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Effects of alirocumab on types of myocardial infarction : insights from the ODYSSEY OUTCOMES trial
Authors :
White, Harvey D. Steg, Ph. Gabriel Harrington, Robert A. Endsley, Patricia Gusi Tragant, Gabriel Benedicto, Amparo Gonzalez-Juanatey, Carlos Camprubi Potau, Mercedes Plaza Perez, Ignacio Moris De La Tassa, Cesar Loma-Osorio Rincon, Pablo Balaguer Recena, Javier M Escudier, Juan Constantine, Godwin Eppinger, Arleen Haniffa, Ruvaiz Tissera, Nirmali Amarasekera, Stanley Fernando, Nimali Jayawardena, Jayanthimala Santharaj, Wijeyasingam Ekanayaka, Ruvan Mendis, Sepalika Senaratne, Vajira Mayurathan, Gnanamoorthy Hess, Connie Ng Sirisena, Thilak Rajapaksha, Ajantha Herath, Jagath I. Amarasena, Naomali Berglund, Stefan Rasmanis, Gundars Hagstrom, Emil Witt, Nils Mourtzinis, Georgios Nicol, Peter Hlatky, Mark A. Hansen, Ole Romeo, Stefano Jensen, Steen Agergaard Torstensson, Ingemar Ahremark, Ulf Sundelin, Torbjorn Moccetti, Tiziano Mueller, Christian Mach, Francois Jordan, Joseph Dedrick Binder, Ronald Chiang, Chern-En Tsai, Wei-Chuan Ueng, Kwo-Chang Lai, Wen-Ter Liu, Ming-En Hwang, Juey-Jen Yin, Wei-Hsian Hsieh, I. Chang Lin, Wei Hsiang Knowles, Joshua W. Kuo, Jen-Yuan Huang, Tsuei-Yuan Fang, Chih-Yuan Kaewsuwanna, Pinij Soonfuang, Wasant Jintapakorn, Woravut Sukonthasarn, Apichard Sritara, Piyamitr Wongpraparut, Nattawut Sastravaha, Krisada Kolls, Bradley J. Sansanayudh, Nakarin Kehasukcharoen, Wirash Piyayotai, Dilok Camsari, Ahmet Kultursay, Hakan Guneri, Sema Mutlu, Bulent Ersanli, Murat Demirtas, Mustafa Kirma, Cevat Kong, David F. Ural, Ertan Koldas, Lale Karpenko, Oleksandr Prokhorov, Alexander Vakaluyk, Ihor Myshanych, Halyna Reshotko, Dmytro Batushkin, Valeriy Rudenko, Leonid Kovalskyi, Ihor Leonardi, Sergio Kushnir, Mykola Tseluyko, Vira Mostovoy, Yuriy Stanislavchuk, Mykola Kyiak, Yulian Karpenko, Yuriy Malynovsky, Yaroslav Klantsa, Andriy Kutniy, Oles Amosova, Ekaterina Lillis, Linda Tashchuk, Viktor Leshchuk, Oleh Parkhomenko, Alexander Rishko, Mykola Kopytsya, Mykola Yagensky, Andriy Vatutin, Mykola Bagriy, Andriy Barna, Olga M. Ushakov, Olexiy Jukema, J. Wouter Lopes, Renato D. Dzyak, Georgiy Goloborodko, Borys Rudenko, Anatolii Trevelyan, Jasper Zaman, Azfar Lee, Kaeng Moriarty, Andrew Aggarwal, Rajesh K. Clifford, Piers Wong, Yuk-Ki Maron, David J. Iqbal, Syed M. R. Subkovas, Eduardas Braganza, Denise Sarkar, David Storey, Robert Griffiths, Huw Mcclure, Sam Muthusamy, Rangasamy Kurian, John Levy, Terry Marcus, Jill Barr, Craig Kadr, Honer Gerber, Robert Simaitis, Audrius Soran, Handrean Mathur, Anthony Brodison, Adrian Oliver, Richard Mudawi, Telal Reynolds, Timothy Mathews, Robin Sharman, David Butler, Rob Wilkinson, Peter Lip, Gregory Y. H. Halcox, Julian Vardi, Gil Baldari, Duccio Brabham, David Treasure, Charles Dahl, Charles Mehta, Rajendra H. Palmer, Bruce Wiseman, Alan Khan, Abul Puri, Sanjeev Mohart, Ann Elizabeth Ince, Carlos Flores, Enrique Wright, Scott Cheng, Shi-Chi Rosenberg, Michael Mentz, Robert J. Rogers, William Jr. Kosinski, Edward Forgosh, Les Waltman, Jonathan Khan, Misal Shoukfeh, Mohammad Dagher, Georges Lieber, Ira Kumar, Priya East, Cara Moreira, Humberto Graner Krichmar, Perry White, Lindsey Knickelbine, Thomas Haldis, Thomas Gillespie, Eve Suh, David Arif, Imran Akhter, Faiq Carlson, Eric D'Urso, Michael Patel, Chetan B. El-Ahdab, Fadi Nelson, William Harris, Barry Cohen, Steven Carter, Luther Sabatino, Kenneth Haddad, Tariq Malik, Amir Rao, Sunder Mulkay, Angel Pereira, Sabrina Bernardez Jovin, Ion Klancke, Kim Malhotra, Vinay Devarapalli, Sai K. Koren, Michael Chandna, Harish Dodds, George Janik, Matthew Moran, Joseph Sumner, Andrew Perkins, Lynn Kobayashi, John Davis, William Yazdani, Shahram Pasquini, John Thakkar, Maitreya Vedere, Amarnath Leimbach, Wayne Rider, James Singh, Narendra Shah, Anil V. Povsic, Thomas J. Moriarty, Patrick M. Janosik, Denise Pepine, Carl Berman, Brett Gelormini, Joseph Daniels, Christopher Keating, Friederike Kondo, Nicholas I. Shetty, Sanjay Waider, Winfried Puymirat, Etienne Takata, Theodore Abu-Fadel, Mazen Shah, Vipul Aggarwal, Rahul Izzo, Mark Kumar, Anil Hattler, Brack Link, Chad Bortnick, Anna Kinzfogl, George Jones, William Schuyler Ghitis, Arnold Larry, John Teufel, Edward Kuhlman, Peter Mclaurin, Brent Zhang, Wenwu Thew, Stephen Abbas, Jalal White, Matthew Ranadive, Nandkishore Shah, Bimal R. Gring, Christian Henderson, David Schuchard, Timothy Farhat, Naim Kline, Geoffrey Mahal, Sharan Whitaker, Jack Speirs, Shawn Andersen, Rolf Daboul, Nizar Sherwood, Matthew W. Horwitz, Phillip Jafar, Zubair Mcgarvey, Joseph Jr. Panchal, Vipul Voyce, Stephen Blok, Thomas Sheldon, William Azizad, Masoud M. Schmalfuss, Carsten Picone, Mark Stringfellow, Kenya Herzog, William Jr. Lindsey, Jason Nowins, Rosemary Lepor, Norman El Shahawy, Mahfouz Weintraub, Howard Irimpen, Anand May, Wade Galski, Thomas Chu, Alan Sujjavanich, Darin Mody, Freny Hodes, Zachary Fairlamb, James Lambert, Charles Jr. Raisinghani, Ajit Abbate, Antonio King, Marilyn Carey, Charles Gerber, Jaime Younis, Liwa Toma, Mustafa Park, Hyeun (Tom Vidovich, Mladen Knutson, Thomas Friedman, Dennis Chaleff, Fred Loussararian, Arthur Kimmelstiel, Carey Silver, Kevin Foster, Malcolm Tonnessen, Glen Trotter, Charlene Amlani, Mohamadali Wali, Andreas Malozzi, Christopher Wattanakit, Keattiyoat O'Donnell, Philip J. Singal, Dinesh Jaffrani, Naseem Banuru, Sridhar Fisher, Daniel Xenakis, Mark van Diepen, Sean F. P. Perlmutter, Neal Bhagwat, Ravi Strader, James Jr. Akyea-Djamson, Ayim Labroo, Ajay Lee, Kwan Marais, H. John Claxton, Edmund Jr. Berk, Martin Rossi, Peter Mahaffey, Kenneth W. Wilson, Matthew D. Joshi, Parag Khaira, Ajit S. Kumkumian, Greg Lupovitch, Steven Purow, Joshua Welka, Stephen Hoffman, David Fischer, Stuart Soroka, Eugene Eagerton, Donald Yan, Andrew Tze-Kay Pancholy, Samir Ray, Michael Farrar, Michael Pollock, Stewart French, William J. Diamantis, Steve Gimple, Lawrence Schwartz, Steven Pereira, Edward Spriggs, Douglas Schiavi, Lilia B. Strain, Janet Vo, Anthony Chane, Majed Hall, Jason Vijay, Nampalli Lotun, Kapildeo Lester, F. Martin Nahhas, Ahed Pope, Theodore Nager, Paul Garrido, Marcelo Vohra, Rakesh Bashir, Riyaz Ahmed, Hinan Berlowitz, Michael Fishberg, Robert Barrucco, Robert Yang, Eric Radin, Michael Sporn, Daniel Eisenberg, Steven Alvarisqueta, Andres F. Landzberg, Joel Mcgough, Martin Turk, Samir Schwartz, Michael Sundram, P. Sandy Jain, Diwakar Zainea, Mark Bayron, Carlos Karlsberg, Ronald Lui, Henry Sassone, Sonia A. Keen, William Westerhausen, Donald Jr. Khurana, Sandeep Agarwal, Himanshu Birchem, Jessica Penny, William Jr. Chang, Mark Gilbert, John M. Chalavarya, Gopal Eaton, Charles Bordonava, Anselmo P. Schmedtje, John F. Jr. Christenson, Stuart Denham, Douglas Macdonell, Alexander Gibson, Paul Rahman, Aref Al Joundi, Tammam Conrad, Gary Kotha, Purushotham Love, Michael Alves De Lima, Alberto E. Giesler, Gregory Rubenstein, Howard Akright, Laura Schifferdecker, Branislav Krawczyk, Justine Wells, Terry Welker, James Foster, Robert Gilmore, Richard Anderson, Jay Schmidberg, Jorge M. Jacoby, Douglas Harris, Bill Gardner, Geraldine Dandillaya, Ramprasad Vora, Kishor Kostis, John Hunter, John Laxson, David Ball, Eric Duronto, Ernesto A. Moryusef, Angele Caruso, Orlando C. Novaretto, Leonardo P. Angel Hominal, Miguel Montana, Oscar R. Caccavo, Alberto Gomez Vilamajo, Oscar A. Lorenzatti, Alberto J. Cartasegna, Luis R. Paterlini, Gustavo A. Mackinnon, Ignacio J. Pordy, Robert Caime, Guillermo D. Amuchastegui, Marcos Codutti, Oscar R. Jure, Horacio O. Bono, Julio O. E. Hrabar, Adrian D. Vallejos, Julio A. Ahuad Guerrero, Rodolfo A. Novoa, Federico Patocchi, Cristian A. Roe, Matthew T. Zaidman, Cesar J. Giuliano, Maria E. Dran, Ricardo D. Vico, Marisa L. Carnero, Gabriela S. Guzman, Pablo N. Medrano Allende, Juan C. Garcia Brasca, Daniela F. Bustamante Labarta, Miguel H. Nani, Sebastian Blumberg, Eduardo D. S. Colombo, Hugo R. Liberman, Alberto Luciardi, Hector L. Waisman, Gabriel D. Berli, Mario A. Garcia Duran, Ruben O. Cestari, Horacio G. Luquez, Hugo A. Giordano, Jorge A. Tricoci, Pierluigi Saavedra, Silvia S. Waites, Jonathon H. Collins, Nicholas Soward, Allan Hii, Chris L. S. Shaw, James Arstall, Margaret A. Horowitz, John Rogers, James F. Colquhoun, David Zeiher, Andreas M. Flores, Romulo E. Oqueli Roberts-Thomson, Philip Raffel, Owen Lehman, Sam J. Coverdale, Steven G. M. Garrahy, Paul J. Starmer, Gregory Sader, Mark Carroll, Patrick A. Zweiker, Robert Szarek, Michael Schwartz, Gregory G. Hoppe, Uta Huber, Kurt Berger, Rudolf Weidinger, Franz Faes, Dirk Hermans, Kurt Pirenne, Bruno Leone, Attilio Hoffer, Etienne Vrolix, Mathias C. M. Aylward, Philip E. De Wolf, Luc Wollaert, Bart Castadot, Marc Dujardin, Karl Beauloye, Christophe Vervoort, Geert Striekwold, Harry Convens, Carl Roosen, John Barbato, Emanuele Drexel, Heinz Claeys, Marc Cools, Frank Terzic, Ibrahim Barakovic, Fahir Midzic, Zlatko Pojskic, Belma Fazlibegovic, Emir Durak-Nalbantic, Azra Vulic, Dusko Muslibegovic, Adis Sinnaeve, Peter Reis, Gilmar Sousa, Luciano Nicolau, Jose C. Giorgeto, Flavio E. Silva, Ricardo P. Maia, Lilia Nigro Rech, Rafael Rossi, Paulo R. F. Cerqueira, Maria Jose A. G. Duda, Norberto Dilic, Mirza Kalil, Renato Kormann, Adrian Abrantes, Jose Antonio M. Pimentel Filho, Pedro Soggia, Ana Priscila de Santos, Mayler O. N. Neuenschwander, Fernando Bodanese, Luiz C. Michalaros, Yorghos L. Eliaschewitz, Freddy G. Vidotti, Maria H. Leaes, Paulo E. Botelho, Roberto V. Kaiser, Sergio Fernandes Manenti, Euler Roberto F. Precoma, Dalton B. Moura Jorge, Jose C. Silva, Pedro G. M. de B. Silveira, Jose A. Saporito, Wladimir Gotcheva, Nina N. Marin Neto, Jose A. Feitosa, Gilson S. Ritt, Luiz Eduardo F. de Souza, Juliana A. Costa, Fernando Souza, Weimar K. S. B. Reis, Helder J. L. Machado, Leandro Aidar Ayoub, Jose Carlos Goodman, Shaun G. Todorov, Georgi V. Nikolov, Fedya P. Velcheva, Elena S. Tzekova, Maria L. Benov, Haralambi O. Petranov, Stanislav L. Tumbev, Haralin S. Shehova-Yankova, Nina S. Markov, Dimitar T. Raev, Dimitar H. Prieto, Juan-Carlos Mollov, Mihail N. Kichukov, Kostadin N. Ilieva-Pandeva, Katya A. Ivanova, Raya Mincheva, Valentina M. Lazov, Petar V. Dimov, Bojidar I. Senaratne, Manohara Stone, James Yong, Huo Kornder, Jan Pearce, Stephen Dion, Danielle Savard, Daniel Pesant, Yves Pandey, Amritanshu Robinson, Simon Gosselin, Gilbert Vizel, Saul Hoag, Gordon Bhatt, Deepak L. Lopez-Jaramillo, Patricio Bourgeois, Ronald Morisset, Anne Sabbah, Eric Sussex, Bruce Kouz, Simon MacDonald, Paul Diaz, Ariel Michaud, Nicolas Fell, David Leung, Raymond Pecin, Ivan Vuurmans, Tycho Lai, Christopher Nigro, Frank Davies, Richard Nogareda, Gustavo Vijayaraghavan, Ram Ducas, John Lepage, Serge Mehta, Shamir Cha, James Reiner, Zeljko Dupuis, Robert Fong, Peter Rodes-Cabau, Josep Fadlallah, Hussein Cleveland, David Huynh, Thao Bata, Iqbal Hameed, Adnan Pincetti, Cristian Potthoff, Sergio Ostadal, Petr Acevedo, Monica Aguirre, Arnoldo Vejar, Margarita Yanez, Mario Araneda, Guillermo Fernandez, Mauricio Perez, Luis Varleta, Paola Florenzano, Fernando Huidobro, Laura Poulsen, Steen Hvitfeldt Raffo, Carlos A. Olivares, Claudia Chen, Jiyan Dong, Yugang Huang, Weijian Wang, Jianzhong Huang, Shi'An Yao, Zhuhua Cui, Lan Lin, Wenhua Viigimaa, Margus Sun, Yuemin Wang, Jingfeng Li, Jianping Zhang, Xuelian Zhu, Hong Chen, Dandan Huang, Lan Dong, Shaohong Su, Guohai Xu, Biao Nieminen, Markku S. Su, Xi Cheng, Xiaoshu Lin, Jinxiu Zong, Wenxia Li, Huanming Feng, Yi Xu, Dingli Yang, Xinchun Ke, Yuannan Lin, Xuefeng Danchin, Nicolas Zhang, Zheng Zheng, Zeqi Luo, Zhurong Chen, Yundai Ding, Chunhua Zheng, Yang Li, Xiaodong Peng, Daoquan Li, Ying Wei, Meng Chumburidze, Vakhtang Liu, Shaowen Yu, Yihua Qu, Baiming Jiang, Weihong Zhou, Yujie Zhao, Xingsheng Yuan, Zuyi Guo, Ying Xu, Xiping Shi, Xubo Marx, Nikolaus Ge, Junbo Fu, Guosheng Bai, Feng Fang, Weiyi Shou, Xiling Yang, Xiangjun Wang, Jian'An Jaramillo, Nicolas Vallejo, Gregorio Sanchez Botia, Diana C. Luna Bittner, Vera A. Liberopoulos, Evangelos Lopez, Rodrigo Botero De Salazar, Dora I. Molina Bonfanti, Alberto J. Cadena Higuera, Juan Diego Silva, Sandra I. Barrera Lozada, Henry J. Garcia Arroyo, Julian A. Coronel Mendoza, Jose L. Accini Ruiz, Ricardo L. Fernandez Fernandez, Angela M. Montenegro Valdovinos, Pablo Carlos Jatin, Fernando G. Manzur Herazo, Aristides Sotomayor Parada, Jeffrey Castellanos Triana, Miguel A. Urina Spinar, Jindrich Horak, David Stasek, Josef Alan, David Machova, Vilma Linhart, Ales Tse, Hung-Fat Novotny, Vojtech Kaucak, Vladimir Rokyta, Richard Naplava, Robert Coufal, Zdenek Adamkova, Vera Podpera, Ivo Zizka, Jiri Motovska, Zuzana Marusincova, Ivana Kiss, Robert Gabor Svab, Premysl Heinc, Petr Kuchar, Jiri Povolny, Petr Raungaard, Bent Clemmensen, Peter Bang, Lia E. May, Ole Bottcher, Morten Hove, Jens D. Xavier, Denis Frost, Lars Gislason, Gunnar Larsen, John Johansen, Peter Betton Hald, Flemming Jeppesen, Jorgen Nielsen, Tonny Kristensen, Kjeld S. Walichiewicz, Piotr Maria Lomholdt, Jens D. Zahger, Doron Klausen, Ib C. Nielsen, Peter Kaiser Davidsen, Flemming Videbaek, Lars Soots, Mai Vahula, Veiko Hedman, Anu Soopold, Sllar Martsin, Kaja Taskinen, Marja-Riitta Valgimigli, Marco Porthan, Kimmo Airaksinen, Juhani K. Juonala, Markus Kiviniemi, Tuomas Vikman, Saila Posio, Pirjo Taurio, Jyrki Huikuri, Heikki Kaikkonen, Kari Coste, Pierre Kimura, Takeshi Ferrari, Emile Morel, Olivier Montalescot, Gilles Barone-Rochette, Gilles Mansourati, Jacques Cottin, Yves Steg, Philippe Gabriel Leclercq, Florence Belhassane, Abdelkader Delarche, Nicolas Kim, Hyo Soo Boccara, Franck Paganelli, Franck Clerc, Jerome Schiele, Francois Aboyans, Victor Probst, Vincent Berland, Jacques Lefevre, Thierry Khintibidze, Irakli Shaburishvili, Tamaz Kim, Sang-Hyun Pagava, Zurab Ghlonti, Ramaz Lominadze, Zaza Khabeishvili, George Hemetsberger, Rayyan Rauch-Kroehnert, Ursula Stratmann, Matthias Appel, Karl-Friedrich Schmidt, Ekkehard Omran, Heyder Diaz, Rafael Erglis, Andrejs Stellbrink, Christoph Dorsel, Thomas Lianopoulos, Emmanouil Marx, Roger Zirlik, Andreas Schellenberg, Detlev Heitzer, Thomas Laufs, Ulrich Gielen, Stephan Laucevicius, Aleksandras Winkelmann, Bernhard Behrens, Steffen Sydow, Karsten Simonis, Gregor Muenzel, Thomas Werner, Nikos Leggewie, Stefan Boecker, Dirk Braun-Dullaeus, Ruediger Toursarkissian, Nicole Kedev, Sasko Jeserich, Michael Weissbrodt, Matthias Schaeufele, Tim Weil, Joachim Voeller, Heinz Waltenberger, Johannes Natour, Mohammed Steiner, Stephan Heidenreich, Lothar Gremmler, Uwe Yusoff, Khalid Killat, Holger Patsilinakos, Sotiris Kartalis, Athanasios Manolis, Athanassios Sionis, Dimitrios Skoumas, Ioannis Athyros, Vasilios Parthenakis, P. I. Frangkiskos Hahalis, P. I. Georgios Ramos Lopez, Gabriel Arturo Lekakis, John Xatzitolios, Apostolos Fausto Ovando, Sergio R. Arango Benecke, Juan L. Rodriguez De Leon, Edgar R. Yan, Bryan P. Y. Siu, David C. W. Turi, Tibor Merkely, Bela Alings, Marco Ungi, Imre Lupkovics, Geza Nagy, Lajos Katona, Andras Edes, Istvan Muller, Gabor Horvath, Ivan Kapin, Tibor Falukozy, Jozsef Halvorsen, Sigrun Kumbla, Mukund Sandhu, Manjinder Annam, Sharath Proddutur, Naveen Reddy Premchand, Rajendra K. Mahajan, Ajaykumar Abhyanakar, Atul D. Kerkar, Prafulla Govinda, Ravishankar A. Oomman, Abraham Correa Flores, Roger M. Sinha, Dhurjati Patil, Sachin N. Kahali, Dhiman Sawhney, Jitendra Joshi, Abhijeet B. Chaudhary, Sanjeev Harkut, Pankaj Guha, Santanu Porwal, Sanjay Jujjuru, Srimannarayana Sy, Rody G. Pothineni, Ramesh B. Monteiro, Minguel R. Khan, Aziz Iyengar, Shamanna S. Grewal, Jasprakash Singh Chopda, Manoj Fulwani, Mahesh C. Patange, Aparna Chopra, Vijay K. Goyal, Naresh K. Budaj, Andrzej Shinde, Rituparna Manakshe, Gajendra V. Patki, Nitin Sethi, Sumeet Munusamy, Vengatesh Karna, Sunil Adhyapak, Srilakshmi Pandurangi, Ulhas Mathur, Rishabh Kalashetti, Suhas Edelberg, Jay M. Morais, Joao Bhagwat, Ajit Raghuraman, Bagirath Yerra, Shiv Kumar Bhansali, Prasant Borse, Rohidas Das, Srihari Abdullakutty, Jabir Saathe, Shireesh Palimkar, Priya Atar, Shaul Dorobantu, Maria Shechter, Michael Mosseri, Morris Arbel, Yaron Lotan, Chaim Rosenschein, Uri Katz, Amos Henkin, Yaakov Francis, Adi Klutstein, Marc Nikolsky, Eugenia Karpov, Yuri Turgeman, Yoav Halabi, Majdi Kornowski, Ran Jonas, Michael Amir, Offer Rozenman, Yoseph Fuchs, Shmuel Hussein, Osamah Gavish, Dov Vered, Zvi Ristic, Arsen D. Caraco, Yoseph Elias, Mazen Tov, Naveh Piovaccari, Giancarlo De Pellegrin, Annamaria Guardigli, Gabriele Licciardello, Giovanni Auguadro, Carla Cuccia, Claudio Salvioni, Alessandro Chua, Terrance Musumeci, Giuseppe Calabro, Paolo Novo, Salvatore Faggiano, Pompilio De Cesare, Nicoletta B. Berti, Sergio Cavallini, Claudio Puccioni, Enrico Galvani, Marcello Tespili, Maurizio Murin, Jan Piatti, Piermarco Palvarini, Michela De Luca, Giuseppe Violini, Roberto De Leo, Alessandro Filardi, Pasquale Perrone Ferratini, Maurizio Dai, Kazuoki Kamiya, Haruo Ando, Kenji Fras, Zlatko Takeda, Yoshihiro Morino, Yoshihiro Hata, Yoshiki Kimura, Kazuo Kishi, Koichi Michishita, Ichiro Uehara, Hiroki Higashikata, Toshinori Hirayama, Atsushi Hirooka, Keiji Dalby, Anthony J. Sakagami, Satoru Taguchi, Shuichi Koike, Akihiro Fujinaga, Hiroyuki Koba, Shinji Kozuma, Ken Kawasaki, Tomohiro Ono, Yujiro Shimizu, Masatoshi Katsuda, Yousuke Tunon, Jose Wada, Atsuyuki Shinke, Toshiro Ako, Junya Fujii, Kenshi Takahashi, Toshiyuki Sakamoto, Tomohiro Furukawa, Yutaka Sugino, Hiroshi Mano, Toshiaki Utsu, Noriaki de Silva, H. Asita Ito, Kashima Haraguchi, Takuya Ueda, Yasunori Nishibe, Akira Fujimoto, Kazuteru Yoon, Jung Han Park, Hun Sik Chae, In-Ho Kim, Moo Hyun Jeong, Myung Ho Rha, Seungwoon Kim, Chongjin Hong, Taekjong Busmane, Arija Pontaga, Natalija Strelnieks, Aldis Mintale, Iveta Sime, Iveta Petrulioniene, Zaneta Kavaliauskiene, Roma Muller, Christian Jurgaitiene, Ruta Sakalyte, Gintare Slapikas, Rimvydas Norkiene, Sigute Misonis, Nerijus Kibarskis, Aleksandras Kubilius, Raimondas Bojovski, Stojko Lozance, Nensi Kjovkaroski, Aleksandar Doncovska, Snezana Ong, Tiong Kiam Kasim, Sazzli Maskon, Oteh Kandasamy, Balachandran Liew, Houng B. Mohamed, Wan Mohd Izani Wan Garcia Castillo, Armando Carrillo Calvillo, Jorge Fajardo Campos, Pedro Nunez Fragoso, Juan Carlos Bayram Llamas, Edmundo Alfredo Alcocer Gamba, Marco Antonio Carranza Madrigal, Jaime Gonzalez Salas, Luis Gerardo Lopez Rosas, Enrique Gonzalez Diaz, Belinda Salcido Vazquez, Eduardo Nacoud Ackar, Alfredo Llamas Esperon, Guillermo Antonio Martinez Sanchez, Carlos Rodolfo Guerrero De Leon, Maria Suarez Otero, Rodrigo Fanghanel Salmon, Guillermo Perez Rios, Jesus Antonio Garza Ruiz, Jose Angel Breedveld, Robert W. Hoogslag, Pieter A. M. Suryapranata, Harry Oomen, Antonius Wiersma, Jacobijne J. Van Der Wal, Ruud M. A. Van Huysduynen-Monraats, Pascalle S. Hooft Karalis, Ioannis Verdel, Gerardus J. E. Brueren, Bart R. G. Troquay, Roland P. Th Viergever, Eric P. Al-Windy, Nadea Y. Y. Bartels, Gerard L. Ray, Kausik K. Cornel, Jan H. Hermans, Walter R. M. Herrman, Johannes P. R. Bos, Robert J. Groutars, Reginald G. E. J. Van Der Zwaan, Coenraad C. Kaplan, Refik Ronner, Eelko Groenemeijer, Bjorn E. Bronzwaer, Patrick N. A. Liem, Anho A. H. Rensing, Bernard J. W. M. Bokern, Marcel J. J. A. Nijmeijer, Remco Hersbach, Ferry M. R. J. Willems, Frank F. Gosselink, Antonius T. M. Elliott, John Wilkins, Gerard Fisher, Raewyn Vogel, Robert Scott, Douglas Hart, Hamish Stewart, Ralph Harding, Scott Ternouth, Ian Fisher, Nicholas Aitken, Denise Anscombe, Russell Tomala, Tadeusz Nygard, Ottar Chaitman, Bernard Sparby, Jon Arne Andersen, Kjell Gullestad, Lars Jortveit, Jarle Munk, Peter S. Hurtig, Ulf Ticona, Jorge R. Calderon Velasquez, Julio R. Durand Miguel, Sandra A. Negron Perez, Enrique S. Sanabria Kelsey, Sheryl F. Chambilla, Jesus M. Carrion Ayala, Carlos A. Chavez Leon, Reynaldo P. Castillo Gonzales, Rolando J. Vargas Zuniga, Jose D. Hernandez Cosavalente, Luis A. Camacho Mannucci, Jorge E. Bravo Navarro, Nassip C. Llerena Concha, Yudy M. Roldan Chavez, Victor E. Rodriguez Olsson, Anders G. Hernandez, Henry A. Anchante Nunez, Carlos A. Zea Ferrolino, Arthur Sy, Rosa Allyn G. Tirador, Louie Matiga, Generoso Coching, Raul Martin Bernan, Alisa Rogelio, Gregorio Morales, Dante D. Rouleau, Jean-Lucien Tan, Edgar Wlodarczak, Adrian Jaworska, Krystyna Skonieczny, Grzegorz Pawlowicz, Lidia Wojewoda, Pawel Busz-Papiez, Benita Bednarski, Janusz Goch, Aleksander Staneta, Pawel Simoons, Maarten L. Dulak, Elzbieta Saminski, Krzysztof Krasowski, Wlodzimierz Sudnik, Wanda Zurakowski, Aleksander Skorski, Marcin Lysek, Roman Miklaszewicz, Beata Kubica, Jacek Lipko, Jan Andrzej Alexander, Karen Kostarska-Srokosz, Edyta Piepiorka, Marek Drzewiecka, Anna Sciborski, Ryszard Stasiewski, Arkadiusz Blicharski, Tomasz Bystryk, Leszek Szpajer, Michal Korol, Marek Czerski, Tomasz Meloni, Chiara Mirek-Bryniarska, Ewa Gniot, Jacek Lubinski, Andrzej Gorny, Jerzy Franek, Edward Monteiro, Pedro Bastos, Jose Mesquita Pereira, Helder H. Martins, Dinis Seixo, Filipe Rosenson, Robert Mendonca, Carlos Botelho, Ana Minescu, Bogdan Istratoaie, Octavian Tesloianu, Dan N. Cristian, Gabriel Podoleanu, Cristian G. C. Constantinescu, Mircea C. A. Bengus, Cristina M. Militaru, Constantin Sijbrands, Eric J. G. Rosu, Doina Parepa, Irinel R. Matei, Adrian V. Alexandru, Tom M. Shvarts, Yury Orlikova, Olga Kobalava, Zhanna Barbarash, Olga L. Markov, Valentin Lyamina, Nadezhda Alexander, John H. Gordienko, Alexander Zrazhevsky, Konstantin Vishnevsky, Alexander Y. Gurevich, Victor Stryuk, Raisa Lomakin, Nikita V. Bokarev, Igor Shalaev, Sergey Khaisheva, Larisa Chizhov, Petr Armaganijan, Luciana Viktorova, Inna Osokina, Natalya Akatova, Evgenia Chumakova, Galina Libov, Igor Voevoda, Mikhail I. Tretyakova, Tatyana V. Baranov, Evgeny Shustov, Sergey Yakushin, Sergey Hanotin, Corinne Bagai, Akshay Gordeev, Ivan Khasanov, Niiaz Reshetko, Olga Sotnikova, Tatiana Molchanova, Olga Nikolaev, Konstantin Gapon, Liudmila Baranova, Elena Shogenov, Zaur Kosmachova, Elena Bahit, Maria Cecilia Karpov, Yuriy Povzun, Anton Egorova, Liudmila Tyrenko, Vadim V. Ivanov, Igor G. Simic, Dragan Ivanovic, Nikola Davidovic, Goran Tasic, Nebojsa Asanin, Milika R. Brennan, J. Matthew Stojic, Stevo Apostolovic, Svetlana R. Ilic, Stevan Putnikovic, Biljana Stankovic, Aleksandar Arandjelovic, Aleksandra Radovanovic, Slavica Balinovac, Jovan Dincic, Dragan V. Seferovic, Petar Clifton, Shaun Dodic, Slobodan Dimkovic, Sinisa Poh, Kian-Keong Ong, Hean Yee Micko, Karol Nociar, Jan Pella, Daniel Fulop, Peter Hranai, Marian Palka, Juraj DeVore, Adam D. Mazur, Juraj Majercak, Ivan Dzupina, Andrej Fazekas, Frantisek Gonsorcik, Jozef Bugan, Viliam Selecky, Juraj Kamensky, Gabriel Strbova, Jaroslava Smik, Rudolf Deloatch, Shalonda Dukat, Andrej Zuran, Ivan Oklukar, Janez Suligoj, Natasa Cernic Cevc, Matija Lipar, Luka Cyster, Henry P. Ranjith, Naresh Corbett, Clive Bayat, Junaid Dickey, Sheila Makotoko, Ellen Makoali Kapp, Ilse E. Basson, Matthys M. de V. Lottering, Hanlie Van Zyl, Louis J. Sebastian, Peter J. Pillay, Thayabran Saaiman, Jan A. Commerford, Patrick J. Cassimjee, Soraya Dombrowski, Keith Ebrahim, Iftikhar O. Sarvan, Mahomed Mynhardt, Joseph H. Reuter, Helmuth Moodley, Rajendran Vida, Manuel Cequier Fillat, Angel R. Bodi Peris, Vicente Fuentes Jimenez, Francisco Ducrocq, Gregory Marin, Francisco Cruz Fernandez, Jose M. Gil-Extremera, Blas Worner Diz, Fernando Garcia-Dorado, David Iniguez, Andres Tunon Fernandez, Jose Gonzalez-Juanatey, Jose R. Fernandez Portales, Javier Civeira Murillo, Fernando Eapen, Zubin Matas Pericas, Laia Luis Zamorano, Jose De Mora Martin, Manuel Bruguera Cortada, Jordi Alonso Martin, Joaquin J. De Berrazueta Fernandez, Jose R. Diaz Fernandez, Jose Francisco Garcia Lledo, Jose Alberto Cosin Sales, Juan Botas Rodriguez, Javier Sinnaeve, Peter İÜC Ege Üniversitesi Cardiology Internal Medicine ODYSSEY OUTCOMES Investigators
Source :
White, H D, Steg, P G, Szarek, M, Bhatt, D L, Bittner, V A, Diaz, R, Edelberg, J M, Erglis, A, Goodman, S G, Hanotin, C, Harrington, R A, Jukema, J W, Lopes, R D, Mahaffey, K W, Moryusef, A, Pordy, R, Roe, M T, Sritara, P, Tricoci, P, Zeiher, A M, Schwartz, G G, ODYSSEY OUTCOMES Committees and Investigators, Davidsen, F & Videbaek, L 2019, ' Effects of alirocumab on types of myocardial infarction : insights from the ODYSSEY OUTCOMES trial ', European Heart Journal, vol. 40, no. 33, pp. 2801-2809 . https://doi.org/10.1093/eurheartj/ehz299, European Heart Journal, 40(33), 2801-2809. OXFORD UNIV PRESS, European Heart Journal, Volume 40, Issue 33, European Heart Journal, 40(33), 2801-2809. Oxford University Press, European heart journal, EUROPEAN HEART JOURNAL, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, European heart journal 40(33), 2801-2809 (2019). doi:10.1093/eurheartj/ehz299 special issue: "Focus Issue on LIPIDS"
Publication Year :
2019
Publisher :
Uppsala universitet, Uppsala kliniska forskningscentrum (UCR), 2019.
Abstract
Gislason, Gunnar H/0000-0002-0548-402X; Malynovsky, Yaroslav V/0000-0002-9118-1104; Bhatt, Deepak L./0000-0002-1278-6245; Nikolaev, Konstantin/0000-0003-4601-6203; Sherwood, Matthew/0000-0002-4305-5883; Chumakova, Galina A/0000-0002-2810-6531; Raffel, Owen C/0000-0001-5470-7050; Leonardi, Sergio/0000-0002-4800-6132; Tse, Hung Fat/0000-0002-9578-7808; Reshetko, Olga/0000-0003-3107-7636; Pereira, Helder/0000-0001-8656-4883; Racca, Vittorio/0000-0002-4465-3789; Podoleanu, Cristian/0000-0001-9987-2519; Ersanli, Murat/0000-0003-1847-3087; Muenzel, Thomas/0000-0001-5503-4150; Sandhu, Manjinder/0000-0003-2538-2079; Taskinen, Marja-Riitta/0000-0002-6229-3588; bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Abbate, Antonio/0000-0002-1930-785X; STEG, Philippe Gabriel/0000-0001-6896-2941; Szarek, Michael/0000-0002-0046-0264; Bittner, Vera/0000-0001-9456-850X; Goodman, Shaun/0000-0001-8068-2440<br />WOS: 000490154300015<br />PubMed: 31121022<br />Aims the third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin-kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (>= 1.8 mmol/L) despite intensive statin therapy. in a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77-0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77-0.99; P = 0.032) and Type 2 (0.77, 0.61-0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. the data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.<br />Sanofi; Regeneron Pharmaceuticals<br />Supported by Sanofi and Regeneron Pharmaceuticals.
Details
Language :
English
ISSN :
0195668X and 15229645
Database :
OpenAIRE
Journal :
White, H D, Steg, P G, Szarek, M, Bhatt, D L, Bittner, V A, Diaz, R, Edelberg, J M, Erglis, A, Goodman, S G, Hanotin, C, Harrington, R A, Jukema, J W, Lopes, R D, Mahaffey, K W, Moryusef, A, Pordy, R, Roe, M T, Sritara, P, Tricoci, P, Zeiher, A M, Schwartz, G G, ODYSSEY OUTCOMES Committees and Investigators, Davidsen, F & Videbaek, L 2019, ' Effects of alirocumab on types of myocardial infarction : insights from the ODYSSEY OUTCOMES trial ', European Heart Journal, vol. 40, no. 33, pp. 2801-2809 . https://doi.org/10.1093/eurheartj/ehz299, European Heart Journal, 40(33), 2801-2809. OXFORD UNIV PRESS, European Heart Journal, Volume 40, Issue 33, European Heart Journal, 40(33), 2801-2809. Oxford University Press, European heart journal, EUROPEAN HEART JOURNAL, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, European heart journal 40(33), 2801-2809 (2019). doi:10.1093/eurheartj/ehz299 special issue: "Focus Issue on LIPIDS"
Accession number :
edsair.doi.dedup.....64ab629871b63c26bf509a1683855bb9