151. Myosteatosis predicts survival after surgery for periampullary cancer: a novel method using MRI.
- Author
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van Dijk, David P.J., Bakers, Frans C.H., Sanduleanu, Sebastian, Vaes, Rianne D.W., Rensen, Sander S., Dejong, Cornelis H.C., Beets-Tan, Regina G.H., and Olde Damink, Steven W.M.
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MAGNETIC resonance imaging , *CEREBROSPINAL fluid , *COMPUTED tomography , *MAGNETIC resonance , *ADIPOSE tissues - Abstract
Background Myosteatosis, characterized by inter- and intramyocellular fat deposition, is strongly related to poor overall survival after surgery for periampullary cancer. It is commonly assessed by calculating the muscle radiation attenuation on computed tomography (CT) scans. However, since magnetic resonance imaging (MRI) is replacing CT in routine diagnostic work-up, developing methods based on MRI is important. We developed a new method using MRI-muscle signal intensity to assess myosteatosis and compared it with CT-muscle radiation attenuation. Methods Patients were selected from a prospective cohort of 236 surgical patients with periampullary cancer. The MRI-muscle signal intensity and CT-muscle radiation attenuation were assessed at the level of the third lumbar vertebra and related to survival. Results Forty-seven patients were included in the study. Inter-observer variability for MRI assessment was low (R 2 = 0.94). MRI-muscle signal intensity was associated with short survival: median survival 9.8 (95%-CI: 1.5–18.1) vs. 18.2 (95%-CI: 10.7–25.8) months for high vs. low intensity, respectively (p = 0.038). Similar results were found for CT-muscle radiation attenuation (low vs. high radiation attenuation: 10.8 (95%-CI: 8.5–13.1) vs. 15.9 (95%-CI: 10.2–21.7) months, respectively; p = 0.046). MRI-signal intensity correlated negatively with CT-radiation attenuation ( r =−0.614, p < 0.001). Conclusions Myosteatosis may be adequately assessed using either MRI-muscle signal intensity or CT-muscle radiation attenuation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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