Search

Your search keyword '"Schwartz, Gregory G"' showing total 948 results
Start Over Author "Schwartz, Gregory G"
948 results on '"Schwartz, Gregory G"'

153. Alirocumab after acute coronary syndrome in patients with a history of heart failure.

Author

White, Harvey D, Schwartz, Gregory G, Szarek, Michael, Bhatt, Deepak L, Bittner, Vera A, Chiang, Chern-En, Diaz, Rafael, Goodman, Shaun G, Jukema, Johan Wouter, Loy, Megan, Pagidipati, Neha, Pordy, Robert, Ristić, Arsen D, Zeiher, Andreas M, Wojdyla, Daniel M, Steg, Philippe Gabriel, and Investigators, for the ODYSSEY OUTCOMES

Subjects
ACUTE coronary syndrome, HEART failure patients, MAJOR adverse cardiovascular events, LDL cholesterol
Abstract

Aims Patients with heart failure (HF) have not been shown to benefit from statins. In a post hoc analysis, we evaluated outcomes in ODYSSEY OUTCOMES in patients with vs. without a history of HF randomized to the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab or placebo. Methods and results Among 18 924 patients with recent acute coronary syndrome (ACS) receiving intensive or maximum-tolerated statin treatment, the primary outcome of major adverse cardiovascular events (MACE) was compared in patients with or without a history of HF. The pre-specified secondary outcome of hospitalization for HF was also analysed. Overall, 2815 (14.9%) patients had a history of HF. Alirocumab reduced low-density lipoprotein cholesterol and lipoprotein(a) similarly in patients with or without HF. Overall, alirocumab reduced MACE compared with placebo [hazard ratio (HR): 0.85; 95% confidence interval (CI): 0.78–0.93; P = 0.0001]. This effect was observed among patients without a history of HF (HR: 0.78; 95% CI: 0.70–0.86; P < 0.0001), but not in those with a history of HF (HR: 1.17; 95% CI: 0.97–1.40; P = 0.10) (P interaction = 0.0001). Alirocumab did not reduce hospitalization for HF, overall or in patients with or without prior HF. Conclusion Alirocumab reduced MACE in patients without a history of HF but not in patients with a history of HF. Alirocumab did not reduce hospitalizations for HF in either group. Patients with a history of HF are a high-risk group that does not appear to benefit from PCSK9 inhibition after ACS. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

155. Contributing Authors

Author

Assmann, Gerd, primary, Bagshaw, Deborah, additional, Balasubramanyam, Ashok, additional, Ballantyne, Christie M., additional, Barter, Philip, additional, Bays, Harold, additional, Blumenthal, Roger S., additional, Brewer, H. Bryan, additional, Brown, B. Greg, additional, Brunzell, John D., additional, Campbell, Catherine Y., additional, Canner, Paul L., additional, Carlson, Lars A., additional, Catapano, A.L., additional, Chahil, Tina J., additional, Church, Timothy S., additional, Cohen, David E., additional, Davidson, Michael H., additional, Deedwania, Prakash C., additional, Després, Jean-Pierre, additional, Devaraj, Sridevi, additional, Devine, Patrick J., additional, Fayad, Zahi A., additional, Fazio, Sergio, additional, Fellstrøm, Bengt, additional, Ganz, Peter, additional, Ginsberg, Henry N., additional, Goldberg, Anne Carol, additional, Gotto, Antonio M., additional, Guyton, John R., additional, Harris, William S., additional, Holdaas, Hallvard, additional, Hoogeveen, Ron C., additional, Jacobson, Terry A., additional, Jardine, Alan G., additional, Jenkins, David J.A., additional, Jialal, Ishwarlal, additional, Jones, Peter H., additional, Josse, Andrea R., additional, Kendall, Cyril W.C., additional, Kobashigawa, Jon A., additional, Koschinsky, Marlys L., additional, Kris-Etherton, Penny M., additional, Kurra, Salila, additional, Lavie, Carl J., additional, Le, Ngoc-Anh, additional, Libby, Peter, additional, Linton, MacRae F., additional, Marcovina, Santica M., additional, Mark, Patrick B., additional, McGovern, Mark E., additional, McKenney, James M., additional, Merz, C. Noel Bairey, additional, Miller, Michael, additional, Miller, Yury I., additional, Mora, Samia, additional, Moriarty, Patrick M., additional, Musunuru, Kiran, additional, Myers, Kelly S., additional, Nambi, Vijay, additional, Nguyen, Tri H., additional, Nicholls, Stephen J., additional, Nissen, Steven E., additional, Norata, G.D., additional, Ohlson, Melissa, additional, Packard, Chris J., additional, Pi-Sunyer, F. Xavier, additional, Polk, Donna, additional, Pownall, Henry J., additional, Rader, Daniel J., additional, Rosenson, Robert S., additional, Rudd, James H.F., additional, Saseen, Joseph S., additional, Schwartz, Gregory G., additional, Seedorf, Udo, additional, Sekhar, Rajagopal V., additional, Stone., Neil J., additional, Taylor, Allen J., additional, Tsimikas, Sotirios, additional, Vijayaraghavan, Krishnaswami, additional, Wang, David Q.-H., additional, Wenger, Nanette K., additional, Wiggins, Barbara S., additional, Wilson, Peter W.F., additional, and Wong, Julia M.W., additional

Published
2009
Full Text
View/download PDF

156. Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

Author

Schwartz, Gregory G., Olsson, Anders G., Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J.V., Mundl, Hardi, Nicholls, Stephen J., Shah, Prediman K., Tardif, Jean-Claude, and Wright, R. Scott

Published
2012
Full Text
View/download PDF

158. Potential unrealized mortality benefit of glucagon‐like peptide‐1 receptor agonists and sodium‐glucose co‐transport‐2 inhibitors: A report from the Veterans Health Administration Clinical Assessment, Reporting and Tracking program

Author

Salahuddin, Taufiq, primary, Richardson, Vanessa, additional, McNeal, Demetria M., additional, Henderson, Kamal, additional, Hess, Paul L., additional, Raghavan, Sridharan, additional, Saxon, David R., additional, Valle, Javier A., additional, Waldo, Stephen W., additional, Ho, P. Michael, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

159. Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes

Author

Bhatt, Deepak L., primary, Briggs, Andrew H., additional, Reed, Shelby D., additional, Annemans, Lieven, additional, Szarek, Michael, additional, Bittner, Vera A., additional, Diaz, Rafael, additional, Goodman, Shaun G., additional, Harrington, Robert A., additional, Higuchi, Keiko, additional, Joulain, Florence, additional, Jukema, J. Wouter, additional, Li, Qian H., additional, Mahaffey, Kenneth W., additional, Sanchez, Robert J., additional, Roe, Matthew T., additional, Lopes, Renato D., additional, White, Harvey D., additional, Zeiher, Andreas M., additional, Schwartz, Gregory G., additional, Gabriel Steg, Ph., additional, Bhatt, Deepak L., additional, Tricoci, Pierluigi, additional, Edelberg, Jay M., additional, Hanotin, Corinne, additional, Lecorps, Guillaume, additional, Moryusef, Angèle, additional, Pordy, Robert, additional, Sasiela, William J., additional, and Tamby, Jean-François, additional

Published
2020
Full Text
View/download PDF

160. Abstract 332: Racial Differences in Prescribing of Sodium Glucose Cotransporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists Among Veterans With Type 2 Diabetes and Coronary Artery Disease: Findings From the Veteran’s Administration Clinical Assessment, Reporting, and Tracking Program

Author

McNeal, Demetria M, primary, Peterson, Pamela, additional, Ho, Michael M, additional, Saxon, David, additional, Henderson, Kamal H, additional, Hess, Paul, additional, Valle, Javier A, additional, RAGHAVAN, SRIDHARAN, additional, Schwartz, Gregory G, additional, Salahuddin, Taufiq, additional, and Richardson, Vanessa, additional

Published
2020
Full Text
View/download PDF

161. Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease

Author

Schwartz, Gregory G., primary, Leiter, Lawrence A., additional, Ballantyne, Christie M., additional, Barter, Philip J., additional, Black, Donald M., additional, Kallend, David, additional, Laghrissi-Thode, Fouzia, additional, Leitersdorf, Eran, additional, McMurray, John J.V., additional, Nicholls, Stephen J., additional, Olsson, Anders G., additional, Preiss, David, additional, Shah, Prediman K., additional, Tardif, Jean-Claude, additional, and Kittelson, John, additional

Published
2020
Full Text
View/download PDF

162. APOLIPOPROTEIN B, PCSK9 INHIBITION WITH ALIROCUMAB, AND ISCHEMIC CARDIOVASCULAR EVENTS AFTER ACUTE CORONARY SYNDROME: INSIGHTS FROM THE ODYSSEY OUTCOMES TRIAL

Author

Hagstrom, Emil, primary, Steg, Philippe Gabriel, additional, Szarek, Michael, additional, Bhatt, Deepak, additional, Bittner, Vera, additional, Danchin, Nicolas, additional, Diaz, Rafael, additional, Goodman, Shaun, additional, Harrington, Robert A., additional, Jukema, Johan Wouter, additional, Kim, Yong-Un, additional, Liberopoulos, Evangelos, additional, Marx, Nikolaus, additional, McGinniss, Jennifer, additional, Roe, Matthew, additional, Louie, Michael, additional, White, Harvey, additional, Zeiher, Andreas, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

163. ACHIEVEMENT OF NEW EUROPEAN DYSLIPIDEMIA-GUIDELINE LOW-DENSITY LIPOPROTEIN CHOLESTEROL TREATMENT GOALS AFTER ACUTE CORONARY SYNDROME: INSIGHTS FROM ODYSSEY OUTCOMES

Author

Landmesser, Ulf, primary, McGinniss, Jennifer, additional, Steg, Philippe Gabriel, additional, Bhatt, Deepak, additional, Bittner, Vera, additional, Diaz, Rafael, additional, Goodman, Shaun, additional, Harrington, Robert A., additional, Jukema, Johan Wouter, additional, Laucevicius, Aleksandras, additional, Pecin, Ivan, additional, Pordy, Robert, additional, Poulsen, Steen, additional, Roe, Matthew, additional, Sourdille, Timothee, additional, Szarek, Michael, additional, White, Harvey, additional, Zeiher, Andreas, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

164. ALIROCUMAB AND CARDIOVASCULAR OUTCOMES IN WOMEN AFTER AN ACUTE CORONARY SYNDROME: AN ODYSSEY OUTCOMES TRIAL ANALYSIS

Author

Bittner, Vera, primary, McGinniss, Jennifer, additional, Schwartz, Gregory G., additional, Bhatt, Deepak, additional, Chua, Terrance, additional, de Silva, H. Asita, additional, Diaz, Rafael, additional, Dorobantu, Maria, additional, Goodman, Shaun, additional, Harrington, Robert A., additional, Jukema, Johan Wouter, additional, Kim, Yong-Un, additional, Pordy, Robert, additional, Roe, Matthew, additional, Szarek, Michael, additional, White, Harvey, additional, Zeiher, Andreas M., additional, and Steg, Philippe Gabriel, additional

Published
2020
Full Text
View/download PDF

165. Association of high-density lipoprotein particle concentration with cardiovascular risk following acute coronary syndrome: A case-cohort analysis of the dal-Outcomes trial

Author

Salahuddin, Taufiq, primary, Kittelson, John, additional, Tardif, Jean-Claude, additional, Shah, Prediman K., additional, Olsson, Anders G., additional, Nicholls, Stephen J., additional, Leitersdorf, Eran, additional, Leiter, Lawrence A., additional, Kallend, David, additional, Black, Donald M., additional, Barter, Philip J., additional, Ballantyne, Christie M., additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

166. POTENTIAL UNREALIZED CARDIOVASCULAR BENEFIT OF NOVEL DIABETES AGENTS IN THE VETERANS HEALTH ADMINISTRATION SYSTEM: INSIGHT FROM THE CLINICAL ASSESSMENT, REPORTING, AND TRACKING (CART) PROGRAM

Author

Salahuddin, Taufiq, primary, McNeal, Demetria, additional, Richardson, Vanessa, additional, Valle, Javier, additional, Henderson, Kamal, additional, Raghavan, Sridharan, additional, Saxon, David, additional, Hess, Paul, additional, Ho, Michael, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

167. EFFECT OF ALIROCUMAB ON FIRST AND TOTAL REVASCULARIZATIONS IN PATIENTS WITH RECENT ACUTE CORONARY SYNDROME IN THE ODYSSEY OUTCOMES TRIAL

Author

Szarek, Michael, primary, Valgimigli, Marco, additional, Zeiher, Andreas, additional, Steg, Philippe Gabriel, additional, Bhatt, Deepak, additional, Bittner, Vera, additional, Chiang, Chern-En, additional, Diaz, Rafael, additional, Goodman, Shaun, additional, Gotcheva, Nina, additional, Harrington, Robert A., additional, Jukema, Johan Wouter, additional, Kim, Hyo-Soo, additional, Kim, Yong-Un, additional, Morais, Joao, additional, Pordy, Robert, additional, Roe, Matthew, additional, White, Harvey, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

168. ELIGIBILITY FOR AND USE OF SODIUM GLUCOSE COTRANSPORTER-2 INHIBITORS AND GLUCAGON-LIKE PEPTIDE-1 AGONISTS IN VETERANS WITH TYPE 2 DIABETES AND CORONARY ARTERY DISEASE: PROSPECTIVE ANALYSIS FROM THE CARDIAC CATHETERIZATION LAB CLINICAL ASSESSMENT, REPORTING, AND TRACKING (CART) PROGRAM

Author

McNeal, Demetria, primary, Salahuddin, Taufiq, additional, Valle, Javier, additional, Henderson, Kamal, additional, Richardson, Vanessa, additional, Raghavan, Sridharan, additional, Saxon, David, additional, Hess, Paul, additional, Ho, Michael, additional, and Schwartz, Gregory G., additional

Published
2020
Full Text
View/download PDF

170. Reply

Author

Zijlstra, Laurien E., primary, Schwartz, Gregory G., additional, Steg, Philippe Gabriel, additional, and Jukema, J. Wouter, additional

Published
2020
Full Text
View/download PDF

171. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial

Author

Ray, Kausik K, primary, Colhoun, Helen M, additional, Szarek, Michael, additional, Baccara-Dinet, Marie, additional, Bhatt, Deepak L, additional, Bittner, Vera A, additional, Budaj, Andrzej J, additional, Diaz, Rafael, additional, Goodman, Shaun G, additional, Hanotin, Corinne, additional, Harrington, Robert A, additional, Jukema, J Wouter, additional, Loizeau, Virginie, additional, Lopes, Renato D, additional, Moryusef, Angèle, additional, Murin, Jan, additional, Pordy, Robert, additional, Ristic, Arsen D, additional, Roe, Matthew T, additional, Tuñón, José, additional, White, Harvey D, additional, Zeiher, Andreas M, additional, Schwartz, Gregory G, additional, Steg, Philippe Gabriel, additional, Schwartz, Gregory G., additional, Steg, Ph. Gabriel, additional, Bhatt, Deepak L., additional, Bittner, Vera A., additional, Goodman, Shaun G., additional, Harrington, Robert A., additional, Jukema, J. Wouter, additional, White, Harvey D., additional, Zeiher, Andreas M., additional, Tricoci, Pierluigi, additional, Roe, Matthew T., additional, Mahaffey, Kenneth W., additional, Edelberg, Jay M., additional, Lecorps, Guillaume, additional, Sasiela, William J., additional, Tamby, Jean-François, additional, Aylward, Philip E., additional, Drexel, Heinz, additional, Sinnaeve, Peter, additional, Dilic, Mirza, additional, Lopes, Renato D., additional, Gotcheva, Nina N., additional, Prieto, Juan-Carlos, additional, Yong, Huo, additional, López-Jaramillo, Patricio, additional, Pećin, Ivan, additional, Reiner, Zeljko, additional, Ostadal, Petr, additional, Viigimaa, Margus, additional, Nieminen, Markku S., additional, Chumburidze, Vakhtang, additional, Marx, Nikolaus, additional, Danchin, Nicolas, additional, Liberopoulos, Evangelos, additional, Montenegro Valdovinos, Pablo Carlos, additional, Tse, Hung-Fat, additional, Kiss, Robert Gabor, additional, Xavier, Denis, additional, Zahger, Doron, additional, Valgimigli, Marco, additional, Kimura, Takeshi, additional, Kim, Hyo Soo, additional, Kim, Sang-Hyun, additional, Erglis, Andrejs, additional, Laucevicius, Aleksandras, additional, Kedev, Sasko, additional, Yusoff, Khalid, additional, Ramos López, Gabriel Arturo, additional, Alings, Marco, additional, Halvorsen, Sigrun, additional, Correa Flores, Roger M., additional, Budaj, Andrzej, additional, Morais, Joao, additional, Dorobantu, Maria, additional, Karpov, Yuri, additional, Ristic, Arsen D., additional, Chua, Terrance, additional, Fras, Zlatko, additional, Dalby, Anthony J., additional, de Silva, H. Asita, additional, Hagström, Emil, additional, Landmesser, Ulf, additional, Chiang, Chern-En, additional, Sritara, Piyamitr, additional, Guneri, Sema, additional, Parkhomenko, Alexander, additional, Ray, Kausik K., additional, Moriarty, Patrick M., additional, Vogel, Robert, additional, Chaitman, Bernard, additional, Kelsey, Sheryl F., additional, Olsson, Anders G., additional, Rouleau, Jean-Lucien, additional, Simoons, Maarten L., additional, Alexander, Karen, additional, Meloni, Chiara, additional, Rosenson, Robert, additional, Sijbrands, Eric J.G., additional, Alexander, John H., additional, Armaganijan, Luciana, additional, Bagai, Akshay, additional, Bahit, Maria Cecilia, additional, Brennan, J. Matthew, additional, Clifton, Shaun, additional, DeVore, Adam D., additional, Deloatch, Shalonda, additional, Dickey, Sheila, additional, Dombrowski, Keith, additional, Ducrocq, Grégory, additional, Eapen, Zubin, additional, Endsley, Patricia, additional, Eppinger, Arleen, additional, Harrison, Robert W., additional, Hess, Connie Ng, additional, Hlatky, Mark A., additional, Jordan, Joseph Dedrick, additional, Knowles, Joshua W., additional, Kolls, Bradley J., additional, Kong, David F., additional, Leonardi, Sergio, additional, Lillis, Linda, additional, Maron, David J., additional, Marcus, Jill, additional, Mathews, Robin, additional, Mehta, Rajendra H., additional, Mentz, Robert J., additional, Moreira, Humberto Graner, additional, Patel, Chetan B., additional, Bernardez-Pereira, Sabrina, additional, Perkins, Lynn, additional, Povsic, Thomas J., additional, Puymirat, Etienne, additional, Schuyler Jones, William, additional, Shah, Bimal R., additional, Sherwood, Matthew W., additional, Stringfellow, Kenya, additional, Sujjavanich, Darin, additional, Toma, Mustafa, additional, Trotter, Charlene, additional, Van Diepen, Sean, additional, Wilson, Matthew D., additional, Yan, Andrew T., additional, Schiavi, Lilia B., additional, Garrido, Marcelo, additional, Alvarisqueta, Andrés F., additional, Sassone, Sonia A., additional, Bordonava, Anselmo P., additional, Alves De Lima, Alberto E., additional, Schmidberg, Jorge M., additional, Duronto, Ernesto A., additional, Caruso, Orlando C., additional, Novaretto, Leonardo P., additional, Hominal, Miguel Angel, additional, Montaña, Oscar R., additional, Caccavo, Alberto, additional, Gomez Vilamajo, Oscar A., additional, Lorenzatti, Alberto J., additional, Cartasegna, Luis R., additional, Paterlini, Gustavo A., additional, Mackinnon, Ignacio J., additional, Caime, Guillermo D., additional, Amuchastegui, Marcos, additional, Salomone, Oscar, additional, Codutti, Oscar R., additional, Jure, Horacio O., additional, Bono, Julio OE, additional, Hrabar, Adrian D., additional, Vallejos, Julio A., additional, Ahuad Guerrero, Rodolfo A., additional, Novoa, Federico, additional, Patocchi, Cristian A., additional, Zaidman, Cesar J., additional, Giuliano, Maria E., additional, Dran, Ricardo D., additional, Vico, Marisa L., additional, Carnero, Gabriela S., additional, Guzman, Pablo N., additional, Medrano Allende, Juan C., additional, Garcia Brasca, Daniela F., additional, Bustamante Labarta, Miguel H, additional, Nani, Sebastian, additional, Blumberg, Eduardo DS, additional, Colombo, Hugo R, additional, Liberman, Alberto, additional, Fuentealba, Victorino, additional, Luciardi, Hector L, additional, Waisman, Gabriel D, additional, Berli, Mario A, additional, Garcia Duran, Ruben O, additional, Cestari, Horacio G, additional, Luquez, Hugo A, additional, Giordano, Jorge A, additional, Saavedra, Silvia S, additional, Zapata, Gerardo, additional, Costamagna, Osvaldo, additional, Llois, Susana, additional, Waites, Jonathon H, additional, Collins, Nicholas, additional, Soward, Allan, additional, Hii, Chris LS, additional, Shaw, James, additional, Arstall, Margaret A, additional, Horowitz, John, additional, Ninio, Daniel, additional, Rogers, James F, additional, Colquhoun, David, additional, Oqueli Flores, Romulo E, additional, Roberts-Thomson, Philip, additional, Raffel, Owen, additional, Lehman, Sam J, additional, Aroney, Constantine, additional, Coverdale, Steven GM, additional, Garrahy, Paul J, additional, Starmer, Gregory, additional, Sader, Mark, additional, Carroll, Patrick A, additional, Dick, Ronald, additional, Zweiker, Robert, additional, Hoppe, Uta, additional, Huber, Kurt, additional, Berger, Rudolf, additional, Delle-Karth, Georg, additional, Frey, Bernhard, additional, Weidinger, Franz, additional, Faes, Dirk, additional, Hermans, Kurt, additional, Pirenne, Bruno, additional, Leone, Attilio, additional, Hoffer, Etienne, additional, Vrolix, Mathias CM, additional, De Wolf, Luc, additional, Wollaert, Bart, additional, Castadot, Marc, additional, Dujardin, Karl, additional, Beauloye, Christophe, additional, Vervoort, Geert, additional, Striekwold, Harry, additional, Convens, Carl, additional, Roosen, John, additional, Barbato, Emanuele, additional, Claeys, Marc, additional, Cools, Frank, additional, Terzic, Ibrahim, additional, Barakovic, Fahir, additional, Midzic, Zlatko, additional, Pojskic, Belma, additional, Fazlibegovic, Emir, additional, Kulić, Mehmed, additional, Durak-Nalbantic, Azra, additional, Vulic, Dusko, additional, Muslibegovic, Adis, additional, Goronja, Boris, additional, Reis, Gilmar, additional, Sousa, Luciano, additional, Nicolau, Jose C, additional, Giorgeto, Flavio E, additional, Silva, Ricardo P, additional, Nigro Maia, Lilia, additional, Rech, Rafael, additional, Rossi, Paulo RF, additional, Cerqueira, Maria José AG, additional, Duda, Norberto, additional, Kalil, Renato, additional, Kormann, Adrian, additional, Abrantes, José Antonio M, additional, Pimentel Filho, Pedro, additional, Soggia, Ana Priscila, additional, de Santos, Mayler ON, additional, Neuenschwander, Fernando, additional, Bodanese, Luiz C, additional, Michalaros, Yorghos L, additional, Eliaschewitz, Freddy G, additional, Vidotti, Maria H, additional, Leaes, Paulo E, additional, Botelho, Roberto V, additional, Kaiser, Sergio, additional, Manenti, Euler Roberto Fernandes, additional, Precoma, Dalton B, additional, Moura Jorge, Jose C, additional, de B Silva, Pedro G, additional, Silveira, Jose A, additional, Saporito, Wladmir, additional, Marin-Neto, Jose A, additional, Feitosa, Gilson S, additional, Ritt, Luiz Eduardo F, additional, de Souza, Juliana A, additional, Costa, Fernando, additional, Souza, Weimar KSB, additional, Reis, Helder JL, additional, Machado, Leandro, additional, Ayoub, José Carlos Aidar, additional, Todorov, Georgi V, additional, Nikolov, Fedya P, additional, Velcheva, Elena S, additional, Tzekova, Maria L, additional, Benov, Haralambi O, additional, Petranov, Stanislav L, additional, Tumbev, Haralin S, additional, Shehova-Yankova, Nina S, additional, Markov, Dimitar T, additional, Raev, Dimitar H, additional, Mollov, Mihail N, additional, Kichukov, Kostadin N, additional, Ilieva-Pandeva, Katya A, additional, Ivanova, Raya, additional, Gospodinov, Maryana, additional, Mincheva, Valentina M, additional, Lazov, Petar V, additional, Dimov, Bojidar I, additional, Senaratne, Manohara, additional, Stone, James, additional, Kornder, Jan, additional, Pearce, Stephen, additional, Dion, Danielle, additional, Savard, Daniel, additional, Pesant, Yves, additional, Pandey, Amritanshu, additional, Robinson, Simon, additional, Gosselin, Gilbert, additional, Vizel, Saul, additional, Hoag, Gordon, additional, Bourgeois, Ronald, additional, Morisset, Anne, additional, Sabbah, Eric, additional, Sussex, Bruce, additional, Kouz, Simon, additional, MacDonald, Paul, additional, Diaz, Ariel, additional, Michaud, Nicolas, additional, Fell, David, additional, Leung, Raymond, additional, Vuurmans, Tycho, additional, Lai, Christopher, additional, Nigro, Frank, additional, Davies, Richard, additional, Nogareda, Gustavo, additional, Vijayaraghavan, Ram, additional, Ducas, John, additional, Lepage, Serge, additional, Mehta, Shamir, additional, Cha, James, additional, Dupuis, Robert, additional, Fong, Peter, additional, Lutchmedial, Sohrab, additional, Rodes-Cabau, Josep, additional, Fadlallah, Hussein, additional, Cleveland, David, additional, Huynh, Thao, additional, Bata, Iqbal, additional, Hameed, Adnan, additional, Pincetti, Cristian, additional, Potthoff, Sergio, additional, Prieto, Juan C, additional, Acevedo, Monica, additional, Aguirre, Arnoldo, additional, Vejar, Margarita, additional, Yañez, Mario, additional, Araneda, Guillermo, additional, Fernandez, Mauricio, additional, Perez, Luis, additional, Varleta, Paola, additional, Florenzano, Fernando, additional, Huidobro, Laura, additional, Raffo, Carlos A, additional, Olivares, Claudia, additional, Nahuelpan, Leonardo, additional, Montecinos, Humberto, additional, Chen, Jiyan, additional, Dong, Yugang, additional, Huang, Weijian, additional, Wang, Jianzhong, additional, Huang, Shi'An, additional, Yao, Zhuhua, additional, Li, Xiang, additional, Cui, Lan, additional, Lin, Wenhua, additional, Sun, Yuemin, additional, Wang, Jingfeng, additional, Li, Jianping, additional, Zhang, Xuelian, additional, Zhu, Hong, additional, Chen, Dandan, additional, Huang, Lan, additional, Dong, Shaohong, additional, Su, Guohai, additional, Xu, Biao, additional, Su, Xi, additional, Cheng, Xiaoshu, additional, Lin, Jinxiu, additional, Zong, Wenxia, additional, Li, Huanming, additional, Feng, Yi, additional, Xu, Dingli, additional, Yang, Xinchun, additional, Ke, Yuannan, additional, Lin, Xuefeng, additional, Zhang, Zheng, additional, Zheng, Zeqi, additional, Luo, Zhurong, additional, Chen, Yundai, additional, Ding, Chunhua, additional, Zhong, Yi, additional, Zheng, Yang, additional, Li, Xiaodong, additional, Peng, Daoquan, additional, Zhao, Shuiping, additional, Li, Ying, additional, Liu, Xuebo, additional, Wei, Meng, additional, Liu, Shaowen, additional, Yu, Yihua, additional, Qu, Baiming, additional, Jiang, Weihong, additional, Zhou, Yujie, additional, Zhao, Xingsheng, additional, Yuan, Zuyi, additional, Guo, Ying, additional, Xu, Xiping, additional, Shi, Xubo, additional, Ge, Junbo, additional, Fu, Guosheng, additional, Bai, Feng, additional, Fang, Weiyi, additional, Shou, Xiling, additional, Yang, Xiangjun, additional, Wang, Jian'An, additional, Xiang, Meixiang, additional, Sun, Yingxian, additional, Lu, Qinghua, additional, Zhang, Ruiyan, additional, Zhu, Jianhua, additional, Xu, Yizhou, additional, Fan, Zhongcai, additional, Li, Tianchang, additional, Wu, Chun, additional, Jaramillo, Nicolas, additional, Sanchez Vallejo, Gregorio, additional, Luna Botia, Diana C, additional, Botero Lopez, Rodrigo, additional, Molina De Salazar, Dora I, additional, Cadena Bonfanti, Alberto J, additional, Cotes Aroca, Carlos, additional, Diego Higuera, Juan, additional, Blanquicett, Marco, additional, Barrera Silva, Sandra I, additional, Garcia Lozada, Henry J, additional, Coronel Arroyo, Julian A, additional, Accini Mendoza, Jose L, additional, Fernandez Ruiz, Ricardo L, additional, Quintero Ossa, Alvaro M., additional, Manzur Jatin, Fernando G, additional, Sotomayor Herazo, Aristides, additional, Castellanos Parada, Jeffrey, additional, Suarez Arambula, Rafael, additional, Urina Triana, Miguel A, additional, Fernandez Trujillo, Angela M, additional, Strozzi, Maja, additional, Car, Siniša, additional, Jerić, Melita, additional, Miličić, Davor, additional, Benčić, Martina Lovrić, additional, Pintarić, Hrvoje, additional, Prvulović, Đeiti, additional, Šikić, Jozica, additional, Peršić, Viktor, additional, Mileta, Dean, additional, Štambuk, Kresimir, additional, Babić, Zdravko, additional, Tomulic, Vjekoslav, additional, Lukenda, Josip, additional, Mejic-Krstulovic, Stanka, additional, Starcevic, Boris, additional, Spinar, Jindrich, additional, Horak, David, additional, Velicka, Zdenek, additional, Stasek, Josef, additional, Alan, David, additional, Machova, Vilma, additional, Linhart, Ales, additional, Novotny, Vojtech, additional, Kaucak, Vladimir, additional, Rokyta, Richard, additional, Naplava, Robert, additional, Coufal, Zdenek, additional, Adamkova, Vera, additional, Podpera, Ivo, additional, Zizka, Jiri, additional, Motovska, Zuzana, additional, Marusincova, Ivana, additional, Svab, Premysl, additional, Heinc, Petr, additional, Kuchar, Jiri, additional, Povolny, Petr, additional, Matuska, Jiri, additional, Poulsen, Steen H, additional, Raungaard, Bent, additional, Clemmensen, Peter, additional, Bang, Lia E, additional, May, Ole, additional, Bøttcher, Morten, additional, Hove, Jens D, additional, Frost, Lars, additional, Gislason, Gunnar, additional, Larsen, John, additional, Betton Johansen, Peter, additional, Hald, Flemming, additional, Johansen, Peter, additional, Jeppesen, Jørgen, additional, Nielsen, Tonny, additional, Kristensen, Kjeld S, additional, Walichiewicz, Piotr Maria, additional, Lomholdt, Jens D, additional, Klausen, Ib C, additional, Nielsen, Peter Kaiser, additional, Davidsen, Flemming, additional, Videbaek, Lars, additional, Soots, Mai, additional, Vahula, Veiko, additional, Hedman, Anu, additional, Soopõld, Üllar, additional, Märtsin, Kaja, additional, Jurgenson, Tiina, additional, Kristjan, Arved, additional, Helsinki, Juhani K, additional, Vikman, Saila, additional, Huikuri, Heikki, additional, Airaksinen, Juhani, additional, Coste, Pierre, additional, Ferrari, Emile, additional, Morel, Olivier, additional, Montalescot, Gilles, additional, Machecourt, Jacques, additional, Barone-Rochette, Gilles, additional, Mansourati, Jacques, additional, Cottin, Yves, additional, Leclercq, Florence, additional, Belhassane, Abdelkader, additional, Delarche, Nicolas, additional, Boccara, Franck, additional, Paganelli, Franck, additional, Clerc, Jérôme, additional, Schiele, Francois, additional, Aboyans, Victor, additional, Probst, Vincent, additional, Berland, Jacques, additional, Lefèvre, Thierry, additional, Citron, Bernard, additional, Khintibidze, Irakli, additional, Shaburishvili, Tamaz, additional, Pagava, Zurab, additional, Ghlonti, Ramaz, additional, Lominadze, Zaza, additional, Khabeishvili, George, additional, Hemetsberger, Rayyan, additional, Edward, Kemala, additional, Rauch-Kröhnert, Ursula, additional, Stratmann, Matthias, additional, Appel, Karl-Friedrich, additional, Schmidt, Ekkehard, additional, Omran, Heyder, additional, Stellbrink, Christoph, additional, Dorsel, Thomas, additional, Lianopoulos, Emmanouil, additional, Vöhringer, Hans Friedrich, additional, Marx, Roger, additional, Zirlik, Andreas, additional, Schellenberg, Detlev, additional, Heitzer, Thomas, additional, Laufs, Ulrich, additional, Werner, Christian, additional, Gielen, Stephan, additional, Nuding, Sebastian, additional, Winkelmann, Bernhard, additional, Behrens, Steffen, additional, Sydow, Karsten, additional, Karakas, Mahir, additional, Simonis, Gregor, additional, Muenzel, Thomas, additional, Werner, Nikos, additional, Leggewie, Stefan, additional, Böcker, Dirk, additional, Braun-Dullaeus, Rüdiger, additional, Toursarkissian, Nicole, additional, Jeserich, Michael, additional, Weißbrodt, Matthias, additional, Schaeufele, Tim, additional, Weil, Joachim, additional, Völler, Heinz, additional, Waltenberger, Johannes, additional, Natour, Mohammed, additional, Schmitt, Susanne, additional, Müller-Wieland, Dirk, additional, Steiner, Stephan, additional, Heidenreich, Lothar, additional, Offers, Elmar, additional, Gremmler, Uwe, additional, Killat, Holger, additional, Rieker, Werner, additional, Patsilinakos, Sotiris, additional, Kartalis, Athanasios, additional, Manolis, Athanassios, additional, Sionis, Dimitrios, additional, Chachalis, Geargios, additional, Skoumas, Ioannis, additional, Athyros, Vasilios, additional, Vardas, Panagiotis, additional, Parthenakis, Frangkiskos, additional, Alexopoulos, Dimitrios, additional, Hahalis, Georgios, additional, Lekakis, John, additional, Hatzitolios, Apostolos, additional, Fausto Ovando, Sergio R, additional, Arango Benecke, Juan L, additional, Rodriguez De Leon, Edgar R, additional, Yan, Bryan PY, additional, Siu, David CW, additional, Turi, Tibor, additional, Merkely, Bela, additional, Ungi, Imre, additional, Lupkovics, Geza, additional, Nagy, Lajos, additional, Katona, András, additional, Édes, István, additional, Müller, Gábor, additional, Horvath, Iván, additional, Kapin, Tibor, additional, Szigeti, Zsolt, additional, Faluközy, József, additional, Kumbla, Mukund, additional, Sandhu, Manjinder, additional, Annam, Sharath, additional, Proddutur, Naveen Reddy, additional, Regella, Reddy, additional, Premchand, Rajendra K, additional, Mahajan, Ajaykumar, additional, Pawar, Sudhir, additional, Abhyanakar, Atul D, additional, Kerkar, Prafulla, additional, Govinda, Ravishankar A, additional, Oomman, Abraham, additional, Sinha, Dhurjati, additional, Patil, Sachin N, additional, Kahali, Dhiman, additional, Sawhney, Jitendra, additional, Joshi, Abhijeet B, additional, Chaudhary, Sanjeev, additional, Harkut, Pankaj, additional, Guha, Santanu, additional, Porwal, Sanjay, additional, Jujjuru, Srimannarayana, additional, Pothineni, Ramesh B, additional, Monteiro, Minguel R, additional, Khan, Aziz, additional, Iyengar, Shamanna S, additional, Grewal, Jasprakash Singh, additional, Chopda, Manoj, additional, Fulwani, Mahesh C, additional, Patange, Aparna, additional, Sachin, Patil, additional, Chopra, Vijay K, additional, Goyal, Naresh K, additional, Shinde, Rituparna, additional, Manakshe, Gajendra V, additional, Patki, Nitin, additional, Sethi, Sumeet, additional, Munusamy, Vengatesh, additional, Karna, Sunil, additional, Thanvi, Sunil, additional, Adhyapak, Srilakshmi, additional, Patil, Chandrakant, additional, Pandurangi, Ulhas, additional, Mathur, Rishabh, additional, Gupta, Jugal, additional, Kalashetti, Suhas, additional, Bhagwat, Ajit, additional, Raghuraman, Bagirath, additional, Yerra, Shiv Kumar, additional, Bhansali, Prasant, additional, Borse, Rohidas, additional, Rahul, Patil, additional, Das, Srihari, additional, Kumar, Vinay, additional, Abdullakutty, Jabir, additional, Saathe, Shireesh, additional, Palimkar, Priya, additional, Sathe, Shireesh, additional, Atar, Shaul, additional, Shechter, Michael, additional, Mosseri, Morris, additional, Arbel, Yaron, additional, Ehud, Chorin, additional, Ofer, Havakuk, additional, Lotan, Chaim, additional, Rosenschein, Uri, additional, Katz, Amos, additional, Henkin, Yaakov, additional, Francis, Adi, additional, Klutstein, Marc, additional, Nikolsky, Eugenia, additional, Zukermann, Robert, additional, Turgeman, Yoav, additional, Halabi, Majdi, additional, Marmor, Alon, additional, Kornowski, Ran, additional, Jonas, Michael, additional, Amir, Offer, additional, Hasin, Yonathan, additional, Rozenman, Yoseph, additional, Fuchs, Shmuel, additional, Zvi, Vered, additional, Hussein, Osamah, additional, Gavish, Dov, additional, Vered, Zvi, additional, Caraco, Yoseph, additional, Elias, Mazen, additional, Tov, Naveh, additional, Wolfovitz, Efrat, additional, Lishner, Michael, additional, Elias, Nizar, additional, Piovaccari, Giancarlo, additional, De Pellegrin, Annamaria, additional, Garbelotto, Raffaella, additional, Guardigli, Gabriele, additional, Marco, Valgimigli, additional, Licciardello, Giovanni, additional, Auguadro, Carla, additional, Scalise, Filippo, additional, Cuccia, Claudio, additional, Salvioni, Alessandro, additional, Musumeci, Giuseppe, additional, Senni, Michelle, additional, Calabrò, Paolo, additional, Novo, Salvatore, additional, Faggiano, Pompilio, additional, Metra, Marco, additional, De Cesare, Nicoletta B, additional, Berti, Sergio, additional, Cavallini, Claudio, additional, Puccioni, Enrico, additional, Galvani, Marcello, additional, Tespili, Maurizio, additional, Piatti, Piermarco, additional, Palvarini, Michela, additional, De Luca, Giuseppe, additional, Violini, Roberto, additional, De Leo, Alessandro, additional, Olivari, Zoran, additional, Perrone Filardi, Pasquale, additional, Ferratini, Maurizio, additional, Racca, Vittorio, additional, Dai, Kazuoki, additional, Shimatani, Yuji, additional, Kamiya, Haruo, additional, Ando, Kenji, additional, Takeda, Yoshihiro, additional, Morino, Yoshihiro, additional, Hata, Yoshiki, additional, Kimura, Kazuo, additional, Kishi, Koichi, additional, Michishita, Ichiro, additional, Uehara, Hiroki, additional, Higashikata, Toshinori, additional, Hirayama, Atsushi, additional, Hirooka, Keiji, additional, Doi, Yasuji, additional, Sakagami, Satoru, additional, Taguchi, Shuichi, additional, Koike, Akihiro, additional, Fujinaga, Hiroyuki, additional, Koba, Shinji, additional, Kozuma, Ken, additional, Kawasaki, Tomohiro, additional, Ono, Yujiro, additional, Shimizu, Masatoshi, additional, Katsuda, Yousuke, additional, Wada, Atsuyuki, additional, Shinke, Toshiro, additional, Ako, Junya, additional, Fujii, Kenshi, additional, Takahashi, Toshiyuki, additional, Sakamoto, Tomohiro, additional, Nakao, Koichi, additional, Furukawa, Yutaka, additional, Sugino, Hiroshi, additional, Tamura, Ritsu, additional, Mano, Toshiaki, additional, Uematsu, Masaaki, additional, Utsu, Noriaki, additional, Ito, Kashima, additional, Haraguchi, Takuya, additional, Sato, Katsuhiko, additional, Ueda, Yasunori, additional, Nishibe, Akira, additional, Fujimoto, Kazuteru, additional, Masutani, Motomaru, additional, Yoon, Jung Han, additional, Kim, Hack-Lyoung, additional, Park, Hun Sik, additional, Chae, In-Ho, additional, Kim, Moo Hyun, additional, Jeong, Myung Ho, additional, Rha, Seungwoon, additional, Kim, Chongjin, additional, Kim, Hyo-Soo, additional, Kim, Hae Young, additional, Hong, Taekjong, additional, Tahk, Seung-Jea, additional, Kim, Youngkwon, additional, Busmane, Arija, additional, Pontaga, Natalija, additional, Strelnieks, Aldis, additional, Mintale, Iveta, additional, Sime, Iveta, additional, Petrulioniene, Zaneta, additional, Kavaliauskiene, Roma, additional, Jurgaitiene, Ruta, additional, Sakalyte, Gintare, additional, Slapikas, Rimvydas, additional, Norkiene, Sigute, additional, Misonis, Nerijus, additional, Kibarskis, Aleksandras, additional, Kubilius, Raimondas, additional, Bojovski, Stojko, additional, Lozance, Nensi, additional, Kjovkaroski, Aleksandar, additional, Doncovska, Snezana, additional, Ong, Tiong Kiam, additional, Kasim, Sazzli, additional, Maskon, Oteh, additional, Kandasamy, Balachandran, additional, Liew, Houng B, additional, Wan Mohamed, Wan Mohd Izani, additional, García Castillo, Armando, additional, Carrillo Calvillo, Jorge, additional, Fajardo Campos, Pedro, additional, Núñez Fragoso, Juan Carlos, additional, Bayram Llamas, Edmundo Alfredo, additional, Alcocer Gamba, Marco Antonio, additional, Carranza Madrigal, Jaime, additional, González Salas, Luis Gerardo, additional, López Rosas, Enrique, additional, González Díaz, Belinda, additional, Salcido Vázquez, Eduardo, additional, Nacoud Ackar, Alfredo, additional, Llamas Esperón, Guillermo Antonio, additional, Martínez Sánchez, Carlos Rodolfo, additional, Guerrero De Leon, María, additional, Suarez Otero, Rodrigo, additional, Fanghänel Salmón, Guillermo, additional, Pérez Ríos, Jesús Antonio, additional, Garza Ruíz, José Angel, additional, Breedveld, Robert W, additional, Feenema-Aardema, Margriet, additional, Borger-Van Der Burg, Alida, additional, Hoogslag, Pieter AM, additional, Suryapranata, Harry, additional, Oomen, Antonius, additional, Van Haelst, Paulus, additional, Wiersma, Jacobijne J, additional, Basart, Dirk, additional, Van Der Wal, Ruud MA, additional, Zwart, Peter, additional, Monraats, Pascalle, additional, Van Kesteren, Henricus, additional, Karalis, Ioannis, additional, Jukema, Johan, additional, Verdel, Gerardus JE, additional, Brueren, Bart RG, additional, Troquay, Roland PTh, additional, Viergever, Eric P, additional, Al-Windy, Nadea YY, additional, Bartels, Gerard L, additional, Cornel, Jan H, additional, Hermans, Walter RM, additional, Herrman, Johannes PR, additional, Bos, Robert J, additional, Groutars, Reginald GEJ, additional, Van Der Zwaan, Coenraad C, additional, Kaplan, Refik, additional, Lionarons, Raymond, additional, Ronner, Eelko, additional, Groenemeijer, Bjorn E, additional, Bronzwaer, Patrick NA, additional, Liem, Anho AH, additional, Rensing, Bernard JWM, additional, Bokern, Marcel JJA, additional, Nijmeijer, Remco, additional, Hersbach, Ferry MRJ, additional, Willems, Frank F, additional, Gosselink, Antonius TM, additional, Rasoul, Saman, additional, Elliott, John, additional, Wilkins, Gerard, additional, Fisher, Raewyn, additional, Scott, Douglas, additional, Hart, Hamish, additional, Stewart, Ralph, additional, Harding, Scott, additional, Ternouth, Ian, additional, Fisher, Nicholas, additional, Wilson, Samuel, additional, Aitken, Denise, additional, Anscombe, Russell, additional, Davidson, Laura, additional, Tomala, Tadeusz, additional, Nygård, Ottar, additional, Sparby, Jon Arne, additional, Andersen, Kjell, additional, Gullestad, Lars, additional, Jortveit, Jarle, additional, Munk, Peter S, additional, Singsaas, Erlend gyllensten, additional, Hurtig, Ulf, additional, Calderon Ticona, Jorge R, additional, Durand Velasquez, Julio R, additional, Negron Miguel, Sandra A, additional, Sanabria Perez, Enrique S, additional, Carrion Chambilla, Jesus M, additional, Chavez Ayala, Carlos A, additional, Castillo Leon, Reynaldo P, additional, Vargas Gonzales, Rolando J, additional, Hernandez Zuniga, Jose D, additional, Camacho Cosavalente, Luis A, additional, Bravo Mannucci, Jorge E, additional, Heredia Landeo, Javier, additional, Llerena Navarro, Nassip C, additional, Roldan Concha, Yudy M, additional, Rodriguez Chavez, Víctor E, additional, Anchante Hernandez, Henry A, additional, Zea Nunez, Carlos A, additional, Mogrovejo Ramos, Walter, additional, Ferrolino, Arthur, additional, Sy, Rosa Allyn G, additional, Tirador, Louie, additional, Sy, Rody G, additional, Matiga, Generoso, additional, Coching, Raul Martin, additional, Bernan, Alisa, additional, Rogelio, Gregorio, additional, Morales, Dante D., additional, Tan, Edgar, additional, Sulit, Dennis Jose, additional, Wlodarczak, Adrian, additional, Jaworska, Krystyna, additional, Skonieczny, Grzegorz, additional, Pawlowicz, Lidia, additional, Wojewoda, Pawel, additional, Busz-Papiez, Benita, additional, Bednarski, Janusz, additional, Goch, Aleksander, additional, Staneta, Pawel, additional, Dulak, Elzbieta, additional, Saminski, Krzysztof, additional, Krasowski, Wlodzimierz, additional, Sudnik, Wanda, additional, Zurakowski, Aleksander, additional, Skorski, Marcin, additional, Miklaszewicz, Beata, additional, Kubica, Jacek, additional, Andrzej Lipko, Jan, additional, Kostarska-Srokosz, Edyta, additional, Piepiorka, Marek, additional, Drzewiecka, Anna, additional, Stasiewski, Arkadiusz, additional, Blicharski, Tomasz, additional, Bystryk, Leszek, additional, Szpajer, Michal, additional, Korol, Marek, additional, Czerski, Tomasz, additional, Mirek-Bryniarska, Ewa, additional, Gniot, Jacek, additional, Lubinski, Andrzej, additional, Gorny, Jerzy, additional, Franek, Edward, additional, Raczak, Grzegorz, additional, Szwed, Hanna, additional, Monteiro, Pedro, additional, Mesquita Bastos, Jose, additional, Pereira, Helder H, additional, Martins, Dinis, additional, Seixo, Filipe, additional, Mendonça, Carlos, additional, Botelho, Ana, additional, Caetano, Francisca, additional, Minescu, Bogdan, additional, Istratoaie, Octavian, additional, Tesloianu, Dan N, additional, Cristian, Gabriel, additional, Dumitrescu, Silviu, additional, Podoleanu, Cristian GC, additional, Constantinescu, Mircea CA, additional, Bengus, Cristina M, additional, Militaru, Constantin, additional, Rosu, Doina, additional, Parepa, Irinel R, additional, Matei, Adrian V, additional, Alexandru, Tom M, additional, Malis, Mihaela, additional, Coman, Ioan, additional, Stanescu-Cioranu, Rodica, additional, Dimulescu, Doina, additional, Shvarts, Yury, additional, Orlikova, Olga, additional, Kobalava, Zhanna, additional, Barbarash, Olga L, additional, Markov, Valentin, additional, Lyamina, Nadezhda, additional, Gordienko, Alexander, additional, Zrazhevsky, Konstantin, additional, Vishnevsky, Alexander Y, additional, Gurevich, Victor, additional, Stryuk, Raisa, additional, Lomakin, Nikita V, additional, Bokarev, Igor, additional, Khlevchuk, Tatiana, additional, Shalaev, Sergey, additional, Khaisheva, Larisa, additional, Chizhov, Petr, additional, Viktorova, Inna, additional, Osokina, Natalya, additional, Shchekotov, Vladimir, additional, Akatova, Evgenia, additional, Chumakova, Galina, additional, Libov, Igor, additional, Voevoda, Mikhail I, additional, Tretyakova, Tatyana V, additional, Baranov, Evgeny, additional, Shustov, Sergey, additional, Yakushin, Sergey, additional, Gordeev, Ivan, additional, Khasanov, Niiaz, additional, Reshetko, Olga, additional, Sotnikova, Tatiana, additional, Molchanova, Olga, additional, Nikolaev, Konstantin, additional, Gapon, Liudmila, additional, Baranova, Elena, additional, Shogenov, Zaur, additional, Kosmachova, Elena, additional, Karpov, Yuriy, additional, Povzun, Anton, additional, Egorova, Liudmila, additional, Tyrenko, Vadim V, additional, Ivanov, Igor G, additional, Ilya, Masterov, additional, Kanorsky, Sergey, additional, Simic, Dragan, additional, Ivanovic, Nikola, additional, Davidovic, Goran, additional, Tasic, Nebojsa, additional, Asanin, Milika R., additional, Stojic, Stevo, additional, Apostolovic, Svetlana R., additional, Ilic, Stevan, additional, Putnikovic Tosic, Biljana, additional, Stankovic, Aleksandar, additional, Arandjelovic, Aleksandra, additional, Radovanovic, Slavica, additional, Todic, Branislava, additional, Balinovac, Jovan, additional, Dincic, Dragan V., additional, Seferovic, Petar, additional, Karadzic, Ana, additional, Dodic, Slobodan, additional, Dimkovic, Sinisa, additional, Jakimov, Tamara, additional, Poh, Kian-Keong, additional, Ong, Hean Yee, additional, Tang I-Shing, Justin, additional, Micko, Karol, additional, Nociar, Jan, additional, Pella, Daniel, additional, Fulop, Peter, additional, Hranai, Marian, additional, Palka, Juraj, additional, Mazur, Juraj, additional, Majercák, Ivan, additional, Dzupina, Andrej, additional, Fazekas, František, additional, Gonsorcik, Jozef, additional, Bugan, Viliam, additional, Selecky, Juraj, additional, Kamensky, Gabriel, additional, Strbova, Jaroslava, additional, Smik, Rudolf, additional, Dukat, Andrej, additional, Žuran, Ivan, additional, Poklukar, Janez, additional, Černič Šuligoj, Nataša, additional, Cevc, Matija, additional, Cyster, Henry P, additional, Ranjith, Naresh, additional, Corbett, Clive, additional, Bayat, Junaid, additional, Makotoko, Ellen Makoali, additional, du Toit Theron, Hendrik, additional, Kapp, Ilse E, additional, de V Basson, Matthys M, additional, Lottering, Hanlie, additional, Van Aswegen, Dina, additional, Van Zyl, Louis J, additional, Sebastian, Peter J, additional, Pillay, Thayabran, additional, Saaiman, Jan A, additional, Commerford, Patrick J, additional, Cassimjee, Soraya, additional, Riaz, Garda, additional, Ebrahim, Iftikhar O, additional, Sarvan, Mahomed, additional, Mynhardt, Joseph H, additional, Reuter, Helmuth, additional, Moodley, Rajendran, additional, Vida, Manuel, additional, Cequier Fillat, Angel R., additional, Bodí Peris, Vicente, additional, Fuentes Jimenez, Francisco, additional, Marín, Francisco, additional, Cruz Fernández, Jose M, additional, Hidalgo Urbano, Rafael Jesus, additional, Gil-Extremera, Blas, additional, Toledo, Pablo, additional, Worner Diz, Fernando, additional, Garcia-Dorado, David, additional, Iñiguez, Andres, additional, Tuñón Fernández, José, additional, Gonzalez-Juanatey, Jose R, additional, Fernandez Portales, Javier, additional, Civeira Murillo, Fernando, additional, Matas Pericas, Laia, additional, Zamorano, Jose Luis, additional, De Mora Martin, Manuel, additional, Bruguera Cortada, Jordi, additional, Alonso Martin, Joaquin J, additional, Serrano Antolin, Jose Maria, additional, De Berrazueta Fernández, José R, additional, Vázquez de Prada, José Antonio, additional, Díaz Fernández, Jose Francisco, additional, García Lledó, José Alberto, additional, Cosín Sales, Juan, additional, Botas Rodriguez, Javier, additional, Gusi Tragant, Gabriel, additional, Benedicto, Amparo, additional, Gonzalez-Juanatey, Carlos, additional, Camprubí Potau, Mercedes, additional, Plaza Perez, Ignacio, additional, De La Tassa, César Morís, additional, Loma-Osorio Rincon, Pablo, additional, Balaguer Recena, Javier, additional, Escudier, Juan M, additional, Payeras, Antonio Coca, additional, Alonso Orcajo, Norberto, additional, Valdivielso, Pedro, additional, Constantine, Godwin, additional, Haniffa, Ruvaiz, additional, Tissera, Nirmali, additional, Amarasekera, Stanley, additional, Ponnamperuma, Chandrike, additional, Fernando, Nimali, additional, Fernando, Kaputella, additional, Jayawardena, Jayanthimala, additional, Wijeyasingam, Santharaj, additional, Ranasinghe, Gotabhaya, additional, Ekanayaka, Ruvan, additional, Mendis, Sepalika, additional, Senaratne, Vajira, additional, Mayurathan, Gnanamoorthy, additional, Sirisena, Thilak, additional, Rajapaksha, Ajantha, additional, Herath, Jagath I, additional, Amarasena, Naomali, additional, Berglund, Stefan, additional, Rasmanis, Gundars, additional, Vedin, Ola, additional, Witt, Nils, additional, Mourtzinis, Georgios, additional, Nicol, Peter, additional, Hansen, Ole, additional, Romeo, Stefano, additional, Agergaard Jensen, Steen, additional, Torstensson, Ingemar, additional, Ahremark, Ulf, additional, Sundelin, Torbjörn, additional, Moccetti, Tiziano, additional, Müller, Christian, additional, Mach, Francois, additional, Binde, Ronald, additional, Tsai, Wei-Chuan, additional, Ueng, Kwo-Chang, additional, Lai, Wen-Ter, additional, Liu, Ming-En, additional, Hwang, Juey-Jen, additional, Yin, Wei-Hsian, additional, Hsieh, I-Chang, additional, Hsieh, Ming-Jer, additional, Lin, Wei Hsiang, additional, Kuo, Jen-Yuan, additional, Huang, Tsuei-Yuan, additional, Fang, Chih-Yuan, additional, Kaewsuwanna, Pinij, additional, Soonfuang, Wasant, additional, Jintapakorn, Woravut, additional, Sukonthasarn, Apichard, additional, Wongpraparut, Nattawut, additional, Sastravaha, Krisada, additional, Sansanayudh, Nakarin, additional, Kehasukcharoen, Wirash, additional, Piyayotai, Dilok, additional, Chotnoparatpat, Paiboon, additional, Camsari, Ahmet, additional, Kultursay, Hakan, additional, Mutlu, Bulent, additional, Ersanli, Murat, additional, Demirtas, Mustafa, additional, Kirma, Cevat, additional, Ural, Ertan, additional, Koldas, Lale, additional, Karpenko, Oleksandr, additional, Prokhorov, Alexander, additional, Vakaluyk, Ihor, additional, Myshanych, Halyna, additional, Reshotko, Dmytro, additional, Batushkin, Valeriy, additional, Rudenko, Leonid, additional, Kovalskyi, Ihor, additional, Kushnir, Mykola, additional, Tseluyko, Vira, additional, Mostovoy, Yuriy, additional, Stanislavchuk, Mykola, additional, Kyiak, Yulian, additional, Karpenko, Yuriy, additional, Malynovsky, Yaroslav, additional, Klantsa, Andriy, additional, Kutniy, Oles, additional, Amosova, Ekaterina, additional, Tashchuk, Viktor, additional, Leshchuk, Oleh, additional, Rishko, Mykola, additional, Kopytsya, Mykola, additional, Yagensky, Andriy, additional, Vatutin, Mykola, additional, Bagriy, Andriy, additional, Barna, Olga M, additional, Ushakov, Olexiy, additional, Dzyak, Georgiy, additional, Goloborodko, Borys, additional, Rudenko, Anatolii, additional, Zheleznyy, Volodymyr, additional, Trevelyan, Jasper, additional, Zaman, Azfar, additional, Lee, Kaeng, additional, Moriarty, Andrew, additional, Aggarwal, Rajesh K, additional, Clifford, Piers, additional, Wong, Yuk-Ki, additional, Iqbal, Syed MR, additional, Subkovas, Eduardas, additional, Braganza, Denise, additional, Sarkar, David, additional, Storey, Robert, additional, Griffiths, Huw, additional, McClure, Sam, additional, Muthusamy, Rangasamy, additional, Smith, Simon, additional, Kurian, John, additional, Levy, Terry, additional, Barr, Craig, additional, Kadr, Honer, additional, Gerber, Robert, additional, Simaitis, Audrius, additional, Soran, Handrean, additional, Mathur, Anthony, additional, Brodison, Adrian, additional, Ayaz, Mohammad, additional, Cheema, Muhammad, additional, Oliver, Richard, additional, Thackray, Simon, additional, Mudawi, Telal, additional, Rahman, Gohar, additional, Sultan, Ayyaz, additional, Sharman, David, additional, Sprigings, David, additional, Butler, Rob, additional, Wilkinson, Peter, additional, Lip, Gregory YH, additional, Halcox, Julian, additional, Gallagher, Sean, additional, Ossei-Gerning, Nicholas, additional, Vardi, Gil, additional, Baldari, Duccio, additional, Brabham, David, additional, Treasure II, Charles, additional, Dahl, Charles, additional, Palmer, Bruce, additional, Wiseman, Alan, additional, Khan, Abul, additional, Puri, Sanjeev, additional, Mohart, Ann Elizabeth, additional, Ince, Carlos, additional, Flores, Enrique, additional, Wright, Scott, additional, Cheng, Shi-Chi, additional, Rosenberg, Michael, additional, Rogers, William, additional, Kosinski, Edward, additional, Forgosh, Les, additional, Waltman, Jonathan, additional, Khan, Misal, additional, Shoukfeh, Mohammad, additional, Dagher, Georges, additional, Cambier, Patrick, additional, Lieber, Ira, additional, Kumar, Priya, additional, East, Cara, additional, Krichmar, Perry, additional, Hasan, Mian, additional, White, Lindsey, additional, Knickelbine, Thomas, additional, Haldis, Thomas, additional, Gillespie, Eve, additional, Amidon, Thomas, additional, Suh, David, additional, Arif, Imran, additional, Abdallah, Mouhamad, additional, Akhter, Faiq, additional, Carlson, Eric, additional, D'Urso, Michael, additional, El-Ahdab, Fadi, additional, Nelson, William, additional, Moriarty, Katie, additional, Harris, Barry, additional, Cohen, Steven, additional, Carter, Luther, additional, Doty, Daniel, additional, Sabatino, Kenneth, additional, Haddad, Tariq, additional, Malik, Amir, additional, Rao, Sunder, additional, Mulkay, Angel, additional, Jovin, Ion, additional, Klancke, Kim, additional, Malhotra, Vinay, additional, Devarapalli, Sai K, additional, Koren, Michael, additional, Chandna, Harish, additional, Dodds III, George, additional, Goraya, Tauqir, additional, Bengston, James, additional, Janik, Matthew, additional, Moran, Joseph, additional, Sumner, Andrew, additional, Kobayashi, John, additional, Davis, William, additional, Yazdani, Shahram, additional, Pasquini, John, additional, Thakkar, Maitreya, additional, Vedere, Amarnath, additional, Leimbach, Wayne, additional, Rider, James, additional, Fenton, Sarah, additional, Singh, Narendra, additional, Shah, Anil V, additional, Janosik, Denise, additional, Pepine, Carl, additional, Berman, Brett, additional, Gelormini, Joseph, additional, Daniels, Christopher, additional, Richard, Kerensky, additional, Keating, Friederike, additional, Kondo, Nicholas I, additional, Shetty, Sanjay, additional, Levite, Howard, additional, Waider, Winfried, additional, Takata, Theodore, additional, Abu-Fadel, Mazen, additional, Shah, Vipul, additional, Aggarwal, Rahul, additional, Izzo, Mark, additional, Kumar, Anil, additional, Hattler, Brack, additional, Do, Rose, additional, Link, Chad, additional, Bortnick, Anna, additional, Kinzfogl III, George, additional, Ghitis, Arnold, additional, Larry, John, additional, Teufel, Edward, additional, Kuhlman, Peter, additional, Mclaurin, Brent, additional, Zhang, Wenwu, additional, Thew, Stephen, additional, Abbas, Jalal, additional, White, Matthew, additional, Islam, Othman, additional, Subherwal, Sumeet, additional, Ranadive, Nandkishore, additional, Vakili, Babak, additional, Gring, Christian, additional, Henderson, David, additional, Schuchard, Timothy, additional, Farhat, Naim, additional, Kline, Geoffrey, additional, Mahal, Sharan, additional, Whitaker, Jack, additional, Speirs, Shawn, additional, Andersen, Rolf, additional, Daboul, Nizar, additional, Horwitz, Phillip, additional, Zahr, Firas, additional, Ponce, George, additional, Jafar, Zubair, additional, Mcgarvey, Joseph, additional, Panchal, Vipul, additional, Voyce, Stephen, additional, Blok, Thomas, additional, Sheldon, William, additional, Azizad, Masoud M, additional, Schmalfuss, Carsten, additional, Picone, Mark, additional, Pederson, Robert, additional, Herzog, William, additional, Friedman, Keith, additional, Lindsey, Jason, additional, Nowins, Rosemary, additional, Timothy, Eichenlaub, additional, Leonard, Parilak, additional, Lepor, Norman, additional, El Shahawy, Mahfouz, additional, Weintraub, Howard, additional, Irimpen, Anand, additional, Alonso, Alvaro, additional, May, Wade, additional, Christopher, Daniels, additional, Galski, Thomas, additional, Chu, Alan, additional, Mody, Freny, additional, Ramin, Ebrahimi, additional, Hodes, Zachary, additional, Rossi, Joseph, additional, Rose, Gregory, additional, Fairlamb, James, additional, Lambert, Charles, additional, Raisinghani, Ajit, additional, Abbate, Antonio, additional, Vetrovec, George, additional, King, Marilyn, additional, Carey, Charles, additional, Gerber, Jaime, additional, Younis, Liwa, additional, Park, Hyeun (Tom), additional, Vidovich, Mladen, additional, Knutson, Thomas, additional, Friedman, Dennis, additional, Chaleff, Fred, additional, Loussararian, Arthur, additional, Rozeman, Phillip, additional, Kimmelstiel, Carey, additional, Kuvin, Jeffrey, additional, Silver, Kevin, additional, Foster, Malcolm, additional, Tonnessen, Glen, additional, Espinoza, Andrey, additional, Amlani, Mohamadali, additional, Wali, Andreas, additional, Malozzi, Christopher, additional, Jong, Geert T, additional, Massey, Clara, additional, Wattanakit, Keattiyoat, additional, O'Donnell, Philip J., additional, Singal, Dinesh, additional, Jaffrani, Naseem, additional, Banuru, Sridhar, additional, Fisher, Daniel, additional, Xenakis, Mark, additional, Perlmutter, Neal, additional, Bhagwat, Ravi, additional, Strader, James, additional, Blonder, Ronald, additional, Akyea-Djamson, Ayim, additional, Labroo, Ajay, additional, Lee, Kwan, additional, Marais, H. John, additional, Claxton, Edmund, additional, Weiss, Robert, additional, Kathryn, Rohr, additional, Berk, Martin, additional, Rossi, Peter, additional, Joshi, Parag, additional, Khera, Amit, additional, Khaira, Ajit S, additional, Kumkumian, Greg, additional, Lupovitch, Steven, additional, Purow, Joshua, additional, Welka, Stephen, additional, Hoffman, David, additional, Fischer, Stuart, additional, Soroka, Eugene, additional, Eagerton, Donald, additional, Pancholy, Samir, additional, Ray, Michael, additional, Erenrich, Norman, additional, Farrar, Michael, additional, Pollock, Stewart, additional, French, William J, additional, Diamantis, Steve, additional, Guy, Douglas, additional, Gimple, Lawrence, additional, Neustel, Mark, additional, Schwartz, Steven, additional, Pereira, Edward, additional, Albert, Seals, additional, Spriggs, Douglas, additional, Strain, Janet, additional, Mittal, Suneet, additional, Vo, Anthony, additional, Chane, Majed, additional, Hall, Jason, additional, Vijay, Nampalli, additional, Lotun, Kapildeo, additional, Lester, F. Martin, additional, Nahhas, Ahed, additional, Pope, Theodore, additional, Nager, Paul, additional, Vohra, Rakesh, additional, Sharma, Mukesh, additional, Bashir, Riyaz, additional, Ahmed, Hinan, additional, Berlowitz, Michael, additional, Fishberg, Robert, additional, Barrucco, Robert, additional, Yang, Eric, additional, Radin, Michael, additional, Sporn, Daniel, additional, Stapleton, Dwight, additional, Eisenberg, Steven, additional, Landzberg, Joel, additional, Mcgough, Martin, additional, Turk, Samir, additional, Schwartz, Michael, additional, Sundram, P. Sandy, additional, Jain, Diwakar, additional, Zainea, Mark, additional, Bayron, Carlos, additional, Karlsberg, Ronald, additional, Dohad, Suhail, additional, Lui, Henry, additional, Keen, William, additional, Westerhausen, Donald, additional, Khurana, Sandeep, additional, Agarwal, Himanshu, additional, Birchem, Jessica, additional, Penny, William, additional, Chang, Mark, additional, Murphy, Sherrill, additional, Henry, John, additional, Schifferdecker, Branislav, additional, Gilbert, John M, additional, Chalavarya, Gopal, additional, Eaton, Charles, additional, Schmedtje, John F, additional, Christenson, Stuart, additional, Dotani, Imran, additional, Denham, Douglas, additional, Macdonell, Alexander, additional, Gibson, Paul, additional, Rahman, Aref, additional, Al Joundi, Tammam, additional, Assi, Nizar, additional, Conrad, Gary, additional, Kotha, Purushotham, additional, Love, Michael, additional, Giesler, Gregory, additional, Rubenstein, Howard, additional, Gamil, Dawood, additional, Akright, Laura, additional, Krawczyk, Justine, additional, Cobler, Joanne, additional, Wells, Terry, additional, Welker, James, additional, Foster, Robert, additional, Gilmore, Richard, additional, Anderson, Jay, additional, Jacoby, Douglas, additional, Harris, Bill, additional, Gardner, Geraldine, additional, Dandillaya, Ramprasad, additional, Vora, Kishor, additional, Kostis, John, additional, Hunter, John, additional, Laxson, David, additional, Ball, Eric, additional, Lopes, Renato, additional, Egydio, Flavia, additional, Kawakami, Anelise, additional, Oliveira, Janaina, additional, Wozniak, Julianna, additional, Matthews, Alexander, additional, Ratky, Caroline, additional, Valiris, Janine, additional, Berdan, Lisa, additional, Hepditch, Anita, additional, Quintero, Kirby, additional, Rorick, Tyrus, additional, Westbrook, Melissa, additional, Pascual, Andrea, additional, Rovito, Carla, additional, Bezault, Madeleine, additional, Drouet, Elodie, additional, Simon, Tabassome, additional, Alsweiler, Caroline, additional, Luyten, Anne, additional, Butters, Julie, additional, Griffith, Liddy, additional, Shaw, Michelle, additional, Grunberg, Lena, additional, Islam, Shahidul, additional, Brégeault, Marie-France, additional, Bougon, Nathalie, additional, Faustino, Douglas, additional, Fontecave, Sylvie, additional, Murphy, Judith, additional, Verrier, Melanie, additional, Agnetti, Veronique, additional, Andersen, Dorthe, additional, Badreddine, Emmy, additional, Bekkouche, Mhamed, additional, Bouancheau, Cecile, additional, Brigui, Imane, additional, Brocklehurst, Maddy, additional, Cianciarulo, Joseph, additional, Devaul, Dawn, additional, Domokos, Szilvia, additional, Gache, Cecile, additional, Gobillot, Caroline, additional, Guillou, Severine, additional, Healy, Jan, additional, Heath, Megan, additional, Jaiwal, Gayatri, additional, Javierre, Carine, additional, Labeirie, Julien, additional, Monier, Myriam, additional, Morales, Ulises, additional, Mrabti, Asmaa, additional, Mthombeni, Bicky, additional, Okan, Betim, additional, Smith, Lucile, additional, Sheller, Jennifer, additional, Sopena, Sebastien, additional, Pellan, Valerie, additional, Benbernou, Fadela, additional, Bengrait, Nafissa, additional, Lamoureux, Maud, additional, Kralova, Katarina, additional, Scemama, Michel, additional, Bejuit, Raphael, additional, Coulange, Anthony, additional, Berthou, Christelle, additional, Repincay, Jérôme, additional, Lorenzato, Christelle, additional, Etienne, Alexis, additional, Gouet, Valerie, additional, Normand, Mickael, additional, Ourliac, Anne, additional, Rondel, Christelle, additional, Adamo, Antony, additional, Beltran, Pascale, additional, Barraud, Pauline, additional, Dubois-Gache, Helene, additional, Halle, Benjamin, additional, Metwally, Lamia, additional, Mourgues, Maxime, additional, Sotty, Marc, additional, Vincendet, Marion, additional, Cotruta, Raluca, additional, Chengyue, Zhu, additional, Fournie-Lloret, Dominique, additional, Morrello, Christine, additional, Perthuis, Aurelie, additional, Picault, Patrick, additional, Zobouyan, Isabelle, additional, Colhoun, Helen M., additional, Dempsey, Michael A., additional, and McClanahan, Mark A, additional

Published
2019
Full Text
View/download PDF

172. Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial

Author

Schwartz, Gregory G., Bessac, Laurence, Berdan, Lisa G., Bhatt, Deepak L., Bittner, Vera, Diaz, Rafael, Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, Wouter J., Mahaffey, Kenneth W., Moryusef, Angèle, Pordy, Robert, Roe, Matthew T., Rorick, Tyrus, Sasiela, William J., Shirodaria, Cheerag, Szarek, Michael, Tamby, Jean-François, Tricoci, Pierluigi, White, Harvey, Zeiher, Andreas, and Steg, Philippe Gabriel

Published
2014
Full Text
View/download PDF

174. Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome:ODYSSEY OUTCOMES Trial

Author

Jukema, J. Wouter, Szarek, Michael, Zijlstra, Laurien E., de Silva, H. Asita, Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Karpov, Yuri, Moryusef, Angle, Pordy, Robert, Prieto, Juan C., Roe, Matthew T., White, Harvey D., Zeiher, Andreas M., Schwartz, Gregory G., Steg, P. Gabriel, Clemmensen, Peter, Gislason, Gunnar, Davidsen, Flemming, Videbaek, Lars, and Andersen, Dorthe

Subjects
death, alirocumab, peripheral artery disease, major adverse cardiac events, acute coronary syndrome, cerebrovascular disease
Abstract

Background: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin–kexin type 9 inhibition in such patients is undetermined. Objectives: This pre-specified analysis from ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) determined whether polyvascular disease influenced risks of MACEs and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy. Methods: Patients were randomized to alirocumab or placebo 1 to 12 months after ACS. The primary MACEs endpoint was the composite of coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. Results: Median follow-up was 2.8 years. Of 18,924 patients, 17,370 had monovascular (coronary) disease, 1,405 had polyvascular disease in 2 beds (coronary and peripheral artery or cerebrovascular), and 149 had polyvascular disease in 3 beds (coronary, peripheral artery, cerebrovascular). With placebo, the incidence of MACEs by respective vascular categories was 10.0%, 22.2%, and 39.7%. With alirocumab, the corresponding absolute risk reduction was 1.4% (95% confidence interval [CI]: 0.6% to 2.3%), 1.9% (95% CI: −2.4% to 6.2%), and 13.0% (95% CI: −2.0% to 28.0%). With placebo, the incidence of death by respective vascular categories was 3.5%, 10.0%, and 21.8%; the absolute risk reduction with alirocumab was 0.4% (95% CI: −0.1% to 1.0%), 1.3% (95% CI: −1.8% to 4.3%), and 16.2% (95% CI: 5.5% to 26.8%). Conclusions: In patients with recent ACS and dyslipidemia despite intensive statin therapy, polyvascular disease is associated with high risks of MACEs and death. The large absolute reductions in those risks with alirocumab are a potential benefit for these patients. (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab [ODYSSEY OUTCOMES]: NCT01663402)

Published
2019

175. Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome ODYSSEY OUTCOMES Trial

Author

Jukema, J Wouter, Szarek, Michael, Zijlstra, Laurien E, de Silva, H Asita, Bhatt, Deepak L, Bittner, Vera A, Diaz, Rafael, Edelberg, Jay M, Goodman, Shaun G, Hanotin, Corinne, Harrington, Robert A, Karpov, Yuri, Moryusef, Angle, Pordy, Robert, Prieto, Juan C, Roe, Matthew T, White, Harvey D, Zeiher, Andreas M, Schwartz, Gregory G, Steg, P Gabriel, Tricoci, Pierluigi, Mahaffey, Kenneth W, Lecorps, Guillaume, Moryusef, Angele, Sasiela, William J, Tamby, Jean-Francois, Aylward, Philip E, Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Gotcheva, Nina N, Prieto, Juan-Carlos, Yong, Huo, Lopez-Jaramillo, Patricio, Pecin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S, Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Valdovinos, Pablo Carlos Montenegro, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Kedev, Sasko, Erglis, Andrejs, Laucevicius, Aleksandras, Yusoff, Khalid, Lopez, Ramos, Ramos Lopez, Gabriel Arturo, Alings, Marco, Halvorsen, Sigrun, Correa Flores, Roger M, Sy, Rody G, Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Ristic, Arsen D, Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J, Tunon, Jose, Hagstrom, Emil, Muller, Christian, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K, Moriarty, Patrick M, Chaitman, Bernard, Kelsey, Sheryl F, Olsson, Anders G, Rouleau, Jean-Lucien, Simoons, Maarten L, Alexander, Karen, Meloni, Chiara, Rosenson, Robert, Sijbrands, Eric JG, Alexander, John H, Armaganijan, Luciana, Bagai, Akshay, Bahit, Maria Cecilia, Brennan, J Matthew, Clifton, Shaun, DeVore, Adam D, Deloatch, Shalonda, Dickey, Sheila, Dombrowski, Keith, Ducrocq, Gregory, Eapen, Zubin, Endsley, Patricia, Eppinger, Arleen, Harrison, Robert W, Hess, Connie Ng, Hlatky, Mark A, Jordan, Joseph Dedrick, Knowles, Joshua W, Kolls, Bradley J, Kong, David F, Leonardi, Sergio, Lillis, Linda, Maron, David J, Marcus, Jill, Mathews, Robin, Mehta, Rajendra H, Mentz, Robert J, Moreira, Humberto Graner, Patel, Chetan B, Pereira, Sabrina Bernardez, Perkins, Lynn, Povsic, Thomas J, Puymirat, Etienne, Jones, William Schuyler, Shah, Bimal R, Sherwood, Matthew W, Stringfellow, Kenya, Sujjavanich, Darin, Toma, Mustafa, Van Diepen, Sean FP, Wilson, Matthew D, Yan, Andrew Tze-Kay, Lopes, Renato D, Trotter, Charlene, Schiavi, Lilia B, Garrido, Marcelo, Alvarisqueta, Andres F, Sassone, Sonia A, Bordonava, Anselmo P, Alves De Lima, Alberto E, Schmidberg, Jorge M, Duronto, Ernesto A, Caruso, Orlando C, Novaretto, Leonardo P, Angel Hominal, Miguel, Montana, Oscar R, Caccavo, Alberto, Gomez Vilamajo, Oscar A, Lorenzatti, Alberto J, Cartasegna, Luis R, Paterlini, Gustavo A, Mackinnon, Ignacio J, Caime, Guillermo D, Amuchastegui, Marcos, Salomone, Rodolfo, Codutti, Oscar R, Jure, Horacio O, Bono, Julio OE, Hrabar, Adrian D, Vallejos, Julio A, Ahuad Guerrero, Rodolfo A, Novoa, Federico, Patocchi, Cristian A, Zaidman, Cesar J, Giuliano, Maria E, Dran, Ricardo D, Vico, Marisa L, Carnero, Gabriela S, Guzman, Pablo N, Medrano Allende, Juan C, Garcia Brasca, Daniela F, Bustamante Labarta, Miguel H, Nani, Sebastian, Blumberg, Eduardo DS, Colombo, Hugo R, Liberman, Alberto, Luciardi, Hector L, Waisman, Gabriel D, Berli, Mario A, Duran, Ruben O Garcia, Cestari, Horacio G, Luquez, Hugo A, Giordano, Jorge A, Saavedra, Silvia S, Zapata, Gerardo, Costamagna, Osvaldo, Llois, Susana, Waites, Jonathon H, Collins, Nicholas, Soward, Allan, Hii, Chris LS, Shaw, James, Arstall, Margaret A, Horowitz, John, Rogers, James F, Colquhoun, David, Oqueli Flores, Romulo E, Roberts-Thomson, Philip, Raffel, Owen, Lehman, Sam J, Aroney, Constantine, Coverdale, Steven GM, Garrahy, Paul J, Starmer, Gregory, Sader, Mark, Carroll, Patrick A, Dick, Ronald, Zweiker, Robert, Hoppe, Uta, Huber, Kurt, Berger, Rudolf, Weidinger, Franz, Faes, Dirk, Hermans, Kurt, Pirenne, Bruno, Leone, Attilio, Hoffer, Etienne, Vrolix, Mathias CM, De Wolf, Luc, Wollaert, Bart, Castadot, Marc, Dujardin, Karl, Beauloye, Christophe, Vervoort, Geert, Striekwold, Harry, Convens, Carl, Roosen, John, Barbato, Emanuele, Claeys, Marc, Cools, Frank, Terzic, Ibrahim, Barakovic, Fahir, Midzic, Zlatko, Pojskic, Belma, Fazlibegovic, Emir, Durak-Nalbantic, Azra, Vulic, Dusko, Muslibegovic, Adis, Goronja, Boris, Reis, Gilmar, Sousa, Luciano, Nicolau, Jose C, Giorgeto, Flavio E, Silva, Ricardo P, Maia, Lilia Nigro, Rech, Rafael, Rossi, Paulo RF, Cerqueira, Maria Jose AG, Duda, Norberto, Kalil, Renato, Kormann, Adrian, Abrantes, Jose Antonio M, Pimentel Filho, Pedro, Soggia, Ana Priscila, de Santos, Mayler ON, Neuenschwander, Fernando, Bodanese, Luiz C, Michalaros, Yorghos L, Eliaschewitz, Freddy G, Vidotti, Maria H, Leaes, Paulo E, Botelho, Roberto V, Kaiser, Sergio, Fernandes Manenti, Euler Roberto F, Precoma, Dalton B, Moura Jorge, Jose C, Silva, Pedro GM de B, Silveira, Jose A, Saporito, Wladmir, Marin Neto, Jose A, Feitosa, Gilson S, Ritt, Luiz Eduardo F, de Souza, Juliana A, Costa, Fernando, Souza, Weimar KSB, Reis, Helder JL, Machado, Leandro, Aidar Ayoub, Jose Carlos, Todorov, Georgi V, Nikolov, Fedya P, Velcheva, Elena S, Tzekova, Maria L, Benov, Haralambi O, Petranov, Stanislav L, Tumbev, Haralin S, Shehova-Yankova, Nina S, Markov, Dimitar T, Raev, Dimitar H, Mollov, Mihail N, Kichukov, Kostadin N, Ilieva-Pandeva, Katya A, Ivanova, Raya, Mincheva, Valentina M, Lazov, Petar V, Dimov, Bojidar I, Senaratne, Manohara, Stone, James, Kornder, Jan, Pearce, Stephen, Dion, Danielle, Savard, Daniel, Pesant, Yves, Pandey, Amritanshu, Robinson, Simon, Gosselin, Gilbert, Vizel, Saul, Hoag, Gordon, Bourgeois, Ronald, Morisset, Anne, Sabbah, Eric, Sussex, Bruce, Kouz, Simon, MacDonald, Paul, Diaz, Ariel, Michaud, Nicolas, Fell, David, Leung, Raymond, Vuurmans, Tycho, Lai, Christopher, Nigro, Frank, Davies, Richard, Nogareda, Gustavo, Vijayaraghavan, Ram, Ducas, John, Lepage, Serge, Mehta, Shamir, Cha, James, Dupuis, Robert, Fong, Peter, Rodes-Cabau, Josep, Fadlallah, Hussein, Cleveland, David, Thao, Huynh, Bata, Iqbal, Hameed, Adnan, Pincetti, Cristian, Potthoff, Sergio, Acevedo, Monica, Aguirre, Arnoldo, Vejar, Margarita, Yanez, Mario, Araneda, Guillermo, Fernandez, Mauricio, Perez, Luis, Varleta, Paola, Florenzano, Fernando, Huidobro, Laura, Raffo, Carlos A, Olivares, Claudia, Nahuelpan, Leonardo, Montecinos, Humberto, Chen, Jiyan, Dong, Yugang, Huang, Weijian, Wang, Jianzhong, Huang, Shi'An, Yao, Zhuhua, Li, Xiang, Cui, Lan, Lin, Wenhua, Sun, Yuemin, Wang, Jingfeng, Li, Jianping, Zhang, Xuelian, Zhu, Hong, Chen, Dandan, Huang, Lan, Dong, Shaohong, Su, Guohai, Xu, Biao, Su, Xi, Cheng, Xiaoshu, Lin, Jinxiu, Zong, Wenxia, Li, Huanming, Feng, Yi, Xu, Dingli, Yang, Xinchun, Ke, Yuannan, Lin, Xuefeng, Zhang, Zheng, Zheng, Zeqi, Luo, Zhurong, Chen, Yundai, Ding, Chunhua, Zheng, Yang, Li, Xiaodong, Peng, Daoquan, Li, Ying, Wei, Meng, Liu, Shaowen, Yu, Yihua, Qu, Baiming, Jiang, Weihong, Zhou, Yujie, Zhao, Xingsheng, Yuan, Zuyi, Guo, Ying, Xu, Xiping, Shi, Xubo, Ge, Junbo, Fu, Guosheng, Bai, Feng, Fang, Weiyi, Shou, Xiling, Yang, Xiangjun, Wang, Jian'An, Sun, Yingxian, Lu, Qinghua, Zhang, Ruiyan, Zhu, Jianhua, Xu, Yizhou, Fan, Zhongcai, Li, Tianchang, Wu, Chun, Jaramillo, Nicolas, Vallejo, Gregorio Sanchez, Botia, Diana C Luna, Lopez, Rodrigo Botero, De Salazar, Dora I Molina, Bonfanti, Alberto J Cadena, Higuera, Juan Diego, Silva, Sandra I Barrera, Lozada, Henry J Garcia, Arroyo, Julian A Coronel, Mendoza, Jose L Accini, Ruiz, Ricardo L Fernandez, Jatin, Fernando G Manzur, Herazo, Aristides Sotomayor, Parada, Jeffrey Castellanos, Triana, Miguel A Urina, Strozzi, Maja, Car, Sinisa, Milicic, Davor, Bencic, Martina Lovric, Pintaric, Hrvoje, Prvulovic, Deiti, Sikic, Jozica, Persic, Viktor, Mileta, Dean, Stambuk, Kresimir, Zdravko, Babic, Tomulic, Vjekoslav, Krstulovic, Stanka Mejic, Starcevic, Boris, Spinar, Jindrich, Horak, David, Stasek, Josef, Alan, David, Machova, Vilma, Linhart, Ales, Novotny, Vojtech, Kaucak, Vladimir, Rokyta, Richard, Naplava, Robert, Coufal, Zdenek, Adamkova, Vera, Podpera, Ivo, Zizka, Jiri, Motovska, Zuzana, Marusincova, Ivana, Svab, Premysl, Heinc, Petr, Kuchar, Jiri, Povolny, Petr, Matuska, Jiri, Raungaard, Bent, Clemmensen, Peter, Bang, Lia E, May, Ole, Bottcher, Morten, Hove, Jens D, Frost, Lars, Gislason, Gunnar, Larsen, John, Johansen, Peter Betton, Hald, Flemming, Jeppesen, Jorgen, Nielsen, Tonny, Kristensen, Kjeld S, Walichiewicz, Piotr Maria, Lomholdt, Jens D, Klausen, Ib C, Nielsen, Peter Kaiser, Davidsen, Flemming, Videbaek, Lars, Soots, Mai, Vahula, Veiko, Hedman, Anu, Soopold, Ullar, Martsin, Kaja, Kristjan, Arved, Taskinen, Marja-Riitta, Porthan, Kimmo, Airaksinen, Juhani K, Juonala, Markus, Kiviniemi, Tuomas, Vikman, Saila, Posio, Pirjo, Taurio, Jyrki, Huikuri, Heikki, Kaikkonen, Kari, Coste, Pierre, Ferrari, Emile, Morel, Olivier, Montalescot, Gilles, Barone-Rochette, Gilles, Mansourati, Jacques, Cottin, Yves, Leclercq, Florence, Belhassane, Abdelkader, Delarche, Nicolas, Boccara, Franck, Paganelli, Franck, Clerc, Jerome, Schiele, Francois, Aboyans, Victor, Probst, Vincent, Berland, Jacques, Lefevre, Thierry, Citron, Bernard, Khintibidze, Irakli, Shaburishvili, Tamaz, Pagava, Zurab, Ghlonti, Ramaz, Lominadze, Zaza, Khabeishvili, George, Hemetsberger, Rayyan, Rauch-Kroehnert, Ursula, Stratmann, Matthias, Appel, Karl-Friedrich, Schmidt, Ekkehard, Omran, Heyder, Stellbrink, Christoph, Dorsel, Thomas, Lianopoulos, Emmanouil, Marx, Roger, Zirlik, Andreas, Schellenberg, Detlev, Heitzer, Thomas, Laufs, Ulrich, Gielen, Stephan, Winkelmann, Bernhard, Behrens, Steffen, Sydow, Karsten, Simonis, Gregor, Muenzel, Thomas, Werner, Nikos, Leggewie, Stefan, Boecker, Dirk, Braun-Dullaeus, Ruediger, Toursarkissian, Nicole, Jeserich, Michael, Weissbrodt, Matthias, Schaeufele, Tim, Weil, Joachim, Voeller, Heinz, Waltenberger, Johannes, Natour, Mohammed, Schmitt, Susanne, Steiner, Stephan, Heidenreich, Lothar, Gremmler, Uwe, Killat, Holger, Rieker, Werner, Patsilinakos, Sotiris, Kartalis, Athanasios, Manolis, Athanassios, Sionis, Dimitrios, Skoumas, Ioannis, Athyros, Vasilios, Vardas, Panagiotis, Parthenakis, Frangkiskos, Alexopoulos, Dimitrios, Hahalis, Georgios, Lekakis, John, Hatzitolios, Apostolos, Ovando, Sergio R Fausto, Benecke, Juan L Arango, De Leon, Edgar R Rodriguez, Yan, Bryan PY, Siu, David CW, Turi, Tibor, Merkely, Bela, Ungi, Imre, Lupkovics, Geza, Nagy, Lajos, Katona, Andras, Edes, Istvan, Muller, Gabor, Horvath, Ivan, Kapin, Tibor, Falukozy, Jozsef, Kumbla, Mukund, Sandhu, Manjinder, Annam, Sharath, Proddutur, Naveen Reddy, Premchand, Rajendra K, Mahajan, Ajaykumar, Abhyanakar, Atul D, Kerkar, Prafulla, Govinda, Ravishankar A, Oomman, Abraham, Sinha, Dhurjati, Patil, Sachin N, Kahali, Dhiman, Sawhney, Jitendra, Joshi, Abhijeet B, Chaudhary, Sanjeev, Harkut, Pankaj, Guha, Santanu, Porwal, Sanjay, Jujjuru, Srimannarayana, Pothineni, Ramesh B, Monteiro, Minguel R, Khan, Aziz, Iyengar, Shamanna S, Grewal, Jasprakash Singh, Chopda, Manoj, Fulwani, Mahesh C, Patange, Aparna, Chopra, Vijay K, Goyal, Naresh K, Shinde, Rituparna, Manakshe, Gajendra V, Patki, Nitin, Sethi, Sumeet, Munusamy, Vengatesh, Karna, Sunil, Adhyapak, Srilakshmi, Pandurangi, Ulhas, Mathur, Rishabh, Kalashetti, Suhas, Bhagwat, Ajit, Raghuraman, Bagirath, Yerra, Shiv Kumar, Bhansali, Prasant, Borse, Rohidas, Das, Srihari, Abdullakutty, Jabir, Saathe, Shireesh, Palimkar, Priya, Abdullkutty, Jabir, Sathe, Shireesh, Atar, Shaul, Shechter, Michael, Mosseri, Morris, Arbel, Yaron, Lotan, Chaim, Rosenschein, Uri, Katz, Amos, Henkin, Yaakov, Francis, Adi, Klutstein, Marc, Nikolsky, Eugenia, Turgeman, Yoav, Halabi, Majdi, Kornowski, Ran, Jonas, Michael, Amir, Offer, Rozenman, Yoseph, Fuchs, Shmuel, Hussein, Osamah, Gavish, Dov, Vered, Zvi, Caraco, Yoseph, Elias, Mazen, Tov, Naveh, Lishner, Michael, Elias, Nizar, Piovaccari, Giancarlo, De Pellegrin, Annamaria, Guardigli, Gabriele, Licciardello, Giovanni, Auguadro, Carla, Cuccia, Claudio, Salvioni, Alessandro, Musumeci, Giuseppe, Calabro, Paolo, Novo, Salvatore, Faggiano, Pompilio, De Cesare, Nicoletta B, Berti, Sergio, Cavallini, Claudio, Puccioni, Enrico, Galvani, Marcello, Tespili, Maurizio, Piatti, Piermarco, Palvarini, Michela, De Luca, Giuseppe, Violini, Roberto, De Leo, Alessandro, Filardi, Pasquale Perrone, Ferratini, Maurizio, Ricca, Vittorio, Dai, Kazuoki, Kamiya, Haruo, Ando, Kenji, Takeda, Yoshihiro, Morino, Yoshihiro, Hata, Yoshiki, Kimura, Kazuo, Kishi, Koichi, Michishita, Ichiro, Uehara, Hiroki, Higashikata, Toshinori, Hirayama, Atsushi, Hirooka, Keiji, Sakagami, Satoru, Taguchi, Shuichi, Koike, Akihiro, Fujinaga, Hiroyuki, Koba, Shinji, Kozuma, Ken, Kawasaki, Tomohiro, Ono, Yujiro, Shimizu, Masatoshi, Katsuda, Yousuke, Wada, Atsuyuki, Shinke, Toshiro, Ako, Junya, Fujii, Kenshi, Takahashi, Toshiyuki, Sakamoto, Tomohiro, Furukawa, Yutaka, Sugino, Hiroshi, Mano, Toshiaki, Utsu, Noriaki, Ito, Kashima, Haraguchi, Takuya, Ueda, Yasunori, Nishibe, Akira, Fujimoto, Kazuteru, Masutani, Motomaru, Yoon, Jung Han, Park, Hun Sik, Chae, In-Ho, Kim, Moo Hyun, Jeong, Myung Ho, Rha, Seungwoon, Kim, Chongjin, Kim, Hyo-Soo, Hong, Taekjong, Tahk, Seung-Jea, Kim, Youngkwon, Busmane, Arija, Pontaga, Natalija, Strelnieks, Aldis, Mintale, Iveta, Sime, Iveta, Petrulioniene, Zaneta, Kavaliauskiene, Roma, Jurgaitiene, Ruta, Sakalyte, Gintare, Slapikas, Rimvydas, Norkiene, Sigute, Misonis, Nerijus, Kibarskis, Aleksandras, Kubilius, Raimondas, Bojovski, Stojko, Lozance, Nensi, Kjovkaroski, Aleksandar, Doncovska, Snezana, Ong, Tiong Kiam, Kasim, Sazzli, Maskon, Oteh, Kandasamy, Balachandran, Liew, Houng B, Mohamed, Wan Mohd Izani Wan, Garcia Castillo, Armando, Carrillo Calvillo, Jorge, Fajardo Campos, Pedro, Nunez Fragoso, Juan Carlos, Bayram Llamas, Edmundo Alfredo, Alcocer Gamba, Marco Antonio, Carranza Madrigal, Jaime, Gonzalez Salas, Luis Gerardo, Lopez Rosas, Enrique, Gonzalez Diaz, Belinda, Salcido Vazquez, Eduardo, Nacoud Ackar, Alfredo, Llamas Esperon, Guillermo Antonio, Martinez Sanchez, Carlos Rodolfo, Guerrero De Leon, Maria, Suarez Otero, Rodrigo, Fanghanel Salmon, Guillermo, Perez Rios, Jesus Antonio, Garza Ruiz, Jose Angel, Breedveld, Robert W, Hoogslag, Pieter AM, Suryapranata, Harry, Oomen, Antonius, Wiersma, Jacobijne J, Van Der Wal, Ruud MA, Van Huysduynen-Monraats, Pascalle S Hooft, Karalis, Ioannis, Verdel, Gerardus JE, Brueren, Bart RG, Troquay, Roland PTh, Viergever, Eric P, Al-Windy, Nadea YY, Bartels, Gerard L, Cornel, Jan H, Hermans, Walter RM, Herrman, Johannes PR, Bos, Robert J, Groutars, Reginald GEJ, Van Der Zwaan, Coenraad C, Kaplan, Refik, Ronner, Eelko, Groenemeijer, Bjorn E, Bronzwaer, Patrick NA, Liem, Anho AH, Rensing, Bernard JWM, Bokern, Marcel JJA, Nijmeijer, Remco, Hersbach, Ferry MRJ, Willems, Frank F, Gosselink, Antonius TM, Elliott, John, Wilkins, Gerard, Fisher, Raewyn, Scott, Douglas, Hart, Hamish, Stewart, Ralph, Harding, Scott, Ternouth, Ian, Fisher, Nicholas, Aitken, Denise, Anscombe, Russell, Davidson, Laura, Tomala, Tadeusz, Nygard, Ottar, Sparby, Jon Arne, Andersen, Kjell, Gullestad, Lars, Jortveit, Jarle, Munk, Peter S, Singsaas, Erlend Gyllensten, Hurtig, Ulf, Calderon Ticona, Jorge R, Durand Velasquez, Julio R, Negron Miguel, Sandra A, Sanabria Perez, Enrique S, Carrion Chambilla, Jesus M, Chavez Ayala, Carlos A, Castillo Leon, Reynaldo P, Vargas Gonzales, Rolando J, Hernandez Zuniga, Jose D, Camacho Cosavalente, Luis A, Bravo Mannucci, Jorge E, Heredia Landeo, Javier, Llerena Navarro, Nassip C, Roldan Concha, Yudy M, Rodriguez Chavez, V-ctor E, Anchante Hernandez, Henry A, Zea Nunez, Carlos A, Mogrovejo Ramos, Walter, Ferrolino, Arthur, Sy, Rosa Allyn G, Tirador, Louie, Matiga, Generoso, Coching, Raul Martin, Bernan, Alisa, Rogelio, Gregorio, Morales, Dante D, Tan, Edgar, Sulit, Dennis Jose, Wlodarczak, Adrian, Jaworska, Krystyna, Skonieczny, Grzegorz, Pawlowicz, Lidia, Wojewod, Pawel, Busz-Papiez, Benita, Bednarski, Janusz, Goch, Aleksander, Staneta, Pawel, Dulak, Elzbieta, Saminsk, Krzysztof, Krasowski, Wlodzimierz, Sudnik, Wanda, Zurakowski, Aleksander, Skorski, Marcin, Lysek, Roman, Miklaszewicz, Beata, Kubica, Jacek, Lipko, Jan Andrzej, Kostarska-Srokosz, Edyta, Piepiorka, Marek, Drzewiecka, Anna, Sciborski, Ryszard, Stasiewski, Arkadiusz, Blicharski, Tomasz, Bystryk, Leszek, Szpajer, Michal, Korol, Marek, Czerski, Tomasz, Mirek-Bryniarska, Ewa, Gniot, Jacek, Lubinski, Andrzej, Gorny, Jerzy, Franek, Edward, Raczak, Grzegorz, Szwed, Hanna, Monteiro, Pedro, Bastos, Jose Mesquita, Pereira, Helder H, Martins, Dinis, Seixo, Filipe, Mendonca, Carlos, Botelho, Ana, Minescu, Bogdan, Istratoaie, Octavian, Tesloianu, Dan N, Cristian, Gabriel, Podoleanu, Cristian GC, Constantinescu, Mircea CA, Bengus, Cristina M, Militaru, Constantin, Rosu, Doina, Parepa, Irinel R, Matei, Adrian V, Alexandru, Tom M, Coman, Ioan, Cioranu, Rodica Stanescu, Dimulescu, Doina, Shvarts, Yury, Orlikova, Olga, Kobalava, Zhanna, Barbarash, Olga L, Markov, Valentin, Lyamina, Nadezhda, Gordienko, Alexander, Zrazhevsky, Konstantin, Vishnevsky, Alexander Y, Gurevich, Victor, Stryuk, Raisa, Lomakin, Nikita V, Bokarev, Igor, Shalaev, Sergey, Khaisheva, Larisa, Chizhov, Petr, Viktorova, Inna, Osokina, Natalya, Akatova, Evgenia, Chumakova, Galina, Libov, Igor, Voevoda, Mikhail I, Tretyakova, Tatyana V, Baranov, Evgeny, Shustov, Sergey, Yakushin, Sergey, Gordeev, Ivan, Khasanov, Niiaz, Reshetko, Olga, Sotnikova, Tatiana, Molchanova, Olga, Nikolaev, Konstantin, Gapon, Liudmila, Baranova, Elena, Shogenov, Zaur, Kosmachova, Elena, Karpov, Yuriy, Povzun, Anton, Egorova, Liudmila, Tyrenko, Vadim V, Ivanov, Igor G, Kanorsky, Sergey, Simic, Dragan, Ivanovic, Nikola, Davidovic, Goran, Tasic, Nebojsa, Asanin, Milika R, Stojic, Stevo, Apostolovic, Svetlana R, Ilic, Stevan, Putnikovic, Biljana, Stankovic, Aleksandar, Arandjelovic, Aleksandra, Radovanovic, Slavica, Balinovac, Jovan, Dincic, Dragan V, Seferovic, Petar, Dodic, Slobodan, Dimkovic, Sinisa, Poh, Kian-Keong, Ong, Hean Yee, Micko, Karol, Nociar, Jan, Pella, Daniel, Fulop, Peter, Hranai, Marian, Palka, Juraj, Mazur, Juraj, Majercak, Ivan, Dzupina, Andrej, Fazekas, Frantisek, Gonsorcik, Jozef, Bugan, Viliam, Selecky, Juraj, Kamensky, Gabriel, Strbova, Jaroslava, Smik, Rudolf, Dukat, Andrej, Olexa, Peter, Zuran, Ivan, Poklukar, Janez, Suligoj, Natasa Cerni, Cevc, Matija, Cyster, Henry P, Ranjith, Naresh, Corbett, Clive, Bayat, Junaid, Makotoko, Ellen Makoali, Kapp, Ilse E, Basson, Matthys M de V, Lottering, Hanlie, Van Zyl, Louis J, Sebastian, Peter J, Pillay, Thayabran, Saaiman, Jan A, Commerford, Patrick J, Cassimjee, Soraya, Ebrahim, Iftikhar O, Sarvan, Mahomed, Mynhardt, Joseph H, Reuter, Helmuth, Moodley, Rajendran, Vida, Manuel, Cequier Fillat, Angel R, Peris, Vicente Bodi, Jimenez, Francisco Fuentes, Marin, Francisco, Cruz Fernandez, Jose M, Gil-Extremera, Blas, Diz, Fernando Worner, Garcia-Dorado, David, Iniguez, Andres, Tunon Fernandez, Jose, Gonzalez-Juanatey, Jose R, Fernandez Portales, Javier, Civeira Murillo, Fernando, Matas Pericas, Laia, Luis Zamorano, Jose, De Mora Martin, Manuel, Bruguera Cortada, Jordi, Alonso Martin, Joaquin J, De Berrazueta Fernandez, Jose R, Diaz Fernandez, Jose Francisco, Garcia Lledo, Jose Alberto, Cosin Sales, Juan, Botas Rodriguez, Javier, Gusi Tragant, Gabriel, Benedicto, Amparo, Gonzalez-Juanatey, Carlos, Camprubi Potau, Mercedes, Plaza Perez, Ignacio, Moris De La Tassa, Cesar, Loma-Osorio Rincon, Pablo, Balaguer Recena, Javier, Escudier, Juan M, Coca Payeras, Antonio, Alonso Orcajo, Norberto, Valdivielso, Pedro, Constantine, Godwin, Haniffa, Ruvaiz, Tissera, Nirmali, Amarasekera, Stanley, Fernando, Nimali, Jayawardena, Jayanthimala, Santharaj, Wijeyasingam, Ekanayaka, Ruvan, Mendis, Sepalika, Senaratne, Vajira, Mayurathan, Gnanamoorthy, Sirisena, Thilak, Rajapaksha, Ajantha, Herath, Jagath I, Amarasena, Naomali, Berglund, Stefan, Rasmanis, Gundars, Witt, Nils, Mourtzinis, Georgios, Nicol, Peter, Hansen, Ole, Romeo, Stefano, Jensen, Steen Agergaard, Torstensson, Ingemar, Ahremark, Ulf, Sundelin, Torbjorn, Moccetti, Tiziano, Mach, Francois, Binder, Ronald, Tsai, Wei-Chuan, Ueng, Kwo-Chang, Lai, Wen-Ter, Liu, Ming-En, Hwang, Juey-Jen, Yin, Wei-Hsian, Hsieh, I-Chang, Lin, Wei Hsiang, Kuo, Jen-Yuan, Huang, Tsuei-Yuan, Fang, Chih-Yuan, Kaewsuwanna, Pinij, Soonfuang, Wasant, Jintapakorn, Woravut, Sukonthasarn, Apichard, Wongpraparut, Nattawut, Sastravaha, Krisada, Sansanayudh, Nakarin, Kehasukcharoen, Wirash, Piyayotai, Dilok, Chotnoparatpat, Paiboon, Camsari, Ahmet, Kultursay, Hakan, Mutlu, Bulent, Ersanli, Murat, Demirtas, Mustafa, Kirma, Cevat, Ural, Ertan, Koldas, Lale, Karpenko, Oleksandr, Prokhorov, Alexander, Vakaluyk, Ihor, Myshanych, Halyna, Reshotko, Dmytro, Batushkin, Valeriy, Rudenko, Leonid, Kovalskyi, Ihor, Kushnir, Mykola, Tseluyko, Vira, Mostovoy, Yuriy, Stanislavchuk, Mykola, Kyiak, Yulian, Karpenko, Yuriy, Malynovsky, Yaroslav, Klantsa, Andriy, Kutniy, Oles, Amosova, Ekaterina, Tashchuk, Viktor, Leshchuk, Oleh, Rishko, Mykola, Kopytsya, Mykola, Yagensky, Andriy, Vatutin, Mykola, Bagriy, Andriy, Barna, Olga M, Ushakov, Olexiy, Dzyak, Georgiy, Goloborodko, Borys, Rudenko, Anatolii, Zheleznyy, Volodymyr, Trevelyan, Jasper, Zaman, Azfar, Lee, Kaeng, Moriarty, Andrew, Aggarwal, Rajesh K, Clifford, Piers, Wong, Yuk-Ki, Iqbal, Syed MR, Subkovas, Eduardas, Braganza, Denise, Sarkar, David, Storey, Robert, Griffiths, Huw, Mcclure, Sam, Muthusamy, Rangasamy, Kurian, John, Levy, Terry, Barr, Craig, Kadr, Honer, Gerber, Robert, Simaitis, Audrius, Soran, Handrean, Mathur, Anthony, Brodison, Adrian, Oliver, Richard, Mudawi, Telal, Reynolds, Timothy, Sharman, David, Butler, Rob, Wilkinson, Peter, Lip, Gregory YH, Halcox, Julian, Vardi, Gil, Baldari, Duccio, Brabham, David, Treasure, Charles, Dahl, Charles, Palmer, Bruce, Wiseman, Alan, Khan, Abul, Puri, Sanjeev, Mohart, Ann Elizabeth, Ince, Carlos, Flores, Enrique, Wright, Scott, Cheng, Shi-Chi, Rosenberg, Michael, Rogers, William, Kosinski, Edward, Forgosh, Les, Waltman, Jonathan, Khan, Misal, Shoukfeh, Mohammad, Dagher, Georges, Lieber, Ira, Kumar, Priya, East, Cara, Krichmar, Perry, White, Lindsey, Knickelbine, Thomas, Haldis, Thomas, Gillespie, Eve, Suh, David, Arif, Imran, Akhter, Faiq, Carlson, Eric, D'Urso, Michael, El-Ahdab, Fadi, Nelson, William, Harris, Barry, Cohen, Steven, Carter, Luther, Sabatino, Kenneth, Haddad, Tariq, Malik, Amir, Rao, Sunder, Mulkay, Angel, Jovin, Ion, Klancke, Kim, Malhotra, Vinay, Devarapalli, Sai K, Koren, Michael, Chandna, Harish, Dodds, George, Janik, Matthew, Moran, Joseph, Sumner, Andrew, Kobayashi, John, Davis, William, Yazdani, Shahram, Pasquini, John, Thakkar, Maitreya, Vedere, Amarnath, Leimbach, Wayne, Rider, James, Singh, Narendra, Shah, Anil V, Janosik, Denise, Pepine, Carl, Berman, Brett, Gelormini, Joseph, Daniels, Christopher, Keating, Friederike, Kondo, Nicholas I, Shetty, Sanjay, Waider, Winfried, Takata, Theodore, Abu-Fadel, Mazen, Shah, Vipul, Aggarwal, Rahul, Izzo, Mark, Kumar, Anil, Hattler, Brack, Link, Chad, Bortnick, Anna, Kinzfogl, George, Ghitis, Arnold, Larry, John, Teufel, Edward, Kuhlman, Peter, Mclaurin, Brent, Zhang, Wenwu, Thew, Stephen, Abbas, Jalal, White, Matthew, Ranadive, Nandkishore, Gring, Christian, Henderson, David, Schuchard, Timothy, Farhat, Naim, Kline, Geoffrey, Mahal, Sharan, Whitaker, Jack, Speirs, Shawn, Andersen, Rolf, Daboul, Nizar, Horwitz, Phillip, Ponce, George, Jafar, Zubair, Mcgarvey, Joseph, Panchal, Vipul, Voyce, Stephen, Blok, Thomas, Sheldon, William, Azizad, Masoud M, Schmalfuss, Carsten, Picone, Mark, Herzog, William, Lindsey, Jason, Nowins, Rosemary, Lepor, Norman, El Shahawy, Mahfouz, Weintraub, Howard, Irimpen, Anand, May, Wade, Galski, Thomas, Chu, Alan, Mody, Freny, Hodes, Zachary, Rose, Gregory, Fairlamb, James, Lambert, Charles, Raisinghani, Ajit, Abbate, Antonio, King, Marilyn, Carey, Charles, Gerber, Jaime, Younis, Liwa, Park, Hyeun Tom, Vidovich, Mladen, Knutson, Thomas, Friedman, Dennis, Chaleff, Fred, Loussararian, Arthur, Rozeman, Phillip, Kimmelstiel, Carey, Silver, Kevin, Foster, Malcolm, Tonnessen, Glen, Amlani, Mohamadali, Wali, Andreas, Malozzi, Christopher, Wattanakit, Keattiyoat, O'Donnell, Philip J, Singal, Dinesh, Jaffrani, Naseem, Banuru, Sridhar, Fisher, Daniel, Xenakis, Mark, Perlmutter, Neal, Bhagwat, Ravi, Strader, James, Akyea-Djamson, Ayim, Labroo, Ajay, Lee, Kwan, Marais, H John, Claxton, Edmund, Berk, Martin, Rossi, Peter, Joshi, Parag, Khaira, Ajit S, Kumkumian, Greg, Lupovitch, Steven, Purow, Joshua, Welka, Stephen, Hoffman, David, Fischer, Stuart, Soroka, Eugene, Eagerton, Donald, Pancholy, Samir, Ray, Michael, Farrar, Michael, Pollock, Stewart, French, William J, Diamantis, Steve, Gimple, Lawrence, Neustel, Mark, Schwartz, Steven, Pereira, Edward, Spriggs, Douglas, Strain, Janet, Vo, Anthony, Chane, Majed, Hall, Jason, Vijay, Nampalli, Lotun, Kapildeo, Lester, F Martin, Nahhas, Ahed, Pope, Theodore, Nager, Paul, Vohra, Rakesh, Bashir, Riyaz, Ahmed, Hinan, Berlowitz, Michael, Fishberg, Robert, Barrucco, Robert, Yang, Eric, Radin, Michael, Sporn, Daniel, Eisenberg, Steven, Landzberg, Joel, Mcgough, Martin, Turk, Samir, Schwartz, Michael, Sundram, P Sandy, Jain, Diwakar, Zainea, Mark, Bayron, Carlos, Karlsberg, Ronald, Lui, Henry, Keen, William, Westerhausen, Donald, Khurana, Sandeep, Agarwal, Himanshu, Birchem, Jessica, Penny, William, Chang, Mark, Murphy, Sherrill, Schifferdecker, Branislav, Gilbert, John M, Chalavarya, Gopal, Eaton, Charles, Schmedtje, John F, Christenson, Stuart, Denham, Douglas, Macdonell, Alexander, Gibson, Paul, Rahman, Aref, Al Joundi, Tammam, Conrad, Gary, Kotha, Purushotham, Love, Michael, Giesler, Gregory, Rubenstein, Howard, Akright, Laura, Krawczyk, Justine, Wells, Terry, Welker, James, Foster, Robert, Gilmore, Richard, Anderson, Jay, Jacoby, Douglas, Harris, Bill, Gardner, Geraldine, Dandillaya, Ramprasad, Vora, Kishor, Kostis, John, Hunter, John, Laxson, David, Ball, Eric, Camp, Alan, Lopes, Renato, Egydio, Flavia, Kawakami, Anelise, Oliveira, Janaina, Wozniak, Julianna, Matthews, Alexander, Ratky, Caroline, Valiris, Janine, Berdan, Lisa, Hepditch, Anita, Quintero, Kirby, Rorick, Tyrus, Westbrook, Melissa, Pascual, Andrea, Rovito, Carla, Bezault, Madeleine, Drouet, Elodie, Simon, Tabassome, Alsweiler, Caroline, Luyten, Anne, Aylward, Phil, Butters, Julie, Griffith, Liddy, Shaw, Michelle, Grunberg, Lena, Islam, Shahidul, Bregeault, Marie-France, Bougon, Nathalie, Faustino, Douglas, Fontecave, Sylvie, Murphy, Judith, Verrier, Melanie, Agnetti, Veronique, Andersen, Dorthe, Badreddine, Emmy, Bekkouche, Mhamed, Bouancheau, Cecile, Brigui, Imane, Brocklehurst, Maddy, Cianciarulo, Joseph, Devaul, Dawn, Domokos, Szilvia, Gache, Cecile, Gobillot, Caroline, Guillou, Severine, Healy, Jan, Heath, Megan, Jaiwal, Gayatri, Javierre, Carine, Labeirie, Julien, Monier, Myriam, Morales, Ulises, Mrabti, Asmaa, Mthombeni, Bicky, Okan, Betim, Smith, Lucile, Sheller, Jennifer, Sopena, Sebastien, Pellan, Valerie, Benbernou, Fadela, Bengrait, Nafissa, Lamoureux, Maud, Kralova, Katarina, Scemama, Michel, Bejuit, Raphael, Coulange, Anthony, Berthou, Christelle, Repincay, Jerome, Lorenzato, Christelle, Etienne, Alexis, Gouet, Valerie, Loizeau, Virginie, Normand, Mickael, Ourliac, Anne, Rondel, Christelle, Adamo, Antony, Beltran, Pascale, Barraud, Pauline, Dubois-Gache, Helene, Halle, Benjamin, Metwally, Lamia, Mourgues, Maxime, Sotty, Marc, Vincendet, Marion, Cotruta, Raluca, Zhu, Chengyue, Fournie-Lloret, Dominique, Morrello, Christine, Perthuis, Aurelie, Picault, Patrick, Zobouyan, Isabelle, and ODYSSEY OUTCOMES Comm Investigator

Subjects
RISK, Science & Technology, Cardiac & Cardiovascular Systems, CHOLESTEROL, PCSK9 INHIBITION, alirocumab, peripheral artery disease, CARDIOVASCULAR EVENT RATES, acute coronary syndrome, cerebrovascular disease, INSIGHTS, death, Cardiovascular System & Cardiology, MANAGEMENT, ARTERY-DISEASE, Human medicine, OUTPATIENTS, Life Sciences & Biomedicine, major adverse cardiac events
Abstract

BACKGROUND: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin-kexin type 9 inhibition in such patients is undetermined. OBJECTIVES: This pre-specified analysis from ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) determined whether polyvascular disease influenced risks of MACEs and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy. METHODS: Patients were randomized to alirocumab or placebo 1 to 12 months after ACS. The primary MACEs endpoint was the composite of coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. RESULTS: Median follow-up was 2.8 years. Of 18,924 patients, 17,370 had monovascular (coronary) disease, 1,405 had polyvascular disease in 2 beds (coronary and peripheral artery or cerebrovascular), and 149 had polyvascular disease in 3 beds (coronary, peripheral artery, cerebrovascular). With placebo, the incidence of MACEs by respective vascular categories was 10.0%, 22.2%, and 39.7%. With alirocumab, the corresponding absolute risk reduction was 1.4% (95% confidence interval [CI]: 0.6% to 2.3%), 1.9% (95% CI: -2.4% to 6.2%), and 13.0% (95% CI: -2.0% to 28.0%). With placebo, the incidence of death by respective vascular categories was 3.5%, 10.0%, and 21.8%; the absolute risk reduction with alirocumab was 0.4% (95% CI: -0.1% to 1.0%), 1.3% (95% CI: -1.8% to 4.3%), and 16.2% (95% CI: 5.5% to 26.8%). CONCLUSIONS: In patients with recent ACS and dyslipidemia despite intensive statin therapy, polyvascular disease is associated with high risks of MACEs and death. The large absolute reductions in those risks with alirocumab are a potential benefit for these patients. (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab [ODYSSEY OUTCOMES]: NCT01663402). ispartof: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY vol:74 issue:9 pages:1167-1176 ispartof: location:United States status: published

Published
2019

176. Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial

Author

Szarek, Michael, White, Harvey D., Schwartz, Gregory G., Alings, Marco, Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, J. Wouter, Kimura, Takeshi, Kiss, Robert Gabor, Lecorps, Guillaume, Mahaffey, Kenneth W., Moryusef, Angele, Pordy, Robert, Roe, Matthew T., Tricoci, Pierluigi, Xavier, Denis, Zeiher, Andreas M., Steg, Gabriel, Clemmensen, Peter, Gislason, Gunnar, Larsen, John, Davidsen, Flemming, Videbaek, Lars, and Andersen, Dorthe

Subjects
total events, Male, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, food and beverages, alirocumab, Antibodies, Monoclonal/therapeutic use, Middle Aged, Antibodies, Monoclonal, Humanized, acute coronary syndrome, Acute Coronary Syndrome/drug therapy, Humans, Female, Drug Therapy, Combination, Follow-Up Studies, Aged
Abstract

Background: The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths. Objectives: This pre-specified analysis determined the extent to which alirocumab reduced total (first and subsequent) nonfatal cardiovascular events and all-cause deaths in ODYSSEY OUTCOMES. Methods: Hazard functions for total nonfatal cardiovascular events (myocardial infarction, stroke, ischemia-driven coronary revascularization, and hospitalization for unstable angina or heart failure) and death were jointly estimated, linked by a shared frailty accounting for patient risk heterogeneity and correlated within-patient nonfatal events. An association parameter also quantified the strength of the linkage between risk of nonfatal events and death. The model provides accurate relative estimates of nonfatal event risk if nonfatal events are associated with increased risk for death. Results: With 3,064 first and 5,425 total events, 190 fewer first and 385 fewer total nonfatal cardiovascular events or deaths were observed with alirocumab compared with placebo. Alirocumab reduced total nonfatal cardiovascular events (hazard ratio: 0.87; 95% confidence interval: 0.82 to 0.93) and death (hazard ratio: 0.83; 95% confidence interval: 0.71 to 0.97) in the presence of a strong association between nonfatal and fatal event risk. Conclusions: In patients with ACS, the total number of nonfatal cardiovascular events and deaths prevented with alirocumab was twice the number of first events prevented. Consequently, total event reduction is a more comprehensive metric to capture the totality of alirocumab clinical efficacy after ACS.

Published
2019

177. Effects of alirocumab on types of myocardial infarction : insights from the ODYSSEY OUTCOMES trial

Author

White, Harvey D., Steg, Ph. Gabriel, Harrington, Robert A., Endsley, Patricia, Gusi Tragant, Gabriel, Benedicto, Amparo, Gonzalez-Juanatey, Carlos, Camprubi Potau, Mercedes, Plaza Perez, Ignacio, Moris De La Tassa, Cesar, Loma-Osorio Rincon, Pablo, Balaguer Recena, Javier, M Escudier, Juan, Constantine, Godwin, Eppinger, Arleen, Haniffa, Ruvaiz, Tissera, Nirmali, Amarasekera, Stanley, Fernando, Nimali, Jayawardena, Jayanthimala, Santharaj, Wijeyasingam, Ekanayaka, Ruvan, Mendis, Sepalika, Senaratne, Vajira, Mayurathan, Gnanamoorthy, Hess, Connie Ng, Sirisena, Thilak, Rajapaksha, Ajantha, Herath, Jagath I., Amarasena, Naomali, Berglund, Stefan, Rasmanis, Gundars, Hagstrom, Emil, Witt, Nils, Mourtzinis, Georgios, Nicol, Peter, Hlatky, Mark A., Hansen, Ole, Romeo, Stefano, Jensen, Steen Agergaard, Torstensson, Ingemar, Ahremark, Ulf, Sundelin, Torbjorn, Moccetti, Tiziano, Mueller, Christian, Mach, Francois, Jordan, Joseph Dedrick, Binder, Ronald, Chiang, Chern-En, Tsai, Wei-Chuan, Ueng, Kwo-Chang, Lai, Wen-Ter, Liu, Ming-En, Hwang, Juey-Jen, Yin, Wei-Hsian, Hsieh, I. Chang, Lin, Wei Hsiang, Knowles, Joshua W., Kuo, Jen-Yuan, Huang, Tsuei-Yuan, Fang, Chih-Yuan, Kaewsuwanna, Pinij, Soonfuang, Wasant, Jintapakorn, Woravut, Sukonthasarn, Apichard, Sritara, Piyamitr, Wongpraparut, Nattawut, Sastravaha, Krisada, Kolls, Bradley J., Sansanayudh, Nakarin, Kehasukcharoen, Wirash, Piyayotai, Dilok, Camsari, Ahmet, Kultursay, Hakan, Guneri, Sema, Mutlu, Bulent, Ersanli, Murat, Demirtas, Mustafa, Kirma, Cevat, Kong, David F., Ural, Ertan, Koldas, Lale, Karpenko, Oleksandr, Prokhorov, Alexander, Vakaluyk, Ihor, Myshanych, Halyna, Reshotko, Dmytro, Batushkin, Valeriy, Rudenko, Leonid, Kovalskyi, Ihor, Leonardi, Sergio, Kushnir, Mykola, Tseluyko, Vira, Mostovoy, Yuriy, Stanislavchuk, Mykola, Kyiak, Yulian, Karpenko, Yuriy, Malynovsky, Yaroslav, Klantsa, Andriy, Kutniy, Oles, Amosova, Ekaterina, Lillis, Linda, Tashchuk, Viktor, Leshchuk, Oleh, Parkhomenko, Alexander, Rishko, Mykola, Kopytsya, Mykola, Yagensky, Andriy, Vatutin, Mykola, Bagriy, Andriy, Barna, Olga M., Ushakov, Olexiy, Jukema, J. Wouter, Lopes, Renato D., Dzyak, Georgiy, Goloborodko, Borys, Rudenko, Anatolii, Trevelyan, Jasper, Zaman, Azfar, Lee, Kaeng, Moriarty, Andrew, Aggarwal, Rajesh K., Clifford, Piers, Wong, Yuk-Ki, Maron, David J., Iqbal, Syed M. R., Subkovas, Eduardas, Braganza, Denise, Sarkar, David, Storey, Robert, Griffiths, Huw, Mcclure, Sam, Muthusamy, Rangasamy, Kurian, John, Levy, Terry, Marcus, Jill, Barr, Craig, Kadr, Honer, Gerber, Robert, Simaitis, Audrius, Soran, Handrean, Mathur, Anthony, Brodison, Adrian, Oliver, Richard, Mudawi, Telal, Reynolds, Timothy, Mathews, Robin, Sharman, David, Butler, Rob, Wilkinson, Peter, Lip, Gregory Y. H., Halcox, Julian, Vardi, Gil, Baldari, Duccio, Brabham, David, Treasure, Charles, Dahl, Charles, Mehta, Rajendra H., Palmer, Bruce, Wiseman, Alan, Khan, Abul, Puri, Sanjeev, Mohart, Ann Elizabeth, Ince, Carlos, Flores, Enrique, Wright, Scott, Cheng, Shi-Chi, Rosenberg, Michael, Mentz, Robert J., Rogers, William Jr., Kosinski, Edward, Forgosh, Les, Waltman, Jonathan, Khan, Misal, Shoukfeh, Mohammad, Dagher, Georges, Lieber, Ira, Kumar, Priya, East, Cara, Moreira, Humberto Graner, Krichmar, Perry, White, Lindsey, Knickelbine, Thomas, Haldis, Thomas, Gillespie, Eve, Suh, David, Arif, Imran, Akhter, Faiq, Carlson, Eric, D'Urso, Michael, Patel, Chetan B., El-Ahdab, Fadi, Nelson, William, Harris, Barry, Cohen, Steven, Carter, Luther, Sabatino, Kenneth, Haddad, Tariq, Malik, Amir, Rao, Sunder, Mulkay, Angel, Pereira, Sabrina Bernardez, Jovin, Ion, Klancke, Kim, Malhotra, Vinay, Devarapalli, Sai K., Koren, Michael, Chandna, Harish, Dodds, George, Janik, Matthew, Moran, Joseph, Sumner, Andrew, Perkins, Lynn, Kobayashi, John, Davis, William, Yazdani, Shahram, Pasquini, John, Thakkar, Maitreya, Vedere, Amarnath, Leimbach, Wayne, Rider, James, Singh, Narendra, Shah, Anil V., Povsic, Thomas J., Moriarty, Patrick M., Janosik, Denise, Pepine, Carl, Berman, Brett, Gelormini, Joseph, Daniels, Christopher, Keating, Friederike, Kondo, Nicholas I., Shetty, Sanjay, Waider, Winfried, Puymirat, Etienne, Takata, Theodore, Abu-Fadel, Mazen, Shah, Vipul, Aggarwal, Rahul, Izzo, Mark, Kumar, Anil, Hattler, Brack, Link, Chad, Bortnick, Anna, Kinzfogl, George, Jones, William Schuyler, Ghitis, Arnold, Larry, John, Teufel, Edward, Kuhlman, Peter, Mclaurin, Brent, Zhang, Wenwu, Thew, Stephen, Abbas, Jalal, White, Matthew, Ranadive, Nandkishore, Shah, Bimal R., Gring, Christian, Henderson, David, Schuchard, Timothy, Farhat, Naim, Kline, Geoffrey, Mahal, Sharan, Whitaker, Jack, Speirs, Shawn, Andersen, Rolf, Daboul, Nizar, Sherwood, Matthew W., Horwitz, Phillip, Jafar, Zubair, Mcgarvey, Joseph Jr., Panchal, Vipul, Voyce, Stephen, Blok, Thomas, Sheldon, William, Azizad, Masoud M., Schmalfuss, Carsten, Picone, Mark, Stringfellow, Kenya, Herzog, William Jr., Lindsey, Jason, Nowins, Rosemary, Lepor, Norman, El Shahawy, Mahfouz, Weintraub, Howard, Irimpen, Anand, May, Wade, Galski, Thomas, Chu, Alan, Sujjavanich, Darin, Mody, Freny, Hodes, Zachary, Fairlamb, James, Lambert, Charles Jr., Raisinghani, Ajit, Abbate, Antonio, King, Marilyn, Carey, Charles, Gerber, Jaime, Younis, Liwa, Toma, Mustafa, Park, Hyeun (Tom, Vidovich, Mladen, Knutson, Thomas, Friedman, Dennis, Chaleff, Fred, Loussararian, Arthur, Kimmelstiel, Carey, Silver, Kevin, Foster, Malcolm, Tonnessen, Glen, Trotter, Charlene, Amlani, Mohamadali, Wali, Andreas, Malozzi, Christopher, Wattanakit, Keattiyoat, O'Donnell, Philip J., Singal, Dinesh, Jaffrani, Naseem, Banuru, Sridhar, Fisher, Daniel, Xenakis, Mark, van Diepen, Sean F. P., Perlmutter, Neal, Bhagwat, Ravi, Strader, James Jr., Akyea-Djamson, Ayim, Labroo, Ajay, Lee, Kwan, Marais, H. John, Claxton, Edmund Jr., Berk, Martin, Rossi, Peter, Mahaffey, Kenneth W., Wilson, Matthew D., Joshi, Parag, Khaira, Ajit S., Kumkumian, Greg, Lupovitch, Steven, Purow, Joshua, Welka, Stephen, Hoffman, David, Fischer, Stuart, Soroka, Eugene, Eagerton, Donald, Yan, Andrew Tze-Kay, Pancholy, Samir, Ray, Michael, Farrar, Michael, Pollock, Stewart, French, William J., Diamantis, Steve, Gimple, Lawrence, Schwartz, Steven, Pereira, Edward, Spriggs, Douglas, Schiavi, Lilia B., Strain, Janet, Vo, Anthony, Chane, Majed, Hall, Jason, Vijay, Nampalli, Lotun, Kapildeo, Lester, F. Martin, Nahhas, Ahed, Pope, Theodore, Nager, Paul, Garrido, Marcelo, Vohra, Rakesh, Bashir, Riyaz, Ahmed, Hinan, Berlowitz, Michael, Fishberg, Robert, Barrucco, Robert, Yang, Eric, Radin, Michael, Sporn, Daniel, Eisenberg, Steven, Alvarisqueta, Andres F., Landzberg, Joel, Mcgough, Martin, Turk, Samir, Schwartz, Michael, Sundram, P. Sandy, Jain, Diwakar, Zainea, Mark, Bayron, Carlos, Karlsberg, Ronald, Lui, Henry, Sassone, Sonia A., Keen, William, Westerhausen, Donald Jr., Khurana, Sandeep, Agarwal, Himanshu, Birchem, Jessica, Penny, William Jr., Chang, Mark, Gilbert, John M., Chalavarya, Gopal, Eaton, Charles, Bordonava, Anselmo P., Schmedtje, John F. Jr., Christenson, Stuart, Denham, Douglas, Macdonell, Alexander, Gibson, Paul, Rahman, Aref, Al Joundi, Tammam, Conrad, Gary, Kotha, Purushotham, Love, Michael, Alves De Lima, Alberto E., Giesler, Gregory, Rubenstein, Howard, Akright, Laura, Schifferdecker, Branislav, Krawczyk, Justine, Wells, Terry, Welker, James, Foster, Robert, Gilmore, Richard, Anderson, Jay, Schmidberg, Jorge M., Jacoby, Douglas, Harris, Bill, Gardner, Geraldine, Dandillaya, Ramprasad, Vora, Kishor, Kostis, John, Hunter, John, Laxson, David, Ball, Eric, Duronto, Ernesto A., Moryusef, Angele, Caruso, Orlando C., Novaretto, Leonardo P., Angel Hominal, Miguel, Montana, Oscar R., Caccavo, Alberto, Gomez Vilamajo, Oscar A., Lorenzatti, Alberto J., Cartasegna, Luis R., Paterlini, Gustavo A., Mackinnon, Ignacio J., Pordy, Robert, Caime, Guillermo D., Amuchastegui, Marcos, Codutti, Oscar R., Jure, Horacio O., Bono, Julio O. E., Hrabar, Adrian D., Vallejos, Julio A., Ahuad Guerrero, Rodolfo A., Novoa, Federico, Patocchi, Cristian A., Roe, Matthew T., Zaidman, Cesar J., Giuliano, Maria E., Dran, Ricardo D., Vico, Marisa L., Carnero, Gabriela S., Guzman, Pablo N., Medrano Allende, Juan C., Garcia Brasca, Daniela F., Bustamante Labarta, Miguel H., Nani, Sebastian, Blumberg, Eduardo D. S., Colombo, Hugo R., Liberman, Alberto, Luciardi, Hector L., Waisman, Gabriel D., Berli, Mario A., Garcia Duran, Ruben O., Cestari, Horacio G., Luquez, Hugo A., Giordano, Jorge A., Tricoci, Pierluigi, Saavedra, Silvia S., Waites, Jonathon H., Collins, Nicholas, Soward, Allan, Hii, Chris L. S., Shaw, James, Arstall, Margaret A., Horowitz, John, Rogers, James F., Colquhoun, David, Zeiher, Andreas M., Flores, Romulo E. Oqueli, Roberts-Thomson, Philip, Raffel, Owen, Lehman, Sam J., Coverdale, Steven G. M., Garrahy, Paul J., Starmer, Gregory, Sader, Mark, Carroll, Patrick A., Zweiker, Robert, Szarek, Michael, Schwartz, Gregory G., Hoppe, Uta, Huber, Kurt, Berger, Rudolf, Weidinger, Franz, Faes, Dirk, Hermans, Kurt, Pirenne, Bruno, Leone, Attilio, Hoffer, Etienne, Vrolix, Mathias C. M., Aylward, Philip E., De Wolf, Luc, Wollaert, Bart, Castadot, Marc, Dujardin, Karl, Beauloye, Christophe, Vervoort, Geert, Striekwold, Harry, Convens, Carl, Roosen, John, Barbato, Emanuele, Drexel, Heinz, Claeys, Marc, Cools, Frank, Terzic, Ibrahim, Barakovic, Fahir, Midzic, Zlatko, Pojskic, Belma, Fazlibegovic, Emir, Durak-Nalbantic, Azra, Vulic, Dusko, Muslibegovic, Adis, Sinnaeve, Peter, Reis, Gilmar, Sousa, Luciano, Nicolau, Jose C., Giorgeto, Flavio E., Silva, Ricardo P., Maia, Lilia Nigro, Rech, Rafael, Rossi, Paulo R. F., Cerqueira, Maria Jose A. G., Duda, Norberto, Dilic, Mirza, Kalil, Renato, Kormann, Adrian, Abrantes, Jose Antonio M., Pimentel Filho, Pedro, Soggia, Ana Priscila, de Santos, Mayler O. N., Neuenschwander, Fernando, Bodanese, Luiz C., Michalaros, Yorghos L., Eliaschewitz, Freddy G., Vidotti, Maria H., Leaes, Paulo E., Botelho, Roberto V., Kaiser, Sergio, Fernandes Manenti, Euler Roberto F., Precoma, Dalton B., Moura Jorge, Jose C., Silva, Pedro G. M. de B., Silveira, Jose A., Saporito, Wladimir, Gotcheva, Nina N., Marin Neto, Jose A., Feitosa, Gilson S., Ritt, Luiz Eduardo F., de Souza, Juliana A., Costa, Fernando, Souza, Weimar K. S. B., Reis, Helder J. L., Machado, Leandro, Aidar Ayoub, Jose Carlos, Goodman, Shaun G., Todorov, Georgi V., Nikolov, Fedya P., Velcheva, Elena S., Tzekova, Maria L., Benov, Haralambi O., Petranov, Stanislav L., Tumbev, Haralin S., Shehova-Yankova, Nina S., Markov, Dimitar T., Raev, Dimitar H., Prieto, Juan-Carlos, Mollov, Mihail N., Kichukov, Kostadin N., Ilieva-Pandeva, Katya A., Ivanova, Raya, Mincheva, Valentina M., Lazov, Petar V., Dimov, Bojidar I., Senaratne, Manohara, Stone, James, Yong, Huo, Kornder, Jan, Pearce, Stephen, Dion, Danielle, Savard, Daniel, Pesant, Yves, Pandey, Amritanshu, Robinson, Simon, Gosselin, Gilbert, Vizel, Saul, Hoag, Gordon, Bhatt, Deepak L., Lopez-Jaramillo, Patricio, Bourgeois, Ronald, Morisset, Anne, Sabbah, Eric, Sussex, Bruce, Kouz, Simon, MacDonald, Paul, Diaz, Ariel, Michaud, Nicolas, Fell, David, Leung, Raymond, Pecin, Ivan, Vuurmans, Tycho, Lai, Christopher, Nigro, Frank, Davies, Richard, Nogareda, Gustavo, Vijayaraghavan, Ram, Ducas, John, Lepage, Serge, Mehta, Shamir, Cha, James, Reiner, Zeljko, Dupuis, Robert, Fong, Peter, Rodes-Cabau, Josep, Fadlallah, Hussein, Cleveland, David, Huynh, Thao, Bata, Iqbal, Hameed, Adnan, Pincetti, Cristian, Potthoff, Sergio, Ostadal, Petr, Acevedo, Monica, Aguirre, Arnoldo, Vejar, Margarita, Yanez, Mario, Araneda, Guillermo, Fernandez, Mauricio, Perez, Luis, Varleta, Paola, Florenzano, Fernando, Huidobro, Laura, Poulsen, Steen Hvitfeldt, Raffo, Carlos A., Olivares, Claudia, Chen, Jiyan, Dong, Yugang, Huang, Weijian, Wang, Jianzhong, Huang, Shi'An, Yao, Zhuhua, Cui, Lan, Lin, Wenhua, Viigimaa, Margus, Sun, Yuemin, Wang, Jingfeng, Li, Jianping, Zhang, Xuelian, Zhu, Hong, Chen, Dandan, Huang, Lan, Dong, Shaohong, Su, Guohai, Xu, Biao, Nieminen, Markku S., Su, Xi, Cheng, Xiaoshu, Lin, Jinxiu, Zong, Wenxia, Li, Huanming, Feng, Yi, Xu, Dingli, Yang, Xinchun, Ke, Yuannan, Lin, Xuefeng, Danchin, Nicolas, Zhang, Zheng, Zheng, Zeqi, Luo, Zhurong, Chen, Yundai, Ding, Chunhua, Zheng, Yang, Li, Xiaodong, Peng, Daoquan, Li, Ying, Wei, Meng, Chumburidze, Vakhtang, Liu, Shaowen, Yu, Yihua, Qu, Baiming, Jiang, Weihong, Zhou, Yujie, Zhao, Xingsheng, Yuan, Zuyi, Guo, Ying, Xu, Xiping, Shi, Xubo, Marx, Nikolaus, Ge, Junbo, Fu, Guosheng, Bai, Feng, Fang, Weiyi, Shou, Xiling, Yang, Xiangjun, Wang, Jian'An, Jaramillo, Nicolas, Vallejo, Gregorio Sanchez, Botia, Diana C. Luna, Bittner, Vera A., Liberopoulos, Evangelos, Lopez, Rodrigo Botero, De Salazar, Dora I. Molina, Bonfanti, Alberto J. Cadena, Higuera, Juan Diego, Silva, Sandra I. Barrera, Lozada, Henry J. Garcia, Arroyo, Julian A. Coronel, Mendoza, Jose L. Accini, Ruiz, Ricardo L. Fernandez, Fernandez, Angela M., Montenegro Valdovinos, Pablo Carlos, Jatin, Fernando G. Manzur, Herazo, Aristides Sotomayor, Parada, Jeffrey Castellanos, Triana, Miguel A. Urina, Spinar, Jindrich, Horak, David, Stasek, Josef, Alan, David, Machova, Vilma, Linhart, Ales, Tse, Hung-Fat, Novotny, Vojtech, Kaucak, Vladimir, Rokyta, Richard, Naplava, Robert, Coufal, Zdenek, Adamkova, Vera, Podpera, Ivo, Zizka, Jiri, Motovska, Zuzana, Marusincova, Ivana, Kiss, Robert Gabor, Svab, Premysl, Heinc, Petr, Kuchar, Jiri, Povolny, Petr, Raungaard, Bent, Clemmensen, Peter, Bang, Lia E., May, Ole, Bottcher, Morten, Hove, Jens D., Xavier, Denis, Frost, Lars, Gislason, Gunnar, Larsen, John, Johansen, Peter Betton, Hald, Flemming, Jeppesen, Jorgen, Nielsen, Tonny, Kristensen, Kjeld S., Walichiewicz, Piotr Maria, Lomholdt, Jens D., Zahger, Doron, Klausen, Ib C., Nielsen, Peter Kaiser, Davidsen, Flemming, Videbaek, Lars, Soots, Mai, Vahula, Veiko, Hedman, Anu, Soopold, Sllar, Martsin, Kaja, Taskinen, Marja-Riitta, Valgimigli, Marco, Porthan, Kimmo, Airaksinen, Juhani K., Juonala, Markus, Kiviniemi, Tuomas, Vikman, Saila, Posio, Pirjo, Taurio, Jyrki, Huikuri, Heikki, Kaikkonen, Kari, Coste, Pierre, Kimura, Takeshi, Ferrari, Emile, Morel, Olivier, Montalescot, Gilles, Barone-Rochette, Gilles, Mansourati, Jacques, Cottin, Yves, Steg, Philippe Gabriel, Leclercq, Florence, Belhassane, Abdelkader, Delarche, Nicolas, Kim, Hyo Soo, Boccara, Franck, Paganelli, Franck, Clerc, Jerome, Schiele, Francois, Aboyans, Victor, Probst, Vincent, Berland, Jacques, Lefevre, Thierry, Khintibidze, Irakli, Shaburishvili, Tamaz, Kim, Sang-Hyun, Pagava, Zurab, Ghlonti, Ramaz, Lominadze, Zaza, Khabeishvili, George, Hemetsberger, Rayyan, Rauch-Kroehnert, Ursula, Stratmann, Matthias, Appel, Karl-Friedrich, Schmidt, Ekkehard, Omran, Heyder, Diaz, Rafael, Erglis, Andrejs, Stellbrink, Christoph, Dorsel, Thomas, Lianopoulos, Emmanouil, Marx, Roger, Zirlik, Andreas, Schellenberg, Detlev, Heitzer, Thomas, Laufs, Ulrich, Gielen, Stephan, Laucevicius, Aleksandras, Winkelmann, Bernhard, Behrens, Steffen, Sydow, Karsten, Simonis, Gregor, Muenzel, Thomas, Werner, Nikos, Leggewie, Stefan, Boecker, Dirk, Braun-Dullaeus, Ruediger, Toursarkissian, Nicole, Kedev, Sasko, Jeserich, Michael, Weissbrodt, Matthias, Schaeufele, Tim, Weil, Joachim, Voeller, Heinz, Waltenberger, Johannes, Natour, Mohammed, Steiner, Stephan, Heidenreich, Lothar, Gremmler, Uwe, Yusoff, Khalid, Killat, Holger, Patsilinakos, Sotiris, Kartalis, Athanasios, Manolis, Athanassios, Sionis, Dimitrios, Skoumas, Ioannis, Athyros, Vasilios, Parthenakis, P. I. Frangkiskos, Hahalis, P. I. Georgios, Ramos Lopez, Gabriel Arturo, Lekakis, John, Xatzitolios, Apostolos, Fausto Ovando, Sergio R., Arango Benecke, Juan L., Rodriguez De Leon, Edgar R., Yan, Bryan P. Y., Siu, David C. W., Turi, Tibor, Merkely, Bela, Alings, Marco, Ungi, Imre, Lupkovics, Geza, Nagy, Lajos, Katona, Andras, Edes, Istvan, Muller, Gabor, Horvath, Ivan, Kapin, Tibor, Falukozy, Jozsef, Halvorsen, Sigrun, Kumbla, Mukund, Sandhu, Manjinder, Annam, Sharath, Proddutur, Naveen Reddy, Premchand, Rajendra K., Mahajan, Ajaykumar, Abhyanakar, Atul D., Kerkar, Prafulla, Govinda, Ravishankar A., Oomman, Abraham, Correa Flores, Roger M., Sinha, Dhurjati, Patil, Sachin N., Kahali, Dhiman, Sawhney, Jitendra, Joshi, Abhijeet B., Chaudhary, Sanjeev, Harkut, Pankaj, Guha, Santanu, Porwal, Sanjay, Jujjuru, Srimannarayana, Sy, Rody G., Pothineni, Ramesh B., Monteiro, Minguel R., Khan, Aziz, Iyengar, Shamanna S., Grewal, Jasprakash Singh, Chopda, Manoj, Fulwani, Mahesh C., Patange, Aparna, Chopra, Vijay K., Goyal, Naresh K., Budaj, Andrzej, Shinde, Rituparna, Manakshe, Gajendra V., Patki, Nitin, Sethi, Sumeet, Munusamy, Vengatesh, Karna, Sunil, Adhyapak, Srilakshmi, Pandurangi, Ulhas, Mathur, Rishabh, Kalashetti, Suhas, Edelberg, Jay M., Morais, Joao, Bhagwat, Ajit, Raghuraman, Bagirath, Yerra, Shiv Kumar, Bhansali, Prasant, Borse, Rohidas, Das, Srihari, Abdullakutty, Jabir, Saathe, Shireesh, Palimkar, Priya, Atar, Shaul, Dorobantu, Maria, Shechter, Michael, Mosseri, Morris, Arbel, Yaron, Lotan, Chaim, Rosenschein, Uri, Katz, Amos, Henkin, Yaakov, Francis, Adi, Klutstein, Marc, Nikolsky, Eugenia, Karpov, Yuri, Turgeman, Yoav, Halabi, Majdi, Kornowski, Ran, Jonas, Michael, Amir, Offer, Rozenman, Yoseph, Fuchs, Shmuel, Hussein, Osamah, Gavish, Dov, Vered, Zvi, Ristic, Arsen D., Caraco, Yoseph, Elias, Mazen, Tov, Naveh, Piovaccari, Giancarlo, De Pellegrin, Annamaria, Guardigli, Gabriele, Licciardello, Giovanni, Auguadro, Carla, Cuccia, Claudio, Salvioni, Alessandro, Chua, Terrance, Musumeci, Giuseppe, Calabro, Paolo, Novo, Salvatore, Faggiano, Pompilio, De Cesare, Nicoletta B., Berti, Sergio, Cavallini, Claudio, Puccioni, Enrico, Galvani, Marcello, Tespili, Maurizio, Murin, Jan, Piatti, Piermarco, Palvarini, Michela, De Luca, Giuseppe, Violini, Roberto, De Leo, Alessandro, Filardi, Pasquale Perrone, Ferratini, Maurizio, Dai, Kazuoki, Kamiya, Haruo, Ando, Kenji, Fras, Zlatko, Takeda, Yoshihiro, Morino, Yoshihiro, Hata, Yoshiki, Kimura, Kazuo, Kishi, Koichi, Michishita, Ichiro, Uehara, Hiroki, Higashikata, Toshinori, Hirayama, Atsushi, Hirooka, Keiji, Dalby, Anthony J., Sakagami, Satoru, Taguchi, Shuichi, Koike, Akihiro, Fujinaga, Hiroyuki, Koba, Shinji, Kozuma, Ken, Kawasaki, Tomohiro, Ono, Yujiro, Shimizu, Masatoshi, Katsuda, Yousuke, Tunon, Jose, Wada, Atsuyuki, Shinke, Toshiro, Ako, Junya, Fujii, Kenshi, Takahashi, Toshiyuki, Sakamoto, Tomohiro, Furukawa, Yutaka, Sugino, Hiroshi, Mano, Toshiaki, Utsu, Noriaki, de Silva, H. Asita, Ito, Kashima, Haraguchi, Takuya, Ueda, Yasunori, Nishibe, Akira, Fujimoto, Kazuteru, Yoon, Jung Han, Park, Hun Sik, Chae, In-Ho, Kim, Moo Hyun, Jeong, Myung Ho, Rha, Seungwoon, Kim, Chongjin, Hong, Taekjong, Busmane, Arija, Pontaga, Natalija, Strelnieks, Aldis, Mintale, Iveta, Sime, Iveta, Petrulioniene, Zaneta, Kavaliauskiene, Roma, Muller, Christian, Jurgaitiene, Ruta, Sakalyte, Gintare, Slapikas, Rimvydas, Norkiene, Sigute, Misonis, Nerijus, Kibarskis, Aleksandras, Kubilius, Raimondas, Bojovski, Stojko, Lozance, Nensi, Kjovkaroski, Aleksandar, Doncovska, Snezana, Ong, Tiong Kiam, Kasim, Sazzli, Maskon, Oteh, Kandasamy, Balachandran, Liew, Houng B., Mohamed, Wan Mohd Izani Wan, Garcia Castillo, Armando, Carrillo Calvillo, Jorge, Fajardo Campos, Pedro, Nunez Fragoso, Juan Carlos, Bayram Llamas, Edmundo Alfredo, Alcocer Gamba, Marco Antonio, Carranza Madrigal, Jaime, Gonzalez Salas, Luis Gerardo, Lopez Rosas, Enrique, Gonzalez Diaz, Belinda, Salcido Vazquez, Eduardo, Nacoud Ackar, Alfredo, Llamas Esperon, Guillermo Antonio, Martinez Sanchez, Carlos Rodolfo, Guerrero De Leon, Maria, Suarez Otero, Rodrigo, Fanghanel Salmon, Guillermo, Perez Rios, Jesus Antonio, Garza Ruiz, Jose Angel, Breedveld, Robert W., Hoogslag, Pieter A. M., Suryapranata, Harry, Oomen, Antonius, Wiersma, Jacobijne J., Van Der Wal, Ruud M. A., Van Huysduynen-Monraats, Pascalle S. Hooft, Karalis, Ioannis, Verdel, Gerardus J. E., Brueren, Bart R. G., Troquay, Roland P. Th, Viergever, Eric P., Al-Windy, Nadea Y. Y., Bartels, Gerard L., Ray, Kausik K., Cornel, Jan H., Hermans, Walter R. M., Herrman, Johannes P. R., Bos, Robert J., Groutars, Reginald G. E. J., Van Der Zwaan, Coenraad C., Kaplan, Refik, Ronner, Eelko, Groenemeijer, Bjorn E., Bronzwaer, Patrick N. A., Liem, Anho A. H., Rensing, Bernard J. W. M., Bokern, Marcel J. J. A., Nijmeijer, Remco, Hersbach, Ferry M. R. J., Willems, Frank F., Gosselink, Antonius T. M., Elliott, John, Wilkins, Gerard, Fisher, Raewyn, Vogel, Robert, Scott, Douglas, Hart, Hamish, Stewart, Ralph, Harding, Scott, Ternouth, Ian, Fisher, Nicholas, Aitken, Denise, Anscombe, Russell, Tomala, Tadeusz, Nygard, Ottar, Chaitman, Bernard, Sparby, Jon Arne, Andersen, Kjell, Gullestad, Lars, Jortveit, Jarle, Munk, Peter S., Hurtig, Ulf, Ticona, Jorge R. Calderon, Velasquez, Julio R. Durand, Miguel, Sandra A. Negron, Perez, Enrique S. Sanabria, Kelsey, Sheryl F., Chambilla, Jesus M. Carrion, Ayala, Carlos A. Chavez, Leon, Reynaldo P. Castillo, Gonzales, Rolando J. Vargas, Zuniga, Jose D. Hernandez, Cosavalente, Luis A. Camacho, Mannucci, Jorge E. Bravo, Navarro, Nassip C. Llerena, Concha, Yudy M. Roldan, Chavez, Victor E. Rodriguez, Olsson, Anders G., Hernandez, Henry A. Anchante, Nunez, Carlos A. Zea, Ferrolino, Arthur, Sy, Rosa Allyn G., Tirador, Louie, Matiga, Generoso, Coching, Raul Martin, Bernan, Alisa, Rogelio, Gregorio, Morales, Dante D., Rouleau, Jean-Lucien, Tan, Edgar, Wlodarczak, Adrian, Jaworska, Krystyna, Skonieczny, Grzegorz, Pawlowicz, Lidia, Wojewoda, Pawel, Busz-Papiez, Benita, Bednarski, Janusz, Goch, Aleksander, Staneta, Pawel, Simoons, Maarten L., Dulak, Elzbieta, Saminski, Krzysztof, Krasowski, Wlodzimierz, Sudnik, Wanda, Zurakowski, Aleksander, Skorski, Marcin, Lysek, Roman, Miklaszewicz, Beata, Kubica, Jacek, Lipko, Jan Andrzej, Alexander, Karen, Kostarska-Srokosz, Edyta, Piepiorka, Marek, Drzewiecka, Anna, Sciborski, Ryszard, Stasiewski, Arkadiusz, Blicharski, Tomasz, Bystryk, Leszek, Szpajer, Michal, Korol, Marek, Czerski, Tomasz, Meloni, Chiara, Mirek-Bryniarska, Ewa, Gniot, Jacek, Lubinski, Andrzej, Gorny, Jerzy, Franek, Edward, Monteiro, Pedro, Bastos, Jose Mesquita, Pereira, Helder H., Martins, Dinis, Seixo, Filipe, Rosenson, Robert, Mendonca, Carlos, Botelho, Ana, Minescu, Bogdan, Istratoaie, Octavian, Tesloianu, Dan N., Cristian, Gabriel, Podoleanu, Cristian G. C., Constantinescu, Mircea C. A., Bengus, Cristina M., Militaru, Constantin, Sijbrands, Eric J. G., Rosu, Doina, Parepa, Irinel R., Matei, Adrian V., Alexandru, Tom M., Shvarts, Yury, Orlikova, Olga, Kobalava, Zhanna, Barbarash, Olga L., Markov, Valentin, Lyamina, Nadezhda, Alexander, John H., Gordienko, Alexander, Zrazhevsky, Konstantin, Vishnevsky, Alexander Y., Gurevich, Victor, Stryuk, Raisa, Lomakin, Nikita V., Bokarev, Igor, Shalaev, Sergey, Khaisheva, Larisa, Chizhov, Petr, Armaganijan, Luciana, Viktorova, Inna, Osokina, Natalya, Akatova, Evgenia, Chumakova, Galina, Libov, Igor, Voevoda, Mikhail I., Tretyakova, Tatyana V., Baranov, Evgeny, Shustov, Sergey, Yakushin, Sergey, Hanotin, Corinne, Bagai, Akshay, Gordeev, Ivan, Khasanov, Niiaz, Reshetko, Olga, Sotnikova, Tatiana, Molchanova, Olga, Nikolaev, Konstantin, Gapon, Liudmila, Baranova, Elena, Shogenov, Zaur, Kosmachova, Elena, Bahit, Maria Cecilia, Karpov, Yuriy, Povzun, Anton, Egorova, Liudmila, Tyrenko, Vadim V., Ivanov, Igor G., Simic, Dragan, Ivanovic, Nikola, Davidovic, Goran, Tasic, Nebojsa, Asanin, Milika R., Brennan, J. Matthew, Stojic, Stevo, Apostolovic, Svetlana R., Ilic, Stevan, Putnikovic, Biljana, Stankovic, Aleksandar, Arandjelovic, Aleksandra, Radovanovic, Slavica, Balinovac, Jovan, Dincic, Dragan V., Seferovic, Petar, Clifton, Shaun, Dodic, Slobodan, Dimkovic, Sinisa, Poh, Kian-Keong, Ong, Hean Yee, Micko, Karol, Nociar, Jan, Pella, Daniel, Fulop, Peter, Hranai, Marian, Palka, Juraj, DeVore, Adam D., Mazur, Juraj, Majercak, Ivan, Dzupina, Andrej, Fazekas, Frantisek, Gonsorcik, Jozef, Bugan, Viliam, Selecky, Juraj, Kamensky, Gabriel, Strbova, Jaroslava, Smik, Rudolf, Deloatch, Shalonda, Dukat, Andrej, Zuran, Ivan, Oklukar, Janez, Suligoj, Natasa Cernic, Cevc, Matija, Lipar, Luka, Cyster, Henry P., Ranjith, Naresh, Corbett, Clive, Bayat, Junaid, Dickey, Sheila, Makotoko, Ellen Makoali, Kapp, Ilse E., Basson, Matthys M. de V., Lottering, Hanlie, Van Zyl, Louis J., Sebastian, Peter J., Pillay, Thayabran, Saaiman, Jan A., Commerford, Patrick J., Cassimjee, Soraya, Dombrowski, Keith, Ebrahim, Iftikhar O., Sarvan, Mahomed, Mynhardt, Joseph H., Reuter, Helmuth, Moodley, Rajendran, Vida, Manuel, Cequier Fillat, Angel R., Bodi Peris, Vicente, Fuentes Jimenez, Francisco, Ducrocq, Gregory, Marin, Francisco, Cruz Fernandez, Jose M., Gil-Extremera, Blas, Worner Diz, Fernando, Garcia-Dorado, David, Iniguez, Andres, Tunon Fernandez, Jose, Gonzalez-Juanatey, Jose R., Fernandez Portales, Javier, Civeira Murillo, Fernando, Eapen, Zubin, Matas Pericas, Laia, Luis Zamorano, Jose, De Mora Martin, Manuel, Bruguera Cortada, Jordi, Alonso Martin, Joaquin J., De Berrazueta Fernandez, Jose R., Diaz Fernandez, Jose Francisco, Garcia Lledo, Jose Alberto, Cosin Sales, Juan, Botas Rodriguez, Javier, Sinnaeve, Peter, İÜC, Ege Üniversitesi, Cardiology, Internal Medicine, and ODYSSEY OUTCOMES Investigators

Subjects
Male, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Cardiac & Cardiovascular Systems, Myocardial Infarction, UNIVERSAL DEFINITION, 030204 cardiovascular system & hematology, THERAPY, DISEASE, chemistry.chemical_compound, 0302 clinical medicine, Cardiac and Cardiovascular Systems, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, 1102 Cardiorespiratory Medicine and Haematology, Oxygen supply, Kardiologi, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, CHOLESTEROL, Middle Aged, MI types, Cardiology, LDL Cholesterol Lipoproteins, Female, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, ODYSSEY OUTCOMES Investigators, Antibodies, Monoclonal, Humanized, CLASSIFICATION, 03 medical and health sciences, Double-Blind Method, Internal medicine, medicine, Humans, ddc:610, Alirocumab, Mortality, Prevention, METAANALYSIS, Aged, Science & Technology, Task force, Cholesterol, business.industry, EVOLOCUMAB, 1103 Clinical Sciences, Cholesterol, LDL, medicine.disease, Evolocumab, chemistry, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, Human medicine, business
Abstract

Gislason, Gunnar H/0000-0002-0548-402X; Malynovsky, Yaroslav V/0000-0002-9118-1104; Bhatt, Deepak L./0000-0002-1278-6245; Nikolaev, Konstantin/0000-0003-4601-6203; Sherwood, Matthew/0000-0002-4305-5883; Chumakova, Galina A/0000-0002-2810-6531; Raffel, Owen C/0000-0001-5470-7050; Leonardi, Sergio/0000-0002-4800-6132; Tse, Hung Fat/0000-0002-9578-7808; Reshetko, Olga/0000-0003-3107-7636; Pereira, Helder/0000-0001-8656-4883; Racca, Vittorio/0000-0002-4465-3789; Podoleanu, Cristian/0000-0001-9987-2519; Ersanli, Murat/0000-0003-1847-3087; Muenzel, Thomas/0000-0001-5503-4150; Sandhu, Manjinder/0000-0003-2538-2079; Taskinen, Marja-Riitta/0000-0002-6229-3588; bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Abbate, Antonio/0000-0002-1930-785X; STEG, Philippe Gabriel/0000-0001-6896-2941; Szarek, Michael/0000-0002-0046-0264; Bittner, Vera/0000-0001-9456-850X; Goodman, Shaun/0000-0001-8068-2440, WOS: 000490154300015, PubMed: 31121022, Aims the third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin-kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (>= 1.8 mmol/L) despite intensive statin therapy. in a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77-0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77-0.99; P = 0.032) and Type 2 (0.77, 0.61-0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. the data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types., Sanofi; Regeneron Pharmaceuticals, Supported by Sanofi and Regeneron Pharmaceuticals.

Published
2019

179. Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome

Author

Kalantar-Zadeh, Kamyar, Schwartz, Gregory G., Nicholls, Stephen J., Buhr, Kevin A., Ginsberg, Henry N., Johansson, Jan O., Kulikowski, Ewelina, Lebioda, Kenneth, Toth, Peter P., Wong, Norman, Sweeney, Michael, Ray, Kausik K., Ray, Kausik K., Schwartz, Gregory G., Nicholls, Stephen J., Kalantar-Zadeh, Kaymar, Toth, Peter, Ginsberg, Henry, Sweeney, Michael, Wong, Norman, Johansson, Jan, Lorenzatti, Alberto, Vico, Marisa, Milanova, Maria, Milicevic, Goran, Popovic, Zeljko, Ebelt, Henning, Kiss, Róbert Gábor, Lewis, Basil, Llamas, Edmundo Bayram, Banach, Maciej, Tereschenko, Sergey, Pavlovic, Milan, Pella, Daniel, Chiang, Chern-En, Lonn, Eva, Watkins, Paul, Waters, David, Szarek, Michael, Currier, Judith, Leiter, Lawrence Alan, McMurray, John, Petrie, Mark, Jhund, Pardeep, Walters, Matthew, Connolly, Eugene, Lang, Ninian, Schiavi, Lilia, Vico, Marisa, Maffei, Laura, Bordonava, Anselmo, Prado, Aldo, Vallejos, Julio, Farias, Javier, Nardone, Lucrecia, Resk, Jorge, Caruso, Orlando, Lorenzatti, Alberto, Maldonado, Natacha, Padilla, Lucio, Hominal, Miguel, Luquez, Hugo, Sposetti, Georgina, Caccavo, Alberto, Glenny, Jorge, Mansilla, Virginia, Alvarez, Maria, Parody, Maria, Sarjanovich, Rodolfo, Klyver, Maria, Valdez, Maria Eugenia, Colombo, Hugo, Baccaro, Claudia, Visco, Virginia, Bono, Julio, Cuneo, Carlos, Pácora, Fredy Ferré, Guzman, Pablo, Piskorz, Daniel, Vogel, Daniel, Grigorov, Mladen, Gatzov, Plamen, Stoyanov, Miroslav, Apostolova, Emilya, Milanova, Maria, Petrov, Ivo, Angelov, Atanas, Lazov, Petar, Grigorova, Valentina, Yanev, Todor, Vuchkova, Emilena, Vassilev, Dobrin, Tisheva, Snezhanka, Gelev, Valeri, Canecki-Varzic, Silvia, Popovic, Zeljko, Tusek, Srecko, Šunić, Ema Drvodelić, Milicevic, Goran, Jandric-Balen, Marica, Marinic, Nikolina, Moser, Natasa, Ebelt, Henning, Natour, Mohammed, Schwimmbeck, Peter, Appel, Karl-Friedrich, Kleinertz, Klaus, Merkely, Béla, Papp, András, Kiss, Robert, Kovács, Zsolt, Vértes, András, Sárszegi, Zsolt, Kis, Ernö, Benedek, Amália, Takács, János, Papp, Aniko, Matoltsy, Andras, Andrassy, Peter, Ungi, Imre, Shechter, Michael, Atar, Shaul, Shotan, Avraham, Vazan, Alicia, Alcalai, Ronny, Lotan, Chaim, Lewis, Basil, Hayek, Tony, Moriel, Mady, Katz, Amos, Liberty, Idit, Harman-Boehm, Ilana, Schiff, Elad, Kracoff, Oscar, Rozenman, Yoseph, Mosseri, Morris, Slezak, Ladislav, Sabbah, Muhammad, Zeltser, David, Adawi, Khaled, Omary, Muhamed, Ness, Rosane Abramof, Adawi, Faiad, Ruiz, Jose Garza, Carrillo, Jorge, Nevarez Ruiz, Luis Alejandro, Hernandez, Pedro Garcia, Arechavaleta-Granell, Maria, los Rios Ibarra, Manuel De, Velasco-Sanchez, Raul, Molina, Hugo Laviada, Morales, Lucas Solis, Gonzalez, Efrain Montano, Esperón, Guillermo Llamas, Bayram Llamas, Edmundo Alfredo, Rocha, Cynthia Mustieles, Suarez-Otero, Rodrigo, Real, Manuel Aguilera, Cruz, Eliud Montes, Lopez, Humberto Alvarez, Vaca, Susano Lara, Fanghanel-Salmon, Guillermo, Herrera, Carlos Hernandez, Saldaña, Joel Rodriguez, Garcia, Elier Pedroza, Velázquez, Maricela Vidrio, Briones, Ignacio Rodriguez, Hamer, Bas, Slagboom, Ton, Zurakowski, Aleksander, Debinski, Marcin, Kobielusz-Gembala, Iwona, Bartkowiak, Radoslaw, Rajzer, Marek, Witkowski, Adam, Kowalisko, Alicja, Piepiorka, Marek, Stania, Karol, Domzal, Michal, Korecki, Janusz, Korzeniak, Romuald, Mazurkiewicz, Lukasz, Mirek-Bryniarska, Ewa, Banach, Maciej, Madziarska, Katarzyna, Mlodziankowski, Adam, Rewerska, Barbara, Gaciong, Zbigniew, Mazurkiewicz, Maciej, Maksimov, Ivan, Shvarts, Yuri, Khaisheva, Larisa, Samitin, Vasily, Boldueva, Svetlana, Zykov, Mikhail, Barbarash, Olga, Kostenko, Victor, Kulibaba, Elena, Smolenskaya, Olga, Tarasov, Nikolay, Shogenov, Zaur, Strongin, Leonid, Kuzin, Anatoly, Makukhin, Valeriy, Nikolaev, Konstantin, Tereschenko, Sergey, Vezikova, Natalya, Miloradovic, Vladimir, Pavlovic, Milan, Ilic, Marina Deljanin, Simic, Dragan, Pudar-Brankovic, Georgina, Jozic, Tanja, Dodic, Slobodan, Ristic, Arsen, Hinic, Sasa, Mitov, Vladimir, Stokuca-Korac, Natasa, Stokic, Edita, Celic, Vera, Despotovic, Nebojsa, Dincic, Dragan, Tosic, Biljana Putnikovic, Selakovic, Aleksandar, Pella, Daniel, Banik, Milan, Fedacko, Jan, Micko, Karol, Duris, Tibor, Kokles, Martin, Lachova, Beata, Dzupina, Andrej, Mazur, Juraj, Buganova, Ingrid, Behuncik, Milan, Vadinova, Silvia, Yeh, Hung-I, Chiang, Chern-En, Lee, Cheng-Hen, Hsieh, I-Chang, Jiunn-Lee, Lin, Lin, We-Hsiang, Wu, Yen-Wen, Hsia, Chien Hsun, and Lo, Ping Han

Published
2021
Full Text
View/download PDF

180. Transesophageal echocardiography in rats using an intravascular ultrasound catheter

Author

Lu, Li, Ko, Eitetsu, Schwartz, Gregory G., and Chou, Tony M.

Subjects
Transesophageal echocardiography -- Methods, Rats -- Physiological aspects, Heart ventricle, Left -- Analysis, Intravascular ultrasonography -- Usage, Biological sciences
Abstract

A commercially available intravascular ultrasound system (IVUS) was used to conduct transesophageal echocardiography on anesthetized rats. The results indicate that IVUS instrumentation may be a satisfactory alternative method in the accurate, serial assessment of left ventricle dimensions, mass and systolic function. Moreover, IVUS may be applicable in the imaging of great vessels in small laboratory animals.

Published
1997

184. Evaluation of the dual peroxisome proliferator–activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: Rationale and design of the AleCardio trial

Author

Lincoff, Michael A., Tardif, Jean-Claude, Neal, Bruce, Nicholls, Stephen J., Rydén, Lars, Schwartz, Gregory G., Malmberg, Klas, Buse, John B., Henry, Robert R., Wedel, Hans, Weichert, Arlette, Cannata, Ruth, and Grobbee, Diederick E.

Published
2013
Full Text
View/download PDF

187. Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial

Author

80359786, Szarek, Michael, White, Harvey D., Schwartz, Gregory G., Alings, Marco, Bhatt, Deepak L., Bittner, Vera A., Chiang, Chern-En, Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, J. Wouter, Kimura, Takeshi, Kiss, Robert Gabor, Lecorps, Guillaume, Mahaffey, Kenneth W., Moryusef, Angèle, Pordy, Robert, Roe, Matthew T., Tricoci, Pierluigi, Xavier, Denis, Zeiher, Andreas M., Steg, Ph. Gabriel, 80359786, Szarek, Michael, White, Harvey D., Schwartz, Gregory G., Alings, Marco, Bhatt, Deepak L., Bittner, Vera A., Chiang, Chern-En, Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, J. Wouter, Kimura, Takeshi, Kiss, Robert Gabor, Lecorps, Guillaume, Mahaffey, Kenneth W., Moryusef, Angèle, Pordy, Robert, Roe, Matthew T., Tricoci, Pierluigi, Xavier, Denis, Zeiher, Andreas M., and Steg, Ph. Gabriel

Abstract

Background: The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute coronary syndrome (ACS) in 18, 924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths. Objectives: This pre-specified analysis determined the extent to which alirocumab reduced total (first and subsequent) nonfatal cardiovascular events and all-cause deaths in ODYSSEY OUTCOMES. Methods: Hazard functions for total nonfatal cardiovascular events (myocardial infarction, stroke, ischemia-driven coronary revascularization, and hospitalization for unstable angina or heart failure) and death were jointly estimated, linked by a shared frailty accounting for patient risk heterogeneity and correlated within-patient nonfatal events. An association parameter also quantified the strength of the linkage between risk of nonfatal events and death. The model provides accurate relative estimates of nonfatal event risk if nonfatal events are associated with increased risk for death. Results: With 3, 064 first and 5, 425 total events, 190 fewer first and 385 fewer total nonfatal cardiovascular events or deaths were observed with alirocumab compared with placebo. Alirocumab reduced total nonfatal cardiovascular events (hazard ratio: 0.87; 95% confidence interval: 0.82 to 0.93) and death (hazard ratio: 0.83; 95% confidence interval: 0.71 to 0.97) in the presence of a strong association between nonfatal and fatal event risk. Conclusions: In patients with ACS, the total number of nonfatal cardiovascular events and deaths prevented with alirocumab was twice the number of first events prevented. Consequently, total event reduction is a more comprehensive metric to capture the totality of alirocumab clinical efficacy after ACS.

Published
2019

188. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.

Author

Ray, Kausik K, Ray, Kausik K, Colhoun, Helen M, Szarek, Michael, Baccara-Dinet, Marie, Bhatt, Deepak L, Bittner, Vera A, Budaj, Andrzej J, Diaz, Rafael, Goodman, Shaun G, Hanotin, Corinne, Harrington, Robert A, Jukema, J Wouter, Loizeau, Virginie, Lopes, Renato D, Moryusef, Angèle, Murin, Jan, Pordy, Robert, Ristic, Arsen D, Roe, Matthew T, Tuñón, José, White, Harvey D, Zeiher, Andreas M, Schwartz, Gregory G, Steg, Philippe Gabriel, Ray, Kausik K, Ray, Kausik K, Colhoun, Helen M, Szarek, Michael, Baccara-Dinet, Marie, Bhatt, Deepak L, Bittner, Vera A, Budaj, Andrzej J, Diaz, Rafael, Goodman, Shaun G, Hanotin, Corinne, Harrington, Robert A, Jukema, J Wouter, Loizeau, Virginie, Lopes, Renato D, Moryusef, Angèle, Murin, Jan, Pordy, Robert, Ristic, Arsen D, Roe, Matthew T, Tuñón, José, White, Harvey D, Zeiher, Andreas M, Schwartz, Gregory G, and Steg, Philippe Gabriel

Abstract

After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4-1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes.ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1-12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65-1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)-defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose-and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. O

Published
2019

189. Effect of BET Protein Inhibition With Apabetalone on Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Diabetes - Results of the BETonMACE Trial

Author

Ray, Kausik K, Ray, Kausik K, Nicholls, Stephen J, Ginsberg, Henry N, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Toth, Peter P, Wong, Norman, Sweeney, Michael, Schwartz, Gregory G, Ray, Kausik K, Ray, Kausik K, Nicholls, Stephen J, Ginsberg, Henry N, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Toth, Peter P, Wong, Norman, Sweeney, Michael, and Schwartz, Gregory G

Published
2019

190. Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease.

Author

Haarhaus, Mathias, Haarhaus, Mathias, Ray, Kausik K, Nicholls, Stephen J, Schwartz, Gregory G, Kulikowski, Ewelina, Johansson, Jan O, Sweeney, Michael, Halliday, Christopher, Lebioda, Kenneth, Wong, Norman, Brandenburg, Vincent, Beddhu, Srinivasan, Tonelli, Marcello, Zoccali, Carmine, Kalantar-Zadeh, Kamyar, Haarhaus, Mathias, Haarhaus, Mathias, Ray, Kausik K, Nicholls, Stephen J, Schwartz, Gregory G, Kulikowski, Ewelina, Johansson, Jan O, Sweeney, Michael, Halliday, Christopher, Lebioda, Kenneth, Wong, Norman, Brandenburg, Vincent, Beddhu, Srinivasan, Tonelli, Marcello, Zoccali, Carmine, and Kalantar-Zadeh, Kamyar

Abstract

BACKGROUND AND AIMS:In patients with cardiovascular disease, considerable residual risk remains despite evidence-based secondary prevention measures. Alkaline phosphatase (ALP) has been suggested as a modifiable cardiovascular risk factor. We sought to determine whether cardiovascular risk reduction by the bromodomain and extra-terminal (BET) protein inhibitor apabetalone is associated with the concomitant lowering of serum ALP. METHODS:In a post-hoc analysis of 795 patients with established coronary heart disease and statin treatment, who participated in phase 2 placebo-controlled trials of apabetalone, we determined the effect of assigned treatment for up to 24 weeks on the incidence of major adverse cardiovascular events (MACE) and serum ALP. RESULTS:Baseline ALP (median 72 U/L) predicted MACE (death, non-fatal myocardial infarction, coronary revascularization, or hospitalization for cardiovascular causes), independent of high-sensitivity C-reactive protein (hsCRP), sex, age, race, study, cardiovascular risk factors, chronic kidney disease (CKD), liver function markers and treatment allocation (hazard ratio [HR] per standard deviation [SD] 1.6, 95% CI 1.19-2.16, p = 0.002). Mean placebo-corrected decreases in ALP from baseline were 9.2% (p < 0.001) after 12-14 weeks and 7.7% (p < 0.001) after 24-26 weeks of apabetalone treatment. In the apabetalone group, a 1-SD reduction in ALP was associated with a HR for MACE of 0.64 (95% CI 0.46-0.90, p = 0.009). CONCLUSIONS:Serum ALP predicts residual cardiovascular risk, independent of hsCRP, established cardiovascular risk factors and CKD, in patients with cardiovascular disease on statin treatment. Apabetalone lowers serum ALP, which was associated with a lower risk of cardiovascular events. Whether the beneficial cardiovascular effects of apabetalone are causally related to ALP reduction remains undetermined.

Published
2019

191. Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial.

Author

Ray, Kausik K, Ray, Kausik K, Nicholls, Stephen J, Ginsberg, Henry D, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Toth, Peter P, Wong, Norman, Cummings, Jeffrey L, Sweeney, Michael, Schwartz, Gregory G, Ray, Kausik K, Ray, Kausik K, Nicholls, Stephen J, Ginsberg, Henry D, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Toth, Peter P, Wong, Norman, Cummings, Jeffrey L, Sweeney, Michael, and Schwartz, Gregory G

Abstract

After an acute coronary syndrome (ACS), patients with diabetes remain at high risk for additional cardiovascular events despite use of current therapies. Bromodomain and extra-terminal (BET) proteins are epigenetic modulators of inflammation, thrombogenesis, and lipoprotein metabolism implicated in atherothrombosis. The BETonMACE trial tests the hypothesis that treatment with apabetalone, a selective BET protein inhibitor, will improve cardiovascular outcomes in patients with diabetes after an ACS. DESIGN: Patients (n = 2425) with ACS in the preceding 7 to 90 days, with type 2 diabetes and low HDL cholesterol (≤40 mg/dl for men, ≤45 mg/dl for women), receiving intensive or maximum-tolerated therapy with atorvastatin or rosuvastatin, were assigned in double-blind fashion to receive apabetalone 100 mg orally twice daily or matching placebo. Baseline characteristics include female sex (25%), myocardial infarction as index ACS event (74%), coronary revascularization for index ACS (80%), treatment with dual anti-platelet therapy (87%) and renin-angiotensin system inhibitors (91%), median LDL cholesterol 65 mg per deciliter, and median HbA1c 7.3%. The primary efficacy measure is time to first occurrence of cardiovascular death, non-fatal myocardial infarction, or stroke. Assumptions include a primary event rate of 7% per annum in the placebo group and median follow-up of 1.5 years. Patients will be followed until at least 250 primary endpoint events have occurred, providing 80% power to detect a 30% reduction in the primary endpoint with apabetalone. SUMMARY: BETonMACE will determine whether the addition of the selective BET protein inhibitor apabetalone to contemporary standard of care for ACS reduces cardiovascular morbidity and mortality in patients with type 2 diabetes. Results are expected in 2019.

Published
2019

192. ALP Levels Predict Adverse Cardiovascular Outcomes and Cognitive Impairment in High Risk Patients

Author

Ray, Kausik K, Ray, Kausik K, Cummings, Jeffrey L, Haarhaus, Mathias L, Toth, Peter P, Nicholls, Stephen, Ginsberg, Henry N, Winblad, Bengt, Zetterberg, Henrik, Sweeney, Michael, Johansson, Jan O, Kulikowski, Ewelina, Lebioda, Kenneth, Khan, Aziz, Halliday, Christopher, Zoccali, Carmine, Kalantar-Zadeh, Kamyar, Schwartz, Gregory G, Ray, Kausik K, Ray, Kausik K, Cummings, Jeffrey L, Haarhaus, Mathias L, Toth, Peter P, Nicholls, Stephen, Ginsberg, Henry N, Winblad, Bengt, Zetterberg, Henrik, Sweeney, Michael, Johansson, Jan O, Kulikowski, Ewelina, Lebioda, Kenneth, Khan, Aziz, Halliday, Christopher, Zoccali, Carmine, Kalantar-Zadeh, Kamyar, and Schwartz, Gregory G

Published
2019

193. Effect of alirocumab on mortality after acute coronary syndromes : an analysis of the ODYSSEY OUTCOMES randomized clinical trial

Author

Rushton-Smith, Sophie, ODYSSEY OUTCOMES Committees and Investigators, Steg, P. Gabriel, Szarek, Michael, Bhatt, Deepak L., Bittner, Vera A., Brégeault, Marie-France, Dalby, Anthony J., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, J. Wouter, Lecorps, Guillaume, Mahaffey, Kenneth, Moryusef, Angèle, Ostadal, Petr, Parkhomenko, Alexander, Pordy, Robert, Roe, Matthew T., Tricoci, Pierluigi, Vogel, Robert, White, Harvey, Zeiher, Andreas M., Schwartz, Gregory G., Rushton-Smith, Sophie, ODYSSEY OUTCOMES Committees and Investigators, Steg, P. Gabriel, Szarek, Michael, Bhatt, Deepak L., Bittner, Vera A., Brégeault, Marie-France, Dalby, Anthony J., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Jukema, J. Wouter, Lecorps, Guillaume, Mahaffey, Kenneth, Moryusef, Angèle, Ostadal, Petr, Parkhomenko, Alexander, Pordy, Robert, Roe, Matthew T., Tricoci, Pierluigi, Vogel, Robert, White, Harvey, Zeiher, Andreas M., and Schwartz, Gregory G.

Abstract

Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥1

Published
2019

194. Alirocumab in patients with polyvascular disease and recent acute coronary syndrome: ODYSSEY OUTCOMES Trial

Author

Rushton-Smith, Sophie, ODYSSEY OUTCOMES Committees and Investigators, Jukema, J. Wouter, Szarek, Michael, Zijlstra, Laurien E., De Silva, Hithanadura Asita, Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Karpov, Yuri, Moryusef, Angèle, Pordy, Robert, Prieto, Juan C., Roe, Matthew T., White, Harvey, Zeiher, Andreas M., Schwartz, Gregory G., Steg, P. Gabriel, Rushton-Smith, Sophie, ODYSSEY OUTCOMES Committees and Investigators, Jukema, J. Wouter, Szarek, Michael, Zijlstra, Laurien E., De Silva, Hithanadura Asita, Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Edelberg, Jay M., Goodman, Shaun G., Hanotin, Corinne, Harrington, Robert A., Karpov, Yuri, Moryusef, Angèle, Pordy, Robert, Prieto, Juan C., Roe, Matthew T., White, Harvey, Zeiher, Andreas M., Schwartz, Gregory G., and Steg, P. Gabriel

Abstract

Background: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin–kexin type 9 inhibition in such patients is undetermined. Objectives: This pre-specified analysis from ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) determined whether polyvascular disease influenced risks of MACEs and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy. Methods: Patients were randomized to alirocumab or placebo 1 to 12 months after ACS. The primary MACEs endpoint was the composite of coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. Results: Median follow-up was 2.8 years. Of 18,924 patients, 17,370 had monovascular (coronary) disease, 1,405 had polyvascular disease in 2 beds (coronary and peripheral artery or cerebrovascular), and 149 had polyvascular disease in 3 beds (coronary, peripheral artery, cerebrovascular). With placebo, the incidence of MACEs by respective vascular categories was 10.0%, 22.2%, and 39.7%. With alirocumab, the corresponding absolute risk reduction was 1.4% (95% confidence interval [CI]: 0.6% to 2.3%), 1.9% (95% CI: −2.4% to 6.2%), and 13.0% (95% CI: −2.0% to 28.0%). With placebo, the incidence of death by respective vascular categories was 3.5%, 10.0%, and 21.8%; the absolute risk reduction with alirocumab was 0.4% (95% CI: −0.1% to 1.0%), 1.3% (95% CI: −1.8% to 4.3%), and 16.2% (95% CI: 5.5% to 26.8%). Conclusions: In patients with recent ACS and dyslipidemia despite intensive statin therapy, polyvascular disease is associated with high risks of MACEs and death. The large absolute reductions in those risks with

Published
2019

195. Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial.

Author

Cummings, Jeffrey, Schwartz, Gregory G., Nicholls, Stephen J., Khan, Aziz, Halliday, Chris, Toth, Peter P., Sweeney, Michael, Johansson, Jan O., Wong, Norman C.W., Kulikowski, Ewelina, Kalantar-Zadeh, Kamyar, Lebioda, Kenneth, Ginsberg, Henry N., Winblad, Bengt, Zetterberg, Henrik, and Ray, Kausik K.

Subjects
*MONTREAL Cognitive Assessment, *COGNITIVE analysis, *ALZHEIMER'S disease, *VASCULAR dementia, *SMALL molecules, *MILD cognitive impairment, *QUINONE, *RESEARCH, *RESEARCH methodology, *CARDIOVASCULAR diseases, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *GENES, *RESEARCH funding, *DISEASE complications
Abstract

Background: Epigenetic changes may contribute importantly to cognitive decline in late life including Alzheimer's disease (AD) and vascular dementia (VaD). Bromodomain and extra-terminal (BET) proteins are epigenetic "readers" that may distort normal gene expression and contribute to chronic disorders.Objective: To assess the effects of apabetalone, a small molecule BET protein inhibitor, on cognitive performance of patients 70 years or older participating in a randomized trial of patients at high risk for major cardiovascular events (MACE).Methods: The Montreal Cognitive Assessment (MoCA) was performed on all patients 70 years or older at the time of randomization. 464 participants were randomized to apabetalone or placebo in the cognition sub-study. In a prespecified analysis, participants were assigned to one of three groups: MoCA score≥26 (normal performance), MoCA score 25-22 (mild cognitive impairment), and MoCA score≤21 (dementia). Exposure to apabetalone was equivalent in the treatment groups in each MoCA-defined group.Results: Apabetalone was associated with an increased total MoCA score in participants with baseline MoCA score of≤21 (p = 0.02). There was no significant difference in change from baseline in the treatment groups with higher MoCA scores. In the cognition study, more patients randomized to apabetalone discontinued study drug for adverse effects (11.3% versus 7.9%).Conclusion: In this randomized controlled study, apabetalone was associated with improved cognition as measured by MoCA scores in those with baseline scores of 21 or less. BET protein inhibitors warrant further investigation for late life cognitive disorders. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

198. Inhibition of fatty acid metabolism alters myocardial high-energy phosphates in vivo

Author

Schwartz, Gregory G., Greyson, Clifford, Wisneski, Judith A., and Garcia, Jorge

Subjects
Fatty acid metabolism -- Physiological aspects, Phosphates -- Physiological aspects, Heart muscle -- Research, Biological sciences
Abstract

Inhibition of free fatty acid (FFA) metabolism offsets a rise in the ratio of phosphocreatine (Pcr) to ATP due to isoproterenol (ISO) or high arterial FFA. Variations in myocardial high-energy phosphate levels during hemodynamics and pharmacological interventions require the consideration of prevailing substrate utilization. Conditions that enhance FFA uptake cause increased Pcr/ATP.

Published
1994

199. Relation among regional O2 consumption, high-energy phosphates, and substrate uptake in porcine right ventricle

Author

Schwartz, Gregory G., Greyson, Clifford R., Wisneski, Judith A., Garcia, Jorge, and Steinman, Sean

Subjects
Energy metabolism -- Analysis, Heart -- Blood-vessels, Blood circulation -- Analysis, Biological sciences
Abstract

Multifactorial regulation of right ventricle (RV) oxidative phosphorylation in vivo is validated. During pulmonary artery constriction (PAC), elevated free ADP concentration could have activated oxidative phosphorylation. Uptake of free fatty acid was over three times lower with PAC than with isoproterenol infusion.

Published
1994

200. Atorvastatin for Acute Coronary Syndromes

Author

Schwartz, Gregory G., Olsson, Anders G., Ezekowitz, Michael D., Ganz, Peter, Oliver, Michael F., Waters, David, Zeiher, Andreas, and Chaitman, Bernard R.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results