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The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more. - Contains contributions from both academia and industry to maximize the cross-fertilization of differing perspectives on opioid system function in health and disease - Studies the opioid system as the interface between the brain's cognitive and motivational systems

Since its first publication more than 35 years ago, MacSween's Pathology of the Liver, by Drs. Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher, has established itself as the definitive reference on liver pathology. The 7th Edition continues the tradition of excellence with more than 1,000 high-quality illustrations, coverage of the new and emerging diagnostic applications and techniques that pathologists must be familiar with, an up-to-date review of drug-induced injury, and much more. A must-have for every surgical pathologist, MacSween's remains the most authoritative and comprehensive book in its field. Provides comprehensive, state-of-the-art coverage of all malignant and benign hepatobiliary disorders from an international'who's who'in the field. Helps you quickly recognize the wide variety of liver appearances that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. Features 1,000+ full-color illustrations that provide a complete visual guide to each tumor or tumor-like lesion and assist in the recognition and diagnosis of any tissue sample you're likely to encounter. Incorporates relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools required to master the latest breakthroughs in diagnostic technology. Includes an updated chapter on mechanisms of liver disease, including coverage of regression and remodeling of disease and new information on next generation sequencing; an up-to-date review of drug-induced injury, including the effects of herbal and alternative medicines. Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

This guide focuses on the answers to patient questions that are frequently posed to providers who care for patients with GI motility disorders. Additionally, the text guides clinicians through the complicated diagnostic and therapeutic/management approaches to motility disorders, including common and specialized tests, drug initiation, medications side effects, and disease complications. Written by experts in the field, Gastrointestinal Motility Disorders: A Point of Care Clinical Guide is a valuable reference for busy clinicians who need the best evidence-based answers to patient questions at their fingertips.

Das Thema Multimorbidität gewinnt zunehmend an Aufmerksamkeit, denn das gleichzeitige Bestehen mehrerer Erkrankungen führt zu großen medizinischen und sozialpolitischen Herausforderungen. Während dies vornehmlich als ein Problem des höheren Lebensalters angesehen wird, betrifft es im Bereich der Neuropsychiatrie auch viele Menschen im erwerbsfähigen Alter. Bislang sind neuropsychiatrische Aspekte hierbei wenig betrachtet worden. Es gibt bisher kein anerkanntes Konzept für Multimorbidität. In diesem Buch wird ein neu entwickeltes Modell zu deren Einteilung, das neuropsychiatrische und Suchterkrankungen berücksichtigt, vorgeschlagen und erörtert. Die bei einer Multimorbidität oft zahlreichen Funktionsstörungen führen zu einer erheblichen Einschränkung der Lebensqualität und einer erhöhten Inanspruchnahme medizinischer Leistungen. Die bei der Komplexität der Symptomatik häufig erforderliche Polypharmazie und andere therapeutische Möglichkeiten werden eingehend betrachtet.

Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion of all the aspects associated with gut microbiota early colonization, its development and maintenance, and its symbiotic relationship with the host to promote health. Chapters illustrate the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, while mediating inflammatory processes involved in the etiology of many chronic disease conditions. Details are provided on the primary etiological factors of chronic disease, the effects of gut dysbiosis and its associated disease conditions, while providing an overview of therapeutic strategies involving dietary fiber and prebiotics, fecal microbiota transplantation therapy and probiotics. Throughout the chapters, a comprehensive review of peer-reviewed animal and human studies is provided as evidence related to the history of human exposure, safety, tolerance, toxicity, nomenclature, and clinical efficacy of utilizing prebiotic fructans, s, as well as probiotic intervention, and dietary modification in the prevention and intervention of chronic disease conditions. With common use today of pharmaceutical medicine in treating symptoms, and frequent overuse of antibiotics in chronic disease within mainstream medical practice, understanding the etiological mechanisms of dysbiosis-induced chronic disease, and natural approaches that offer prevention and potential cures for these diseases is of vital importance to overall human health. - Details the complex relationship between human microbiota in the gut, oral cavity, urogenital tract and skin as well as their colonization, development and impact of factors that influence the relationship - Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease - Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification, and pro- and pre-biotics in preventing and intervening in chronic disease

Widely recognized Paleo expert and nutritionist, Nora Gedgaudas presents a scientific, accessible high-fat diet for maintaining health, losing weight, and reversing some chronic diseases.'Wonderfully actionable, compassionately taking the reader from'why'to'how'.'Dr David Perlmutter, author of the international bestseller Grain BrainExpert nutritionist Nora Gedgaudas, bestselling co-author of Going Paleo with Pete Evans, explains the science and evidence behind the revolutionary new health message: Eat fat to burn fat. In her new book, Primal Fat Burner, she explains the benefits behind a ketogenic (or fat-burning) diet, which switches your metabolism from a dependence on sugar to running on healthy fats. As Gedgaudas reveals, numerous studies in recent years refute the long-promoted anti- saturated fat and anti-cholesterol agenda. Now Gedgaudas explains the science that fat isn't a'no-no'but rather a'yes-yes'-if you know the right kinds of fats to eat. In her accessible, enjoyable style, she also lays out a practical meal plan with recipes.When you follow a ketogenic diet, you consume fewer calories overall, feel better, look better, think clearer, and live longer.

THE HIGHLY SUCCESSFUL, PROVEN PROGRAMME FOR REVERSING THE SYMPTOMS OF ALZHEIMER'S DISEASE Alzheimer's Disease affects over 47 million people worldwide but 90 per cent of cases can be prevented. Based on the largest clinical study to date, The Alzheimer's Solution, by leading neurologists and Alzheimer's specialists Drs Dean and Ayesha Sherzai, provides the essential practical tools you and your family need to reverse the symptoms and prevent cognitive decline. Alzheimer's disease isn't a genetic inevitability and a diagnosis doesn't need to spell the end. Ninety per cent of us can avoid getting it and for the 10 per cent with strong genetic risk, the disease can be delayed by 10 to 15 years. This is based on the remarkable results Dr Dean Sherzai and Dr Ayesha Sherzai have seen in their own clinic. This much-needed revolutionary book provides: •The groundbreaking and successful programme for the treatment of Alzheimer's •A practical 5-part plan for reversing and preventing Alzheimer's, covering food, sleep, exercise, stress-management and activities that keep your brain healthy •A questionnaire for assessing your risk level and daily guides for optimising your brain's health •Delicious and simple brain-healthy recipes for you and the family to enjoy Praise for The Alzheimer's Solution:'The Sherzais'research is changing the landscape of neurodegenerative diseases as well as the outcomes for thousands of patients.'Dr Keith Black, Chairman of the Neurosurgery Department and Director of the Maxine Dunitz Neurological Institute, Cedars-Sinai Medical Center'A very important book.'Dr Dilip Jeste, Distinguished Professor of Psychiatry and Neurosciences, University of California, San Diego School of Medicine'The Alzheimer's Solution supplies everything you need to know about the prevention of this disease'Dr Joel Fuhrman, New York Times best-selling author of Super Immunity, Eat to Live and The End of Diabetes, President, Nutritional Research Foundation'This [is a] thorough, thoughtful, empowering, and timely book…Every family should own, and apply, The Alzheimer's Solution.'Dr David Katz, founding director of Yale University's Yale-Griffin Prevention Research Center, founder and president of the True Health Initiative, and author of Disease-Proof

Sleep and Neurologic Disease reviews how common neurologic illnesses, such as Parkinson's Disease and Alzheimer's dementia impact sleep. In addition, the book discusses how common primary sleep disorders influence neurologic diseases, such as the relationship between obstructive sleep apnea and stroke, as well as their association with various primary headache disorders and epilepsy syndromes. The utilization of sleep technology, such as polysomnography, multiple sleep latency testing, actigraphy, laboratory and CSF testing is also covered. The book is written for the practicing neurologist, sleep physician, neuroscientist, and epidemiologist studying sleep. - Reviews how common neurological illnesses impact sleep and the impact sleep disorders have on neurologic disease - Up-to-date, comprehensive overview written for practicing neurologists, sleep physicians, neuroscientists, and epidemiologists - Includes informative discussions on sleep physiology, circadian rhythms, sleep and stroke, and treatment options for neurologists

Popular nutritionist Nora Gedguadas returns with advice that may sound counterintuitive: eat fat to burn fat. In Primal Fat Burner she explains the benefits and science behind a ketogenic (or fat-burning) diet, which switches your metabolism from a dependence on sugar to running on healthy fats. As Gedgaudas reveals, numerous studies in recent years refute the long-promoted anti-saturated fat and anti-cholesterol agenda. Now Gedgaudas explains the science that fat isn't a'no-no'but rather a'yes-yes'- if you know the right kinds of fats to eat. In her accessible, enjoyable style, she also lays out a practical meal plan with recipes. When you follow a ketogenic diet, you consume fewer calories overall! Author of the bestselling Grain Brain, Dr. David Perlmutter writes in his foreword that Primal Fat Burner is'wonderfully actionable, compassionately taking the reader from'why'to'how.''On this diet, you efficiently and effectively metabolise fat (ketones and free fatty acids) as your primary source of fuel, rather than glucose from carbs, starches and sugars. Because fat is so satisfying, you naturally wind up eating less - without feelings of hunger or deprivation. And natural dietary fat is ultimately key to optimum health and longevity. Gedgaudas communicates a real appreciation for and understanding of the central role that dietary fat plays in your body and brain, and explains how you can eat to feel better, look better, think clearer and live longer.

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system's function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington's disease) and elderly (Alzheimer's disease, Parkinson's disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

International Review of Cell and Molecular Biology (IRCMB), Volume 330 includes comprehensive and detailed reviews on the current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. IRCMB ranks high amongst scientific journals dealing with cell biology. - Includes comprehensive and detailed reviews on the current advances in cell and molecular biology - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists, drawn from international sources - Offers a wide range of perspectives on specific subjects

Der demografische Wandel zu einer älteren Gesellschaft ist in vollem Gange. Bei Älteren erfordern die vielfältigen interagierenden Probleme ein multidimensionales Management, das z.B. Gastroenterologen, Geriater, Ernährungsmediziner, Pharmakologen aber auch die Pflege einschließt. In diesem Fachbuch sind erstmals im deutschsprachigen Raum alle wichtigen Problemfelder der geriatrischen Gastroenterologie zusammengefasst. Es vermittelt anschaulich und praxisnah die speziellen Anforderungen bei der Diagnostik und Therapie geriatrischer Patienten im Fachbereich Gastroenterologie.Für die 2. Auflage des Buches wurden alle bestehenden Kapitel überarbeitet und auf den jeweils neuesten Stand gebracht. Dabei wurden die aktuellen Leitlinien und Studienergebnisse eingearbeitet. Komplett neue Kapitel gehen auf den Umgang mit dementen, deliranten und den nicht-einwilligungsfähigen Patienten in der geriatrischen Gastroenterologie ein. Eine substantielle Erweiterung des Buches ist ein neues Pflegekapitel, das alle für die Pflege des geriatrisch-gastroenterologischen Patienten relevanten Punkte behandelt.

This ​book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.

The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody's Core Title for 2020! Goodman & Gilman's: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

Das umfangreiche Nachschlagewerk von Möller, Laux und Kapfhammer darf zu Recht als Standardwerk für Psychiatrie im deutschsprachigen Raum bezeichnet werden. Die aktuelle Auflage wurde komplett überarbeitet und aktualisiert, zahlreiche Autoren tragen mit ihrem Expertenwissen dazu bei, dass sowohl Ärzte in Weiterbildung als auch Fachärzte für Psychiatrie und Psychotherapie auf alle Fragen umfassende Antworten erhalten. Insgesamt vier Bände enthalten alle Grundlagen der Psychiatrie, Prinzipien der Diagnostik und Behandlung und selbstverständlich einen umfangreichen Teil zu den einzelnen Störungen.Von der Geschichte über Klassifikation, Diagnostik und Therapie aller Krankheitsbilder bis hin zu speziellen Aspekten der Psychiatrie finden Sie hier das gesamte Wissen auf aktuellem Stand.

Alzheimer's disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer's disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer's disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer's disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer's disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.

The present book offers a set of chapters which describes the procedure for drug treatment of the principal diseases that older people suffer from. In the pharmacological concept, it has been established that pharmacokinetics is the most useful strategy to determine the prime schedule of different medications for seniors. These strategies can be applied in a clinic or nursing home as well as in a home. The initial chapter describes optimizing this technique, continuing with a description of the most common illnesses due to old age. The next chapter discusses deep concepts of pharmacokinetics. Afterwards, some examples of pharmacokinetics studies are described. The text finishes with a description based on previous studies about the patterns of drug consumption in older individuals. The authors hope this material can be useful first to aid the elderly population and can motivate the investigation of pharmacokinetic studies, since this material is lacking in the global context.

A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders. - Focuses on specific areas in which the microbiota has been implicated in gut-brain communication - Examines common mechanisms and pathways by which the microbiota may influence brain and behavior - Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior

This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories andwith reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in differentformats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.

A comprehensive reference on external contributing factors in psychopathology Developmental Psychopathology is a four-volume compendium of the most complete and current research on every aspect of the field. Volume Three: Risk, Disorder, and Adaptation explores the everyday effects and behaviors of those with behavioral, mental, or neurological disorders, and the disorder's real-world impact on their well-being. Now in its third edition, this comprehensive reference has been fully updated to better reflect the current state of the field, and detail the latest findings in causation, intervention, contextual factors, and the risks associated with atypical development. Contributions from expert researchers and clinicians explore the effects of abuse and traumatic stress, memory development, emotion regulation, impulsivity, and more, with chapters specifically targeted toward autism, schizophrenia, narcissism, antisocial behavior, bipolar disorder, and borderline personality disorder. Advances in developmental psychopathology have burgeoned since the 2006 publication of the second edition, and keeping up on the latest findings in multiple avenues of investigation can be burdensome to the busy professional. This series solves the problem by collecting the information into one place, with a logical organization designed for easy reference. Learn how childhood experiences contribute to psychopathology Explore the relationship between atypical development and substance abuse Consider the impact or absence of other developmental traits Understand the full risk potential of any behavioral or mental disorder The complexity of a field as diverse as developmental psychopathology deepens with each emerging theory, especially with consideration of the multiple external factors that have major effects on a person's mental and emotional development. Developmental Psychopathology Volume Three: Risk, Disorder, and Adaptation compiles the latest information into a cohesive, broad-reaching reference with the most recent findings.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Integrative Therapies for Depression: Redefining Models for Assessment, Treatment and Prevention summarizes emerging theories and research findings on various nonpharmaceutical therapies to treat mood disorders.Supported by the review of nearly 3000 scientific studies, the book describes the concepts of inflammation, genetics, hormonal imbalance, g

The fourth edition of Psychopathology is the most up-to-date text about the etiology and treatment of the most important psychological disorders. Intended for first-year graduate students in clinical psychology, counseling psychology, and related programs, this new edition, revised to be consistent with the DSM-5, continues to focus on research and empirically-supported information while also challenging students to think critically. The first part of the book covers the key issues, ideas, and concepts in psychopathology, providing students with a set of conceptual tools that will help them read more thoroughly and critically the second half of the book, which focuses on specific disorders. Each chapter in the second and third sections provides a definition, description, and brief history of the disorder it discusses, and outlines theory and research on etiology and empirically-supported treatments. This edition also features a companion website hosting lecture slides, a testbank, an instructor's manual, case studies and exercises, and more.

Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.

Sinnvolle Kombinationstherapie in der PsychiatrieIn diesem Buch werden alle verfügbaren Informationen zur Kombinationstherapie bei psychischen Krankheitsbildern zusammengefasst und kritisch kommentiert. Psychopharmaka sind integraler Bestandteil einer differenzierten Therapie psychischer Erkrankungen. Prinzipiell wird die Monotherapie empfohlen, in der klinischen Praxis werden aber häufig Kombinationsbehandlungen durchgeführt, obwohl nur eine geringe Zahl kontrollierter Studien zu deren Effizienz vorliegt. Die 3. Auflage wurde komplett aktualisiert und bietet einen aktuellen und umfassenden Überblick zu den unterschiedlichen Möglichkeiten der psychopharmakologischen Kombinationsbehandlung. Völlig neu ist auch der praxisrelevante Zugang, sodass auch niedergelassene Ärzte von der Lektüre profitieren. Der Inhalt· Behandlung depressiver Störungen· Behandlung der Schizophrenie· Behandlung bipolarer Störungen · Behandlung von Menschen mit geistiger Behinderung· Behandlung von Persönlichkeits- und Verhaltensstörungen · Gerontopsychiatrie· Konsiliar- und Liaisonpsychiatrie· Kombinationen mit Psychopharmaka in der Behandlung von Angst- und Zwangsstörungen · Kombinationen in der Behandlung forensischer PatientenDie HerausgeberPriv.-Doz. Dr. med. Thomas Messer, Chefarzt der Danuvius Klinik Pfaffenhofen, Fachklinik für Psychiatrie, Psychotherapie und Psychosomatik, Lehreinrichtung der TU MünchenProf. Dr. Max Schmauß, Ärztlicher Direktor des Bezirkskrankenhauses Augsburg

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. - Enhanced encyclopedic format with drug monographs now organized alphabetically - Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions - Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing - Extensive bibliography with over 40,000 references - A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

Demystifies Biomedical and Biological Big Data AnalysesBig Data Analysis for Bioinformatics and Biomedical Discoveries provides a practical guide to the nuts and bolts of Big Data, enabling you to quickly and effectively harness the power of Big Data to make groundbreaking biological discoveries, carry out translational medical research, and implem

Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden. This book, volume 4 of the Advances in Alzheimer's Disease book series which is published in coordination with the Journal of Alzheimer's Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment. Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.

The primary objective of this book is to provide readers with up-to-date knowledge of recent advances in serotonin research across different fields. The research topics include the following aspects: The first chapter provides novel evidence supporting the involvement of genetic variants in the serotonin transporter and receptor genes in the etiology of nicotine dependence and alcoholism through gene-by-gene interaction. The second chapter provides an update on genes and genetic variants in the serotonergic network that have been implicated in sudden infant death syndrome. The third chapter discusses how aggressive social stress such as absence of electricity, cold weather, shortage of food, and social isolation influence the development of chronic stress, pathological aggression, and formation of killer and self-killer organisms and how the distribution and concentration of serotonin in the brain are changed along with these physiological and pathological conditions. Chapter Four shows that serotonin signaling influences many developmental processes both in the central nervous system and in the peripheral organs, and Chapter Five reviews new evidence on the involvement of the brain's serotonergic system in the regulation of food intake, digestion, and metabolism in fish. The last two chapters describe the identification and purification of a novel serotonin-modulating anticonsolidation protein and show how this protein is involved in memory formation and suppression of drug addiction and epileptic seizures in Chapter 6 and in regulation of mutagenesis and adaptation in Chapter 7. Collectively, this book provides a broad view of recent advances in serotonin research in different species of animals. It is our hope that the book will provide readers with a deeper understanding of these new developments in serotonin research across different disciplines.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems. - Expertise of the contributors - Coverage of a vast array of subjects - In depth current information at the molecular to the clinical levels

Encyclopedia of Mental Health, Second Edition, Four Volume Set tackles the subject of mental health, arguably one of the biggest issues facing modern society. The book presents a comprehensive overview of the many genetic, neurological, social, and psychological factors that affect mental health, also describing the impact of mental health on the individual and society, and illustrating the factors that aid positive mental health. The book contains 245 peer-reviewed articles written by more than 250 expert authors and provides essential material on assessment, theories of personality, specific disorders, therapies, forensic issues, ethics, and cross-cultural and sociological aspects. Both professionals and libraries will find this timely work indispensable. - Provides fully up-to-date descriptions of the neurological, social, genetic, and psychological factors that affect the individual and society - Contains more than 240 articles written by domain experts in the field - Written in an accessible style using terms that an educated layperson can understand - Of interest to public as well as research libraries with coverage of many important topics, including marital health, divorce, couples therapy, fathers, child custody, day care and day care providers, extended families, and family therapy

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

Determining the biological bases for behavior, and the extent to which we can observe and explain their neural underpinnings, requires a bold, broadly defined research methodology. The interdisciplinary entries in this handbook are organized around the principle of'molecular psychology,'which unites cutting-edge research from such wide-ranging disciplines as clinical neuroscience and genetics, psychology, behavioral neuroscience, and neuroethology. For the first time in a single volume, leaders in diverse research areas use molecular approaches to investigate social behavior, psychopathology, emotion, cognition and stress in healthy volunteers, patient populations, and an array of non-human species including rodents, insects, fish, and non-human primates. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.

​Pediatric Skin of Color is the first textbook devoted to the issues of pediatric skin of color. In 2052, more than fifty percent of the United States will be of color, and currently seventy percent of the world's population is termed of color. Therefore, this book fills the need for an instructional and educational referebce work regarding these populations. Pediatric Skin of Color​ discusses the biology and clinical data regarding normal skin, skin conditions exclusive to individuals of color, systemic diseases of individuals of color that have a strong component of skin involvement, and the appearance and demographics of common skin diseases, comparing Caucasian and all skin of color populations. Written for dermatologists and pediatric dermatologists, this text includes data on African American, Asian (Southeast and East), Hispanic/Latino, and Middle Eastern patients, as well as Indigenous populations (i.e. Native Americans, Aborigines).

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Le cloisonnement que l'on observe dans le champ de la santé mentale de l'enfant nécessite que les spécialistes s'affranchissent du strict périmètre de leur discipline pour adopter une approche plus globale.L'approche basée sur les preuves, dérivée de l'evidence based medicine anglo-saxonne, offre une vision élargie de la pédopsychiatrie en permettant de s'extraire de la stricte soumission aux conclusions de la recherche pour donner à la pratique, dans une certaine mesure, la possibilité de valider des choix de prise en charge pluridisciplinaires.

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

PET and SPECT of Neurobiological Systems combine the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to all with an interest in the field of clinical or preclinical neuroscience. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology'.

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details.Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. - Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise - Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics - Covers newer technologies– next generation sequencing, proteomics, metabolomics - Provides information on animal models, lymphoblastoid cell lines, stem cells - Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues - Includes chapters on the global implications of pharmacogenomics

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. - Authors are the leading experts in the field of brain extracellular matrix in health and disease - Book covers the most important aspects of brain extracellular matrix in health and disease - Interesting for both scientists and clinicians

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas. - Expertise of contributors - Subject including practical drug development from basic science, as translational research taste - Structure of contents focusing on two CNS areas for diseases (neurology and psychiatry)

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington's syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

As a dynamic, interdisciplinary field, behavior genetics and its evolution are being followed closely by scientists across the psychological and medical domains. The discoveries surrounding the human genome and the advancement in molecular genetic technologies have led to studies becoming increasingly sophisticated and yielding yet more conclusive and useful results. This is certainly the case in the area of child and adult psychopathology. Behavior Genetics of Psychopathology summarizes the state of the field, examiningthe role of genes and environment as they affect common neurodevelopmental and psychiatric conditions. Emphasizing key research areas (comorbidities, twin studies, the integration of methods), the book assesses the current literature, offers up-to-date findings, sorts through lingering controversies, and identifies a clear future agenda for the field. Expertly-written chapters focus on issues of both general salience that shape behavior genetics of psychopathology, to specific disorders of major clinical importance, among them: ADHD: the view from quantitative genetic research.Autism spectrum disorders and their complex heterogeneityGenetic influences on anxiety and depression in childhood and adolescence.Evidence for etiologically-defined subgroups within the construct of antisocial behavior.Sleep and psychopathology: the reasons for their co-occurrence. Behavioral genetic approaches to the etiology of comorbidity.Epigenetics of psychopathology. This combination of timeliness and depth of coverage make Behavior Genetics of Psychopathology a frontline resource for behavior geneticists, psychologists, psychiatrists, and neuroscientists, and is perfectly suited to graduate students looking to join these fields.

Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.

Emotions suffuse our lives: a symphony of feeling - usually whispering and murmuring in pianissimo but occasionally screaming and shouting in fortissimo crescendo - filling every waking moment and even invading our dreams. We can always be conscious of how happy, sad, annoyed, or anxious we feel, and also of the feelings we have relative to other persons: pride, envy, guilt, jealousy, trust, respect, or resentment. Developments in brain imaging and in capturing nuances of nonverbal display now enable the objective study of emotion and how biologically-based primary emotions relate to higher-level social, cognitive, and moral emotions. This book presents an integrated developmental-interactionist theory of emotion, viewing subjective feelings as voices of the genes: an affective symphony composed of dissociable albeit interactive neurochemical modules. These primordial voices do not control, but rather cajole our behavior with built-in flexibility, enabling the mindful application of learning, reason, and language.

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material