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Introduction: Questionnaire based surveys are an inexpensive way of collective information on morbidity patterns. This study aims to determine the agreement between morbidities recorded by the survey staff (TA) through questionnaire and that revealed via examination by medical officer. Methodology: A long term follow up epidemiological study was launched in 1985 covering a cohort of 80021 gas exposed people and 15931 unexposed people. A list of 40 symptoms was provided for recording the morbidities The International Classification of Diseases was followed for coding the morbidity by Medical Offic- ers. Data presented here were collected during January-December, 2016 and total 3393 multi morbid persons, ageing more than 32 years from cohort were taken. For finding the agreement of pattern morbidity between the technical assistant and the medical doctors, Kappa statistics was used. Results: Overall Kappa ‘moderate (0.41-0.60)’ agreement was ob- served in respiratory morbidity. In ophthalmic morbidity ‘Sub- stantial (0.61-0.80)’ was observed. We found overall (Respiratory, Ophthalmic, GIT and Skin) ‘Moderate (0.41-0.60)’ agreement. Conclusions: Morbid agreement analysis established that substan- tial agreement between TA and medical doctor in affected areas where as in control area moderate agreement were observed. It is better to verify all symptomatic morbid persons by medical officer.

Achieving research reproducibility is a precarious aspect of scientific practice. However, many studies across disciplines fail to be fully reproduced due to inadequate dissemination methods. Traditional publication practices often fail to provide a comprehensive description of the research context and procedures, hindering reproducibility. To address these challenges, this article presents a tutorial on reproducible research using the R programming language. The tutorial aims to equip researchers, including those with limited coding knowledge, with the necessary skills to enhance reproducibility in their work. It covers three essential components: version control using Git, dynamic document creation using rmarkdown, and managing R package dependencies with renv. The tutorial also provides insights into sharing reproducible research and offers specific considerations for the field of sleep and chronobiology research. By following the tutorial, researchers can adopt practices that enhance the transparency, rigor, and replicability of their work, contributing to a culture of reproducible research and advancing scientific knowledge.

The objective of the present study was to formulate and evaluate Effervescent Floating Tablet of Fluoxetine for the treatment of antidepressant agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid were used producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release by zero order, first order rate kinetics. No significant change was observed in physical appearance, drug content, floatability or in-vitro dissolution pattern after storage at 45°C/75°C RH for three months. [ABSTRACT FROM AUTHOR]

Background: Endoscopic biopsy are easy, less time consuming and OPD side procedure where no general anaesthesia is required or hospitalization is needed, is required for confirmation of diagnosis which is impossible by FNAC. Endoscopic biopsy permits the correct identification of lesion and taking out the biopsy from the same site. Objectives: 1. To study the spectra of various histopathological lesions in GIT with the help of endoscopic biopsy. 2. To prove endoscopic biopsies as an efficient tool for reaching correct diagnosis. Methodology - Cross sectional study will be carried out from August 2018 to August 2021 AVBRH Sawangi, Wardha, Maharashtra. Patients with gastrointestinal symptoms undergoing endoscopic / colonoscopic examination. The biopsy specimen will be processed and then will be paraffin embedded. Each section will be stained with Hematoxylin and Eosin as per standard protocol and studied microscopically. 100 endoscopic biopsies were examined during the study period. Expected Results – Results will be evaluated after the completion of the study using SPSS VERSION 21. Conclusion- The conclusion will be based on the results of study. [ABSTRACT FROM AUTHOR]

We generalize the notion of multi-Gieseker semistability for coherent sheaves, introduced by Greb, Ross, and Toma, to quiver sheaves for a quiver Q. We construct coarse moduli spaces for semistable quiver sheaves using a functorial method that realizes these as subschemes of moduli spaces of representations of a twisted quiver, depending on Q, with relations. We also show the projectivity of the moduli space in the case when Q has no oriented cycles. Further, we construct moduli spaces of quiver sheaves which satisfy a given set of relations as closed subvarieties. Finally, we investigate the parameter dependence of the moduli. [ABSTRACT FROM AUTHOR]

Abstract This work reports on a simple, fast and food-grade encapsulation approach with potential for probiotic protection, which consists on the formation of agarose-based hydrogel particles. These were generated by the supramolecular self-assembly of the probiotic-containing carbohydrate solutions by dripping them into a biphasic bath with an upper oil layer, which acted as the particle-forming antisolvent, and a lower aqueous layer, where the hydrogel particles were collected. This technique, which we have named "oil-induced biphasic hydrogel particle formation", has been used to encapsulate the sensitive strain Bifidobacterium pseudocatenulatum CECT 7765. In order to avoid agarose gelling at 40 °C before the encapsulation process, this seaweed-derived carbohydrate was combined with other hydrocolloids (alginate, whey protein concentrate, and gelatin), and the obtained probiotic-containing hydrogel particles were subsequently freeze-dried. The protection ability of this method versus directly freeze-drying the probiotic-containing solutions was demonstrated during storage and simulated in-vitro digestion. Both the formation of a continuous layer surrounding the bacteria and the optimal combination of materials (agarose providing suitable oxygen barrier and WPC with proven probiotic affinity) rendered encapsulation systems keeping viability levels required for commercial applications. Graphical abstract Image 1 Highlights • Agarose-based blends were developed as encapsulating systems for probiotics. • Hydrogel particles were formed through a newly developed process. • Encapsulation prior to freeze-drying resulted in improved probiotic protection. • This strategy efficiently protected the sensitive bacteria through in-vitro digestion. [ABSTRACT FROM AUTHOR]

Abstract Wide bandgap (WBG) semiconductor devices represent an attractive developing technology for power applications that is recently gaining commercial ground. GaN has advantages as one of the top contenders with high bandgap, high mobility, high saturation velocity, and high breakdown voltage. GaN enhancement-mode devices are favored over depletion-mode devices for power electronics applications and are only recently becoming commercially available. The enhancement-mode device investigated in this work is a GaN-gate injection transistor (GIT) in which the normally-off operation is achieved with an additional p -doped gate. This paper presents current-voltage (I-V) characteristics of GaN-GIT device using a physics based compact model as well as TCAD (Technology Computer-Aided Design) numerical simulation to predict and model the device behavior of the GIT. This paper presents a comparison of the TCAD simulation results with a compact model intended for low frequency applications in power electronics in the KHz to MHz range. [ABSTRACT FROM AUTHOR]

Abstract The World Wide Web and the Semantic Web are designed as a network of distributed services and datasets. The distributed character of the Web brings manifold collaborative possibilities to interchange data. The commonly adopted collaborative solutions for RDF data are centralized (e. g. SPARQL endpoints and wiki systems). But to support distributed collaboration, a system is needed, that supports divergence of datasets, brings the possibility to conflate diverged states , and allows distributed datasets to be synchronized. In this paper, we present Quit Store , it was inspired by and it builds upon the successful Git system. The approach is based on a formal expression of evolution and consolidation of distributed datasets. During the collaborative curation process, the system automatically versions the RDF dataset and tracks provenance information. It also provides support to branch, merge, and synchronize distributed RDF datasets. The merging process is guarded by specific merge strategies for RDF data. Finally, we use our reference implementation to show overall good performance and demonstrate the practical usability of the system. [ABSTRACT FROM AUTHOR]

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Abstract Silymarin, the standardized extract from the milk thistle (Silybum marianum), is composed mostly of flavonolignans and is approved in the EU for the adjuvant therapy of alcoholic liver disease. It is also used for other purported effects in miscellaneous nutraceuticals. Due to polyhydroxylated structures and low systemic bioavailability, these flavonolignans are likely to interact with transition metals in the gastrointestinal tract. The aim of this study was to analyze the interactions of pure silymarin flavonolignans with copper and iron. Both competitive and non-competitive methods at various physiologically relevant pH levels ranging from 4.5 to 7.5 were tested. Only 2,3‑dehydrosilybin was found to be a potent or moderately active iron and copper chelator. Silybin A, silybin B and silychristin A were less potent or inactive chelators. Both 2,3‑dehydrosilybin enantiomers (A and B) were equally active iron and copper chelators, and the preferred stoichiometries were mainly 2:1 and 3:1 (2,3‑dehydrosilybin:metal). Additional experiments showed that silychristin was the most potent iron and copper reductant. Comparison with their structural precursors taxifolin and quercetin is included as well. Based on these results, silymarin administration most probably affects the kinetics of copper and iron in the gastrointestinal tract, however, due to the different interactions of individual components of silymarin with these transition metals, the biological effects need to be evaluated in the future in a much more complex study. Graphical abstract Structure-activity relationship in the group of the tested flavonolignans - the influence of the chemical structure on iron/copper chelation and copper reduction. Unlabelled Image Highlights • Silymarin is a mixture of flavonolignans and other phenolic compounds. • Pure flavonolignans were tested on interactions with iron and copper. • 2,3‑Dehydrosilybin was the most potent metal chelator. • Both enantiomers formed complexes 2:1 or 3:1 (flavonolignan to metal) in most conditions. • Silychristin A was the most potent metal reducing agent. [ABSTRACT FROM AUTHOR]

Open Source Hardware (OSH) is an increasingly viable approach to intellectual property management extending the principles of Open Source Software (OSS) to the domain of physical products. These principles support the development of products in transparent processes allowing the participation of any interested person. While increasing numbers of products have been released as OSH, little is known on the prevalence of participative development practices in this emerging field. It remains unclear to which extent the transparent and participatory processes known from software reached hardware product development. To fill this gap, this paper applies repository mining techniques to investigate the transparency andworkload distribution of 105 OSHproduct development projects. The results highlight a certain heterogeneity of practices filling a continuum between public and private development settings. They reveal different organizational patterns with different levels of centralization and distribution. Nonetheless, they clearly indicate the expansion of the open source development model from software into the realms of physical products and provide the first large-scale empirical evidence of this recent evolution. Therewith, this article gives body to an emerging phenomenon and contributes to give it a place in the scientific debate. It delivers categories to delineate practices, techniques to investigate them in further detail aswell as a large dataset of exemplary OSHprojects. The discussion of first results signposts avenues for a stream of research aiming at understanding stakeholder interactions at work in new product innovation practices in order to enable institutions and industry in providing appropriate responses. [ABSTRACT FROM AUTHOR]

Enterococci are important bacterial pathogens, and their significance is even greater in the case of vancomycin-resistant enterococci (VRE). The study analyzed the presence of VRE in the gastrointestinal tract (GIT) of hemato-oncological patients. Active screening using selective agars yielded VRE for phenotypic and genotypic analyses. Isolated strains were identified with MALDI-TOF MS, (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry) their susceptibility to antibiotics was tested, and resistance genes (vanA, vanB, vanC-1, vanC2-C3) and genes encoding virulence factors (asa1, gelE, cylA, esp, hyl) were detected. Pulsed-field gel electrophoresis was used to assess the relationship of the isolated strains. Over a period of three years, 103 VanA-type VRE were identified in 1405 hemato-oncological patients. The most frequently detected virulence factor was extracellular surface protein (84%), followed by hyaluronidase (40%). Unique restriction profiles were observed in 33% of strains; clonality was detected in 67% of isolates. The study found that 7% of hemato-oncological patients carried VRE in their GIT. In all cases, the species identified was Enterococcus faecium. No clone persisted for the entire 3-year study period. However, genetically different clusters were observed for shorter periods of time, no longer than eight months, with identical VRE spreading among patients.

В статье рассмотрен опыт формулирования требований, проектирования и разработки кафедральной системы управления обучением для ИТ-образования в МГТУ им Н. Э. Баумана. Система решает задачи автоматизации специфичных для ИТ-образования процессов на основе профессиональных инструментов, таких как системы контроля версий. Такой подход не только позволяет решить задачу автоматизации, но и подготавливает студентов к будущей профессиональной деятельности.

Gastrointestinal microbiota play an important role in regulating the metabolic processes of animals and humans. A properly balanced cecal microbiota modulates growth parameters and the risk of infections. The study examined the effect of the addition of 0.2% and 0.3% of Tenebrio molitor and Zophobas morio on cecal microbiome of broilers. The material was the cecum digesta. The obtained DNA was analyzed using 16S rRNA next generation sequencing. The results of the study show that the addition of a relatively small amount of Z. morio and T. molitor modulates the broiler cecum microbiome composition. The most positive effect on cecal microbiota was recorded in the 0.2% Z. morio diet. A significant increase in the relative amount of genus Lactobacillus, represented by the species Lactobacillus agilis and the amount of bacteria in the Clostridia class, was observed. Moreover, the addition of 0.2% ZM resulted in a significant increase of relative abundance of the family Bifidobacteriaceae with the highest relative abundance of genus Bifidobacterium pseudolongum. The obtained results indicate that the addition of a relatively small amount of insect meal in broiler diet stimulates colonization by probiotic and commensal bacteria, which may act as barriers against infection by pathogenic bacteria.

The present study explored the possible prebiotic application of potato peel and bamboo shoot extracts for the proliferation of lactic acid bacteria (LAB) from diverse niches and their tolerance ability to simulated gastrointestinal tract (GIT) conditions was also examined. Initially, the complete 16S rDNA sequencing of selected isolates revealed them as Lactobacillus paracasei (6), Staphylococcus simulans (2), and Streptococcus thermophilus (1). Higher cell densities and rapid pH change were obtained from cultured media supplemented with BS (2%) and PP (2%) as a carbon source. Their higher tolerance and the lowest reducing sugar abilities were obtained for BS at pH 2.5 and 9.0, while at pH 3.5 and 8.0 for PP. The isolates were screened for additional functional and technological properties to harvest the most appropriate starter. The selected isolates harbored promising functional properties such as amylase presence, cell surface hydrophobicity, autoaggregation, proteolytic and lipolytic activity, antifungal action, as well as exopolysaccharide production. On the basis of these attributes, microencapsulated strain K3 was found resistant to gastrointestinal conditions after 2 h, resulting in significantly (p ≤ 0.05) improved survival compared to non-capsulated strain. The current approach presents an interesting economical strategy to modulate LAB through supplementation of plant-derived carbon sources as well as to enhance their survival under GIT.

Open Source Hardware (OSH) is an increasingly viable approach to intellectual property management extending the principles of Open Source Software (OSS) to the domain of physical products. These principles support the development of products in transparent processes allowing the participation of any interested person. While increasing numbers of products have been released as OSH, little is known on the prevalence of participative development practices in this emerging field. It remains unclear to which extent the transparent and participatory processes known from software reached hardware product development. To fill this gap, this paper applies repository mining techniques to investigate the transparency and workload distribution of 105 OSH product development projects. The results highlight a certain heterogeneity of practices filling a continuum between public and private development settings. They reveal different organizational patterns with different levels of centralization and distribution. Nonetheless, they clearly indicate the expansion of the open source development model from software into the realms of physical products and provide the first large-scale empirical evidence of this recent evolution. Therewith, this article gives body to an emerging phenomenon and contributes to give it a place in the scientific debate. It delivers categories to delineate practices, techniques to investigate them in further detail as well as a large dataset of exemplary OSH projects. The discussion of first results signposts avenues for a stream of research aiming at understanding stakeholder interactions at work in new product innovation practices in order to enable institutions and industry in providing appropriate responses.

Background Software maintenance is an important activity in the development process where maintenance team members leave and new members join over time. The identification of files which are changed together frequently has been proposed several times. Yet, existing studies about coupled file changes ignore the feedback from developers as well as the impact of these changes on the performance of maintenance and rather these studies rely on the analysis findings and expert evaluation. Methods We investigate the usefulness of coupled file changes during perfective maintenance tasks when developers are inexperienced in programming or when they were new on the project. Using data mining on software repositories we identify files that are changed most frequently together in the past. We extract coupled file changes from the Git repository of a Java software system and join them with corresponding attributes from the versioning and issue tracking system and the project documentation. We present a controlled experiment involving 36 student participants in which we investigate if coupled file change suggestions influence the correctness of the task solutions and the required time to complete them. Results The results show that the use of coupled file change suggestions significantly increases the correctness of the solutions. However, there is only a minor effect on the time required to complete the perfective maintenance tasks. We also derived a set of the most useful attributes based on the developers’ feedback. Discussion Coupled file changes and a limited number of the proposed attributes are useful for inexperienced developers working on perfective maintenance tasks where although the developers using these suggestions solved more tasks, they still need time to understand and organize this information.