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Photodynamic therapy of superficial basal cell carcinomas using topical 5-aminolevulinic acid in a nanocolloid lotion.
- Source :
-
Dermatology (Basel, Switzerland) [Dermatology] 1998; Vol. 197 (3), pp. 248-54. - Publication Year :
- 1998
-
Abstract
- Background: Photodynamic therapy (PDT) of superficial basal cell carcinomas using endogenous protoporphyrin IX generated by topically applied 5-aminolevulinic acid (5-ALA) is an innovative and clinically encouraging approach.<br />Objective: This paper reports on the first results of an ongoing clinical study on photodynamic therapy of 55 basal cell carcinomas in 19 patients.<br />Methods: Because of the chemical instability of 5-ALA, a novel nanocolloid lotion was developed. This formulation was applied to the lesions under occlusive dressing 6 h before irradiation with visible light from an unfiltered halogen lamp. Light-induced fluorescence was used to ascertain the superficial extension of the tumors. The response to the therapy was assessed by visual inspection and in 13 patients also by biopsies.<br />Results: After a single treatment, 47 (85%) basal cell carcinomas showed a complete response at a follow-up time of at least 6 months. For the remaining 8 (15%) lesions, a partial response was observed, indicated by a marked reduction of the tumor size. The treatment modality without local anesthetics was well tolerated by all patients, with only slight discomfort during light irradiation.<br />Conclusion: Our results indicate that 5-ALA-PDT with our novel formulation, a nanocolloid lotion, is a highly effective and convenient therapy for the treatment of superficial basal cell carcinomas. Its use in the treatment of nodular tumors needs further investigations.
- Subjects :
- Administration, Topical
Adult
Aged
Aged, 80 and over
Aminolevulinic Acid administration & dosage
Biopsy
Carcinoma, Basal Cell pathology
Emulsions
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Photosensitizing Agents administration & dosage
Skin drug effects
Skin pathology
Skin Neoplasms pathology
Treatment Outcome
Aminolevulinic Acid therapeutic use
Carcinoma, Basal Cell drug therapy
Photochemotherapy
Photosensitizing Agents therapeutic use
Skin Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1018-8665
- Volume :
- 197
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Dermatology (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 9812030
- Full Text :
- https://doi.org/10.1159/000018006