151. Prognosis and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study
- Author
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Ali Nasermoaddeli, Katsuyuki Miura, Hideaki Nakagawa, Yoshiyuki Soyama, Yuko Morikawa, Yutaka Inaba, Akira Kitabatake, and Akira Matsumori
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Bundle-Branch Block ,Cardiomyopathy ,Kaplan-Meier Estimate ,Japan ,Internal medicine ,Epidemiology ,medicine ,Humans ,Survival rate ,Aged ,Proportional Hazards Models ,Ejection fraction ,Left bundle branch block ,Proportional hazards model ,business.industry ,Hypertrophic cardiomyopathy ,Stroke Volume ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Prognosis ,medicine.disease ,Health Surveys ,Surgery ,Survival Rate ,Heart Failure and Cardiomyopathy ,Epidemiologic Studies ,Cohort ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Objective: To investigate prognosis and prognostic factors in patients with hypertrophic cardiomyopathy (HCM) in Japan. Design: A nationwide epidemiological study. Setting: Hospitals selected randomly from among all hospitals in Japan. Patients: Clinical and epidemiological information for 2155 patients with HCM were collected in 1999. Main outcome measures: Patients were classified on the basis of baseline prognostic factors. Survival rates up to 5 years were calculated by Cox’s proportional hazard model for 1605 patients. Results: During the follow-up period, 241 deaths were recorded. The crude 5-year survival rate for the entire cohort was 86% (95% CI 84 to 88), and annual mortality ranged from 2.2% to 3.0%. A higher cardiothoracic ratio on chest x ray (HR 1.61; 95% CI 1.26 to 2.05, with 1 SD (6.2%) increase), a lower left ventricular ejection fraction (HR 1.42; 95% CI 1.20 to 1.69, with 1 SD (13%) decrease) and the presence of left bundle branch block (HR 3.14; 95% CI 1.28 to 7.71) were independently associated with a poorer prognosis, whereas the presence of apical hypertrophy at baseline (HR 0.58; 95%CI 0.36 to 0.92) predicted a better chance of survival. Conclusions: The nationwide survey of patients with hypertrophic cardiomyopathy yielded important information on its prognosis and prognostic factors. These observations afford, for the first time, a measure of risk stratification in patients with HCM in Japan.
- Published
- 2007