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The circulation and water mass properties in the Eurasian Basin are discussed based on a review of previous research and an examination of observations made in recent years within, or parallel to, DAMOCLES (Developing Arctic Modelling and Observational Capabilities for Long-term Environmental Studies). The discussion is strongly biased towards observations made from icebreakers and particularly from the cruise with R/V Polarstern 2007 during the International Polar Year (IPY). Focus is on the Barents Sea inflow branch and its mixing with the Fram Strait inflow branch. It is proposed that the Barents Sea branch contributes not just intermediate water but also most of the Atlantic layer that is found in the Amundsen Basin and also in the Makarov and Canada basins. Only occasionally would high temperature pulses originating from the Fram Strait branch penetrate along the Laptev Sea slope across the Gakkel Ridge into the Amundsen Basin. Interactions between the Barents Sea and the Fram Strait branches lead to formation of intrusive layers, in the Atlantic layer and in the intermediate waters. The intrusion characteristics found downstream north of the Laptev Sea are similar to those observed in the Northern Nansen Basin and over the Gakkel Ridge, implying a flow from the Laptev Sea towards Fram Strait. The formation mechanisms for the intrusions at the continental slope, or in the interior of the basins if they are reformed there, have not been identified. The temperature of the deep water of the Eurasian Basin has increased in the last 10 yr rather more than expected from geothermal heating. That geothermal heating does influence the deep water column was obvious from 2007 Polarstern observations made close to a hydrothermal vent in the Gakkel Ridge, where the temperature minimum usually found above the 600- 800m thick homogenous bottom layer was absent. However, heat entrained from the Atlantic water into descending boundary plumes may also contribute to the warming of the deeper layers. [ABSTRACT FROM AUTHOR]

The Arctic Ocean gains freshwater mainly through river discharge, precipitation and the inflowing low salinity waters from the Pacific Ocean. In addition the recent reduction in sea ice volume is likely to influence the surface salinity and thus contribute to he freshwater content in the upper ocean. The present day freshwater storage in the Arctic Ocean appears to be sufficient to maintain the upper ocean stratification and to protect the sea ice from the deep ocean heat content. The recent freshening has not, despite the established strong stratification, been able to restrain the accelerating ice loss and other possible heat sources besides the Atlantic Water, such as the waters advecting from the Pacific Ocean and the solar insolation warming the Polar Mixed Layer, are investigated. Since the ongoing freshening, oceanic heat sources and the sea ice melt are closely related, this study, based on hydrographic observations, attempts to examine the ongoing variability in time and space in relation to these three properties. The largest time and space variability of freshwater content occurs in the Polar Mixed Layer and the upper halocline. The freshening of the upper ocean during the 2000s is ubiquitous in the Arctic Ocean although the most substantial increase occurs in the Canada Basin where the freshwater is accumulating in the thickening upper halocline. Whereas the salinity of the upper halocline is nearly constant, the freshwater content in the Polar Mixed Layer is increasing due to decreasing salinity. The decrease in salinity is likely to result from the recent changes in ice formation and melting. In contrast, in the Eurasian Basin where the seasonal ice melt has remained rather modest, the freshening of both the Polar Mixed Layer and the upper halocline is mainly of advective origin. While the warming of the Atlantic inflow was widespread in the Arctic Ocean during the 1990s, the warm and saline inflow events in the early 2000s appear to circulate mainly in the Nansen Basin. Nevertheless, even in the Nansen Basin the seasonal ice melt appears independent of the continuously increasing heat content in the Atlantic layer. As no other oceanic heat sources can be identified in the upper layers, it is likely that increased absorption of solar energy has been causing the ice melt prior to the observations. [ABSTRACT FROM AUTHOR]

Objective: To investigate the association between the use of benzodiazepines (BDZs) and BDZ-related drugs and mortality among community-dwelling people aged 65 years and older in Finland.Method: This was a population-based retrospective cohort study. Records of all reimbursed drugs purchased by all 2224 residents of Leppävirta, Finland, aged 65 years and older in 2000 were extracted from the Finnish National Prescription Register. Diagnostic data were extracted from the Special Reimbursement Register. All-cause mortality was assessed after 9 years using national registers. Cox proportional hazards models were used to compute unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals for mortality among prevalent users of BDZs and BDZ-related drugs in 2000 (n = 325), compared with nonusers of BDZs and BDZ-related drugs between 2000 and 2008 (n = 1520).Results: BDZs and BDZ-related drugs were used by 325 out of the 2224 residents (14.6%) in 2000. The 9-year mortality was 50.2% among BDZ and BDZ-related drug users in 2000 and 36.3% among BDZ and BDZ-related drug nonusers between 2000 and 2008 (HR 1.53; 95% CI 1.28 to 1.82). After adjusting for baseline age, sex, antipsychotic drug use, and diagnostic confounders, the HR was 1.01 (95% CI 0.84 to 1.21).Conclusions: Use of BDZs and BDZ-related drugs was associated with an increased mortality hazard in unadjusted analyses. However, after adjusting for age, sex, antipsychotic drug use, and diagnostic confounders, the use of BDZs and BDZ-related drugs was not associated with excess mortality. [ABSTRACT FROM AUTHOR]

Data mining of digital dental records provides possibilities for analysing the variation between dentists when diagnosing caries. A total of 71,317 male and 82,302 female subjects visited the health centres in Vantaa and Kemi during the ‘digital era’ (1994–2005). As subjects were classified as ‘new patients’ at the first examination, all re-examinations of the same subjects thereafter by the same dentist produced ‘old patients’. A mean number of decayed surfaces (DS) was counted as a function of the age of the subject during the follow-up. The significance of the difference between old and new patients was determined by the Mann-Whitney test for each age cohort at the cross sections, and for the whole follow-up. Caries was seen to affect new patients more than the old ones in both health centres after the age of 20 years. The mean DS values were the same, reaching about 1 for new and old patients at the age of 15 years. The mean DS had a peak for new patients in both health centres at the age of 25 years and another peak around 45–50 years in Kemi. With a few exceptions there was a significant difference between the DS values of new and old patients at most cross sections and for the whole follow-up time. Evidently dentists examine new patients more carefully than their old patients. After the age of 18 years patients may have changed their dentists because they have finished the free-of-charge treatment period. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

We previously showed cell-cell contacts of human dermal fibroblasts to induce expression of the hepatocyte growth factor/scatter factor (HGF) in a process designated as nemosis. Now we report on nemosis initiation in bone marrow mesenchymal stem cells (BMSCs). Because BMSCs are being used increasingly in cell transplantation therapy we aimed to demonstrate a functional effect and benefit of BMSC nemosis for wound healing. Nemotic and monolayer cells were used to stimulate HaCaT keratinocyte migration in a scratch-wound healing assay. Both indicators of nemosis, HGF production and cyclooxygenase-2 expression, were induced in BMSC spheroids. When compared with a similar amount of cells as monolayer, nemotic cells induced keratinocyte in vitro scratch-wound healing in a concentration-dependent manner. The HGF receptor, c-Met, was rapidly phosphorylated in the nemosis-stimulated keratinocytes. Nemosis-induced in vitro scratch-wound healing was inhibited by an HGF-neutralizing antibody as well as the small molecule c-Met inhibitor, SU11274. HGF-induced in vitro scratch-wound healing was inhibited by PI3K inhibitors, wortmannin and LY294002, while LY303511, an inactive structural analogue of LY294002, had no effect. Inhibitors of the mitogen-activated protein kinases MEK/ERK1/2 (PD98059 and U0126), and p38 (SB203580) attenuated HGF-induced keratinocyte in vitro scratch-wound healing. We conclude that nemosis of BMSCs can induce keratinocyte in vitro scratch-wound healing, and that in this effect signaling via HGF/c-Met is involved. [ABSTRACT FROM AUTHOR]

The article presents questions and answers related to the role of transfusion therapies services in cellular therapy including the procedures where transfusion services would be involved, the disciplines in which transfusion services would cooperate as well as the disciplines that would cooperate for cellular therapies.

Objectives: In paediatric pharmacotherapy, many drugs are prescribed to be given in ways and for conditions not approved in the marketing authorization (MA). Thus, off-label prescribing of drugs with no MA is widespread in paediatric wards. However, drug MA status and clinical practices differ across countries. In this prospective study, we studied the prescribing of off-label and unlicensed drugs in three paediatric wards in a tertiary hospital in Finland. Furthermore, we reviewed previous published studies to provide an up-to-date international perspective on prescribing of off-label and unlicensed drugs for hospitalized children. Methods: During a 2-week period, prescriptions for patients under 18 years of age (median age 1·6 years) in three wards; neonatal intensive care unit (NICU), general paediatric ward and paediatric surgical ward were recorded daily and drug-licensing status of all prescriptions was determined according to the approved summary of product characteristics. Published studies were retrieved through electronic searches, including MEDLINE (PubMed). Results: Of the 141 children, 108 received 629 prescriptions. Of the 108 children with a prescription, 82 (76%) had at least one off-label or unlicensed drug prescribed; 79% in the NICU, 63% in the general ward and 91% in the surgical ward ( P = 0·014). Of the 108 children with a prescription, 26 (24%) received prescriptions for licensed drugs, 71 (66%) received prescriptions off-label and 36 (33%) for unlicensed drugs. Of all 629 prescriptions, 321 (51%) were for licensed drugs, 226 (36%) for off-label and 82 (13%) for unlicensed drugs. International studies showed similar extents of off-label and unlicensed-drug prescribing. Conclusion: This study indicates that the use of off-label and unlicensed drugs is widespread in all the different paediatric wards surveyed and was as extensive as those reported for other countries. [ABSTRACT FROM AUTHOR]

Aim: This study aims at examining the effects of progressive strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in older sprint-trained athletes. Methods: Eleven men (52–78 years) were randomized to a training (EX, n = 7) or control (CTRL, n = 4) group. EX participated in a 20-week programme that combined sprint training with heavy and explosive strength exercises, while CTRL maintained their usual run-based training schedules. Results: EX improved maximal isometric and dynamic leg strength, explosive jump performance and force production in running. Specific tension and maximum shortening velocity of single fibres from the vastus lateralis were not altered in EX or CTRL. Fibre type and myosin heavy chain isoform distributions remained unchanged in the two groups. There was a general increase in fibre areas in EX, but this was significant only in IIa fibres. The 10% increase in squat jump in EX was accompanied by a 9% increase in the integrated EMG (iEMG) of the leg extensors but the 21–40% increases in isometric and dynamic strength were not paralleled by changes in iEMG. Conclusion: Adding strength training stimulus to the training programme improved maximal, explosive and sport-specific force production in elite master sprinters. These improvements were primarily related to hypertrophic muscular adaptations. [ABSTRACT FROM AUTHOR]

Virtanen JK, Voutilainen S, Alfthan G, Korhonen MJ, Rissanen TH, Mursu J, Kaplan GA, Salonen JT (University of Kuopio, Kuopio; National Public Health Institute, Helsinki, Finland; University of Michigan, Ann Arbor, USA; and Oy Jurilab Ltd, Kuopio, Finland). Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.J Intern Med2005;257:255–262.Based on case–control and prospective studies elevated blood total homocysteine (tHcy) has been suggested to be an independent risk factor for cardiovascular diseases (CVD). The purpose of the study was to explore the joint effect of increased serum tHcy concentration and other risk factors on the risk of CVD mortality in middle-aged men without a history of heart disease or stroke.A prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.Eastern Finland.A total of 802 men aged 46–64 years, examined in 1991–93.CVD mortality event.The mean serum tHcy concentration was 10.8 μmol L−1 (SD 3.3). During the average follow-up time of 10.8 years 50 men experienced a CVD death. The hazard rate ratio for CVD mortality was 1.80 (95% confidence interval: 1.02–3.19) in men in the highest serum tHcy third versus lower thirds after adjustment for cardiovascular risk factors. Furthermore, elevated serum tHcy concentration appeared to increase the risk of CVD death in men who smoke or who have high circulating concentrations of serum total or LDL cholesterol, apo-B apolipoprotein or plasma fibrinogen.We conclude that homocysteine may increase the risk of CVD mortality in middle-aged men from Eastern Finland, and it may especially increase the risk when present with other risk factors for CVD. [ABSTRACT FROM AUTHOR]