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Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
- Source :
- Proceedings of the National Academy of Sciences of the United States. Nov 22, 1994, Vol. 91 Issue 24, p11733, 5 p.
- Publication Year :
- 1994
-
Abstract
- Human prostate carcinoma tissues do not express the pi-class glutathione S-transferase (GST) and the regulatory genes near the GSTP1 gene, which encode the human pi-class GST, undergo hypermethylation during prostatic carcinogenesis. GSTP1 is expressed in prostatic cancer cell lines having GSTP1 alleles that contain hypomethylated promoter sequences. However, prostatic cancer cells with hypermethylated GSTP1 promoter sequences fail to express GSTP1 mRNA or polypeptides.
Details
- ISSN :
- 00278424
- Volume :
- 91
- Issue :
- 24
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16495963