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1,878 results on '"Parikh, Chirag R."'

155. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR

Author

Raman, Jai, Jeevanandam, Valluvan, Akhter, Shahab, Devarajan, Prasad, Bennett, Michael, Ma, Qing, Griffiths, Rachel, Edelstein, Charles, Passik, Cary, Nagy, Judy, Swaminathan, Madhav, Chu, Michael, Goldbach, Martin, Guo, Lin Ruo, McKenzie, Neil, Myers, Mary Lee, Novick, Richard, Quantz, Mac, Schumann, Virginia, Webster, Laura, Zappitelli, Michael, Palijan, Ana, Dewar, Michael, Darr, Umer, Hashim, Sabet, Elefteriades, John, Geirsson, Arnar, Garwood, Susan, Kemp, Rowena, Butrymowicz, Isabel, Koyner, Jay L., Coca, Steven G., Thiessen-Philbrook, Heather, Patel, Uptal D., Shlipak, Michael G., Garg, Amit X., and Parikh, Chirag R.

Published
2015
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157. Tenofovir disoproxil fumarate initiation and changes in urinary biomarker concentrations among HIV-infected men and women

Author

Zhang, William R., Scherzer, Rebecca, Estrella, Michelle M., Ascher, Simon B., Muiru, Anthony, Jotwani, Vasantha, Grunfeld, Carl, Parikh, Chirag R., Gustafson, Deborah, Kassaye, Seble, Sharma, Anjali, Cohen, Mardge, Tien, Phyllis C., Ng, Derek K., Palella, Frank J., Jr., Witt, Mallory D., Ho, Ken, and Shlipak, Michael G.

Published
2019
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161. The Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists/American Society of Extracorporeal Technology Clinical Practice Guidelines for the Prevention of Adult Cardiac Surgery–Associated Acute Kidney Injury

Author

Brown, Jeremiah R., primary, Baker, Robert A., additional, Shore-Lesserson, Linda, additional, Fox, Amanda A., additional, Mongero, Linda B., additional, Lobdell, Kevin W., additional, LeMaire, Scott A., additional, De Somer, Filip M. J. J., additional, Wyler von Ballmoos, Moritz, additional, Barodka, Viachaslau, additional, Arora, Rakesh C., additional, Firestone, Scott, additional, Solomon, Richard, additional, Parikh, Chirag R., additional, Shann, Kenneth G., additional, and Hammon, John, additional

Published
2022
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163. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity

Author

Qian, Long, primary, Menez, Steven, additional, Hu, David, additional, Weinstein, Jason, additional, Melchinger, Hannah, additional, Thiessen-Philbrook, Heather, additional, Luciano, Randy L., additional, Turner, Jeffrey M., additional, Perazella, Mark A., additional, Corona Villalobos, Celia Pamela, additional, Shaw, Melissa M., additional, Wilson, F. Perry, additional, Parikh, Chirag R., additional, and Moledina, Dennis G., additional

Published
2022
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166. End-Stage Renal Disease Among HIV-Infected Adults in North America

Author

North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (leDEA), Abraham, Alison G., Althoff, Keri N., Jing, Yuezhou, Estrella, Michelle M., Kitahata, Mari M., Wester, C. William, Bosch, Ronald J., Crane, Heidi, Eron, Joseph, Gill, M. John, Horberg, Michael A., Justice, Amy C., Klein, Marina, Mayor, Angel M., Moore, Richard D., Palella, Frank J., Parikh, Chirag R., Silverberg, Michael J., Golub, Elizabeth T., Jacobson, Lisa P., Napravnik, Sonia, and Lucas, Gregory M.

Published
2015

167. Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial

Author

Garg, Amit X., Devereaux, P.J., Hill, Andrew, Sood, Manish, Aggarwal, Bharat, Dubois, Luc, Hiremath, Swapnil, Guzman, Randolph, Iyer, Vikram, James, Matthew, McArthur, Eric, Moist, Louise, Ouellet, George, Parikh, Chirag R., Schumann, Virginia, Sharan, Sumit, Thiessen-Philbrook, Heather, Tobe, Sheldon, Wald, Ron, Walsh, Michael, Weir, Matthew, and Pannu, Neesh

Subjects
Curcumin -- Health aspects, Aneurysmectomy -- Methods -- Patient outcomes, Abdominal aortic aneurysm -- Development and progression -- Care and treatment, Health
Abstract

BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 biomarkers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma W-terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein). RESULTS: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9). INTERPRETATION: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media. Trial registration: ClinicalTrials.gov, no. NCT01225094., Many modern medicines come from plants. (1,2) Turmeric, a plant in the ginger family that is native to South Asia, has been used for centuries as a spice and traditional [...]

Published
2018
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168. Biomarkers of kidney tubule injury and dysfunction and risk of incident hypertension in community-living individuals: results from the multi-ethnic study of atherosclerosis

Author

Malhotra, Rakesh, primary, Katz, Ronit, additional, Kimmel, Paul L, additional, Vasan, Ramachandran S, additional, Schelling, Jeffrey S, additional, Greenberg, Jason H, additional, Parikh, Chirag R, additional, Bonventre, Joseph V, additional, Al-Rousan, Tala, additional, Sarnak, Mark J, additional, Gutierrez, Orlando M, additional, Shlipak, Michael G, additional, and Ix, Joachim H, additional

Published
2022
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170. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis

Author

Melchinger, Hannah, primary, Calderon-Gutierrez, Frida, additional, Obeid, Wassim, additional, Xu, Leyuan, additional, Shaw, Melissa M., additional, Luciano, Randy L., additional, Kuperman, Michael, additional, Moeckel, Gilbert W., additional, Kashgarian, Michael, additional, Wilson, F. Perry, additional, Parikh, Chirag R., additional, and Moledina, Dennis G., additional

Published
2022
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175. Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

Author

Weisbord, Steven D., Gallagher, Martin, Jneid, Hani, Garcia, Santiago, Cass, Alan, Thwin, Soe-Soe, Conner, Todd A., Chertow, Glenn M., Bhatt, Deepak L., Shunk, Kendrick, Parikh, Chirag R., McFalls, Edward O., Brophy, Mary, Ferguson, Ryan, Wu, Hongsheng, Androsenko, Maria, Myles, John, Kaufman, James, and Palevsky, Paul M.

Published
2018
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176. Kidney functional reserve helps early detection of subclinical chronic kidney disease.

Author

Noel, Sanjeev and Parikh, Chirag R.

Subjects
*CHRONIC kidney failure, *KIDNEYS, *HIGH-protein diet, *KIDNEY diseases, *KIDNEY tubules
Abstract

The article discusses the importance of kidney functional reserve (KFR) in the early detection of subclinical chronic kidney disease (CKD). CKD affects a significant portion of the global population, particularly in low- to middle-income countries, and is a major risk factor for end-stage renal disease and cardiovascular disease. Current biomarkers for CKD, such as serum creatinine and estimated glomerular filtration rate, are inefficient in detecting early-stage CKD. The study by Taylor et al. demonstrates that a reduction in KFR can detect subclinical CKD that is otherwise undetectable using traditional biomarkers. This finding has significant diagnostic and translational value and can guide early intervention to prevent the progression of CKD. [Extracted from the article]

Published
2023
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182. A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project

Author

Butler, Catherine R., primary, Appelbaum, Paul S., additional, Ascani, Heather, additional, Aulisio, Mark, additional, Campbell, Catherine E., additional, de Boer, Ian H., additional, Dighe, Ashveena L., additional, Hall, Daniel E., additional, Himmelfarb, Jonathan, additional, Knight, Richard, additional, Mehl, Karla, additional, Murugan, Raghavan, additional, Rosas, Sylvia E., additional, Sedor, John R., additional, O’Toole, John F., additional, Tuttle, Katherine R., additional, Waikar, Sushrut S., additional, Freeman, Michael, additional, Alexandrov, Theodore, additional, Alpers, Charles E., additional, Anderton, Christopher R., additional, Ardayfio, Joseph, additional, Arora, Tanima, additional, El-Achkar, Tarek M., additional, Azeloglu, Evren U., additional, Balderes, Olivia, additional, Balis, Ulysses G.J., additional, Bansal, Shweta, additional, Barasch, Jonathan M., additional, Barwinska, Daria, additional, Bebiak, Jack, additional, Blanc, Victoria M., additional, Blank, Kristina N., additional, Bomback, Andrew S., additional, Brown, Keith D., additional, Bush, William S., additional, Campbell, Taneisha, additional, Canetta, Pietro A., additional, Carson, Jonas, additional, Cooperman, Leslie, additional, Crawford, Dana C., additional, D’Agati, Vivette D., additional, Dagher, Pierre C., additional, Daniel, Stephen, additional, Dowd, Frederick, additional, Dunn, Kenneth W., additional, Eadon, Michael T., additional, Eddy, Sean, additional, Elder, Michele M., additional, Ferkowicz, Michael J., additional, Gaut, Joe P., additional, Goltsev, Yury, additional, Gonzalez-Vicente, Agustin, additional, Hacohen, Nir, additional, Hansen, Jens, additional, Hayashi, Lynda, additional, He, Oliver, additional, He, Cijang, additional, Hedayati, S. Susan, additional, Herlitz, Leal, additional, Hodgin, Jeffrey B., additional, Hoofnagle, Andrew N., additional, Hoover, Paul J., additional, Iyengar, Ravi, additional, Jain, Sanjay, additional, Jefferson, Nichole, additional, Jolly, Stacey, additional, Kellum, John A., additional, Kelly, Katherine J., additional, Kermani, Asra, additional, Kiryluk, Krzysztof, additional, Koewler, Robert, additional, Kretzler, Matthias, additional, Lake, Blue B., additional, Laszik, Zoltan G., additional, Lecker, Stewart H., additional, Lee, Simon C., additional, Lienczewski, Chrysta, additional, Lu, Christopher Y., additional, Mariani, Laura H., additional, McClelland, Robyn L., additional, McMahon, Gearoid M., additional, Menez, Steven, additional, Menon, Rajasree, additional, Miller, Tyler, additional, Moe, Orson W., additional, Moledina, Dennis, additional, Mooney, Sean D., additional, Nguyen, Jane, additional, Nolan, Garry, additional, Oliver, George, additional, Otto, Edgar, additional, Palevsky, Paul M., additional, Palmer, Ellen, additional, Pamreddy, Annapurna, additional, Parikh, Chirag R., additional, Parikh, Samir, additional, Park, Christopher, additional, Park, Harold, additional, Pasa-Tolic, Ljiljana, additional, Pinkeney, Roy, additional, Poggio, Emilio, additional, Randhawa, Parmjeet, additional, Rennke, Helmut, additional, Roberts, Glenda V., additional, Rosenberg, Avi, additional, Rosengart, Matthew, additional, Rovin, Brad, additional, Roy, Neil, additional, Sambandam, Kamalanathan, additional, Sarwal, Minnie, additional, Saul, John, additional, Schaub, Jennifer, additional, Sealfon, Rachel, additional, Shang, Ning, additional, Shankland, Stuart, additional, Sharma, Kumar, additional, Shpigel, Anna, additional, Sigdel, Tara, additional, Steck, Becky, additional, Stillman, Isaac, additional, Stutzke, Edith Christine, additional, Sutton, Timothy A., additional, Torrealba, Jose, additional, Toto, Robert D., additional, Troyanskaya, Olga, additional, Tublin, Mitchell, additional, Ugwuowo, Ugochukwu, additional, Vazquez, Miguel, additional, Velickovic, Dusan, additional, Venkatachalam, Manjeri, additional, Vijayan, Anitha, additional, Corona-Villalobos, Celia P., additional, Wang, Nancy, additional, Weins, Astrid, additional, Wilcox, Adam, additional, Williams, Kayleen, additional, Williams, Mark, additional, Wilson, Francis P., additional, Winfree, Seth, additional, Xiong, Yuguang, additional, Zhang, Kun, additional, and Zhang, Guanshi, additional

Published
2022
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183. The Evaluation of Coffee Therapy for Improvement of Renal Oxygenation (COFFEE) Study: A Mechanistic Pilot and Feasibility Study Evaluating Coffee’s Effects on Intrarenal Hemodynamic Function and Renal Energetics

Author

Tommerdahl, Kalie L., primary, Vinovskis, Carissa, additional, Li, Lu-Ping, additional, Rebholz, Casey M., additional, Severn, Cameron, additional, Hu, Emily A., additional, Selvin, Elizabeth, additional, Coresh, Josef, additional, Grams, Morgan E., additional, Prasad, Pottumarthi, additional, Parikh, Chirag R., additional, and Bjornstad, Petter, additional

Published
2022
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184. Associations of Plasma Biomarkers of Inflammation, Fibrosis, and Kidney Tubular Injury With Progression of Diabetic Kidney Disease: A Cohort Study

Author

Gutiérrez, Orlando M., primary, Shlipak, Michael G., additional, Katz, Ronit, additional, Waikar, Sushrut S., additional, Greenberg, Jason H., additional, Schrauben, Sarah J., additional, Coca, Steven, additional, Parikh, Chirag R., additional, Vasan, Ramachandran S., additional, Feldman, Harold I., additional, Kimmel, Paul L., additional, Cushman, Mary, additional, Bonventre, Joseph V., additional, Sarnak, Mark J., additional, and Ix, Joachim H., additional

Published
2022
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185. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Author

Menon, Rajasree, primary, Bomback, Andrew S., additional, Lake, Blue B., additional, Stutzke, Christy, additional, Grewenow, Stephanie M., additional, Menez, Steven, additional, D’Agati, Vivette D., additional, Jain, Sanjay, additional, Knight, Richard, additional, Lecker, Stewart H., additional, Stillman, Isaac, additional, Bogen, Steve, additional, Beck, Laurence H., additional, Waikar, Sushrut, additional, McMahon, Gearoid M., additional, Weins, Astrid, additional, Colona, Mia R., additional, Hacohen, Nir, additional, Hoover, Paul J., additional, Aulisio, Mark, additional, Bush, William S., additional, Crawford, Dana C., additional, O'toole, John, additional, Poggio, Emilio, additional, Sedor, John, additional, Cooperman, Leslie, additional, Jolly, Stacey, additional, Herlitz, Leal, additional, Nguyen, Jane, additional, Gonzalez-Vicente, Agustin, additional, Palmer, Ellen, additional, Sendrey, Dianna, additional, Vinovskis, Carissa, additional, Bjornstad, Petter M., additional, Appelbaum, Paul, additional, Barasch, Jonathan M., additional, D'Agati, Vivette D., additional, Kiryluk, Krzysztof, additional, Mehl, Karla, additional, Canetta, Pietro A., additional, Shang, Ning, additional, Balderes, Olivia, additional, Kudose, Satoru, additional, Bansal, Shweta, additional, Alexandrov, Theodore, additional, Rennke, Helmut, additional, El-Achkar, Tarek M., additional, Cheng, Yinghua, additional, Dagher, Pierre C., additional, Eadon, Michael T., additional, Dunn, Kenneth W., additional, Kelly, Katherine J., additional, Sutton, Timothy A., additional, Barwinska, Daria, additional, Ferkowicz, Michael J., additional, Winfree, Seth, additional, Bledsoe, Sharon, additional, Rivera, Marcelino, additional, Williams, James C., additional, Ferreira, Ricardo Melo, additional, Parikh, Chirag R., additional, Corona-Villalobos, Celia P., additional, Rosenberg, Avi, additional, Rosas, Sylvia E., additional, Roy, Neil, additional, Williams, Mark, additional, Azeloglu, Evren U., additional, He, Cijang, additional, Iyengar, Ravi, additional, Hansen, Jens, additional, Xiong, Yuguang, additional, Rovin, Brad, additional, Parikh, Samir, additional, Shapiro, John P., additional, Anderton, Christopher R., additional, Pasa-Tolic, Ljiljana, additional, Velickovic, Dusan, additional, Lukowski, Jessica, additional, Oliver, George, additional, Ardayfio, Joseph, additional, Bebiak, Jack, additional, Brown, Keith, additional, Campbell, Catherine E., additional, Saul, John, additional, Shpigel, Anna, additional, Koewler, Robert, additional, Campbell, Taneisha, additional, Hayashi, Lynda, additional, Jefferson, Nichole, additional, Roberts, Glenda V., additional, Pinkeney, Roy, additional, Troyanskaya, Olga, additional, Sealfon, Rachel, additional, Tuttle, Katherine R., additional, Goltsev, Yury, additional, Zhang, Kun, additional, Laszik, Zoltan G., additional, Nolan, Garry, additional, Boada, Patrick, additional, Sarwal, Minnie, additional, Sigdel, Tara, additional, Lee, Paul J., additional, Alloway, Rita R., additional, Woodle, E. Steve, additional, Ascani, Heather, additional, Balis, Ulysses G.J., additional, Hodgin, Jeffrey B., additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Mariani, Laura H., additional, Menon, Rajasree, additional, Steck, Becky, additional, He, Yougqun, additional, Otto, Edgar, additional, Schaub, Jennifer, additional, Blanc, Victoria M., additional, Eddy, Sean, additional, Conser, Ninive C., additional, Luo, Jinghui, additional, Palevsky, Paul M., additional, Rosengart, Matthew, additional, Kellum, John A., additional, Hall, Daniel E., additional, Randhawa, Parmjeet, additional, Tublin, Mitchell, additional, Murugan, Raghavan, additional, Elder, Michele M., additional, Winters, James, additional, Alpers, Charles E., additional, Blank, Kristina N., additional, Carson, Jonas, additional, De Boer, Ian H., additional, Dighe, Ashveena L., additional, Himmelfarb, Jonathan, additional, Mooney, Sean D., additional, Shankland, Stuart, additional, Williams, Kayleen, additional, Park, Christopher, additional, Dowd, Frederick, additional, McClelland, Robyn L., additional, Daniel, Stephen, additional, Hoofnagle, Andrew N., additional, Wilcox, Adam, additional, Sharma, Kumar, additional, Venkatachalam, Manjeri, additional, Zhang, Guanshi, additional, Pamreddy, Annapurna, additional, Ye, Hongping, additional, Montellano, Richard, additional, Toto, Robert D., additional, Vazquez, Miguel, additional, Lee, Simon C., additional, Miller, R. Tyler, additional, Moe, Orson W., additional, Torrealba, Jose, additional, Wang, Nancy, additional, Kermani, Asra, additional, Sambandam, Kamalanathan, additional, Park, Harold, additional, Hedayati, S. Susan, additional, Lu, Christopher Y., additional, Vijayan, Anitha, additional, Gaut, Joseph P., additional, Moledina, Dennis, additional, Wilson, Francis P., additional, Ugwuowo, Ugochukwu, additional, and Arora, Tanima, additional

Published
2022
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186. Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D

Author

Chen, Teresa K., primary, Coca, Steven G., additional, Estrella, Michelle M., additional, Appel, Lawrence J., additional, Coresh, Josef, additional, Thiessen Philbrook, Heather, additional, Obeid, Wassim, additional, Fried, Linda F., additional, Heerspink, Hiddo J.L., additional, Ix, Joachim H., additional, Shlipak, Michael G., additional, Kimmel, Paul L., additional, Parikh, Chirag R., additional, and Grams, Morgan E., additional

Published
2022
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190. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Author

Knight, Richard, Lecker, Stewart H., Stillman, Isaac, Bogen, Steve, Beck, Laurence H., Waikar, Sushrut, McMahon, Gearoid M., Weins, Astrid, Colona, Mia R., Hacohen, Nir, Hoover, Paul J., Aulisio, Mark, Bush, William S., Crawford, Dana C., O'toole, John, Poggio, Emilio, Sedor, John, Cooperman, Leslie, Jolly, Stacey, Herlitz, Leal, Nguyen, Jane, Gonzalez-Vicente, Agustin, Palmer, Ellen, Sendrey, Dianna, Vinovskis, Carissa, Bjornstad, Petter M., Appelbaum, Paul, Barasch, Jonathan M., Bomback, Andrew S., D'Agati, Vivette D., Kiryluk, Krzysztof, Mehl, Karla, Canetta, Pietro A., Shang, Ning, Balderes, Olivia, Kudose, Satoru, Bansal, Shweta, Alexandrov, Theodore, Rennke, Helmut, El-Achkar, Tarek M., Cheng, Yinghua, Dagher, Pierre C., Eadon, Michael T., Dunn, Kenneth W., Kelly, Katherine J., Sutton, Timothy A., Barwinska, Daria, Ferkowicz, Michael J., Winfree, Seth, Bledsoe, Sharon, Rivera, Marcelino, Williams, James C., Jr., Ferreira, Ricardo Melo, Parikh, Chirag R., Corona-Villalobos, Celia P., Menez, Steven, Rosenberg, Avi, Rosas, Sylvia E., Roy, Neil, Williams, Mark, Azeloglu, Evren U., He, Cijang, Iyengar, Ravi, Hansen, Jens, Xiong, Yuguang, Rovin, Brad, Parikh, Samir, Shapiro, John P., Anderton, Christopher R., Pasa-Tolic, Ljiljana, Velickovic, Dusan, Lukowski, Jessica, Oliver, George, Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Catherine E., Saul, John, Shpigel, Anna, Stutzke, Christy, Koewler, Robert, Campbell, Taneisha, Hayashi, Lynda, Jefferson, Nichole, Roberts, Glenda V., Pinkeney, Roy, Troyanskaya, Olga, Sealfon, Rachel, Tuttle, Katherine R., Goltsev, Yury, Zhang, Kun, Lake, Blue B., Laszik, Zoltan G., Nolan, Garry, Boada, Patrick, Sarwal, Minnie, Sigdel, Tara, Lee, Paul J., Alloway, Rita R., Woodle, E. Steve, Ascani, Heather, Balis, Ulysses G.J., Hodgin, Jeffrey B., Kretzler, Matthias, Lienczewski, Chrysta, Mariani, Laura H., Menon, Rajasree, Steck, Becky, He, Yougqun, Otto, Edgar, Schaub, Jennifer, Blanc, Victoria M., Eddy, Sean, Conser, Ninive C., Luo, Jinghui, Palevsky, Paul M., Rosengart, Matthew, Kellum, John A., Hall, Daniel E., Randhawa, Parmjeet, Tublin, Mitchell, Murugan, Raghavan, Elder, Michele M., Winters, James, Alpers, Charles E., Blank, Kristina N., Carson, Jonas, De Boer, Ian H., Dighe, Ashveena L., Himmelfarb, Jonathan, Mooney, Sean D., Shankland, Stuart, Williams, Kayleen, Park, Christopher, Dowd, Frederick, McClelland, Robyn L., Daniel, Stephen, Hoofnagle, Andrew N., Wilcox, Adam, Grewenow, Stephanie M., Sharma, Kumar, Venkatachalam, Manjeri, Zhang, Guanshi, Pamreddy, Annapurna, Ye, Hongping, Montellano, Richard, Toto, Robert D., Vazquez, Miguel, Lee, Simon C., Miller, R. Tyler, Moe, Orson W., Torrealba, Jose, Wang, Nancy, Kermani, Asra, Sambandam, Kamalanathan, Park, Harold, Hedayati, S. Susan, Lu, Christopher Y., Jain, Sanjay, Vijayan, Anitha, Gaut, Joseph P., Moledina, Dennis, Wilson, Francis P., Ugwuowo, Ugochukwu, Arora, Tanima, and D’Agati, Vivette D.

Published
2022
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191. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States

Author

Molnar, Miklos Z., Bhalla, Anshul, Azhar, Ambreen, Tsujita, Makoto, Talwar, Manish, Balaraman, Vasanthi, Sodhi, Amik, Kadaria, Dipen, Eason, James D., Hayek, Salim S., Coca, Steven G., Shaefi, Shahzad, Neyra, Javier A., Gupta, Shruti, Leaf, David E., Kovesdy, Csaba P., Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy‐Duyen, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean‐Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M, Cohen, Zaza, Allusson, Valerie, Bambrick‐Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Lisk, Rebecca, Zhou, Amy M., Kim, Ethan C., Chan, Lili, Mathews, Kusum S., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona‐Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Thakkar, Jyotsana, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez‐Mulett, Sergio L., Gomez‐Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander, Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price‐Haywood, Eboni G., Matute‐Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB, Avasare, Rupali S., Zonies, David, Leaf, David E, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu‐Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani‐Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy‐Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Arif, Ali, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz‐Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V, Ali, Muhammad Imran, Peters, Terri, Hughes, Kathy, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Douin, David J., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth‐Manikowski, Stephanie M., Joo, Min J., Lash, James P., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, Zerda, David De La, Fornoni, Alessia, Gershengorn, Hayley B., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, Hayer, Patrick O’, Meloche, Chelsea, Feroze, Rafey, Kishan J. Padalia, Bitar, Abbas, Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg‐Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Weiner, Daniel E., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, and Ugwuowo, Ugochukwu

Subjects
Male, medicine.medical_specialty, Critical Illness, medicine.medical_treatment, Comorbidity, 030230 surgery, Organ transplantation, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Intensive care, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Hospital Mortality, Renal replacement therapy, Pandemics, Survival rate, Aged, Transplantation, SARS-CoV-2, business.industry, Acute kidney injury, COVID-19, Original Articles, Organ Transplantation, Middle Aged, medicine.disease, United States, Hospitalization, Survival Rate, Intensive Care Units, Relative risk, Propensity score matching, Original Article, Female, business, Follow-Up Studies, Cohort study
Abstract

National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. From 4153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non-SOT patients. We used a binomial generalized linear model (log-binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non-SOT patients (40% and 43%, respectively; relative risk [RR] 0.92; 95% confidence interval [CI]: 0.70-1.22). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. 27%; RR [95% CI]: 1.34 [0.97-1.85]). Death and organ support requirement were similar between SOT and non-SOT critically ill patients with COVID-19.

Published
2020

192. Clinically adjudicated deceased donor acute kidney injury and graft outcomes

Author

Mansour, Sherry G, Khoury, Nadeen, Kodali, Ravi, Virmani, Sarthak, Reese, Peter P, Hall, Isaac E, Jia, Yaqi, Yamamoto, Yu, Thiessen-Philbrook, Heather R, Obeid, Wassim, Doshi, Mona D, Akalin, Enver, Bromberg, Jonathan S, Harhay, Meera N, Mohan, Sumit, Muthukumar, Thangamani, Singh, Pooja, Weng, Francis L, Moledina, Dennis G, Greenberg, Jason H, Wilson, Francis P, Parikh, Chirag R, Mansour, Sherry G, Khoury, Nadeen, Kodali, Ravi, Virmani, Sarthak, Reese, Peter P, Hall, Isaac E, Jia, Yaqi, Yamamoto, Yu, Thiessen-Philbrook, Heather R, Obeid, Wassim, Doshi, Mona D, Akalin, Enver, Bromberg, Jonathan S, Harhay, Meera N, Mohan, Sumit, Muthukumar, Thangamani, Singh, Pooja, Weng, Francis L, Moledina, Dennis G, Greenberg, Jason H, Wilson, Francis P, and Parikh, Chirag R

Abstract

Background: Acute kidney injury (AKI) in deceased donors is not associated with graft failure (GF). We hypothesize that hemodynamic AKI (hAKI) comprises the majority of donor AKI and may explain this lack of association. Methods: In this ancillary analysis of the Deceased Donor Study, 428 donors with available charts were selected to identify those with and without AKI. AKI cases were classified as hAKI, intrinsic (iAKI), or mixed (mAKI) based on majority adjudication by three nephrologists. We evaluated the associations between AKI phenotypes and delayed graft function (DGF), 1-year eGFR and GF. We also evaluated differences in urine biomarkers among AKI phenotypes. Results: Of the 291 (68%) donors with AKI, 106 (36%) were adjudicated as hAKI, 84 (29%) as iAKI and 101 (35%) as mAKI. Of the 856 potential kidneys, 669 were transplanted with 32% developing DGF and 5% experiencing GF. Median 1-year eGFR was 53 (IQR: 41-70) ml/min/1.73m2. Compared to non-AKI, donors with iAKI had higher odds DGF [aOR (95%CI); 4.83 (2.29, 10.22)] and had lower 1-year eGFR [adjusted B coefficient (95% CI): -11 (-19, -3) mL/min/1.73 m2]. hAKI and mAKI were not associated with DGF or 1-year eGFR. Rates of GF were not different among AKI phenotypes and non-AKI. Urine biomarkers such as NGAL, LFABP, MCP-1, YKL-40, cystatin-C and albumin were higher in iAKI. Conclusion: iAKI was associated with higher DGF and lower 1-year eGFR but not with GF. Clinically phenotyped donor AKI is biologically different based on biomarkers and may help inform decisions regarding organ utilization.

Published
2022

195. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury

Author

Zhao, Bixiao, Lu, Qiongshi, Cheng, Yuwei, Belcher, Justin M., Siew, Edward D., Leaf, David E., Body, Simon C., Fox, Amanda A., Waikar, Sushrut S., Collard, Charles D., Thiessen-Philbrook, Heather, Ikizler, Alp T., Ware, Lorraine B., Edelstein, Charles L., Garg, Amit X., Choi, Murim, Schaub, Jennifer A., Zhao, Hongyu, Lifton, Richard P., and Parikh, Chirag R.

Published
2017
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197. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

Author

Greenberg, Jason H., Whitlock, Richard, Zhang, William R., Thiessen-Philbrook, Heather R., Zappitelli, Michael, Devarajan, Prasad, Eikelboom, John, Kavsak, Peter A., Devereaux, P. J., Shortt, Colleen, Garg, Amit X., and Parikh, Chirag R.

Subjects
Cardiopulmonary bypass -- Research -- Complications and side effects, Interleukins -- Research -- Physiological aspects, Acute kidney failure -- Research -- Risk factors, Health
Abstract

Background Children undergoing cardiac surgery may exhibit a pronounced inflammatory response to cardiopulmonary bypass (CPB). Inflammation is recognized as an important pathophysiologic process leading to acute kidney injury (AKI). The aim of this study was to evaluate the association of the inflammatory cytokines interleukin (IL)-6 and IL-10 with AKI and other adverse outcomes in children after CPB surgery. Methods This is a sub-study of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) cohort, including 106 children ranging in age from 1 month to 18 years undergoing CPB. Plasma IL-6 and IL-10 concentrations were measured preoperatively and postoperatively [day 1 (within 6 h after surgery) and day 3]. Results Stage 2/3 AKI, defined by at least a doubling of the baseline serum creatinine concentration or dialysis, was diagnosed in 24 (23 %) patients. The preoperative IL-6 concentration was significantly higher in patients with stage 2/3 AKI [median 2.6 pg/mL, interquartile range (IQR) 2.6 0.6-4.9 pg/mL] than in those without stage 2/3 AKI (median 0.6 pg/mL, IQR 0.6-2.2 pg/mL) (p = 0.03). After adjustment for clinical and demographic variables, the highest preoperative IL-6 tertile was associated with a sixfold increased risk for stage 2/3 AKI compared with the lowest tertile (adjusted odds ratio 6.41, 95 % confidence interval 1.16-35.35). IL-6 and IL-10 levels increased significantly after surgery, peaking postoperatively on day 1. First postoperative IL-6 and IL-10 measurements did not significantly differ between patients with stage 2/3 AKI and those without stage 2/3 AKI. The elevated IL-6 level on day 3 was associated with longer hospital stay (p = 0.0001). Conclusions Preoperative plasma IL-6 concentration is associated with the development of stage 2/3 AKI and may be prognostic of resource utilization. Electronic supplementary material The online version of this article (doi:10.1007/s00467-015-3088-4) contains supplementary material, which is available to authorized users., Author(s): Jason H. Greenberg[sup.1] [sup.2] , Richard Whitlock[sup.6] , William R. Zhang[sup.2] , Heather R. Thiessen-Philbrook[sup.3] , Michael Zappitelli[sup.4] , Prasad Devarajan[sup.5] , John Eikelboom[sup.6] , Peter A. Kavsak[sup.7] , [...]

Published
2015
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200. A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk

Author

Williams, Stephen A., primary, Ostroff, Rachel, additional, Hinterberg, Michael A., additional, Coresh, Josef, additional, Ballantyne, Christie M., additional, Matsushita, Kunihiro, additional, Mueller, Christian E., additional, Walter, Joan, additional, Jonasson, Christian, additional, Holman, Rury R., additional, Shah, Svati H., additional, Sattar, Naveed, additional, Taylor, Roy, additional, Lean, Michael E., additional, Kato, Shintaro, additional, Shimokawa, Hiroaki, additional, Sakata, Yasuhiko, additional, Nochioka, Kotaro, additional, Parikh, Chirag R., additional, Coca, Steven G., additional, Omland, Torbjørn, additional, Chadwick, Jessica, additional, Astling, David, additional, Hagar, Yolanda, additional, Kureshi, Natasha, additional, Loupy, Kelsey, additional, Paterson, Clare, additional, Primus, Jeremy, additional, Simpson, Missy, additional, Trujillo, Nelson P., additional, and Ganz, Peter, additional

Published
2022
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