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Lack of Association between Human G-Protein β3 Subunit Variant and Overweight in Japanese Workers*
- Source :
- Obesity Research. 12:4-8
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- We examined the association of the G-protein beta3 subunit gene (GNB3) C825T polymorphism with overweight in Japanese workers. This cross-sectional study used multivariate analysis to investigate whether a polymorphism in the C825T polymorphism was associated independently with overweight when factors such as age and lifestyle were taken into account. The study in 1453 men and 1172 women involved identifying subjects with the C825T genotype using the polymerase chain reaction, followed by restriction fragment-length polymorphism analysis. Overweight was defined as a BMI > or = kg/m(2). Genotype distributions for C825T in overweight men (CC = 80, CT = 162, TT = 80) and women (CC = 52, CT = 91, TT = 40) were not significantly different from normal-weight men (CC = 278, CT = 588, TT = 265) and women (CC = 242, CT = 549, TT = 198). The allele distributions were also not significantly different between either sex. The power of the study was estimated as 98% in men and 81% in women based on the allelic frequencies reported in a previous positive study in Chinese subjects. Multiple logistic regression analysis showed that the genotype was not significantly associated with overweight. In conclusion, this study indicated that the GNB3 C825T polymorphism is not a significant factor for overweight in Japanese people.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Genotype
Cross-sectional study
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Overweight
Polymerase Chain Reaction
Body Mass Index
Endocrinology
Japan
Polymorphism (computer science)
Internal medicine
medicine
Humans
Obesity
Life Style
Genetics
Analysis of Variance
Polymorphism, Genetic
business.industry
Public Health, Environmental and Occupational Health
Middle Aged
medicine.disease
Heterotrimeric GTP-Binding Proteins
Cross-Sectional Studies
Logistic Models
Female
medicine.symptom
business
Body mass index
Polymorphism, Restriction Fragment Length
Food Science
GNB3
Subjects
Details
- ISSN :
- 10717323
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Obesity Research
- Accession number :
- edsair.doi.dedup.....7e1842195ebdafd9bd0c3cdbb7cbc7f2