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Quality of dietary fat and genetic risk of type 2 diabetes:individual participant data meta-analysis

Authors :
Merino, Jordi
Guasch-Ferré, Marta
Ellervik, Christina
Dashti, Hassan S
Sharp, Stephen J
Wu, Peitao
Overvad, Kim
Sarnowski, Chloé
Kuokkanen, Mikko
Lemaitre, Rozenn N
Justice, Anne E
Ericson, Ulrika
Braun, Kim V E
Mahendran, Yuvaraj
Frazier-Wood, Alexis C
Sun, Dianjianyi
Chu, Audrey Y
Tanaka, Toshiko
Luan, Jian'an
Hong, Jaeyoung
Tjønneland, Anne
Ding, Ming
Lundqvist, Annamari
Mukamal, Kenneth
Rohde, Rebecca
Schulz, Christina-Alexandra
Franco, Oscar H
Grarup, Niels
Chen, Yii-Der Ida
Bazzano, Lydia
Franks, Paul W
Buring, Julie E
Langenberg, Claudia
Liu, Ching-Ti
Hansen, Torben
Jensen, Majken K
Sääksjärvi, Katri
Psaty, Bruce M
Young, Kristin L
Hindy, George
Sandholt, Camilla Helene
Ridker, Paul M
Ordovas, Jose M
Meigs, James B
Pedersen, Oluf
Kraft, Peter
Perola, Markus
North, Kari E
Orho-Melander, Marju
Voortman, Trudy
Toft, Ulla
Rotter, Jerome I
Qi, Lu
Forouhi, Nita G
Mozaffarian, Dariush
Sørensen, Thorkild I A
Stampfer, Meir J
Männistö, Satu
Selvin, Elizabeth
Imamura, Fumiaki
Salomaa, Veikko
Hu, Frank B
Wareham, Nick J
Dupuis, Josée
Smith, Caren E
Kilpeläinen, Tuomas O
Chasman, Daniel I
Florez, Jose C
Merino, Jordi
Guasch-Ferré, Marta
Ellervik, Christina
Dashti, Hassan S
Sharp, Stephen J
Wu, Peitao
Overvad, Kim
Sarnowski, Chloé
Kuokkanen, Mikko
Lemaitre, Rozenn N
Justice, Anne E
Ericson, Ulrika
Braun, Kim V E
Mahendran, Yuvaraj
Frazier-Wood, Alexis C
Sun, Dianjianyi
Chu, Audrey Y
Tanaka, Toshiko
Luan, Jian'an
Hong, Jaeyoung
Tjønneland, Anne
Ding, Ming
Lundqvist, Annamari
Mukamal, Kenneth
Rohde, Rebecca
Schulz, Christina-Alexandra
Franco, Oscar H
Grarup, Niels
Chen, Yii-Der Ida
Bazzano, Lydia
Franks, Paul W
Buring, Julie E
Langenberg, Claudia
Liu, Ching-Ti
Hansen, Torben
Jensen, Majken K
Sääksjärvi, Katri
Psaty, Bruce M
Young, Kristin L
Hindy, George
Sandholt, Camilla Helene
Ridker, Paul M
Ordovas, Jose M
Meigs, James B
Pedersen, Oluf
Kraft, Peter
Perola, Markus
North, Kari E
Orho-Melander, Marju
Voortman, Trudy
Toft, Ulla
Rotter, Jerome I
Qi, Lu
Forouhi, Nita G
Mozaffarian, Dariush
Sørensen, Thorkild I A
Stampfer, Meir J
Männistö, Satu
Selvin, Elizabeth
Imamura, Fumiaki
Salomaa, Veikko
Hu, Frank B
Wareham, Nick J
Dupuis, Josée
Smith, Caren E
Kilpeläinen, Tuomas O
Chasman, Daniel I
Florez, Jose C
Source :
Merino , J , Guasch-Ferré , M , Ellervik , C , Dashti , H S , Sharp , S J , Wu , P , Overvad , K , Sarnowski , C , Kuokkanen , M , Lemaitre , R N , Justice , A E , Ericson , U , Braun , K V E , Mahendran , Y , Frazier-Wood , A C , Sun , D , Chu , A Y , Tanaka , T , Luan , J , Hong , J , Tjønneland , A , Ding , M , Lundqvist , A , Mukamal , K , Rohde , R , Schulz , C-A , Franco , O H , Grarup , N , Chen , Y-D I , Bazzano , L , Franks , P W , Buring , J E , Langenberg , C , Liu , C-T , Hansen , T , Jensen , M K , Sääksjärvi , K , Psaty , B M , Young , K L , Hindy , G , Sandholt , C H , Ridker , P M , Ordovas , J M , Meigs , J B , Pedersen , O , Kraft , P , Perola , M , North , K E , Orho-Melander , M , Voortman , T , Toft , U , Rotter , J I , Qi , L , Forouhi , N G , Mozaffarian , D , Sørensen , T I A , Stampfer , M J , Männistö , S , Selvin , E , Imamura , F , Salomaa , V , Hu , F B , Wareham , N J , Dupuis , J , Smith , C E , Kilpeläinen , T O , Chasman , D I & Florez , J C 2019 , ' Quality of dietary fat and genetic risk of type 2 diabetes : individual participant data meta-analysis ' , BMJ (Clinical research ed.) , vol. 366 , pp. l4292 .
Publication Year :
2019

Abstract

OBJECTIVE: To investigate whether the genetic burden of type 2 diabetes modifies the association between the quality of dietary fat and the incidence of type 2 diabetes.DESIGN: Individual participant data meta-analysis.DATA SOURCES: Eligible prospective cohort studies were systematically sourced from studies published between January 1970 and February 2017 through electronic searches in major medical databases (Medline, Embase, and Scopus) and discussion with investigators.REVIEW METHODS: Data from cohort studies or multicohort consortia with available genome-wide genetic data and information about the quality of dietary fat and the incidence of type 2 diabetes in participants of European descent was sought. Prospective cohorts that had accrued five or more years of follow-up were included. The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes. Diet was recorded by using validated cohort-specific dietary assessment tools. Outcome measures were summary adjusted hazard ratios of incident type 2 diabetes for polygenic risk score, isocaloric replacement of carbohydrate (refined starch and sugars) with types of fat, and the interaction of types of fat with polygenic risk score.RESULTS: Of 102 305 participants from 15 prospective cohort studies, 20 015 type 2 diabetes cases were documented after a median follow-up of 12 years (interquartile range 9.4-14.2). The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I2=7.1%, τ2=0.003). The increase of polyunsaturated fat and total omega 6 polyunsaturated fat intake in place of carbohydrate was associated with a lower risk of type 2 diabetes, with hazard ratios of 0.90 (0.82 to 0.98, I2=18.0%, τ2=0.006; per 5% of energy) and 0.99 (0.97 to 1.00, I2=58.8%, τ2=0.001; per increment of 1 g/d), respectively. Increasing monounsaturated fat

Details

Database :
OAIster
Journal :
Merino , J , Guasch-Ferré , M , Ellervik , C , Dashti , H S , Sharp , S J , Wu , P , Overvad , K , Sarnowski , C , Kuokkanen , M , Lemaitre , R N , Justice , A E , Ericson , U , Braun , K V E , Mahendran , Y , Frazier-Wood , A C , Sun , D , Chu , A Y , Tanaka , T , Luan , J , Hong , J , Tjønneland , A , Ding , M , Lundqvist , A , Mukamal , K , Rohde , R , Schulz , C-A , Franco , O H , Grarup , N , Chen , Y-D I , Bazzano , L , Franks , P W , Buring , J E , Langenberg , C , Liu , C-T , Hansen , T , Jensen , M K , Sääksjärvi , K , Psaty , B M , Young , K L , Hindy , G , Sandholt , C H , Ridker , P M , Ordovas , J M , Meigs , J B , Pedersen , O , Kraft , P , Perola , M , North , K E , Orho-Melander , M , Voortman , T , Toft , U , Rotter , J I , Qi , L , Forouhi , N G , Mozaffarian , D , Sørensen , T I A , Stampfer , M J , Männistö , S , Selvin , E , Imamura , F , Salomaa , V , Hu , F B , Wareham , N J , Dupuis , J , Smith , C E , Kilpeläinen , T O , Chasman , D I & Florez , J C 2019 , ' Quality of dietary fat and genetic risk of type 2 diabetes : individual participant data meta-analysis ' , BMJ (Clinical research ed.) , vol. 366 , pp. l4292 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1204244566
Document Type :
Electronic Resource