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The majority of research administrators (RAs) in SRA and NCURA have had little formal training in research design and methodology. RAs with diverse backgrounds are needed to administer the various aspects of external grants and contracts. In this paper, the view is supported that all RAs would function more effectively and enjoy their work more if they had a better understanding of research. Examples are given to demonstrate how some of the basic principles of research design can be readily conveyed to individuals with little or no research training. Consideration of how RAs might benefit from developing a better understanding of research are presented and discussed. Finally, suggestions are offered on how professional organizations, such as SRA and NCURA, can contribute to the professional development of their members by providing structured opportunities to learn about research., INTRODUCTION Research administrators (RAs) come from a variety of educational backgrounds and perform a variety of functions related to obtaining and administering external grants and contracts (Rose 1991; D'Agostino, Nivin, [...]

Certain recommendations are given to engineering firms that are considering the prospect of international strategy in an attempt to adapt to the fast- changing business environment. Firms are urged to study their markets and partners beforehand, seek government aid, get early legal and tax advice, think long-term and get clear written agreements with agents. The International Federation of Consulting Engineers is likewise suggested, as they produce internationally-used contract documents which ensure fairness for both clients and engineering firms.

A photographic record of people's interactions in Washington, DC, from the late 19th century to 1954 when legalized separation of race ended, gives information about the evolution of race relations and segregation patterns. Washington had separate school and recreation systems, and segregation continued even after World War II. African Americans, who were employed in custodial jobs under their white superiors, created their own cultural institutions. Racism and discrimination began to decline only during 1948 to 1954 with the revival of Reconstruction laws.

The slicing of pizza is mathematically investigated by the application of Riemann hypothesis. A unit square pizza is cut by considering its lower left corner as zero and its upper right corner as (1,1). The pizza is cut along lines which have an integer with a y-intercept and a slope with a positive integer. The various slices and dimension of these slices are determined using Riemann hypothesis.

The Boethian influences in Chaucer's 'Canticus Troili' are examined. Chaucer adapted this piece from Petrarch's 'Canzoniere' which, incidentally, also has similarities to 'Boece'. The syntax, structure, lyrics and subject matter of 'Canticus' bears similarity to 'Boece' and 'Canzoniere'. The subject matter deals with the contradictions of life such as the good suffering and love overpowering, giving contradictory feelings. These Boethian elements are interwoven into the text and reflect Chaucer's admiration for the philosophy.

'Washington: Symbol and City' opened at the National Building Museum on Jun 7, 1991. The exhibition uses models to illustrate Washington around 1900 and the development of Washington during the 20th century. The design and the symbolism of such monuments as the Lincoln Memorial and the White House are described. The models are accompanied by photographs, drawings, letters, prints, advertisements and three-dimensional objects.

Research personnel who handle laboratory animals infected with lymphocytic choriomeningitis virus (LCMV) may have a risk of developing lymphocytic choriomeningitis. Lymphocytic choriomeningitis is an inflammation of the membranes surrounding the brain that is caused by LCMV. Of 31 laboratory personnel who worked with LCMV-infected mice at a research institute, seven were infected with LCMV, and one had a probable LCMV infection. Infected employees were more likely to clean the cages of infected mice or change their bedding and water than non-infected employees who worked with the mice. At the time of the outbreak of LCMV infections in research personnel, the number of experiments involving LCMV-infected mice increased, and the duration of experiments was increased from three to four weeks to three to four months.

Background: In the phase III eculizumab for refractory generalized myasthenia gravis REGAIN study [ClinicalTrials.gov identifier: NCT01997229] and its open-label extension (OLE) [ClinicalTrials.gov identifier: NCT02301624], patients with treatment-refractory antiacetylcholine receptor antibody-positive generalized myasthenia gravis had clinically meaningful improvements with eculizumab versus placebo. This subgroup analysis evaluated data from patients with a recent history of chronic intravenous immunoglobulin (IVIg) use before study entry. Methods: The subgroup comprised patients who had received IVIg at least four times in 1 year, with at least one IVIg treatment cycle during the 6 months before the first REGAIN study dose. Data from REGAIN and the OLE were analyzed. Response to eculizumab versus placebo was assessed using four validated, disease-specific measures. Incidences of exacerbations and safety endpoints were recorded. Results: The subgroup had similar patient and disease characteristics as the overall REGAIN population. Clinical assessments showed sustained eculizumab efficacy during REGAIN and the OLE over 18 months. Patients receiving placebo in REGAIN experienced rapid improvements in assessment scores when treated with eculizumab in the OLE. There was a lower rate of disease exacerbations with eculizumab than with placebo during REGAIN, and eculizumab was well tolerated. Conclusion: Eculizumab treatment, compared with placebo, results in meaningful clinical improvements and fewer disease exacerbations for patients who previously received chronic IVIg. Trial registration: REGAIN [ClinicalTrials.gov identifier: NCT01997229]; REGAIN open-label extension [ClinicalTrials.gov identifier: NCT02301624]. [ABSTRACT FROM AUTHOR]

Infrared studies on the (super 12)CO- and (super 13)CO-incubated bifunctional CODH/ACS from M. thermoacetica provides with a direct evidence that CO binds to metal ions in both clusters A and C. The results indicate that the bifunctional enzyme from M. thermoacetica does not contain intrinsic carbonyl ligands in cluster C as it is been proposed in the monofunctional CODH from R. rubrum.

Presents a study of the charge collection of single event effects. Analysis of the collection process; Description of the concept of enhanced prompt charge collection; Description of various parameters that are affected by the collection mechanism.

We examined the pharmacologic activity of a putative toxin (pPfTx) produced by Pfiesteria piscicida by characterizing the signaling pathways that induce the c-fos luciferase construct in [GH.sub.4][C.sub.1] rat pituitary cells. [...]

Lipogenesis was measured with glucose-2-14C and acetate-1-14C in the everted aortas of normal and atherosclerotic rabbits. More glucose-2-14C than acetate-1-14C was incorporated into lipids in both the normal and the atherosclerotic aorta.Radiocarbon from glucose-2-14C appeared mainly in triglycerides and phospholipids with a small amount in cholesteryl esters. Incorporation increased almost threefold with atherosclerosis, most of the radioactivity being in the glycerol moiety; radioactivity was predominantly in carbon 2 of glycerol.About 70% of the acetate-1-14C incorporated into phospholipids and triglycerides was in the fatty acids, and the remainder was in glyceride-glycerol; 98% of the radioactivity in cholesteryl esters was in the fatty acid moiety. Incorporation into cholesteryl esters was increased most during the development of atherosclerosis.Fatty acid synthesis was similar from both acetate-1-14C and the 2 carbon unit derived from glucose-2-14C, viz., predominantly de novo synthesis of fatty acids with 14 and 16 carbon atoms, and elongation for those of 18 carbons and longer.

Subcellular fractions of aorta of squirrel monkey (Saimiri sciureus) were examined for their ability to synthesize and elongate fatty acids. High-speed supernate (HSS) incorporated substantial quantities of malonyl CoA into fatty acids while acetyl CoA was much less effectively utilized. Acetyl-CoA carboxylase activity exceeded the amount of acetyl CoA incorporated into fatty acids and thus does not account for the low incorporation of this substrate. Microsomes used malonyl CoA and acetyl CoA equally well; mitochondria incorporated either acetyl CoA or acetate. The amounts of substrate incorporated into fatty acids (mμmoles/mg of protein per hr) were 2.3 for HSS, 1.2 for microsomes, and 0.9 for mitochondria.The synthesized fatty acids were separated by gas-liquid chromatography, radioassayed, extracted from the scintillation fluid, and decarboxylated. HSS completely synthesized palmitic and stearic acids from malonyl CoA. Microsomes and mitochondria utilized acetyl CoA to elongate endogenous fatty acids and gave mainly palmitic, stearic, and C18 and C20 monoenoic acids, with lesser amounts of other saturated and unsaturated fatty acids. A significant quantity of malonyl CoA was utilized by microsomes to yield a fatty acid tentatively identified as docosapentaenoic. Radioactive fatty acids are incorporated into various lipid classes by the particulate preparations.These studies demonstrate that aortic tissue in a nonhuman primate is able to carry out several processes of fatty acid metabolism and that the aortic synthesis and elongation of fatty acids may play an important role in providing fatty acids for incorporation into aortic lipids.