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152. SCN8A encephalopathy: Research progress and prospects

Author

Meisler, Miriam H., primary, Helman, Guy, additional, Hammer, Michael F., additional, Fureman, Brandy E., additional, Gaillard, William D., additional, Goldin, Alan L., additional, Hirose, Shinichi, additional, Ishii, Atsushi, additional, Kroner, Barbara L., additional, Lossin, Christoph, additional, Mefford, Heather C., additional, Parent, Jack M., additional, Patel, Manoj, additional, Schreiber, John, additional, Stewart, Randall, additional, Whittemore, Vicky, additional, Wilcox, Karen, additional, Wagnon, Jacy L, additional, Pearl, Phillip L., additional, Vanderver, Adeline, additional, and Scheffer, Ingrid E., additional

Published
2016
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153. Transdisciplinary co-design of scientific research agendas: 40 research questions for socially relevant climate engineering research

Author

Sugiyama, Masahiro, primary, Asayama, Shinichiro, additional, Kosugi, Takanobu, additional, Ishii, Atsushi, additional, Emori, Seita, additional, Adachi, Jiro, additional, Akimoto, Keigo, additional, Fujiwara, Masatomo, additional, Hasegawa, Tomoko, additional, Hibi, Yasushi, additional, Hirata, Kimiko, additional, Ishii, Toru, additional, Kaburagi, Takeshi, additional, Kita, Yuki, additional, Kobayashi, Shigeki, additional, Kurosawa, Atsushi, additional, Kuwata, Manabu, additional, Masuda, Kooiti, additional, Mitsui, Makoto, additional, Miyata, Taku, additional, Mizutani, Hiroshi, additional, Nakayama, Sumie, additional, Oyamada, Kazuyo, additional, Sashida, Takaaki, additional, Sekiguchi, Miho, additional, Takahashi, Kiyoshi, additional, Takamura, Yukari, additional, Taki, Junichi, additional, Taniguchi, Taketoshi, additional, Tezuka, Hiroyuki, additional, Ueno, Takahiro, additional, Watanabe, Shingo, additional, Watanabe, Rie, additional, Yamagishi, Naoyuki, additional, and Yoshizawa, Go, additional

Published
2016
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155. Present Status of the Compact ERL at KEK

Author

Nakamura, Norio, Adachi, Masahiro, Adachi, Shin-Ichi, Akemoto, Mitsuo, Arakawa, Dai, Asaoka, Seiji, Cenni, Enrico, Enami, Kazuhiro, Endo, Kuninori, Fukuda, Shigeki, Furuya, Takaaki, Haga, Kaiichi, Hajima, Ryoichi, Hara, Kazufumi, Harada, Kentaro, Honda, Tohru, Honda, Yosuke, Honma, Hiroyuki, Honma, Teruya, Hosoyama, Kenji, Hozumi, Ken-Ichi, Hwang, Ji-Gwang, Ishii, Atsushi, Kako, Eiji, Kamiya, Yukihide, Katagiri, Hiroaki, Kawata, Hiroshi, Kobayashi, Yukinori, Kojima, Yuuji, Kondou, Yoshinari, Kume, Tatsuya, Kuriki, Masao, Matsuba, Shunya, Matsumoto, Toshihiro, Matsumura, Hiroshi, Matsushita, Hideki, Michizono, Shinichiro, Miura, Takako, Miyajima, Tsukasa, Miyauchi, Hiroshi, Nagahashi, Shinya, Nagai, Ryoji, Nakai, Hirotaka, Nakajima, Hiromitsu, Nakanishi, Kota, Nakao, Katsumi, Nigorikawa, Kazuyuki, Nishimori, Nobuyuki, Nogami, Takashi, Noguchi, Shuichi, Nozawa, Shunsuke, Obina, Takashi, Ozaki, Toshiyuki, Qiu, Feng, Sagehashi, Hidenori, Sakai, Hiroshi, Sakanaka, Shogo, Sasaki, Shinichi, Satoh, Kotaro, Satoh, Masato, Sawamura, Masaru, Seimiya, Yuji, Shidara, Tetsuo, Shimada, Miho, Shinoe, Kenji, Shioya, Tatsuro, Shishido, Toshio, Shizuma, Toshiyuki, Tadano, Mikito, Tahara, Toshihiro, Takahashi, Takeshi, Takai, Ryota, Takaki, Hiroyuki, Takenaka, Tateru, Tanaka, Olga, Tanimoto, Yasunori, Tobiyama, Makoto, Tsuchiya, Kimichika, Uchiyama, Takashi, Ueda, Akira, Umemori, Kensei, Watanabe, Ken, Yamamoto, Masahiro, Yamamoto, Yasuchika, Yano, Yoshiharu, and Yoshida, Mitsuhiro

Subjects
A18 Energy Recovery Linacs (ERLs), 02 Synchrotron Light Sources and FELs, Accelerator Physics
Abstract

The Compact Energy Recovery Linac (cERL) project is ongoing at KEK in order to demonstrate excellent ERL performance as a future light source. The cERL injector was already constructed with its diagnostic beamline and successfully commissioned from April to June in 2013. In the next step, the cERL recirculation loop with a main superconducting linac and merger and dump sections has been constructed and its commissioning is scheduled to start in December 2013. Significant progress is expected by the IPAC14 conference date. In this presentation, we will describe the present status of the cERL including future developments., Proceedings of the 5th Int. Particle Accelerator Conf., IPAC2014, Dresden, Germany

Published
2014
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156. The First Beam Recirculation and Beam Tuning in the Compact ERL at KEK

Author

Sakanaka, Shogo, Adachi, Masahiro, Adachi, Shin-ichi, Akemoto, Mitsuo, Arakawa, Dai, Asaoka, Seiji, Enami, Kazuhiro, Endo, Kuninori, Fukuda, Shigeki, Furuya, Takaaki, Haga, Kaiichi, Hara, Kazufumi, Harada, Kentaro, Honda, Tohru, Honda, Yosuke, Honma, Hiroyuki, Honma, Teruya, Hosoyama, Kenji, Hozumi, Ken-ichi, Ishii, Atsushi, Jin, Xiuguang, Kako, Eiji, Kamiya, Yukihide, Katagiri, Hiroaki, Kawata, Hiroshi, Kobayashi, Yukinori, Kojima, Yuuji, Kondou, Yoshinari, Konstantinova, Olga, Kume, Tatsuya, Matsumoto, Toshihiro, Matsumura, Hiroshi, Matsushita, Hideki, Michizono, Shinichiro, Miura, Takako, Miyajima, Tsukasa, Miyauchi, Hiroshi, Nagahashi, Shinya, Nakai, Hirotaka, Nakajima, Hiromitsu, Nakamura, Norio, Nakanishi, Kota, Nakao, Katsumi, Nigorikawa, Kazuyuki, Nogami, Takashi, Noguchi, Shuichi, Nozawa, Shunsuke, Obina, Takashi, Ozaki, Toshiyuki, Qiu, Feng, Sagehashi, Hidenori, Sakai, Hiroshi, Sasaki, Shinichi, Satoh, Kotaro, Satoh, Masato, Shidara, Tetsuo, Shimada, Miho, Shinoe, Kenji, Shioya, Tatsuro, Shishido, Toshio, Tadano, Mikito, Tahara, Toshihiro, Takahashi, Takeshi, Takai, Ryota, Takaki, Hiroyuki, Takenaka, Tateru, Tanimoto, Yasunori, Tobiyama, Makoto, Tsuchiya, Kimichika, Uchiyama, Takashi, Ueda, Akira, Umemori, Kensei, Watanabe, Ken, Yamamoto, Masahiro, Yamamoto, Yasuchika, Yano, Yoshiharu, Yoshida, Mitsuhiro, Cenni, Enrico, Hajima, Ryoichi, Matsuba, Shunya, Nagai, Ryoji, Nishimori, Nobuyuki, Sawamura, Masaru, Shizuma, Toshiyuki, Hwang, Ji-Gwang, Kuriki, Masao, Seimiya, Yuji, and Valloni, Alessandra

Subjects
Accelerators and Storage Rings
Abstract

Superconducting(SC)-linac-based light sources, which can produce ultra-brilliant photon beams in CW operation, are attracting worldwide attention. In KEK, we have been conducting R&D; efforts towards the energy-recovery-linac(ERL)-based light source* since 2006. To demonstrate the key technologies for the ERL, we constructed the Compact ERL (cERL)** from 2009 to 2013. In the cERL, high-brightness CW electron beams are produced using a 500-kV photocathode DC gun. The beams are accelerated using SC cavities, transported through a recirculation loop, decelerated in the SC cavities, and dumped. In the February of 2014, we succeeded in accelerating and recirculating the CW beams of 4.5 micro-amperes in the cERL; the beams were successfully transported from the gun to the beam dump under energy recovery operation in the main linac. Then, precise tuning of beam optics and diagnostics of beam properties are under way. We report our experience on the beam commissioning, as well as the results of initial measurements of beam properties.

Published
2014

157. メコンデルタにおける作付体系の変化 : 水利改良との関係を中心に

Author

De, Nguen Ngoc, Ishii, Atsushi, Ohara, Kotaro, and Tsuda, Makoto

Subjects
Mehong Delta, wet direct seeding, facilities of irrigation and drainage, irrigation association, cropping patterns, triple rice cropping, high yielding variety rice
Abstract

Recently in the Mekong Delta, cropping patterns changed from single rice cropping to 1) double or triple rice cropping, 2) paddy rice and upland cropping, and 3) fruit plantation. We investigated 12 farms and villages in this area in order to make clear how changes of cropping patterns were caused by developments of irrigation and drainage. Main findings are as follows ; 1.Double or triple rice cropping were made possible by using high yielding variety rice (HYV) and wet direct seeding (WDS) system. To take this new system, it's necessary to provide paddy fields with sufficient irrigation water in dry season, shorten the inundation period in rainy season and control water depth of paddy field. They were made possible by the developments of irrigation and drainage, which includes 1) construction and rehabilitation of facilities such as canals, embankment and pumps, 2) operation and maintenance of these facilities by production group (farmer's irrigation association). 2.Upland crops and fruit plantation were also made possible by the developments of irrigation and drainage, mainly flood protection in rainy season and control of ground water level., 近年，メコンデルタでは，作系がかつての稲一期作から，1）稲の二期作・三期作，2）稲作＋畑作物，3）果樹作，といったものに変化してきている。そこで，筆者らは，こうした作系の変化が，灌漑・排水の整備こよってどのように発生したかを明らかにするため，この地域における12カ所の農家と集落を調査した。明らかになったのは以下の点である。1．稲の二期作・三期作は，稲の高収量性品種（HYV）を用いた湿潤直播（WDS）を行うことで可能になった。この新しい稲作システムを行うためには，乾季に十分な灌漑用水を供給すること，雨季の洪水期間が短くなるようにすること，そして稲作期間中の水田の水位を制御することが必要である。これらは，1）水路，堤防，ポンプといった水利施設の建設・改修，2）これらの水利施設の生産組織（農民で構成された水利組織による操作と維持管理，といった漕漑・排水の整備によって可能になった。2．畑作物や果樹作も灌漑・排水の整備によって可能になった。この整備は，主として雨季の洪水対策と地下水位の制御である。

Published
1997

158. Domestic sources of international fisheries diplomacy: A framework for analysis.

Author

Barkin, J.S., DeSombre, Elizabeth R., Ishii, Atsushi, and Sakaguchi, Isao

Subjects
INTERNATIONAL fishery management, FISH populations, TAYLORISM (Management), FISHERY policy, NONGOVERNMENTAL organizations
Abstract

Many international commercial fish stocks are threatened with depletion; in some cases they are already badly depleted. Through Regional Fisheries Management Organizations (RFMOs), member countries are committed in principle to sustainable and scientific management of these fisheries. However, in practice, national policies toward international fisheries vary greatly across countries, from those that in practice support sustainable management to those that seem implicitly committed to fishing as much as possible in the short term. There has to this point been little comparative work looking systematically at the differences in international fisheries policies across countries, despite the importance to the effective management of international fisheries of understanding these differences. This article is an effort to address this lacuna in the literature, by creating a framework for comparing the domestic sources of differing international fisheries policies across countries. The proposed analytical framework looks at four types of differences across countries to explain variation in international fisheries policies, derived from the existing literature: fleet substitutability, the structure of the fishing industry in a state, regulatory capture, and environmental NGOs. The framework has significant potential to explain state positions in RFMOs negotiations. It may also contribute to further understanding of the general relationship between international negotiations and domestic politics. [ABSTRACT FROM AUTHOR]

Published
2018
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159. Somatic mosaic deletions involving <italic>SCN1A</italic> cause Dravet syndrome.

Author

Nakayama, Tojo, Ishii, Atsushi, Yoshida, Takeshi, Nasu, Hirosato, Shimojima, Keiko, Yamamoto, Toshiyuki, Kure, Shigeo, and Hirose, Shinichi

Abstract

Somatic mosaicism in single nucleotide variants of SCN1A is known to occur in a subset of parents of children with Dravet syndrome (DS). Here, we report recurrent somatic mosaic microdeletions involving SCN1A in children diagnosed with DS. Through the evaluation of 237 affected individuals with DS who did not show SCN1A or PCHD19 mutations in prior sequencing analyzes, we identified two children with mosaic microdeletions covering the entire SCN1A region. The allele frequency of the mosaic deletions estimated by multiplex ligation‐dependent probe amplification and array comparative genomic hybridization was 25–40%, which was comparable to the mosaic ratio in lymphocytes and buccal mucosa cells observed by fluorescence in situ hybridization analysis. The minimal prevalence of SCN1A mosaic deletion is estimated to be 0.9% (95% confidence level: 0.11–3.11%) of DS with negative for SCN1A and PCDH19 mutations. This study reinforces the importance of somatic mosaicism caused by copy number variations in disease‐causing genes, and provides an alternative spectrum of SCN1A mutations causative of DS. Somatic deletions in SCN1A should be considered in cases with DS when standard screenings for SCN1A mutations are apparently negative for mutations. [ABSTRACT FROM AUTHOR]

Published
2018
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161. Radiolarian Assemblage-zones in the Jurassic and Cretaceous Sequence in the Kanto Mountains, Central Japan

Author

Takahashi, Osamu and Ishii, Atsushi

Abstract

Nineteen radiolarian assemblage-zones have been established in the Jurassic to Cretaceous sequences in the Kanto Mountains, central Japan. They consist of the Parahsuum simplum (Hettangian - Pliensbachian), Parvicingula gigantocornis (Toarcian), Hsuum hisuikyoense (Aalenian), Unuma echinatus (early – middle Bajocian), Dictyomitrella(?) kamoensis (emended herein: late Bajocian – early Bathonian), Guexella nudata (emended herein: middle - late Bathonian), Mirifusus guadalupensis (emended herein: early Callovian), Stylocapsa(?) spiralis (newly defined: late Callovian – early Oxfordian), Tricolocapsa yaoi (middle – late Oxfordian), Pseudodictyomitra primitiva (Kimmeridgian – middle Tithonian), Pseudodictyomitra carpatica (late Tithonian – early Valanginian), Sethocapsa uterculus (emended herein: Valanginian), Eucyrtis tenus (emended herein: Hauterivian – early Barremian), Thanarla conica (newly defined: Barremian), Holocryptocanium barbui (late Albian – Cenomanian), Dictyomitra Formosa (newly defined: Coniacian – Santonian), Amphipyndax enesseffi (emended herein: early – middle Campanian), Amphipyndax tylotus (late Campanian – early Maastrichtian), and Clathrocyclas(?) gravis (emended herein: Maastrichtian) Assemblage-zones in ascending order. As a result, significant stratigraphic gaps are recognized in the Aptian – Middle Albian and the Turonian. It is noteworthy that these mid-Cretaceous time-stratigraphic hiatuses are widely observed not only in the Kanto Mountains but also in the Outer Zone of Southwest Japan. These stratigraphic gaps may be ascribed to the global mass extinctions and the deteriorated accretion or accretionary hiatus due to the change of movement directions of subducting Plates.

Published
1995

171. Clinical and genetic features of acute encephalopathy in children taking theophylline

Author

Saitoh, Makiko, primary, Shinohara, Mayu, additional, Ishii, Atsushi, additional, Ihara, Yukiko, additional, Hirose, Shinichi, additional, Shiomi, Masashi, additional, Kawawaki, Hisashi, additional, Kubota, Masaya, additional, Yamagata, Takanori, additional, Miyamoto, Akie, additional, Yamanaka, Gaku, additional, Amemiya, Kaoru, additional, Kikuchi, Kenjiro, additional, Kamei, Atsushi, additional, Akasaka, Manami, additional, Anzai, Yuki, additional, and Mizuguchi, Masashi, additional

Published
2015
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172. Single Nucleotide Variations in CLCN6 Identified in Patients with Benign Partial Epilepsies in Infancy and/or Febrile Seizures

Author

Yamamoto, Toshiyuki, primary, Shimojima, Keiko, additional, Sangu, Noriko, additional, Komoike, Yuta, additional, Ishii, Atsushi, additional, Abe, Shinpei, additional, Yamashita, Shintaro, additional, Imai, Katsumi, additional, Kubota, Tetsuo, additional, Fukasawa, Tatsuya, additional, Okanishi, Tohru, additional, Enoki, Hideo, additional, Tanabe, Takuya, additional, Saito, Akira, additional, Furukawa, Toru, additional, Shimizu, Toshiaki, additional, Milligan, Carol J., additional, Petrou, Steven, additional, Heron, Sarah E., additional, Dibbens, Leanne M., additional, Hirose, Shinichi, additional, and Okumura, Akihisa, additional

Published
2015
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173. Power Coupler Development for ERL Main LINAC in Japan

Author

Sakai, Hiroshi, Furuya, Takaaki, Ishii, Atsushi, Nakamura, Norio, Sakanaka, Shogo, Sawamura, Masaru, Shinoe, Kenji, Takahashi, Takeshi, and Umemori, Kensei

Subjects
T07 Superconducting RF, 07 Accelerator Technology, Accelerator Physics
Abstract

We started to develop an input power coupler for a 1.3GHz ERL superconducting cavity for ERL main linac. Required input power is about 20kW for the cavity acceleration field of 20MV/m and the beam current of 100mA in energy recovery operation. The input coupler is designed based on the STF-BL input coupler, especially choke-mode type ceramic window was applied. After that some modifications are applied for the CW 20kW power operation. We fabricated input coupler components such as ceramic windows and bellows and carried out the high-power test of the components by using a 30kW IOT power source and a test stand constructed., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

Published
2010
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176. Different links with the same Links-Gould invariant

Author

Ishii, Atsushi and Kanenobu, Taizo

Subjects
Mathematics::Quantum Algebra, Mathematics::Geometric Topology
Abstract

Using the skein relations for the Links-Gould (LG) invariant discovered by the first author, we give two constructions to provide a pair of different knots or links sharing the same LG invariant. Using this, we give examples of arbitrarily many 2-bridge knots with the same LG invariant. These knots also share the same HOMFLY and Kauffman polynomials. Further, for 2-bridge links we construct a similar example, which also share the same 2-variable Alexander polynomial. We also give a non-amphicheiral hyperbolic knot whose chirality is not undetected by the LG invariant.

Published
2005

178. The g.841G>C SNP ofFASNgene is associated with fatty acid composition in beef cattle

Author

Hayakawa, Kiri, primary, Sakamoto, Takayuki, additional, Ishii, Atsushi, additional, Yamaji, Keita, additional, Uemoto, Yoshinobu, additional, Sasago, Nanae, additional, Kobayashi, Eiji, additional, Kobayashi, Naohiko, additional, Matsuhashi, Tamako, additional, Maruyama, Shin, additional, Matsumoto, Hirokazu, additional, Oyama, Kenji, additional, Mannen, Hideyuki, additional, and Sasazaki, Shinji, additional

Published
2015
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181. バングラデシュにおける河川堤防の機能と保全に関する調査研究

Author

三重大学大学院生物資源学研究科, SAKAI, Toshinori, HOSSAIN, Zakaria, NARIOKA, Hajime, KAJISA, Takamitsu, ISHII, Atsushi, KONDO, Masaaki, 酒井, 俊典, 保世院, 座狩屋, 成岡, 市, 加治佐, 隆光, 石井, 敦, 近藤, 雅秋, 三重大学大学院生物資源学研究科, SAKAI, Toshinori, HOSSAIN, Zakaria, NARIOKA, Hajime, KAJISA, Takamitsu, ISHII, Atsushi, KONDO, Masaaki, 酒井, 俊典, 保世院, 座狩屋, 成岡, 市, 加治佐, 隆光, 石井, 敦, and 近藤, 雅秋

Abstract

平成19~22年度科学研究費補助金(基盤研究(B))研究成果報告書, バングラデシュのシラジホンジュ市、マニクゴンジュ市、ラジシャヒ市の道路堤防、ジャムナ川、パッダ川、マヌ川の河川堤防を訪問の際には堤防破壊に関する現地調査、情報収集と共に、現場から土を採取し、基本的物理性試験および締固め試験、透水試験、一軸圧縮試験、三軸圧縮試験等のせん断試験などによって土質性状を求めた。解析によって各地区におけるパラメータ特性の評価行った。ラジシャヒ市ゴダガリ地区の盛土堤防法面保護における実証実験を行い、現地に適した経済的に安価で土砂災害に強い盛土堤防を作り上げる新工法を提案した。Performance and maintenance of road embankments in Sirajgonj district, Manikgonj district, Rajshahi district, Jamuna river embankment, Padma river embankment and Manu river embankment were studied. Soil samples from the failure locations were collected during filed visit. Soil properties were determined by laboratory tests such as compaction tests, unconfined compression tests, triaxial tests and direct shear tests etc. Analytical investigations were performed to evaluate the soil parameters of the damaged areas. Field experiments for slope protection at Godagari Upazilla in Rajshahi district were carried out by using a new composite technology. Results of fields tests, laboratory tests and analyses indicated that the new composite technology is not only economical and strong for slope protection but also viable and appropriate in Bangladesh.

Published
2014

187. Genotype–phenotype correlations in alternating hemiplegia of childhood

Author

Sasaki, Masayuki, primary, Ishii, Atsushi, additional, Saito, Yoshiaki, additional, Morisada, Naoya, additional, Iijima, Kazumoto, additional, Takada, Satoshi, additional, Araki, Atsushi, additional, Tanabe, Yuko, additional, Arai, Hidee, additional, Yamashita, Sumimasa, additional, Ohashi, Tsukasa, additional, Oda, Yoichiro, additional, Ichiseki, Hiroshi, additional, Hirabayashi, Shininchi, additional, Yasuhara, Akihiro, additional, Kawawaki, Hisashi, additional, Kimura, Sadami, additional, Shimono, Masayuki, additional, Narumiya, Seiro, additional, Suzuki, Motomasa, additional, Yoshida, Takeshi, additional, Oyazato, Yoshinobu, additional, Tsuneishi, Shuichi, additional, Ozasa, Shiro, additional, Yokochi, Kenji, additional, Dejima, Sunao, additional, Akiyama, Tomoyuki, additional, Kishi, Nobuyuki, additional, Kira, Ryutaro, additional, Ikeda, Toshio, additional, Oguni, Hirokazu, additional, Zhang, Bo, additional, Tsuji, Shoji, additional, and Hirose, Shinichi, additional

Published
2014
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190. Insights from Global Environmental Governance

Author

Trudeau, Hélène, additional, Duplessis, Isabelle, additional, Lalonde, Suzanne, additional, Van de Graaf, Thijs, additional, De Ville, Ferdi, additional, O'Neill, Kate, additional, Roger, Charles, additional, Dauvergne, Peter, additional, Morin, Jean-Frédéric, additional, Oberthür, Sebastian, additional, Orsini, Amandine, additional, Biermann, Frank, additional, Ohta, Hiroshi, additional, and Ishii, Atsushi, additional

Published
2013
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193. Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choreoathetosis syndrome, and benign convulsions with mild gastroenteritis

Author

Ishii, Atsushi, primary, Yasumoto, Sawa, additional, Ihara, Yukiko, additional, Inoue, Takahito, additional, Fujita, Takako, additional, Nakamura, Noriko, additional, Ohfu, Masaharu, additional, Yamashita, Yushiro, additional, Takatsuka, Hideo, additional, Taga, Toshiaki, additional, Miyata, Rie, additional, Ito, Masahiro, additional, Tsuchiya, Hiroshi, additional, Matsuoka, Taro, additional, Kitao, Tetsuya, additional, Murakami, Kiyotaka, additional, Lee, Wang-Tso, additional, Kaneko, Sunao, additional, and Hirose, Shinichi, additional

Published
2013
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197. メコンデルタにおける作付体系の変化 : 水利改良との関係を中心に

Author

三重大学生物資源学部, カントー大学, Faculty of Bioresources, Mie University, FSRD, Cantho University, Ishii, Atsushi, Ohara, Kotaro, Tsuda, Makoto, 石井, 敦, 大原, 興太郎, 津田, 誠, De, Nguen Ngoc, 三重大学生物資源学部, カントー大学, Faculty of Bioresources, Mie University, FSRD, Cantho University, Ishii, Atsushi, Ohara, Kotaro, Tsuda, Makoto, 石井, 敦, 大原, 興太郎, 津田, 誠, and De, Nguen Ngoc

Abstract

Recently in the Mekong Delta, cropping patterns changed from single rice cropping to 1) double or triple rice cropping, 2) paddy rice and upland cropping, and 3) fruit plantation. We investigated 12 farms and villages in this area in order to make clear how changes of cropping patterns were caused by developments of irrigation and drainage. Main findings are as follows ; 1.Double or triple rice cropping were made possible by using high yielding variety rice (HYV) and wet direct seeding (WDS) system. To take this new system, it's necessary to provide paddy fields with sufficient irrigation water in dry season, shorten the inundation period in rainy season and control water depth of paddy field. They were made possible by the developments of irrigation and drainage, which includes 1) construction and rehabilitation of facilities such as canals, embankment and pumps, 2) operation and maintenance of these facilities by production group (farmer's irrigation association). 2.Upland crops and fruit plantation were also made possible by the developments of irrigation and drainage, mainly flood protection in rainy season and control of ground water level., 近年，メコンデルタでは，作系がかつての稲一期作から，1）稲の二期作・三期作，2）稲作＋畑作物，3）果樹作， といったものに変化してきている。そこで，筆者らは，こうした作系の変化が，灌漑・排水の整備こよってどのよう に発生したかを明らかにするため，この地域における12カ所の農家と集落を調査した。明らかになったのは以下の 点である。 1．稲の二期作・三期作は，稲の高収量性品種（HYV）を用いた湿潤直播（WDS）を行うことで可能になった。 この新しい稲作システムを行うためには，乾季に十分な灌漑用水を供給すること，雨季の洪水期間が短くなるように すること，そして稲作期間中の水田の水位を制御することが必要である。これらは，1）水路，堤防，ポンプといっ た水利施設の建設・改修，2）これらの水利施設の生産組織（農民で構成された水利組織による操作と維持管理， といった漕漑・排水の整備によって可能になった。 2．畑作物や果樹作も灌漑・排水の整備によって可能になった。この整備は，主として雨季の洪水対策と地下水位の 制御である。

Published
2007

198. A pH sensor based on electric properties of nanotubes on a glass substrate

Author

Takeda, Seiji, Nakamura, Motonori, Ishii, Atsushi, Subagyo, Agus, Hosoi, Hirotaka, Sueoka, Kazuhisa, Mukasa, Koichi, Takeda, Seiji, Nakamura, Motonori, Ishii, Atsushi, Subagyo, Agus, Hosoi, Hirotaka, Sueoka, Kazuhisa, and Mukasa, Koichi

Abstract

We fabricated a pH-sensitive device on a glass substrate based on properties of carbon nanotubes. Nanotubes were immobilized specifically on chemically modified areas on a substrate followed by deposition of metallic source and drain electrodes on the area. Some nanotubes connected the source and drain electrodes. A top gate electrode was fabricated on an insulating layer of silane coupling agent on the nanotube. The device showed properties of an n-type field effect transistor when a potential was applied to the nanotube from the top gate electrode. Before fabrication of the insulating layer, the device showed that the p-type field effect transistor and the current through the source and drain electrodes depend on the buffer pH. The current increases with decreasing pH of the CNT solution. This device, which can detect pH, is applicable for use as a biosensor through modification of the CNT surface.

Published
2007

199. Ultrasensitive detection of organophosphate insecticides by carbon nanotube field-effect transistor

Author

Ishii, Atsushi, Takeda, Seiji, Hattori, Satoshi, Sueoka, Kazuhisa, Mukasa, Koichi, Ishii, Atsushi, Takeda, Seiji, Hattori, Satoshi, Sueoka, Kazuhisa, and Mukasa, Koichi

Abstract

Carbon nanotube sensors were capable of detecting organophosphate insecticide binding to recombinant acetylcholinesterase (rAChE) immobilized on the sensor. The carbon nanotube sensors were fabricated by chemical vapor deposition method and it showed field-effect transistor property. rAChE was immobilized by specific binding of NTA-Ni and His tag on the reverse side of the carbon nanotube sensor. The current between the source and drain was measured after incubation of various concentrations of organophosphates with immobilized rAChE. I-ds-V-gate curves were obtained by plotting the current as a function of the potential applied to the back gate. The I-ds-V-gate curves showed a positive shift in a dose dependent manner, while no shifts were observed when an herbicide was added to the sensor and organophosphates were withdrawn on recombinant calmodulin immobilized surface. In spite of different inhibition effects, two organophosphates showed similar dose response curves in measuring I-ds-V-gate correlation with the rAChE-immobilized CNT sensors, suggesting that the binding of organophosphates to rAChE may be sequestered from the inhibition activity of those to the enzyme.

Published
2007

200. Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.

Author

Ishii, Atsushi, Watkins, Joseph C., Chen, Debbie, Hirose, Shinichi, and Hammer, Michael F.

Subjects
*MISSENSE mutation, *DISEASE incidence, *PEOPLE with disabilities, *EPILEPSY, *SEIZURES (Medicine)
Abstract

Objective Two major classes of SCN1A variants are associated with Dravet syndrome ( DS): those that result in haploinsufficiency (truncating) and those that result in an amino acid substitution (missense). The aim of this retrospective study was to describe the first large cohort of Japanese patients with SCN1A mutation-positive DS (n = 285), and investigate the relationship between variant (type and position) and clinical expression and response to treatment. Methods We sequenced all exons and intron-exon boundaries of SCN1A in our cohort, investigated differences in the distribution of truncating and missense variants, tested for associations between variant type and phenotype, and compared these patterns with those of cohorts with milder epilepsy and healthy individuals. Results Unlike truncation variants, missense variants are found at higher density in the S4 voltage sensor and pore loops and at lower density in the domain I- II and II- III linkers and the first three segments of domain II. Relative to healthy individuals, there is an increased frequency of truncating (but not missense) variants in the noncoding C-terminus. The rate of cognitive decline is more rapid for patients with truncation variants regardless of age at seizure onset, whereas age at onset is a predictor of the rate of cognitive decline for patients with missense variants. Significance We found significant differences in the distribution of truncating and missense variants across the SCN1A sequence among healthy individuals, patients with DS, and those with milder forms of SCN1A-variant positive epilepsy. Testing for associations with phenotype revealed that variant type can be predictive of rate of cognitive decline. Analysis of descriptive medication data suggests that in addition to conventional drug therapy in DS, bromide, clonazepam and topiramate may reduce seizure frequency. [ABSTRACT FROM AUTHOR]

Published
2017
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