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Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP.
- Source :
-
Atherosclerosis [Atherosclerosis] 2018 Aug; Vol. 275, pp. 149-155. Date of Electronic Publication: 2018 Jun 07. - Publication Year :
- 2018
-
Abstract
- Background and Aims: We recently showed that plasma cholesteryl ester transfer protein (CETP) is mainly derived from VSIG4-positive Kupffer cells. Activation of these cells by the bacterial endotoxin lipopolysaccharide (LPS) strongly decreases CETP expression. As Kupffer cell activation plays a detrimental role in the progression of non-alcoholic fatty liver disease (NAFLD), we aimed to study if metabolic liver inflammation is also associated with a decrease in hepatic and circulating CETP.<br />Methods: We collected plasma and liver biopsy samples at various stages of NAFLD from 93 obese individuals who underwent bariatric surgery. Liver lobular inflammation was histologically determined, and liver CETP expression, CETP positive cells, circulating CETP concentrations, and liver VSIG4 expression were quantified.<br />Results: Mean (SD) plasma CETP concentration was 2.68 (0.89) μg/mL. In the presence of liver inflammation, compared to the absence of pathology, the difference in hepatic CETP expression was -0.03 arbitrary units (95% CI -0.26, 0.20), the difference in number of hepatic CETP positive cells (range 11-140 per mm <superscript>2</superscript> ) was -20.0 per mm <superscript>2</superscript> (95% CI -41.6, 1.9), and the difference in plasma CETP was -0.35 μg/mL (95% CI -0.80, 0.10). Hepatic VSIG4 expression was not associated with liver inflammation (0.00; 95% CI -0.15, 0.15).<br />Conclusions: We found no strong evidence for a strong negative association between metabolic liver inflammation and CETP-related outcomes in obese individuals, although we observed consistent trends. These data indicate that metabolic liver inflammation does not mimic the strong effects of LPS on the hepatic expression and production of CETP by Kupffer cells.<br /> (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Bariatric Surgery
Biomarkers blood
Biopsy
Cholesterol Ester Transfer Proteins genetics
Cross-Sectional Studies
Female
Hepatitis diagnosis
Hepatitis etiology
Humans
Kupffer Cells pathology
Liver pathology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease diagnosis
Non-alcoholic Fatty Liver Disease etiology
Obesity complications
Obesity diagnosis
Obesity surgery
Receptors, Complement genetics
Receptors, Complement metabolism
Cholesterol Ester Transfer Proteins blood
Hepatitis blood
Kupffer Cells metabolism
Liver metabolism
Non-alcoholic Fatty Liver Disease blood
Obesity blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 275
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 29902703
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2018.06.004