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The best--and most cost-effective--form of advertising is, and always will be, word of mouth. In the fitness industry, we stay in business over the long term because we get results [...]

The article discusses the advantages of online education for nonprofit executives who are in career transition or who are seeking graduate degrees. Online courses are preferred by students because they thrive online, they can create different settings, they can have better in-depth analysis and they are liberated from the constraints of the classroom. Also discussed are courses offered, colleges offering online courses, systems of interaction with other students and experiments with different online learning frameworks.

The article presents a 52-item food guide to restaurants, food, chefs, and food culture in the Minneapolis-S.t Paul, Minnesota region. It highlights pastry chef Michelle Gayer and the pastries at her Salty Tart bakery. It discusses Izzy's Ice Cream, which updates its ice cream availability every three minutes on its website. The article also showcases the bundt pan, which was invented in the area.

The article reports that the economic recession and cultural anxieties are driving a trend among students to go back to school to pursue higher studies. It states that the recession is driving students to pursue continuing education certificate programs and graduate courses in fundraising. The trend includes experienced fundraisers who want to raise confidence in soliciting donations. According to Marian Stern of the New York University's Heyman Center, studying fundraising prepares fundraisers for better economic times.

The article discusses popular food in Hong Kong, China, including the dishes Steamed Chicken with Golden Pins and Cloud Ears, Salted Egg Yolk Prawns and Steamed Minced Pork with Preserved White Cabbage.

The article discusses the BP Deepwater Horizon disaster six months after what is deemed as the worst man-made oil disaster in U.S. history. While the oil has stopped gushing into the Gulf of Mexico, more than a million barrels still linger just below the water's surface. A Gulf Coast Ecosystem Task Force was set up by President Barack Obama on October 5, 2010 to help Gulf residents restore healthy ecosystems in the surrounding areas. Federal Environmental Protection Agency Administrator Lisa P. Jackson's appointment as task force chair has been lauded.

The article focuses on the success of management training for nonprofit organizations in the U.S. in 2010. Ray Fisman, a professor and director of the Social Enterprise Program of Columbia Business School at Columbia University in New York, conducts proficient management training for both nonprofit and for-profit organizations. A nonprofit coursework is also offered at the Edward J. Bloustein School of Planning and Public Policy of Rutgers University in New Brunswick, New Jersey.

The article deals with the controversy surrounding the enlistment of model Naomi Campbell in the "Aid Rather Go Naked Than Wear Fur" campaign of the animal rights group People for the Ethical Treatment of Animals (PETA) in the 1990s. During the campaign, Campbell told reporters about her involvement in the anti-fur movement. But Campbell was seen modeling in the runway wearing designers' fur crations. PETA formally fired Campbell due to the incident.

Augmented renal clearance (ARC) is common in critically ill patients and is associated with subtherapeutic concentrations of renally eliminated antibiotics. We investigated the impact of ARC on bacterial killing and resistance amplification for meropenem and tobramycin regimens in monotherapy and combination. Two carbapenem-resistant Pseudomonas aeruginosaisolates were studied in static-concentration time-kill studies. One isolate was examined comprehensively in a 7-day hollow-fiber infection model (HFIM).

The poem "Twenty Years in the People's Republic of China" by Kate Rogers is presented. First Line: “There will be,” said my new boss, Last Line: Ribs poke through; the heart’s in shreds.

The poem "On My Way to Cantonese Class," by Kate Rogers is presented. First Line: I pass under century-old banyans; Last Line: to see who warns her.

The poem "Lamma Island Tofu-fa," by Kate Rogers is presented. First Line: On the broken trail to Mot tat; Last Line: bathed in the milk of the moon.

Hypermutable Pseudomonas aeruginosaorganisms are prevalent in chronic respiratory infections and have been associated with reduced lung function in cystic fibrosis (CF); these isolates can become resistant to all antibiotics in monotherapy. This study aimed to evaluate the time course of bacterial killing and resistance of meropenem and ciprofloxacin in combination against hypermutable and nonhypermutable P. aeruginosa.

ABSTRACTAugmented renal clearance (ARC) in critically ill patients can result in suboptimal drug exposures and treatment failure. Combination dosage regimens accounting for ARC have never been optimized and evaluated against Pseudomonas aeruginosaby use of the hollow-fiber infection model (HFIM). Using a P. aeruginosaisolate from a critically ill patient and static-concentration time-kill experiments (SCTKs), we studied clinically relevant piperacillin and tobramycin concentrations, alone and in combinations, against two inocula (105.8and 107.6CFU/ml) over 72 h. We subsequently evaluated the effects of optimized piperacillin (4 g every 4 h [q4h], given as 0.5-h infusions) plus tobramycin (5 mg/kg of body weight q24h, 7 mg/kg q24h, or 10 mg/kg q48h, given as 0.5-h infusions) regimens on killing and regrowth in the HFIM, simulating a creatinine clearance of 250 ml/min. Mechanism-based modeling was performed in S-ADAPT. In SCTKs, piperacillin plus tobramycin (except combinations with 8 mg/liter tobramycin and against the low inoculum) achieved synergistic killing (≥2 log10versus the most active monotherapy at 48 h and 72 h) and prevented regrowth. Piperacillin monotherapy (4 g q4h) in the HFIM provided 2.4-log10initial killing followed by regrowth at 24 h and resistance emergence. Tobramycin monotherapies displayed rapid initial killing (≥5 log10at 13 h) followed by extensive regrowth. As predicted by mechanism-based modeling, the piperacillin plus tobramycin dosage regimens were synergistic and provided ≥5-log10killing with resistance suppression over 8 days in the HFIM. Optimized piperacillin-tobramycin regimens provided significant bacterial killing and suppressed resistance emergence. These regimens appear to be highly promising for effective and early treatment, even in the near-worst-case scenario of ARC.

ABSTRACTHypermutable Pseudomonas aeruginosastrains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM). The PAO1 wild-type strain and its isogenic hypermutable PAOΔmutSstrain (MICmeropenemof 1.0 mg/liter and MICtobramycinof 0.5 mg/liter for both) were assessed using 96-h static-concentration time-kill studies (SCTK) and 10-day HFIM studies (inoculum, ∼108.4CFU/ml). MBM of SCTK data were performed to predict expected HFIM outcomes. Regimens studied in the HFIM were meropenem at 1 g every 8 h (0.5-h infusion), meropenem at 3 g/day with continuous infusion, tobramycin at 10 mg/kg of body weight every 24 h (1-h infusion), and both combinations. Meropenem regimens delivered the same total daily dose. Time courses of total and less susceptible populations and MICs were determined. For the PAOΔmutSstrain in the HFIM, all monotherapies resulted in rapid regrowth to >108.7CFU/ml with near-complete replacement by less susceptible bacteria by day 3. Meropenem every 8 h with tobramycin caused >7-log10bacterial killing followed by regrowth to >6 log10CFU/ml by day 5 and high-level resistance (MICmeropenem, 32 mg/liter; MICtobramycin, 8 mg/liter). Continuous infusion of meropenem with tobramycin achieved >8-log10bacterial killing without regrowth. For PAO1, meropenem monotherapies suppressed bacterial growth to <4 log10over 7 to 9 days, with both combination regimens achieving near eradication. An MBM-optimized meropenem plus tobramycin regimen achieved synergistic killing and resistance suppression against a difficult-to-treat hypermutable P. aeruginosastrain. For the combination to be maximally effective, it was critical to achieve the optimal shape of the concentration-time profile for meropenem.

ABSTRACTWe aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant Acinetobacter baumannii(CRAB) isolate (imipenem MIC, 32 mg/liter; tobramycin MIC, 2 mg/liter). Imipenem at constant concentrations (7.6, 13.4, and 23.3 mg/liter, reflecting a range of clearances) was simulated in a 7-day hollow-fiber infection model (inoculum, ∼107.2CFU/ml) with and without tobramycin (7 mg/kg q24h, 0.5-h infusions). While monotherapies achieved no killing or failed by 24 h, this rationally optimized combination achieved >5 log10bacterial killing and suppressed resistance.

The author focuses on issues related to coaching chamber music for middle-school students. She relates her first chamber music experience as a middle-school student, during which she and other students were asked by their viola teacher to play the piece "Eine Kleine Nachtmusik," composed by Wolfgang Amadeus Mozart. She also outlines some things she considers while conducting her own coaching sessions, one of which is to set long-term objectives and expectations at the very first meeting.

The article discusses the highlights of the 2010 National Conference on Volunteering and Service in New York City, New York. Leaders of various nonprofit firms met to evaluate the past decade's influence in their areas of service and their organizations' outlook for 2020. Nikki Cicerani of Upwardly Global talked about positive strides in immigration reform while Richard Buery of the Children's Aid Society fears a disconnect between communities will persist, aggravated by income inequality.

The article describes how two U.S. nonprofits, namely Washington, D.C.-based Defenders of Wildlife and New York City-based Covenant House, ran their campaigns to generate more funds from donors. Both nonprofits send direct mailings and renewals and then send certificates of acknowledgement to donors throughout the year. They also use other marketing strategies such as featuring fundraising messages on their websites, with Defenders also using its "Defenders" magazine.

The article discusses trends in religious donations in times of recession. It mentions that religious organizations kept communicating with their donors even if the giving is low and this resulted to almost equal total giving in 2008 and 2009 according to Giving USA. The article mentions that letting donors know that religious organizations understand the current economic situation can result in an overall positive impact on giving.

The article offers suggestions on how a nonprofit group can prevent itself from getting blacklisted by Internet service providers (ISP) for alleged spamming activities. Industry relations manager Andrew O'Halloran of Cypra Media recommends that an organization should indicate its reasons behind its intention of gathering the email address of a constituent. Idealware founder Laura Quinn advised nonprofit organizations to send periodic email to their donors and constituents in order to avoid being considered as a potential spam.

The article presents questions and answers related to donors of nonprofit organizations including why they are chosen to contribute to the organization, how much money should donors give an organization, and the urgency to contribute funds to the organization.

The article presents the reasons for the increase in demand for nonprofit programs in colleges and universities. The increase in demand for nonprofit programs started after the September 11, 2001 attack when citizens witnessed the response of the police and firefighters to the catastrophe. According to Roseanne Mirabella of Seton Hall University in New Jersey, the reasons for the increase includes recession, poor job market and displeasure with current careers.

The article provides an insight on the partnership between nonprofit and corporate organizations. According to Jay Aldous of Social Capital Strategic Partnerships, nonprofits should be selling impacts and not need and worthiness. John Egan of Coca-Cola Company said that charities can also be an asset, since nonprofits have a broader reach. Bryan McCleary of Procter & Gamble (P&G) relates that the partnership between P&G Pampers and UNICEF is an effective appeal to its target audience.

The poem "The Borrowed Children" by Kate Rogers is presented. First Line: My grief was asleep; Last Line: of the children I lost.

A response by Kate Rogers to a review of her poetry collection "Foreign Skin" is presented.

A response by Kate Rogers to a review of her poetry collection "Foreign Skin" is presented.

The article offers information concerning the cities of Minneapolis and Saint Paul in Minnesota. It reveals that Minneapolis and Saint Paul form the nation's 16th largest metropolitan area though separated by the Mississippi River. The article also reveals that Minnesota has more golfers per capital than any other state.