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160 results on '"Pierre Vanderzwalmen"'

154. Successful fertilization by testicular spermatozoa in an in-vitro fertilization programme

Author

Robert Schoysman, M. Nijs, G. Segal-Bertin, Pierre Vanderzwalmen, and M. van de Casseye

Subjects
In vitro fertilisation, business.industry, medicine.medical_treatment, Rehabilitation, Vas deferens, Obstetrics and Gynecology, medicine.disease, Male infertility, Andrology, Human fertilization, medicine.anatomical_structure, Reproductive Medicine, Medicine, business
Published
1993
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157. P-131. Synchronous development of embryos after prolonged culture in sequential media is a good predictor of therapy outcome in various age groups

Author

Nicolas H. Zech, Pierre Vanderzwalmen, M. Nijs, H. Zech, Astrid Stecher, Bernard Lejeune, and B. Vandamme

Subjects
Therapy Outcome, medicine.medical_specialty, Reproductive Medicine, Age groups, business.industry, Internal medicine, Rehabilitation, Obstetrics and Gynecology, Medicine, Embryo, business, Sequential media, Surgery
Published
1999
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158. Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer.

Author

Peter Schwärzler, Herbert Zech, Margherita Auer, Karin Pfau, Georg Göbel, Pierre Vanderzwalmen, and Nicolas Zech

Subjects
PREGNANCY, BLASTOCYST, EMBRYO transfer, HUMAN abnormalities
Abstract

BACKGROUND: Retrospective cohort study to evaluate differences in outcome when embryo transfer was performed either on day 2–3 (cleavage stage, CS-group) or on day 4–5 (blastocyst stage, BS-group). METHODS: A total of 1259 consecutive cycles yielding 500 live born babies performed at a single centre in Bregenz, Austria, were included. Main outcome measures were implantation and (multiple) pregnancy rates and neonatal outcome including birth defects. RESULTS: Total Pregnancy rate was 44% vs 28% (P<0.001) and the total ‘take home baby rate’ was 37% vs 22% in the BS-group and the CS-group, respectively. Rate of multiple gestations (34% vs 17%, P=0.001) was significantly higher among the BS-group, resulting in a higher rate of preterm deliveries <36 weeks (26% vs 17%, P=0.045). Female factor causing infertility (40% vs 21%, P<0.001) was significantly higher among the BS-group. For the CS-group, rate of singleton pregnancies (83% vs 66%, P=0.001) and idiopathic cause of infertility (34% vs 22%, P=0.012) were significantly higher. No statistically significant differences were found in sex, Caesarean section rate, Apgar score and umbilical artery pH-values, total mean birth weight, admission rate to intensive care unit, days of hospitalization and number of minor and major birth defects. CONCLUSIONS: Our data suggest that blastocyst transfer may lead to a higher pregnancy rate with an overall better take-home baby rate (THBR) at the cost of higher rates of multiples and preterm deliveries. [ABSTRACT FROM AUTHOR]

Published
2004
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160. Blastocyst development after sperm selection at high magnification is associated with size and number of nuclear vacuoles

Author

Sabine Vanderzwalmen, Paul Rubner, Anton Neyer, Magnus Bach, Antje Hiemer, Guy Cassuto, P Uher, Astrid Stecher, Martin Zintz, Nicolas H. Zech, Bernard Lejeune, and Pierre Vanderzwalmen

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Embryonic Development, Biology, Intracytoplasmic sperm injection, Andrology, Pregnancy, medicine, Humans, Blastocyst, Sperm Injections, Intracytoplasmic, reproductive and urinary physiology, Infertility, Male, Gynecology, Cell Nucleus, urogenital system, Embryogenesis, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Embryo, Oocyte, Embryo Transfer, Sperm, Spermatozoa, Embryo transfer, medicine.anatomical_structure, Reproductive Medicine, Vacuoles, Female, Embryo quality, Developmental Biology
Abstract

Spermatozoa selection at high magnification before intracytoplasmic sperm injection seems to be positively associated with pregnancy rates after day 3 embryo transfers. The aim was to demonstrate an association between the presence of vacuoles in sperm nuclei and the competence of embryos to develop to day 5. Grading of spermatozoa at x 6000-x 12,500 magnification: grade I, no vacuoles; grade II,or=2 small vacuoles; grade III,or=1 large vacuole; grade IV, large vacuoles with other abnormalities. The outcome of embryo development in a group of 25 patients after sibling oocyte injection with the four different grades of spermatozoa showed no significant difference in embryo quality up to day 3. However, the occurrence of blastocyst formation was 56.3 and 61.4% with grade I and II spermatozoa respectively, compared with 5.1% with grade III and 0% with grade IV respectively (P0.001). Spermatozoa selection at high magnification using Nomarski interference contrast is useful to identify more precisely the size and the number of nuclear vacuoles that greatly exert a negative effect on embryo development to the blastocyst stage. These observations confirm previous studies pointing to possible 'early and late paternal effects', both of which may have an impact on early embryonic development.

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