2,095 results on '"Obesity Hypoventilation Syndrome"'
Search Results
152. Patient -Ventilator Interaction in Chronic Respiratory Failure
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Royal Brompton & Harefield NHS Foundation Trust and Michelle Ramsay, Dr
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- 2014
153. Target Volume in Noninvasive Positive Pressure Ventilation (CIBLE)
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ResMed
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- 2014
154. Cost-effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial
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Patrick Brian Murphy, Maxime Patout, Gill Arbane, Swapna Mandal, Georgios Kaltsakas, Michael I Polkey, Mark Elliott, Jean-François Muir, Abdel Douiri, David Parkin, Jean-Paul Janssens, Jean Louis Pépin, Antoine Cuvelier, Clare Flach, Nicholas Hart, Guy's and St Thomas' Hospital [London], King‘s College London, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Royal Brompton and Harefield NHS Foundation Trust, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ADIR Association (ADIR), Office of Health Economics [London, UK] (OHE), Geneva University Hospital (HUG), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Rouen, Normandie Université (NU), and SALAS, Danielle
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[SDV] Life Sciences [q-bio] ,Pulmonary and Respiratory Medicine ,Inpatients ,Noninvasive Ventilation ,Cost-Benefit Analysis ,[SDV]Life Sciences [q-bio] ,Obesity Hypoventilation Syndrome ,Outpatients ,Quality of Life ,Humans ,Middle Aged ,Aged ,Non invasive ventilation - Abstract
BackgroundCurrent guidelines recommend that patients with obesity hypoventilation syndrome (OHS) are electively admitted for inpatient initiation of home non-invasive ventilation (NIV). We hypothesised that outpatient NIV setup would be more cost-effective.MethodsPatients with stable OHS referred to six participating European centres for home NIV setup were recruited to an open-labelled clinical trial. Patients were randomised via web-based system using stratification to inpatient setup, with standard fixed level NIV and titrated during an attended overnight respiratory study or outpatient setup using an autotitrating NIV device and a set protocol, including home oximetry. The primary outcome was cost-effectiveness at 3 months with daytime carbon dioxide (PaCO2) as a non-inferiority safety outcome; non-inferiority margin 0.5 kPa. Data were analysed on an intention-to-treat basis. Health-related quality of life (HRQL) was measured using EQ-5D-5L (5 level EQ-5D tool) and costs were converted using purchasing power parities to £(GBP).ResultsBetween May 2015 and March 2018, 82 patients were randomised. Age 59±14 years, body mass index 47±10 kg/m2and PaCO26.8±0.6 kPa. Safety analysis demonstrated no difference in ∆PaCO2(difference −0.27 kPa, 95% CI −0.70 to 0.17 kPa). Efficacy analysis showed similar total per-patient costs (inpatient £2962±£580, outpatient £3169±£525; difference £188.20, 95% CI −£61.61 to £438.01) and similar improvement in HRQL (EQ-5D-5L difference −0.006, 95% CI −0.05 to 0.04). There were no differences in secondary outcomes.DiscussionThere was no difference in medium-term cost-effectiveness, with similar clinical effectiveness, between outpatient and inpatient NIV setup. The home NIV setup strategy can be led by local resource demand and patient and clinician preference.Trial registration numbersNCT02342899andISRCTN51420481.
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- 2022
155. Søvnrelaterede respirationsforstyrrelser.
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PETRI, NIELS and BERG, SØREN
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Copyright of Tandlaegebladet is the property of Tandlaegeforeningen and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
156. Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS)
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Zhang Xilong, The First Affiliated Hospital of Nanjing Medical University
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- 2012
157. Echocardiographic Findings in Obesity Hypoventilation Syndrome
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Aylin Pıhtılı, Ekrem Karaayvaz, Züleyha Bingöl, Ahmet Kaya Bilge, Gülfer Okumuş, and Esen Kıyan
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Obesity Hypoventilation syndrome ,Obstructive Sleep Apnea syndrome ,pulmonary hypertension ,Medicine ,Medicine (General) ,R5-920 - Abstract
Objective: In Obesity Hypoventilation syndrome (OHS), pulmonary hypertension (PH) is an important morbidity and mortality reason compared to pure Obstructive Sleep Apnea syndrome (OSAS). However, few studies are available in the literature about this subject. For this reason, we evaluated OHS and pure OSAS cases in our study from the point of right heart-related echocardiographic parameters and PH. Materials and Methods: Obese [body mass index (BMI) >30 kg/m2] cases diagnosed by polysomnography were included in the study. The subjects were divided to two groups as OHS and pure OSAS. OHS criteria were defined as obesity (BMI >30 kg/m2) and for another reason unexplained (neuromuscular, chest wall, restrictive or obstructive pulmonary diseases) daytime hypercapnia (PaCO2 >45 mmHg). Patients with severe hypothyroidism, renal and heart insufficiency, cardiac drug anamnesis were not included in the study. Transthoracic echocardiography was performed to all cases and those with left-heart pathology were excluded from the study. Systolic pulmonary artery pressure (PABs) >35 mmHg was accepted as PH. Results: Of the 115 cases studied (mean age: 49.3±10.6/year, female/male: 53/62, BMI: 40.5±6.1 kg/m2), 70 were pure OSAS and 45 were OHS. In the OHS group, PABs, right ventricular diameter and pulmonary velocities were significantly higher than the pure OSAS group (p=0.002, p=0.015, p=0.012, respectively). The frequency of PH in OHS was significantly higher than group with pure OSAS (48.8% vs. 17.1%, p
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- 2017
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158. The Predictors of Obesity Hypoventilation Syndrome in Obstructive Sleep Apnea
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Aylin Pıhtılı, Züleyha Bingöl, and Esen Kıyan
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Apnea hypopnea index ,hypercapnia ,obesity ,obesity hypoventilation syndrome ,obstructive sleep apnea ,Medicine - Abstract
Background: As obesity increases, the frequency of obstructive sleep apnea and obesity hypoventilation syndrome increases also. However, obesity hypoventilation syndrome frequency is not known, as capnography and arterial blood gas analysis are not routinely performed in sleep laboratories. Aims: To investigate the frequency and predictors of obesity hypoventilation syndrome in obese subjects. Study Design: Retrospective clinical study Methods: Obese subjects who had arterial blood gas analysis admitted to the sleep laboratory and polysomnography were retrospectively analyzed. Subjects with restrictive (except obesity) and obstructive pulmonary pathologies were excluded. Demographics, Epworth-Sleepiness-Scale scores, polysomnographic data, arterial blood gas analysis, and spirometric measurements were recorded. Results: Of the 419 subjects, 45.1% had obesity hypoventilation syndrome. Apnea hypopnea index (p
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- 2017
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159. A case report of malignant obesity hypoventilation syndrome: A weighty problem in our ICUs
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Michael Tatusov, Joshua J. Joseph, and Brian M. Cuneo
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Morbid obesity ,Super obesity ,Obesity hypoventilation syndrome ,Multiple organ failure ,Malignant obesity hypoventilation syndrome ,Metabolic syndrome ,Diseases of the respiratory system ,RC705-779 - Abstract
Introduction: The obesity epidemic is reflected by increasing numbers of morbidly obese patients being admitted to intensive care units (ICUs). These are complicated patients whose care involves many diagnostic and treatment challenges. We are presenting a fatal case of super obesity, hypoventilation, and multi-organ failure known as malignant obesity hypoventilation syndrome (MOHS). Case presentation: 35 year old African American gentleman with a body mass index (BMI) of 115 kg/m2 presented to the hospital with respiratory distress. On admission he was noted to have multi-organ dysfunction including respiratory failure, renal failure, cardiac and liver abnormalities. His hospital course was remarkable for recurrent cardiac arrest following extubation, complicated tracheostomy, and progressive organ failure despite medical therapy. After a 30 day hospitalization, patient and family decided on terminal extubation owing to worsening medical condition and lack of therapeutic and disposition options. Discussion: The super obese present a number of challenges when admitted to the ICU. Patients with respiratory distress are frequently misdiagnosed and treated for asthma and COPD when obesity hypoventilation syndrome (OHS) is more consistent with the clinical picture. OHS in the superobese is often accompanied by multi-system organ dysfunction, a condition with high morbidity and mortality, with limited treatment options. Standard imaging techniques and procedures are made difficult or impossible by body habitus and often require expert intervention. Surgical options have been used in the treatment of the super obese and resulted in rapid weight loss, improvement in respiratory function, as well as improved metabolism and decreased inflammation. The role of surgery in MOHS remains to be elucidated. Conclusion: Physicians should be aware of MOHS as a common condition with high morbidity and mortality. Optimal management remains to be determined.
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- 2017
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160. Portuguese adaptation of the S3-non-invasive ventilation (S3-NIV) questionnaire for home mechanically ventilated patients
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Pedro Oliveira, C. P. Nogueira, S. Conde, Diva Ferreira, Wolfram Windisch, Rui Nunes, C. Ribeiro, Dan Adler, and Instituto de Saúde Pública da Universidade do Porto
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Male ,Quality of life ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Cronbach's alpha ,Surveys and Questionnaires ,medicine ,Humans ,Outpatient clinic ,Translations ,030212 general & internal medicine ,Side effects ,Aged ,Mechanical ventilation ,Obesity hypoventilation syndrome ,Noninvasive Ventilation ,Portugal ,Portuguese ,Questionnaire ,business.industry ,Explained variation ,medicine.disease ,Respiration, Artificial ,Exploratory factor analysis ,030228 respiratory system ,Home mechanical ventilation ,Physical therapy ,Breathing ,business - Abstract
Short, valid and easy to use tools are needed to monitor non-invasive ventilation in clinical practice and for organization of home mechanical ventilation services. The aim of this study was to develop a professional translation and cultural adaptation of the Portuguese S3 non-invasive ventilation questionnaire. 234 stable patients (128 male patients, 53.8%) with a mean age of 69.3 years under long-term home non-invasive ventilation were recruited from a single-center outpatient clinic. The most frequent diagnostic groups were obesity hypoventilation syndrome, chronic obstructive pulmonary disease and restrictive chest wall disorders. The Portuguese version of the questionnaire was obtained using translation back-translation process with two professional translators. Internal consistency for the total score was good (Cronbach’s α coefficient of 0.76) as well as for the “respiratory symptoms” and the “sleep and side effects” domains (Cronbach’s α coefficient = 0.68 and Cronbach’s α coefficient = 0.72, respectively). An exploratory factor analysis was performed leading to an explained variance of 54.6%, and resulted in 3 components. The Portuguese version of the S3-NIV questionnaire is a simple and valid tool for the routine clinical assessment of patients receiving home NIV.
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- 2022
161. Obesity hypoventilation syndrome in bariatric surgery patients: an underestimated disease
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Wenhui Chen, Jie Guo, Yalun Liang, Xiaotao Zhang, Shuwen Jiang, Ruixiang Hu, Wah Yang, Cunchuan Wang, and Zhiyong Dong
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Male ,Bicarbonates ,Cross-Sectional Studies ,Polysomnography ,Obesity Hypoventilation Syndrome ,Bariatric Surgery ,Humans ,Female ,Surgery ,Obesity ,Body Mass Index - Abstract
Obesity is a known risk factor for obesity hypoventilation syndrome (OHS). However, study on the prevalence and clinical characteristics of OHS among bariatric surgery patients is scarce.To investigate the prevalence of OHS in bariatric surgery patients and to identify its related predictors.The study was conducted at a bariatric surgery center in a tertiary university hospital.A cross sectional analysis was performed in the patients undergoing bariatric surgery between March 2017 and January 2020. Anthropometric, laboratory, pulmonary function, blood gas analysis, and polysomnographic data was collected and analyzed.Of 522 patients, the overall prevalence of OHS was 15.1%, with men (22.8 %) having a greater frequency than women (9.4%) (P.001). The prevalence increases with obesity severity, from 4.1% in those with body mass index (BMI)35 kg/mIn bariatric surgery patients, OHS presented a high prevalence, especially in men. Higher levels of BMI, neck circumference, serum bicarbonate, and CRP indicated higher risk of OHS.
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- 2022
162. Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive Ventilation (TeleMotiNIV)
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Miguel R. Goncalves, Clinical Professor
- Published
- 2012
163. Impact of treating obesity hypoventilation syndrome on body mass index.
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Andrade RGS, Masa JF, Borel JC, Drager LF, Genta PR, Mokhlesi B, and Lorenzi-Filho G
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Study Objectives: To evaluate the impact of positive airway pressure (PAP) therapy on body mass index (BMI) in patients with obesity hypoventilation syndrome (OHS) associated with obstructive sleep apnea (OSA)., Methods: A systematic review using the following terms: "obesity hypoventilation syndrome" AND "treatment" AND "randomized" using Cochrane Central Register of Controlled Trials, Medline and Web of Science was performed from the first data available until February 10, 2023. The inclusion criteria were: (1) original article; (2) adult OHS with concomitant OSA (apnea-hypopnea index or AHI ≥5 events/h); (3) randomized trial with PAP arm and standard care (control); (4) BMI evaluation at baseline and after the first months. We performed an individual participant data meta-analysis of randomized controlled trials., Results: Our initial search retrieved 32 articles and 3 randomized studies fulfilled study criteria and were included in the final analysis, leading to a total of 342 participants. Patients were predominantly females (62%) and had OHS associated with at least mild OSA. As compared to baseline, a decrease in BMI was observed at study endpoint but this difference was not different intergroups (-0.50 ± 1.49 and -0.50 ±1.83, in control and PAP groups respectively (p=0.939)). Weight change was not associate with PAP adherence, OSA severity or use of supplemental oxygen., Conclusions: In contrast to treatment of eucapnic OSA with PAP that is associated with weight gain, treatment of OSA+OHS patients with or without PAP is associated with weight loss. Future studies are necessary to elucidate the mechanism by which weight loss occurs., Competing Interests: Conflicts of interest No potential conflict of interest exists with any companies/organizations whose products or services may be discussed in this article., (Copyright © 2023 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2023
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164. Cardiopulmonary coupling and serum cardiac biomarkers in obesity hypoventilation syndrome and obstructive sleep apnea with morbid obesity
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Sheila Sivam, David Wang, Keith K.H. Wong, Amanda J. Piper, Yi Zhong Zheng, Gislaine Gauthier, Christine Hockings, Olivia McGuinness, Collette Menadue, Kerri Melehan, Sara Cooper, Hugi Hilmisson, Craig L. Phillips, Robert J. Thomas, Brendon J. Yee, and Ronald R. Grunstein
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Pulmonary and Respiratory Medicine ,Neurology ,Polysomnography ,Obesity Hypoventilation Syndrome ,Australia ,Humans ,Neurology (clinical) ,Scientific Investigations ,Biomarkers ,Obesity, Morbid - Abstract
STUDY OBJECTIVES: The main cause of death in patients with obesity hypoventilation syndrome (OHS) is cardiac rather than respiratory failure. Here, we investigated autonomic-respiratory coupling and serum cardiac biomarkers in patients with OHS and obstructive sleep apnea (OSA) with comparable body mass index and apnea-hypopnea index. METHODS: Cardiopulmonary coupling (CPC) and cyclic variation of heart rate analysis was performed on the electrocardiogram signal from the overnight polysomnogram. Cardiac serum biomarkers were obtained in patients with OHS and OSA with a body mass index > 40 kg/m(2). Samples were obtained at baseline and after 3 months of positive airway pressure (PAP) therapy in both groups. RESULTS: Patients with OHS (n = 15) and OSA (n = 36) were recruited. No group differences in CPC, cyclic variation of heart rate, and serum biomarkers were observed at baseline and after 3 months of PAP therapy. An improvement in several CPC metrics, including the sleep apnea index, unstable sleep (low-frequency coupling and elevated low-frequency coupling narrow band), and cyclic variation of heart rate were observed in both groups with PAP use. However, distinct differences in response characteristics were noted. Elevated low-frequency coupling narrow band coupling correlated with highly sensitive troponin-T (P
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- 2023
165. The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
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Spanish Respiratory Society and Neus Salord Oleo
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- 2009
166. Respiratory Diseases in Obesity
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Chapman, David G., Suratt, Benjamin T., Dixon, Anne E., Bendich, Adrianne, Series editor, Fantuzzi, Giamila, editor, and Braunschweig, Carol, editor
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- 2014
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167. Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome.
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Amra, Babak, Samadi, Behrooz, and Soltaninejad, Forogh
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BODY mass index , *BODY composition , *OVERWEIGHT persons , *HYPOVENTILATION , *PEARSON correlation (Statistics) - Abstract
Background: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS). Materials and Methods: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, were included. The peripheral capillary oxygen saturation (SPO2), partial pressure of carbon dioxide (PCO2), body mass index (BMI), and body composition indices, including total body fat (TBF), total body protein (TBP), total body mineral (TBM), and total body water (TBW), were measured using standard procedures at baseline and one week, one month, and six months after the onset of treatment. Changes in the variables over time were evaluated using repeated measures analysis of variance (ANOVA). The correlation between changes in the body composition indices and changes in gas exchange was also assessed by Pearson's correlation coefficient test at three time points from the baseline. Results: The results revealed that all study variables, except for TBF, changed significantly during the study in both males and females (P<0.001). There was a significant positive association between changes in PCO2 and changes in TBM after six months (r=0.4, P<0.05), whereas a significant inverse correlation was found between changes in PCO2 and changes in TBW after six months (r=-0.39, P<0.05). However, no significant correlation was found between changes in gas exchange and changes in BMI or other body composition indices after six months. Conclusion: The present results indicated no significant association between the improvement of gas exchange and changes in BMI, TBP, and TBF during the study. However, further large-scale studies are required to examine the effects of BIPAP therapy on body composition in patients with OHS. [ABSTRACT FROM AUTHOR]
- Published
- 2019
168. Non‐invasive ventilation for obese patients with chronic respiratory failure: Are two pressures always better than one?
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Murphy, Patrick B., Suh, Eui‐Sik, and Hart, Nicholas
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HYPOVENTILATION , *RESPIRATORY insufficiency , *NONINVASIVE ventilation , *OBSTRUCTIVE lung diseases , *SLEEP apnea syndromes , *QUALITY of life - Abstract
Obesity‐related respiratory failure is increasingly common but remains under‐diagnosed and under‐treated. There are several clinical phenotypes reported, including severe obstructive sleep apnoea (OSA), isolated nocturnal hypoventilation with or without severe OSA and OSA complicating chronic obstructive pulmonary disease (COPD). The presence of hypercapnic respiratory failure is associated with poor clinical outcomes in each of these groups. While weight loss is a core aim of management, this is often unachievable, and treatment of sleep‐disordered breathing with positive airway pressure (PAP) therapy is the mainstay of clinical practice. Although there are few long‐term clinical efficacy trials, the lack of equipoise would prevent the utilization of an untreated control group. The current data support the use of PAP therapy to improve respiratory failure and is associated with improvements in health‐related quality of life, reduced healthcare utilization and reduced mortality. Both continuous PAP (CPAP) and non‐invasive ventilation (NIV) appear safe and effective in patients with obesity‐related respiratory failure and OSA, with or without COPD, and the current evidence would not support a single therapy choice in all patients. There are no studies of CPAP in patients with isolated nocturnal hypoventilation, and NIV would be the current recommendation in this patient group. Whichever starting therapy is used, titration should be performed to correct sleep‐disordered breathing and reverse chronic respiratory failure, with consideration of step‐down of the treatment based on a clinical re‐evaluation. In contrast, failure to reach physiological and clinical treatment targets should lead to the consideration of treatment escalation. [ABSTRACT FROM AUTHOR]
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- 2019
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169. Outcome of Frail Do-Not-Intubate Subjects With End-Stage Chronic Respiratory Failure and Their Opinion of Noninvasive Ventilation to Reverse Hypercapnic Coma.
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Lemyze, Malcolm, De Palleja, Gaël, Guiot, Aurélie, Bury, Quentin, Jonard, Marie, Granier, Maxime, Thevenin, Didier, and Mallat, Jihad
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RESPIRATORY insufficiency treatment ,ARTIFICIAL respiration ,CHRONIC diseases ,COMA ,COMPARATIVE studies ,DO-not-resuscitate orders ,FRAIL elderly ,HYPERCAPNIA ,LONGITUDINAL method ,SCIENTIFIC observation ,QUALITY of life ,QUESTIONNAIRES ,RESPIRATORY insufficiency ,SURVEYS ,SURVIVAL ,TREATMENT effectiveness ,CONTINUING education units ,CASE-control method ,DESCRIPTIVE statistics ,HOSPITAL mortality ,TERTIARY care ,DISEASE complications - Abstract
BACKGROUND: The use of noninvasive ventilation (NIV) in the emergency setting to reverse hypercapnic coma in frail patients with end-stage chronic respiratory failure and do-not-intubate orders remains a questionable issue given the poor outcome of this vulnerable population. We aimed to answer this issue by assessing not only subjects' outcome with NIV but also subjects' point of view regarding NIV for this indication. METHODS: A prospective observational case-control study was conducted in 3 French tertiary care hospitals during a 2-y period. Forty-three individuals who were comatose (with pH < 7.25 and P
aCO2 > 100 mm Hg at admission) were compared with 43 subjects who were not comatose and who were treated with NIV for acute hypercapnic respiratory failure. NIV was applied by using the same protocol in both groups. They all had a do-notintubate order and were considered vulnerable individuals with end-stage chronic respiratory failure according to well-validated scores. RESULTS: NIV yielded similar outcomes in the 2 groups regarding in-hospital mortality (n = 12 [28%] vs n = 12 [28%] in the noncomatose controls, P > .99) and 6-month survival (n = 28 [65%] vs n = 22 [51%] in the noncomatose controls, P = .31). Despite poor quality of life scores (21.5 ± 10 vs 31 ± 6 in the awakened controls, P = .056) as assessed by using the VQ11 questionnaire 6 months to 1 y after hospital discharge, a large majority of the survivors (n = 23 [85%]) would be willing to receive NIV again if a new episode of acute hypercapnic respiratory failure occurs. CONCLUSIONS: In the frailest subjects with supposed end-stage chronic respiratory failure that justifies treatment limitation decisions, it is worth trying NIV when acute hypercapnic respiratory failure occurs, even in the case of extreme respiratory acidosis with hypercapnic coma at admission. [ABSTRACT FROM AUTHOR]- Published
- 2019
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170. Comparison between auto-trilevel and bilevel positive airway pressure ventilation for treatment of patients with concurrent obesity hypoventilation syndrome and obstructive sleep apnea syndrome.
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Zou, Chunfang, Sheng, Weiwei, Huai, De, Cao, Juan, Su, Mei, Ning, Ding, Xue, Rong, Wang, Yanli, Huang, Mao, and Zhang, Xilong
- Abstract
Purpose: Our study aims to compare the difference in clinical efficacy between auto-trilevel positive airway pressure (auto-trilevel PAP) ventilator and conventional fixed bilevel positive airway pressure (BiPAP) ventilator for obesity hypoventilation syndrome (OHS) patients with coexisting moderate or severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: Twenty-three OHS patients with moderate or severe OSAHS enrolled between January 2015 and September 2017 underwent ventilation by three different modes of positive airway pressure (PAP) for 8 h per night. A single variable mode was applied at the first night followed by two nights when no PAP therapy was carried out as a washout period between each mode. The inspiratory positive airway pressure (IPAP) decided by PaCO
2 was consistently used for modes 1, 2, and 3. In mode 1, the expiratory positive airway pressure (EPAP) issued by BiPAP was decided by the minimal PAP levels for cessation of snoring. However, in mode 2, the EPAP was fixed at 3 cmH2 O higher than this value. With the use of auto-trilevel PAP in mode 3, the EPAP was set to initially match that of mode 1 but the end of EPAP (EEPAP) was automatically regulated to be elevated according to upper airway patency condition. We also compared the following parameters including apnea hypopnea index (AHI), minimal SpO2 (miniSpO2 ), arousal index, and sleep efficiency during sleep; PaCO2 in the morning and Epword sleepiness score (ESS) at daytime were measured prior to and during PAP treatment as well as between three selected PAP modes. Results: Compared with the parameters before ventilation therapies, all three variable modes of ventilation were associated with a higher nocturnal miniSpO2 and sleep efficiency (all P < 0.01). Among the three variable modes, mode 3 resulted in not only the lowest arousal index and daytime ESS but also the highest sleep efficiency. Compared to mode 1, mode 2 demonstrated a significantly reduced AHI and an elevated miniSpO2 and morning PaCO2 (all P < 0.05), while mode 3 was associated with a decreased AHI, an increased miniSpO2 (all P < 0.05), and no statistical change of PaCO2 following the end of PAP treatment (P > 0.05). Comparison between mode 2 and mode 3 revealed that mode 3 had a significantly lower PaCO2 (P < 0.05), but displayed no remarkable changes of AHI and miniSpO2 (all P > 0.05). Conclusion: Compared to fixed BiPAP ventilation, auto-trilevel PAP ventilation could more effectively correct hypercapnia, achieve lower index of nocturnal apnea and hypopnea, more improved sleep quality, and lower daytime sleepiness score. Auto-trilevel PAP ventilation is therefore more efficacious than conventional BiPAP ventilation in non-invasive ventilation therapy for OHS patients with concurrent moderate or severe OSAHS. [ABSTRACT FROM AUTHOR]- Published
- 2019
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171. Obesity cardiomyopathy: the role of obstructive sleep apnea and obesity hypoventilation syndrome.
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Newmarch, William, Weiler, Madina, and Casserly, Brian
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The negative long-term health consequences of obesity are well known to both the medical profession and general public. Despite this, the number of obese and overweight individuals worldwide continues to steadily rise. Although obesity has long been associated with an increased risk for cardiovascular disease and mortality, the classification of a cardiomyopathy of obesity is a more recent development. Obesity cardiomyopathy is characterized as myocardial dysfunction or heart failure in obese individuals independent of other cardiovascular risk factors. The purpose of this report is to provide an overview of obesity cardiomyopathy and the proposed pathophysiological mechanisms underlying this disease, as well as to examine the link between obesity cardiomyopathy and sleep-related disorders. [ABSTRACT FROM AUTHOR]
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- 2019
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172. Comparison of arterial and venous blood gases in patients with obesity hypoventilation syndrome and neuromuscular disease.
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Orucova, Hicran, Cagatay, Tulin, Bingol, Zuleyha, Cagatay, Penbe, Okumus, Gulfer, and Kiyan, Esen
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OBESITY complications , *ARTERIES , *BLOOD gases analysis , *STATISTICAL correlation , *NEUROMUSCULAR diseases , *PICKWICKIAN syndrome , *VEINS - Abstract
OBJECTIVES: Obesity hypoventilation syndrome (OHS) and some neuromuscular diseases (NMD) present with hypercapnic respiratory failure. Arterial blood gas (ABG) analysis is important in the diagnosis, follow-up, and treatment response of these diseases. However, ABG sampling is difficult in these patients because of excessive subcutaneous fat tissue, muscle atrophy, or contracture. The aim of this study is to investigate the value of venous blood gas (VBG), which is an easier and less complicated method, among stable patients with OHS and NMD. METHODS: The study included stable OHS and NMD patients who had been previously diagnosed and followed up between March 2017 and May 2017 in the outpatient clinic. ABG was taken from all patients in room air, and peripheral VBG was taken within 5 min after ABG sampling. RESULTS: Thirty-six patients with OHS and 46 patients with NMD were included in the study. There was a moderate positive correlation between arterial and venous pH values for all patients (rs= 0.590, P < 0.001). There were a strong and very strong positive correlations between arterial and venous pCO2and HCO3values (rs= 0.725 and rs= 0.934, respectively) (P < 0.001). There was no correlation between arterial and venous pO2and saturation values. There was an agreement in Bland–Altman method for the values of ABG and VBG (pH, pCO2, and HCO3). CONCLUSIONS: There was a correlation between ABG and VBG values (pH, pCO2, and HCO3). VBG parameters (pH, pCO2, and HCO3) can be used safely instead of ABG parameters which have many risks, during treatment and follow-up of patients with OHS and NMD. [ABSTRACT FROM AUTHOR]
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- 2019
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173. Nocturnal Hypoventilation May Have a Protective Effect on Ischemic Heart Disease in Patients with Obesity Hypoventilation Syndrome.
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Castellana, Giorgio, Dragonieri, Silvano, Marra, Lorenzo, Quaranta, Vitaliano N., Carratù, Pierluigi, Ranieri, Teresa, Resta, Onofrio, and Quaranta, Vitaliano
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HYPOVENTILATION , *CORONARY disease , *CARDIAC patients , *OVERWEIGHT persons , *SYNDROMES , *PULMONARY function tests , *CORONARY heart disease prevention , *PICKWICKIAN syndrome , *SLEEP apnea syndromes , *COMORBIDITY , *BODY mass index , *RETROSPECTIVE studies - Abstract
The importance of nocturnal hypoventilation (nHyp) in the development of cardiovascular comorbidity (CVM) in patients with obesity hypoventilation syndrome (OHS) is controversial. We recently hypothesized that nHyp may have a protective effect on CVM in OHS. The aim of this study was to evaluate the link between nHyp and CVM in patients with OHS. We performed a retrospective analysis of the clinical records of 60 patients with OHS. The initial population was divided into two groups: (1) 31 subjects with OHS and nHyp (nhOHS); (2) 29 individuals with OHS without nHyp (wnhOHS). All patients had also obstructive sleep apnea. Anthropometric data, medical history, electrocardiogram, pulmonary function testing, arterial blood gas test, and sleep recordings were collected. Patients with nhOHS, compared with those wnhOHS, showed higher values of PaCO2 (48.75 ± 3.78 vs. 46.91 ± 2.09 mmHg; p = 0.023), lower percentage of ischemic heart disease (3.2% vs. 20.7%; p = 0.042), higher oxygen desaturation index (ODI; 55.10/h ± 28.76 vs. 38.51/h ± 23.21; p = 0.017), and higher total sleep time (TST90) with SpO2 <90% (53.58% ± 26.90 vs. 25.64% ± 21.67; p = 0.000). Moreover, individuals in the nhOHS group showed a significantly different (p = 0.031) distribution of the three ODI tertiles 0-32/h, 33-72/h, >72/h compared with those in wnhOHS group (19.4% vs. 37%, 41.9% vs. 51.7%, 38.7% vs. 10.3%, respectively). Subsequent discriminant analysis correctly classified nhOHS and wnhOHS in 66.7% of the cases. Ours is the first study analyzing the correlation between nHyp and CVM in patients with OHS. We showed that nHyp in OHS may have a protective effect on cardiovascular morbidity, in particular on ischemic cardiac disease. [ABSTRACT FROM AUTHOR]
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- 2019
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174. Efficacy of bilevel ventilatory support in the treatment of stable patients with obesity hypoventilation syndrome: systematic review and meta-analysis.
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Royer, Caroline Persch, Schweiger, Cláudia, Manica, Denise, Rabaioli, Luisi, Guerra, Vinicius, and Sbruzzi, Graciele
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PICKWICKIAN syndrome , *VENTILATION , *CONTINUOUS positive airway pressure , *MEDICAL databases , *META-analysis - Abstract
Objective: To systematically review the effects of bilevel ventilatory support (BVS) in patients with Obesity Hypoventilation Syndrome (OHS).Methods: A search of databases (MEDLINE accessed by PubMed, Cochrane CENTRAL, EMBASE and LILACS) was conducted from inception to June 2018. Randomized trials comparing BVS to other therapeutic modalities such as lifestyle counseling, continuous positive airway pressure (PAP) or BVS with average volume assured pressure support for the treatment of patients with OHS were included. The primary outcome was a change in daytime arterial carbon dioxide levels (PaCO2). Secondary outcome measures included arterial partial pressure of oxygen (PaO2), blood bicarbonate (HCO3), percentage of total sleep time (TST) with oxygen saturation <90%, transcutaneous pressure of carbon dioxide (PtcCO2), Epworth Sleepiness Scale (ESS), Medical Outcome Survey Short Form (SF36), Functional Outcomes of Sleep Questionnaire (FOSQ), Severe Respiratory Insufficiency Questionnaire (SRI), compliance with treatment, and weight loss.Results: Of 176 articles identified, seven studies were included. When BVS was compared to lifestyle counseling, the intervention was superior in improving PaCO2 (-2.90 mmHg; 95%CI -4.28 to -1.52), PaO2 (2.89 mmHg; 95%CI 0.33 to 5.46), HCO3 (-2.55 mmol/L; 95%CI -3.28 to -1.81), percentage of TST<90% (-30.55%; 95%CI -37.98 to -23.12), ESS (-2.52; 95%CI -4.16 to -0.88) and FOSQ (6.33; 95%CI 1.78 to 10.88). However, when BVS was compared to other PAP modalities, there was no difference in any of the outcomes evaluated.Conclusions: Treatment using BVS therapy is superior to lifestyle counseling. Different PAP modalities appear to be equally effective in improving outcomes. CRD42017065326. [ABSTRACT FROM AUTHOR]- Published
- 2019
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175. Burden of primary influenza and respiratory syncytial virus pneumonia in hospitalised adults: insights from a 2‐year multi‐centre cohort study (2017–2018)
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Cristina Costa, Lourenço Cruz, Maria Inês Moreira, Matteo Boattini, Eirini Christaki, Georgios Tsiolakkis, Lorena Charrier, Gabriele Bianco, Panagiota Maikanti, Rossana Cavallo, Diogo Antão, Marco Iannaccone, Torcato Moreira Marques, Christos Karagiannis, Valentina Tosatto, and André M. Almeida
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Obesity hypoventilation syndrome ,medicine.medical_specialty ,business.industry ,medicine.disease ,Virus ,Pneumonia ,Internal medicine ,Viral pneumonia ,Internal Medicine ,medicine ,Breathing ,Multi centre ,business ,Respiratory syncytial virus pneumonia ,Cohort study - Abstract
Viral community-acquired pneumonia (CAP) is a potentially serious illness, particularly in adult patients with underlying chronic conditions. In addition to the most recent SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) are considered the most relevant causes of viral CAP.To describe the clinical features of hospitalised adults admitted for influenza-A/B and RSV pneumonia and analyse, according to aetiology, factors associated with non-invasive ventilation (NIV) failure and in-hospital death (IHD).This was a retrospective and multi-centre study of all adults who were admitted for laboratory-confirmed influenza-A/B or RSV pneumonia, during two consecutive winter seasons (October-April 2017-2018 and 2018-2019) in three tertiary hospitals in Portugal, Italy and Cyprus.A total of 356 adults were included in the study. Influenza-A, influenza-B and RSV were deemed to cause pneumonia in 197 (55.3%), 85 (23.9%) and 74 (20.8%) patients, respectively. Patients with both obstructive sleep apnoea or obesity hypoventilation syndrome and influenza-A virus pneumonia showed a higher risk for NIV failure (odds ratio (OR) 4.66; 95% confidence interval (CI) 1.42-15.30). Patients submitted to NIV showed a higher risk for IHD, regardless of comorbidities (influenza-A OR 3.00; 95% CI 1.35-6.65, influenza-B OR 4.52; 95% CI 1.13-18.01, RSV OR 5.61; 95% CI 1.26-24.93).The increased knowledge of influenza-A/B and RSV pneumonia burden may contribute to a better management of patients with viral CAP.
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- 2022
176. Effect of different modes of positive airway pressure treatment on obesity hypoventilation syndrome: a systematic review and network meta-analysis
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Jiahuan, Xu, Zhijing, Wei, Wenyang, Li, and Wei, Wang
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Continuous Positive Airway Pressure ,Polysomnography ,Network Meta-Analysis ,Obesity Hypoventilation Syndrome ,Quality of Life ,Humans ,General Medicine ,Carbon Dioxide - Abstract
To perform a systematic review and network meta-analysis to provide comparative evidence and quantitative hierarchies of the effectiveness of positive airway pressure (PAP) treatment on obesity hypoventilation syndrome (OHS).We searched PubMed, Embase, and Cochrane Library databases for relevant articles about the treatment of OHS published from the time of database creation to February 2021. Two independent reviewers performed the study search and screening, quality assessment and data extraction. The network meta-analysis within the frequentist framework was performed using Stata 15.0. The outcomes included changes in arterial blood gases, sleep quality, and polysomnography parameters.Ten articles were included in the study. The results of the network meta-analysis showed that PAP treatment could decrease the partial pressure of carbon dioxide, bicarbonate level, apnea-hypopnea index, Epworth sleepiness scale score, and percentage of light sleep, and increase the partial pressure of oxygen, oxygen saturation, and percentage of rapid eye movement sleep and deep sleep when compared with control group in OHS patients. In addition, the results of the derived hierarchy showed that BPAP-AVAPS and BPAP-ST were the first two modes of PAP treatment that reduced the partial pressure of carbon dioxide and percentage of light sleep and improved the percentage of rapid eye movement sleep and deep sleep. However, there was no difference in the quality of life, total sleep time, and sleep efficiency between any mode of PAP treatment and the control group.PAP treatment is beneficial for OHS patients, and the modes of BPAP-AVAPS and BPAP-ST demonstrated the largest improvement in hypercapnia and objective sleep structure.
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- 2022
177. Severity stages of obesity-related breathing disorders – a cross-sectional cohort study
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Simon D. Herkenrath, Marcel Treml, Lars Hagmeyer, Sandhya Matthes, and Winfried J. Randerath
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Cross-Sectional Studies ,Obesity Hypoventilation Syndrome ,Humans ,Obesity ,Prospective Studies ,General Medicine ,Blood Gas Monitoring, Transcutaneous ,Body Mass Index - Abstract
There is a general underappreciation of the spectrum of obesity-related breathing disorders and their consequences. We therefore compared characteristics of obese patients with eucapnic obstructive sleep apnea (OSA), OSA with obesity-related sleep hypoventilation (ORSH) or obesity hypoventilation syndrome (OHS) to identify the major determinants of hypoventilation.In this prospective, diagnostic study (NCT04570540), obese patients with OSA, ORSH or OHS were characterized applying polysomnography with transcutaneous capnometry, blood gas analyses, bodyplethysmography and measurement of hypercapnic ventilatory response (HCVR). Pathophysiological variables known to contribute to hypoventilation and differing significantly between the groups were specified as potential independent variables in a multivariable logistic regression to identify major determinants of hypoventilation.Twenty, 43 and 19 patients were in the OSA, ORSH and OHS group, respectively. BMI was significantly lower in OSA as compared to OHS. The extent of SRBD was significantly higher in OHS as compared to OSA or ORSH. Patients with ORSH or OHS showed a significantly decreased forced expiratory volume in 1 s and forced vital capacity compared to OSA. HCVR was significantly lower in OHS and identified as the major determinant of hypoventilation in a multivariable logistic regression (Nagelkerke RAlthough there were differences in BMI, respiratory mechanics and severity of upper airway obstruction between groups, our data support HCVR as the major determinant of obesity-associated hypoventilation.
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- 2022
178. Obesity hypoventilation syndrome: a current review.
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de Athayde, Rodolfo Augusto Bacelar, de Oliveira Filho, José Ricardo Bandeira, Filho, Geraldo Lorenzi, and Genta, Pedro Rodrigues
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NONINVASIVE ventilation ,HYPOVENTILATION ,CONTINUOUS positive airway pressure ,OBESITY ,BICARBONATE ions - Abstract
Obesity hypoventilation syndrome (OHS) is defined as the presence of obesity (body mass index ≥ 30 kg/m²) and daytime arterial hypercapnia (PaCO
2 ≥ 45 mmHg) in the absence of other causes of hypoventilation. OHS is often overlooked and confused with other conditions associated with hypoventilation, particularly COPD. The recognition of OHS is important because of its high prevalence and the fact that, if left untreated, it is associated with high morbidity and mortality. In the present review, we address recent advances in the pathophysiology and management of OHS, the usefulness of determination of venous bicarbonate in screening for OHS, and diagnostic criteria for OHS that eliminate the need for polysomnography. In addition, we review advances in the treatment of OHS, including behavioral measures, and recent studies comparing the efficacy of continuous positive airway pressure with that of noninvasive ventilation. [ABSTRACT FROM AUTHOR]- Published
- 2018
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179. Patterns of use, survival and prognostic factors in patients receiving home mechanical ventilation in Western Australia: A single centre historical cohort study.
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Tan, Geak Poh, McArdle, Nigel, Dhaliwal, Satvinder Singh, Douglas, Jane, Rea, Clare Siobhan, and Singh, Bhajan
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Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m
−2 ) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%). On average, the patients had moderate ventilatory impairment (forced vital capacity: 51%predicted), sleep apnoea (apnoea-hypopnea index: 25 events h−1 ), sleep-related hypoventilation (transcutaneous carbon dioxide rise of 20 mmHg) and daytime hypercarbia (PCO2 : 54 mmHg). Median durations of survival from HMV initiation were 1.0, 4.2, 9.9 and >11.5 years for MND, PULM, NMCW and OHS, respectively. Independent predictors of death varied between primary indications for HMV; the predictors included (a) age in all groups except for MND (hazard ratios (HRs) 1.03–1.10); (b) cardiovascular disease (HR: 2.35, 95% confidence interval (CI): 1.08–5.10) in MND; (c) obesity (HR: 0.28, 95% CI: 0.13–0.62) and oxygen therapy (HR: 0.33, 95% CI: 0.14–0.79) in PULM; and (d) forced expiratory volume in 1 s (%predicted; HR: 0.93, 95% CI: 0.88–1.00) in OHS. [ABSTRACT FROM AUTHOR]- Published
- 2018
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180. Use of Polysomnography for Non-Invasive Ventilation Settings' Optimization (NIV-OHS)
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EMEA Clinical Affairs Director
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- 2008
181. Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome.
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Pobeha, P., Paranicova, I., Trojova, I., Tkacova, R., and Joppa, P.
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NONINVASIVE ventilation , *ARTIFICIAL respiration , *HEMODYNAMICS , *OBESITY , *HYPOVENTILATION - Abstract
OBJECTIVE: To evaluate the acute effects of volume-targeted non-invasive ventilation (NIV) on hemodynamic parameters assessed by impedance cardiography in patients with obesity hypoventilation syndrome (OHS). BACKGROUND: Despite the well-described beneficial effects of NIV using volume-targeted pressure support ventilation modes on respiration in OHS patients, questions were raised about the impact of this treatment on the cardiovascular system. METHODS: In 15 patients (10 men; mean age, 55.8±9.3 years) impedance cardiography recordings were taken at baseline, after 120 minutes while on NIV and 20 minutes after NIV termination. A repeated-measures analysis of variance was used for comparisons. RESULTS: Compared to baseline, a reduction in heart rate (from 80±11 to 73±10 beats per min, p<0.05) was observed on NIV whereas the stroke volume and cardiac index remained stable throughout all three assessed intervals (p=0.347, p=0.344; respectively). The pre-ejection period increased on NIV (from 113±16 to 127±20 ms, p<0.05), and the left ventricular ejection time increased after NIV termination compared to baseline (from 259±25 to 269±25 ms, p<0.05). CONCLUSION: Volume-targeted NIV may acutely improve systolic time intervals without any negative impact on the left ventricular function in OHS patients. [ABSTRACT FROM AUTHOR]
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- 2021
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182. Researchers from Semmelweis University Provide Details of New Studies and Findings in the Area of Obesity Hypoventilation Syndrome (Using intra-breath oscillometry in obesity hypoventilation syndrome to detect tidal expiratory flow limitation:...).
- Abstract
Researchers from Semmelweis University have conducted a study on obesity hypoventilation syndrome (OHS) and its treatment with continuous positive airway pressure (CPAP) therapy. The study used intra-breath oscillometry to optimize CPAP therapy for OHS patients. The researchers found that stepwise CPAP application can diminish tidal expiratory flow limitation (tEFL) in most patients, and intra-breath oscillometry is a viable method to detect tEFL during CPAP initiation. This research provides valuable insights into the assessment and treatment of OHS, highlighting the potential for optimizing therapy by targeting tEFL. [Extracted from the article]
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- 2023
183. Efficacy of Average Volume Assured Pressure Support With Bi-Level Pressure Support Nocturnal Ventilation
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Ligue Pulmonaire Genevoise
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- 2007
184. A rare association: Obesity hypoventilation syndrome with myasthenia gravis and systemic lupus erythematosus, case report.
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Eldaabossi, Safwat, Alrashdan, Man, Aljanobi, Ghada, Warsha, Noha, Abo Elhassan, Saber, Mahdi, Waheed, Farouk, Abdullah, Taha, Ahmad, Qabil, Ahmad, Maklad, Sameh, Nabway, Usama, Kenany, Hatem, Jaber, Yasser, and Zaghloul, Boshra
- Abstract
Shrinking lung syndrome (SLS) is an uncommon complication of systemic lupus erythematosus (SLE) that has also been seen in other autoimmune diseases and is linked with a high risk of acute or chronic respiratory failure. Alveolar hypoventilation in the presence of obesity-hypoventilation syndrome, systemic lupus erythematosus (SLE), and myasthenia gravis (MG) is uncommon and poses a diagnostic and therapeutic challenge. We reported a 33-year-old female patient from Saudi Arabia who suffered from obesity, bronchial asthma, newly diagnosed essential hypertension, type 2 diabetes mellitus, with recurrent acute alveolar hypoventilation, secondary to obesity hypoventilation syndrome and mixed autoimmune disease (systemic lupus erythematosus and myasthenia gravis), based on the correct constellation of clinical findings and laboratory evidence. The interesting aspect of this case report: is the presentation of the overlap of obesity hypoventilation syndrome and shrinking lung syndrome due to systemic lupus erythematosus with generalized and respiratory muscle dysfunction due to myasthenia gravis with good outcomes after therapy. [ABSTRACT FROM AUTHOR]
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- 2023
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185. The Danish National Database for Obstructive Sleep Apnea
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Jennum PJ, Larsen P, Cerqueira C, Schmidt T, and Tønnesen P
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Obstructive sleep apnea ,obesity hypoventilation syndrome ,quality of care ,clinical registry ,Infectious and parasitic diseases ,RC109-216 - Abstract
Poul Jørgen Jennum,1 Preben Larsen,2 Charlotte Cerqueira,3 Thor Schmidt,4 Philip Tønnesen1 1Department of Clinical Neurophysiology, Faculty of Health Sciences, Danish Center for Sleep Medicine, University of Copenhagen, Rigshospitalet, Copenhagen, 2Section of Respiratory Disease, Medical Department, Fredericia Hospital, Fredericia, 3Registry Support Centre (East) – Epidemiology and Biostatistics, Research Centre for Prevention and Health, 4Registry Support Centre (East) – Clinical Quality Improvement and Health Informatics, Capital Region of Denmark, Copenhagen, Denmark Aim: The aim of the Danish National Database for Obstructive Sleep Apnea (NDOSA) was to evaluate the clinical quality (diagnostic, treatment, and management) for obstructive sleep apnea and obesity hypoventilation syndrome in Denmark using a real-time national database reporting to the Danish National Patient Registry. Study population: All patients diagnosed with obstructive sleep apnea or obesity hypoventilation syndrome at public and private in- and out-hospital departments in Denmark were included. Main variables: The NDOSA contains information about baseline characteristics, comorbidity, diagnostic procedures conducted, treatment (continuous positive airway pressure and similar treatments, surgery, mandibular advancement devices, etc) complications, and treatment status. Descriptive data: Yearly report with indicators for diagnostic procedures, treatment, and follow-up comparing different departments was involved in the management of sleep apnea in Denmark for the purpose of quality improvement. Conclusion: The NDOSA has proven to be a real-time national database using diagnostic and treatment procedures reported to the Danish National Patient Registry. Keywords: obstructive sleep apnea, obesity hypoventilation syndrome, quality of care, clinical registry
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- 2016
186. The clinical characteristics and hospital and post‐hospital survival of patients with the obesity hypoventilation syndrome: analysis of a large cohort
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P. E. Marik and C. Chen
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Mortality ,obesity ,obesity hypoventilation syndrome ,sleep discorded breathing ,Internal medicine ,RC31-1245 - Abstract
Summary Objective The worldwide prevalence of obesity has reached epidemic proportions. Obesity hypoventilation syndrome (OHS) is a common yet largely undiagnosed and mistreated condition that likely carries a high mortality. The aim of this study was to determine the clinical characteristics, hospital outcome, outcome following hospital discharge and predictors of death in a large cohort of patients hospitalized with OHS. OHS is an important condition as many patients with this syndrome are misdiagnosed and receive inappropriate treatment. Methods We reviewed the electronic medical records of patients with unequivocal OHS admitted to a 525‐bed tertiary‐care teaching hospital over a 5‐year period. Demographic and clinical data as well as hospital disposition were recorded. In order to determine the patients' post‐discharge status, we linked our database to the database of death certificates of the State Registrar of Vital Records. Results We identified 600 patients who met the inclusion criteria for this study. The patients' mean age was 58 ± 15 years with a mean body mass index of 48.2 ± 8.3 kg m−2; 64% were women. Thirty‐seven percent had a history of diabetes and 43% had been misdiagnosed as having chronic obstructive pulmonary disease, while none had been previously diagnosed with OHS. The most common admission diagnoses were respiratory failure, heart failure and sepsis. Ninety (15%) patients died during the index hospitalization. The patients' age, S‐creatinine, respiratory failure, sepsis and admission to the ICU were independent predictors of hospital mortality. The hospital survivors were followed for a mean of 1,174 ± 501 d (3.2 ± 1.3 years) from the index hospitalization. On follow‐up, 98 of the 510 (19%) hospital survivors died, with an overall cumulative mortality of 31.3%. The patients' age, S‐creatinine and admission to the ICU were independent predictors of post‐hospital mortality. Conclusion Obesity hypoventilation syndrome is a common disease that is frequently misdiagnosed and mistreated and carries a 3‐year morality, which is significantly worse than that for most cancers combined. Considering the high mortality of this disease, all patients with a body mass index > 35 kg m−2 should be screened for OHS; those patients with both early and established OHS should be referred to a pulmonary and/or sleep specialist for evaluation for non‐invasive positive pressure ventilation, to a dietician for dietary counseling and lifestyle modification and to a bariatric surgeon for evaluation for bariatric surgery.
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- 2016
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187. Results of the home mechanical ventilation national program among adults in Chile between 2008 and 2017
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Patricia Rivas, Sandra Zapata, María Elena Torres, Ángela Venegas, Marianela Andrade, Jorge Villalobos, Cesar Maquilon, Krishnna Canales, Carmen Andrade, Cristian Olave, Nicolás Valdés, Claudio Rabec, Miguel Aguayo, Monica Antolini, and Osvaldo Cabrera
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Neuromuscular disease ,medicine.medical_treatment ,Respiratory Tract Diseases ,Young Adult ,Diseases of the respiratory system ,Quality of life ,Internal medicine ,medicine ,Humans ,Chronic respiratory failure ,Prospective Studies ,Chile ,Prospective cohort study ,Survival rate ,Aged ,Mechanical ventilation ,Obesity hypoventilation syndrome ,COPD ,Long term ventilation ,RC705-779 ,business.industry ,Research ,Middle Aged ,medicine.disease ,Home Care Services ,Respiration, Artificial ,Home mechanical ventilation ,Quality of Life ,Female ,Domiciliary ventilation ,Respiratory Insufficiency ,business ,Body mass index - Abstract
Background Home mechanical ventilation (HMV) is a viable and effective strategy for patients with chronic respiratory failure (CRF). The Chilean Ministry of Health started a program for adults in 2008. Methods This study examined the following data from a prospective cohort of patients with CRF admitted to the national HMV program: characteristics, mode of admission, quality of life, time in the program and survival. Results A total of 1105 patients were included. The median age was 59 years (44–58). Women accounted for 58.1% of the sample. The average body mass index (BMI) was 34.9 (26–46) kg/m2. A total of 76.2% of patients started HMV in the stable chronic mode, while 23.8% initiated HMV in the acute mode. A total of 99 patients were transferred from the children's program. There were 1047 patients on non-invasive ventilation and 58 patients on invasive ventilation. The median baseline PaCO2 level was 58.2 (52–65) mmHg. The device usage time was 7.3 h/d (5.8–8.8), and the time in HMV was 21.6 (12.2–49.5) months. The diagnoses were COPD (35%), obesity hypoventilation syndrome (OHS; 23.9%), neuromuscular disease (NMD; 16.3%), non-cystic fibrosis bronchiectasis or tuberculosis (non-CF BC or TBC; 8.3%), scoliosis (5.9%) and amyotrophic lateral sclerosis (ALS; 5.24%). The baseline score on the Severe Respiratory Insufficiency questionnaire (SRI) was 47 (± 17.9) points and significantly improved over time. The lowest 1- and 3-year survival rates were observed in the ALS group, and the lowest 9-year survival rate was observed in the non-CF BC or TB and COPD groups. The best survival rates at 9 years were OHS, scoliosis and NMD. In 2017, there were 701 patients in the children's program and 722 in the adult´s program, with a prevalence of 10.4 per 100,000 inhabitants. Conclusion The most common diagnoses were COPD and OHS. The best survival was observed in patients with OHS, scoliosis and NMD. The SRI score improved significantly in the follow-up of patients with HMV. The prevalence of HMV was 10.4 per 100,000 inhabitants. Trial registration This study was approved by and registered at the ethics committee of North Metropolitan Health Service of Santiago, Chile (N° 018/2021).
- Published
- 2021
188. Optimal NIV Medicare Access Promotion: Patients With COPD
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Nicholas S. Hill, Gerard J. Criner, Richard D. Branson, Bartolome R. Celli, Neil R. MacIntyre, Amen Sergew, Peter C. Gay, Robert L. Owens, Lisa F. Wolfe, Joshua O. Benditt, Loutfi S. Aboussouan, John M. Coleman, Dean R. Hess, Timothy I. Morgenthaler, Atul Malhotra, Richard B. Berry, Karin G. Johnson, Marc I. Raphaelson, Babak Mokhlesi, Christine H. Won, Bernardo J. Selim, Barry J. Make, Bernie Y. Sunwoo, Nancy A. Collop, Susheel P. Patil, Alejandro D. Chediak, Eric J. Olson, and Kunwar Praveen Vohra
- Subjects
Pulmonary and Respiratory Medicine ,Obesity hypoventilation syndrome ,medicine.medical_specialty ,Central sleep apnea ,business.industry ,medicine.medical_treatment ,Sleep apnea ,Critical Care and Intensive Care Medicine ,medicine.disease ,Sleep medicine ,Apnea–hypopnea index ,Oxygen therapy ,Positive airway pressure ,medicine ,Continuous positive airway pressure ,Cardiology and Cardiovascular Medicine ,business ,Intensive care medicine - Abstract
This document summarizes suggestions of the central sleep apnea (CSA) Technical Expert Panel working group. This paper shares our vision for bringing the right device to the right patient at the right time. For patients with CSA, current coverage criteria do not align with guideline treatment recommendations. For example, CPAP and oxygen therapy are recommended but not covered for CSA. On the other hand, bilevel positive airway pressure (BPAP) without a backup rate may be a covered therapy for OSA, but it may worsen CSA. Narrow coverage criteria that require near elimination of obstructive breathing events on CPAP or BPAP in the spontaneous mode, even if at poorly tolerated pressure levels, may preclude therapy with BPAP with backup rate or adaptive servoventilation, even when those devices provide demonstrably better therapy. CSA is a dynamic disorder that may require different treatments over time, sometimes switching from one device to another; an example is switching from BPAP with backup rate to an adaptive servoventilation with automatic end-expiratory pressure adjustments, which may not be covered. To address these challenges, we suggest several changes to the coverage determinations, including: (1) a single simplified initial and continuing coverage definition of CSA that aligns with OSA; (2) removal of hypoventilation terminology from coverage criteria for CSA; (3) all effective therapies for CSA should be covered, including oxygen and all PAP devices with or without backup rates or servo-mechanisms; and (4) patients shown to have a suboptimal response to one PAP device should be allowed to add oxygen or change to another PAP device with different capabilities if shown to be effective with testing.
- Published
- 2021
189. Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia
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AIRWAY PRESSURE ,COPD pathology ,POSITIVE-PRESSURE VENTILATION ,OBESITY HYPOVENTILATION SYNDROME ,FULL FACE MASK ,RESPIRATORY-FAILURE ,non invasive ventilation ,HIGH-INTENSITY ,sleep apnoea ,OBSTRUCTIVE PULMONARY-DISEASE ,SLEEP-APNEA ,RANDOMIZED-TRIAL ,MECHANICAL VENTILATION - Abstract
BACKGROUND: The optimal interface for the delivery of home non-invasive ventilation (NIV) to treat chronic respiratory failure has not yet been determined. The aim of this individual participant data (IPD) meta-analysis was to compare the effect of nasal and oronasal masks on treatment efficacy and adherence in patients with COPD and obesity hypoventilation syndrome (OHS).METHODS: We searched Medline and Cochrane Central Register of Controlled Trials for prospective randomised controlled trials (RCTs) of at least 1 month's duration, published between January 1994 and April 2019, that assessed NIV efficacy in patients with OHS and COPD. The main outcomes were diurnal PaCO2, PaO2 and NIV adherence (PROSPERO CRD42019132398).FINDINGS: Of 1576 articles identified, 34 RCTs met the inclusion criteria and IPD were obtained for 18. Ten RCTs were excluded because only one type of mask was used, or mask data were missing. Data from 8 RCTs, including 290 IPD, underwent meta-analysis. Oronasal masks were used in 86% of cases. There were no differences between oronasal and nasal masks for PaCO2 (0.61 mm Hg (95% CI -2.15 to 3.38); p=0.68), PaO2 (-0.00 mm Hg (95% CI -4.59 to 4.58); p=1) or NIV adherence (0·29 hour/day (95% CI -0.74 to 1.32); p=0.58). There was no interaction between the underlying pathology and the effect of mask type on any outcome.INTERPRETATION: Oronasal masks are the most used interface for the delivery of home NIV in patients with OHS and COPD; however, there is no difference in the efficacy or tolerance of oronasal or nasal masks.
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- 2021
190. Executive Summary
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Peter C. Gay, Robert L. Owens, Lisa F. Wolfe, Joshua O. Benditt, Loutfi S. Aboussouan, John M. Coleman, Dean R. Hess, Nicholas S. Hill, Gerard J. Criner, Richard D. Branson, Bartolome R. Celli, Neil R. MacIntyre, Amen Sergew, Timothy I. Morgenthaler, Atul Malhotra, Richard B. Berry, Karin G. Johnson, Marc I. Raphaelson, Babak Mokhlesi, Christine H. Won, Bernardo J. Selim, Barry J. Make, Bernie Y. Sunwoo, Nancy A. Collop, Susheel P. Patil, Alejandro D. Chediak, Eric J. Olson, and Kunwar Praveen Vohra
- Subjects
Pulmonary and Respiratory Medicine ,Obesity hypoventilation syndrome ,medicine.medical_specialty ,Executive summary ,Central sleep apnea ,business.industry ,MEDLINE ,Critical Care and Intensive Care Medicine ,medicine.disease ,Sleep medicine ,Scientific evidence ,Family medicine ,Positive airway pressure ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Respiratory care - Abstract
The current national coverage determinations (NCDs) for noninvasive ventilation for patients with thoracic restrictive disorders, COPD, and hypoventilation syndromes were formulated in 1998. New original research, updated formal practice guidelines, and current consensus expert opinion have accrued that are in conflict with the existing NCDs. Some inconsistencies in the NCDs have been noted, and the diagnostic and therapeutic technology has also advanced in the last quarter century. Thus, these and related NCDs relevant to bilevel positive airway pressure for the treatment of OSA and central sleep apnea need to be updated to ensure the optimal health of patients with these disorders. To that end, the American College of Chest Physicians organized a multisociety (American Thoracic Society, American Academy of Sleep Medicine, and American Association for Respiratory Care) effort to engage experts in the field to: (1) identify current barriers to optimal care; (2) highlight compelling scientific evidence that would justify changes from current policies incorporating best evidence and practice; and (3) propose suggestions that would form the basis for a revised NCD in each of these 5 areas (thoracic restrictive disorders, COPD, hypoventilation syndromes, OSA, and central sleep apnea). The expert panel met during a 2-day virtual summit in October 2020 and subsequently crafted written documents designed to achieve provision of "the right device to the right patient at the right time." These documents have been endorsed by the participating societies following peer review and publication in CHEST and will be used to inform efforts to revise the current NCDs.
- Published
- 2021
191. Comprehensive care of a patient with obesity of BMI70 kg/m
- Author
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Shaila, Kabir, Abm Tofazzal, Hossain, Sadia Choudhury, Shimmi, and Choo Si, Jie
- Subjects
Adult ,Patient Care Team ,Motivation ,Continuous Positive Airway Pressure ,Diet, Reducing ,Multiple Organ Failure ,Bariatric Surgery ,Case Report ,Body Mass Index ,Exercise Therapy ,Obesity, Morbid ,Obesity Hypoventilation Syndrome ,Humans ,Female ,Acidosis, Respiratory - Abstract
A 31-year-old woman, with a body mass index of 70.31 kg/m(2), presented with progressive worsening of dyspnoea for 3 days. She had multiple comorbidities, including obesity hypoventilation syndrome. The patient developed type II respiratory failure with respiratory acidosis along with multiorgan failure. She was intubated and put on a mechanical ventilator and treated with intravenous diuretics, subcutaneous low-molecular-weight heparin and other supportive measures. Later, she was on noninvasive, continuous positive airway pressure ventilation overnight. She was prescribed a very-low-calorie diet along with physiotherapy and exercise. The patient underwent bariatric surgery 2 months after resolution of acute illness. Ten months after surgery, her body weight reduced from 180 kg to 121 kg, and her general condition improved. Successful management before and after surgical intervention depends on multidisciplinary teamwork, which includes the dietician, physiotherapist, endocrinologist, pulmonologist, nursing care and other supportive care.
- Published
- 2022
192. Use of Positive Airway Pressure in the Treatment of Hypoventilation
- Author
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Annie C. Lajoie and Marta Kaminska
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,Pulmonary Disease, Chronic Obstructive ,Neuropsychology and Physiological Psychology ,Noninvasive Ventilation ,Continuous Positive Airway Pressure ,Obesity Hypoventilation Syndrome ,Humans ,Neurology (clinical) ,General Medicine ,Hypoventilation - Abstract
The treatment of chronic hypoventilation usually requires noninvasive ventilation. However, upper airway obstruction can lead to hypoventilation in conditions such as obesity-hypoventilation syndrome, or chronic obstructive lung diseases (overlap syndrome). In these situations, continuous positive airway pressure can be an effective therapeutic option. This article reviews the pathophysiology of sleep-related hypoventilation, discusses situations where treatment with continuous positive airway pressure is feasible and briefly outlines noninvasive ventilation modes and settings for the treatment of common sleep-related hypoventilation disorders.
- Published
- 2022
193. Obesity Hypoventilation Syndrome
- Author
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Littleton, Stephen W., Mokhlesi, Babak, Dixon, Anne E., editor, and Clerisme-Beaty, Emmanuelle M., editor
- Published
- 2013
- Full Text
- View/download PDF
194. Mechanical Ventilation of Patients with Severe Obesity
- Author
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Litinski, Mikhail, Owens, Robert L., Malhotra, Atul, Dixon, Anne E., editor, and Clerisme-Beaty, Emmanuelle M., editor
- Published
- 2013
- Full Text
- View/download PDF
195. Study Findings on Obesity Hypoventilation Syndrome Are Outlined in Reports from Fudan University (Case report: fast reversal of malignant obesity hypoventilation syndrome after noninvasive ventilation and pulmonary rehabilitation)
- Subjects
Medical research ,Medicine, Experimental ,Obesity hypoventilation syndrome ,Physical fitness ,Health ,Fudan University - Abstract
2021 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on obesity hypoventilation syndrome is the subject of a new [...]
- Published
- 2021
196. Venovenous extracorporeal membrane oxygenation to treat hypercapnia in a morbidly obese patient
- Author
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Heidi Lederer, Magnus Stalder, Kai Tisljar, Fabio Lanzi, Emmanuelle Landmann, Tamina Mosimann, Franziska Zeeh, Stephan Zürcher, Vincent Mosimann, Rainer Spiegel, Raoul Sutter, and Patrick Hunziker
- Subjects
venovenous extracorporeal membrane oxygenation ,Noninvasive ventilation ,Sepsis ,hypercapnia ,obesity hypoventilation syndrome ,anuric kidney failure ,Medicine - Abstract
Morbid obesity plays an increasingly important role in healthcare. Patients who are severely obese often suffer from a range of medical problems. One problem is obesity-related hypoventilation syndrome with its resulting hypercapnia. We report a case of a 33-year-old female patient who was in an extraordinarily bad medical state, with severe hypercapnia (pCO2 15.1 kPa), sepsis, acute anuric kidney failure and resulting acidosis (pH 6.96). Her body mass index was 84 kg/m2. Her chances of survival were considered very low after failed attempts at noninvasive ventilation. Based on prior research, we refrained from intubation and chose venovenous extracorporeal membrane oxygenation to treat the hypercapnia. In the entire medical literature, we are not aware of a similarly extraordinary case of obesity-related hypoventilation syndrome that could finally be treated successfully. The idea behind this case report is to consider venovenous extracorporeal membrane oxygenation as an alternative to intubation in this patient collective.
- Published
- 2018
- Full Text
- View/download PDF
197. Acute hypercapnic respiratory failure and its management on the acute medical take
- Author
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Swapna Mandal, A Saigal, and Amar J Shah
- Subjects
Obesity hypoventilation syndrome ,medicine.medical_specialty ,Noninvasive Ventilation ,Modalities ,Acute hypercapnic respiratory failure ,Inpatient care ,business.industry ,General Medicine ,Respiratory physiology ,Audit ,medicine.disease ,Hospitalization ,Pulmonary Disease, Chronic Obstructive ,medicine ,Breathing ,Humans ,Respiratory Insufficiency ,Intensive care medicine ,business ,Patient comfort - Abstract
Acute hypercapnic respiratory failure accounts for 50 000 hospital admissions each year in the UK. This article discusses the pathophysiology and common causes of acute hypercapnic respiratory failure, and provides practical considerations for patient management in acute medical settings. Non-invasive ventilation for persistent acute hypercapnic respiratory failure is widely recognised to improve patient outcomes and reduce mortality. National audits highlight a need to improve patients' overall care and outcomes through appropriate patient selection and treatment initiation. Multidisciplinary involvement is essential, as this underpins inpatient care and follow up after hospital discharge. New non-invasive ventilation modalities may offer better patient comfort and compensate better for sleep-related changes in respiratory mechanics. Emerging therapies, such as nasal high flow, may offer an alternative treatment approach in those who cannot tolerate non-invasive ventilation, but more research is required to completely understand its effectiveness in treating acute hypercapnic respiratory failure.
- Published
- 2021
198. Case Studies in Physiology: Untangling the cause of hypoxemia in a patient with obesity with acute leukemia
- Author
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Iliya Amaza, Melissa L. Bates, Michael Eberlein, Bobby Wolfe, Hardik Kalra, Joseph McDonell, Michael H. Tomasson, and Yogesh Jethava
- Subjects
Male ,0301 basic medicine ,Physiology ,Partial Pressure ,030204 cardiovascular system & hematology ,Hypoxemia ,Blood cancer ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Humans ,Medicine ,Obesity ,Hypoxia ,Obesity hypoventilation syndrome ,Acute leukemia ,Leukemia ,business.industry ,medicine.disease ,Oxygen ,030104 developmental biology ,medicine.symptom ,business ,Case Studies in Physiology - Abstract
Diagnosing the cause of hypoxemia and dyspnea can be complicated in complex patients with multiple comorbidities. This “Case Study in Physiology” describes an man with obesity admitted to the hospital for relapse of acute lymphoblastic leukemia, who experienced progressive hypoxemia, shortness of breath, and dyspnea on exertion during his hospitalization. After initial empirical treatment with diuresis and antibiotics failed to improve his symptoms and because an arterial blood gas measurement was not readily available, we applied a novel, recently described physiological method to estimate the arterial partial pressure of oxygen from the peripheral saturation measurement and calculate the alveolar-arterial oxygen difference to discern the source of his hypoxemia and dyspnea. Using basic physiological principles, we describe how hypoventilation, anemia, and the use of a β blocker and furosemide, collaborated to create a “perfect storm” in this patient that impaired oxygen delivery and limited utilization. This case illustrates the application of innovative physiology methodology in medicine and provides a strong rationale for continuing to integrate physiology education in medical education. NEW & NOTEWORTHY Discerning the cause of dyspnea and hypoxemia in complex patients can be difficult. We describe the “real world” application of an innovative methodology to untangle the underlying physiology in a patient with multiple comorbidities. This case further demonstrates the importance of applying physiology to interrogate the underlying cause of a patient’s symptoms when treatment based on probability fails.
- Published
- 2021
199. Non‐invasive ventilation: A glimpse into the future.
- Author
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Chu, Chung‐Ming and Piper, Amanda
- Subjects
- *
NONINVASIVE ventilation , *OBSTRUCTIVE lung diseases - Abstract
Find the whole series here [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
200. Obstructive Sleep Apneu (OSA), Obesitas Hypoventilation Syndrome (OHS) dan Gagal Napas [Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome, and Respiratory Failure]
- Author
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Mokhammad Mukhlis and Arief Bakhtiar
- Subjects
obstructive sleep apnea ,obesity hypoventilation syndrome ,respiratory failure ,Medicine - Abstract
Background: Obstructive sleep apnea (OSA) is a state of the occurrence of upper airway obstruction periodically during sleep that causes breathing to stop intermittently, either complete (apnea) or partial (hipopnea). Obesity hypoventilation syndrome (OHS) is generally defined as a combination of obesity (BMI ≥ 30 kg / mc) with arterial hypercapnia while awake (PaCO2 > 45 mmHg) in the absence of other causes of hypoventilation. Purpose: In order for the pulomonologis can understand the pathogenesis and pathophysiology of OSA and its complications. Literature review: Several studies have been expressed about the link between OSA, OHS with respiratory failure disease. Pathophysiology of OSA, OHS in respiratory failure were difficult to detect, can cause respiratory failure disease management becomes less effective. Conclusion: A good understanding can help with the diagnosis and management of the appropriate conduct to prevent complications of respiratory failure associated with OSA.
- Published
- 2015
- Full Text
- View/download PDF
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