the engagement in cost–benefit trade‐offs reflect a resource‐rational adaptation to internal and external constraints that arise across the lifespan. This article is categorized under:Psychology > Development and AgingPsychology > Reasoning and Decision Making [ABSTRACT FROM AUTHOR]

Nordic countries are part of the borderless Schengen Area, but free movement in the Nordic countries, or Norden, dates back even further: no border controls or restrictions on workers’ movements have existed since the entry into force of the Nordic labour market and passport union in 1958. This article outlines how Finland and its neighbour Sweden, the only Nordic country to keep borders open for Finland in 2020, approached closed borders in Norden during the Covid-19 pandemic, when free movement of Nordic citizens was suspended for the first time in almost 70 years, to be restored only in summer 2021. The article examines the Finnish and Swedish border practices and political debates. Parliamentary discourses are analysed from the perspective of two ideal types of argumentation, namely utilitarian and deontological, arguing that the suspension of free movement leaves long-lasting scars in the trust of both politicians and citizens in interaction across borders. [ABSTRACT FROM AUTHOR]

Objectives: This scoping review aims to explore and describe the barriers and enablers of low-vision rehabilitation service utilization among people 50 years or older in East and Southeast Asia., Introduction: Vision impairment is strongly associated with aging. East and Southeast Asia are experiencing a rapidly growing aging population and the associated eye-related health burdens. Despite the benefits of low-vision rehabilitation services, they are underutilized in these regions. Identifying the barriers and enablers of service utilization could be a crucial first step in making the services more accessible and, ultimately, easing the burden of this health issue., Inclusion Criteria: This review will include published quantitative, qualitative, or mixed methods studies and reviews that examine the barriers and/or enablers of low-vision rehabilitation service utilization among people aged 50 years or older living in East and Southeast Asia. Low-vision rehabilitation services are defined as any kind of intervention that aims to mitigate the impact of disability induced by eye-related health conditions., Methods: A literature search of 4 databases (MEDLINE, Web of Science, Academic Search Ultimate, and Ichushi-Web), as well as a manual search of the reference lists of included articles, will be conducted to identify eligible articles. Two independent reviewers will assess the articles for inclusion. Data extraction will focus on general information of the study, demographic or descriptive information about the study population, the eye condition being studied, means of low-vision rehabilitation, and the barriers and/or enablers of service utilization. The information will be tabulated to depict the categories of barriers and enablers that influence access to services., Review Registration: Open Science Framework https://osf.io/8y2wp., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 JBI.)

Environmental factors favoring myopia development are still being studied and there is accumulating evidence for a significant role of nearwork. Recently, reading standard black-on-white text was found to activate the retinal OFF pathway and induce choroidal thinning, which is associated with myopia onset. Contrarily, reading white-on-black text led to thicker choroids, being protective against myopia. Respective effects on retinal processing are yet unknown. Here, we exploratively assessed the impact of contrast polarity on the retinal activity and possible interactions with eccentricity and refractive error. We recorded pattern electroretinograms in myopic and emmetropic adults while presenting a dead leaves stimulus (DLS), overlaid by masks of different size in ring or circle shape, either filled with uniform gray or text of inverted or standard contrast. In myopes, retinal responses for DLS with standard and inverted contrast were larger when the perifovea was stimulated (6-12 deg), however, including the fovea resulted in smaller amplitudes for inverted contrast than in emmetropes. The retina of emmetropes was more sensitive to inverted contrast than to standard and gray within 12 deg, but most sensitive for gray in the perifovea. This demonstrates that the refractive error influences the sensitivity to text contrast polarity, with a special role of the peripheral retina, which is in line with previous studies about blur sensitivity. Defining whether the differences derive from retinal processing or anatomical features of a myopic eye requires further investigation. Our approach might be a first step to explain how nearwork promotes the eye's elongation., (© 2023. The Author(s).)

This study examined the development of prosocial charity donations and neural activity in the ventral striatum when gaining rewards for self and for charity. Participants 10-22 years (95% European heritage) participated in three annual behavioral-fMRI waves (T1: n = 160, T2: n = 167, T3: n = 175). Behaviorally, donations to charity as measured with an economic Dictator Game increased with age. Perspective taking also increased with age. In contrast, self-gain and charity-gain enjoyment decreased with age. Ventral striatum activity was higher for rewards for self than for charity, but this difference decreased during adolescence. Latent growth curve models revealed that higher donations were associated with a smaller difference between ventral striatum activation for self and charity. These findings show longitudinal brain-donations associations in adolescence., (© 2022 The Authors. Journal of Research on Adolescence published by Wiley Periodicals LLC on behalf of Society for Research on Adolescence.)

7-Ketocholesterol (7-KC), for example, is one of the major oxysterols present in human atherosclerotic lesions (Brown & Jessup, 1999), and especially enriched in cholesterol-filled macrophages where it impairs cholesterol efflux, driving the foam cell phenotype (Gelissen et al., 1996). This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. 2-Hydroxypropyl- -cyclodextrin reduces retinal cholesterol in wild-type and Cyp27a1 -/- Cyp46a1 -/- mice with deficiency in the oxysterol production. Cytoplasmic oxysterol-binding proteins: Sterol sensors or transporters?. [Extracted from the article]

aimed to investigate the surgical efficacy of staged posterior–anterior combined surgery for the treatment of cervicothoracic segmental tuberculosis (TB) with kyphosis in pediatric patients. Methods: The clinical data of 15 pediatric patients admitted to our hospital from January 2010 to December 2017 who underwent staged posterior–anterior combined surgery for cervicothoracic segmental TB with kyphosis were collected. A posterior median incision was made for patients after general anesthesia. Autologous bone particles or allogeneic bone particles were taken, trimmed, and placed in the articular eminence of the diseased vertebral body. Fifteen pediatric patients underwent second-stage lesion removal using the anterior approach. The left sternocleidomastoid muscle was selected as the medial oblique incision approach. The abscess and caseous necrotic material were removed and sent for pathological examination. The sagittal and coronal parameters (including the local Cobb angle, the sagittal vertical axis [SVA], and the coronal balance distance [CBD]) were measured at three time points: preoperatively, postoperatively, and at the final follow-up. The American Spinal Injury Association's spinal-cord injury classification, the Japanese Orthopaedic Association's (JOA) cervical spine function score, the neck disability index (NDI), and the visual analogue score (VAS) for cervicothoracic segment pain were adopted for the assessment of functional improvement and quality of life. Results: All 15 pediatric patients completed the surgery successfully, with an operation duration of 3.56 ± 0.68 h, an intraoperative hemorrhage of 289.7 ± 84.3 mL, an average fixation of 7.3 ± 1.8 segments, and a follow-up duration of 28.1 ± 9.7 months. The preoperative and postoperative sagittal local Cobb angle was 67.06 ± 17.54° vs 19.48 ± 2.32° (P < 0.01), the SVA was 35.19 ± 10.69 mm vs 7.67 ± 1.40 mm (P < 0.01), and CBD was 22.58 ± 7.59 mm vs 8.99 ± 1.25 mm (P < 0.01). The levels of the postoperative erythrocyte sedimentation rate and C-reactive protein were significantly lower in all patients. The preoperative and postoperative JOA scores were 8.93 ± 3.51 and 14.67 ± 1.34, respectively, the preoperative and postoperative VAS was 7.40 ± 1.35 and 2.67 ± 0.62, respectively, and the preoperative and postoperative NDI was 32.67 ± 4.83 and 13.73 ± 2.08, respectively. There were statistically significant differences in the above indicators before and after surgery (P < 0.05). Conclusion: In the surgical treatment of cervicothoracic TB with kyphosis in pediatric patients, staged posterior–anterior combined surgery significantly corrects deformity, achieves the safe and effective neurological decompression of the spinal cord, and obtains good neurological recovery and bone-graft fusion according to the extent of the involved segments of kyphosis, the characteristics of the lesion, and the degree of neurospinal injury. [ABSTRACT FROM AUTHOR]

Background: To assess the current myopia prevalence rate and evaluate the effect of sunshine duration on myopia among primary school students in the north and south of China. Methods: This prospective cross-sectional study pooled data from 9171 primary school students (grades from 1 to 6) from four cities in the north and south of China. National Geomatics Center of China (NGCC) and China Meteorological Administration provided data about altitude, latitude, longitude, average annual temperature, and average annual sunshine duration. Non-cycloplegic refraction was recorded, and prevalence rates in primary school students and factors associated with myopia were analyzed. Univariate and multivariate logistic regression models were used to determine the independent association of risk factors of myopia. Results: The overall myopia prevalence was 28.0%, from 7.5% to 50.6% for first and sixth grades, respectively. Low, moderate and high myopia significantly increased with school grades from 7.30% to 35.0%, 0.3% to 13.60% and 0.00% to 1.9%, respectively. Multiple regression analysis revealed that longer average cumulative daylight hours were connected to lower myopia prevalence in primary school students (OR, 0.721; 95% CI, [0.593– 0.877]; P=0.001), whereas girls and higher grade was independently associated with higher myopia prevalence (girls: β=0.189; OR, 1.208; 95% CI, [1.052– 1.387]; P=0.007; higher grade: β=0.502; OR, 1.652; 95% CI, [1.580– 1.726]; P< 0.001). Conclusion: This study demonstrated that myopia was highly prevalent in southern Chinese cities over northern ones, linked to shorter light exposure, higher education level, and female gender. Such findings reinforced the beneficial impact of daylight exposure with a protective role against myopia development. [ABSTRACT FROM AUTHOR]

Copyright of Der Ophthalmologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: To investigate whether the severity of symptoms of visual fatigue might be associated with clinical visual measures and basic visual functions, such as accommodation, vergence, and contrast sensitivity. Methods: In this study, 104 students were recruited (25 males, 79 females, Age 23.4 ± 2.5) for this study. Those with high myopia, strabismus, anisometropia, eye disease or history of ophthalmological surgery were excluded. The included subjects completed a questionnaire that assesses the severity of visual fatigue. Then, binocular accommodative facility, vergence facility and contrast sensitivity using a quick contrast sensitivity function approach were measured in a random sequence. Next, the correlations between each symptom of visual fatigue in the questionnaire and accommodative facility, vergence facility and contrast sensitivity were examined. Results: Factor analysis indicated that visual fatigue, as captured by the scores of a subset of the questionnaire items, could be strongly related to binocular accommodative facility and binocular contrast sensitivity, but not to vergence facility. We also found that binocular accommodative facility and contrast sensitivity at high spatial frequencies are related. Conclusion: Our findings suggest that visual fatigue is related to the ability of human observers to encode visual details through their binocular vision. [ABSTRACT FROM AUTHOR]

Background and Aims: Research shows that sensitivity to certain alcohol responses conveys risk for problem drinking. This study aimed to determine if high‐risk adolescent drinkers infuse more alcohol and experience greater alcohol‐induced stimulation and wanting and less sedation than low‐risk adolescent drinkers. Design and Participants: Ninety‐two low‐ (n = 38) and high‐risk (n = 54) adolescent drinkers, as determined by Alcohol Use Disorders Identification Test scores of < 6 or ≥ 6, respectively, participated in the Dresden Longitudinal Study on Alcohol Use in Young Adults in which intravenous alcohol self‐administration was examined in a mixed within‐ and between‐subjects design. Setting Technische Universität Dresden. Dresden, Germany. Measurements Predictors were drinking status (high‐ versus low‐risk), time and their interactions. Outcomes were arterial blood alcohol concentration (aBAC); alcohol‐induced stimulation, sedation and wanting assessed at baseline, 10 (alcohol prime), 45, 65, 85, 105, 125 and 145 minutes. Covariates were family history of alcohol use disorder, sex and aBAC. Results: The alcohol prime dose produced similar sharp increases in stimulation and sedation in high‐ and low‐risk drinkers (time P < 0.001; group × time P > 0.05). During self‐administration, high‐risk drinkers reached higher aBACs (P = 0.028) at a faster rate (group × time P < 0.001), and experienced further increases in stimulation (group × time P = 0.005) but with similar sedation (group × time P = 0.794) than in low‐risk drinkers. High‐risk drinkers also exhibited greater tonic alcohol wanting (group P = 0.003) throughout the session. Conclusions: High‐risk adolescent drinkers appear to have heightened sensitivity to alcohol‐induced stimulation and tonic high levels of wanting compared with low‐risk adolescent drinkers. [ABSTRACT FROM AUTHOR]

Background: Recent behavioural research has reported age‐related changes in the costs of refocusing attention from a temporal (rapid serial visual presentation) to a spatial (visual search) task. Using magnetoencephalography, we have now compared the neural signatures of attention refocusing between three age groups (19–30, 40–49 and 60+ years) and found differences in task‐related modulation and cortical localisation of alpha and theta oscillations. Efficient, faster refocusing in the youngest group compared to both middle age and older groups was reflected in parietal theta effects that were significantly reduced in the older groups. Residual parietal theta activity in older individuals was beneficial to attentional refocusing and could reflect preserved attention mechanisms. Slowed refocusing of attention, especially when a target required consolidation, in the older and middle‐aged adults was accompanied by a posterior theta deficit and increased recruitment of frontal (middle‐aged and older groups) and temporal (older group only) areas, demonstrating a posterior to anterior processing shift. Theta but not alpha modulation correlated with task performance, suggesting that older adults' stronger and more widely distributed alpha power modulation could reflect decreased neural precision or dedifferentiation but requires further investigation. Our results demonstrate that older adults present with different alpha and theta oscillatory signatures during attentional control, reflecting cognitive decline and, potentially, also different cognitive strategies in an attempt to compensate for decline. [ABSTRACT FROM AUTHOR]

This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography, autorefraction and HOA measurement. Contrast-sensitivity was tested using a psychophysical two-alternative forced-choice Gabor patches in three blocks (6, 9, 12 cycles/deg). Controls were compared to the keratoconus group and to a keratoconus subgroup with VA of 0.00 LogMar group ("keratoconus-0.00VA"). Spearman correlation tested association between HOA and contrast-sensitivity. Twenty-two keratoconus subjects (38 eyes: 28 keratoconus, 10 subclinical-keratoconus, 20 keratoconus-0.00VA) and 35 controls were included. There was a significant difference between control and keratoconus, and between control and keratoconus-0.00VA, for keratometry, cylinder, thinnest and central corneal thickness (p < 0.001). Controls showed lower HOA and higher contrast-sensitivity for all spatial-frequencies (p < 0.001). Most HOA were negatively correlated with contrast-sensitivity for all spatial-frequencies for keratoconus group and for 9 and 12 cycles/deg for keratoconus-0.00VA. Keratoconus subjects with good VA showed reduction in contrast-sensitivity and increased HOAs compared to controls. HOA and contrast-sensitivity are inversely correlated in subjects with mild keratoconus despite good VA. This suggests that the main mechanism underlying the decreased vision quality in keratoconus is the increase of HOA. [ABSTRACT FROM AUTHOR]

This study examines the impact of peers' previous cautious versus risky choices on adolescents' risk‐taking depending on the level of information about the risk. Adolescents completed an adaptation of the BART that manipulated social influence (cautious and risky) and risk information (i.e., informed, noninformed). Results showed that social influence impacts adolescents' decisions on the noninformed BART but not on the informed BART. In the noninformed BART, the peers' cautious choices strongly decreased risk‐taking and led to greater performance. The peers' risky choices increase adolescents' risk‐taking, but this effect is limited to situations involving minimal risk. Thus social experience may be a specific social context that represents a valuable source of information during adolescence, especially in situations with high uncertainty. [ABSTRACT FROM AUTHOR]

This work presents a hardware/software co-design implementation of the morphological reconstruction targeting a System-on-Chip (SoC) FPGA-based embedded system. Our approach processes large images with fast algorithms. This was achieved by the proposal and use of an execution scheme that partitions the input image into sub-images that are independently processed before a second phase is executed to enable propagation of information among sub-images. The SoC is efficiently used by processing sub-images on hardware (the costly phase), while the software takes care of computations due to discontinuities that are irregular and inefficient for the hardware execution. Several optimizations were proposed, including parallel software and hardware execution and the use of borders to minimize computations in the discontinuities correction. This enables the processing of large images from our use-case brain cancer tissue image analysis application. For an image of 8192 × 8192 pixels, our co-design solution attains a speedup of 12.7 × vs. the software execution (Dual core ARM A9 Cortex). [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effects of reading with mobile phone versus text on accommodation accuracy and near work-induced transient myopia (NITM) and its subsequent decay during near reading in young adults with mild to moderate myopia. Methods: The refractions of 31 young adults were measured with an open-field autorefractor (WAM-5500, Grand Seiko) for two reading tasks with a mobile phone and text at 33 cm. The mean age of the young adults was 24.35 ± 1.80 years. The baseline refractive aspects were determined clinically with full distance refractive correction in place. The initial NITM and its decay time and accommodative lag were assessed objectively immediately after binocularly viewing a mobile phone or text for 40 min. Results: The mean ± standard deviation (SD) initial NITM magnitude was greater for reading with text (0.23 ± 0.26 D) than for reading with mobile phone (0.12 ± 0.17 D), but there was no significant difference between the two reading tasks (p = 0.082). The decay time (median, first quartile, and third quartile) was 60 s (16, 154) and 70 s (32, 180) in the phone task and text task groups, respectively. There was also no significant difference in the decay time between the two reading types in general (p = 0.294). The accommodative lags of text tasks and mobile phones tasks were equivalent (1.27 ± 0.52 D vs 1.31 ± 0.64 D, p = 0.792). Conclusion: There were no significant differences in accommodative lags and the initial NITM and its decay time between reading with a mobile phone and text in young adults. [ABSTRACT FROM AUTHOR]

Purpose: To investigate changes in blur detection sensitivity in children using orthokeratology (Ortho-K) and explore the relationships between blur detection thresholds (BDTs) and aberrations and accommodative function. Methods: Thirty-two children aged 8–14 years old who underwent Ortho-K treatment participated in and completed this study. Their BDTs, aberrations, and accommodative responses (ARs) were measured before and after a month of Ortho-K treatment. A two forced-choice double-staircase procedure with varying extents of blur in three images (Tumbling Es, Lena, and Street View) was used to measure the BDTs. The participants were required to judge whether the images looked blurry. The BDT of each of the images (BDT_Es, BDT_Lena, and BDT_Street) was the average value of the last three reversals. The accommodative lag was quantified by the difference between the AR and the accommodative demand (AD). Changes in the BDTs, aberrations, and accommodative lags and their relationships were analyzed. Results: After a month of wearing Ortho-K lenses, the children's BDT_Es and BDT_Lena values decreased, the aberrations increased significantly (for all, P ≤0.050), and the accommodative lag decreased to a certain extent [T(31) = 2.029, P = 0.051]. Before Ortho-K treatment, higher-order aberrations (HOAs) were related to BDT_Lena (r = 0.463, P = 0.008) and the accommodative lag was related to BDT_Es (r = −0.356, P = −0.046). After one month, no significant correlations were found between the BDTs and aberrations or accommodative lags, as well as between the variations of them (for all, P ≥ 0.069). Conclusion: Ortho-K treatment increased the children's level of blur detection sensitivity, which may have contributed to their good visual acuity. [ABSTRACT FROM AUTHOR]

Mucosal surfaces of the upper respiratory tract and gut are physiologically colonized with their own collection of microbes, the microbiota. The normal upper respiratory tract and gut microbiota protects against pneumonia by impeding colonization by potentially pathogenic bacteria and by regulating immune responses. However, antimicrobial therapy and critical care procedures perturb the microbiota, thus compromising its function and predisposing to lung infections (pneumonia). Interindividual variations and age-related alterations in the microbiota also affect vulnerability to pneumonia. We discuss how the healthy microbiota protects against pneumonia and how host factors and medical interventions alter the microbiota, thus influencing susceptibility to pneumonia. [ABSTRACT FROM AUTHOR]

Copyright of Universitas Psychologica is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of IUG Journal of Educational & Psychological Studies is the property of Islamic University of Gaza and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Depression manifests in distinct ways across the life course. Recent research emphasizes how depression impedes development during emerging adulthood. However, our study—based on 40 interviews with emerging adults from multiple regions in the United States, analyzed following grounded theory—suggests a more complex narrative. Increasing experience with cycles of depression can also catalyze (a) mature perspectives and coping mechanisms that protect against depression's lowest lows; (b) deeper self-knowledge and direction, which in turn promoted a coherent personal identity; and (c) emergence of a life purpose, which fostered attainment of adult roles, skill development, greater life satisfaction, and enriched identity. Our synthesis reveals how depression during emerging adulthood can function at once as toxin, potential antidote, and nutritional supplement fostering healthy development. Our central finding that young adults adapt to rather than recover from depression can also enrich resilience theory, and inform both social discourse and clinical practice. [ABSTRACT FROM AUTHOR]

This study examined associations among adolescent risk preference and political engagement using nationally representative Monitoring the Future data from high school seniors (N = 109,574; modal age = 18 years) spanning 1976-2014. Greater risk preference was associated with greater past voting, donating to a campaign, writing government officials, boycotting, and protesting. Greater risk preference was also associated with higher future intentions to boycott and protest, but lower intentions to donate to or volunteer for a campaign. In general, associations between risk preference and political engagement became stronger with higher levels of political interest. Results highlight the importance of considering the adaptive role of adolescent risk preference and suggest that political engagement may be a constructive outlet for youth who pursue or are comfortable taking risks. [ABSTRACT FROM AUTHOR]

This paper explores how discourses of giftedness informed attitudes towards parenting in the United States from 1920 to 1960. Using psychologists' studies of giftedness, media coverage of the topic, and guidebooks for parents of gifted children, I argue that giftedness emerged in the 1910s, and by the 1920s addressed a newly limited definition of intelligence and problems in urban public education, coinciding with the popularity of the culture and personality school. Scholarly debates about giftedness traveled from the academy to the wider public through the media and guidebooks for parents. Media coverage brought awareness of the problem of the neglected gifted student, and guidebooks offered parents practical suggestions about how to raise gifted children. I show that the discourse contributed to racial segregation in American schools and classrooms by using merit to determine access to educational opportunity. Experts' advice about giftedness also altered expectations about childrearing and encouraged parents to become more involved in their child's educational development. This argument puts the history of psychology in conversation with histories of parenting, and it evidences how the discourse on giftedness impacted institutional inequality both through merit-based gifted and talented programs and by impacting ideologies of parenting. Thus, I provide a more comprehensive account of how and why giftedness profoundly shaped both the school and the home. This article considers the cultural work the discourse accomplished; it gave the public the impression that disparities in educational achievement between individuals and groups could be explained by the parenting a child received, putting significant pressure on all parents to make educational achievement a top priority for their child. [ABSTRACT FROM AUTHOR]

Exposure to adverse environments during childhood is robustly linked to future aggressive behavior. In this study we tested a model of emotional and neurocognitive mechanisms related to aggressive behavior in the context of childhood adversity. More specifically, we used path analysis to assess the distal contribution of childhood adversity and the more proximal contributions of emotion-related and non-emotion-related forms of impulsivity, and behavioral response inhibition to aggressive behavior. Participants were 180 undergraduates who completed well-validated self-report measures and an emotional version of the Go/No-Go task. The structural equation model was a poor fit for the data (χ2(3) = 23.023, p<. 001; RMR =.131; CFI =.682; RMSEA =.142), though several significant paths emerged. Childhood adversity, emotion-related impulsivity, and behavioral response inhibition displayed direct effects on aggression, collectively accounting for 16.3% of variance. Findings demonstrate the specificity of emotional subtypes of impulsivity in linking childhood adversity and aggression. This study extends work on pathways to aggressive behavior by illustrating the complex relationships of early environmental, cognitive, and emotional mechanisms related to aggression. [ABSTRACT FROM AUTHOR]

Bifocal and multifocal optical devices are intended to get images into focus from objects placed at different distances from the observer. Spectacles, contact lenses, and intraocular lenses can meet the requirements to provide such a solution. Contact lenses provide unique characteristics as a platform for implementing bifocality and multifocality. Compared to spectacles, they are closer to the eye, providing a wider field of view, less distortion, and their use is more consistent as they are not so easily removed along the day. In addition, contact lenses are also minimally invasive, can be easily exchangeable, and, therefore, suitable for conditions in which surgical procedures are not indicated. Contact lenses can remain centered with the eye despite eye movements, providing the possibility for simultaneous imaging from different object distances. The main current indications for bifocal and multifocal contact lenses include presbyopia correction in adult population and myopia control in children. Considering the large numbers of potential candidates for optical correction of presbyopia and the demographic trends in myopia, the potential impact of contact lenses for presbyopia and myopia applications is undoubtedly tremendous. However, the ocular characteristics and expectations vary significantly between young and older candidates and impose different challenges in fitting bifocal and multifocal contact lenses for the correction of presbyopia and myopia control. This review presents the recent developments in material platforms, optical designs, simulated visual performance, and the clinical performance assessment of bifocal and multifocal contact lenses for presbyopia correction and/or myopia progression control. [ABSTRACT FROM AUTHOR]

In contrast to reactive inhibition, intentional inhibition is the internally generated decision to "stop" without any external signals. Whether adults and adolescents' neural correlates on these two inhibitions have any differences is still unknown. We measured 20 adults and 21 adolescents' ERP-related N2 using a free-choice Go/Nogo task. The results of the adult's group showed that the mean amplitude and peak latency of intentional Nogo-N2 did not differ from the reactive Nogo-N2. In contrast, the mean amplitude and peak latency for reactive Nogo-N2 in the adolescent group was significantly greater than what was observed for the intentional Nogo-N2. Comparison across groups revealed that the mean amplitude and peak latency of reactive Nogo-N2 were significantly greater in adolescents than in adults, while intentional Nogo-N2 did not differ between groups. These findings may indicate that adolescents lack of self-control is more reflected in reactive inhibition, if adolescents decide whether to do, they will be as good as adults. [ABSTRACT FROM AUTHOR]

Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t -tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P > 0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective. [ABSTRACT FROM AUTHOR]

"Social facilitation" refers to the enhancement or impairment of performance engendered by the mere presence of others. It has been demonstrated for a diversity of behaviors. This study assessed whether it also concerns attention and eye movements and if yes, which decision-making mechanisms it affects. Human volunteers were tested in three different tasks (saccades, visual search, and continuous performance) either alone or in the presence of a familiar peer. The results failed to reveal any significant peer influence on the visual search and continuous performance tasks. For saccades, by contrast, they showed a negative or positive peer influence depending on the complexity of the testing protocol. Pro-and anti-saccades were both inhibited when pseudorandomly mixed, and both facilitated when performed separately. Peer presence impaired or improved reaction times, i.e., the speed to initiate the saccade, as well as peak velocity, i.e., the driving force moving the eye toward the target. Effect sizes were large, with Cohen's d -values ranging for reaction times (RTs) from 0.50 to 0.95. Analyzing RT distributions using the LATER (Linear Approach to Threshold with Ergodic Rate) model revealed that social inhibition of pro- and anti-saccades in the complex protocol was associated with a significant increase in the rate of rise. The present demonstration that the simple presence of a familiar peer can inhibit or facilitate saccades depending on task difficulty strengthens a growing body of evidence showing social modulations of eye movements and attention processes. The present lack of effect on visual search and continuous performance tasks contrasts with peer presence effects reported earlier using similar tasks, and future studies are needed to determine whether it is due to an intermediate level of difficulty maximizing individual variability. Together with an earlier study of the social inhibition of anti-saccades also using the LATER model, which showed an increase of the threshold, the present increase of the rate of rise suggests that peer presence can influence both the top-down and bottom-up attention-related processes guiding the decision to move the eyes. [ABSTRACT FROM AUTHOR]

This paper presents and discusses the current possibilities of pharmacological intervention in myopia. A review of the latest literature regarding the pharmacological treatment of myopia has been presented. The results of experimental research on the potential use of: atropine, oxyphenonium, pirenzepine, chlorpyrifos, apomorphine, reserpine, 6-hydroxy dopamine, dextromethorphan, MK-801, APV, bicuculline, SR95531, CACA, TPMPA, dextrophanol, levorphanol, D- and L-naloxane, L-NAME, formoguanamine, b-xyloside, the central and peripheral antagonist of VIP, basic fibroblast growth factor, a solution of the basic amino acid salts in the form of succinates, in the treatment of myopia have been described. The clinical use of pirenzepine, 7-methylxanthine, and atropine has been discussed. The obtained results of experimental and clinical studies give hope that a new effective pharmacological method of myopia treatment can be discovered soon. [ABSTRACT FROM AUTHOR]

Research has demonstrated that adolescence is an important time for self- and other-oriented development that underlies many skills vital for becoming a contributing member of society with healthy intergroup relations. It is often assumed that these two processes, thinking about self and thinking about others, are pitted against each other when adolescents engage in social decision making such as giving or sharing. Recent evidence from social neuroscience, however, does not support this notion of conflicting motives, suggesting instead that thinking about self and others relies on a common network of social-affective brain regions, with the medial prefrontal cortex playing a central role in the integration of perspectives related to self and others. Here, we argue that self- and other-oriented thinking are intertwined processes that rely on an overlapping neural network. Adolescents' motivation to contribute to society can be fostered most when self- and other-oriented motives align. [ABSTRACT FROM AUTHOR]

Background: Trainee research collaboratives (TRCs) have pioneered high quality, prospective 'snap-shot' surgical cohort studies in the UK. Outcomes After Kidney injury in Surgery (OAKS) was the first TRC cohort study to attempt to collect one-year follow-up data. The aims of this study were to evaluate one-year follow-up and data completion rates, and to identify factors associated with improved follow-up rates.Methods: In this multicentre study, patients undergoing major gastrointestinal surgery were prospectively identified and followed up at one-year following surgery for six clinical outcomes. The primary outcome for this report was the follow-up rate for mortality at 1 year. The secondary outcome was the data completeness rate in those patients who were followed-up. An electronic survey was disseminated to investigators to identify strategies associated with improved follow-up.Results: Of the 173 centres that collected baseline data, 126 centres registered to participate in one-year follow-up. Overall 62.3% (3482/5585) of patients were followed-up at 1 year; in centres registered to collect one-year outcomes, the follow-up rate was 82.6% (3482/4213). There were no differences in sex, comorbidity, operative urgency, or 7-day postoperative AKI rate between patients who were lost to follow-up and those who were successfully followed-up. In centres registered to collect one-year follow-up outcomes, overall data completeness was 83.1%, with 57.9% (73/126) of centres having ≥95% data completeness. Factors associated with increased likelihood of achieving ≥95% data completeness were total number of patients to be followed-up (77.4% in centres with < 15 patients, 59.0% with 15-29 patients, 51.4% with 30-59 patients, and 36.8% with > 60 patients, p = 0.030), and central versus local storage of patient identifiers (72.5% vs 48.0%, respectively, p = 0.006).Conclusions: TRC methodology can be used to follow-up patients identified in prospective cohort studies at one-year. Follow-up rates are maximized by central storage of patient identifiers. [ABSTRACT FROM AUTHOR]

Purpose. To evaluate the efficacy of epiretinal membrane (ERM) surgery for patients with ERM and glaucoma. Methods. We reviewed the medical records of 20 consecutive ERM patients with glaucoma, who underwent 27-gauge microincision vitrectomy surgery (27GMIVS) with internal limiting membrane (ILM) peeling. The preoperative and 6-month postoperative visual field was tested with the Humphrey Field Analyzer (HFA) 24-2 program. Changes in threshold sensitivity in the HFA test points were analyzed point-by-point, with points classified into groups based on sensitivity as abnormal (less than 5th percentile in pattern deviation) or normal (all other points) and based on location as central (12 central points) or peripheral (all other points) with a linear mixed-effects model. Results. Visual acuity and mean deviation improved postoperatively (P < 0.001 for both) in all patients. Threshold sensitivity in central or peripheral points that were abnormal preoperatively improved postoperatively (P = 0.006 or P < 0.001 , respectively). Threshold sensitivity also improved in the central normal test points (P = 0.03), but not in the peripheral normal points (P = 0.12). Conclusion. Visual acuity improved, and there was no visual field progression, after ERM surgery in glaucomatous eyes during a 6-month postoperative follow-up, suggesting that ERM and ILM removal using 27GMIVS may be effective even in glaucomatous eyes. [ABSTRACT FROM AUTHOR]

Psychological research has demonstrated that humans can think unconsciously. Unconscious thought (UT) refers to cognitive or affective decision-related processes that occur beyond conscious awareness. UT processes are considered more effective in complex decision-making than conscious thought (CT). In addition, holistic representation plays a key role in UT and consists of a multimodal, value-related cognitive process. While the neural correlates of UT have recently been investigated, the holistic representation hypothesis of UT has not been confirmed. Therefore, in the present study, we aimed to further evaluate this hypothesis by utilizing two UT tasks (person and consumer-product evaluations) in conjunction with an improved functional magnetic resonance imaging (fMRI) experimental protocol. Participants evaluated four alternatives with 12 attributes each. In the UT condition, once the decision information had been presented, the participants completed a 1-back task for 120 s and evaluated each alternative, as well as an independent 1-back task in the absence of any decision information. We then performed regression analysis of the UT performance in both tasks. Our results revealed a positive correlation between performance in the UT task and the use of the anterior part of the precuneus/paracentral lobule in the person evaluation task and between performance and the posterior part of the precuneus, postcentral gyrus, middle occipital gyrus, and superior parietal lobule in the consumer-product evaluation task. The involvement of the precuneus area in both tasks was indicative of a multimodal, value-related process and is consistent with the features of holistic representation, supporting a central role for holistic representation in UT. Furthermore, the involvement of different precuneus subregions in the two UT tasks may reflect the task dependency of the key representation critical for advantageous UT. [ABSTRACT FROM AUTHOR]

Herpesviruses must amplify their DNA to load viral particles and they do so in replication compartments. The development and functions of replication compartments during DNA amplification are poorly understood, though. Here we examine 2 functionally distinct replicons in the same cells to dissect DNA amplification within replication compartments. Using a combination of singlecell assays, computational modeling, and population approaches, we show that compartments initially were seeded by single genomes of Epstein–Barr virus (EBV). Their amplification subsequently took 13 to 14 h in individual cells during which their compartments occupied up to 30% of the nucleus and the nuclear volume grew by 50%. The compartmental volumes increased in proportion to the amount of DNA and viral replication proteins they contained. Each compartment synthesized similar levels of DNA, indicating that the total number of compartments determined the total levels of DNA amplification. Further, the amplification, which depended on the number of origins, was regulated differently early and late during the lytic phase; early during the lytic phase, the templates limited DNA synthesis, while later the templates were in excess, coinciding with a decline in levels of the viral replication protein, BMRF1, in the replication compartments. These findings show that replication compartments are factories in which EBV DNA amplification is both clonal and coordinated. [ABSTRACT FROM AUTHOR]