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151. The association between serum sex steroid hormone concentrations and intraprostatic inflammation in men without prostate cancer and irrespective of clinical indication for biopsy in the placebo arm of the Prostate Cancer Prevention Trial

Author

Chadid, Susan, primary, Barber, John R., additional, Nelson, William G., additional, Gurel, Bora, additional, Lucia, M. Scott, additional, Thompson, Ian M., additional, Goodman, Phyllis J., additional, Stanczyk, Frank Z., additional, Parnes, Howard L., additional, Lippman, Scott M., additional, De Marzo, Angelo M., additional, and Platz, Elizabeth A., additional

Published
2020
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160. Association of Serum Carotenoids and Retinoids with Intraprostatic Inflammation in Men without Prostate Cancer or Clinical Indication for Biopsy in the Placebo Arm of the Prostate Cancer Prevention Trial.

Author

Chadid, Susan, Song, Xiaoling, Schenk, Jeannette M., Gurel, Bora, Lucia, M. Scott, Thompson Jr., Ian M., Neuhouser, Marian L., Goodman, Phyllis J., Parnes, Howard L., Lippman, Scott M., Nelson, William G., De Marzo, Angelo M., and Platz, Elizabeth A.

Subjects
RETINOIDS, BIOPSY, HIGH performance liquid chromatography, BETA carotene, CONFIDENCE intervals, PROSTATITIS, CRYPTOXANTHIN, CAROTENOIDS, LYCOPENE, CAROTENES, VITAMIN A, LOGISTIC regression analysis, ODDS ratio, PROSTATE tumors
Abstract

Non-supplemental carotenoids and retinol may potentiate antioxidant and anti-inflammatory mechanisms. Chronic intraprostatic inflammation is linked to prostate carcinogenesis. We investigated the association of circulating carotenoids and retinol with intraprostatic inflammation in benign tissue. We included 235 men from the Prostate Cancer Prevention Trial placebo arm who had a negative end-of-study biopsy, most (92.8%) done without clinical indication. α-carotene, β-carotene, β-cryptoxanthin, lycopene, and retinol were assessed by high-performance liquid chromatography using pooled year 1 and 4 serum. Presence and extent of intraprostatic inflammation in benign tissue was assessed in 3 (of 6–10) biopsy cores. Logistic (any core with inflammation vs none) and polytomous logistic (some or all cores with inflammation vs none) regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of intraprostatic inflammation by concentration tertile adjusting for age, race, prostate cancer family history, and serum cholesterol. None of the carotenoids or retinol was associated with intraprostatic inflammation, except β-cryptoxanthin, which appeared to be positively associated with any core with inflammation [vs none, T2: OR (95% CI) = 2.67 (1.19, 5.99); T3: 1.80 (0.84, 3.82), P-trend = 0.12]. These findings suggest that common circulating carotenoids and retinol are not useful dietary intervention targets for preventing prostate cancer via modulating intraprostatic inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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165. Remediation at a marine Superfund site: surficial sediment PCB cogener concentration, composition, and redistribution

Author

Bergen, Barbara J., Rahn, Kenneth A., and Nelson, William G.

Subjects
Environmental issues, Science and technology
Abstract

Remediation of Massachusetts' New Bedford Harbor does not appear to significantly affect the levels of polychlorinated biphenyls (PCBs) within surficial sediment. The estuary is a Superfund site and is being monitored for the effects of the remediation effort. An analysis of the data using exploratory statistical techniques and a qualitative graphical technique helped determine subtle changes caused by the remediation effort that were not evident with measurements by traditional methods.

Published
1998

177. Nationally Representative Estimates of Serum Testosterone Concentration in Never-Smoking, Lean Men Without Aging-Associated Comorbidities

Author

Platz, Elizabeth A; https://orcid.org/0000-0003-3676-8954, Barber, John R, Chadid, Susan, Lu, Jiayun, Dobs, Adrian S, Kanarek, Norma F, Nelson, William G, Bradwin, Gary, McGlynn, Katherine A, Rohrmann, Sabine, Platz, Elizabeth A; https://orcid.org/0000-0003-3676-8954, Barber, John R, Chadid, Susan, Lu, Jiayun, Dobs, Adrian S, Kanarek, Norma F, Nelson, William G, Bradwin, Gary, McGlynn, Katherine A, and Rohrmann, Sabine

Abstract

Context Testosterone deficiency prevalence increases with age, comorbidities, and obesity. Objective To inform clinical guidelines for testosterone deficiency management and development of targets for nonpharmacologic intervention trials for these men, we determined serum testosterone in never-smoking, lean men without select comorbidities in nationally representative surveys. Design Setting Participants We used cross-sectional data for never-smoking, lean men ≥20 years without diabetes, myocardial infarction, congestive heart failure, stroke, or cancer, without use of hormone-influencing medications, and participated in morning sessions of National Health and Nutrition Examination Survey (NHANES) III (phase I 1988-1991) or continuous NHANES (1999-2004). By age, we determined median total testosterone (ng/mL) measured previously by a Food and Drug Administration-approved immunoassay and median estimated free testosterone concentration. Results In NHANES III, in never-smoking, lean men without comorbidities, median (25th, 75th percentile) testosterone was 4% to 9% higher than all men-20 to 39 years: 6.24 (5.16, 7.51), 40 to 59: 5.37 (3.83, 6.49), and ≥60: 4.61 (4.01, 5.18). In continuous NHANES, in never-smoking, lean men without comorbidities, levels were 13% to 24% higher than all men-20 to 39 years: 6.26 (5.32, 7.27), 40 to 59: 5.86 (4.91, 6.55), and ≥60: 4.22 (3.74, 5.73). In never-smoking, lean men without comorbidities, median estimated free testosterone was similar to (NHANES III) or slightly higher than (continuous NHANES) in all men. Conclusions These nationally representative data document testosterone levels (immunoassay) in never-smoking, lean men without select comorbidities 30 and 15 to 20 years ago. This information can be incorporated into guidelines for testosterone deficiency management and used to develop targets for nonpharmacologic intervention trials for testosterone deficiency.

Published
2019

178. Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples

Author

Chadid, Susan; https://orcid.org/0000-0003-4650-1073, Barber, John R, Rohrmann, Sabine, Nelson, William G, Yager, James D, Kanarek, Norma F, Bradwin, Gary, Dobs, Adrian S, McGlynn, Katherine A, Platz, Elizabeth A; https://orcid.org/0000-0003-3676-8954, Chadid, Susan; https://orcid.org/0000-0003-4650-1073, Barber, John R, Rohrmann, Sabine, Nelson, William G, Yager, James D, Kanarek, Norma F, Bradwin, Gary, Dobs, Adrian S, McGlynn, Katherine A, and Platz, Elizabeth A; https://orcid.org/0000-0003-3676-8954

Abstract

Purpose To report age-specific serum estradiol concentration in nonsmoking, lean US men without comorbidities. We provide concentrations from 30 and 15 to 20 years ago given previously described declines in serum estradiol in US men over time. Methods We used data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988 to 1991) and continuous NHANES (1999 to 2004). Serum estradiol and SHBG were previously measured by competitive electrochemiluminescence immunoassays. Free estradiol was estimated from estradiol, SHBG, and albumin. By age, we calculated median concentrations overall and for nonsmoking, lean (body mass index <25 kg/m$^{2}$ and waist <102 cm) men without diabetes, cardiovascular disease, or cancer. Results Overall, respective total estradiol medians for men ages 20 to 39, 40 to 59, and ≥60 years old were 37.0, 33.9, and 33.5 pg/mL in NHANES III and 31.3, 30.5, and 27.0 pg/mL in continuous NHANES. In nonsmoking, lean men without comorbidities, respective total estradiol medians were 32.0, 32.1, and 32.0 pg/mL in NHANES III and 29.1, 22.7, and 26.1 pg/mL in continuous NHANES. Overall, respective free estradiol medians were 0.82, 0.72, and 0.64 pg/mL in NHANES III and 0.67, 0.61, and 0.47 pg/mL in continuous NHANES. In nonsmoking, lean men without comorbidities, respective free estradiol medians were 0.64, 0.67, and 0.62 pg/mL in NHANES III and 0.58, 0.42, and 0.40 pg/mL continuous NHANES. Conclusion We report US nationally representative serum estradiol concentrations in healthy men, which could be used for targeting estradiol during testosterone supplementation and for general good health.

Published
2019

179. Selenium and sex steroid hormones in a US nationally representative sample of men: A role for the link between selenium and estradiol in prostate carcinogenesis?

Author

Van Hemelrijck, Mieke, Sollie, Sam, Nelson, William G, Yager, James D, Kanarek, Norma F, Dobs, Adrian, Platz, Elizabeth A, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Van Hemelrijck, Mieke, Sollie, Sam, Nelson, William G, Yager, James D, Kanarek, Norma F, Dobs, Adrian, Platz, Elizabeth A, and Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200

Abstract

BACKGROUND Given the recent findings from pooled studies about a potential inverse association between selenium levels and prostate cancer risk, the current cross-sectional study aimed to investigate the association between serum selenium and serum concentrations of sex steroid hormones including estradiol in a nationally representative sample of US men to investigate one mechanism by which selenium may influence prostate cancer risk. METHODS The study included 1,420 men aged 20 years or older who participated in the Third National Health and Nutrition Examination Survey (NHANES III) between 1988 and 1994. We calculated age/race-ethnicity-adjusted and multivariable-adjusted geometric mean serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) and compared them across quartiles of serum selenium. RESULTS Adjusting for age, race/ethnicity, smoking status, serum cotinine, household income, physical activity, alcohol consumption and percent body fat, mean total estradiol (e.g. Q1:38.00 pg/mL (95%CI:36.03-40.08) vs Q4:35.29 pg/mL (33.53-37.14); Ptrend=0.050)and free estradiol [e.g.Q1: 0.96 pg/mL (95%CI: 0.92-1.01) vs Q4: 0.90 (95%CI:0.85-0.95); Ptrend=0.065] concentrations decreased over quartiles of selenium. Stratification by smoking and alcohol consumption, showed that the latter observation was stronger for never smokers (Pinteraction=0.073) and those with limited alcohol intake (Pinteraction=0.017). No associations were observed for the other sex steroid hormones studied. CONCLUSION Our findings suggests that a possible mechanism by which selenium may be protective for prostate cancer is related to estrogen. IMPACT Further studies of longitudinal measurements of serum and toenail selenium in relation to serum measurements of sex steroid hormones are needed.

Published
2019

180. If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease

Author

Kulaç, İbrahim (ORCID 0000-0003-2003-7567 & YÖK ID 170305), Sfanos, Karen S.; Yegnasubramanian, Srinivasan; Nelson, William G.; Lotan, Tamara L.; Hicks, Jessica L.; Zheng, Qizhi; Bieberich, Charles J.; Haffner, Michael C.; De Marzo, Angelo M., School of Medicine, Department of Pathology, Kulaç, İbrahim (ORCID 0000-0003-2003-7567 & YÖK ID 170305), Sfanos, Karen S.; Yegnasubramanian, Srinivasan; Nelson, William G.; Lotan, Tamara L.; Hicks, Jessica L.; Zheng, Qizhi; Bieberich, Charles J.; Haffner, Michael C.; De Marzo, Angelo M., School of Medicine, and Department of Pathology

Abstract

Antibodies are employed ubiquitously in biomedical sciences, including for diagnostics and therapeutics. One of the most important uses is for immunohistochemical (IHC) staining, a process that has been improving and evolving over decades. IHC is useful when properly employed, yet misuse of the method is widespread and contributes to the "reproducibility crisis" in science. We report some of the common problems encountered with IHC assays, and direct readers to a wealth of literature documenting and providing some solutions to this problem. We also describe a series of vignettes that include our approach to analytical validation of antibodies and IHC assays that have facilitated a number of biological insights into prostate cancer and the refutation of a controversial association of a viral etiology in gliomas. We postulate that a great deal of the problem with lack of accuracy in IHC assays stems from the lack of awareness by researchers for the critical necessity for end-users to validate IHC antibodies and assays in their laboratories, regardless of manufacturer claims or past publications. We suggest that one reason for the pervasive lack of end-user validation for research antibodies is that researchers fail to realize that there are two general classes of antibodies employed in IHC. First, there are antibodies that are "clinical grade" reagents used by pathologists to help render diagnoses that influence patient treatment. Such diagnostic antibodies, which tend to be highly validated prior to clinical implementation, are in the vast minority (e.g. < 500). The other main class of antibodies are "research grade" antibodies (now numbering > 3 800 000), which are often not extensively validated prior to commercialization. Given increased awareness of the problem, both the United States, National Institutes of Health and some journals are requiring investigators to provide evidence of specificity of their antibody-based assays., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Cancer Center Support Grant; NIH/NCI SPORE in prostate Cancer; NIH/NCI; Patrick C. Walsh Prostate Cancer Research Fund; US Department of Defense Prostate Cancer Research Program; Prostate Cancer Biorepository Network (PCBN); Prostate Cancer Foundation

Published
2019

183. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

Author

Lee, Wen-Hsiang, Morton, Ronald A., Epstein, Jonathan I., Brooks, James D., Campbell, Pearl A., Bova, G. Steven, Hsieh, Wen-Son, Isaacs, William B., and Nelson, William G.

Subjects
Prostatitis -- Research, Glutathione transferase -- Research, Methylation -- Physiological aspects, Science and technology
Abstract

Human prostate carcinoma tissues do not express the pi-class glutathione S-transferase (GST) and the regulatory genes near the GSTP1 gene, which encode the human pi-class GST, undergo hypermethylation during prostatic carcinogenesis. GSTP1 is expressed in prostatic cancer cell lines having GSTP1 alleles that contain hypomethylated promoter sequences. However, prostatic cancer cells with hypermethylated GSTP1 promoter sequences fail to express GSTP1 mRNA or polypeptides.

Published
1994

185. Partitioning of polychlorinated congeners in the seawater of New Bedford Harbor, Massachusetts

Author

Bergen, Barbara J., Nelson, William G., and Pruell, Richard J.

Subjects
Polychlorinated biphenyls -- Research, Environmental issues, Science and technology
Abstract

The division of polychlorinated biphenyl congeners between particulate and dissolved phases of seawater along New Bedford Harbor, MA, was investigated using regression analysis. The results showed that the partitioning process was subject to seasonal trends. Around 70% of the variability in the log of the partition coefficients along the polychlorinated biphenyl gradient was due to temperature.

Published
1993

189. Contributors

Author

Abdul-Hussein, Mustafa, Abhyankar, Sunil, Adam, Rodney D., Adams, Paul C., Agudelo Higuita, Nelson Iván, Ahmed, Omar G., Akst, Lee, Anderson, Kelley P., Andre, Paul, Anstead, Gregory M., Aring, Ann M., Arshi, Arash, Avalos, Danny, Azar, Cecilio M., Azarbal, Amir, Baeseman, Zachary J., Bailey, Justin, Bajaj, Mandeep, Bakhutashvili, Vladimer, Balagué, Federico, Banti, Matthew, Barth, Bradley E., Basello, Gina M., Bassaly, Renee M., Bassily-Marcus, Adel, Baughn, Julie M., Belakovskiy, Aleksandr, Ben-Ami, Ronen, Bencheqroun, Hassan, Bernstein, David I., Bernstein, Jonathan A., Beyer, Caroline, Biggerstaff, Kristin Schmid, Birt, Mitchell, Blum, William, Bolotin, Diana, Bonnema, Rachel A., Borenstein, David, Bossart, Christopher, Bragg, Dee Ann, Bragg, Scott, Brice, Sylvia L., Briggs, Allyson M., Brill, John, Brown, Patricia D., Brown, Rachel, Buckley, Peter F., Burns, Sarah, Byrd, Kenneth, Cadavid, Diego, Caraccio, Thomas R., Carek, Peter J., Carrion, Andres F., Cass, Amanda S., Castell, Donald O., Catinella, Anthony Peter, Cayley, William E., Jr., Cerquozzi, Sonia, Cervera, Alvaro, Cetani, Filomena, Chamberlain, Rachel, Chan, Lawrence, Chan, Miriam, Chang, Zenas, Chen, Jimmy, Chen, Lin Yee, Chihara, Shingo, Chitlur, Meera, Chohan, Saima, Christensen, Jacob, Chyu, Kuang-Yuh, Cigarroa, Joaquin E., Cleland, Paul, Cline, Matthew K., Coates, Laura C., Colenbrander, August, Collins, Tracie C., Commins, Ryan M., Conageski, Christine, Conly, John M., Contini, Carlo, Cooper, Ashley, Cooper, Stacy, Cormier, Allison K., Cunha, Burke A., Cunha, Cheston B., Curry, Amy E., Dai, Julia, Daines, Cori L., Damas, Oriana M., Damitz, Beth A., Datta, Nandini, Dattilo, Natalie C., Davaro, Raul, David, Kevin A., de Leon, André, de Leon, Tate, DeCastro, Alexei O., DeGeorge, Katharine C., DeLoughery, Thomas G., Deodhar, Atul, Desai, Urmi, Dessinioti, Clio, Diamond, Michael P., Do, Catherine, Donnan, Geoffrey A., Dorsch, John N., Douglas, Chad, Dowlatshahi, Dar, Dowler, Shannon, Drevets, Douglas A., Dudley, Samuel C., Jr., Duggan, Peter R., Eagle, Kim, Eck, Leigh M., Egnatios, Genevieve L., Atrouni, Wissam El, Elston, Dirk M., Embil, John M., Epstein, Scott K., Evans, Susan, Evens, Andrew M., Fagan, J. Barry, Fairweather, Mark, Falk, Marni J., Faris, Anna, Faugno, Anthony J., III, Fayssoux, Kinder, Feldman, Dorianne, Fife, Terry D., Finley, David J., Firnhaber, Jonathon, Fisher, Lynn, Fisher, William E., Fleseriu, Maria, Fletcher, Donald C., Foster, Jeffrey Michael, Frank, Jennifer, Freeman, Ellen W., Frenz, David A., Gaba, Ruchi, Gaines, Melissa, Garcia, Mark E., Ghany, Marc G., Ghazi, Muhammad Ahmad, Gibney, Geoffrey, Gilbert, Donald L., Gilchrist, Karissa, Gillaspie, Erin A., Gilotra, Tarvinder, Gladwin, Mark T., Gluckman, Stephen J., Goddard, Andrew W., Goerl, Kyle, Gold, Mark S., Goldstein, Amy, González-Fernández, Marlis, Goodwin, Gregory, Gosmanov, Aidar R., Gradoni, Luigi, Graham, Timothy P., Grant-Kels, Jane M., Grdinovac, Kristine, Greenberg, Leslie A., Greene, William M., Greensher, Joseph, Gregory, David S., Greiwe, Justin, Hague, Melissa, Halder, Rebat M., Hall, Alan M., Harman, Lynn E., Harris, Kari R., Harrison, Taylor B., Hartman, Adam L., Haynes, James W., Heidelbaugh, Joel J., Hinshaw, Molly A., Hockenberry, Brandon, Hohl, Raymond J., Holguin, Therese, Holstein, Sarah A., Holyoak, Michael, Homan, Gretchen, Hommema, Kevin, Hommema, Laurie A.M., Horn, Leora, Hossani-Madani, Ahmad Reza, House, Steven A., Houssayni, Sarah, Hueston, William J., Huffstetler, Alison N., Ibidapo-Obe, Oyetokunbo, Irwin, Gretchen M., Isaac, Daniel, Isenberg, Gerald A., Jackson, Alan C., Jacobson, Kurt M., Jaller, Jose A., James, W. Ennis, Jia, Xiaoming, Johnson, Casey R., Johnson, Lisa M., Jolissaint, Joshua S., Judson, Marc A., Kadhiravan, Tamilarasu, Kalia, Rachna, Kamprath, Sagar, Rachel Kanter, Jessica, Karnad, Dilip R., Karnchanasorn, Rudruidee, Katsabas, Andreas, Katz, Ben Z., Katzman, Rebecca, Kaunitz, Andrew M., Keegan, B. Mark, Kellerman, Rick D., Kellermann, Scott, Kelly, Christina M., Khaki, Sheevaun, Kim, Arthur Y., Kim, Haejin, Kirsner, Robert S., Kiwalkar, Sonam, Knoefel, Janice, Kolb, Amanda, Kolla, Bhanu Prakash, Korley, Frederick K., Kovalsky, Adrienne N., Krause, Megan, Kraut, Eric H., Krishnamurti, Lakshmanan, Krishnan, Kumar, Kuhlmann, Zachary, Kulkarni, Roshni, Kumar, Seema, Kwaan, Mary R., Kyle, Robert A., Lampton, Lucius M., Lange, Richard A., Langlois, Fabienne, Larkin, Jerome, Lau, Christine L., Lawrence-Hylland, Susan, Lee, Lydia U., Leikin, Jerrold B., Leikin, Scott, Leung, Alexander K.C., LeWinter, Martin M., Lewis, Jennifer, Li, Ming, Liebenstein, Tyler K., Lin, Albert P., Linder, Jeffrey A., Lock, James, Long, M. Chantel, Loo-Gross, Colleen, Lun, Ronda, Mahvi, David A., Malhotra, Uma, Manlove, Emily, Manson, JoAnn E., Mansukhani, Meghna P., Marcocci, Claudio, Margo, Curtis E., Marker, Jason E., Martin, Paul, Mathis, Samuel E., Matson, Kristine, Matza, Mark A., Maxwell, Pinckney J., IV, May, Danica, Mazepa, Marshall, McClain, Molly, McGrew, Christopher, McGuigan, Christopher C., McGuigan, Michael, Mehta, Meetal, Meiselman, Mick S., Mercado, Moises, Merrell, Ryan, Meyers, Steven L., Miller, Brian J., Millington, Timothy M., Mirza, Moben, Mishra, Kriti, Mofenson, Howard C., Mogensen, Kris M., Moritz, Michael L., Mortada, Rami, Mortaji, Parisa, Moser, Scott E., Moss, Heather E., Moul, Judd W., Muller, Martha L., Mullen, Heidi E.K., Murinova, Natalia, Murphy, Michael, Muthusubramanian, Arjun, Nagji, Alykhan S., Nazeef, Moniba, Neelakantan, Viswanathan K., Neff, Donald A., Neil, Tara J., Nelson, William G., Neschis, David G., Nester, Theresa, Nguyen, Tam T., Nicol, Andrea L., Nieves-Arriba, Lucybeth, Novac, Andrei, Novelli, Enrico M., Nye, Lauren, Obi, Andrea T., Okeson, Jeffrey P., Oliveira, Carlos R., Ong, Peck Y., Oram, Daniel S., Osmani, Sabah, Ozgonenel, Bulent, Pacak, Karel, Padin-Rosado, José A., Padungkiatsagul, Tanyatuth, Paladine, Heather L., Pandolfino, John E., Patel, Deval, Patton, Simon, Penna, Gerson O., Penna, Maria Lucia, Perkins, Allen, Peterson, Leah, Petroianu, Georg A., Petronic-Rosic, Vesna M., Phan, Hanna, Pietroni, Mark, Pollart, Susan M., Porter, Andrew S.T., Powell, Charles R., Pusateri, Margaret, Quinn, James M., Rahko, Peter S., Rajkumar, S. Vincent, Rajpara, Anand, Rakel, David P., Ramakrishnan, Kalyanakrishnan, Ramirez, Julio A., Rana, Jatin, Rank, Matthew A., Raoult, Didier, Rapose, Alwyn, Rau, Rachel E., Ravindran, Anita Devi K., Regehr, Jared, Reid, Ian R., Rennert-May, Elissa, Rew, Karl T., Rezapour, Mona, Rhyne, Amanda, Riese, Martha, Robbins, David C., Robertson, Amy, Robinson, Malcolm K., Roche, William P., Rohrberg, Tessa E., Rose, Candice, Rose, Peter G., Ross, Stephen, Roth, Alan R., Ruha, Anne-Michelle, Rundell, Kristen, Said, Adnan, Sairenji, Tomoko, Samson, Susan L., Sanchez, Carlos E., Sangodkar, Sandeep, Santana, Arelis, Sarode, Ravi, Schatz, Michael, Schevchuck, Alex, Schiller, Lawrence R., Schrager, Sarina, Schuller, Dan, Seashore, Justin, Seery, Amy, Seifert, Steven A., Semel, Jeffery D., Shaffi, Saeed Kamran, Shah, Beejal, Shah, Meera, Shah, Prediman K., Shah, Samir S., Shah, Shenil, Shammo, Jamile M., Shapiro, Eugene D., Sharara, Ala I., Sharma, Sonal, Sheehan, John P., Sherman, Kamille S., Shevy, Laura Elyse, Shew, Sable, Sierpina, Victor S., Sievers, Karlynn, Silk, Hugh, Simon, Lisa, Sinclair, Aaron D., Siraj, Dawd S., Smith, Zachary L., Soder, Rupal, Sojka, John, Somers, William J., Song, Mihae, Sosa, Nestor, Sowder, Timothy, Speer, Linda, Spencer, Abby L., Stephens, Todd, St. Louis, Erik Kent, Stratakis, Constantine A., Stulberg, Daniel, Suárez, José Antonio, Takashima, Masayoshi, Takyar, Varun, Talhari, Carolina, Tang, Jie, Tate, Jessica, Templeton, Kim, Teng, Joyce M.C., Thomson, Joanna, Tillett, William, Timbadia, Paresh J., Tobin, Kenneth, Tsaltas, Theodore T., Unizony, Sebastian H., Unruh, Mark, Uppendahl, Locke, Vallurupalli, Anusha, Van Buren, George, II, van Duin, David, Van Durme, Daniel J., Varlamov, Elena V., Vélez, Christopher, Vercellotti, Gregory, Vincent, Kyle, Vinh, Donald C., Vyas, Jatin M., Wagner, Tamara, Wakefield, Thomas W., Wald, Arnold, Wald, Ellen R., Walker, Robin A., Wang, Ernest, Wang, Jennifer, Watanabe, Koji, Weber, Ruth, Wehler, Cheryl, Wei, Alice C., Weida, Jane A., Weissman, David N., Welliver, Robert C., Sr., Wester, Rebecca M., Westergaard, Ryan P., Wexler, Randell, Wilamowska, Katarzyna, Williams, Kimberly, Williams, Tracy L., Winterhoff, Boris, Wipperman, Jennifer, Wittler, Robert, Wolf, Katherine I., Wood, Gary S., Worswick, Scott, Wu, Dominic J., Wu, Steve W., Wyre, Hadley, Yakubov, Steven J., Yang, Xinghong, Yew, Kenneth S., Yi, Yooni, Yiannias, James A., and Young, Natawadee

Published
2022
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190. Trichomonas vaginalisinfection and prostate‐specific antigen concentration: Insights into prostate involvement and prostate disease risk

Author

Langston, Marvin E., primary, Bhalla, Ankita, additional, Alderete, John F., additional, Nevin, Remington L., additional, Pakpahan, Ratna, additional, Hansen, Johannah, additional, Elliott, Debra, additional, Marzo, Angelo M., additional, Gaydos, Charlotte A., additional, Isaacs, William B., additional, Nelson, William G., additional, Sokoll, Lori J., additional, Zenilman, Jonathan M., additional, Platz, Elizabeth A., additional, and Sutcliffe, Siobhan, additional

Published
2019
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194. A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

Author

Giovinazzo, Hugh, primary, Walker, David, additional, Wyhs, Nicolas, additional, Liu, Jianyong, additional, Esopi, David M., additional, Vaghasia, Ajay M., additional, Jain, Yash, additional, Bhamidipati, Akshay, additional, Zhou, Jianya, additional, Nelson, William G., additional, and Yegnasubramanian, Srinivasan, additional

Published
2019
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197. Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

Author

De Marzo Angelo M, Zheng Qizhi, Carvalho Benilton, Morgan James D, He Tony L, Badrinath Raghav, Aryee Martin J, Esopi David, Haffner Michael C, Wu Zhijin, Yegnasubramanian Srinivasan, Irizarry Rafael A, and Nelson William G

Subjects
DNA methylation, prostate cancer, tiling microarray, epigenetics, methylated DNA binding domain, MBD-chip, ADAMTS1, SCARF2, DSCR9, HLCS, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background DNA methylation has been linked to genome regulation and dysregulation in health and disease respectively, and methods for characterizing genomic DNA methylation patterns are rapidly emerging. We have developed/refined methods for enrichment of methylated genomic fragments using the methyl-binding domain of the human MBD2 protein (MBD2-MBD) followed by analysis with high-density tiling microarrays. This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells. Results Examining this data using computational methods that were designed specifically for DNA methylation tiling array data revealed widespread methylation of both gene promoter and non-promoter regions in cancer and normal cells. In addition to identifying several novel cancer hypermethylated 5' gene upstream regions that mediated epigenetic gene silencing, we also found several hypermethylated 3' gene downstream, intragenic and intergenic regions. The hypermethylated intragenic regions were highly enriched for overlap with intron-exon boundaries, suggesting a possible role in regulation of alternative transcriptional start sites, exon usage and/or splicing. The hypermethylated intergenic regions showed significant enrichment for conservation across vertebrate species. A sampling of these newly identified promoter (ADAMTS1 and SCARF2 genes) and non-promoter (downstream or within DSCR9, C21orf57 and HLCS genes) hypermethylated regions were effective in distinguishing malignant from normal prostate tissues and/or cell lines. Conclusions Comparison of chromosome-wide DNA methylation patterns in normal and malignant prostate cells revealed significant methylation of gene-proximal and conserved intergenic sequences. Such analyses can be easily extended for genome-wide methylation analysis in health and disease.

Published
2011
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200. The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Author

Basaria Shehzad, Rohrmann Sabine, Shiels Meredith S, Guallar Eliseo, Menke Andy, Rifai Nader, Nelson William G, and Platz Elizabeth A

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998–1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.

Published
2008
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