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2,248 results on '"I, Simon"'

151. Machine Learning Algorithms for Prediction of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement

Author

Takahiro Tsushima, Mauricio Arruda, Judith A. Mackall, Marco A. Costa, Sadeer G. Al-Kindi, Alan H. Markowitz, Guilherme F. Attizzani, Sergio G. Thal, Daniel I. Simon, Fahd Nadeem, and Yakov Elgudin

Subjects
medicine.medical_specialty, Pacemaker, Artificial, Transcatheter aortic, medicine.medical_treatment, Action Potentials, Risk Assessment, Decision Support Techniques, Machine Learning, Transcatheter Aortic Valve Replacement, Valve replacement, Heart Rate, Predictive Value of Tests, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, Prospective Studies, Atrioventricular Block, Retrospective Studies, business.industry, Cardiac Pacing, Artificial, medicine.disease, Treatment Outcome, Aortic Valve, Cardiology, Permanent pacemaker, Cardiology and Cardiovascular Medicine, business, Atrioventricular block
Published
2021

152. Starting and Operating a Public Cardiac Catheterization Laboratory in a Low Resource Setting: The Eight-Year Story of the Uganda Heart Institute Catheter Laboratory

Author

Brian Kiggundu, Wilson Nyakoojo, Joselyn Rwebembera, Kanishka Ratnayaka, Peter Lwabi, Shakeel A. Qureshi, Sanjay Daluvoy, Krishna Kumar, Emmy Okello, James Kayima, John Omagino, Charles Mondo, Sulaiman Lubega, Marco A. Costa, Elias Sebatta, Twalib Aliku, Chris T. Longenecker, Daniel I. Simon, Daudi Kirenzi, and Craig Sable

Subjects
Adult, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiac Catheterization, Catheters, Cath lab, Epidemiology, Low resource, cardiac, medicine.medical_treatment, Population, Psychological intervention, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Uganda, 030212 general & internal medicine, Cardiology, Interventional Cardiology, education, Child, catheterization, Disease burden, LMIC, Africa, Cardiac catheterization, Retrospective Studies, Original Research, Community and Home Care, education.field_of_study, Government, business.industry, lcsh:Public aspects of medicine, lcsh:RA1-1270, medicine.disease, CVD, laboratory, cath lab, Catheter, lcsh:RC666-701, Medical emergency, Cardiology and Cardiovascular Medicine, business, Laboratories
Abstract

Background: Low- and-middle-income-countries (LMICs) currently bear 80% of the world’s cardiovascular disease (CVD) mortality burden. The same countries are underequipped to handle the disease burden due to critical shortage of resources. Functional cardiac catheterization laboratories (cath labs) are central in the diagnosis and management of CVDs. Yet, most LMICs, including Uganda, fall remarkably below the minimum recommended standards of cath lab:population ratio due to a host of factors including the start-up and recurring costs. Objectives: To review the performance, challenges and solutions employed, lessons learned, and projections for the future for a single cath lab that has been serving the Ugandan population of 40 million people in the past eight years. Methods: A retrospective review of the Uganda Heart Institute cath lab clinical database from 15 February 2012 to 31 December 2019 was performed. Results: In the initial two years, this cath lab was dependent on skills transfer camps by visiting expert teams, but currently, Ugandan resident specialists independently operate this lab. 3,542 adult and pediatric procedures were conducted in 8 years, including coronary angiograms and percutaneous coronary interventions, device implantations, valvuloplasties, and cardiac defect closures, among others. There was a consistent expansion of the spectrum of procedures conducted in this cath lab each year. The initial lack of technical expertise and sourcing for equipment, as well as the continual need for sundries present(ed) major roadblocks. Government support and leveraging existing multi-level collaborations has provided a platform for several solutions. Sustainability of cath lab services remains a significant challenge especially in relation to the high cost of sundries and other consumables amidst a limited budget. Conclusion: A practical example of how centers in LMIC can set up and sustain a public cardiac catheterization laboratory is presented. Government support, research, and training collaborations, if present, become invaluable leverage opportunities.

Published
2021

153. Institutions For Mental Diseases Medicaid Waivers: Impact On Payments For Substance Use Treatment Facilities

Author

Johanna Catherine, Maclean, Hefei, Wen, Kosali I, Simon, and Brendan, Saloner

Subjects
Adult, Young Adult, Medicaid, Humans, Federal Government, Middle Aged, Opioid-Related Disorders, United States, Article
Abstract

The Institutions for Mental Diseases (IMD) exclusion prohibits use of federal Medicaid funds to treat enrollees ages 21-64 in psychiatric residential treatment facilities that have more than sixteen beds. In 2015 the federal government created a streamlined application pathway for state waivers of this rule to allow Medicaid coverage for substance use disorder (SUD) treatment in residential facilities. Nine states received IMD waivers during the period 2015-18. Using data from the 2010-18 National Survey of Substance Abuse Treatment Services, we examined changes in residential and outpatient SUD treatment facilities' acceptance of Medicaid and other types of health coverage, as well as self-pay arrangements and provision of charity care, after states' adoption of IMD waivers. Acceptance of Medicaid increased 34 percent at residential treatment facilities and 9 percent at intensive outpatient facilities two years after waiver implementation. Delivery of medications for opioid use disorder did not increase in residential facilities post waiver but did increase to some extent in outpatient facilities. Our findings suggest that IMD waivers may be an important tool for advancing access to a full continuum of SUD treatment for Medicaid enrollees.

Published
2021

156. Clinical outcomes according to lesion complexity in high bleeding risk patients treated with 1-month dual antiplatelet therapy following PCI: Analysis from the Onyx ONE clear study

Author

Lilian C. Lee, Elvin Kedhi, Robert C. Stoler, Ajay J. Kirtane, James W. Choi, Gregg W. Stone, Stephan Windecker, Alexandre Abizaid, Daniel I. Simon, Martin Hudec, Matthew J. Price, Mihir Kanitkar, Kenji Ando, David E. Kandzari, Azfar Zaman, C.C. Tam, A. Conradie, Azeem Latib, Te Hsin Lung, Stephen G. Worthley, Roxana Mehran, Antony Walton, and Luis Gruberg

Subjects
medicine.medical_specialty, medicine.medical_treatment, Coronary Artery Disease, Atherectomy, Coronary artery disease, Percutaneous Coronary Intervention, Internal medicine, Diabetes mellitus, medicine, Humans, Radiology, Nuclear Medicine and imaging, Myocardial infarction, cardiovascular diseases, 610 Medicine & health, business.industry, Dual Anti-Platelet Therapy, Percutaneous coronary intervention, Stent, Drug-Eluting Stents, General Medicine, medicine.disease, Treatment Outcome, surgical procedures, operative, Conventional PCI, Propensity score matching, Cardiology, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract

OBJECTIVES To compare clinical outcomes in high bleeding risk (HBR) patients with and without complex percutaneous coronary intervention (PCI) treated with Resolute Onyx zotarolimus-eluting stents (ZES) after 1-month dual antiplatelet therapy (DAPT). BACKGROUND PCI with 1-month DAPT has been demonstrated to be safe in HBR patients treated with Resolute Onyx ZES. Whether these outcomes are consistent in patients with complex lesions is uncertain. METHODS Among HBR patients who were event-free 1��month after PCI with ZES and treated thereafter with single antiplatelet therapy (SAPT), the clinical outcomes between 1 month and 1 year were compared after complex PCI (3 vessels treated, ��� 3 lesions treated, total stent length > 60���mm, bifurcation with ��� 2 stents implanted, atherectomy, or left main, surgical bypass graft or chronic total occlusion PCI) versus noncomplex PCI. Propensity score adjustment was performed to adjust for baseline differences among complex and noncomplex patients. RESULTS Complex patients (N��=��401, 26.6% of total) had a higher prevalence of hyperlipidemia, diabetes mellitus and previous myocardial infarction (MI). Between 1 month and 1 year, rates of MI (7.1% vs. 4.0%, p��=��0.02) and cardiac death/MI (9.3% vs. 6.1%, p��=��0.04) were higher among complex versus noncomplex patients, although stent thrombosis rates were similar. After adjustment for baseline characteristics, differences in outcomes were no longer significant between groups. CONCLUSIONS Higher rates of ischemic outcomes in complex PCI patients were largely explained by baseline clinical differences, rather than lesion complexity, among HBR patients treated with 1-month DAPT following PCI with Resolute Onyx ZES.

Published
2021
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158. Pre-Existing and Pragmatically-Derived Immunohematologic Phenotypes Predict All-Cause and COVID-19-Specific Mortality: A 'Population Immunology' Approach

Author

Osnard M, Chung M, Sundaram, Adam T. Perzynski, Chan Ta, Neal V. Dawson, Jarrod E. Dalton, Mukesh K. Jain, Daniel I. Simon, Wass Sy, David A. Zidar, Taissa Bej, Douglas D. Gunzler, Sadeer G. Al-Kindi, Bonomo Ra, Brigid Wilson, Yongmei Liu, Donald D. Anthony, Nguyen At, and Kristen A. Berg

Subjects
medicine.medical_specialty, education.field_of_study, National Health and Nutrition Examination Survey, business.industry, Anemia, Hazard ratio, Population, Disease, medicine.disease, Institutional review board, Internal medicine, Diabetes mellitus, Medicine, Anisocytosis, business, education
Abstract

Background: Dysregulation of immunohematologic function (IHF) promotes cardiovascular disease and impairs protective responses to cancer and infection. A pragmatic method to identify those as risk due to IHF could improve the precision of preventive interventions and provide insight into the heterogeneity of immunologic capacity. We developed and validated a method to distill complete blood cell count data into distinct IHF profiles of prognostic relevance. Methods: We adapted latent profile analysis methods to simultaneously identify distinct groups of patients with respect to 10 immunohematologic indicators and regress time to all-cause mortality on this latent IHF profile. The model was developed using data from 30274 National Health and Nutrition Examination Survey participants and externally validated in 49851 outpatients in the Veterans Heath Administration (VHA) system and 44142 SARS-CoV-2 positive VHA patients. Findings: Ten distinct IHF profiles were identified. Profile 1, with relative mild pan-leukopenia in absence of red cell abnormalities, was associated with the best long term survival in each setting. Profiles 8-10, featuring anemia/anisocytosis especially in the setting of lymphopenia (Profiles 9-10) were associated with adjusted hazard ratio (HR) estimates of 1.76-2.62 for mortality across the three cohorts, compared to Profile 1. Profiles 6-7, featuring relative neutrophilia, were less common but also independently associated with mortality risk, especially after COVID-19 infection (Profile 7 HR [95% CI]: 2.51 [1.63 – 3.86]). The magnitude of adjusted risk conveyed by IHF profiles was greater than individual clinical risk factors (i.e., smoking, diabetes) or prevalent co-morbidities. Interpretation: Distinct immunohematologic endotypes can be identified during routine blood panels which project to mortality risk on par with a decade of life, additive to demographic and clinical factors. Applications that consider immunohematologic dysfunction may improve prevention of common fatal diseases, including COVID-19. Funding Information:This study was funded in part by The National Institute on Aging (R01AG055480; Dalton and Perzynski), the National Cancer Institute (U01CA260513; Zidar and Chan), and the United States Veteran Administration (COVID19-8900-05; Zidar). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veteran Affairs or the National Institutes of Health. Declaration of Interests: No conflict of interest exists between any of the authors and the contents of this paper. Ethics Approval Statement: The study was approved by the Institutional Review Board of the Louis Stokes Cleveland VAMC.

Published
2021
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159. Improving The Computational Efficiency of 3-D Modeling of Induced Polarization in Airborne Time-Domain Electromagnetic Problems

Author

Marina G. Persova, A.S. Kiseleva, Denis V. Vagin, Yu. G. Soloveichik, A.P. Sivenkova, and Evgenia I. Simon

Subjects
Electromagnetic field, Mathematical model, Computer science, Frequency domain, Polygon mesh, Time domain, Degrees of freedom (mechanics), Algorithm, Finite element method, Data processing system
Abstract

Summary The article proposes mathematical models for calculating induced polarization (IP) when solving 3-D airborne time-domain electromagnetic problems. The proposed approaches are optimized directly for solving “multisource” problems for further application in data processing systems. For constructing finite element approximation, we use optimized non-conforming hexahedral meshes allowing to drastically reduce the number of degrees of freedom while keeping the required solution accuracy. In addition, to provide calculations with a large number of positions of the transmitter-receiver set, the space-time grouping of subtasks corresponding to different positions of the airborne system and parallelization were used. We present a comparison of the developed computational schemes that perform calculations both directly in the time domain and in the frequency domain, as well as a comparison with the results of other authors. It is shown that the solutions obtained using different approaches are in good agreement with each other. The computational costs required for calculating the electromagnetic field taking into account the IP effects in a complex 3-D medium with topography are about 10 s per position. This will make it possible to use this approach in the future in systems for processing airborne data.

Published
2021
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161. Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes

Author

Megan J. Liou, Brittany M. Miller, Yael Litvak, Henry Nguyen, Dean E. Natwick, Hannah P. Savage, Jordan A. Rixon, Scott P. Mahan, Hirotaka Hiyoshi, Andrew W.L. Rogers, Eric M. Velazquez, Brian P. Butler, Sean R. Collins, Stephen J. McSorley, Rasika M. Harshey, Mariana X. Byndloss, Scott I. Simon, and Andreas J. Bäumler

Subjects
Salmonella typhimurium, Immunology, nutrient niches, Microbiology, Article, Vaccine Related, Enterobacterales, Salmonella, nitrate, Biodefense, Virology, Escherichia coli, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Humans, chemotaxis, Aetiology, Symbiosis, biogeography, Nitrates, gut microbiota, Prevention, Nutrients, Foodborne Illness, Gastrointestinal Microbiome, Gastrointestinal Tract, Infectious Diseases, Emerging Infectious Diseases, Medical Microbiology, Parasitology, Digestive Diseases, Infection
Abstract

Changes in the microbiota composition are associated with many human diseases, but factors that govern strain abundance remain poorly defined. We show that a commensal Escherichia coli strain and a pathogenic Salmonella enterica serovar Typhimurium isolate both utilize nitrate for intestinal growth, but each accesses this resource in a distinct biogeographical niche. Commensal E.coli utilizes epithelial-derived nitrate, whereas nitrate in the niche occupied by S. Typhimurium is derived from phagocytic infiltrates. Surprisingly, avirulent S. Typhimurium was shown to be unable to utilize epithelial-derived nitrate because its chemotaxis receptors McpB and McpC exclude the pathogen from the niche occupied by E.coli. In contrast, E.coli invades the niche constructed by S. Typhimurium virulence factors and confers colonization resistance by competing for nitrate. Thus, nutrient niches are not defined solely by critical resources, but they can be further subdivided biogeographically within the host into distinct microhabitats, thereby generating new niche opportunities for distinct bacterial species.

Published
2022
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164. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress.

Author

Ying I Wang, Ahmed Bettaieb, Chongxiu Sun, J Sherrod DeVerse, Christopher E Radecke, Steven Mathew, Christina M Edwards, Fawaz G Haj, Anthony G Passerini, and Scott I Simon

Subjects
Medicine, Science
Abstract

Circulating triglyceride-rich lipoproteins (TGRL) from hypertriglyceridemic subjects exacerbate endothelial inflammation and promote monocyte infiltration into the arterial wall. We have recently reported that TGRL isolated from human blood after a high-fat meal can elicit a pro- or anti-atherogenic state in human aortic endothelial cells (HAEC), defined as up- or down-regulation of VCAM-1 expression in response to tumor necrosis factor alpha (TNFα) stimulation, respectively. A direct correlation was found between subjects categorized at higher risk for cardiovascular disease based upon serum triglycerides and postprandial production of TGRL particles that increased VCAM-1-dependent monocyte adhesion to inflamed endothelium. To establish how TGRL metabolism is linked to VCAM-1 regulation, we examined endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) pathways. Regardless of its atherogenicity, the rate and extent of TGRL internalization and lipid droplet formation by HAEC were uniform. However, pro-atherogenic TGRL exacerbated ER membrane expansion and stress following TNFα stimulation, whereas anti-atherogenic TGRL ameliorated such effects. Inhibition of ER stress with a chemical chaperone 4-phenylbutyric acid decreased TNFα-induced VCAM-1 expression and abrogated TGRL's atherogenic effect. Activation of ER stress sensors PKR-like ER-regulated kinase (PERK) and inositol requiring protein 1α (IRE1α), and downstream effectors including eukaryotic initiation factor-2α (eIF2α), spliced X-box-binding protein 1 (sXBP1) and C/EBP homologous protein (CHOP), directly correlated with the atherogenic activity of an individual's TGRL. Modulation of ER stress sensors also correlated with changes in expression of interferon regulatory factor 1 (IRF-1), a transcription factor of Vcam-1 responsible for regulation of its expression. Moreover, knockdown studies using siRNA defined a causal relationship between the PERK/eIF2α/CHOP pathway and IRF-1-mediated VCAM-1 expression. We conclude that ER stress and the UPR contribute to the regulation of Vcam-1 transcription as a function of the atherogenic nature of TGRL.

Published
2013
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165. The Impacts of Implementing Primary Care Indicators and Related Financial Incentives on the Trends of Vaccination Coverage Against Influenza Among Elderly People in Hungary

Author

Ala’a B. Al-Tammemi, Nándor Dr.Balogh, László Dr. Kolozsvári, I Simon, Gergő József Szőllősi, Szilvia Harsányi, and Szabolcs Garbóczy

Subjects
Financial incentives, Environmental health, Vaccination coverage, Elderly people, Business, Primary care
Abstract

Background Influenza is considered one of the most important global public health issues, and a main contributing factor to significant mortality and morbidity across many countries worldwide, especially among elderlies. This study aimed to evaluate the changes of flu vaccination coverage among elderlies in Hungary over the past years and to analyze the effect of implementing financial incentive related primary care indicators on the vaccination coverage.Methods 95% Confidence intervals for proportions of people aged 65 or above regarding influenza vaccination status were calculated yearly in order to detect the trends of vaccination coverage in Hungary before and after an 8-year period of the introduction of indicators system.Results Despite the financial motivational incentives provided to general practitioners to vaccinate their patients against influenza, the vaccination coverage is declining in recent years i.e. before the implementation: 36.01% (95% CI: 35.98 – 36.04); after the implementation: 28.03% (95% CI : 28.01 - 28.06).Conclusions According to our results, the implementation of indicators system and related financial incentives could not exploit the potential opportunities in the aspect of increasing the flu vaccination coverage among elderlies in Hungary. Therefore, increasing the flu vaccination coverage should be achieved, not only with free -of- charge vaccines and financial incentives, but also with other possible options such as raising the awareness among people and implementing an effective, follow up system.

Published
2020
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166. Neutrophil Inflammatory Response Is Downregulated by Uptake of Superparamagnetic Iron Oxide Nanoparticle Therapeutics

Author

Scott I. Simon, Min-Ho Kim, Gustavo Garcia, and Vasilios A. Morikis

Subjects
lcsh:Immunologic diseases. Allergy, 0301 basic medicine, iron oxide, Endothelium, Neutrophils, immunosupression, Immunology, Inflammation, 02 engineering and technology, Pharmacology, neutrophil degranulation, Cell Degranulation, Neutrophil Activation, Receptors, Interleukin-8A, 03 medical and health sciences, Downregulation and upregulation, medicine, Humans, Immunology and Allergy, Calcium Signaling, L-Selectin, Receptor, innate immunity, Cells, Cultured, Original Research, Innate immune system, Anemia, Iron-Deficiency, Chemistry, nanoparticle, Interleukin-8, Degranulation, Chemotaxis, neutrophil recruitment, 021001 nanoscience & nanotechnology, Ferrosoferric Oxide, 030104 developmental biology, medicine.anatomical_structure, CD18 Antigens, mechanosignaling, Neutrophil degranulation, Kidney Failure, Chronic, Magnetic Iron Oxide Nanoparticles, medicine.symptom, lcsh:RC581-607, 0210 nano-technology
Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular sites of inflammation via a sequential process that is characterized by adhesive capture, rolling, and shear resistant arrest. A primary chemotactic agonist presented on the glycocalyx of inflamed endothelium is IL-8, which upon binding to its cognate membrane receptor (CXCR1/2) activates a suite of responses in neutrophils. An early response is degranulation with accompanying upregulation of β2-integrin (CD11/CD18) and shedding of L-selectin (CD62L) receptors, which exert differential effects on the efficiency of endothelial recruitment. Feraheme is an FDA approved SPION treatment for IDA, but its effect on the innate immune response of neutrophils during inflammation has not been reported. Here, we studied the immunomodulatory effects of Feraheme on neutrophils freshly isolated from healthy human subjects and stimulated in suspension or on inflammatory mimetic substrates with IL-8. Cells treated with Feraheme exhibited reduced sensitivity to stimulation with IL-8, indicated by reduced upregulation of membrane CD11b/CD18 receptors, high affinity (HA) CD18, and shedding of CD62L. Feraheme also inhibited N-formyl-Met-Leu-Phe (fMLP) induced reactive oxygen species production. Neutrophil rolling, arrest, and migration was assessed in vascular mimetic microfluidic channels coated with E-selectin and ICAM-1 to simulate inflamed endothelium. Neutrophils exposed to Feraheme rolled faster on E-selectin and arrested less frequently on ICAM-1, in a manner dependent upon SPION concentration. Subsequent neutrophil shape change, and migration were also significantly inhibited in the presence of Feraheme. Lastly, Feraheme accelerated clearance of cytosolic calcium flux following IL-8 stimulation. We conclude that uptake of Feraheme by neutrophils inhibits chemotactic activation and downregulates normal rolling to arrest under shear flow. The mechanism involves increased calcium clearance following chemotactic activation, which may diminish the efficiency of recruitment from the circulation at vascular sites of inflammation.

Published
2020
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167. Evading the host response: Staphylococcus 'hiding' in cortical bone canalicular system causes increased bacterial burden

Author

Jeff F. Miller, Gideon Blumstein, Kellyn R. Hori, Christopher D. Hamad, Howard Y. Park, Amanda H. Loftin, Daniel Johansen, Scott I. Simon, Chad R Ishmael, Zachary D. C. Burke, Scott D. Nelson, Ryan Smith, Nicholas M. Bernthal, Vishal Hegde, Rachel M. Borthwell, Samuel J. Clarkson, Marina M. Sprague, William L. Sheppard, and Stephen D. Zoller

Subjects
0301 basic medicine, Pathology, Physiology, Endocrinology, Diabetes and Metabolism, Pathogenesis, Bone canaliculus, lcsh:Physiology, 0302 clinical medicine, Anti-Infective Agents, Bone cancer, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Biomass, Aetiology, lcsh:QH301-705.5, 030222 orthopedics, lcsh:QP1-981, Chlorhexidine, Salicylates, Drug Combinations, medicine.anatomical_structure, Infectious Diseases, Local, Infection, Cancellous bone, medicine.medical_specialty, Histology, Clinical Sciences, Dental Plaque, Article, Fluorescence, 03 medical and health sciences, Immune system, Clinical Research, medicine, Humans, Dental/Oral and Craniofacial Disease, Bone, Saliva, Ecosystem, Bacteriological Techniques, Bacteria, business.industry, Terpenes, Osteomyelitis, Prevention, Haversian canal, Implant Infection, medicine.disease, Culture Media, 030104 developmental biology, Emerging Infectious Diseases, lcsh:Biology (General), Musculoskeletal, Biofilms, Cortical bone, Implant, business
Abstract

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone loss. Debate persists as to the optimal void filler for this “limb salvage” surgery, whether metal or allograft bone. Clinicians focus on optimizing important functional gains for patients, and the risk of devastating implant infection has been thought to be similar regardless of implant material. Recent insights into infection pathophysiology are challenging this equipoise, however, with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus (the most common infecting agent) into the host lacunar–canaliculi network, and also clinical data revealing a higher rate of infection of allograft over metal. The current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and metal. Real-time Staphylococci infection characteristics were quantified in cortical bone vs metal, and both microarchitecture of host implant and presence of host immune response were assessed. An orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous bone. The establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone infection. These study results reveal a mechanism by which Staphylococci evasion of host immunity is possible, contributing to elevated risks of infection in cortical bone. The presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment.

Published
2020

169. One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients

Author

Maria Parke, Te Hsin Lung, Gregg W. Stone, James W. Choi, Brent T. McLaurin, Elvin Kedhi, Alexandre Abizaid, David E. Kandzari, Ronald P. Caputo, Roxana Mehran, Stephan Windecker, Azfar Zaman, Azeem Latib, Mihir Kanitkar, Ajay J. Kirtane, Stephen G. Worthley, Matthew J. Price, Tamim Nazif, Douglas Spriggs, Thaddeus R. Tolleson, Timothy Smith, Daniel I. Simon, Srinivasa Potluri, and Lilian C. Lee

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Hemorrhage, Coronary Artery Disease, Prosthesis Design, Risk Assessment, Drug Administration Schedule, Percutaneous Coronary Intervention, Japan, Risk Factors, Internal medicine, medicine, Humans, Zotarolimus, Limited evidence, Prospective Studies, goals, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Sirolimus, business.industry, Dual Anti-Platelet Therapy, Percutaneous coronary intervention, drug-eluting stents, Cardiovascular Agents, Original Articles, Middle Aged, United States, Coronary Interventions, Treatment Outcome, stents, Cardiology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

Supplemental Digital Content is available in the text., Background: Despite treatment guidance endorsing shortened dual antiplatelet therapy (DAPT) duration in high bleeding risk (HBR) patients after drug-eluting stents, limited evidence exists to support these recommendations. The present study was designed to examine the safety and effectiveness of 1-month DAPT duration following percutaneous coronary intervention with zotarolimus-eluting stents in HBR patients. Methods: Onyx ONE Clear was a prospective, multicenter, nonrandomized study evaluating the safety and effectiveness of 1-month DAPT followed by single antiplatelet therapy in HBR patients undergoing percutaneous coronary intervention with Resolute Onyx drug-eluting stents. The primary analysis of cardiac death or myocardial infarction between 1 month and 1 year was performed in the prespecified one-month clear population of patients pooled from the Onyx ONE US/Japan study and Onyx ONE randomized controlled trial. One-month clear was defined as DAPT adherence and without major adverse events during the first month following percutaneous coronary intervention. Results: Among patients enrolled in Onyx ONE US/Japan (n=752) and Onyx ONE randomized controlled trial (n=1018), 1506 patients fulfilled one-month clear criteria. Mean HBR characteristics per patient was 1.6 with 44.7% having multiple risks. By 2 months and 1 year, respectively, 96.9% and 89.3% of patients were taking single antiplatelet therapy. Between 1 month and 1 year, the rate of the primary end point was 7.0%. The 1-sided upper 97.5% CI was 8.4%, less than the performance goal of 9.7% (P

Published
2020

170. Oleanolic acid protection against experimental autoimmune myocarditis modulates the microbiota and the intestinal barrier integrity

Author

Victoria Cachofeiro, M. L. Nieto Callejo, Isabel Gallardo, M. I. Cabero, Beatriz Gutiérrez, I Simon, M Hernandez, Juan Carlos Muñoz, J.A. San Roman, Abelardo Margolles, Yolanda Alvarez, H Calvo, and Lorena Ruiz

Subjects
Autoimmune myocarditis, chemistry.chemical_compound, chemistry, business.industry, Immunology, Medicine, Barrier integrity, Cardiology and Cardiovascular Medicine, business, Oleanolic acid
Abstract

Background Autoimmune myocarditis is a cause of dilated cardiomyopathy and heart failure. Recent studies have indicated that leaky gut may allow environmental factors to enter the body and trigger the initiation/development of autoimmune disease. Moreover, there is a growing literature supporting that, beside myocardial fibrosis, a leaky intestinal barrier and gut dysbiosis are pathogenic factors linked to heart failure. The natural triterpene oleanolic acid (OA) has been shown to beneficially influence the severity of the experimental autoimmune myocarditis (EAM), a preclinical model of human myocarditis, via anti-oxidant and immunomodulatory mechanisms. Herein, we investigate gastrointestinal (GI) disturbances and the gut microbiota composition associated with EAM as potential therapeutic target of OA. Methods and results BALB/c mice were α-myosin-inmunized to induce EAM and treated with OA (25 mg/kg/day, i.p). On day 21, heart fibrosis and parameters related to gut damage such as oxidative stress (O2- ions, lipid peroxidation), gut permeability (D-lactate; I-FABP), inflammation and mucins were determined in serum and/or colon. Fecal microbial profiles were identified by 16S rRNA gene sequencing analysis. Firstly, histological analysis of hearts showed presence of fibrosis (Sirius Red stain) in EAM mice, whereas these effects were not detectable in myocardium from healthy or OA-treated EAM mice. In addition, OA preserved the mucin-containing goblet cells along the colon (Alcian Blue/PAS stain). Consistently, serum levels of the epithelial gut damage markers, including D-lactate and iFABP were significantly reduced in OA treated-EAM mice. The beneficial OA effects also included a decrease in the pro-inflammatory mediators sPLA2-IIA and IL-1β and a protection from the oxidative stress response (DHE stain and TBARS) in serum and colonic tissue of EAM-mice. Furthermore, gut microbiota composition showed a lower bacterial diversity and different relative abundance of certain bacterial taxa in EAM-mice compared to control mice. The families of Muribaculaceae, Lachnospiraceae, and Ruminococcaceae were significantly affected in EAM mice, and only Muribaculaceae recovered levels similar to the healthy-control group, after treatment with OA. Conclusion Our data show that in addition to the heart, the intestinal barrier and gut microbiota are altered in myocarditis, and that OA treatment could ameliorate this profile. Our data contribute to the idea that gut dysbiosis and GI dysfunction influences myocarditis pathogenesis, and provides new findings regarding the beneficial activity of OA in EAM, suggesting that it may be an interesting candidate to be explored for the treatment of human patients. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): MINECO, ISCIII, CIBERCV-ISCIII

Published
2020
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171. Onyx ONE: outcomes in patients with acute coronary syndrome

Author

Azfar Zaman, M Parke, Azeem Latib, Stephen G. Worthley, Andrea Abizaid, Daniel I. Simon, S Windecker, T Lung, Elvin Kedhi, Matthew J. Price, Roxana Mehran, Aiay J. Kirtane, David E. Kandzari, and Gregg W. Stone

Subjects
Acute coronary syndrome, medicine.medical_specialty, business.industry, Unstable angina, medicine.medical_treatment, medicine.disease, Revascularization, Zollinger-Ellison syndrome, Internal medicine, Cardiology, Medicine, In patient, Zotarolimus, Stent thrombosis, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background/Introduction The Onyx ONE Global Study (Onyx ONE), a randomized, single-blind, international trial, demonstrated non-inferiority of a zotarolimus-eluting stent (ZES) to a polymer-free drug-coated stent (DCS) in high-bleeding risk patients treated with 1-month dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT). More than half of the Onyx ONE patients presented with an acute coronary syndrome (ACS). The safety and effectiveness of ZES and DCS in ACS patients treated with SAPT after 30 days remains unknown. Purpose To evaluate the safety and effectiveness outcomes for ZES and DCS in Onyx ONE patients presenting with ACS. Methods The primary outcome of the trial was a composite of cardiac death, myocardial infarction, or stent thrombosis at 1 year. To align with the time that DAPT is interrupted, we also evaluated the primary endpoint between the 2 stent groups in a landmark analysis between 30 days and 1 year. All analyses were performed in ACS patients (includes unstable angina, non ST-elevation myocardial infarction and ST-elevation myocardial infarction). Results Among the 1996 patients randomized in Onyx ONE, 982/1902 (51.6%) presented with ACS, of which 511/982 (52.0%) and 471/982 (48.0%) were treated with ZES and DCS respectively. In a pre-defined subgroup analysis in ACS patients, the event rates between the two stent groups regarding the primary outcome at one year were similar (18.5% ZES; 20.8% DCS; HR: 0.91; 95% CI [0.68, 1.22]; p=0.523). In the landmark analysis beyond day 30, the primary outcome rate tended to be lower among those treated with the ZES (8.4%) compared with the DCS (12.1%) [HR: 0.66 (95% CI: 0.43, 1.01), p=0.055] (Figure). This was primarily driven by lower rates of myocardial infarction with ZES (6.5% ZES; 10.2% DCS; [HR: 0.58 (95% CI: 0.36, 0.93); p=0.025], while other components were similar: cardiac death, 2.6% ZES vs. 2.8% DCS [HR: 1.00 (95% CI: 0.44, 2.27); p>0.99) and stent thrombosis, 1.4% ZES vs. 1.4% DCS [HR: 0.93 (95% CI: 0.27, 3.21); p=0.91]. Conclusions In Onyx ONE, high-bleeding risk patients presenting with ACS had similar safety and efficacy at 1 year in both the ZES and DCS stent groups. However, a trend was present for greater safety with the ZES with SAPT treatment beyond 30 days driven by lower myocardial infarction rates in that time period thus warranting additional confirmatory studies. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Medtronic sponsored the Onyx ONE Global Study

Published
2020
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172. Iron status, anemia and functional capacity in adults with congenital heart disease: a single center analysis

Author

Maximilian Brockmeyer, Tobias Zeus, C Parco, Athanasios Karathanos, I Simon, Volker Schulze, Katharina Hellhammer, T Krieger, Georg Wolff, Malte Kelm, and Yingfeng Lin

Subjects
medicine.medical_specialty, Ejection fraction, Heart disease, biology, Anemia, business.industry, Iron deficiency, medicine.disease, Single Center, Ferritin, Internal medicine, Heart failure, medicine, Cardiology, biology.protein, Iron status, Cardiology and Cardiovascular Medicine, business
Abstract

Background Iron is essential to the mitochondrial energy production in cardiomyocytes and its depletion is negatively associated with symptoms, functional capacity, quality of life and outcomes in patients with heart failure – independent of anemia. The relevance of iron deficiency in adults with congenital heart disease however has not been evaluated to date, and we thus aimed to evaluate it in an all-comer cohort of patients with congenital heart disease in correlation with symptoms and functional capacity. Methods and results 527 patient cases from one referral center over 2 years were evaluated concerning their iron status, anemia, functional capacity and ejection fraction of their systemic ventricle. 264 were female, 94 had a shunt lesion, 96 had left-sided obstructive lesions, 181 right-sided lesions, while 108 were considered to have complex lesions and 28 were cyanotic. The median age was 34 years, the mean BMI was 25.2±5 kg/m2, 429 patients had a normal ejection fraction and 34 moderately and severely depressed. 35 patients were classified as NYHA III, and 56 as NYHA II, while their functional capacity was evaluated via cardiopulmonary testing with a mean VO2max/kg of 22.6±6.5 and mean 69±17% of the expected. The mean serum iron concentration was 99.4±42.3 mcg/dL, their mean transferrin saturation was 27.36±13%, the mean ferritin concentration was 130.8±185 ng/mL, the mean soluble transfer factor was 1.3±0.66 mg/l and their mean Hemoglobin 14.8±2 mg/dL, while the mean MCV was 88±5.3 and the mean MCHC 33.7±1.4. 40 patients were anemic according to the WHO definition for anemia, in 28 of those patients that was already known. Iron deficiency according to stratified according to ferritin was present in 53 patients. However, when stratified according to the heart failure guidelines definition for iron deficiency 299 patients were found affected. Using the soluble transferrin receptor (sTfR) and sTfR-ferritin index iron deficiency was suspected in 10 additional individuals. Iron deficiency was associated with the ejection fraction (p=0.0001) - patients with moderately or severely depressed systemic ventricular function more often were diagnosed with iron deficiency (p=0.007)-, while it did not correlate with functional NYHA classification (p=0.622) or functional capacity (p=0.1 and 0.057). Iron deficiency was also not found significantly different amongst congenital defects but did correlate with all laboratory iron studies. Conclusions In this ambulatory population of adults with congenital heart disease we found an association of ejection fraction with iron deficiency, however no association of iron deficiency with functional capacity. The question arising is if a new definition of iron deficiency anemia in congenital heart disease similar to heart failure would be of clinical value. Funding Acknowledgement Type of funding source: None

Published
2020
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173. Prenatal description of retinal coloboma

Author

Mikael Tassin, C. Egloff, Olivier Picone, J.P. Bault, I. Simon, Laurent Mandelbrot, A. Barjol, A. Collin, Jeanne Sibiude, Université de Paris (UP), and Fondation Ophtalmologique Adolphe de Rothschild [Paris]

Subjects
medicine.medical_specialty, Retinal coloboma, [SDV]Life Sciences [q-bio], Prenatal diagnosis, Microphthalmia, Associated sign, 03 medical and health sciences, chemistry.chemical_compound, CHARGE syndrome, 0302 clinical medicine, Ophthalmology, Medicine, Coloboma, 030219 obstetrics & reproductive medicine, business.industry, Ultrasound, Obstetrics and Gynecology, Retinal, medicine.disease, eye diseases, 3. Good health, Reproductive Medicine, chemistry, 030220 oncology & carcinogenesis, sense organs, business
Abstract

Retinal coloboma is a rare condition which is difficult to diagnose in foetuses. It can cause blindness. It can be isolated or associated with other malformations in various syndromes. Our objective is to describe the different prenatal ultrasound findings and management of coloboma. We describe a case of prenatal ultrasound diagnosis of retinal coloboma at 27.5 weeks of gestation. Our case adds to the 8 previously reported in the prenatal ultrasound literature, which together illustrate that microphthalmia is the main associated sign, present in 66.6% (6/9) of cases followed by retro-orbital cysts (44.4%) (4/9). These two ultrasound findings should alert us to a close examination of the eye to look for a posterior retinal cleft, the main direct sign of a chorioretinal coloboma.

Published
2020
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174. Mass spectrometry-based serum proteomic signature as a potential biomarker for survival in patients with non-small cell lung cancer receiving immunotherapy

Author

Taeyeong Ko, Pedro Viveiros, Manali Bhave, Jonathan F. Anker, Anderson Cho, Young Kwang Chae, Won Bin Kim, Michael Oh, Nicholas I. Simon, Junho Song, Kyunghoon Rhee, Lee Chun Park, Andrew M. Davis, and Sangmin Chang

Subjects
Oncology, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, non-small cell lung cancer (NSCLC), Retrospective cohort study, Pembrolizumab, medicine.disease, Internal medicine, medicine, Biomarker (medicine), Original Article, Veristrat, Nivolumab, Lung cancer, business
Abstract

Background VeriStrat test is a serum assay which uses a mass spectrometry (MS)-based proteomic signature derived from machine learning. It is currently used as a prognostic marker for patients with non-small cell lung cancer (NSCLC) receiving chemotherapy. However, little is known about its role for NSCLC patients receiving immune checkpoint inhibitors (ICIs). Methods This is a retrospective study that includes 47 patients with advanced stage NSCLC without an activating EGFR mutation, who underwent the VeriStrat test from 2016 to 2018. Spectra from blood samples were evaluated to assign patients into the VeriStrat 'Good' (VS-G) or VeriStrat 'Poor' (VS-P) risk group. The clinical outcomes of 32 patients who received programmed cell death 1 (PD-1) inhibitors nivolumab or pembrolizumab were analyzed by VeriStrat status. Results The VS-G group demonstrated significantly higher progression-free survival (PFS) and overall survival (OS) compared to the VS-P group among overall NSCLC patients regardless of treatment (median PFS of 7.1 vs. 4.2 months, P=0.013, and median OS, not reached vs. 17.2 months, P=0.012). Among NSCLC patients treated with ICIs, VS-G classification was associated with significantly increased PFS in comparison to VS-P classification (median PFS of 6.2 vs. 3.0 months, P=0.012), while the differences in OS trended towards significance (median OS, not reached vs. 16.5 months P=0.076). Multivariate analysis showed that the VeriStrat status was significantly correlated with PFS and OS in NSCLC patients treated with ICIs (P=0.017, P=0.034, respectively). Conclusions MS-based serum proteomic signature has potential as a biomarker for survival outcome in NSCLC patients receiving immunotherapy.

Published
2020

175. Impact of COVID ‐19 pandemic on ST‐elevation myocardial infarction in a non‐COVID ‐19 epicenter

Author

Nour Tashtish, Melanie Parikh, Mehdi H. Shishehbor, Cynthia M Lowry, Diane Gorbey, Tarek A Hammad, Farshad Forouzandeh, Marco A. Costa, William M Wolf, Daniel I. Simon, and Steven J Filby

Subjects
medicine.medical_specialty, Ejection fraction, biology, business.industry, General Medicine, medicine.disease, Troponin, Intensive care unit, law.invention, Blood pressure, law, Radiology Nuclear Medicine and imaging, Statistical significance, Internal medicine, Heart rate, Cardiology, Door-to-balloon, biology.protein, Medicine, Radiology, Nuclear Medicine and imaging, Myocardial infarction, business, Cardiology and Cardiovascular Medicine
Abstract

Objectives We sought to study the impact of COVID-19 pandemic on the presentation delay, severity, patterns of care, and reasons for delay among patients with ST-elevation myocardial infarction (STEMI) in a non-hot-spot region. Background COVID-19 pandemic has significantly reduced the activations for STEMI in epicenters like Spain. Methods From January 1, 2020, to April 15, 2020, 143 STEMIs were identified across our integrated 18-hospital system. Pre- and post-COVID-19 cohorts were based on March 23rd, 2020, whenstay-at-home orders were initiated in Ohio. We used presenting heart rate, blood pressure, troponin, new Q-wave, and left ventricle ejection fraction (LVEF) to assess severity. Duration of intensive care unit stay, total length of stay, door-to-balloon (D2B) time, and radial versus femoral access were used to assess patterns of care. Results Post-COVID-19 presentation was associated with a lower admission LVEF (45 vs. 50%, p = .015), new Q-wave, and higher initial troponin; however, these did not reach statistical significance. Among post-COVID-19 patients, those with >12-hr delay in presentation 31(%) had a longer average D2B time (88 vs. 53 min, p = .033) and higher peak troponin (58 vs. 8.5 ng/ml, p = .03). Of these, 27% avoided the hospital due to fear of COVID-19, 18% believed symptoms were COVID-19 related, and 9% did not want to burden the hospital during the pandemic. Conclusions COVID-19 has remarkably affected STEMI presentation and care. Patients' fear and confusion about symptoms are integral parts of this emerging public health crisis.

Published
2020
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176. Transcatheter Valve Implantation for Failed Surgical Aortic and Mitral Bioprostheses: A Single-Center Experience

Author

Jerry, Lipinski, Sandeep M, Patel, Toral R, Patel, Daniel, Kobe, Petar, Saric, Muhammad, Panhwar, Fahd, Nadeem, Jun, Li, Joshua R, Clevenger, Yasuhiro, Ichibori, Anas, Fares, Katherine, Lang, Hiram G, Bezerra, Basar, Sareyyupoglu, Benjamin, Medalion, Salil, Deo, Yakov, Elgudin, Alan, Markowitz, Daniel I, Simon, Marco A, Costa, Ankur, Kalra, and Guilherme F, Attizzani

Subjects
Aged, 80 and over, Bioprosthesis, Heart Valve Prosthesis Implantation, Transcatheter Aortic Valve Replacement, Treatment Outcome, Aortic Valve, Heart Valve Prosthesis, Humans, Mitral Valve Insufficiency, Aged, Prosthesis Failure
Abstract

We share our center's experience with the use of transcatheter valvular therapies in the setting of failed bioprostheses.As medicine continues to advance, the lifespan of individuals continues to increase, and current surgical valvular therapies begin to degrade prior to a person's end of life. It is important to evaluate the efficacy and durability of transcatheter valves within failed surgical bioprostheses.Baseline characteristics, periprocedural complications, and long-term outcomes were collected and assessed in patients who received transcatheter valves for failing surgical aortic valve bioprostheses and mitral valve and ring bioprostheses from March 2011 to July 2018.From our cohort of 1048 patients, we identified 45 individuals (4.3%) who underwent transcatheter replacement of a failed bioprosthetic valve or ring. Mean age at presentation was 80.8 ± 10.7 years and 75.5 ± 9.3 years, mean STS score was 9.3 ± 5.1 and 13.3 ± 8.7, and mean time to failure was 12.0 ± 5.2 years and 7.3 ± 4.5 years for aortic and mitral positions, respectively. At 1 year, time to event analysis suggested a 16.4% mortality rate for aortic replacement and 12.8% mortality rate for mitral replacement.We demonstrate outcomes from one of the largest single-center United States based cohorts of transcatheter replacements of failed surgical bioprostheses. Our center has demonstrated that it is feasible to pursue the replacement of failed surgical bioprostheses in the aortic and mitral positions with transcatheter valves given appropriate patient selection.

Published
2020

177. How Have ACA Insurance Expansions Affected Health Outcomes? Findings From The Literature

Author

Aparna, Soni, Laura R, Wherry, and Kosali I, Simon

Subjects
Adult, Insurance, Health, Medicaid, Patient Protection and Affordable Care Act, Outcome Assessment, Health Care, Infant, Newborn, Humans, Health Services Accessibility, Insurance Coverage, United States
Abstract

A growing body of literature examining the effects of the Affordable Care Act (ACA) on nonelderly adults provides promising evidence of improvements in health outcomes through insurance expansions. Our review of forty-three studies that employed a quasi-experimental research design found encouraging evidence of improvements in health status, chronic disease, maternal and neonatal health, and mortality, with some findings corroborated by multiple studies. Some studies further suggested that the beneficial effects have grown over time and thus may continue to grow if the ACA insurance expansions remain in force. However, not all studies reported a significant positive relationship between ACA provisions that expanded insurance coverage and health status. We highlight the challenges facing researchers, including the importance of nonmedical factors in determining individual health and the use of outcome data predominantly drawn from self-reports. In closing, we identify opportunities to enhance researchers' understanding of the relationship between the ACA insurance expansions and health outcomes using new data sources, including electronic health records.

Published
2020

178. A Coordinated Microstructural and Isotopic Study of a Wark-Lovering Rim on a Vigarano CAI

Author

Justin I. Simon, Ming-Chang Liu, Lindsay P. Keller, J. Han, Scott Messenger, A. T. Hertwig, and A. W. Needham

Subjects
Materials science, Olivine, Diopside, 010504 meteorology & atmospheric sciences, Geochemistry, Melilite, Forsterite, engineering.material, 010502 geochemistry & geophysics, Anorthite, 01 natural sciences, Article, Grossite, Geochemistry and Petrology, visual_art, engineering, visual_art.visual_art_medium, Hibonite, Gehlenite, 0105 earth and related environmental sciences
Abstract

We carried out a coordinated mineralogical and isotopic study of a Wark-Lovering (WL) rim on a Ca,Al-rich inclusion (CAI) from the reduced CV3 chondrite Vigarano. The outermost edge of the CAI mantle is mineralogically and texturally distinct compared to the underlying mantle that is composed of coarse, zoned melilite (Åk(~10–60)) grains. The mantle edge contains fine-grained gehlenite with hibonite and rare grossite that likely formed by rapid crystallization from a melt enriched in Ca and Al. These gehlenite and hibonite layers are surrounded by successive layers of spinel, zoned melilite (Åk(~0–10)), zoned diopside that grades outwards from Al,Ti-rich to Al,Ti-poor, and forsteritic olivine intergrown with diopside. These layered textures are indicative of sequential condensation of spinel, melilite, diopside, and forsterite onto hibonite. Anorthite occurs as a discontinuous layer that corrodes adjacent melilite and Al-diopside, and appears to have replaced them, probably even later than the forsterite layer formation. Based on these observations, we conclude that the WL rim formation was initiated by flash melting and extensive evaporation of the original inclusion edge, followed by subsequent gas-solid reactions under highly dynamic conditions. All the WL rim minerals are (16)O-rich (Δ(17)O = ~−23‰), indicating their formation in an (16)O-rich nebular reservoir. Our Al-Mg measurements of hibonite, spinel, and diopside from the WL rim, as well as spinel and Al,Ti-diopside in the core, define a single, well-correlated isochron with an inferred initial (26)Al/(27)Al ratio of (4.94 ± 0.12) × 10(−5). This indicates that the WL rim formed shortly after the host CAI. In contrast, the lack of (26)Mg excesses in the WL rim anorthite suggest its later formation or later isotopic disturbance in the solar nebula, after (26)Al had decayed.

Published
2020

179. Tensile force transmitted through LFA-1 bonds mechanoregulate neutrophil inflammatory response

Author

Scott I. Simon, Vasilios A. Morikis, and Eman Masadeh

Subjects
0301 basic medicine, ORAI1 Protein, Neutrophils, Immunology, chemistry.chemical_element, Calcium, Biology, Receptors for Activated C Kinase, Mechanotransduction, Cellular, 03 medical and health sciences, 0302 clinical medicine, Tensile Strength, Calcium flux, Immunology and Allergy, Humans, Mechanotransduction, Inflammation, ORAI1, Endoplasmic reticulum, Calcium channel, Membrane Proteins, STIM1, Cell Biology, Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1, Neoplasm Proteins, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Biophysics, Selectin
Abstract

Recruitment of leukocytes to sites of acute inflammation is guided by spatial and temporal cues that ensure appropriate cell numbers infiltrate the tissue at precise locations to protect it from infection and initiate repair. On inflamed endothelium, neutrophil rolling via selectins elicits cytosolic calcium release from endoplasmic reticulum (ER)-stores that are synergistic with chemokine signaling to activate formation of high affinity (HA) LFA-1 bonds to ICAM-1, which is necessary to anchor cells against the drag force of blood flow. Bond tension on LFA-1 within the area of adhesive contact with endothelium elicits calcium entry through calcium release-activated calcium channel protein 1 (Orai-1) membrane channels that in turn activate neutrophil shape change and migration. We hypothesized that mechanotransduction via LFA-1 is mediated by assembly of a cytosolic molecular complex consisting of Kindlin-3, receptor for activated C kinase 1 (RACK1), and Orai1. Initiation of Ca2+ flux at sites of adhesive contact required a threshold level of shear stress and increased with the magnitude of bond tension transduced across as few as 200 HA LFA-1. A sequential mechanism triggered by force acting on LFA-1/Kindlin-3 precipitated dissociation of RACK1, which formed a concentration gradient above LFA-1 bond clusters. This directed translocation of ER proximal to Orai1, where binding of inositol 1,4,5-triphosphate receptor type 1 and activation via stromal interaction molecule 1 elicited Ca flux and subsequent neutrophil shape change and motility. We conclude that neutrophils sense adhesive traction on LFA-1 bonds on a submicron scale to direct calcium influx, thereby ensuring sufficient shear stress of blood flow is present to trigger cell arrest and initiate transmigration at precise regions of vascular inflammation.

Published
2020

181. Volatiles in lunar felsite clasts: Impact-related delivery of hydrous material to an ancient dry lunar crust

Author

Justin I. Simon, Daniel K. Ross, R. Christoffersen, Jianhua Wang, M. D. Mouser, Zia Ur Rahman, C. M. O'd. Alexander, and Ryan D. Mills

Subjects
Felsite, Felsic, 010504 meteorology & atmospheric sciences, Geochemistry, engineering.material, 010502 geochemistry & geophysics, Feldspar, 01 natural sciences, Magmatic water, Geochemistry and Petrology, visual_art, Breccia, Magma, engineering, visual_art.visual_art_medium, Plagioclase, Mafic, Geology, 0105 earth and related environmental sciences
Abstract

In this detailed geochemical, petrological, and microstructural study of felsite clast materials contained in Apollo breccia samples 12013, 14321, and 15405, little evidence was found for relatively enriched reservoirs of endogenic lunar volatiles. NanoSIMS measurements have revealed very low volatile abundances ( ≤ 2–18 ppm hydrogen) in nominally anhydrous minerals (NAMS) plagioclase, potassic alkali feldspar, and SiO2 that make up a majority of these felsic lithologies. Yet these mineral assemblages and clast geochemistries on Earth would normally yield relatively high volatiles contents in their NAMS (∼20 to ≥ 80 ppm hydrogen). This difference is particularly notable in felsite 14321,1062 that exhibits extremely low volatile abundances ( ≤ 2 ppm hydrogen) and a relatively low amount of microstructural evidence for shock metamorphism given that it is a clast of the most evolved (∼74 wt.% SiO2) rock-type returned from the Moon. If taken at face value, ‘wet’ felsic magmas (∼1.2–1.7 wt.% water) are implied by the relatively high hydrogen contents of feldspar in felsite clasts in Apollo samples 12013 and 15405, but these results are likely misleading. These felsic clasts have microstructural features indicative of significantly higher shock stress than 14321,1062. These crustal lithologies likely obtained no more water from the lunar interior than the magma body producing 14321,1062. Rather, we suggest hydrogen was enriched in samples 12013 and 15405 by impact induced exchange, and/or partial assimilation of volatiles added to the surface of the Moon by a hydrated impactor (asteroid or comet) or the solar wind. Thus, the best estimate for magmatic water contents of felsic lunar magmas comes from 14321,1062 that leads to a calculated magmatic water content of ≤ 0.2 wt.%. This dry felsic magma has a slightly greater, but comparable water content to the ancient mafic magmas implied by the other lithologies that we have studied. Based on this and expanding evidence for a significantly dry ancient or early degassed Moon it is likely that some recent estimates (100's ppm) of the water abundances in the lunar parental magma ocean have been overestimated.

Published
2020
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183. Polymer-based or polymer-free stents in patients at high bleeding risk

Author

Seung Ho Hur, Kamaraj Selvaraj, Elvin Kedhi, Onyx One Investigators, Azfar Zaman, Matthew J. Price, Martin Hudec, Sanjeevan Pasupati, Steven O. Marx, Stephen G. Worthley, Sandeep Brar, Roxana Mehran, Raul Moreno, Minglei Liu, A Kahar Bin Abdul Ghapar, Azeem Latib, Eduardo Pinar, Darren Mylotte, Gregg W. Stone, Lisa Bousquette, Charles Tie, Hyo-Soo Kim, Adel Aminian, Ivana Jankovic, Daniel I. Simon, Petra Poliacikova, Adrian Wlodarczak, Stephan Windecker, Alexandre S Abizaid, Franco Fabbiocchi, David E. Kandzari, Ajay J. Kirtane, and Ivo Petrov

Subjects
Polymers, medicine.medical_treatment, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, law.invention, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Ús terapèutic, Single-Blind Method, 030212 general & internal medicine, Side effects, Drug-Eluting Stents, General Medicine, Polímers, surgical procedures, operative, Drug Therapy, Combination, Immunosuppressive Agents, medicine.drug, medicine.medical_specialty, Heart Diseases, Polymer free, Hemorrhage, Prosthesis Design, 03 medical and health sciences, Coronary arteries, Percutaneous Coronary Intervention, medicine, Humans, In patient, cardiovascular diseases, Efectes secundaris, Sirolimus, Immunosupressió, business.industry, Coronary Thrombosis, Therapeutic use, Percutaneous coronary intervention, equipment and supplies, medicine.disease, Surgery, Multicenter study, Conventional PCI, business, Artèries coronàries, Platelet Aggregation Inhibitors, Immunosuppression
Abstract

Background: polymer-free drug-coated stents provide superior clinical outcomes to bare-metal stents in patients at high bleeding risk who undergo percutaneous coronary intervention (PCI) and are treated with 1 month of dual antiplatelet therapy. Data on the use of polymer-based drug-eluting stents, as compared with polymer-free drug-coated stents, in such patients are limited. Methods: in an international, randomized, single-blind trial, we compared polymer-based zotarolimus-eluting stents with polymer-free umirolimus-coated stents in patients at high bleeding risk. After PCI, patients were treated with 1 month of dual antiplatelet therapy, followed by single antiplatelet therapy. The primary outcome was a safety composite of death from cardiac causes, myocardial infarction, or stent thrombosis at 1 year. The principal secondary outcome was target-lesion failure, an effectiveness composite of death from cardiac causes, target-vessel myocardial infarction, or clinically indicated target-lesion revascularization. Both outcomes were powered for noninferiority. Results: a total of 1996 patients at high bleeding risk were randomly assigned in a 1:1 ratio to receive zotarolimus-eluting stents (1003 patients) or polymer-free drug-coated stents (993 patients). At 1 year, the primary outcome was observed in 169 of 988 patients (17.1%) in the zotarolimus-eluting stent group and in 164 of 969 (16.9%) in the polymer-free drug-coated stent group (risk difference, 0.2 percentage points; upper boundary of the one-sided 97.5% confidence interval [CI], 3.5; noninferiority margin, 4.1; P = 0.01 for noninferiority). The principal secondary outcome was observed in 174 patients (17.6%) in the zotarolimus-eluting stent group and in 169 (17.4%) in the polymer-free drug-coated stent group (risk difference, 0.2 percentage points; upper boundary of the one-sided 97.5% CI, 3.5; noninferiority margin, 4.4; P = 0.007 for noninferiority). Conclusions: among patients at high bleeding risk who received 1 month of dual antiplatelet therapy after PCI, use of polymer-based zotarolimus-eluting stents was noninferior to use of polymer-free drug-coated stents with regard to safety and effectiveness composite outcomes. (Funded by Medtronic; ONYX ONE ClinicalTrials.gov number, NCT03344653.).

Published
2020

184. sj-pdf-1-mcr-10.1177_1077558720974144 – Supplemental material for The Affordable Care Act Young Adult Mandate and Suicidal Behavior

Author

O’Reilly, Lauren Marie, Froberg, Blake A., Gian, Cong Thanh, D’Onofrio, Brian Matthew, and Kosali I. Simon

Subjects
111799 Public Health and Health Services not elsewhere classified, 160807 Sociological Methodology and Research Methods, FOS: Health sciences, FOS: Sociology
Abstract

Supplemental material, sj-pdf-1-mcr-10.1177_1077558720974144 for The Affordable Care Act Young Adult Mandate and Suicidal Behavior by Lauren Marie O’Reilly, Blake A. Froberg, Cong Thanh Gian, Brian Matthew D’Onofrio and Kosali I. Simon in Medical Care Research and Review

Published
2020
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185. The association of FDG PET/CT and NaF PET/CT with survival outcomes in patients (pts) with metastatic genitourinary malignancies (mGU) treated with cabozantinib + nivolumab +/- ipilimumab (CaboNivo +/- Ipi)

Author

Nicholas I. Simon, Katherine Lei, Nicholas Peter Verdini, Jeffrey Lin, Andy Vega, Scot Anthony Niglio, Amir Mortazavi, Sumanta K. Pal, Jeffrey Kempf, Murray Becker, Michael V. Knopp, Chadwick Wright, Alex Jung, Peter L. Choyke, Seth M. Steinberg, Esther Mena, Liza Lindenberg, and Andrea B. Apolo

Subjects
Cancer Research, Oncology
Abstract

452 Background: This study determined the association of functional imaging parameters obtained on FDG PET/CT and NaF PET/CT with OS for pts with mGU malignancies treated on a phase I study with CaboNivo +/- Ipi. Methods: Pts on this phase I study underwent sequential (1-hour apart) FDG PET/CT and NaF PET/CT imaging at baseline and at first-restaging (8 weeks follow up). Scan semi-quantitative parameters measures included: maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for FDG and MTV for NaF. Total lesion number was captured for all scans. The association of imaging parameters and survival was determined with Kaplan-Meier curves. Baseline values and percent change values were calculated. Results: 81 pts were included in the analysis. 67 (83%) were males; Median age was 63 (range 25-86); Histologically, 30 pts had urothelial carcinoma, 15 clear cell renal cell carcinoma, 9 germ cell tumors, 8 urachal/adenocarcinoma, 8 prostate cancer, 3 penile cancer, 3 squamous cell carcinoma, 3 renal medullary carcinoma, and 2 small cell (1 bladder, 1 prostate). All 81 had a baseline FDG PET scan, 78 pts received baseline NaF PET scans; 66 received both FDG PET and NaF PET baseline and follow up scans. 957 total lesions were detected on FDG PET across all histologies, 87 liver (9%), 252 lung (26%), 152 bone (16%), 411 lymph node (43%), and 55 other visceral metastases (6%). 414 total lesions were detected on NaF imaging. Low vs high baseline FDG MTV (31 vs 11 months, p = 0.0002), TLG (30 vs 11 months, p = 0.0004), Lesion number (49 vs 15 months, p = 0.0005), and SUVmax (25 vs 12 months, p = 0.025), FDG lesion number decrease or no change vs increase (24 vs 12 months, p = 0.0068), and low vs high baseline NaF MTV (26 vs 16 months, p = 0.007), and lesion number (26 vs 16 months, p = 0.007) showed the strongest associations with OS. A multivariable Cox analysis demonstrated that baseline FDG MTV (HR = 2.87, 95% CI 1.62-5.08, p = 0.0003) and FDG lesion number percent change (HR = 2.71, 95% CI 1.40-5.24, p = 0.0031) were jointly associated with OS. Conclusions: Baseline functional imaging parameters and percent change seen on follow imaging with FDG PET and NaF PET are prognostic in mGU pts treated with CaboNivo +/- ipi. Additional parameters and histologic subsets will be presented.

Published
2022
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186. Post-landing major element quantification using SuperCam laser induced breakdown spectroscopy

Author

Ryan B. Anderson, Olivier Forni, Agnes Cousin, Roger C. Wiens, Samuel M. Clegg, Jens Frydenvang, Travis S.J. Gabriel, Ann Ollila, Susanne Schröder, Olivier Beyssac, Erin Gibbons, David S. Vogt, Elise Clavé, Jose-Antonio Manrique, Carey Legett, Paolo Pilleri, Raymond T. Newell, Joseph Sarrao, Sylvestre Maurice, Gorka Arana, Karim Benzerara, Pernelle Bernardi, Sylvain Bernard, Bruno Bousquet, Adrian J. Brown, César Alvarez-Llamas, Baptiste Chide, Edward Cloutis, Jade Comellas, Stephanie Connell, Erwin Dehouck, Dorothea M. Delapp, Ari Essunfeld, Cecile Fabre, Thierry Fouchet, Cristina Garcia-Florentino, Laura García-Gómez, Patrick Gasda, Olivier Gasnault, Elisabeth M. Hausrath, Nina L. Lanza, Javier Laserna, Jeremie Lasue, Guillermo Lopez, Juan Manuel Madariaga, Lucia Mandon, Nicolas Mangold, Pierre-Yves Meslin, Anthony E. Nelson, Horton Newsom, Adriana L. Reyes-Newell, Scott Robinson, Fernando Rull, Shiv Sharma, Justin I. Simon, Pablo Sobron, Imanol Torre Fernandez, Arya Udry, Dawn Venhaus, Scott M. McLennan, Richard V. Morris, Bethany Ehlmann, US Geological Survey [Flagstaff], United States Geological Survey [Reston] (USGS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Los Alamos National Laboratory (LANL), Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), DLR Institute of Optical Sensor Systems, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Universidad de Valladolid [Valladolid] (UVa), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plancius Research LLC, Universidad de Málaga [Málaga] = University of Málaga [Málaga], University of Manitoba [Winnipeg], Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), GeoRessources, Institut national des sciences de l'Univers (INSU - CNRS)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Nevada [Las Vegas] (WGU Nevada), Laboratoire de Planétologie et Géosciences [UMR_C 6112] (LPG), Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), The University of New Mexico [Albuquerque], University of Hawai‘i [Mānoa] (UHM), NASA Johnson Space Center (JSC), NASA, Search for Extraterrestrial Intelligence Institute (SETI), State University of New York at Stony Brook, Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Division of Geological and Planetary Sciences [Pasadena], and California Institute of Technology (CALTECH)

Subjects
LIBS, Mars, Multivariate regression, Laser induced breakdown spectroscopy, Regression, Atomic and Molecular Physics, and Optics, Analytical Chemistry, [SDU]Sciences of the Universe [physics], Calibration, Chemometrics, Laser induced breakdown spectroscopy LIBS Mars Multivariate regression Regression Chemometrics Calibration, Instrumentation, Spectroscopy
Abstract

International audience; The SuperCam instrument on the Perseverance Mars 2020 rover uses a pulsed 1064 nm laser to ablate targets at a distance and conduct laser induced breakdown spectroscopy (LIBS) by analyzing the light from the resulting plasma. SuperCam LIBS spectra are preprocessed to remove ambient light, noise, and the continuum signal present in LIBS observations. Prior to quantification, spectra are masked to remove noisier spectrometer regions and spectra are normalized to minimize signal fluctuations and effects of target distance. In some cases, the spectra are also standardized or binned prior to quantification. To determine quantitative elemental compositions of diverse geologic materials at Jezero crater, Mars, we use a suite of 1198 laboratory spectra of 334 well-characterized reference samples. The samples were selected to span a wide range of compositions and include typical silicate rocks, pure minerals (e.g., silicates, sulfates, carbonates, oxides), more unusual compositions (e.g., Mn ore and sodalite), and replicates of the sintered SuperCam calibration targets (SCCTs) onboard the rover. For each major element (SiO2, TiO2, Al2O3, FeOT, MgO, CaO, Na2O, K2O), the database was subdivided into five "folds" with similar distributions of the element of interest. One fold was held out as an independent test set, and the remaining four folds were used to optimize multivariate regression models relating the spectrum to the composition. We considered a variety of models, and selected several for further investigation for each element, based primarily on the root mean squared error of prediction (RMSEP) on the test set, when analyzed at 3 m. In cases with several models of comparable performance at 3 m, we incorporated the SCCT performance at different distances to choose the preferred model. Shortly after landing on Mars and collecting initial spectra of geologic targets, we selected one model per element. Subsequently, with additional data from geologic targets, some models were revised to ensure results that are more consistent with geochemical constraints. The calibration discussed here is a snapshot of an ongoing effort to deliver the most accurate chemical compositions with SuperCam LIBS.

Published
2022
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187. CRT-100.52 Clinical Outcomes of PCI With a Zotarolimus-Eluting Stent Followed by One-Month DAPT in High-Bleeding-Risk Patients With Small (≤2.5 mm) Coronary Arteries: One-Year Analysis From the Onyx ONE Clear Study

Author

Raul Moreno, David Kandzari, Ajay Kirtane, Stephan Windecker, Azeem Latib, Elvin Kedhi, Roxana Mehran, Mathew J. Price, Daniel I. Simon, Stephen G. Worthley, Te-Hsin Lung, Cecile Mahoney, and Gregg W. Stone

Subjects
Cardiology and Cardiovascular Medicine
Published
2022
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188. Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest

Author

Neha eDixit and Scott I Simon

Subjects
Calcium, Cytoskeletal Proteins, Inflammation, Neutrophils, chemokine, Integrin affinity, Immunologic diseases. Allergy, RC581-607
Abstract

Leukocyte trafficking to acute sites of injury or infection requires spatial and temporal cues that fine tune precise sites of firm adhesion and guide migration to endothelial junctions where they undergo diapedesis to sites of insult. Many detailed studies on the location and gradient of chemokines such as IL-8 and other CXCR ligands reveal that their recognition shortly after selectin-mediated capture and rolling exerts acute effects on integrin activation and subsequent binding to their ligands on the endothelium, which directs firm adhesion, adhesion strengthening and downstream migration.. In this process, GPCR signaling has been found to play an integral role in activating and mobilizing intracellular stores of calcium, GTPases such as Rap-1 and Rho and cytokeletal proteins such as Talin and F-actin to facilitate cell polarity and directional pseudopod formation. A critical question remaining is how intracellular Ca2+ flux from CRAC channels such as Orai1 synergizes with cytosolic stores to mediate a rapid flux which is critical to the onset of PMN arrest and polarization. Our review will highlight a specific role for calcium as a signaling messenger in activating focal clusters of integrins bound to the cytoskeleton which allows the cell to attain a migratory phenotype. The precise interplay between chemokines, selectins, and integrins binding under the ubiqutious presence of shear stress from blood flow provides an essential cooperative signaling mechanism for effective leukocyte recruitment.

Published
2012
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189. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.

Author

John S Cho, Yi Guo, Romela Irene Ramos, Frank Hebroni, Seema B Plaisier, Caiyun Xuan, Jennifer L Granick, Hironori Matsushima, Akira Takashima, Yoichiro Iwakura, Ambrose L Cheung, Genhong Cheng, Delphine J Lee, Scott I Simon, and Lloyd S Miller

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the S. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and IL-1β/IL-1R activation. Unexpectedly, neutrophils but not monocytes/macrophages or other MHCII-expressing antigen presenting cells were the predominant source of IL-1β at the site of infection. Furthermore, neutrophil-derived IL-1β was essential for host defense since adoptive transfer of IL-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in S. aureus-infected IL-1β-deficient mice. S. aureus-induced IL-1β production by neutrophils required TLR2, NOD2, FPR1 and the ASC/NLRP3 inflammasome in an α-toxin-dependent mechanism. Taken together, IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1β production by neutrophils.

Published
2012
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190. A Human-Centered Approach to CV Care

Author

Ankur Kalra, John Omagino, Marco A. Costa, Daniel I. Simon, Robert A. Salata, Moses R. Kamya, Allison R. Webel, Emmy Okello, Cissy Kityo, Peter Lwabi, and Chris T. Longenecker

Subjects
Community and Home Care, Heart disease, Epidemiology, business.industry, media_common.quotation_subject, AIDS Care, Cardiovascular care, 030204 cardiovascular system & hematology, University hospital, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Excellence, Heart failure, Medicine, Community awareness, Maternal health, 030212 general & internal medicine, Medical emergency, Cardiology and Cardiovascular Medicine, business, media_common
Abstract

In this case study, we describe an ongoing approach to develop sustainable acute and chronic cardiovascular care infrastructure in Uganda that involves patient and provider participation. Leveraging strong infrastructure for HIV/AIDS care delivery, University Hospitals Harrington Heart and Vascular Institute and Case Western Reserve University have partnered with U.S. and Ugandan collaborators to improve cardiovascular capabilities. The collaboration has solicited innovative solutions from patients and providers focusing on education and advanced training, penicillin supply, diagnostic strategy (e.g., hand-held ultrasound), maternal health, and community awareness. Key outcomes of this approach have been the completion of formal training of the first interventional cardiologists and heart failure specialists in the country, establishment of 4 integrated regional centers of excellence in rheumatic heart disease care with a national rheumatic heart disease registry, a penicillin distribution and adherence support program focused on retention in care, access to imaging technology, and in-country capabilities to treat advanced rheumatic heart valve disease.

Published
2018
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191. Impact of Right Ventricular Pacing in Patients Who Underwent Implantation of Permanent Pacemaker After Transcatheter Aortic Valve Implantation

Author

Rahul Thomas, Sandeep M. Patel, Takahiro Tsushima, Judith A. Mackall, Toral R. Patel, Ankur Kalra, Guillherme F. Attizzani, Marco A. Costa, Daniel I. Simon, Jerry Lipinski, Fahd Nadeem, Sergio Thal, Jun Li, Mauricio Arruda, Petar Saric, and Thomas Ladas

Subjects
Adult, Male, Pacemaker, Artificial, medicine.medical_specialty, Transcatheter aortic, Heart Ventricles, 030204 cardiovascular system & hematology, Transcatheter Aortic Valve Replacement, Electrocardiography, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Cause of Death, Internal medicine, medicine, Humans, Registries, 030212 general & internal medicine, Aged, Ohio, Retrospective Studies, Aged, 80 and over, business.industry, Incidence, Hazard ratio, Arrhythmias, Cardiac, Aortic Valve Stenosis, Middle Aged, Ventricular pacing, Prognosis, medicine.disease, Confidence interval, Survival Rate, Heart failure, Cohort, Ventricular Function, Right, Cardiology, Female, Permanent pacemaker, Cardiology and Cardiovascular Medicine, Complication, business, Follow-Up Studies
Abstract

Atrioventricular conduction disturbances requiring implantation of permanent pacemaker (PPM) are a common complication following transcatheter aortic valve implantation (TAVI). Previous registry data are conflicting but suggestive of an increased risk in heart failure admissions in the post-TAVI PPM cohort. Given the expanding use of TAVI, the present study evaluates the effects of chronic right ventricular pacing (RV pacing) in post-TAVI patients. This is a single-center study of 672 patients who underwent TAVI from 2011 to 2017 of which 146 underwent PPM. Follow-up 1-year post-TAVI outcome data were available for 55 patients and were analyzed retrospectively. Patients who underwent PPM were more likely to have heart failure admissions (17.1% vs 10.1%; hazard ratio [HR] 1.70; 95% confidence interval [CI] 1.10 to 2.64; p 0.019) and a trend toward increased mortality (21.9% vs 15.4%; HR 1.42; 95% CI 0.99 to 2.05; p 0.062). At 1-year follow-up, 30 of 55 (54.5%) patients demonstrated40% RV pacing. Compared with patients who had40% RV pacing, those with40% RV pacing were more likely to have heart failure admissions (8% vs 40%; HR 5.0; 95% CI 1.23 to 20.27; p 0.007) and demonstrated a trend toward increased mortality (12% vs 33.3%; HR 2.78; 95% CI 0.86 to 9.00; p 0.064). This is suggestive that the post-TAVI PPM cohort is particularly sensitive to chronic RV pacing.

Published
2018
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192. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17

Author

Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. (Shally), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azman, A. S. (Andrew S.), Babaee, E. (Ebrahim), Badawi, A. (Alaa), Bagherzadeh, M. (Mojtaba), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barboza, M. A. (Miguel A.), Barnighausen, T. W. (Till Winfried), Basu, S. (Sanjay), . (), Bayati, M. (Mohsen), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Meysam), Behzadifar, M. (Masoud), Ramirez, D. F. (Diana Fernanda Bejarano), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Benzian, H. (Habib), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Bin Sayeed, M. S. (Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), Reiner, R. C. (Robert C., Jr.), Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. 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(Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), and Reiner, R. C. (Robert C., Jr.)

Abstract

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0)

Published
2020

193. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019:a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author

Wang, H. (Haidong), Abbas, K. M. (Kaja M.), Abbasifard, M. (Mitra), Abbasi-Kangevari, M. (Mohsen), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abolhassani, H. (Hassan), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abushouk, A. I. (Abdelrahman I.), Adabi, M. (Maryam), Adair, T. (Tim), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adekanmbi, V. (Victor), Adeoye, A. M. (Abiodun Moshood), Adetokunboh, O. O. (Olatunji O.), Advani, S. M. (Shailesh M.), Afshin, A. (Ashkan), Aghaali, M. (Mohammad), Agrawal, A. (Anurag), Ahmadi, K. (Keivan), Ahmadieh, H. (Hamid), Ahmed, M. B. (Muktar Beshir), Al-Aly, Z. (Ziyad), Alam, K. (Khurshid), Alam, T. (Tahiya), Alanezi, F. M. (Fahad Mashhour), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, M. (Muhammad), Alicandro, G. (Gianfranco), Alijanzadeh, M. (Mehran), Alinia, C. (Cyrus), Alipour, V. (Vahid), Alizade, H. (Hesam), Aljunid, S. M. (Syed Mohamed), Allebeck, P. (Peter), Almadi, M. A. (Majid Abdulrahman Hamad), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alumran, A. K. (Arwa Khalid), Alvis-Guzman, N. (Nelson), Amini-Rarani, M. (Mostafa), Aminorroaya, A. (Arya), Amit, A. M. (Arianna Maever L.), Ancuceanu, R. (Robert), Andrei, C. L. (Catalina Liliana), Androudi, S. (Sofia), Angus, C. (Colin), Anjomshoa, M. (Mina), Ansari, F. (Fereshteh), Ansari, I. (Iman), Ansari-Moghaddam, A. (Alireza), Antonio, C. A. (Carl Abelardo T.), Antony, C. M. (Catherine M.), Anvari, D. (Davood), Appiah, S. C. (Seth Christopher Yaw), Arabloo, J. (Jalal), Arab-Zozani, M. (Morteza), Aravkin, A. Y. (Aleksandr Y.), Aremu, O. (Olatunde), Arnlov, J. (Johan), Aryal, K. K. (Krishna K.), Asadi-Pooya, A. A. (Ali A.), Asgari, S. (Samaneh), Jafarabadi, M. A. (Mohammad Asghari), Atteraya, M. S. (Madhu Sudhan), Ausloos, M. (Marcel), Avila-Burgos, L. (Leticia), Avokpaho, E. F. (Euripide Frinel Gbenato Arthur), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Azarian, G. (Ghasem), Babaee, E. (Ebrahim), Badiye, A. D. (Ashish D.), Bagli, E. (Eleni), Bahrami, M. A. (Mohammad Amin), Bakhtiari, A. (Ahad), Balassyano, S. (Shelly), Banach, M. (Maciej), Banik, P. C. (Palash Chandra), Barker-Collo, S. L. (Suzanne Lyn), Barnighausen, T. W. (Till Winfried), Barzegar, A. (Akbar), Basu, S. (Sanjay), Baune, B. T. (Bernhard T.), Bayati, M. (Mohsen), Bazmandegan, G. (Gholamreza), Bedi, N. (Neeraj), Bell, M. L. (Michellr L.), Bennett, D. A. (Derrick A.), Bensenor, I. M. (Isabela M.), Berhe, K. (Kidanemaryam), Berman, A. E. (Adam E.), Bertolacci, G. J. (Gregory J.), Bhageerathy, R. (Reshmi), Bhala, N. (Neeraj), Bhattacharyya, K. (Krittika), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Biondi, A. (Antonio), Bisanzio, D. (Donal), Bisignano, C. (Catherine), Biswas, R. K. (Raaj Kishore), Bjrge, T. (Tone), Bohlouli, S. (Somayeh), Bohluli, M. (Mehdi), Bolla, S. R. (Srinivasa Rao Rao), Borzi, A. M. (Antonio Maria), Borzouei, S. (Shiva), Brady, O. J. (Oliver J.), Braithwaite, D. (Dejana), Brauer, M. (Michael), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Bumgarner, B. R. (Blair R.), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), dos Santos, F. L. (Florentino Luciano Caetano), Cai, T. (Tianji), Callender, C. S. (Charlton S. K. H.), Camera, L. L. (Luis L. A. Alberto), Campos-Nonato, I. R. (Ismael R.), Cardenas, R. (Rosario), Carreras, G. (Giulia), Carrero, J. J. (Juan J.), Carvalho, F. (Felix), Castaldelli-Maia, J. M. (Joao Mauricio), Castelpietra, G. (Giulio), Castro, F. (Franz), Catala-Lopez, F. (Ferran), Cederroth, C. R. (Christopher R.), Cerin, E. (Ester), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Chu, D.-T. (Dinh-Toi), Ciobanu, L. G. (Liliana G.), Cirillo, M. (Massimo), Comfort, H. (Haley), Costa, V. M. (Vera Marisa), Cowden, R. G. (Richard G.), Cromwell, E. A. (Elizabeth A.), Croneberger, A. J. (Andrew J.), Cunningham, M. (Matthew), Dahlawi, S. M. (Saad M. A.), Damiani, G. (Giovanni), D'Amico, E. (Emanuele), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dargan, P. I. (Paul I.), Darwesh, A. M. (Aso Mohammad), Daryani, A. (Ahmad), Das Gupta, R. (Rajat), das Neves, J. (Jose), Davletov, K. (Kairat), De Leo, D. (Diego), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Dervenis, N. (Nikolaos), Desai, R. (Rupak), Dhungana, G. P. (Govinda Prasad), da Silva, D. D. (Diana Dias), Diaz, D. (Daniel), Dippenaar, I. N. (Ilse N.), Djalalinia, S. (Shirin), Do, H. T. (Hoa Thi), Dokova, K. (Klara), Doku, D. T. (David Teye), Dorostkar, F. (Fariba), Doshi, C. P. (Chirag P.), Doshmangir, L. (Leila), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edvardsson, D. (David), Effiong, A. (Andem), El Sayed, I. (Iman), El Tantawi, M. (Maha), Elbarazi, I. (Iffat), El-Jaafary, S. I. (Shaimaa I.), Emamian, M. H. (Mohammad Hassan), Eskandarieh, S. (Sharareh), Esmaeilzadeh, F. (Firooz), Estep, K. (Kara), Farahmand, M. (Mohammad), Faraj, A. (Anwar), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Faro, A. (Andre), Farzadfar, F. (Farshad), Fattahi, N. (Nazir), Fazaeli, A. A. (Ali Akbar), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Ferreira, M. L. (Manuela L.), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Fomenkov, A. A. (Artem Alekseevich), Freitas, M. (Marisa), Fukumoto, T. (Takeshi), Fuller, J. E. (John E.), Furtado, J. M. (Joao M.), Gad, M. M. (Mohamed M.), Gakidou, E. (Emmanuela), Gallus, S. (Silvano), Gebrehiwot, A. M. (Abiyu Mekonnen), Gebremedhin, K. B. (Ketema Bizuwork), Gething, P. W. (Peter W.), Ghamari, F. (Farhad), Ghashghaee, A. (Ahmad), Gholamian, A. (Asadollah), Gilani, S. A. (Syed Amir), Gitimoghaddam, M. (Mojgan), Glushkova, E. V. (Ekaterina Vladimirovna), Gnedovskaya, E. V. (Elena V.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Gugnani, H. C. (Harish Chander), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, S. S. (Subodh Sharan), Haagsma, J. A. (Juanita A.), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Halvaei, I. (Iman), Hamadeh, R. R. (Randah R.), Abdullah, K. H. (Kanaan Hamagharib), Han, C. (Chieh), Handiso, D. W. (Demelash Woldeyohannes), Hankey, G. J. (Graeme J.), Haririan, H. (Hamidreza), Haro, J. M. (Josep Maria), Hasaballah, A. I. (Ahmed I.), Hassanipour, S. (Soheil), Hassankhani, H. (Hadi), Hay, S. I. (Simon I.), Heibati, B. (Behzad), Heidari-Soureshjani, R. (Reza), Henny, K. (Kiana), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), Hole, M. K. (Michael K.), Hoogar, P. (Praveen), Hosgood, H. D. (H. Dean), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Hostiuc, M. (Mihaela), Hostiuc, S. (Sorin), Househ, M. (Mowafa), Hoy, D. G. (Damian G.), Hu, G. (Guoqing), Huda, T. M. (Tanvir M.), Ibitoye, S. E. (Segun Emmanuel), Ikuta, K. S. (Kevin S.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, I. M. (Irena M.), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Islam, M. (MdMohaimenul), Iso, H. (Hiroyasu), Iwu, C. J. (Chinwe Juliana), Jaafari, J. (Jalil), Jacobsen, K. H. (Kathryn H.), Jahagirdar, D. (Deepa), Jahanmehr, N. (Nader), Jalali, A. (Amir), Jalilian, F. (Farzad), James, S. L. (Spencer L.), Janjani, H. (Hosna), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Joukar, F. (Farahnaz), Jozwiak, J. J. (Jacek Jerzy), Jurisson, M. (Mikk), Kabir, Z. (Zubair), Kalani, H. (Hamed), Kalankesh, L. R. (Leila R.), Kamiab, Z. (Zahra), Kanchan, T. (Tanuj), Kapoor, N. (Neeti), Karch, A. (Andre), Karimi, S. E. (Salah Eddin), Karimi, S. A. (Seyed Asaad), Kassebaum, N. J. (Nicholas J.), Katikireddi, S. V. (Srinivasa Vittal), Kawakami, N. (Norito), Kayode, G. A. (Gbenga A.), Keiyoro, P. N. (Peter Njenga), Keller, C. (Cathleen), Khader, Y. S. (Yousef Saleh), Khalid, N. (Nauman), Khan, E. A. (Ejaz Ahmad), Khan, M. (Maseer), Khang, Y.-H. (Young-Ho), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khazaei, S. (Salman), Khazaie, H. (Habibolah), Khodayari, M. T. (Mohammad Taghi), Khubchandani, J. (Jagdish), Kianipour, N. (Neda), Kim, C.-i. (Cho-il), Kim, Y.-E. (Young-Eun), Kim, Y. J. (Yun Jin), Kinfu, Y. (Yohannes), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissimova-Skarbek, K. (Katarzyna), Kivimaki, M. (Mika), Komaki, H. (Hamidreza), Kopec, J. A. (Jacek A.), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kravchenko, M. A. (Michael A.), Krishan, K. (Kewal), Krohn, K. J. (Kris J.), Defo, B. K. (Barthelemy Kuate), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kumar, V. (Vivek), Kusuma, D. (Dian), Kyu, H. H. (Hmwe Hmwe), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, D. K. (Dharmesh Kumar), Lalloo, R. (Ratilal), Lami, F. H. (Faris Hasan), Lansky, S. (Sonia), Larson, S. L. (Samantha Leigh), Larsson, A. O. (Anders O.), Lasrado, S. (Savita), Lassi, Z. S. (Zohra S.), Lazarus, J. V. (Jeffrey V.), Lee, P. H. (Paul H.), Lee, S. W. (Shaun Wen Huey), Leever, A. T. (Andrew T.), LeGrand, K. E. (Kate E.), Leonardi, M. (Matilde), Li, S. (Shanshan), Lim, L.-L. (Lee-Ling), Lim, S. S. (Stephen S.), Linn, S. (Shai), Lodha, R. (Rakesh), Logroscino, G. (Giancarlo), Lopez, A. D. (Alan D.), Lopukhov, P. D. (Platon D.), Lotufo, P. A. (Paulo A.), Lozano, R. (Rafael), Lu, A. (Alton), Lunevicius, R. (Raimundas), Madadin, M. (Mohammed), Maddison, E. R. (Emilie R.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Mahasha, P. W. (Phetole Walter), Mahdavi, M. M. (Mokhtar Mahdavi), Malekzadeh, R. (Reza), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansour-Ghanaei, F. (Fariborz), Mansouri, B. (Borhan), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Mastrogiacomo, C. I. (Claudia I.), Mathur, M. R. (Manu Raj), May, E. A. (Erin A.), McAlinden, C. (Colm), McGrath, J. J. (John J.), McKee, M. (Martin), Mehndiratta, M. M. (Man Mohan), Mehri, F. (Fereshteh), Mehta, K. M. (Kala M.), Meitei, W. B. (Wahengbam Bigyananda), Memiah, P. T. (Peter T. N.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mengesha, E. W. (Endalkachew Worku), Mensah, G. A. (George A.), Meretoja, A. (Atte), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Michalek, I. M. (Irmina Maria), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mills, E. J. (Edward J.), Milne, G. J. (George J.), Mirrakhimov, E. M. (Erkin M.), Mirzaei, H. (Hamed), Mirzaei, M. (Maryam), Mirzaei-Alavijeh, M. (Mehdi), Misganaw, A. T. (Awoke Temesgen), Moazen, B. (Babak), Moghadaszadeh, M. (Masoud), Mohamadi, E. (Efat), Mohammad, D. K. (Dara K.), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadbeigi, A. (Abolfazl), Mohammadian-Hafshejani, A. (Abdollah), Mohammadpourhodki, R. (Reza), Mohammed, H. (Hussen), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Bandpei, M. A. (Mohammad A. Mohseni), Mokari, A. (Amin), Mokdad, A. H. (Ali H.), Momen, N. C. (Natalie C.), Monasta, L. (Lorenzo), Mooney, M. D. (Meghan D.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moradzadeh, R. (Rahmatollah), Moraga, P. (Paula), Velasquez, I. M. (Ilais Moreno), Morgado-da-Costa, J. (Joana), Morrison, S. D. (Shane Douglas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Khaneghah, A. M. (Amin Mousavi), Mueller, U. O. (Ulrich Otto), Musa, K. I. (Kamarul Imran), Muthupandian, S. (Saravanan), Nabavizadeh, B. (Behnam), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naghshtabrizi, B. (Behshad), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Negoi, R. I. (Ruxandra Irina), Ngunjiri, J. W. (Josephine W.), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, Y. T. (Yeshambel T.), Nikbakhsh, R. (Rajan), Nikpoor, A. R. (Amin Reza), Nixon, M. R. (Molly R.), Nnaji, C. A. (Chukwudi A.), Nomura, S. (Shuhei), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Nowak, C. (Christoph), Otoiu, A. (Adrian), Odell, C. M. (Christopher M.), Oh, I.-H. (In-Hwan), Oladnabi, M. (Morteza), Olagunju, A. T. (Andrew T.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Bali, A. O. (Ahmed Omar), Ong, K. L. (Kanyin L.), Onwujekwe, O. E. (Obinna E.), Ortiz, A. (Alberto), Otstavnov, N. (Nikita), Otstavnov, S. S. (Stanislav S.), Overland, S. (Simon), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakshir, K. (Keyvan), Palladino, R. (Raffaele), Pana, A. (Adrian), Panda-Jonas, S. (Songhomitra), Park, J. (James), Pasupula, D. K. (Deepak Kumar), Patel, J. R. (Jenil R.), Patel, S. K. (Sangram Kishor), Patton, G. C. (George C.), Paulson, K. R. (Katherine R.), Toroudi, H. P. (Hamidreza Pazoki), Pease, S. A. (Spencer A.), Peden, A. E. (Amy E.), Pepito, V. C. (Veincent Christian Filipino), Peprah, E. K. (Emmanuel K.), Pereira, A. (Alexandre), Pereira, D. M. (David M.), Perico, N. (Norberto), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pilz, T. M. (Tessa M.), Piradov, M. A. (Michael A.), Pirsaheb, M. (Meghdad), Pokhrel, K. N. (Khem Narayan), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poznanska, A. (Anna), Prada, S. I. (Sergio I.), Prakash, S. (Sanjay), Preotescu, L. (Liliana), Syed, Z. Q. (Zahiruddin Quazi), Rabiee, M. (Mohammad), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Raggi, A. (Alberto), Rahman, M. A. (Muhammad Aziz), Rajabpour-Sanati, A. (Ali), Ram, P. (Pradhum), Ranabhat, C. L. (Chhabi Lal), Rao, S. J. (Sowmya J.), Rasella, D. (Davide), Rashedi, V. (Vahid), Rastogi, P. (Prateek), Rathi, P. (Priya), Rawal, L. (Lal), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Rezaei, N. (Nima), Rezai, M. s. (Mohammad sadegh), Rezapour, A. (Aziz), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Roshandel, G. (Gholamreza), Rostamian, M. (Morteza), Rubagotti, E. (Enrico), Rwegerera, G. M. (Godfrey M.), Sabour, S. (Siamak), Saddik, B. (Basema), Sadeghi, E. (Ehsan), Sadeghi, M. (Masoumeh), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Safi, S. (Sare), Safiri, S. (Saeid), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salama, J. S. (Joseph S.), Salamati, P. (Payman), Salem, M. R. (Marwa R. Rashad), Salimi, Y. (Yahya), Salomon, J. A. (Joshua A.), Salz, I. (Inbal), Samad, Z. (Zainab), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sartorius, B. (Benn), Sarveazad, A. (Arash), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sattin, D. (Davide), Saylan, M. (Mete), Schaeffer, L. E. (Lauren E.), Schiavolin, S. (Silvia), Schwebel, D. C. (David C.), Schwendicke, F. (Falk), Sekerija, M. (Mario), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabani, M. (Mahsima), Shahabi, S. (Saeed), Shahbaz, M. (Mohammad), Shaheen, A. A. (Amira A.), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharafi, Z. (Zeinab), Sharara, F. (Fablina), Sharma, R. (Rajesh), Shaw, D. H. (David H.), Sheikh, A. (Aziz), Il Shin, J. (Jae), Shiri, R. (Rahman), Shrime, M. G. (Mark G.), Shuval, K. (Kerem), Siabani, S. (Soraya), Sigfusdottir, I. D. (Inga Dora), Sigurvinsdottir, R. (Rannveig), Silva, D. A. (Diego Augusto Santos), Simonetti, B. (Biagio), Simpson, K. E. (Kyle E.), Singh, J. A. (Jasvinder A.), Skiadaresi, E. (Eirini), Skryabin, V. Y. (Valentin Yurievich), Soheili, A. (Amin), Sokhan, A. (Anton), Sorensen, R. J. (Reed J. D.), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Stockfelt, L. (Leo), Stokes, M. A. (Mark A.), Stubbs, J. L. (Jacob L.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Abdulkader, R. S. (Rizwan Suliankatchi), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabb, K. M. (Karen M.), Tadakamadla, S. K. (Santosh Kumar), Taherkhani, A. (Amir), Tang, M. (Muming), Taveira, N. (Nuno), Taylor, H. J. (Heather Jean), Teagle, W. L. (Whitney L.), Tehrani-Banihashemi, A. (Arash), Teklehaimanot, B. F. (Berhane Fseha), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Thrift, A. G. (Amanda G.), Titova, M. V. (Mariya Vladimirovna), Tohidinik, H. R. (Hamid Reza), Tonelli, M. (Marcello), Topor-Madry, R. (Roman), Topouzis, F. (Fotis), Tovani-Palone, M. R. (Marcos Roberto Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Travillian, R. (Ravensara), Trias-Llimos, S. (Sergi), Truelsen, T. C. (Thomas Clement), Car, L. T. (Lorainne Tudor), Unnikrishnan, B. (Bhaskaran), Upadhyay, E. (Era), Vacante, M. (Marco), Vakilian, A. (Alireza), Valdez, P. R. (Pascual R.), Valli, A. (Alessandro), Vardavas, C. (Constantine), Vasankari, T. J. (Tommi Juhani), Vasconcelos, A. M. (Ana Maria Nogales), Vasseghian, Y. (Yasser), Veisani, Y. (Yousef), Venketasubramanian, N. (Narayanaswamy), Vidale, S. (Simone), Violante, F. S. (Francesco S.), Vlassov, V. (Vasily), Vollset, S. E. (Stein Emil), Vos, T. (Theo), Vujcic, I. S. (Isidora S.), Vukovic, A. (Ana), Vukovic, R. (Rade), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Walters, M. K. (Magdalene K.), Wang, H. (Hongbo), Wang, Y.-P. (Yuan-Pang), Watson, S. (Stefanie), Wei, J. (Jingkai), Weiss, J. (Jordan), Weldesamuel, G. T. (Girmay Teklay), Werdecker, A. (Andrea), Westerman, R. (Ronny), Whiteford, H. A. (Harvey A.), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wojtyniak, B. (Bogdan), Wolfe, C. D. (Charles D. A.), Wondmieneh, A. B. (Adam Belay), Wool, E. E. (Eve E.), Wu, A.-M. (Ai-Min), Wu, J. (Junjie), Xu, G. (Gelin), Yamada, T. (Tomohide), Yamagishi, K. (Kazumasa), Yano, Y. (Yuichiro), Yaya, S. (Sanni), Yazdi-Feyzabadi, V. (Vahid), Yearwood, J. A. (Jamal A.), Yeheyis, T. Y. (Tomas Y.), Yilgwan, C. S. (Christopher Sabo), Yip, P. (Paul), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Lebni, J. Y. (Javad Yoosefi), York, H. W. (Hunter W.), Younis, M. Z. (Mustafa Z.), Younker, T. P. (Theodore Patrick), Yousefi, Z. (Zabihollah), Yousefinezhadi, T. (Taraneh), Yousuf, A. Y. (Abdilahi Yousuf), Yusefzadeh, H. (Hasan), Moghadam, T. Z. (Telma Zahirian), Zakzuk, J. (Josefina), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zamanian, M. (Maryam), Zandian, H. (Hamed), Zhang, Z.-J. (Zhi-Jiang), Zheng, P. (Peng), Zhou, M. (Maigeng), Ziapour, A. (Arash), Murray, C. J. (Christopher J. L.), Wang, H. (Haidong), Abbas, K. M. (Kaja M.), Abbasifard, M. (Mitra), Abbasi-Kangevari, M. (Mohsen), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abolhassani, H. (Hassan), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abushouk, A. I. (Abdelrahman I.), Adabi, M. (Maryam), Adair, T. (Tim), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adekanmbi, V. (Victor), Adeoye, A. M. (Abiodun Moshood), Adetokunboh, O. O. (Olatunji O.), Advani, S. M. (Shailesh M.), Afshin, A. (Ashkan), Aghaali, M. (Mohammad), Agrawal, A. (Anurag), Ahmadi, K. (Keivan), Ahmadieh, H. (Hamid), Ahmed, M. B. (Muktar Beshir), Al-Aly, Z. (Ziyad), Alam, K. (Khurshid), Alam, T. (Tahiya), Alanezi, F. M. (Fahad Mashhour), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, M. (Muhammad), Alicandro, G. (Gianfranco), Alijanzadeh, M. (Mehran), Alinia, C. (Cyrus), Alipour, V. (Vahid), Alizade, H. (Hesam), Aljunid, S. M. (Syed Mohamed), Allebeck, P. (Peter), Almadi, M. A. (Majid Abdulrahman Hamad), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alumran, A. K. (Arwa Khalid), Alvis-Guzman, N. (Nelson), Amini-Rarani, M. (Mostafa), Aminorroaya, A. (Arya), Amit, A. M. (Arianna Maever L.), Ancuceanu, R. (Robert), Andrei, C. L. (Catalina Liliana), Androudi, S. (Sofia), Angus, C. (Colin), Anjomshoa, M. (Mina), Ansari, F. (Fereshteh), Ansari, I. (Iman), Ansari-Moghaddam, A. (Alireza), Antonio, C. A. (Carl Abelardo T.), Antony, C. M. (Catherine M.), Anvari, D. (Davood), Appiah, S. C. (Seth Christopher Yaw), Arabloo, J. (Jalal), Arab-Zozani, M. (Morteza), Aravkin, A. Y. (Aleksandr Y.), Aremu, O. (Olatunde), Arnlov, J. (Johan), Aryal, K. K. (Krishna K.), Asadi-Pooya, A. A. (Ali A.), Asgari, S. (Samaneh), Jafarabadi, M. A. (Mohammad Asghari), Atteraya, M. S. (Madhu Sudhan), Ausloos, M. (Marcel), Avila-Burgos, L. (Leticia), Avokpaho, E. F. (Euripide Frinel Gbenato Arthur), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Azarian, G. (Ghasem), Babaee, E. (Ebrahim), Badiye, A. D. (Ashish D.), Bagli, E. (Eleni), Bahrami, M. A. (Mohammad Amin), Bakhtiari, A. (Ahad), Balassyano, S. (Shelly), Banach, M. (Maciej), Banik, P. C. (Palash Chandra), Barker-Collo, S. L. (Suzanne Lyn), Barnighausen, T. W. (Till Winfried), Barzegar, A. (Akbar), Basu, S. (Sanjay), Baune, B. T. (Bernhard T.), Bayati, M. (Mohsen), Bazmandegan, G. (Gholamreza), Bedi, N. (Neeraj), Bell, M. L. (Michellr L.), Bennett, D. A. (Derrick A.), Bensenor, I. M. (Isabela M.), Berhe, K. (Kidanemaryam), Berman, A. E. (Adam E.), Bertolacci, G. J. (Gregory J.), Bhageerathy, R. (Reshmi), Bhala, N. (Neeraj), Bhattacharyya, K. (Krittika), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Biondi, A. (Antonio), Bisanzio, D. (Donal), Bisignano, C. (Catherine), Biswas, R. K. (Raaj Kishore), Bjrge, T. (Tone), Bohlouli, S. (Somayeh), Bohluli, M. (Mehdi), Bolla, S. R. (Srinivasa Rao Rao), Borzi, A. M. (Antonio Maria), Borzouei, S. (Shiva), Brady, O. J. (Oliver J.), Braithwaite, D. (Dejana), Brauer, M. (Michael), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Bumgarner, B. R. (Blair R.), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), dos Santos, F. L. (Florentino Luciano Caetano), Cai, T. (Tianji), Callender, C. S. (Charlton S. K. H.), Camera, L. L. (Luis L. A. Alberto), Campos-Nonato, I. R. (Ismael R.), Cardenas, R. (Rosario), Carreras, G. (Giulia), Carrero, J. J. (Juan J.), Carvalho, F. (Felix), Castaldelli-Maia, J. M. (Joao Mauricio), Castelpietra, G. (Giulio), Castro, F. (Franz), Catala-Lopez, F. (Ferran), Cederroth, C. R. (Christopher R.), Cerin, E. (Ester), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Chu, D.-T. (Dinh-Toi), Ciobanu, L. G. (Liliana G.), Cirillo, M. (Massimo), Comfort, H. (Haley), Costa, V. M. (Vera Marisa), Cowden, R. G. (Richard G.), Cromwell, E. A. (Elizabeth A.), Croneberger, A. J. (Andrew J.), Cunningham, M. (Matthew), Dahlawi, S. M. (Saad M. A.), Damiani, G. (Giovanni), D'Amico, E. (Emanuele), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dargan, P. I. (Paul I.), Darwesh, A. M. (Aso Mohammad), Daryani, A. (Ahmad), Das Gupta, R. (Rajat), das Neves, J. (Jose), Davletov, K. (Kairat), De Leo, D. (Diego), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Dervenis, N. (Nikolaos), Desai, R. (Rupak), Dhungana, G. P. (Govinda Prasad), da Silva, D. D. (Diana Dias), Diaz, D. (Daniel), Dippenaar, I. N. (Ilse N.), Djalalinia, S. (Shirin), Do, H. T. (Hoa Thi), Dokova, K. (Klara), Doku, D. T. (David Teye), Dorostkar, F. (Fariba), Doshi, C. P. (Chirag P.), Doshmangir, L. (Leila), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edvardsson, D. (David), Effiong, A. (Andem), El Sayed, I. (Iman), El Tantawi, M. (Maha), Elbarazi, I. (Iffat), El-Jaafary, S. I. (Shaimaa I.), Emamian, M. H. (Mohammad Hassan), Eskandarieh, S. (Sharareh), Esmaeilzadeh, F. (Firooz), Estep, K. (Kara), Farahmand, M. (Mohammad), Faraj, A. (Anwar), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Faro, A. (Andre), Farzadfar, F. (Farshad), Fattahi, N. (Nazir), Fazaeli, A. A. (Ali Akbar), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Ferreira, M. L. (Manuela L.), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Fomenkov, A. A. (Artem Alekseevich), Freitas, M. (Marisa), Fukumoto, T. (Takeshi), Fuller, J. E. (John E.), Furtado, J. M. (Joao M.), Gad, M. M. (Mohamed M.), Gakidou, E. (Emmanuela), Gallus, S. (Silvano), Gebrehiwot, A. M. (Abiyu Mekonnen), Gebremedhin, K. B. (Ketema Bizuwork), Gething, P. W. (Peter W.), Ghamari, F. (Farhad), Ghashghaee, A. (Ahmad), Gholamian, A. (Asadollah), Gilani, S. A. (Syed Amir), Gitimoghaddam, M. (Mojgan), Glushkova, E. V. (Ekaterina Vladimirovna), Gnedovskaya, E. V. (Elena V.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Gugnani, H. C. (Harish Chander), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, S. S. (Subodh Sharan), Haagsma, J. A. (Juanita A.), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Halvaei, I. (Iman), Hamadeh, R. R. (Randah R.), Abdullah, K. H. (Kanaan Hamagharib), Han, C. (Chieh), Handiso, D. W. (Demelash Woldeyohannes), Hankey, G. J. (Graeme J.), Haririan, H. (Hamidreza), Haro, J. M. (Josep Maria), Hasaballah, A. I. (Ahmed I.), Hassanipour, S. (Soheil), Hassankhani, H. (Hadi), Hay, S. I. (Simon I.), Heibati, B. (Behzad), Heidari-Soureshjani, R. (Reza), Henny, K. (Kiana), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), Hole, M. K. (Michael K.), Hoogar, P. (Praveen), Hosgood, H. D. (H. Dean), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Hostiuc, M. (Mihaela), Hostiuc, S. (Sorin), Househ, M. (Mowafa), Hoy, D. G. (Damian G.), Hu, G. (Guoqing), Huda, T. M. (Tanvir M.), Ibitoye, S. E. (Segun Emmanuel), Ikuta, K. S. (Kevin S.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, I. M. (Irena M.), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Islam, M. (MdMohaimenul), Iso, H. (Hiroyasu), Iwu, C. J. (Chinwe Juliana), Jaafari, J. (Jalil), Jacobsen, K. H. (Kathryn H.), Jahagirdar, D. (Deepa), Jahanmehr, N. (Nader), Jalali, A. (Amir), Jalilian, F. (Farzad), James, S. L. (Spencer L.), Janjani, H. (Hosna), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Joukar, F. (Farahnaz), Jozwiak, J. J. (Jacek Jerzy), Jurisson, M. (Mikk), Kabir, Z. (Zubair), Kalani, H. (Hamed), Kalankesh, L. R. (Leila R.), Kamiab, Z. (Zahra), Kanchan, T. (Tanuj), Kapoor, N. (Neeti), Karch, A. (Andre), Karimi, S. E. (Salah Eddin), Karimi, S. A. (Seyed Asaad), Kassebaum, N. J. (Nicholas J.), Katikireddi, S. V. (Srinivasa Vittal), Kawakami, N. (Norito), Kayode, G. A. (Gbenga A.), Keiyoro, P. N. (Peter Njenga), Keller, C. (Cathleen), Khader, Y. S. (Yousef Saleh), Khalid, N. (Nauman), Khan, E. A. (Ejaz Ahmad), Khan, M. (Maseer), Khang, Y.-H. (Young-Ho), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khazaei, S. (Salman), Khazaie, H. (Habibolah), Khodayari, M. T. (Mohammad Taghi), Khubchandani, J. (Jagdish), Kianipour, N. (Neda), Kim, C.-i. (Cho-il), Kim, Y.-E. (Young-Eun), Kim, Y. J. (Yun Jin), Kinfu, Y. (Yohannes), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissimova-Skarbek, K. (Katarzyna), Kivimaki, M. (Mika), Komaki, H. (Hamidreza), Kopec, J. A. (Jacek A.), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kravchenko, M. A. (Michael A.), Krishan, K. (Kewal), Krohn, K. J. (Kris J.), Defo, B. K. (Barthelemy Kuate), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kumar, V. (Vivek), Kusuma, D. (Dian), Kyu, H. H. (Hmwe Hmwe), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, D. K. (Dharmesh Kumar), Lalloo, R. (Ratilal), Lami, F. H. (Faris Hasan), Lansky, S. (Sonia), Larson, S. L. (Samantha Leigh), Larsson, A. O. (Anders O.), Lasrado, S. (Savita), Lassi, Z. S. (Zohra S.), Lazarus, J. V. (Jeffrey V.), Lee, P. H. (Paul H.), Lee, S. W. (Shaun Wen Huey), Leever, A. T. (Andrew T.), LeGrand, K. E. (Kate E.), Leonardi, M. (Matilde), Li, S. (Shanshan), Lim, L.-L. (Lee-Ling), Lim, S. S. (Stephen S.), Linn, S. (Shai), Lodha, R. (Rakesh), Logroscino, G. (Giancarlo), Lopez, A. D. (Alan D.), Lopukhov, P. D. (Platon D.), Lotufo, P. A. (Paulo A.), Lozano, R. (Rafael), Lu, A. (Alton), Lunevicius, R. (Raimundas), Madadin, M. (Mohammed), Maddison, E. R. (Emilie R.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Mahasha, P. W. (Phetole Walter), Mahdavi, M. M. (Mokhtar Mahdavi), Malekzadeh, R. (Reza), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansour-Ghanaei, F. (Fariborz), Mansouri, B. (Borhan), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Mastrogiacomo, C. I. (Claudia I.), Mathur, M. R. (Manu Raj), May, E. A. (Erin A.), McAlinden, C. (Colm), McGrath, J. J. (John J.), McKee, M. (Martin), Mehndiratta, M. M. (Man Mohan), Mehri, F. (Fereshteh), Mehta, K. M. (Kala M.), Meitei, W. B. (Wahengbam Bigyananda), Memiah, P. T. (Peter T. N.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mengesha, E. W. (Endalkachew Worku), Mensah, G. A. (George A.), Meretoja, A. (Atte), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Michalek, I. M. (Irmina Maria), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mills, E. J. (Edward J.), Milne, G. J. (George J.), Mirrakhimov, E. M. (Erkin M.), Mirzaei, H. (Hamed), Mirzaei, M. (Maryam), Mirzaei-Alavijeh, M. (Mehdi), Misganaw, A. T. (Awoke Temesgen), Moazen, B. (Babak), Moghadaszadeh, M. (Masoud), Mohamadi, E. (Efat), Mohammad, D. K. (Dara K.), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadbeigi, A. (Abolfazl), Mohammadian-Hafshejani, A. (Abdollah), Mohammadpourhodki, R. (Reza), Mohammed, H. (Hussen), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Bandpei, M. A. (Mohammad A. Mohseni), Mokari, A. (Amin), Mokdad, A. H. (Ali H.), Momen, N. C. (Natalie C.), Monasta, L. (Lorenzo), Mooney, M. D. (Meghan D.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moradzadeh, R. (Rahmatollah), Moraga, P. (Paula), Velasquez, I. M. (Ilais Moreno), Morgado-da-Costa, J. (Joana), Morrison, S. D. (Shane Douglas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Khaneghah, A. M. (Amin Mousavi), Mueller, U. O. (Ulrich Otto), Musa, K. I. (Kamarul Imran), Muthupandian, S. (Saravanan), Nabavizadeh, B. (Behnam), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naghshtabrizi, B. (Behshad), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Negoi, R. I. (Ruxandra Irina), Ngunjiri, J. W. (Josephine W.), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, Y. T. (Yeshambel T.), Nikbakhsh, R. (Rajan), Nikpoor, A. R. (Amin Reza), Nixon, M. R. (Molly R.), Nnaji, C. A. (Chukwudi A.), Nomura, S. (Shuhei), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Nowak, C. (Christoph), Otoiu, A. (Adrian), Odell, C. M. (Christopher M.), Oh, I.-H. (In-Hwan), Oladnabi, M. (Morteza), Olagunju, A. T. (Andrew T.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Bali, A. O. (Ahmed Omar), Ong, K. L. (Kanyin L.), Onwujekwe, O. E. (Obinna E.), Ortiz, A. (Alberto), Otstavnov, N. (Nikita), Otstavnov, S. S. (Stanislav S.), Overland, S. (Simon), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakshir, K. (Keyvan), Palladino, R. (Raffaele), Pana, A. (Adrian), Panda-Jonas, S. (Songhomitra), Park, J. (James), Pasupula, D. K. (Deepak Kumar), Patel, J. R. (Jenil R.), Patel, S. K. (Sangram Kishor), Patton, G. C. (George C.), Paulson, K. R. (Katherine R.), Toroudi, H. P. (Hamidreza Pazoki), Pease, S. A. (Spencer A.), Peden, A. E. (Amy E.), Pepito, V. C. (Veincent Christian Filipino), Peprah, E. K. (Emmanuel K.), Pereira, A. (Alexandre), Pereira, D. M. (David M.), Perico, N. (Norberto), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pilz, T. M. (Tessa M.), Piradov, M. A. (Michael A.), Pirsaheb, M. (Meghdad), Pokhrel, K. N. (Khem Narayan), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poznanska, A. (Anna), Prada, S. I. (Sergio I.), Prakash, S. (Sanjay), Preotescu, L. (Liliana), Syed, Z. Q. (Zahiruddin Quazi), Rabiee, M. (Mohammad), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Raggi, A. (Alberto), Rahman, M. A. (Muhammad Aziz), Rajabpour-Sanati, A. (Ali), Ram, P. (Pradhum), Ranabhat, C. L. (Chhabi Lal), Rao, S. J. (Sowmya J.), Rasella, D. (Davide), Rashedi, V. (Vahid), Rastogi, P. (Prateek), Rathi, P. (Priya), Rawal, L. (Lal), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Rezaei, N. (Nima), Rezai, M. s. (Mohammad sadegh), Rezapour, A. (Aziz), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Roshandel, G. (Gholamreza), Rostamian, M. (Morteza), Rubagotti, E. (Enrico), Rwegerera, G. M. (Godfrey M.), Sabour, S. (Siamak), Saddik, B. (Basema), Sadeghi, E. (Ehsan), Sadeghi, M. (Masoumeh), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Safi, S. (Sare), Safiri, S. (Saeid), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salama, J. S. (Joseph S.), Salamati, P. (Payman), Salem, M. R. (Marwa R. Rashad), Salimi, Y. (Yahya), Salomon, J. A. (Joshua A.), Salz, I. (Inbal), Samad, Z. (Zainab), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sartorius, B. (Benn), Sarveazad, A. (Arash), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sattin, D. (Davide), Saylan, M. (Mete), Schaeffer, L. E. (Lauren E.), Schiavolin, S. (Silvia), Schwebel, D. C. (David C.), Schwendicke, F. (Falk), Sekerija, M. (Mario), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabani, M. (Mahsima), Shahabi, S. (Saeed), Shahbaz, M. (Mohammad), Shaheen, A. A. (Amira A.), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharafi, Z. (Zeinab), Sharara, F. (Fablina), Sharma, R. (Rajesh), Shaw, D. H. (David H.), Sheikh, A. (Aziz), Il Shin, J. (Jae), Shiri, R. (Rahman), Shrime, M. G. (Mark G.), Shuval, K. (Kerem), Siabani, S. (Soraya), Sigfusdottir, I. D. (Inga Dora), Sigurvinsdottir, R. (Rannveig), Silva, D. A. (Diego Augusto Santos), Simonetti, B. (Biagio), Simpson, K. E. (Kyle E.), Singh, J. A. (Jasvinder A.), Skiadaresi, E. (Eirini), Skryabin, V. Y. (Valentin Yurievich), Soheili, A. (Amin), Sokhan, A. (Anton), Sorensen, R. J. (Reed J. D.), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Stockfelt, L. (Leo), Stokes, M. A. (Mark A.), Stubbs, J. L. (Jacob L.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Abdulkader, R. S. (Rizwan Suliankatchi), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabb, K. M. (Karen M.), Tadakamadla, S. K. (Santosh Kumar), Taherkhani, A. (Amir), Tang, M. (Muming), Taveira, N. (Nuno), Taylor, H. J. (Heather Jean), Teagle, W. L. (Whitney L.), Tehrani-Banihashemi, A. (Arash), Teklehaimanot, B. F. (Berhane Fseha), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Thrift, A. G. (Amanda G.), Titova, M. V. (Mariya Vladimirovna), Tohidinik, H. R. (Hamid Reza), Tonelli, M. (Marcello), Topor-Madry, R. (Roman), Topouzis, F. (Fotis), Tovani-Palone, M. R. (Marcos Roberto Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Travillian, R. (Ravensara), Trias-Llimos, S. (Sergi), Truelsen, T. C. (Thomas Clement), Car, L. T. (Lorainne Tudor), Unnikrishnan, B. (Bhaskaran), Upadhyay, E. (Era), Vacante, M. (Marco), Vakilian, A. (Alireza), Valdez, P. R. (Pascual R.), Valli, A. (Alessandro), Vardavas, C. (Constantine), Vasankari, T. J. (Tommi Juhani), Vasconcelos, A. M. (Ana Maria Nogales), Vasseghian, Y. (Yasser), Veisani, Y. (Yousef), Venketasubramanian, N. (Narayanaswamy), Vidale, S. (Simone), Violante, F. S. (Francesco S.), Vlassov, V. (Vasily), Vollset, S. E. (Stein Emil), Vos, T. (Theo), Vujcic, I. S. (Isidora S.), Vukovic, A. (Ana), Vukovic, R. (Rade), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Walters, M. K. (Magdalene K.), Wang, H. (Hongbo), Wang, Y.-P. (Yuan-Pang), Watson, S. (Stefanie), Wei, J. (Jingkai), Weiss, J. (Jordan), Weldesamuel, G. T. (Girmay Teklay), Werdecker, A. (Andrea), Westerman, R. (Ronny), Whiteford, H. A. (Harvey A.), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wojtyniak, B. (Bogdan), Wolfe, C. D. (Charles D. A.), Wondmieneh, A. B. (Adam Belay), Wool, E. E. (Eve E.), Wu, A.-M. (Ai-Min), Wu, J. (Junjie), Xu, G. (Gelin), Yamada, T. (Tomohide), Yamagishi, K. (Kazumasa), Yano, Y. (Yuichiro), Yaya, S. (Sanni), Yazdi-Feyzabadi, V. (Vahid), Yearwood, J. A. (Jamal A.), Yeheyis, T. Y. (Tomas Y.), Yilgwan, C. S. (Christopher Sabo), Yip, P. (Paul), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Lebni, J. Y. (Javad Yoosefi), York, H. W. (Hunter W.), Younis, M. Z. (Mustafa Z.), Younker, T. P. (Theodore Patrick), Yousefi, Z. (Zabihollah), Yousefinezhadi, T. (Taraneh), Yousuf, A. Y. (Abdilahi Yousuf), Yusefzadeh, H. (Hasan), Moghadam, T. Z. (Telma Zahirian), Zakzuk, J. (Josefina), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zamanian, M. (Maryam), Zandian, H. (Hamed), Zhang, Z.-J. (Zhi-Jiang), Zheng, P. (Peng), Zhou, M. (Maigeng), Ziapour, A. (Arash), and Murray, C. J. (Christopher J. L.)

Abstract

Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated us

Published
2020

194. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17

Author

Wiens, K. E. (Kirsten E.), Lindstedt, P. A. (Paulina A.), Blacker, B. F. (Brigette F.), Johnson, K. B. (Kimberly B.), Baumann, M. M. (Mathew M.), Schaeffer, L. E. (Lauren E.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Acharya, D. (Dilaram), Adabi, M. (Maryam), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhena, B. M. (Beyene Meressa), Afarideh, M. (Mohsen), Ahmad, S. (Sohail), Ahmadi, K. (Keivan), Ahmed, A. E. (Anwar E.), Ahmed, M. B. (Muktar Beshir), Ahmed, R. (Rushdia), Akalu, T. Y. (Temesgen Yihunie), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, N. (Noore), Alam, S. (Samiah), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, B. A. (Beriwan Abdulqadir), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Anoushiravani, A. (Amir), Ansari, F. (Fereshteh), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Atalay, H. T. (Hagos Tasew), Athari, S. S. (Seyyed Shamsadin), Athari, S. M. (Seyyede Masoume), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azzopardi, P. S. (Peter S.), Babaee, E. (Ebrahim), Babalola, T. K. (Tesleem Kayode), Badawi, A. (Alaa), Bairwa, M. (Mohan), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Bali, A. G. (Ayele Geleto), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barnighausen, T. W. (Till Winfried), Basaleem, H. (Huda), Basu, S. (Sanjay), Bay, V. D. (Vo Dinh), Bayati, M. (Mohsen), Baye, E. (Estifanos), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Masoud), Behzadifar, M. (Meysam), Bekele, B. B. (Bayu Begashaw), Belayneh, Y. M. (Yaschilal Muche), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhattarai, S. (Suraj), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Birihane, B. M. (Binyam Minuye), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Bojia, H. A. (Hunduma Amensisa), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Bragazzi, N. L. (Nicola Luigi), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Nagaraja, S. B. (Sharath Burugina), Busse, R. (Reinhard), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Chanie, W. F. (Wagaye Fentahun), Chatterjee, P. (Pranab), Chattu, V. K. (Vijay Kumar), Chichiabellu, T. Y. (Tesfaye Yitna), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Culquichicon, C. (Carlos), Daba, M. S. (Matiwos Soboka), Damiani, G. (Giovanni), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dang, A. K. (Anh Kim), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davey, G. (Gail), Davila-Cervantes, C. A. (Claudio Alberto), Davis, A. C. (Adrian C.), Davitoiu, D. V. (Dragos Virgil), De la Hoz, F. P. (Fernando Pio), Demis, A. B. (Asmamaw Bizuneh), Demissie, D. B. (Dereje Bayissa), Demissie, G. D. (Getu Debalkie), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Deshpande, A. (Aniruddha), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Djalalinia, S. (Shirin), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duko, B. (Bereket), Duraes, A. R. (Andre Rodrigues), Kalan, M. E. (Mohammad Ebrahimi), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), El Sayed, I. (Iman), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elema, T. B. (Teshome Bekele), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa I.), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Elyazar, I. R. (Iqbal R. F.), Endalamaw, A. (Aklilu), Endalew, D. A. (Daniel Adane), Eskandarieh, S. (Sharareh), Esteghamati, A. (Alireza), Esteghamati, S. (Sadaf), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Farzadfar, F. (Farshad), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Gayesa, R. T. (Reta Tsegaye), Gebre, T. (Teshome), Gebremedhin, K. B. (Ketema Bizuwork), Gebremeskel, G. G. (Gebreamlak Gebremedhn), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghadiri, K. (Keyghobad), Ghashghaee, A. (Ahmad), Ghimire, P. R. (Pramesh Raj), Gill, P. S. (Paramjit Singh), Gill, T. K. (Tiffany K.), Ginindza, T. G. (Themba G.), Gomes, N. G. (Nelson G. M.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Goulart, B. N. (Barbara Niegia Garcia), Grada, A. (Ayman), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Hailu, G. B. (Gessessew Bugssa), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Hamadeh, R. R. (Randah R.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed I.), Hasan, M. M. (Md Mehedi), Hasanpoor, E. (Edris), Hasanzadeh, A. (Amir), Hassankhani, H. (Hadi), Hassen, H. Y. (Hamid Yimam), Hegazy, M. I. (Mohamed I.), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hoang, C. L. (Chi Linh), Rad, E. H. (Enayatollah Homaie), Hoogar, P. (Praveen), Hoseini, M. (Mohammad), Hossain, N. (Naznin), Hosseini, M. (Mostafa), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hsairi, M. (Mohamed), Hu, G. (Guoqing), Hussen, M. M. (Mohammedaman Mama), Ibitoye, S. E. (Segun Emmanuel), Igumbor, E. U. (Ehimario U.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Iwu, C. J. (Chinwe Juliana), Izadi, N. (Neda), Jaca, A. (Anelisa), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kahsay, A. (Amaha), Kalani, H. (Hamed), Kanchan, T. (Tanuj), Matin, B. K. (Behzad Karami), Karch, A. (Andre), Karim, M. A. (Mohd Anisul), Karki, H. K. (Hamidreza Karimi-Sari Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasahun, Y. C. (Yawukal Chane), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Karyani, A. K. (Ali Kazemi), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Kelbore, A. G. (Abraham Getachew), Kengne, A. P. (Andre Pascal), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, M. N. (Md Nuruzzaman), Khan, M. S. (Muhammad Shahzeb), Khatab, K. (Khaled), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khazaei, S. (Salman), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissoon, N. (Niranjan), Shivakumar, K. M. (K. M.), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kraemer, M. U. (Moritz U. G.), Krishan, K. (Kewal), Kugbey, N. (Nuworza), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kusuma, V. K. (Vivek Kumar Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lad, S. D. (Sheetal D.), Lal, D. K. (Dharmesh Kumar), Lam, F. (Felix), Lami, F. H. (Faris Hasan), Lamichhane, P. (Prabhat), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Laxmaiah, A. (Avula), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Liu, S. (Simin), Lodha, R. (Rakesh), Longbottom, J. (Joshua), Lopez, J. C. (Jaifred Christian F.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Manda, A. L. (Ana Laura), Manohar, N. D. (Narendar Dawani Dawanu), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Maravilla, J. C. (Joemer C.), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Massenburg, B. B. (Benjamin Ballard), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Mehta, K. M. (Kala M.), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Miazgowski, B. (Bartosz), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohamadi-Bolbanabad, A. (Amjad), Mohammad, D. K. (Dara K.), Mohammad, K. A. (Karzan Abdulmuhsin), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammadifard, N. (Noushin), Mohammed, J. A. (Jemal Abdu), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Molokhia, M. (Mariam), Monasta, L. (Lorenzo), Moodley, Y. (Yoshan), Moore, C. E. (Catrin E.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moraga, P. (Paula), Morales, L. (Linda), Velasquez, I. M. (Ilais Moreno), Mosapour, A. (Abbas), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Muchie, K. F. (Kindie Fentahun), Mulaw, G. F. (Getahun Fentaw), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christoper J. L.), Murthy, G. V. (G. V. S.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Nabhan, A. F. (Ashraf F.), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naidoo, K. S. (Kovin S.), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, C. T. (Cuong Tat), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, D. (Dabere), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Nong, V. M. (Vuong Minh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Oancea, B. (Bogdan), Ogah, O. S. (Okechukwu Samuel), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olagunju, T. O. (Tinuke O.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Onwujekwe, O. E. (Obinna E.), Oren, E. (Eyal), Ortega-Altamirano, D. V. (Doris V.), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Patel, S. K. (Sangram Kishor), Paternina-Caicedo, A. J. (Angel J.), Pathak, A. (Ashish), Patton, G. C. (George C.), Paudel, D. (Deepak), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Pereira, A. (Alexandre), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Piroozi, B. (Bakhtiar), Pirsaheb, M. (Meghdad), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poustchi, H. (Hossein), Prada, S. I. (Sergio I.), Prasad, N. (Narayan), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi-Movaghar, A. (Afarin), Rahimi-Movaghar, V. (Vafa), Rahman, M. H. (Mohammad Hifz Ur), Rahman, M. A. (Muhammad Aziz), Rahman, S. (Shafiur), Rajati, F. (Fatemeh), Rana, S. M. (Saleem Muhammad), Ranabhat, C. L. (Chhabi Lal), Rasella, D. (Davide), Rawaf, D. L. (David Laith), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Reta, M. A. (Melese Abate), Rezaei, N. (Negar), Rezai, M. S. (Mohammad Sadegh), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Rios-Blancas, M. (Maria), Roever, L. (Leonardo), Ronfani, L. (Luca), Roro, E. M. (Elias Merdassa), Ross, J. M. (Jennifer M.), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabde, Y. D. (Yogesh Damodar), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Safari, Y. (Yahya), Safari-Faramani, R. (Roya), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Salamati, P. (Payman), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Jose, B. P. (Bruno Piassi Sao), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarkar, K. (Kaushik), Sarker, A. R. (Abdur Razzaque), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sawhney, M. (Monika), Saxena, S. (Sonia), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabaninejad, H. (Hosein), Shafieesabet, A. (Azadeh), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shallo, S. A. (Seifadin Ahmed), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharifi, H. (Hamid), Shehata, H. S. (Hatem Samir), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shibuya, K. (Kenji), Shiferaw, W. S. (Wondimeneh Shibabaw), Shifti, D. M. (Desalegn Markos), Shigematsu, M. (Mika), Il Shin, J. (Jae), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, A. (Ambrish), Singh, J. A. (Jasvinder A.), Singh, N. P. (Narinder Pal), Singh, V. (Virendra), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soltani, S. (Shahin), Somayaji, R. (Ranjani), Soofi, M. (Moslem), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sultana, M. (Marufa), Sunguya, B. F. (Bruno Fokas), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Tasew, A. A. (Aberash Abay), Tefera, Y. M. (Yonatal Mesfin), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, B. (Belay), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Toma, A. (Alemayehu), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Tran, K. B. (Khanh Bao), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Hawariat, F. G. (Feleke Gebremeskel W.), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y. (Yafeng), Wang, Y.-P. (Yuan-Pang), Weaver, M. (Marcia), Weji, B. G. (Bedilu Girma), Weldesamuel, G. T. (Girmay Teklay), Welgan, C. A. (Catherine A.), Werdecker, A. (Andrea), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Wu, A.-M. (Ai-Min), Xu, G. (Gelin), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilgwan, C. S. (Christopher Sabo), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. Z. (Mustafa Z.), Yousefifard, M. (Mahmoud), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zepro, N. B. (Nejimu Biza), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Zhao, X. G. (Xiu-Ju George), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon I.), Reiner, R. C. (Robert C., Jr.), Wiens, K. E. (Kirsten E.), Lindstedt, P. A. (Paulina A.), Blacker, B. F. (Brigette F.), Johnson, K. B. (Kimberly B.), Baumann, M. M. (Mathew M.), Schaeffer, L. E. (Lauren E.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Acharya, D. (Dilaram), Adabi, M. (Maryam), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhena, B. M. (Beyene Meressa), Afarideh, M. (Mohsen), Ahmad, S. (Sohail), Ahmadi, K. (Keivan), Ahmed, A. E. (Anwar E.), Ahmed, M. B. (Muktar Beshir), Ahmed, R. (Rushdia), Akalu, T. Y. (Temesgen Yihunie), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, N. (Noore), Alam, S. (Samiah), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Ali, B. A. (Beriwan Abdulqadir), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Anoushiravani, A. (Amir), Ansari, F. (Fereshteh), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Atalay, H. T. (Hagos Tasew), Athari, S. S. (Seyyed Shamsadin), Athari, S. M. (Seyyede Masoume), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azzopardi, P. S. (Peter S.), Babaee, E. (Ebrahim), Babalola, T. K. (Tesleem Kayode), Badawi, A. (Alaa), Bairwa, M. (Mohan), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Bali, A. G. (Ayele Geleto), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barnighausen, T. W. (Till Winfried), Basaleem, H. (Huda), Basu, S. (Sanjay), Bay, V. D. (Vo Dinh), Bayati, M. (Mohsen), Baye, E. (Estifanos), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Masoud), Behzadifar, M. (Meysam), Bekele, B. B. (Bayu Begashaw), Belayneh, Y. M. (Yaschilal Muche), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhattarai, S. (Suraj), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Birihane, B. M. (Binyam Minuye), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Bojia, H. A. (Hunduma Amensisa), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Bragazzi, N. L. (Nicola Luigi), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Nagaraja, S. B. (Sharath Burugina), Busse, R. (Reinhard), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Chanie, W. F. (Wagaye Fentahun), Chatterjee, P. (Pranab), Chattu, V. K. (Vijay Kumar), Chichiabellu, T. Y. (Tesfaye Yitna), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Culquichicon, C. (Carlos), Daba, M. S. (Matiwos Soboka), Damiani, G. (Giovanni), Dandona, L. (Lalit), Dandona, R. (Rakhi), Dang, A. K. (Anh Kim), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davey, G. (Gail), Davila-Cervantes, C. A. (Claudio Alberto), Davis, A. C. (Adrian C.), Davitoiu, D. V. (Dragos Virgil), De la Hoz, F. P. (Fernando Pio), Demis, A. B. (Asmamaw Bizuneh), Demissie, D. B. (Dereje Bayissa), Demissie, G. D. (Getu Debalkie), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Deshpande, A. (Aniruddha), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Djalalinia, S. (Shirin), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duko, B. (Bereket), Duraes, A. R. (Andre Rodrigues), Kalan, M. E. (Mohammad Ebrahimi), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), El Sayed, I. (Iman), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elema, T. B. (Teshome Bekele), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa I.), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Elyazar, I. R. (Iqbal R. F.), Endalamaw, A. (Aklilu), Endalew, D. A. (Daniel Adane), Eskandarieh, S. (Sharareh), Esteghamati, A. (Alireza), Esteghamati, S. (Sadaf), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Fareed, M. (Mohammad), Faridnia, R. (Roghiyeh), Farzadfar, F. (Farshad), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Gayesa, R. T. (Reta Tsegaye), Gebre, T. (Teshome), Gebremedhin, K. B. (Ketema Bizuwork), Gebremeskel, G. G. (Gebreamlak Gebremedhn), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghadiri, K. (Keyghobad), Ghashghaee, A. (Ahmad), Ghimire, P. R. (Pramesh Raj), Gill, P. S. (Paramjit Singh), Gill, T. K. (Tiffany K.), Ginindza, T. G. (Themba G.), Gomes, N. G. (Nelson G. M.), Gopalani, S. V. (Sameer Vali), Goulart, A. C. (Alessandra C.), Goulart, B. N. (Barbara Niegia Garcia), Grada, A. (Ayman), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Hailu, G. B. (Gessessew Bugssa), Haj-Mirzaian, A. (Arvin), Haj-Mirzaian, A. (Arya), Hamadeh, R. R. (Randah R.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed I.), Hasan, M. M. (Md Mehedi), Hasanpoor, E. (Edris), Hasanzadeh, A. (Amir), Hassankhani, H. (Hadi), Hassen, H. Y. (Hamid Yimam), Hegazy, M. I. (Mohamed I.), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henry, N. J. (Nathaniel J.), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hoang, C. L. (Chi Linh), Rad, E. H. (Enayatollah Homaie), Hoogar, P. (Praveen), Hoseini, M. (Mohammad), Hossain, N. (Naznin), Hosseini, M. (Mostafa), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hsairi, M. (Mohamed), Hu, G. (Guoqing), Hussen, M. M. (Mohammedaman Mama), Ibitoye, S. E. (Segun Emmanuel), Igumbor, E. U. (Ehimario U.), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Iwu, C. J. (Chinwe Juliana), Izadi, N. (Neda), Jaca, A. (Anelisa), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kahsay, A. (Amaha), Kalani, H. (Hamed), Kanchan, T. (Tanuj), Matin, B. K. (Behzad Karami), Karch, A. (Andre), Karim, M. A. (Mohd Anisul), Karki, H. K. (Hamidreza Karimi-Sari Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasahun, Y. C. (Yawukal Chane), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Karyani, A. K. (Ali Kazemi), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Kelbore, A. G. (Abraham Getachew), Kengne, A. P. (Andre Pascal), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, M. N. (Md Nuruzzaman), Khan, M. S. (Muhammad Shahzeb), Khatab, K. (Khaled), Khater, A. M. (Amir M.), Khater, M. M. (Mona M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khazaei, S. (Salman), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, A. (Adnan), Kisa, S. (Sezer), Kissoon, N. (Niranjan), Shivakumar, K. M. (K. M.), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Kraemer, M. U. (Moritz U. G.), Krishan, K. (Kewal), Kugbey, N. (Nuworza), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kumar, P. (Pushpendra), Kusuma, V. K. (Vivek Kumar Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lad, S. D. (Sheetal D.), Lal, D. K. (Dharmesh Kumar), Lam, F. (Felix), Lami, F. H. (Faris Hasan), Lamichhane, P. (Prabhat), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Laxmaiah, A. (Avula), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Liu, S. (Simin), Lodha, R. (Rakesh), Longbottom, J. (Joshua), Lopez, J. C. (Jaifred Christian F.), Abd El Razek, H. M. (Hassan Magdy), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Manda, A. L. (Ana Laura), Manohar, N. D. (Narendar Dawani Dawanu), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Maravilla, J. C. (Joemer C.), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Masaka, A. (Anthony), Massenburg, B. B. (Benjamin Ballard), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Mehta, K. M. (Kala M.), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Miazgowski, B. (Bartosz), Mihretie, K. M. (Kebadnew Mulatu), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohamadi-Bolbanabad, A. (Amjad), Mohammad, D. K. (Dara K.), Mohammad, K. A. (Karzan Abdulmuhsin), Mohammad, Y. (Yousef), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammadifard, N. (Noushin), Mohammed, J. A. (Jemal Abdu), Mohammed, S. (Shafiu), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Molokhia, M. (Mariam), Monasta, L. (Lorenzo), Moodley, Y. (Yoshan), Moore, C. E. (Catrin E.), Moradi, G. (Ghobad), Moradi, M. (Masoud), Moradi-Joo, M. (Mohammad), Moradi-Lakeh, M. (Maziar), Moraga, P. (Paula), Morales, L. (Linda), Velasquez, I. M. (Ilais Moreno), Mosapour, A. (Abbas), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Muchie, K. F. (Kindie Fentahun), Mulaw, G. F. (Getahun Fentaw), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christoper J. L.), Murthy, G. V. (G. V. S.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Nabhan, A. F. (Ashraf F.), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naidoo, K. S. (Kovin S.), Naik, G. (Gurudatta), Najafi, F. (Farid), Nangia, V. (Vinay), Nansseu, J. R. (Jobert Richie), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, C. T. (Cuong Tat), Nguyen, H. L. (Huong Lan Thi), Nguyen, T. H. (Trang Huyen), Nigatu, D. (Dabere), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Nong, V. M. (Vuong Minh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Motlagh, S. N. (Soraya Nouraei), Oancea, B. (Bogdan), Ogah, O. S. (Okechukwu Samuel), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olagunju, T. O. (Tinuke O.), Olusanya, B. O. (Bolajoko Olubukunola), Olusanya, J. O. (Jacob Olusegun), Onwujekwe, O. E. (Obinna E.), Oren, E. (Eyal), Ortega-Altamirano, D. V. (Doris V.), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Patel, S. K. (Sangram Kishor), Paternina-Caicedo, A. J. (Angel J.), Pathak, A. (Ashish), Patton, G. C. (George C.), Paudel, D. (Deepak), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Pereira, A. (Alexandre), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Piroozi, B. (Bakhtiar), Pirsaheb, M. (Meghdad), Postma, M. J. (Maarten J.), Pourjafar, H. (Hadi), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Poustchi, H. (Hossein), Prada, S. I. (Sergio I.), Prasad, N. (Narayan), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi-Movaghar, A. (Afarin), Rahimi-Movaghar, V. (Vafa), Rahman, M. H. (Mohammad Hifz Ur), Rahman, M. A. (Muhammad Aziz), Rahman, S. (Shafiur), Rajati, F. (Fatemeh), Rana, S. M. (Saleem Muhammad), Ranabhat, C. L. (Chhabi Lal), Rasella, D. (Davide), Rawaf, D. L. (David Laith), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Reta, M. A. (Melese Abate), Rezaei, N. (Negar), Rezai, M. S. (Mohammad Sadegh), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Rios-Blancas, M. (Maria), Roever, L. (Leonardo), Ronfani, L. (Luca), Roro, E. M. (Elias Merdassa), Ross, J. M. (Jennifer M.), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabde, Y. D. (Yogesh Damodar), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Safari, Y. (Yahya), Safari-Faramani, R. (Roya), Sagar, R. (Rajesh), Sahebkar, A. (Amirhossein), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Salamati, P. (Payman), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santric-Milicevic, M. M. (Milena M.), Jose, B. P. (Bruno Piassi Sao), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarkar, K. (Kaushik), Sarker, A. R. (Abdur Razzaque), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Sawhney, M. (Monika), Saxena, S. (Sonia), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shabaninejad, H. (Hosein), Shafieesabet, A. (Azadeh), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shallo, S. A. (Seifadin Ahmed), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharifi, H. (Hamid), Shehata, H. S. (Hatem Samir), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shibuya, K. (Kenji), Shiferaw, W. S. (Wondimeneh Shibabaw), Shifti, D. M. (Desalegn Markos), Shigematsu, M. (Mika), Il Shin, J. (Jae), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, A. (Ambrish), Singh, J. A. (Jasvinder A.), Singh, N. P. (Narinder Pal), Singh, V. (Virendra), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soltani, S. (Shahin), Somayaji, R. (Ranjani), Soofi, M. (Moslem), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sultana, M. (Marufa), Sunguya, B. F. (Bruno Fokas), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Tasew, A. A. (Aberash Abay), Tefera, Y. M. (Yonatal Mesfin), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, B. (Belay), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), Thomas, N. (Nihal), Toma, A. (Alemayehu), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Tran, B. X. (Bach Xuan), Tran, K. B. (Khanh Bao), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Hawariat, F. G. (Feleke Gebremeskel W.), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y. (Yafeng), Wang, Y.-P. (Yuan-Pang), Weaver, M. (Marcia), Weji, B. G. (Bedilu Girma), Weldesamuel, G. T. (Girmay Teklay), Welgan, C. A. (Catherine A.), Werdecker, A. (Andrea), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Wu, A.-M. (Ai-Min), Xu, G. (Gelin), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilgwan, C. S. (Christopher Sabo), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. Z. (Mustafa Z.), Yousefifard, M. (Mahmoud), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zepro, N. B. (Nejimu Biza), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Zhao, X. G. (Xiu-Ju George), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon I.), and Reiner, R. C. (Robert C., Jr.)

Abstract

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Methods: We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000–17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2·5th and 97·5th percentiles of those 250 draws. Findings: While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62·6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000–7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall O

Published
2020

195. BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

Author

Huihui Ye, Xin Yuan, Changmeng Cai, Sen Chen, Steven P. Balk, Nathanael S. Gray, Adam G. Sowalsky, Nicholas I. Simon, and Fen Ma

Subjects
Male, 0301 basic medicine, Cancer Research, Amino Acid Motifs, Mice, SCID, Biology, urologic and male genital diseases, Antibodies, Gene Expression Regulation, Enzymologic, Article, Receptor tyrosine kinase, Mice, 03 medical and health sciences, Piperidines, Cell Line, Tumor, Animals, Humans, Bruton's tyrosine kinase, Phosphorylation, Kinase activity, Mice, Inbred ICR, Sequence Analysis, RNA, Kinase, Adenine, Androgen Antagonists, Protein-Tyrosine Kinases, Gene Expression Regulation, Neoplastic, Androgen receptor, Prostatic Neoplasms, Castration-Resistant, HEK293 Cells, Pyrimidines, 030104 developmental biology, Oncology, Receptors, Androgen, Tissue Array Analysis, Androgens, biology.protein, Cancer research, Pyrazoles, Signal transduction, Tyrosine kinase, Neoplasm Transplantation, Protein Binding, Signal Transduction
Abstract

Prostate cancer responds to therapies that suppress androgen receptor (AR) activity (androgen deprivation therapy, ADT) but invariably progresses to castration-resistant prostate cancer (CRPC). The Tec family nonreceptor tyrosine kinase BMX is activated downstream of PI3K and has been implicated in regulation of multiple pathways and in the development of cancers including prostate cancer. However, its precise mechanisms of action, and particularly its endogenous substrates, remain to be established. Here, we demonstrate that BMX expression in prostate cancer is suppressed directly by AR via binding to the BMX gene and that BMX expression is subsequently rapidly increased in response to ADT. BMX contributed to CRPC development in cell line and xenograft models by positively regulating the activities of multiple receptor tyrosine kinases through phosphorylation of a phosphotyrosine-tyrosine (pYY) motif in their activation loop, generating pYpY that is required for full kinase activity. To assess BMX activity in vivo, we generated a BMX substrate–specific antibody (anti-pYpY) and found that its reactivity correlated with BMX expression in clinical samples, supporting pYY as an in vivo substrate. Inhibition of BMX with ibrutinib (developed as an inhibitor of the related Tec kinase BTK) or another BMX inhibitor BMX-IN-1 markedly enhanced the response to castration in a prostate cancer xenograft model. These data indicate that increased BMX in response to ADT contributes to enhanced tyrosine kinase signaling and the subsequent emergence of CRPC, and that combination therapies targeting AR and BMX may be effective in a subset of patients. Significance: The tyrosine kinase BMX is negatively regulated by androgen and contributes to castration-resistant prostate cancer by enhancing the phosphorylation and activation of multiple receptor tyrosine kinases following ADT. Cancer Res; 78(18); 5203–15. ©2018 AACR.

Published
2018
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196. Questioning the benefit of restrictive transfusion practice in older adults

Author

Ogilvie Thom, Alison Craswell, Yoke Lin Fung, and Geoff I Simon

Subjects
medicine.medical_specialty, business.industry, 030204 cardiovascular system & hematology, Asymptomatic, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Older patients, law, Younger adults, Cohort, medicine, General Earth and Planetary Sciences, Resource consumption, Risk factor, medicine.symptom, Intensive care medicine, business, Lower mortality, 030215 immunology, General Environmental Science
Abstract

Restrictive transfusion practice is widely promoted, with many international guidelines recommending haemoglobin thresholds of 70 to 80 g/l for adult patients who are asymptomatic. Randomized controlled trials comparing outcomes associated with liberal and restrictive transfusion strategies underpin this approach. Meta‐analyses including trials of adult patients >18 years of age have concluded that restrictive practice is noninferior to liberal transfusion approaches. A restrictive approach to transfusion reduces resource consumption and cost, as well as the hazards associated with unnecessary exposure to blood products. Although adults aged ≥65 years consume over half of the blood supply, there are few randomized controlled transfusion trials exclusive to this cohort. Our 2017 meta‐analysis of a small number of trials focussed on older adults found that higher transfusion haemoglobin thresholds were associated with lower mortality and fewer cardiac complications in this age group. Other studies have also shown that higher transfusion haemoglobin thresholds are beneficial in older adults. This paper presents recent evidence regarding transfusion outcomes in older adults and discusses aspects of the pathophysiology of ageing that impact on the reduced resilience of older patients to anaemic states. This evidence challenges the use of Hb thresholds that apply across the adult lifespan, regardless of age. It proposes that older age be considered as a risk factor in assessing transfusion requirements, and that transfusion practice in older adults may require higher haemoglobin thresholds than for younger adults.

Published
2018
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197. Particle size distributions in chondritic meteorites: Evidence for pre-planetesimal histories

Author

Jeffrey D. Scargle, P. Srinivasan, Daniel M. Olson, Justin I. Simon, Jeffrey N. Cuzzi, K. A. McCain, Kent R. Fisher, Michael J Cato, Alastair W. Tait, and Peter A Christoffersen

Subjects
education.field_of_study, Population, Chondrule, Astrophysics, 010502 geochemistry & geophysics, 01 natural sciences, Accretion (astrophysics), Geophysics, Allende meteorite, Meteorite, Space and Planetary Science, Geochemistry and Petrology, Chondrite, Carbonaceous chondrite, 0103 physical sciences, Earth and Planetary Sciences (miscellaneous), education, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences, Ordinary chondrite
Abstract

Magnesium-rich silicate chondrules and calcium-, aluminum-rich refractory inclusions (CAIs) are fundamental components of primitive chondritic meteorites. It has been suggested that concentration of these early-formed particles by nebular sorting processes may lead to accretion of planetesimals, the planetary bodies that represent the building blocks of the terrestrial planets. In this case, the size distributions of the particles may constrain the accretion process. Here we present new particle size distribution data for Northwest Africa 5717, a primitive ordinary chondrite (ungrouped 3.05) and the well-known carbonaceous chondrite Allende (CV3). Instead of the relatively narrow size distributions obtained in previous studies ( Ebel et al., 2016 , Friedrich et al., 2015 , Paque and Cuzzi, 1997 , and references therein), we observed broad size distributions for all particle types in both meteorites. Detailed microscopic image analysis of Allende shows differences in the size distributions of chondrule subtypes, but collectively these subpopulations comprise a composite “chondrule” size distribution that is similar to the broad size distribution found for CAIs. Also, we find accretionary ‘dust’ rims on only a subset (∼15–20%) of the chondrules contained in Allende, which indicates that subpopulations of chondrules experienced distinct histories prior to planetary accretion. For the rimmed subset, we find positive correlation between rim thickness and chondrule size. The remarkable similarity between the size distributions of various subgroups of particles, both with and without fine grained rims, implies a common size sorting process. Chondrite classification schemes, astrophysical disk models that predict a narrow chondrule size population and/or a common localized formation event, and conventional particle analysis methods must all be critically reevaluated. We support the idea that distinct “lithologies” in NWA 5717 are nebular aggregates of chondrules. If ≥cm-sized aggregates of chondrules can form it will have implications for planet formation and suggests the sticking stage is where the preferential size physics is operating.

Published
2018
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198. Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency

Author

Olivier Picone, Agnes Guet, Laurent Mandelbrot, Charles Egloff, Aurelia Eldin de Pecoulas, Chloé Dussaux, Audrey Boutron, I. Simon, Mikael Tassin, Frederic Corrizi, Valerie Mairovitz, Charlotte Mechler, and Jeanne Sibiude

Subjects
0301 basic medicine, Fetus, Pathology, medicine.medical_specialty, Pregnancy, Pyruvate carboxylase deficiency, business.industry, Obstetrics and Gynecology, Corpus callosum, medicine.disease, Pyruvate dehydrogenase complex, Pyruvate dehydrogenase deficiency, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine, Abnormality, business, 030217 neurology & neurosurgery, Genetics (clinical), Ventriculomegaly
Abstract

Objective Pyruvate dehydrogenase deficiency (PDHD) and pyruvate carboxylase deficiency (PCD) are diseases with severe neonatal forms, and their low prevalence makes them difficult to diagnose during pregnancy. Our objective was to describe prenatal ultrasound features that may be suggestive of these diagnoses. Methods We analyzed 3 cases from our institution and reviewed 12 published cases of PDHD and 6 cases of PCD, recording all of the ultrasound signs, as well as magnetic resonance findings when available. Because of the small number of cases of PCD, we also included postnatal signs that could have been observed during imaging during pregnancy, for a total of 11 cases of PCD. Results We conclude that PDHD can be suggested in the presence of ventriculomegaly or paraventricular cysts, associated with an abnormality of the cerebral parenchyma such as abnormal gyration or involvement of the corpus callosum. Pyruvate carboxylase deficiency can be suggested in the presence of ventriculomegaly, frontal horn impairment associated with subependymal, and paraventricular cysts. Conclusion When confronted to the ultrasound abnormalities we described, and after eliminating the most frequent etiologies, a metabolic deficiency should be considered. Furthermore, the hereditary character of these diseases makes that it is important to send the family with genetic advice in particular in case of history of a fetal death in utero or a death neonatal unexplained.

Published
2018
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199. Improving Fluoroscopic Visualization for Lower Cervical Medial Branch Blocks with a Modified Swimmer’s View: A Technical Report

Author

Jeremy I. Simon, George W. Young, David S Stolzenberg, Jeffrey Gehret, Ryan Pheifer, George C Chang-Chien, and Joshua Armstrong

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Shoulders, Radiography, Zygapophyseal Joint, Facet joint, Visualization, Anesthesiology and Pain Medicine, Physical medicine and rehabilitation, medicine.anatomical_structure, Private practice, medicine, Technical report, Fluoroscopy, business
Abstract

Background: Neural blockade of the cervical medial branches is a validated procedure in the diagnosis and treatment of cervical zygapophyseal joint pain. Fluoroscopic visualization of the lower cervical medial branch target zones (CMBTZs) in lateral view is sometimes challenging or not possible due to the patient’s shoulders obscuring the target. Large shoulders and short necks often exacerbate the problem. Clear visualization is critical to accuracy and safety. Objective: We aim to describe a method for optimal fluoroscopic visualization of the lower CMBTZs using a modified swimmer’s view. Study Design: A technical report. Setting: A private practice. Methods: Discussion with accompanying fluoroscopic images of the cervical spine, focusing on the lateral aspects of the lower cervical articular pillars in both the traditional lateral view and modified swimmer’s view. Four authors served as volunteers for undergoing fluoroscopic x-rays in both views. Visualization of each lower CMBTZ was attempted and stored. The most caudal, clearly visualized levels were compared in both views for each participant. Results: Visualization of the lower CMBTZs can be successfully obtained with the modified swimmer’s view and in select patients is superior to a lateral view. Limitations: A limitation to this study is the design as a technical report. A future prospective study is warranted. Conclusions: Modified swimmer’s view can serve as a primary method of visualizing the lower CMBTZs or an alternate view when a lateral view is unable to clearly demonstrate target landmarks. This can improve the ease, accuracy, and safety of performing diagnostic cervical medial branch blocks (CMBBs). Key words: Swimmer’s view, cervical medial branch block, facet joint, fluoroscopy

Published
2018
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200. Anisocytosis and leukocytosis are independently related to survival after transcatheter aortic valve replacement

Author

Jarrod E. Dalton, Guilherme F. Attizzani, Myttle Mayuga, Sadeer G. Al-Kindi, Anthony E. DeCicco, Nicholas T. Funderburg, Sahil A. Parikh, Eugene H. Blackstone, Marco A. Costa, Daniel I. Simon, Chris T. Longenecker, Ahmad Alkhalil, Michael M. Lederman, and David A. Zidar

Subjects
Erythrocyte Indices, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Transcatheter aortic, Leukocytosis, medicine.medical_treatment, MEDLINE, 030204 cardiovascular system & hematology, Severity of Illness Index, Gastroenterology, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Valve replacement, Risk Factors, Internal medicine, Severity of illness, Humans, Medicine, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Retrospective cohort study, Aortic Valve Stenosis, General Medicine, medicine.disease, Survival Analysis, 030104 developmental biology, Anisocytosis, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published
2018
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