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2,327 results on '"Kadowaki T."'

152. Evaluation of cutoff scores for the Parkinson's disease sleep scale-2

Author

Suzuki, K., primary, Miyamoto, T., additional, Miyamoto, M., additional, Suzuki, S., additional, Numao, A., additional, Watanabe, Y., additional, Tatsumoto, M., additional, Sakuta, H., additional, Fujita, H., additional, Iwanami, M., additional, Sada, T., additional, Kadowaki, T., additional, Hashimoto, K., additional, Trenkwalder, C., additional, and Hirata, K., additional

Published
2014
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154. Comprehensive Analysis of Serum Biomarker and Tumor Gene Mutation Associated with Clinical Outcomes in the Phase 3 Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (Select)

Author

Tahara, M., primary, Schlumberger, M., additional, Wirth, L.J., additional, Elisei, R., additional, Brose, M., additional, Habra, M.A., additional, Newbold, K., additional, Kiyota, N., additional, Dutcus, C., additional, Zhu, J., additional, Kadowaki, T., additional, Funahashi, Y., additional, Robinson, B., additional, and Sherman, S., additional

Published
2014
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156. Modification of the Excess Risk of Coronary Heart Disease Due to Smoking by Seafood/Fish Intake

Author

Eshak, E. S., primary, Iso, H., additional, Yamagishi, K., additional, Kokubo, Y., additional, Saito, I., additional, Yatsuya, H., additional, Sawada, N., additional, Inoue, M., additional, Tsugane, S., additional, Sobue, T., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Doi, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Sakurai, S., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Noda, M., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Nakamura, K., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Yasuda, N., additional, and Kono, S., additional

Published
2014
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158. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Author

Ma, RCW, Hu, C, Tam, CH, Zhang, R, Kwan, P, Leung, TF, Thomas, GN, Go, MJ, Hara, K, Sim, X, Ho, JSK, Wang, C, Li, H, Lu, L, Wang, Y, Li, JW, Lam, VKL, Wang, J, Yu, W, Kim, YJ, Ng, DP, Fujita, H, Panoutsopoulou, K, Day-Williams, AG, Lee, HM, Ng, ACW, Fang, Y-J, Kong, APS, Jiang, F, Ma, X, Hou, X, Tang, S, Lu, J, Yamauchi, T, Tsui, SKW, Woo, J, Leung, PC, Zhang, X, Tang, NLS, Sy, HY, Liu, J, Wong, TY, Lee, JY, Maeda, S, Xu, G, Cherny, SS, Chan, TF, Ng, MCY, Xiang, K, Morris, AP, Keildson, S, Hu, R, Ji, L, Lin, X, Cho, YS, Kadowaki, T, Tai, ES, Zeggini, E, McCarthy, MI, Hon, KL, Baum, L, Tomlinson, B, So, WY, Bao, Y, Chan, JCN, Jia, W, Ma, RCW, Hu, C, Tam, CH, Zhang, R, Kwan, P, Leung, TF, Thomas, GN, Go, MJ, Hara, K, Sim, X, Ho, JSK, Wang, C, Li, H, Lu, L, Wang, Y, Li, JW, Lam, VKL, Wang, J, Yu, W, Kim, YJ, Ng, DP, Fujita, H, Panoutsopoulou, K, Day-Williams, AG, Lee, HM, Ng, ACW, Fang, Y-J, Kong, APS, Jiang, F, Ma, X, Hou, X, Tang, S, Lu, J, Yamauchi, T, Tsui, SKW, Woo, J, Leung, PC, Zhang, X, Tang, NLS, Sy, HY, Liu, J, Wong, TY, Lee, JY, Maeda, S, Xu, G, Cherny, SS, Chan, TF, Ng, MCY, Xiang, K, Morris, AP, Keildson, S, Hu, R, Ji, L, Lin, X, Cho, YS, Kadowaki, T, Tai, ES, Zeggini, E, McCarthy, MI, Hon, KL, Baum, L, Tomlinson, B, So, WY, Bao, Y, Chan, JCN, and Jia, W

Abstract

AIMS/HYPOTHESIS: Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. METHODS: We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations. RESULTS: We identified CDKN2A/B and four novel type 2 diabetes association signals with p < 1 × 10(-5) from the meta-analysis. Thirteen variants within these four loci were followed up in two independent Chinese cohorts, and rs10229583 at 7q32 was found to be associated with type 2 diabetes in a combined analysis of 11,067 cases and 7,929 controls (p meta = 2.6 × 10(-8); OR [95% CI] 1.18 [1.11, 1.25]). In silico replication revealed consistent associations across multiethnic groups, including five East Asian populations (p meta = 2.3 × 10(-10)) and a population of European descent (p = 8.6 × 10(-3)). The rs10229583 risk variant was associated with elevated fasting plasma glucose, impaired beta cell function in controls, and an earlier age at diagnosis for the cases. The novel variant lies within an islet-selective cluster of open regulatory elements. There was significant heterogeneity of effect between Han Chinese and individuals of European descent, Malaysians and Indians. CONCLUSIONS/INTERPRETATION: Our study identifies rs10229583 near PAX4 as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the pathogenesis of type 2 diabetes.

Published
2013

159. Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

Author

Saxena, R, Saleheen, D, Been, LF, Garavito, ML, Braun, T, Bjonnes, A, Young, R, Ho, WK, Rasheed, A, Frossard, P, Sim, X, Hassanali, N, Radha, V, Chidambaram, M, Liju, S, Rees, SD, Ng, DP-K, Wong, T-Y, Yamauchi, T, Hara, K, Tanaka, Y, Hirose, H, McCarthy, MI, Morris, AP, Basit, A, Barnett, AH, Katulanda, P, Matthews, D, Mohan, V, Wander, GS, Singh, JR, Mehra, NK, Ralhan, S, Kamboh, MI, Mulvihill, JJ, Maegawa, H, Tobe, K, Maeda, S, Cho, YS, Tai, ES, Kelly, MA, Chambers, JC, Kooner, JS, Kadowaki, T, Deloukas, P, Rader, DJ, Danesh, J, Sanghera, DK, Saxena, R, Saleheen, D, Been, LF, Garavito, ML, Braun, T, Bjonnes, A, Young, R, Ho, WK, Rasheed, A, Frossard, P, Sim, X, Hassanali, N, Radha, V, Chidambaram, M, Liju, S, Rees, SD, Ng, DP-K, Wong, T-Y, Yamauchi, T, Hara, K, Tanaka, Y, Hirose, H, McCarthy, MI, Morris, AP, Basit, A, Barnett, AH, Katulanda, P, Matthews, D, Mohan, V, Wander, GS, Singh, JR, Mehra, NK, Ralhan, S, Kamboh, MI, Mulvihill, JJ, Maegawa, H, Tobe, K, Maeda, S, Cho, YS, Tai, ES, Kelly, MA, Chambers, JC, Kooner, JS, Kadowaki, T, Deloukas, P, Rader, DJ, Danesh, J, and Sanghera, DK

Abstract

We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs) (P < 10⁻³) in Punjabi Sikhs (n = 2,819; 801 case subjects). We further replicated 66 SNPs (P < 10⁻⁴) through genotyping in a Punjabi Sikh sample (n = 2,894; 1,711 case subjects). On combined meta-analysis in Sikh populations (n = 7,329; 3,354 case subjects), we identified a novel locus in association with T2D at 13q12 represented by a directly genotyped intronic SNP (rs9552911, P = 1.82 × 10⁻⁸) in the SGCG gene. Next, we undertook in silico replication (stage 2b) of the top 513 signals (P < 10⁻³) in 29,157 non-Sikh South Asians (10,971 case subjects) and de novo genotyping of up to 31 top signals (P < 10⁻⁴) in 10,817 South Asians (5,157 case subjects) (stage 3b). In combined South Asian meta-analysis, we observed six suggestive associations (P < 10⁻⁵ to < 10⁻⁷), including SNPs at HMG1L1/CTCFL, PLXNA4, SCAP, and chr5p11. Further evaluation of 31 top SNPs in 33,707 East Asians (16,746 case subjects) (stage 3c) and 47,117 Europeans (8,130 case subjects) (stage 3d), and joint meta-analysis of 128,127 individuals (44,358 case subjects) from 27 multiethnic studies, did not reveal any additional loci nor was there any evidence of replication for the new variant. Our findings provide new evidence on the presence of a population-specific signal in relation to T2D, which may provide additional insights into T2D pathogenesis.

Published
2013

160. The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

Author

Grarup, N, Overvad, M, Sparsø, T, Witte, D R, Pisinger, C, Jørgensen, Torben, Yamauchi, T, Hara, K, Maeda, S, Kadowaki, T, Hansen, T, Pedersen, Oluf, Grarup, N, Overvad, M, Sparsø, T, Witte, D R, Pisinger, C, Jørgensen, Torben, Yamauchi, T, Hara, K, Maeda, S, Kadowaki, T, Hansen, T, and Pedersen, Oluf

Abstract

A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked for potential associations between the diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant and diabetes-related intermediary traits.

Published
2011

161. Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality.

Author

Masuda S, Kadowaki T, Kumaki N, Tang X, Tokuda Y, Yoshimura S, Takekoshi S, Osamura RY, Masuda, S, Kadowaki, T, Kumaki, N, Tang, X, Tokuda, Y, Yoshimura, S, Takekoshi, S, and Osamura, R Y

Abstract

Background: It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressive treatment.Methods: We investigated the novel method of analysing gene alterations of mitochondrial DNA D-loop region (GAMDDL) and compared it with the conventional method of analysing the X-chromosome-linked human androgen receptor (HUMARA). The FFPE sections of primary and secondary breast cancers, the non-neoplastic mammary gland, and lymph nodes were examined.Results: Informative rates for HUMARA, GAMDDL, and combined analyses were 42.1%, 76.9%, and 89.5%, respectively. All of the 10 contralateral breast cancers were determined to be non-clonal. In contrast, 3 out of 8 (37.5%) of the ipsilateral secondary tumours shared a clonal origin with the primary tumour and were classified as true recurrences, whereas 4 out of 8 (50%) were classified as new primary tumours.Conclusion: GAMDDL analysis represents a novel and useful molecular method for examining the precise cell lineages of primary and secondary tumours, and was more accurate than HUMARA in determining clonality. [ABSTRACT FROM AUTHOR]

Published
2012
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163. Rapid eye movement sleep behavior disorder in patients with Parkinson's disease: Using rapid eye movement sleep behavior disorder screening questionnaire

Author

Suzuki, K., primary, Miyamoto, T., additional, Miyamoto, M., additional, Watanabe, Y., additional, Suzuki, S., additional, Tatsumoto, M., additional, Iwanami, M., additional, Sada, T., additional, Kadowaki, T., additional, Numao, A., additional, Hashimoto, K., additional, Sakuta, H., additional, and Hirata, K., additional

Published
2013
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164. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Author

Kanaji, S, Tanaka, Y, Sakata, Y, Takeshita, K, Arima, K, Ohta, S, Hansell, EJ, Caffrey, C, Mottram, JC, Lowther, J, Donnelly, S, Stack, C, Kadowaki, T, Yamamoto, K, McKerrow, JH, Dalton, JP, Coombs, GH, Izuhara, K, Kanaji, S, Tanaka, Y, Sakata, Y, Takeshita, K, Arima, K, Ohta, S, Hansell, EJ, Caffrey, C, Mottram, JC, Lowther, J, Donnelly, S, Stack, C, Kadowaki, T, Yamamoto, K, McKerrow, JH, Dalton, JP, Coombs, GH, and Izuhara, K

Abstract

The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development. © 2007 Federation of European Biochemical Societies.

Published
2007

172. Genome Sequence of Pantoea agglomerans Strain IG1

Author

Matsuzawa, T., primary, Mori, K., additional, Kadowaki, T., additional, Shimada, M., additional, Tashiro, K., additional, Kuhara, S., additional, Inagawa, H., additional, Soma, G.-i., additional, and Takegawa, K., additional

Published
2012
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178. P1-530 Blood pressure categories and long-term mortality risk of total and components of cardiovascular diseases among Japanese: a 24 year follow-up of representative Japanese (NIPPON DATA80)

Author

Takashima, N., primary, Miura, K., additional, Ohkubo, T., additional, Okamura, T., additional, Turin, T. C., additional, Murakami, Y., additional, Okuda, N., additional, Fujiyoshi, A., additional, Kadowaki, T., additional, Nagasawa, S., additional, Kadota, A., additional, Kita, Y., additional, Okayama, A., additional, and Ueshima, H., additional

Published
2011
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184. Immunohistochemical detection of alpha-catenin expression in human cancers

Author

Shiozaki, H., Iihara, K., Oka, H., Kadowaki, T., Matsui, S., Gofuku, J., Inoue, M., Nagafuchi, A., Tsukita, S., and Mori, T.

Subjects
Adult, Male, Esophageal Neoplasms, Down-Regulation, Infant, Adenocarcinoma, Middle Aged, Cadherins, Immunoenzyme Techniques, Cytoskeletal Proteins, Stomach Neoplasms, Colonic Neoplasms, Carcinoma, Squamous Cell, Humans, Female, alpha Catenin, Research Article, Aged, Neoplasm Staging
Abstract

The function of E-cadherin is thought to be regulated by its associated cytoplasmic proteins including alpha-catenin. To determine whether possible downregulation of alpha-catenin expression may play a role in tumor invasion and metastasis through the dysfunction of E-cadherin, we investigated the expression of alpha-catenin in human carcinoma samples (esophagus, stomach, and colon) by immunohistochemistry using our monoclonal antibody against alpha-catenin (alpha-18). Normal epithelium expressed alpha-catenin strongly without exception. However, alpha-catenin expression was frequently reduced in primary tumors of esophagus (12 of 15:80%), stomach (14 of 20: 70%), and colon (8 of 10: 80%). Of the tumors with reduced alpha-catenin expression, alpha-catenin expression was completely negative in 70.6% of them (9 of 12 in esophagus, 9 of 14 in stomach, and 6 of 8 in colon). These results also suggested that some human cancer cells may have impaired E-cadherin-mediated cell adhesiveness through the downregulation of alpha-catenin expression.

Published
1994

191. Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice

Author

Hashimoto, H., primary, Arai, T., additional, Mori, A., additional, Kawai, K., additional, Hikishima, K., additional, Ohnishi, Y., additional, Eto, T., additional, Ito, M., additional, Hioki, K., additional, Suzuki, R., additional, Ohsugi, M., additional, Saito, M., additional, Ueyama, Y., additional, Okano, H., additional, Yamauchi, T., additional, Kubota, N., additional, Ueki, K., additional, Tobe, K., additional, Tamaoki, N., additional, Kadowaki, T., additional, and Kosaka, K., additional

Published
2009
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