Kidney functional reserve helps early detection of subclinical chronic kidney disease.

The article discusses the importance of kidney functional reserve (KFR) in the early detection of subclinical chronic kidney disease (CKD). CKD affects a significant portion of the global population, particularly in low- to middle-income countries, and is a major risk factor for end-stage renal disease and cardiovascular disease. Current biomarkers for CKD, such as serum creatinine and estimated glomerular filtration rate, are inefficient in detecting early-stage CKD. The study by Taylor et al. demonstrates that a reduction in KFR can detect subclinical CKD that is otherwise undetectable using traditional biomarkers. This finding has significant diagnostic and translational value and can guide early intervention to prevent the progression of CKD. [Extracted from the article]