151. Photodynamic therapy of superficial basal cell carcinomas using topical 5-aminolevulinic acid in a nanocolloid lotion.
- Author
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Hürlimann AF, Hänggi G, and Panizzon RG
- Subjects
- Administration, Topical, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid administration & dosage, Biopsy, Carcinoma, Basal Cell pathology, Emulsions, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Photosensitizing Agents administration & dosage, Skin drug effects, Skin pathology, Skin Neoplasms pathology, Treatment Outcome, Aminolevulinic Acid therapeutic use, Carcinoma, Basal Cell drug therapy, Photochemotherapy, Photosensitizing Agents therapeutic use, Skin Neoplasms drug therapy
- Abstract
Background: Photodynamic therapy (PDT) of superficial basal cell carcinomas using endogenous protoporphyrin IX generated by topically applied 5-aminolevulinic acid (5-ALA) is an innovative and clinically encouraging approach., Objective: This paper reports on the first results of an ongoing clinical study on photodynamic therapy of 55 basal cell carcinomas in 19 patients., Methods: Because of the chemical instability of 5-ALA, a novel nanocolloid lotion was developed. This formulation was applied to the lesions under occlusive dressing 6 h before irradiation with visible light from an unfiltered halogen lamp. Light-induced fluorescence was used to ascertain the superficial extension of the tumors. The response to the therapy was assessed by visual inspection and in 13 patients also by biopsies., Results: After a single treatment, 47 (85%) basal cell carcinomas showed a complete response at a follow-up time of at least 6 months. For the remaining 8 (15%) lesions, a partial response was observed, indicated by a marked reduction of the tumor size. The treatment modality without local anesthetics was well tolerated by all patients, with only slight discomfort during light irradiation., Conclusion: Our results indicate that 5-ALA-PDT with our novel formulation, a nanocolloid lotion, is a highly effective and convenient therapy for the treatment of superficial basal cell carcinomas. Its use in the treatment of nodular tumors needs further investigations.
- Published
- 1998
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