1,135 results on '"Lemaitre, Rozenn N."'
Search Results
152. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals
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Mozaffarian, Dariush, Kumanyika, Shiriki K., Lemaitre, Rozenn N., Olson, Jean L., Burke, Gregory L., and Siscovick, David S.
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Cardiovascular diseases -- Prevention ,Cereal products -- Health aspects ,Fiber in human nutrition -- Health aspects - Abstract
The fiber in cereals and breads may reduce the risk of cardiovascular disease even in elderly people, according to a study of 3,588 people 65 years old and older who did not have cardiovascular disease. Those who ate the most cereal and bread fiber were 21% less likely to develop cardiovascular disease as those who ate the least. Cereal and bread fiber also lowered the risk of heart attack and stroke.
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- 2003
153. Effect of a low-fat diet on fatty acid composition in red cells, plasma phospholipids, and cholesterol esters: investigation of a biomarker of total fat intake
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King, Irena B, Lemaitre, Rozenn N, and Kestin, Mark
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- 2006
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154. Trans-fatty acids and sudden cardiac death
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Lemaitre, Rozenn N., King, Irena B., Mozaffarian, Dariush, Sootodehnia, Nona, and Siscovick, David S.
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- 2006
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155. Diuretic therapy, the [alpha]-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension. (Original Contribution)
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Psaty, Bruce M., Smith, Nicholas L., Heckbert, Susan R., Vos, Hans L., Lemaitre, Rozenn N., Reiner, Alexander P., Siscovick, David S., Bis, Joshua, Lumley, Thomas, Longstreth, W.T., Jr., and Rosendaal, Frits R.
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Genetic polymorphisms -- Health aspects ,Hypertension -- Genetic aspects ,Diuretics -- Health aspects ,Heart attack -- Prevention ,Stroke (Disease) -- Prevention - Abstract
People with a mutation in the gene for a protein called alpha adducin may benefit from treatment with diuretics to prevent a heart attack or stroke, according to a study of 1,038 people. This mutation causes salt-sensitive hypertension., Context A genetic variant in [alpha]-adducin has been associated with renal sodium reabsorption and salt-sensitive hypertension. Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown. Objectives To estimate the interaction between [alpha]-adducin and diuretic therapy on the risk of MI or stroke. Specifically, we hypothesized that in participants with treated hypertension, the risk of MI or stroke associated with diuretic use would be lower in carriers of the adducin variant than in carriers of the adducin wild-type genotype. Design, Setting, and Participants Population-based case-control study of patients enrolled in a health maintenance organization, treated pharmacologically for hypertension, and genotyped as homozygous carriers of the adducin wild-type genotype or carriers of i or 2 copies of the Trp460 variant allele. Cases had a first nonfatal MI (n=206) or stroke (n=117) between January 1995 and December 1998. Controls (n=715) were a stratified random sample of pharmacologically treated hypertensive patients who were matched to MI cases by age, sex, and calendar year. Main Outcome Measure Risk of the combined outcome of first nonfatal MI or stroke. Results The adducin variant was present in more than one third of the participants. Among the 653 carriers of the adducin wild-type genotype, diuretic therapy was not associated with the risk of Ml or stroke (odds ratio [OR], 1.09; 95% confidence interval [CI], 0.78-1.52). Among the 385 carriers of the adducin variant allele, diuretic therapy was associated with a lower risk of the combined outcome of Ml and stroke than other antihypertensive therapies (OR, 0.49; 95% CI, 0.32-0.77). The OR in carriers of the adducin variant was less than half of the OR in carriers of the wild-type genotype (P=.005). The case-control synergy index (SI) was 0.45 (95% CI, 0.26-0.79) for the combined outcome of MI and stroke. The point estimates of the diuretic-adducin interaction were similar in separate analyses of MI (SI, 0.41; 95% CI, 0.21-0.80) and stroke (SI, 0.53; 95% CI, 0.24-1.19). The diuretic-adducin interaction was not confounded by traditional cardiovascular risk factors, was specific to diuretic therapy but not pres ent for other major antihypertensive drug classes, and did not differ substantially between subgroups defined by age, sex, race, diabetes, and history of cardiovascular disease. Conclusions In carriers of the adducin variant, diuretic therapy was associated with a lower risk of combined Ml or stroke than other antihypertensive therapies. If these findings are confirmed in other studies, this large subgroup of the hypertensive population may be especially likely to benefit from low-dose diuretic therapy.
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- 2002
156. Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis
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Kanoni, Stavroula, Nettleton, Jennifer A., Hivert, Marie-France, Ye, Zheng, van Rooij, Frank J.A., Shungin, Dmitry, Sonestedt, Emily, Ngwa, Julius S., Wojczynski, Mary K., Lemaitre, Rozenn N., Gustafsson, Stefan, Anderson, Jennifer S., Tanaka, Toshiko, Hindy, George, Saylor, Georgia, Renstrom, Frida, Bennett, Amanda J., van Duijn, Cornelia M., Florez, Jose C., Fox, Caroline S., Hofman, Albert, Hoogeveen, Ron C., Houston, Denise K., Hu, Frank B., Jacques, Paul F., Johansson, Ingegerd, Lind, Lars, Liu, Yongmei, McKeown, Nicola, Ordovas, Jose, Pankow, James S., Sijbrands, Eric J.G., Syvänen, Ann-Christine, Uitterlinden, André G., Yannakoulia, Mary, Zillikens, M. Carola, Wareham, Nick J., Prokopenko, Inga, Bandinelli, Stefania, Forouhi, Nita G., Cupples, L. Adrienne, Loos, Ruth J., Hallmans, Goran, Dupuis, Josée, Langenberg, Claudia, Ferrucci, Luigi, Kritchevsky, Stephen B., McCarthy, Mark I., Ingelsson, Erik, Borecki, Ingrid B., Witteman, Jacqueline C.M., Orho-Melander, Marju, Siscovick, David S., Meigs, James B., Franks, Paul W., and Dedoussis, George V.
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- 2011
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157. Circulating Long-Chain ω-3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study: A Cohort Study
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Mozaffarian, Dariush, Lemaitre, Rozenn N., King, Irena B., Song, Xiaoling, Spiegelman, Donna, Sacks, Frank M., Rimm, Eric B., and Siscovick, David S.
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- 2011
158. The Trans-Ancestral Genomic Architecture of Glycaemic Traits
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Chen, Ji, primary, Spracklen, Cassandra N., additional, Marenne, Gaëlle, additional, Varshney, Arushi, additional, Corbin, Laura J, additional, Luan, Jian’an, additional, Willems, Sara, additional, Wu, Ying, additional, Zhang, Xiaoshuai, additional, Horikoshi, Momoko, additional, Boutin, Thibaud S, additional, Mägi, Reedik, additional, Waage, Johannes, additional, Pitsilides, Achilleas, additional, Li-Gao, Ruifang, additional, Hang, Kei, additional, Yao, Jie, additional, Anasanti, Mila D, additional, Chu, Audrey Y, additional, Claringbould, Annique, additional, Heikkinen, Jani, additional, Hong, Jaeyoung, additional, Hottenga, Jouke-Jan, additional, Huo, Shaofeng, additional, Kaakinen, Marika A., additional, Louie, Tin, additional, März, Winfried, additional, Moreno-Macias, Hortensia, additional, Ndungu, Anne, additional, Nelson, Sarah C., additional, Nolte, Ilja M., additional, North, Kari, additional, Raulerson, Chelsea K., additional, Ray, Debashree, additional, Rohde, Rebecca, additional, Rybin, Denis, additional, Schurmann, Claudia, additional, Sim, Xueling, additional, Southam, Loz, additional, Stewart, Isobel, additional, Wang, Carol A., additional, Wang, Yujie, additional, Wu, Peitao, additional, Zhang, Weihua, additional, Ahluwalia, Tarunveer S., additional, Appel, Emil VR, additional, Bielak, Lawrence F., additional, Brody, Jennifer A., additional, Burtt, Noel P, additional, Cabrera, Claudia P, additional, Cade, Brian E, additional, Chai, Jin Fang, additional, Chai, Xiaoran, additional, Chang, Li-Ching, additional, Chen, Chien-Hsiun, additional, Chen, Brian H, additional, Chitrala, Kumaraswamy N, additional, Chiu, Yen-Feng, additional, de Haan, Hugoline G., additional, Delgado, Graciela E, additional, Demirkan, Ayse, additional, Duan, Qing, additional, Engmann, Jorgen, additional, Fatumo, Segun A, additional, Gayán, Javier, additional, Giulianini, Franco, additional, Gong, Jung Ho, additional, Gustafsson, Stefan, additional, Hai, Yang, additional, Hartwig, Fernando P, additional, He, Jing, additional, Heianza, Yoriko, additional, Huang, Tao, additional, Huerta-Chagoya, Alicia, additional, Hwang, Mi Yeong, additional, Jensen, Richard A., additional, Kawaguchi, Takahisa, additional, Kentistou, Katherine A, additional, Kim, Young Jin, additional, Kleber, Marcus E, additional, Kooner, Ishminder K, additional, Lai, Shuiqing, additional, Lange, Leslie A, additional, Langefeld, Carl D, additional, Lauzon, Marie, additional, Li, Man, additional, Ligthart, Symen, additional, Liu, Jun, additional, Loh, Marie, additional, Long, Jirong, additional, Lyssenko, Valeriya, additional, Mangino, Massimo, additional, Marzi, Carola, additional, Montasser, May E, additional, Nag, Abhishek, additional, Nakatochi, Masahiro, additional, Noce, Damia, additional, Noordam, Raymond, additional, Pistis, Giorgio, additional, Preuss, Michael, additional, Raffield, Laura, additional, Rasmussen-Torvik, Laura J., additional, Rich, Stephen S, additional, Robertson, Neil R, additional, Rueedi, Rico, additional, Ryan, Kathleen, additional, Sanna, Serena, additional, Saxena, Richa, additional, Schraut, Katharina E, additional, Sennblad, Bengt, additional, Setoh, Kazuya, additional, Smith, Albert V, additional, Southam, Lorraine, additional, Sparsø, Thomas, additional, Strawbridge, Rona J, additional, Takeuchi, Fumihiko, additional, Tan, Jingyi, additional, Trompet, Stella, additional, van den Akker, Erik, additional, Van der Most, Peter J, additional, Verweij, Niek, additional, Vogel, Mandy, additional, Wang, Heming, additional, Wang, Chaolong, additional, Wang, Nan, additional, Warren, Helen R, additional, Wen, Wanqing, additional, Wilsgaard, Tom, additional, Wong, Andrew, additional, Wood, Andrew R, additional, Xie, Tian, additional, Zafarmand, Mohammad Hadi, additional, Zhao, Jing-Hua, additional, Zhao, Wei, additional, Amin, Najaf, additional, Arzumanyan, Zorayr, additional, Astrup, Arne, additional, Bakker, Stephan JL, additional, Baldassarre, Damiano, additional, Beekman, Marian, additional, Bergman, Richard N, additional, Bertoni, Alain, additional, Blüher, Matthias, additional, Bonnycastle, Lori L., additional, Bornstein, Stefan R, additional, Bowden, Donald W, additional, Cai, Qiuyin, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chang, Yi Cheng, additional, de Geus, Eco J.C., additional, Dehghan, Abbas, additional, Du, Shufa, additional, Eiriksdottir, Gudny, additional, Farmaki, Aliki Eleni, additional, Frånberg, Mattias, additional, Fuchsberger, Christian, additional, Gao, Yutang, additional, Gjesing, Anette P, additional, Goel, Anuj, additional, Han, Sohee, additional, Hartman, Catharina A, additional, Herder, Christian, additional, Hicks, Andrew A., additional, Hsieh, Chang-Hsun, additional, Hsueh, Willa A., additional, Ichihara, Sahoko, additional, Igase, Michiya, additional, Ikram, M. Arfan, additional, Johnson, W. Craig, additional, Jørgensen, Marit E, additional, Joshi, Peter K, additional, Kalyani, Rita R, additional, Kandeel, Fouad R., additional, Katsuya, Tomohiro, additional, Khor, Chiea Chuen, additional, Kiess, Wieland, additional, Kolcic, Ivana, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Läll, Kristi, additional, Lam, Kelvin, additional, Lawlor, Deborah A, additional, Lee, Nanette R., additional, Lemaitre, Rozenn N., additional, Li, Honglan, additional, Study, Lifelines Cohort, additional, Lin, Shih-Yi, additional, Lindström, Jaana, additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Lorenzo, Carlos, additional, Matsubara, Tatsuaki, additional, Matsuda, Fumihiko, additional, Mingrone, Geltrude, additional, Mooijaart, Simon, additional, Moon, Sanghoon, additional, Nabika, Toru, additional, Nadkarni, Girish N., additional, Nadler, Jerry L., additional, Nelis, Mari, additional, Neville, Matthew J, additional, Norris, Jill M, additional, Ohyagi, Yasumasa, additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Qi, Qibin, additional, Raven, Dennis, additional, Reilly, Dermot F, additional, Reiner, Alex, additional, Rivideneira, Fernando, additional, Roll, Kathryn, additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Sandow, Kevin, additional, Sattar, Naveed, additional, Schürmann, Annette, additional, Shi, Jinxiu, additional, Stringham, Heather M, additional, Taylor, Kent D., additional, Teslovich, Tanya M., additional, Thuesen, Betina, additional, Timmers, Paul RHJ, additional, Tremoli, Elena, additional, Tsai, Michael Y, additional, Uitterlinden, Andre, additional, van Dam, Rob M, additional, van Heemst, Diana, additional, van Hylckama Vlieg, Astrid, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Wang, Tao, additional, van Dijk, Ko Willems, additional, Xiang, Yongbing, additional, Zemunik, Tatijana, additional, Abecasis, Goncalo R, additional, Adair, Linda S., additional, Aguilar-Salinas, Carlos Alberto, additional, Alarcón-Riquelme, Marta E, additional, An, Ping, additional, Aviles-Santa, Larissa, additional, Becker, Diane M, additional, Beilin, Lawrence J, additional, Bergmann, Sven, additional, Bisgaard, Hans, additional, Black, Corri, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Böhm, Bernhard O, additional, Bønnelykke, Klaus, additional, Boomsma, D I., additional, Bottinger, Erwin P., additional, Buchanan, Thomas A, additional, Canouil, Mickaël, additional, Caulfield, Mark J, additional, Chambers, John C., additional, Chasman, Daniel I., additional, Chen, Yii-Der Ida, additional, Cheng, Ching-Yu, additional, Collins, Francis S., additional, Correa, Adolfo, additional, Cucca, Francesco, additional, de Silva, H. Janaka, additional, Dedoussis, George, additional, Elmståhl, Sölve, additional, Evans, Michele K., additional, Ferranni, Ele, additional, Ferruci, Luigi, additional, Florez, Jose C, additional, Franks, Paul, additional, Frayling, Timothy M, additional, Froguel, Philippe, additional, Gigante, Bruna, additional, Goodarzi, Mark O., additional, Gordon-Larsen, Penny, additional, Grallert, Harald, additional, Grarup, Niels, additional, Grimsgaard, Sameline, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Horta, Bernardo L, additional, Huang, Wei, additional, Ingelsson, Erik, additional, James, Pankow S, additional, Jonas, Jost B, additional, Jukema, J. Wouter, additional, Kaleebu, Pontiano, additional, Kaplan, Robert, additional, Kardia, Sharon L.R., additional, Kato, Norihiro, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kim, Bong-Jo, additional, Kivimaki, Mika, additional, Koistinen, Heikki A., additional, Kooner, Jaspal S., additional, Körner, Antje, additional, Kovacs, Peter, additional, Kuh, Diana, additional, Kumari, Meena, additional, Kutalik, Zoltan, additional, Laakso, Markku, additional, Lakka, Timo A., additional, Launer, Lenore J, additional, Leander, Karin, additional, Li, Huaixing, additional, Lin, Xu, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Simin, additional, Loos, Ruth J.F., additional, Magnusson, Patrik, additional, Mahajan, Anubha, additional, Metspalu, Andres, additional, Mook-Kanamori, Dennis O, additional, Mori, Trevor A, additional, Munroe, Patricia B, additional, Njølstad, Inger, additional, O’Connell, Jeffrey R, additional, Oldehinkel, Albertine J, additional, Ong, Ken K, additional, Padmanabhan, Sandosh, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D, additional, Pedersen, Oluf, additional, Pennell, Craig E, additional, Porteous, David J, additional, Pramstaller, Peter P., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Raffel, Leslie J., additional, Rauramaa, Rainer, additional, Redline, Susan, additional, Ridker, Paul M, additional, Rosendaal, Frits R., additional, Saaristo, Timo E., additional, Sandhu, Manjinder, additional, Saramies, Jouko, additional, Schneiderman, Neil, additional, Schwarz, Peter, additional, Scott, Laura J., additional, Selvin, Elizabeth, additional, Sever, Peter, additional, Shu, Xiao-ou, additional, Slagboom, P Eline, additional, Small, Kerrin S, additional, Smith, Blair H, additional, Snieder, Harold, additional, Sofer, Tamar, additional, Sørensen, Thorkild I.A., additional, Spector, Tim D, additional, Stanton, Alice, additional, Steves, Claire J, additional, Stumvoll, Michael, additional, Sun, Liang, additional, Tabara, Yasuharu, additional, Tai, E Shyong, additional, Timpson, Nicholas J, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Tusie, Teresa, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, van Duijn, Cornelia, additional, Vitart, Veronique, additional, Vollenweider, Peter, additional, Vrijkotte, Tanja GM, additional, Wagenknecht, Lynne E, additional, Walker, Mark, additional, Wang, Ya X, additional, Wareham, Nick J, additional, Watanabe, Richard M, additional, Watkins, Hugh, additional, Wei, Wen B, additional, Wickremasinghe, Ananda R, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wong, Tien-Yin, additional, Wu, Jer-Yuarn, additional, Xiang, Anny H, additional, Yanek, Lisa R, additional, Yengo, Loïc, additional, Yokota, Mitsuhiro, additional, Zeggini, Eleftheria, additional, Zheng, Wei, additional, Zonderman, Alan B, additional, Rotter, Jerome I, additional, Gloyn, Anna L, additional, McCarthy, Mark I., additional, Dupuis, Josée, additional, Meigs, James B, additional, Scott, Robert, additional, Prokopenko, Inga, additional, Leong, Aaron, additional, Liu, Ching-Ti, additional, Parker, Stephen CJ, additional, Mohlke, Karen L., additional, Langenberg, Claudia, additional, Wheeler, Eleanor, additional, Morris, Andrew P., additional, and Barroso, Inês, additional
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- 2020
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159. Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling
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Aliwarga, Theresa, primary, Guo, Xiaoyun, additional, Evangelista, Eric A., additional, Lemaitre, Rozenn N., additional, Sotoodehnia, Nona, additional, Gharib, Sina A., additional, Zeldin, Darryl C., additional, Liu, Qinghang, additional, and Totah, Rheem A., additional
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- 2020
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160. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
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Zheng, Yan, primary, Huang, Tao, additional, Wang, Tiange, additional, Mei, Zhendong, additional, Sun, Zhonghan, additional, Zhang, Tao, additional, Ellervik, Christina, additional, Chai, Jin-Fang, additional, Sim, Xueling, additional, van Dam, Rob M., additional, Tai, E-Shyong, additional, Koh, Woon-Puay, additional, Dorajoo, Rajkumar, additional, Saw, Seang-Mei, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Gupta, Preeti, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Wang, Yujie, additional, Graff, Mariaelisa, additional, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Hofman, Albert, additional, van Heemst, Diana, additional, Noordam, Raymond, additional, Estampador, Angela C., additional, Varga, Tibor V., additional, Enzenbach, Cornelia, additional, Scholz, Markus, additional, Thiery, Joachim, additional, Burkhardt, Ralph, additional, Orho-Melander, Marju, additional, Schulz, Christina-Alexandra, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Kubo, Michiaki, additional, Akiyama, Masato, additional, Zhou, Ang, additional, Kilpeläinen, Tuomas O., additional, Hansen, Torben, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, McCarthy, Mark, additional, Lemaitre, Rozenn N., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Wu, Ying, additional, Mohlke, Karen L., additional, Lehtimäki, Terho, additional, Wang, Carol A., additional, Pennell, Craig E., additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Willenborg, Christina, additional, Peters, Annette, additional, Lieb, Wolfgang, additional, Grote, Veit, additional, Rzehak, Peter, additional, Koletzko, Berthold, additional, Erdmann, Jeanette, additional, Munz, Matthias, additional, Wu, Tangchun, additional, He, Meian, additional, Yu, Caizheng, additional, Lecoeur, Cécile, additional, Froguel, Philippe, additional, Corella, Dolores, additional, Moreno, Luis A., additional, Lai, Chao-Qiang, additional, Pitkänen, Niina, additional, Boreham, Colin A., additional, Ridker, Paul M., additional, Rosendaal, Frits R., additional, de Mutsert, Renée, additional, Power, Chris, additional, Paternoster, Lavinia, additional, Sørensen, Thorkild I. A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Djousse, Luc, additional, Rivadeneira, Fernando, additional, Lee, Nanette R., additional, Raitakari, Olli T., additional, Kähönen, Mika, additional, Viikari, Jorma, additional, Langhendries, Jean-Paul, additional, Escribano, Joaquin, additional, Verduci, Elvira, additional, Dedoussis, George, additional, König, Inke, additional, Balkau, Beverley, additional, Coltell, Oscar, additional, Dallongeville, Jean, additional, Meirhaeghe, Aline, additional, Amouyel, Philippe, additional, Gottrand, Frédéric, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Hyppönen, Elina, additional, März, Winfried, additional, Mackey, David A., additional, Gruszfeld, Dariusz, additional, Tucker, Katherine L., additional, Fumeron, Frédéric, additional, Estruch, Ramon, additional, Ordovas, Jose M., additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, North, Kari E., additional, Chasman, Daniel I., additional, and Qi, Lu, additional
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- 2020
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161. Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study
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Fretts, Amanda M, primary, Jensen, Paul N, additional, Hoofnagle, Andrew, additional, McKnight, Barbara, additional, Howard, Barbara V, additional, Umans, Jason, additional, Yu, Chaoyu, additional, Sitlani, Colleen, additional, Siscovick, David S, additional, King, Irena B, additional, Sotoodehnia, Nona, additional, and Lemaitre, Rozenn N, additional
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- 2020
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162. Serial Biomarkers of De Novo Lipogenesis Fatty Acids and Incident Heart Failure in Older Adults: The Cardiovascular Health Study
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Lee, Yujin, primary, Lai, Heidi T. M., additional, de Oliveira Otto, Marcia C., additional, Lemaitre, Rozenn N., additional, McKnight, Barbara, additional, King, Irena B., additional, Song, Xiaoling, additional, Huggins, Gordon S., additional, Vest, Amanda R., additional, Siscovick, David S., additional, and Mozaffarian, Dariush, additional
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- 2020
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163. Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study
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Jensen, Paul N., primary, Fretts, Amanda M., additional, Hoofnagle, Andrew N., additional, Sitlani, Colleen M., additional, McKnight, Barbara, additional, King, Irena B., additional, Siscovick, David S., additional, Psaty, Bruce M., additional, Heckbert, Susan R., additional, Mozaffarian, Dariush, additional, Sotoodehnia, Nona, additional, and Lemaitre, Rozenn N., additional
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- 2020
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164. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults: A Cohort Study
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Mozaffarian, Dariush, Cao, Haiming, King, Irena B., Lemaitre, Rozenn N., Song, Xiaoling, Siscovick, David S., and Hotamisligil, Gökhan S.
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- 2010
165. Interactions of Dietary Whole-Grain Intake With Fasting Glucose– and Insulin-Related Genetic Loci in Individuals of European Descent: A meta-analysis of 14 cohort studies
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Nettleton, Jennifer A., McKeown, Nicola M., Kanoni, Stavroula, Lemaitre, Rozenn N., Hivert, Marie-France, Ngwa, Julius, van Rooij, Frank J.A., Sonestedt, Emily, Wojczynski, Mary K., Ye, Zheng, and Tanaka, Tosh
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- 2010
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166. Associations of diet quality and blood serum lipoprotein levels in a population at high risk for diabetes: the Strong Heart Family Study
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Kauffman, Sophie A. E., primary, Averill, Michelle M., additional, Delaney, Joseph A. C, additional, Lemaitre, Rozenn N., additional, Howard, Barbara V., additional, and Fretts, Amanda M., additional
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- 2019
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167. Trans-palmitoleic acid, metabolic risk factors, and new-0nset diabetes in U.S. adults: a cohort study
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Mozaffarian, Dariush, Cao, Haiming, King, Irena B., Lemaitre, Rozenn N., Song, Xiaoling, Siscovick, David S., and Hotamisligil, Gokhan S.
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Monounsaturated fatty acids -- Physiological aspects ,Monounsaturated fatty acids -- Genetic aspects ,Monounsaturated fatty acids -- Research ,Type 2 diabetes -- Risk factors ,Type 2 diabetes -- Care and treatment ,Type 2 diabetes -- Research ,Health - Abstract
Background: Palmitoleic acid (cis-16:1n-7), which is produced by endogenous fat synthesis, has been linked to both beneficial and deleterious metabolic effects, potentially confounded by diverse determinants and tissue sources of endogenous production. Transpalmitoleate (trans-16:1n-7) represents a distinctly exogenous source of 16:1n-7, unconfounded by endogenous synthesis or its determinants, that may be uniquely informative. Objective: To investigate whether circulating trans-palmitoleate is independently related to lower metabolic risk and incident type 2 diabetes. Design: Prospective cohort study from 1992 to 2006. Setting: Four U.S. communities. Patients: 3736 adults in the Cardiovascular Health Study. Measurements: Anthropometric characteristics and levels of plasma phospholipid fatty acids, blood lipids, inflammatory markers, and glucose-insulin measured at baseline in 1992 and dietary habits measured 3 years earlier. Multivariate-adjusted models were used to investigate how demographic, clinical, and lifestyle factors independently related to plasma phospholipid trans-palmitoleate; how trans-palmitoleate related to major metabolic risk factors; and how trans-palmitoleate related to new-onset diabetes (304 incident cases). Findings were validated for metabolic risk factors in an independent cohort of 327 women. Results: In multivariate analyses, whole-fat dairy consumption was most strongly associated with higher trans-palmitoleate levels. Higher trans-palmitoleate levels were associated with slightly lower adiposity and, independently, with higher high-density lipoprotein cholesterol levels (1.9% across quintiles; P = 0.040), lower triglyceride levels (-19.0%; P < 0.001), a lower total cholesterol-HDL cholesterol ratio (-4.7%; P < 0.001), lower C-reactive protein levels (-13.8%; P= 0.05), and lower insulin resistance (-16.7%, P < 0.001). Trans-palmitoleate was also associated with a substantially lower incidence of diabetes, with multivariate hazard ratios of 0.41 (95% CI, 0.27 to 0.64) and 0.38 (CI, 0.24 to 0.62) in quintiles 4 and 5 versus quintile 1 (P for trend < 0.001). Findings were independent of estimated dairy consumption or other fatty acid dairy biomarkers. Protective associations with metabolic risk factors were confirmed in the validation cohort. Limitation: Results could be affected by measurement error or residual confounding. Conclusion: Circulating trans-palmitoleate is associated with lower insulin resistance, presence of atherogenic dyslipidemia, and incident diabetes. Our findings may explain previously observed metabolic benefits of dairy consumption and support the need for detailed further experimental and clinical investigation. Primary Funding Source: National Heart, Lung, and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.
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- 2010
168. Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
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Mozaffarian, Dariush, Cao, Haiming, King, Irena B., Lemaitre, Rozenn N., Song, Xiaoling, Siscovick, David S., and Hotamisligil, Gokhan S.
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Insulin resistance -- Research ,Metabolic diseases -- Risk factors ,Metabolic diseases -- Research ,Diabetes -- Research ,Diabetes -- Analysis ,Food/cooking/nutrition ,Health - Abstract
Background: Animal experiments suggest that circulating palmitoleic acid (cis-16:ln-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance and metabolic dysregulation. Objective: We investigated the independent determinants of circulating palmitoleate in free-living humans and whether palmitoleate is related to lower metabolic risk and the incidence of diabetes. Design: In a prospective cohort of 3630 US men and women in the Cardiovascular Health Study, plasma phospholipid fatty acids, anthropometric variables, blood lipids, inflammatory markers, and glucose and insulin concentrations were measured between 1992 and 2006 by using standardized methods. Independent determinants of plasma phospholipid palmitoleate and relations of palmitoleate with metabolic risk factors were investigated by using multivariable-adjusted linear regression. Relations with incident diabetes (296 incident cases) were investigated by using Cox proportional hazards. Results: The mean ([+ or -]SD) palmitoleate value was 0.49 [+ or -] 0.20% (range: 0.11-2.55%) of total fatty acids. Greater body mass index, carbohydrate intake, protein intake, and alcohol use were each independent lifestyle correlates of higher palmitoleate concentrations. In multivariable analyses that adjusted for these factors and other potential confounders, higher palmitoleate concentrations were independently associated with lower LDL cholesterol (P < 0.001), higher HDL cholesterol (P < 0.001), lower total:HDL-cholesterol ratio (P = 0.04), and lower fibrinogen (P < 0.001). However, palmitoleate was also associated with higher triglycerides (P < 0.001) and (in men only) with greater insulin resistance (P < 0.001). Palmitoleate was not significantly associated with incident diabetes. Conclusions: Adiposity (energy imbalance), carbohydrate consumption, and alcohol use--even within typical ranges--are associated with higher circulating palmitoleate concentrations. Circulating palmitoleate is robustly associated with multiple metabolic risk factors but in mixed directions, perhaps related to divergent lifestyle determinants or endogenous sources (liver, adipose tissue) of fatty acid synthesis. Am J Clin Nutr 2010;92: 1350-8. doi: 10.3945/ajcn.110.003970.
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- 2010
169. Very long-chain saturated fatty acids and diabetes and cardiovascular disease.
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Lemaitre, Rozenn N. and King, Irena B.
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- 2022
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170. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies
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Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason HY, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, InterAct Consortium, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N, Imamura, Fumiaki [0000-0002-6841-8396], Forouhi, Nita [0000-0002-5041-248X], Wareham, Nicholas [0000-0003-1422-2993], Koulman, Albert [0000-0001-9998-051X], and Apollo - University of Cambridge Repository
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Adult ,Aged, 80 and over ,Male ,Fatty Acids and Outcomes Research Consortium ,diabetes ,Fatty Acids ,Middle Aged ,very-long-chain saturated fatty acids ,meta-analysis ,Diabetes Mellitus, Type 2 ,Eicosanoic Acids ,Cohorts for Heart and Aging Research in Genomic Epidemiology ,Humans ,saturated fatty acids ,Female ,Prospective Studies ,Aged - Abstract
BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
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- 2019
171. Association of Genetic Variations With Nonfatal Venous Thrombosis in Postmenopausal Women
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Smith, Nicholas L., Hindorff, Lucia A., Heckbert, Susan R., Lemaitre, Rozenn N., Marciante, Kristin D., Rice, Kenneth, Lumley, Thomas, Bis, Joshua C., Wiggins, Kerri L., Rosendaal, Frits R., and Psaty, Bruce M.
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- 2007
172. Common Genetic Variation in the Prothrombin Gene, Hormone Therapy, and Incident Nonfatal Myocardial Infarction in Postmenopausal Women
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Hindorff, Lucia A., Psaty, Bruce M., Carlson, Christopher S., Heckbert, Susan R., Lumley, Thomas, Smith, Nicholas L., Lemaitre, Rozenn N., Rieder, Mark J., Nickerson, Deborah A., and Reiner, Alexander P.
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- 2006
173. Esterified Estrogen and Conjugated Equine Estrogen and the Risk of Incident Myocardial Infarction and Stroke
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Lemaitre, Rozenn N., Weiss, Noel S., Smith, Nicholas L., Psaty, Bruce M., Lumley, Thomas, Larson, Eric B., and Heckbert, Susan R.
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- 2006
174. Health outcomes associated with antihypertensive therapies used as first-line agents: a systematic review and meta-analysis
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Psaty, Bruce M., Smith, Nicholas L., Siscovick, David S., Koepsell, Thomas D., Weiss, Noel S., Heckbert, Susan R., Lemaitre, Rozenn N., Wagner, Edward H., and Furberg, Curt D.
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Antihypertensive drugs -- Evaluation ,Hypertension -- Drug therapy ,Diuretics -- Evaluation ,Adrenergic beta blockers -- Evaluation ,ACE inhibitors -- Evaluation ,Calcium channel blockers -- Evaluation - Abstract
Diuretics and beta blockers remain the treatment of choice for hypertension. Researchers reviewed all of the long-term clinical trials of antihypertensive drugs, including beta blockers, diuretics, ACE inhibitors and calcium channel blockers. There is strong evidence that diuretics and beta blockers can reduce the risk of stroke and heart failure, which are the major complications of chronic hypertension. There is much less evidence that ACE inhibitors and calcium channel blockers are effective, except in speciific patient groups such as those with coronary artery disease and congestive heart failure., Objective.--To review the scientific evidence concerning the safety and efficacy of various antihypertensive therapies used as first-line agents and evaluated in terms of major disease end points. Data Sources.--MEDLINE searches and previous meta-analyses for 1980 to 1995. Data Selection.--We selected long-term studies that assessed major disease end points as an outcome. For the meta-analysis, we chose placebo-controlled randomized trials. For randomized trials using surrogate end points such as blood pressure, we selected the largest studies that evaluated multiple drugs. Where clinical trial evidence was lacking, we relied on information from observational studies. Data Synthesis.--Diuretics and [Beta]-blockers have been evaluated in 18 long-term randomized trials. Compared with placebo, [Beta]-blocker therapy was effective in preventing stroke (relative risk [RR], 0.71; 95% confidence interval [CI], 0.59-0.86) and congestive heart failure (RR, 0.58; 95% CI, 0.40-0.84). The findings were similar for high-dose diuretic therapy (for stroke, RR, 0.49; 95% CI, 0.39-0.62; and for congestive heart failure, RR, 0.17; 95% CI, 0.07-0.41). Low-dose diuretic therapy prevented not only stroke (RR, 0.66; 95% CI, 0.55-0.78) and congestive heart failure (RR, 0.58; 95% CI, 0.44-0.76) but also coronary disease (RR, 0.72; 95% CI, 0.61-0.85) and total mortality (RR, 0.90; 95% CI, 0.81-0.99). Although calcium channel blockers and angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure in hypertensive patients, the clinical trial evidence in terms of health outcomes is meager. For several short-acting dihydropyridine calcium channel blockers, the available evidence suggests the possibility of harm. Whether the long-acting formulations and the nondihydropyridine calcium channel blockers are safe and prevent major cardiovascular events in patients with hypertension remains untested and therefore unknown. Conclusion.--Until the results of large long-term clinical trials evaluating the effects of calcium channel blockers and ACE inhibitors on cardiovascular disease incidence are completed, the available scientific evidence provides strong support for the current national guidelines, which recommend diuretics and [Beta]-blockers as first-line agents and low-dose therapy for all antihypertensive agents. JAMA. 1997;277:789-745
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- 1997
175. Fish Consumption and Stroke Risk in Elderly Individuals: The Cardiovascular Health Study
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Mozaffarian, Dariush, Longstreth, W. T., Jr, Lemaitre, Rozenn N., Manolio, Teri A., Kuller, Lewis H., Burke, Gregory L., and Siscovick, David S.
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- 2005
176. Incidence of Out-of-Hospital cardiac arrest
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Rea, Thomas D, Pearce, Rachel M, Raghunathan, Trivellore E, Lemaitre, Rozenn N, Sotoodehnia, Nona, Jouven, Xavier, and Siscovick, David S
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- 2004
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177. Quality of dietary fat and genetic risk of type 2 diabetes:individual participant data meta-analysis
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Merino, Jordi, Guasch-Ferré, Marta, Ellervik, Christina, Dashti, Hassan S, Sharp, Stephen J, Wu, Peitao, Overvad, Kim, Sarnowski, Chloé, Kuokkanen, Mikko, Lemaitre, Rozenn N, Justice, Anne E, Ericson, Ulrika, Braun, Kim V E, Mahendran, Yuvaraj, Frazier-Wood, Alexis C, Sun, Dianjianyi, Chu, Audrey Y, Tanaka, Toshiko, Luan, Jian'an, Hong, Jaeyoung, Tjønneland, Anne, Ding, Ming, Lundqvist, Annamari, Mukamal, Kenneth, Rohde, Rebecca, Schulz, Christina-Alexandra, Franco, Oscar H, Grarup, Niels, Chen, Yii-Der Ida, Bazzano, Lydia, Franks, Paul W, Buring, Julie E, Langenberg, Claudia, Liu, Ching-Ti, Hansen, Torben, Jensen, Majken K, Sääksjärvi, Katri, Psaty, Bruce M, Young, Kristin L, Hindy, George, Sandholt, Camilla Helene, Ridker, Paul M, Ordovas, Jose M, Meigs, James B, Pedersen, Oluf, Kraft, Peter, Perola, Markus, North, Kari E, Orho-Melander, Marju, Voortman, Trudy, Toft, Ulla, Rotter, Jerome I, Qi, Lu, Forouhi, Nita G, Mozaffarian, Dariush, Sørensen, Thorkild I A, Stampfer, Meir J, Männistö, Satu, Selvin, Elizabeth, Imamura, Fumiaki, Salomaa, Veikko, Hu, Frank B, Wareham, Nick J, Dupuis, Josée, Smith, Caren E, Kilpeläinen, Tuomas O, Chasman, Daniel I, Florez, Jose C, Merino, Jordi, Guasch-Ferré, Marta, Ellervik, Christina, Dashti, Hassan S, Sharp, Stephen J, Wu, Peitao, Overvad, Kim, Sarnowski, Chloé, Kuokkanen, Mikko, Lemaitre, Rozenn N, Justice, Anne E, Ericson, Ulrika, Braun, Kim V E, Mahendran, Yuvaraj, Frazier-Wood, Alexis C, Sun, Dianjianyi, Chu, Audrey Y, Tanaka, Toshiko, Luan, Jian'an, Hong, Jaeyoung, Tjønneland, Anne, Ding, Ming, Lundqvist, Annamari, Mukamal, Kenneth, Rohde, Rebecca, Schulz, Christina-Alexandra, Franco, Oscar H, Grarup, Niels, Chen, Yii-Der Ida, Bazzano, Lydia, Franks, Paul W, Buring, Julie E, Langenberg, Claudia, Liu, Ching-Ti, Hansen, Torben, Jensen, Majken K, Sääksjärvi, Katri, Psaty, Bruce M, Young, Kristin L, Hindy, George, Sandholt, Camilla Helene, Ridker, Paul M, Ordovas, Jose M, Meigs, James B, Pedersen, Oluf, Kraft, Peter, Perola, Markus, North, Kari E, Orho-Melander, Marju, Voortman, Trudy, Toft, Ulla, Rotter, Jerome I, Qi, Lu, Forouhi, Nita G, Mozaffarian, Dariush, Sørensen, Thorkild I A, Stampfer, Meir J, Männistö, Satu, Selvin, Elizabeth, Imamura, Fumiaki, Salomaa, Veikko, Hu, Frank B, Wareham, Nick J, Dupuis, Josée, Smith, Caren E, Kilpeläinen, Tuomas O, Chasman, Daniel I, and Florez, Jose C
- Abstract
OBJECTIVE: To investigate whether the genetic burden of type 2 diabetes modifies the association between the quality of dietary fat and the incidence of type 2 diabetes.DESIGN: Individual participant data meta-analysis.DATA SOURCES: Eligible prospective cohort studies were systematically sourced from studies published between January 1970 and February 2017 through electronic searches in major medical databases (Medline, Embase, and Scopus) and discussion with investigators.REVIEW METHODS: Data from cohort studies or multicohort consortia with available genome-wide genetic data and information about the quality of dietary fat and the incidence of type 2 diabetes in participants of European descent was sought. Prospective cohorts that had accrued five or more years of follow-up were included. The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes. Diet was recorded by using validated cohort-specific dietary assessment tools. Outcome measures were summary adjusted hazard ratios of incident type 2 diabetes for polygenic risk score, isocaloric replacement of carbohydrate (refined starch and sugars) with types of fat, and the interaction of types of fat with polygenic risk score.RESULTS: Of 102 305 participants from 15 prospective cohort studies, 20 015 type 2 diabetes cases were documented after a median follow-up of 12 years (interquartile range 9.4-14.2). The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I2=7.1%, τ2=0.003). The increase of polyunsaturated fat and total omega 6 polyunsaturated fat intake in place of carbohydrate was associated with a lower risk of type 2 diabetes, with hazard ratios of 0.90 (0.82 to 0.98, I2=18.0%, τ2=0.006; per 5% of energy) and 0.99 (0.97 to 1.00, I2=58.8%, τ2=0.001; per increment of 1 g/d), respectively. Increasing monounsaturated fat
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- 2019
178. Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation
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Dörr, Marcus, Hamburg, Naomi M., Müller, Christian, Smith, Nicholas L., Gustafsson, Stefan, Lehtimäki, Terho, Teumer, Alexander, Zeller, Tanja, Li, Xiaohui, Lind, Lars, Raitakari, Olli T., Völker, Uwe, Blankenberg, Stefan, McKnight, Barbara, Morris, Andrew P., Kähönen, Mika, Lemaitre, Rozenn N., Wild, Philipp S., Nauck, Matthias, Völzke, Henry, Münzel, Thomas, Mitchell, Gary F., Psaty, Bruce M., Lindgren, Cecilia M., Larson, Martin G., Felix, Stephan B., Ingelsson, Erik, Lyytikaeinen, Leo-Pekka, Herrington, David, Benjamin, Emelia J., Schnabel, Renate B., Dörr, Marcus, Hamburg, Naomi M., Müller, Christian, Smith, Nicholas L., Gustafsson, Stefan, Lehtimäki, Terho, Teumer, Alexander, Zeller, Tanja, Li, Xiaohui, Lind, Lars, Raitakari, Olli T., Völker, Uwe, Blankenberg, Stefan, McKnight, Barbara, Morris, Andrew P., Kähönen, Mika, Lemaitre, Rozenn N., Wild, Philipp S., Nauck, Matthias, Völzke, Henry, Münzel, Thomas, Mitchell, Gary F., Psaty, Bruce M., Lindgren, Cecilia M., Larson, Martin G., Felix, Stephan B., Ingelsson, Erik, Lyytikaeinen, Leo-Pekka, Herrington, David, Benjamin, Emelia J., and Schnabel, Renate B.
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- 2019
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179. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes : a pooled analysis of prospective cohort studies
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Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N., Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, and Lemaitre, Rozenn N.
- Abstract
Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Methods: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
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- 2019
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180. Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
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de Vries, Paul S., Brown, Michael R., Bentley, Amy R., Sung, Yun J., Winkler, Thomas W., Ntalla, Ioanna, Schwander, Karen, Kraja, Aldi T., Guo, Xiuqing, Franceschini, Nora, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E., Musani, Solomon K., Li, Changwei, Feitosa, Mary F., Richard, Melissa A., Noordam, Raymond, Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Deng, Xuan, Dorajoo, Rajkumar, Lohman, Kurt K., Manning, Alisa K., Rankinen, Tuomo, Smith, Albert V., Tajuddin, Salman M., Evangelou, Evangelos, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E., Hartwig, Fernando P., He, Meian, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Laguzzi, Federica, Lee, Joseph H., Luan, Jian'an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M., Pietzner, Maik, Riaz, Muhammad, Said, M. Abdullah, Scott, Robert A., Sofer, Tamar, Stancakova, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O., van der Most, Peter J., Varga, Tibor V., Wang, Yajuan, Ware, Erin B., Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E., Aung, Tin, Ballantyne, Christie, Boerwinkle, Eric, Broeckel, Ulrich, Campbell, Archie, Canouil, Mickael, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Connell, John M., de Faire, Ulf, de las Fuentes, Lisa, de Mutsert, Renee, de Silva, H. Janaka, Ding, Jingzhong, Dominiczak, Anna F., Duan, Qing, Eaton, Charles B., Eppinga, Ruben N., Faul, Jessica D., Fisher, Virginia, Forrester, Terrence, Franco, Oscar H., Friedlander, Yechiel, Ghanbari, Mohsen, Giulianini, Franco, Grabe, Hans J., Grove, Megan L., Gu, C. Charles, Harris, Tamara B., Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hixson, James E., Howard, Barbara V., Ikram, M. Arfan, Jacobs, David R., Jr., Johnson, Craig, Jonas, Jost Bruno, Kammerer, Candace M., Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpelainen, Tuomas O., Koh, Woon-Puay, Koistinen, Heikki A., Kolcic, Ivana, Kooperberg, Charles, Krieger, Jose E., Kritchevsky, Steve B., Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lehne, Benjamin, Lemaitre, Rozenn N., Li, Yize, Liang, Jingjing, Liu, Jianjun, Liu, Kiang, Loh, Marie, Louie, Tin, Magi, Reedik, Manichaikul, Ani W., McKenzie, Colin A., Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L., Mosley, Thomas H., Jr., Mukamal, Kenneth J., Nalls, Mike A., Nauck, Matthias, Nelson, Christopher P., Sotoodehnia, Nona, O'Connell, Jeff R., Palmer, Nicholette D., Pazoki, Raha, Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Poulter, Neil, Raffel, Leslie J., Raitakari, Olli T., Reiner, Alex P., Rice, Treva K., Rich, Stephen S., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Sever, Peter, Shi, Yuan, Sidney, Stephen, Sims, Mario, Smith, Blair H., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tan, Nicholas, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Uitterlinden, Andre G., van Heemst, Diana, Vuckovic, Dragana, Waldenberger, Melanie, Wang, Lihua, Wang, Yujie, Wang, Zhe, Wei, Wen Bin, Williams, Christine, Wilson, Gregory, Sr., Wojczynski, Mary K., Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Deary, Ian J., Esko, Tonu, Farrall, Martin, Franks, Paul W., Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo L., Kamatani, Yoichiro, Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Leander, Karin, Lehtimaki, Terho, Magnusson, Patrik K. E., Penninx, Brenda, Pereira, Alexandre C., Rauramaa, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E., Wang, Ya Xing, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wickremasinghe, Ananda R., Zheng, Wei, Elliott, Paul, North, Kari E., Bouchard, Claude, Evans, Michele K., Gudnason, Vilmundur, Liu, Ching-Ti, Liu, Yongmei, Psaty, Bruce M., Ridker, Paul M., van Dam, Rob M., Kardia, Sharon L. R., Zhu, Xiaofeng, Rotimi, Charles N., Mook-Kanamori, Dennis O., Fornage, Myriam, Kelly, Tanika N., Fox, Ervin R., Hayward, Caroline, van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Liu, Jingmin, Rotter, Jerome I., Gauderman, W. James, Province, Michael A., Munroe, Patricia B., Rice, Kenneth, Chasman, Daniel I., Cupples, L. Adrienne, Rao, Dabeeru C., Morrison, Alanna C., de Vries, Paul S., Brown, Michael R., Bentley, Amy R., Sung, Yun J., Winkler, Thomas W., Ntalla, Ioanna, Schwander, Karen, Kraja, Aldi T., Guo, Xiuqing, Franceschini, Nora, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E., Musani, Solomon K., Li, Changwei, Feitosa, Mary F., Richard, Melissa A., Noordam, Raymond, Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Deng, Xuan, Dorajoo, Rajkumar, Lohman, Kurt K., Manning, Alisa K., Rankinen, Tuomo, Smith, Albert V., Tajuddin, Salman M., Evangelou, Evangelos, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E., Hartwig, Fernando P., He, Meian, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Laguzzi, Federica, Lee, Joseph H., Luan, Jian'an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M., Pietzner, Maik, Riaz, Muhammad, Said, M. Abdullah, Scott, Robert A., Sofer, Tamar, Stancakova, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O., van der Most, Peter J., Varga, Tibor V., Wang, Yajuan, Ware, Erin B., Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E., Aung, Tin, Ballantyne, Christie, Boerwinkle, Eric, Broeckel, Ulrich, Campbell, Archie, Canouil, Mickael, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Connell, John M., de Faire, Ulf, de las Fuentes, Lisa, de Mutsert, Renee, de Silva, H. Janaka, Ding, Jingzhong, Dominiczak, Anna F., Duan, Qing, Eaton, Charles B., Eppinga, Ruben N., Faul, Jessica D., Fisher, Virginia, Forrester, Terrence, Franco, Oscar H., Friedlander, Yechiel, Ghanbari, Mohsen, Giulianini, Franco, Grabe, Hans J., Grove, Megan L., Gu, C. Charles, Harris, Tamara B., Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hixson, James E., Howard, Barbara V., Ikram, M. Arfan, Jacobs, David R., Jr., Johnson, Craig, Jonas, Jost Bruno, Kammerer, Candace M., Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpelainen, Tuomas O., Koh, Woon-Puay, Koistinen, Heikki A., Kolcic, Ivana, Kooperberg, Charles, Krieger, Jose E., Kritchevsky, Steve B., Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lehne, Benjamin, Lemaitre, Rozenn N., Li, Yize, Liang, Jingjing, Liu, Jianjun, Liu, Kiang, Loh, Marie, Louie, Tin, Magi, Reedik, Manichaikul, Ani W., McKenzie, Colin A., Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L., Mosley, Thomas H., Jr., Mukamal, Kenneth J., Nalls, Mike A., Nauck, Matthias, Nelson, Christopher P., Sotoodehnia, Nona, O'Connell, Jeff R., Palmer, Nicholette D., Pazoki, Raha, Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Poulter, Neil, Raffel, Leslie J., Raitakari, Olli T., Reiner, Alex P., Rice, Treva K., Rich, Stephen S., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Sever, Peter, Shi, Yuan, Sidney, Stephen, Sims, Mario, Smith, Blair H., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tan, Nicholas, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Uitterlinden, Andre G., van Heemst, Diana, Vuckovic, Dragana, Waldenberger, Melanie, Wang, Lihua, Wang, Yujie, Wang, Zhe, Wei, Wen Bin, Williams, Christine, Wilson, Gregory, Sr., Wojczynski, Mary K., Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Deary, Ian J., Esko, Tonu, Farrall, Martin, Franks, Paul W., Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo L., Kamatani, Yoichiro, Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Leander, Karin, Lehtimaki, Terho, Magnusson, Patrik K. E., Penninx, Brenda, Pereira, Alexandre C., Rauramaa, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E., Wang, Ya Xing, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wickremasinghe, Ananda R., Zheng, Wei, Elliott, Paul, North, Kari E., Bouchard, Claude, Evans, Michele K., Gudnason, Vilmundur, Liu, Ching-Ti, Liu, Yongmei, Psaty, Bruce M., Ridker, Paul M., van Dam, Rob M., Kardia, Sharon L. R., Zhu, Xiaofeng, Rotimi, Charles N., Mook-Kanamori, Dennis O., Fornage, Myriam, Kelly, Tanika N., Fox, Ervin R., Hayward, Caroline, van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Liu, Jingmin, Rotter, Jerome I., Gauderman, W. James, Province, Michael A., Munroe, Patricia B., Rice, Kenneth, Chasman, Daniel I., Cupples, L. Adrienne, Rao, Dabeeru C., and Morrison, Alanna C.
- Abstract
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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- 2019
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181. Quality of dietary fat and genetic risk of type 2 diabetes : individual participant data meta-analysis
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Merino, Jordi, Guasch-Ferre, Marta, Ellervik, Christina, Dashti, Hassan S., Sharp, Stephen J., Wu, Peitao, Overvad, Kim, Sarnowski, Chloe, Kuokkanen, Mikko, Lemaitre, Rozenn N., Justice, Anne E., Ericson, Ulrika, Braun, Kim V. E., Mahendran, Yuvaraj, Frazier-Wood, Alexis C., Sun, Dianjianyi, Chu, Audrey Y., Tanaka, Toshiko, Luan, Jian'an, Hong, Jaeyoung, Tjonneland, Anne, Ding, Ming, Lundqvist, Annamari, Mukamal, Kenneth, Rohde, Rebecca, Schulz, Christina-Alexandra, Franco, Oscar H., Grarup, Niels, Chen, Yii-Der Ida, Bazzano, Lydia, Franks, Paul W., Buring, Julie E., Langenberg, Claudia, Liu, Ching-Ti, Hansen, Torben, Jensen, Majken K., Saaksjarvi, Katri, Psaty, Bruce M., Young, Kristin L., Hindy, George, Sandholt, Camilla Helene, Ridker, Paul M., Ordovas, Jose M., Meigs, James B., Pedersen, Oluf, Kraft, Peter, Perola, Markus, North, Kari E., Orho-Melander, Marju, Voortman, Trudy, Toft, Ulla, Rotter, Jerome I., Qi, Lu, Forouhi, Nita G., Mozaffarian, Dariush, Sorensen, Thorkild I. A., Stampfer, Meir J., Mannisto, Satu, Selvin, Elizabeth, Imamura, Fumiaki, Salomaa, Veikko, Hu, Frank B., Wareham, Nick J., Dupuis, Josee, Smith, Caren E., Kilpelainen, Tuomas O., Chasman, Daniel I., Florez, Jose C., Merino, Jordi, Guasch-Ferre, Marta, Ellervik, Christina, Dashti, Hassan S., Sharp, Stephen J., Wu, Peitao, Overvad, Kim, Sarnowski, Chloe, Kuokkanen, Mikko, Lemaitre, Rozenn N., Justice, Anne E., Ericson, Ulrika, Braun, Kim V. E., Mahendran, Yuvaraj, Frazier-Wood, Alexis C., Sun, Dianjianyi, Chu, Audrey Y., Tanaka, Toshiko, Luan, Jian'an, Hong, Jaeyoung, Tjonneland, Anne, Ding, Ming, Lundqvist, Annamari, Mukamal, Kenneth, Rohde, Rebecca, Schulz, Christina-Alexandra, Franco, Oscar H., Grarup, Niels, Chen, Yii-Der Ida, Bazzano, Lydia, Franks, Paul W., Buring, Julie E., Langenberg, Claudia, Liu, Ching-Ti, Hansen, Torben, Jensen, Majken K., Saaksjarvi, Katri, Psaty, Bruce M., Young, Kristin L., Hindy, George, Sandholt, Camilla Helene, Ridker, Paul M., Ordovas, Jose M., Meigs, James B., Pedersen, Oluf, Kraft, Peter, Perola, Markus, North, Kari E., Orho-Melander, Marju, Voortman, Trudy, Toft, Ulla, Rotter, Jerome I., Qi, Lu, Forouhi, Nita G., Mozaffarian, Dariush, Sorensen, Thorkild I. A., Stampfer, Meir J., Mannisto, Satu, Selvin, Elizabeth, Imamura, Fumiaki, Salomaa, Veikko, Hu, Frank B., Wareham, Nick J., Dupuis, Josee, Smith, Caren E., Kilpelainen, Tuomas O., Chasman, Daniel I., and Florez, Jose C.
- Abstract
OBJECTIVE To investigate whether the genetic burden of type 2 diabetes modifies the association between the quality of dietary fat and the incidence of type 2 diabetes. DESIGN Individual participant data meta-analysis. DATA SOURCES Eligible prospective cohort studies were systematically sourced from studies published between January 1970 and February 2017 through electronic searches in major medical databases (Medline, Embase, and Scopus) and discussion with investigators. REVIEW METHODS Data from cohort studies or multicohort consortia with available genome-wide genetic data and information about the quality of dietary fat and the incidence of type 2 diabetes in participants of European descent was sought. Prospective cohorts that had accrued five or more years of follow-up were included. The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes. Diet was recorded by using validated cohort-specific dietary assessment tools. Outcome measures were summary adjusted hazard ratios of incident type 2 diabetes for polygenic risk score, isocaloric replacement of carbohydrate (refined starch and sugars) with types of fat, and the interaction of types of fat with polygenic risk score. RESULTS Of 102 305 participants from 15 prospective cohort studies, 20 015 type 2 diabetes cases were documented after a median follow-up of 12 years (interquartile range 9.4-14.2). The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I-2 = 7.1%, tau(2) = 0.003). The increase of polyunsaturated fat and total omega 6 polyunsaturated fat intake in place of carbohydrate was associated with a lower risk of type 2 diabetes, with hazard ratios of 0.90 (0.82 to 0.98, I-2 = 18.0%, tau(2) = 0.006; per 5% of energy) and 0.99 (0.97 to 1.00, I-2 = 58.8%, tau(2) = 0.001; per increment of 1 g/d), respectively. Increasing monounsaturated fat in pl
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- 2019
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182. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
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Evangelou, Evangelos, Evangelou, Evangelos, Gao, He, Chu, Congying, Ntritsos, Georgios, Blakeley, Paul, Butts, Andrew R, Pazoki, Raha, Suzuki, Hideaki, Koskeridis, Fotios, Yiorkas, Andrianos M, Karaman, Ibrahim, Elliott, Joshua, Luo, Qiang, Aeschbacher, Stefanie, Bartz, Traci M, Baumeister, Sebastian E, Braund, Peter S, Brown, Michael R, Brody, Jennifer A, Clarke, Toni-Kim, Dimou, Niki, Faul, Jessica D, Homuth, Georg, Jackson, Anne U, Kentistou, Katherine A, Joshi, Peter K, Lemaitre, Rozenn N, Lind, Penelope A, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Milaneschi, Yuri, Nelson, Christopher P, Nolte, Ilja M, Perälä, Mia-Maria, Polasek, Ozren, Porteous, David, Ratliff, Scott M, Smith, Jennifer A, Stančáková, Alena, Teumer, Alexander, Tuominen, Samuli, Thériault, Sébastien, Vangipurapu, Jagadish, Whitfield, John B, Wood, Alexis, Yao, Jie, Yu, Bing, Zhao, Wei, Arking, Dan E, Auvinen, Juha, Liu, Chunyu, Männikkö, Minna, Risch, Lorenz, Rotter, Jerome I, Snieder, Harold, Veijola, Juha, Blakemore, Alexandra I, Boehnke, Michael, Campbell, Harry, Conen, David, Eriksson, Johan G, Grabe, Hans J, Guo, Xiuqing, van der Harst, Pim, Hartman, Catharina A, Hayward, Caroline, Heath, Andrew C, Jarvelin, Marjo-Riitta, Kähönen, Mika, Kardia, Sharon LR, Kühne, Michael, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lehtimäki, Terho, McIntosh, Andrew M, Mohlke, Karen L, Morrison, Alanna C, Martin, Nicholas G, Oldehinkel, Albertine J, Penninx, Brenda WJH, Psaty, Bruce M, Raitakari, Olli T, Rudan, Igor, Samani, Nilesh J, Scott, Laura J, Spector, Tim D, Verweij, Niek, Weir, David R, Wilson, James F, Levy, Daniel, Tzoulaki, Ioanna, Bell, Jimmy D, Matthews, Paul M, Rothenfluh, Adrian, Desrivières, Sylvane, Schumann, Gunter, Elliott, Paul, Evangelou, Evangelos, Evangelou, Evangelos, Gao, He, Chu, Congying, Ntritsos, Georgios, Blakeley, Paul, Butts, Andrew R, Pazoki, Raha, Suzuki, Hideaki, Koskeridis, Fotios, Yiorkas, Andrianos M, Karaman, Ibrahim, Elliott, Joshua, Luo, Qiang, Aeschbacher, Stefanie, Bartz, Traci M, Baumeister, Sebastian E, Braund, Peter S, Brown, Michael R, Brody, Jennifer A, Clarke, Toni-Kim, Dimou, Niki, Faul, Jessica D, Homuth, Georg, Jackson, Anne U, Kentistou, Katherine A, Joshi, Peter K, Lemaitre, Rozenn N, Lind, Penelope A, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Milaneschi, Yuri, Nelson, Christopher P, Nolte, Ilja M, Perälä, Mia-Maria, Polasek, Ozren, Porteous, David, Ratliff, Scott M, Smith, Jennifer A, Stančáková, Alena, Teumer, Alexander, Tuominen, Samuli, Thériault, Sébastien, Vangipurapu, Jagadish, Whitfield, John B, Wood, Alexis, Yao, Jie, Yu, Bing, Zhao, Wei, Arking, Dan E, Auvinen, Juha, Liu, Chunyu, Männikkö, Minna, Risch, Lorenz, Rotter, Jerome I, Snieder, Harold, Veijola, Juha, Blakemore, Alexandra I, Boehnke, Michael, Campbell, Harry, Conen, David, Eriksson, Johan G, Grabe, Hans J, Guo, Xiuqing, van der Harst, Pim, Hartman, Catharina A, Hayward, Caroline, Heath, Andrew C, Jarvelin, Marjo-Riitta, Kähönen, Mika, Kardia, Sharon LR, Kühne, Michael, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lehtimäki, Terho, McIntosh, Andrew M, Mohlke, Karen L, Morrison, Alanna C, Martin, Nicholas G, Oldehinkel, Albertine J, Penninx, Brenda WJH, Psaty, Bruce M, Raitakari, Olli T, Rudan, Igor, Samani, Nilesh J, Scott, Laura J, Spector, Tim D, Verweij, Niek, Weir, David R, Wilson, James F, Levy, Daniel, Tzoulaki, Ioanna, Bell, Jimmy D, Matthews, Paul M, Rothenfluh, Adrian, Desrivières, Sylvane, Schumann, Gunter, and Elliott, Paul
- Abstract
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
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- 2019
183. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
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Merino, Jordi, Merino, Jordi, Dashti, Hassan S, Li, Sherly X, Sarnowski, Chloé, Justice, Anne E, Graff, Misa, Papoutsakis, Constantina, Smith, Caren E, Dedoussis, George V, Lemaitre, Rozenn N, Wojczynski, Mary K, Männistö, Satu, Ngwa, Julius S, Kho, Minjung, Ahluwalia, Tarunveer S, Pervjakova, Natalia, Houston, Denise K, Bouchard, Claude, Huang, Tao, Orho-Melander, Marju, Frazier-Wood, Alexis C, Mook-Kanamori, Dennis O, Pérusse, Louis, Pennell, Craig E, de Vries, Paul S, Voortman, Trudy, Li, Olivia, Kanoni, Stavroula, Rose, Lynda M, Lehtimäki, Terho, Zhao, Jing Hua, Feitosa, Mary F, Luan, Jian'an, McKeown, Nicola M, Smith, Jennifer A, Hansen, Torben, Eklund, Niina, Nalls, Mike A, Rankinen, Tuomo, Huang, Jinyan, Hernandez, Dena G, Schulz, Christina-Alexandra, Manichaikul, Ani, Li-Gao, Ruifang, Vohl, Marie-Claude, Wang, Carol A, van Rooij, Frank JA, Shin, Jean, Kalafati, Ioanna P, Day, Felix, Ridker, Paul M, Kähönen, Mika, Siscovick, David S, Langenberg, Claudia, Zhao, Wei, Astrup, Arne, Knekt, Paul, Garcia, Melissa, Rao, DC, Qi, Qibin, Ferrucci, Luigi, Ericson, Ulrika, Blangero, John, Hofman, Albert, Pausova, Zdenka, Mikkilä, Vera, Wareham, Nick J, Kardia, Sharon LR, Pedersen, Oluf, Jula, Antti, Curran, Joanne E, Zillikens, M Carola, Viikari, Jorma S, Forouhi, Nita G, Ordovás, José M, Lieske, John C, Rissanen, Harri, Uitterlinden, André G, Raitakari, Olli T, Kiefte-de Jong, Jessica C, Dupuis, Josée, Rotter, Jerome I, North, Kari E, Scott, Robert A, Province, Michael A, Perola, Markus, Cupples, L Adrienne, Turner, Stephen T, Sørensen, Thorkild IA, Salomaa, Veikko, Liu, Yongmei, Sung, Yun J, Qi, Lu, Bandinelli, Stefania, Rich, Stephen S, de Mutsert, Renée, Tremblay, Angelo, Oddy, Wendy H, Franco, Oscar H, Paus, Tomas, Merino, Jordi, Merino, Jordi, Dashti, Hassan S, Li, Sherly X, Sarnowski, Chloé, Justice, Anne E, Graff, Misa, Papoutsakis, Constantina, Smith, Caren E, Dedoussis, George V, Lemaitre, Rozenn N, Wojczynski, Mary K, Männistö, Satu, Ngwa, Julius S, Kho, Minjung, Ahluwalia, Tarunveer S, Pervjakova, Natalia, Houston, Denise K, Bouchard, Claude, Huang, Tao, Orho-Melander, Marju, Frazier-Wood, Alexis C, Mook-Kanamori, Dennis O, Pérusse, Louis, Pennell, Craig E, de Vries, Paul S, Voortman, Trudy, Li, Olivia, Kanoni, Stavroula, Rose, Lynda M, Lehtimäki, Terho, Zhao, Jing Hua, Feitosa, Mary F, Luan, Jian'an, McKeown, Nicola M, Smith, Jennifer A, Hansen, Torben, Eklund, Niina, Nalls, Mike A, Rankinen, Tuomo, Huang, Jinyan, Hernandez, Dena G, Schulz, Christina-Alexandra, Manichaikul, Ani, Li-Gao, Ruifang, Vohl, Marie-Claude, Wang, Carol A, van Rooij, Frank JA, Shin, Jean, Kalafati, Ioanna P, Day, Felix, Ridker, Paul M, Kähönen, Mika, Siscovick, David S, Langenberg, Claudia, Zhao, Wei, Astrup, Arne, Knekt, Paul, Garcia, Melissa, Rao, DC, Qi, Qibin, Ferrucci, Luigi, Ericson, Ulrika, Blangero, John, Hofman, Albert, Pausova, Zdenka, Mikkilä, Vera, Wareham, Nick J, Kardia, Sharon LR, Pedersen, Oluf, Jula, Antti, Curran, Joanne E, Zillikens, M Carola, Viikari, Jorma S, Forouhi, Nita G, Ordovás, José M, Lieske, John C, Rissanen, Harri, Uitterlinden, André G, Raitakari, Olli T, Kiefte-de Jong, Jessica C, Dupuis, Josée, Rotter, Jerome I, North, Kari E, Scott, Robert A, Province, Michael A, Perola, Markus, Cupples, L Adrienne, Turner, Stephen T, Sørensen, Thorkild IA, Salomaa, Veikko, Liu, Yongmei, Sung, Yun J, Qi, Lu, Bandinelli, Stefania, Rich, Stephen S, de Mutsert, Renée, Tremblay, Angelo, Oddy, Wendy H, Franco, Oscar H, and Paus, Tomas
- Abstract
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10-6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.
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- 2019
184. An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.
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Liu, Jun, Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C, Mandaviya, Pooja R, Jansen, Rick, Peters, Marjolein J, Duijts, Liesbeth, Jaddoe, Vincent WV, Tiemeier, Henning, Felix, Janine F, Willemsen, Gonneke, de Geus, Eco JC, Chu, Audrey Y, Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L, Herder, Christian, Hidalgo, Bertha A, Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N, Jhun, Min A, Smith, Jennifer A, Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K, Grallert, Harald, Assimes, Themistocles L, Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A, van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G, Sijbrands, Eric JG, Franco, Oscar H, Dehghan, Abbas, Spector, Tim D, Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I, Meigs, James B, Pankow, James S, van Meurs, Joyce BJ, Isaacs, Aaron, Boomsma, Dorret I, Bell, Jordana T, Demirkan, Ayşe, van Duijn, Cornelia M, Liu, Jun, Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C, Mandaviya, Pooja R, Jansen, Rick, Peters, Marjolein J, Duijts, Liesbeth, Jaddoe, Vincent WV, Tiemeier, Henning, Felix, Janine F, Willemsen, Gonneke, de Geus, Eco JC, Chu, Audrey Y, Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L, Herder, Christian, Hidalgo, Bertha A, Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N, Jhun, Min A, Smith, Jennifer A, Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K, Grallert, Harald, Assimes, Themistocles L, Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A, van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G, Sijbrands, Eric JG, Franco, Oscar H, Dehghan, Abbas, Spector, Tim D, Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I, Meigs, James B, Pankow, James S, van Meurs, Joyce BJ, Isaacs, Aaron, Boomsma, Dorret I, Bell, Jordana T, Demirkan, Ayşe, and van Duijn, Cornelia M
- Abstract
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association between obesity and insulin. Our study sheds light on the biological interactions between genetic variants driving differential methylation and gene expression in the early pathogenesis of T2D.
- Published
- 2019
185. Dairy Intake and Body Composition and Cardiometabolic Traits among Adults:Mendelian Randomization Analysis of 182041 Individuals from 18 Studies
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Huang, Tao, Sun, Dianjianyi, Heianza, Yoriko, Bergholdt, Helle K. M., Gao, Meng, Fang, Zhe, Ding, Ming, Frazier-Wood, Alexis C., North, Kari E., Marouli, Eirini, Graff, Mariaelisa, Smith, Caren E., Varbo, Anette, Lemaitre, Rozenn N., Corella, Dolores, Wang, Carol A., Tjønneland, Anne, Overvad, Kim, Sørensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Mikkila, Vera, Bartz, Traci M., Psaty, Bruce M., Siscovick, David S., Danning, Rebecca D., Dedoussis, George, Pedersen, Oluf, Hansen, Torben, Havulinna, Aki S., Mannisto, Satu, Rotter, Jerome, I, Sares-Jaske, Laura, Allison, Mathew A., Rich, Stephen S., Sorli, Jose, V, Coltell, Oscar, Pennell, Craig E., Eastwood, Peter, Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Helminen, Mika, Wang, Yujie, Deloukas, Panagiotis, Knekt, Paul, Kanerva, Noora, Kilpelainen, Tuomas O., Province, Michael A., Mozaffarian, Dariush, Chasman, Daniel, I, Nordestgaard, Borge G., Ellervik, Christina, Qi, Lu, Huang, Tao, Sun, Dianjianyi, Heianza, Yoriko, Bergholdt, Helle K. M., Gao, Meng, Fang, Zhe, Ding, Ming, Frazier-Wood, Alexis C., North, Kari E., Marouli, Eirini, Graff, Mariaelisa, Smith, Caren E., Varbo, Anette, Lemaitre, Rozenn N., Corella, Dolores, Wang, Carol A., Tjønneland, Anne, Overvad, Kim, Sørensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Mikkila, Vera, Bartz, Traci M., Psaty, Bruce M., Siscovick, David S., Danning, Rebecca D., Dedoussis, George, Pedersen, Oluf, Hansen, Torben, Havulinna, Aki S., Mannisto, Satu, Rotter, Jerome, I, Sares-Jaske, Laura, Allison, Mathew A., Rich, Stephen S., Sorli, Jose, V, Coltell, Oscar, Pennell, Craig E., Eastwood, Peter, Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Helminen, Mika, Wang, Yujie, Deloukas, Panagiotis, Knekt, Paul, Kanerva, Noora, Kilpelainen, Tuomas O., Province, Michael A., Mozaffarian, Dariush, Chasman, Daniel, I, Nordestgaard, Borge G., Ellervik, Christina, and Qi, Lu
- Published
- 2019
186. Esterified Estrogens and Conjugated Equine Estrogens and the Risk of Venous Thrombosis
- Author
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Smith, Nicholas L., Heckbert, Susan R., Lemaitre, Rozenn N., Reiner, Alex P., Lumley, Thomas, Weiss, Noel S., Larson, Eric B., Rosendaal, Frits R., and Psaty, Bruce M.
- Published
- 2004
187. Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults.
- Author
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Yujin Lee, Nemet, Ina, Zeneng Wang, Lai, Heidi T. M., de Oliveira Otto, Marcia C., Lemaitre, Rozenn N., Fretts, Amanda M., Sotoodehnia, Nona, Budoff, Matthew, DiDonato, Joseph A., McKnight, Barbara, Tang, W. H. Wilson, Psaty, Bruce M., Siscovick, David S., Hazen, Stanley L., Mozaffarian, Dariush, Lee, Yujin, and Wang, Zeneng
- Published
- 2021
- Full Text
- View/download PDF
188. The risk of myocardial infarction associated with antihypertensive drug therapies
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Psaty, Bruce M., Heckbert, Susan R., Koepsell, Thomas D., Siscovick, David S., Raghunathan, Trivellore, Weiss, Noel S., Rosendaal, Frits R., Lemaitre, Rozenn N., Smith, Nicholas L., Wahl, Patricia W., Wagner, Edward H., and Furberg, Curt D.
- Subjects
Calcium channel blockers -- Adverse and side effects ,Hypertension -- Drug therapy ,Heart attack -- Risk factors - Abstract
People taking calcium channel blockers appear to have a greater risk of heart attack than those taking other classes of drugs used to lower blood pressure. Researchers studied the records of 623 patients who had heart attacks while taking antihypertensive medication and 2,032 patients who were treated for high blood pressure but did not have heart attacks. The patients ranged in age from 30 to 79. Patients taking high doses of short-acting calcium channel blockers had a 60% higher risk of heart attack compared to patients taking beta-blockers or angiotensin-converting enzyme (ACE) inhibitors. The risk, however, was small for patients on low doses of calcium channel blockers., Objective.--To assess the association between first myocardial infarction and the use of antihypertensive agents. Design and Setting.--We conducted a population-based case-control study among enrollees of the Group Health Cooperative of Puget Sound (GHC). Patients and Methods.--Cases were hypertensive patients who sustained a first fatal or nonfatal myocardial infarction from 1986 through 1993 among women and from 1989 through 1993 among men. Controls were a stratified random sample of hypertensive GHC enrollees, frequency matched to the cases on age, sex, and calendar year. All 623 cases and 2032 controls had pharmacologically treated hypertension. Data collection included a review of the ambulatory medical record and a brief telephone interview of consenting survivors. Antihypertensive therapy was assessed using the GHC's computerized pharmacy database. Results.--The first analysis included only the 335 cases and 1395 controls initially free of cardiovascular disease. Compared with users of diuretics alone, the adjusted risk ratio of myocardial infarction was increased by about 60% among users of calcium channel blockers with or without diuretics (risk ratio=1.62; 95% confidence interval [CI], 1.11 to 2.34; P=.01). The second analysis was restricted to 384 cases and 1108 controls who were taking either a calcium channel blocker or a [beta]-blocker. Among these subjects, the use of calcium channel blockers compared with [beta]-blockers was associated with about a 60% increase in the adjusted risk of myocardial infarction (risk ratio=1.57; 95% CI, 1.21 to 2.04; P Conclusions.--In this study of hypertensive patients, the use of short-acting calcium channel blockers, especially in high doses, was associated with an increased risk of myocardial infarction. Ongoing large-scale clinical trials will assess the effect of various antihypertensive therapies, including calcium channel blockers, on several important cardiovascular end points. Until these results are available, the findings of this study support the current guidelines from the Joint National Committee on the Detection, Evaluation and Treatment of High Blood Pressure that recommend diuretics and [beta]-blockers as first-line agents unless contraindicated, unacceptable, or not tolerated.
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- 1995
189. Hormone Replacement Therapy and Associated Risk of Stroke in Postmenopausal Women
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Lemaitre, Rozenn N., Heckbert, Susan R., Psaty, Bruce M., Smith, Nicholas L., Kaplan, Robert C., and Longstreth, W. T., Jr
- Published
- 2002
190. Smoking Status and Risk for Recurrent Coronary Events after Myocardial Infarction
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Rea, Thomas D., Heckbert, Susan R., Kaplan, Robert C., Smith, Nicholas L., Lemaitre, Rozenn N., and Psaty, Bruce M.
- Published
- 2002
191. Therapy With Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors (Statins) and Associated Risk of Incident Cardiovascular Events in Older Adults: Evidence From the Cardiovascular Health Study
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Lemaitre, Rozenn N., Psaty, Bruce M., Heckbert, Susan R., Kronmal, Richard A., Newman, Anne B., and Burke, Gregory L.
- Published
- 2002
192. Diuretic Therapy, the α-Adducin Gene Variant, and the Risk of Myocardial Infarction or Stroke in Persons With Treated Hypertension
- Author
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Psaty, Bruce M., Smith, Nicholas L., Heckbert, Susan R., Vos, Hans L., Lemaitre, Rozenn N., Reiner, Alexander P., Siscovick, David S., Bis, Joshua, Lumley, Thomas, Longstreth, W. T., Jr, and Rosendaal, Frits R.
- Published
- 2002
193. n-3 polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
- Author
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Lemaitre, Rozenn N, King, Irena B, Mozaffarian, Dariush, Kuller, Lewis H, Tracy, Russell P, and Siscovick, David S
- Subjects
Unsaturated fatty acids -- Health aspects ,Omega-3 fatty acids -- Health aspects ,Aged -- Food and nutrition ,Food/cooking/nutrition ,Health - Abstract
Background: Little is known about the relation of the dietary intake of n-3 polyunsaturated fatty acids, ie, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from fatty fish and [alpha]-linolenic acid from vegetable oils, with ischemic heart disease among older adults. Objective: We investigated the associations of plasma phospholipid concentrations of DHA, EPA, and [alpha]-linolenic acid as biomarkers of intake with the risk of incident fatal ischemic heart disease and incident nonfatal myocardial infarction in older adults. Design: We conducted a case-control study nested in the Cardiovascular Health Study, a cohort study of adults aged [greater than or equal to] 65 y. Cases experienced incident fatal myocardial infarction and other ischemic heart disease death (n = 54) and incident nonfatal myocardial infarction (n = 125). Matched controls were randomly selected (n = 179). We measured plasma phospholipid concentrations of n-3 polyunsaturated fatty acids in blood samples drawn [approximately equal to] 2 y before the event. Results: A higher concentration of combined DHA and EPA was associated with a lower risk of fatal ischemic heart disease, and a higher concentration of [alpha]-linolenic acid with a tendency to lower risk, after adjustment for risk factors [odds ratio: 0.32 (95% CI: 0.13, 0.78; P = 0.01) and 0.52 (0.24, 1.15; P = 0.1), respectively]. In contrast, n-3 polyunsaturated fatty acids were not associated with nonfatal myocardial infarction. Conclusions: Higher combined dietary intake of DHA and EPA, and possibly [alpha]-linolenic acid, may lower the risk of fatal ischemic heart disease in older adults. The association of n-3 polyunsaturated fatty acids with fatal ischemic heart disease, but not with nonfatal myocardial infarction, is consistent with possible antiarrhythmic effects of these fatty acids. KEY WORDS Fatty acids, n-3 fatty acids, phospholipids, ischemic heart disease, myocardial infarction, nested case-control studies, docosahexaenoic acid, eicosapentaenoic acid, older adults, Cardiovascular Health Study
- Published
- 2003
194. Inhaled beta-2 adrenergic receptor agonists and primary cardiac arrest
- Author
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Lemaitre, Rozenn N., Siscovick, David S., Psaty, Bruce M., Pearce, Rachel M., Raghunathan, Trivellore E., Whitsel, Eric A., Weinmann, Sheila A., Anderson, Gail D., and Lin, Danyu
- Subjects
Cardiac arrest -- Risk factors ,Adrenergic beta agonists -- Adverse and side effects ,Health ,Health care industry - Published
- 2002
195. Hormone Replacement Therapy, Prothrombotic Mutations, and the Risk of Incident Nonfatal Myocardial Infarction in Postmenopausal Women
- Author
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Psaty, Bruce M., Smith, Nicholas L., Lemaitre, Rozenn N., Vos, Hans L., Heckbert, Susan R., LaCroix, Andrea Z., and Rosendaal, Frits R.
- Published
- 2001
196. Antihypertensive Drug Therapies and the Risk of Ischemic Stroke
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Klungel, Olaf H., Heckbert, Susan R., Longstreth, W. T., Jr, Furberg, Curt D., Kaplan, Robert C., Smith, Nicholas L., Lemaitre, Rozenn N., Leufkens, Hubert G. M., de Boer, Anthonius, and Psaty, Bruce M.
- Published
- 2001
197. Serum potassium and stroke risk among treated hypertensive adults
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Smith, Nicholas L, Lemaitre, Rozenn N, Heckbert, Susan R, Kaplan, Robert C, Tirschwell, David L, Longstreth, W.T, Jr, and Psaty, Bruce M
- Published
- 2003
- Full Text
- View/download PDF
198. n−3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
- Author
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Lemaitre, Rozenn N, King, Irena B, Mozaffarian, Dariush, Kuller, Lewis H, Tracy, Russell P, and Siscovick, David S
- Published
- 2003
- Full Text
- View/download PDF
199. Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients
- Author
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Bis, Joshua C., Smith, Nicholas L., Psaty, Bruce M., Heckbert, Susan R., Edwards, Karen L., Lemaitre, Rozenn N., Lumley, Thomas, and Rosendaal, Frits R.
- Published
- 2003
- Full Text
- View/download PDF
200. Influenza Vaccination and the Risk of Primary Cardiac Arrest
- Author
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Siscovick, David S., Raghunathan, T. E., Lin, Danyu, Weinmann, Sheila, Arbogast, Patrick, Lemaitre, Rozenn N., Psaty, Bruce M., Alexander, Russell, and Cobb, Leonard A.
- Published
- 2000
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