Search

Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development. [ABSTRACT FROM AUTHOR]

Maternal transfer of fatty acids is important to fetal brain development. The prenatal environment may differentially affect the substrates supporting declarative memory abilities, as the level of fatty acids transferred across the placenta may be affected by the maternal fatty acid desaturase 2 ( FADS2 ) rs174575 single nucleotide polymorphism. In this study, we hypothesized that toddler and maternal rs174575 genotype and FADS2 promoter methylation would be related to the toddlers’ declarative memory performance. Seventy-one 16-month-old toddlers participated in an imitation paradigm designed to test immediate and long-term declarative memory abilities. FADS2 rs174575 genotype was determined and FADS2 promoter methylation was quantified from blood by bisulfite pyrosequencing for the toddlers and their natural mothers. Toddlers of GG mothers at the FADS2 rs174575 single nucleotide polymorphism did not perform as well on memory assessments as toddlers of CC or CG mothers when controlling for plasma α -linolenic acid and child genotype. Toddler methylation status was related to immediate memory performance, whereas maternal methylation status was related to delayed memory performance. Thus, prenatal experience and maternal FADS2 status have a pervasive, long-lasting influence on the brain development of the offspring, but as the postnatal environment becomes more primary, the offsprings’ own biology begins to have an effect. [ABSTRACT FROM AUTHOR]

Modern commercial fisheries are heavily dependent on the input of fossil fuels throughout their supply chains, particularly diesel inputs to fishing vessels. Fuel use intensity of fisheries varies with regard to target species, gears employed, region of fishing, technologies used, skipper behaviour, and other factors. Those fisheries that consume relatively less fuel not only have a lower carbon footprint, up to the point of landing, but are also in a favourable position to meet future fuel and emissions regulations, and may be more resilient to the effects of volatile fuel prices and limited oil resources. We measured fuel inputs to purse seining vessels targeting primarily skipjack ( Katsuwonus pelamis ) and yellowfin ( Thunnus albacores ) tuna. Data reported represent 28% of worldwide landings of skipjack and yellowfin by purse seiners in 2009. These vessels burned, on average, 368 L of fuel per tonne of wet weight landings. This corresponds to a fuel-related carbon footprint of 1.1 kg CO 2 per landed kg of tuna, lower than that of average marine capture fisheries as well as most forms of land-based animal protein production. Interestingly, the use of FADs in purse seine fisheries for tuna was found to be inversely correlated with efficiency, going against conventional logic that FAD use improves efficiency. This study is the largest snapshot of tuna fuel inputs to date, providing a baseline against which future performance can be measured, and an indicator for consumers concerned about the carbon footprint of their food choices. [ABSTRACT FROM AUTHOR]

Background/Aims: Long-chain polyunsaturated fatty acids (LC-PUFA) are regarded as essential for child cognition. Genetic variation in fatty acid (FA) desaturase enzyme (FADS) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function. This study aimed to identify the distribution of genetic variant (genotype) SNP rs174468 and to assess plasma FA and developmental outcome by the genotype among under-2 year old Sasaknese Indonesian children. Methods: Data was collected at baseline of a randomized trial (NUPICO, clinicaltrials.gov NCT01504633) in East Lombok district, Indonesia. Breastfed, 12-17 month old children were recruited and 240 subjects were included in the study. Child cognition was assessed as Bayley Mental Developmental Index (MDI). Results: From 206 subjects whose blood samples can be collected, only two genotypes were found (90.3% GG homozygotes, 9.7% AG heterozygotes), and minor allele AG was significantly associated with higher level of arachidonic acid (20:4 n-6), n-6 LC-PUFA and FADS1 index. MDI score was associated with a FADS2 index (DHA:EPA ratio) but not genotype (Adjusted R-square= 0.043). Conclusions: FADS2 index was associated with cognitive function. No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to propose that adoption of new ideas is a more involved cognitive process than has been recognised and this paper seeks to redress the trivialisation of ideas as emerging management ideas (“fads”). The embracing of “fads” for performance improvement and competitive advantage has received considerable attention in the academic literature, resulting in a rather one-sided view. Design/methodology/approach – Cognitive decision-making, evidence-based management and complexity theory are examined to illustrate cognitive process, skills and experiences used when making decisions and several propositions are derived from these ideas. Findings – An conceptual model of “fad” adoption, integrating the ideas and propositions is presented. This model provides a more pragmatic examination of “fad” adoption decisions and encourages an in depth consideration of their introduction. The model offers a more sophisticated, focused tool for examining the adoption of new management ideas and provides a springboard from which more detailed, integrated models can be developed, and hopefully will stimulate discussion. Implications for theory and practice are also considered. Originality/value – Examination of the literature on management “fads” revealed significant material that focused on the negative aspects of “fad” adoption, but an absence of material that examined how manager’s made their adoption decisions. This paper, therefore, provides a valuable contribution to both theory and practice by examining factors which contribute to how and why management decisions to adopt “fads” are made and develops a model to illustrate how these are integrated to contribute to the process of decision-making. [ABSTRACT FROM AUTHOR]

In the 1890s British women witnessed a 'cycling craze' that had the potential to enhance the health and physical freedom of many women. This article examines the cycling craze from a Scottish perspective by investigating representations of Scottish female cyclists in a weekly magazine first printed in Glasgow in 1888 entitled The Scottish Cyclist. Despite suggestions that the popularity of cycling faltered after the initial 'cycling-craze' of the mid-1890s, perusal of The Scottish Cyclist suggests that a number of Scottish women continued to cycle beyond the years of this initial craze, thus eventually helping to make the cycling woman a familiar sight in Scottish society. This article argues that whilst by 1914 the cycling woman clad in 'rational dress' was no longer a key symbol of emancipation, still the determination of female cyclists in Scotland had contributed to the physical emancipation of women, giving them access to greater independence, mobility, and physical freedom. [ABSTRACT FROM AUTHOR]

Morphological selection techniques of gametes and embryos are of current interest to clinical practice in ART. Although intracytoplasmic morphologically selected sperm injection (IMSI), time lapse imaging morphometry (TLIM) or quantification of chromosome numbers (PGS) are potentially useful in research, they have not been shown to be of statistically predictive value and, thus, have only limited clinical usefulness. We make the point that morphological markers alone cannot predict the success of the early embryo, which depends on the correct orchestration of a myriad of physiological and biochemical activation events that progress independently of the maternal or zygotic genome. Since previous attempts to identify metabolic markers for embryo quality have failed and there is no evidence that the intrinsic nature of gametes and embryos can be improved in the laboratory, embryologists can only minimize environmental or operator induced damage while these cells are manipulated ex vivo. [ABSTRACT FROM AUTHOR]

Most studies of fashion and fads focus on objects and practices that once were popular. We argue that limiting the sample to such trajectories generates a selection bias that obscures the underlying process and generates biased estimates. Through simulations and the analysis of a data set that has previously not been used to analyze the rise and fall of cultural practices, the New York Times text archive, we show that studying a whole range of cultural objects, both popular and less popular, is essential for understanding the drivers of popularity. In particular, we show that estimates of statistical models of the drivers of popularity will be biased if researchers use only trajectories of those practices that once were popular. [ABSTRACT FROM AUTHOR]

Scholarship in urban sociology has pointed to the reliance of city governments on ever-more market mechanisms for organizing social and economic policy. This form of governance involves prioritizing cities' cultural and social assets for their value in a global competition of urban 'brands,' each competing for new infusions of human and investment capital. At the same time, however, cities have been at the center of seemingly progressive policy efforts aimed at promoting innovation, sustainability, and creativity. These themes represent a newly dominant planning discourse in cities across the globe. While researchers have thoroughly examined how 'creative classes' and 'creative cities' may exclude everyday, working-class, or poor residents, new urban imaginaries focused on sustainability potentially imply less stratified urban outcomes. Analyzing two high-profile interventions in Buenos Aires, Argentina-a sustainable urban regeneration plan for the historic downtown, and the creation of an arts cluster in the impoverished south of the city-this paper argues that despite divergent narratives, creative and sustainable urban projects suggest similar policy agendas, planning assumptions, and relationships to market mechanisms. Increasingly, global policies, whose design and objectives may appear to contradict market logics, may have outcomes that further them. [ABSTRACT FROM AUTHOR]

Based on the commercial surrounding nets traditionally used in the Coryphaena hippurus fishery, we designed an experimental purse seine (64 m long and 14 m high, with a purse line and a central codend of 2 mm mesh) for sampling fish fauna associated with flotsam. Taxa, number, biomass and sizes of fishes caught with both types of gear around fish aggregation devices were compared. From 63 hauls with the experimental net, we caught 11370 fishes belonging to 17 families and 26 species. In contrast, 816 fishes belonging to 7 species and 5 families were collected from 39 commercial hauls. Despite differences in number of hauls for each net, the curves of cumulative species richness showed that additional hauls could not increase the number of species collected with the commercial net. The most abundant species from experimental net catches were Trachurus picturatus, which represented over 80% of the specimens caught in spring and summer, Naucrates ductor, which represented about 50% of autumn catches, both in terms of abundance and biomass, and Seriola dumerili, which represented 46% and 21% of the samples taken in summer and autumn respectively. Seriola dumerili was also frequent in commercial net catches, in which T. picturatus did not appear, while Coryphaena hippurus and N. ductor represented more than 85% of both abundance and biomass. Large differences between the two types of net were also obtained in the mean fish weight and length frequency distributions of the catches by season. Fish caught with the experimental net ranged from 6 to 570 mm length, while fish collected from commercial hauls had a size range of 35 to 700 mm. The effectiveness of the experimental net in catching small fishes showed that it can be an optimal sampling method not only in the study of fish fauna associated with flotsam, but also in studies to catch early life stages.

The dolphinfish (Coryphaena hippurus) fishery based on the island of Majorca (western Mediterranean) and the population dynamics of the species were studied between 1995 and 1996. Fishing effort, landings and length composition of the catches during the sampling period, as well as the historic catch data series and fleet were analysed. Virtual Population Analysis (VPA), taking as the time unit the week in 1995 and the fortnight in 1996, were also carried out. Dolphinfish is fished from August to December, with main catches in September-October, using anchored fish aggregation devices (FADs) and surrounding net. The mooring areas, placed from 70 to 1200 m depth, are distributed among the boats registered for the year´s fishery. A total of 46 boats took part in this fishery in 1995 and 37 in 1996, with a catch of 128 and 52 metric tons respectively. These wide fluctuations are also shown in the annual catches of the 16year series, which ranged from 2 to more than 120 metric tons, showing a slightly increasing trend (4 tons per year). The comparison of different measures of effort (FADs, days and hours) showed similar values of CPUE, although the number of FADs showed the lowest variation, with normal variances and average values not significantly different between harbours. The length composition of the catches ranged from 20 to 64 cm fork length, which corresponds to juveniles between 2 and 6 months of age. The main results of the VPA, which must be regarded in relative rather than absolute values, showed that the available population and the recruitment in 1995 are greater (around one order of magnitude) than in 1996. For both years, the number of individuals declined in the course of the fishing season, while biomass increased during the first 5 weeks. The fact that the exploited fraction of the dolphinfish population is composed of 0-age class suggests that catch fluctuations might be related to environmental parameters and to the migratory behaviour pattern of the species. These two interrelated factors can produce failures of its annual spawning in the western Mediterranean, and/or of the recruitment of the species to the fishery.

In 1996, a census was taken of the Sicilian fisheries that engage in dolphinfish (Coryphaena hippurus L. 1758) fishing. Two different surveys were conducted; data on fishing boats were obtained from the Naval Registers and frominterviewing boat owners on the wharf. The area sampled was divided into 3 zones and 6 strata. 205 boats were recorded in the eastern zone (Tyrrhenian and Ionian seas), 57 boats located in 4 different strata were recorded in the western zone. Fishing activities in the Ionian area begin in early August and end in December. In all other areas of Sicily, dolphinfish fishing begins in early September and continues until December. A census was also taken of the equipment used by the various boats for this activity in the different areas. The surveys showed that FADs are the most commonly employed method for dolphinfish fishing. The geographical distribution, number and characteristics were recorded for each area surveyed. The catches for the 1996 fishing season distributed for strata and zone are reported.

There is widespread use of fish attraction devices (FADs) in commercial fisheries and research. Investigations on the utility of FADs to catch fishes, and factors influencing fishes associated with FADs, require careful consideration of experimental designs. The development of appropriate models, from observations and the literature, should be developed before hypotheses can be tested with robust sampling designs. Robust sampling designs may only be possible if investigators have some role in the planning stage of deploying FADs. If the objective of the study is to determine the influence of FADs on assemblages of fishes, then experimenters need to consider that a `FAD-effect´ (=impact) cannot be demonstrated without controls. Some preliminary studies may be required to determine the spatial extent of a FAD-effect before suitable sites can be chosen for controls. Other controls may also be necessary, depending on the method used to estimate numbers of fishes (e.g. controls for disturbance). Recent advances in sampling designs that are applicable to impact studies are discussed. Beyond-BACI (Before After Control Impact) and MBACI (Multiple BACI) designs are recommended because they cater for temporal and spatial variation in the abundance of organisms, which is generally great for pelagic fishes. The utility of orthogonal sampling designs is emphasised as a means of elucidating the influence of multiple factors and, importantly, interactions between them. Further, nested analyses are suggested to deal with multiple temporal and/or spatial time scales in sampling designs. The independence of replicate FADs should also be considered. Problems of independence include: FADs that are connected, thus providing potential routes of movement of associated fishes; temporal dependence where the number of fish at a time influences the number at the next time due to fish becoming residents; and the fact that the proximity of other FADs may influence numbers of fishes. Solutions to these problems are suggested. The recommendations in this paper are relevant to investigations on pelagic fish of all sizes, with and without FADs.

Floating fish aggregating devices (FADs) have long been used to attract fish in NW Sicily since antiquity. Recently, a number of changes have been made to the type of material employed to construct FADs, with the aim of increasing their effectiveness. In this paper we compare the catches made at eight experimental floating FADs (polypropylene ropes frayed at the ends) with those obtained at eight traditional FADs in the Gulf of Castellammare. A total of 672 samples were collected during summer and autumn in 1995 and 1996 at the 16 FADs using a surrounding net. Visual observations of fishes associated with the FADs were also conducted to obtain qualitative information about the spatial distribution of species. A total of 1632 specimens weighing 144 kg and belonging to eight species were caught during the survey. Seriola dumerili, Caranx crysos, C. rhonchus and Coryphaena hippurus were the most frequent and abundant species accounting for 96% of the total catch. Average fish abundance and weight, characterised by high variance, were significantly higher at the sites with experimental FADs than at the sites with traditional FADs. S. dumerili was the only species with higher catches around the experimental FADs. Some spatial and temporal variations in fish abundance and size were also detected. Younger individuals of S. dumerili were observed to show high affinity for the experimental FAD tufts.

Sixteen fish aggregation devices (FADs) were deployed in 50 to 500 m deep of water in the Canary Islands. Species composition and abundance were determined by visual census carried out by divers on 55 occasions from April to October 1995 and from August 1996 to May 1997. A total of 15 species representing nine families of fish were observed. Pseudocaranx dentex (Bloch and Schneider, 1810), Seriola spp. and Naucrates ductor (Linnaeus, 1758) were the most abundant species. The number of species associated with FADs increased with immersion time, but fish biomass did not increase. The maximum number of fish species registered exactly under the FADs at any one time was five. The average estimated biomass was 9.47 Kg per FAD (SD= 25.2). However, when only baitfish were taken into account, the mean aggregated fish biomass was 3.20 Kg (SD= 4.32). The estimated biomass was higher when Coryphaena spp. was present, increasing to 53.9 Kg per FAD (SD=53.6). A significantly lower fish biomass and number of species was observed in FADs deployed in shallower waters (50-100 m depth).

Two groups of six fish aggregating devices (FADs) were deployed at two locations off the eastern coast of Majorca (Western Mediterranean). Samples were obtained fortnightly throughout a two-year period by means of hauls performed with an experimental purse seine. Two control areas were established to check the aggregation efficiency of the FADs. A total of 16 families and 26 species of fishes were recorded beneath FADs. Pelagic fishes, largely Trachurus picturatus, T. mediterraneus, T. trachurus, Naucrates ductor, Seriola dumerili and Coryphaena hippurus, dominated the fauna. The total fish abundance, number of species and length range of the species confirmed that the FAD community was significantly related to season (recruitment period), resulting in a sequential fish colonisation of the FADs during the study period. Some of the species were present only during a particular period, such as Trachurus spp. in spring and summer. Other species, although evident for a longer period, were more occasional in catches (Schedophilus ovalis, Balistes carolinensis and Polyprion americanus), and some others were also present in small quantities. Diversity and equitability of the fish community associated with FADs were higher in summer than in winter. Many species were more abundant around FADs than in open water controls. The species that showed the most distinct recruitment phase beneath the FADs were N. ductor, S. ovalis, Trachurus spp., P. americanus, S. dumerili, C. hippurus and B. carolinensis. FADs can be considered nursery structures for many pelagic and demersal species, thus having an effect on the redistribution of juveniles. In the deployment of artificial structures as aggregators for fishing purposes one should consider the patchiness and seasonal characteristics of these communities as well as the redistribution aspect for fishery management.

What accounts for the spread of Sovereign Wealth Funds ( SWFs)? Despite the increasing importance of SWFs in the global economy, we lack persuasive systematic answers to that question. Most analysts take for granted that economic imperatives drive the creation of SWFs; governments create them as effective solutions to the challenges generated by reserve accumulation and commodity-export specialization. In this article, I argue that the evidence fails to support this theory. Instead, the spread of SWFs best resembles the diffusion of a fashion or fad. SWFs became fashionable as an appropriate approach for reserve- and resource-rich countries seeking to manage policy uncertainty related to these economic characteristics. As other countries developed the same characteristics, they followed the lead of their peers and also created SWFs. I provide, with the use of a new data set, the first cross-national political-economy statistical analysis of SWF creation. The results suggest peer group emulation has, indeed, been crucial in shaping the decision of many countries to create SWFs-especially in fuel-exporting countries. [ABSTRACT FROM AUTHOR]

This article probes the cultural meaning of contemporary meme genres that are based on photographs. The analysis looks into the broad dimensions of truth and temporality, as expressed in three prominent genres: reaction Photoshops, stock character macros, and photo fads. Based on patterns shared by these genres, it is argued that photo-based memes function as both modes of hypersignification, wherein the code itself becomes the focus of attention, and as prospective photography, wherein photos are increasingly perceived as the raw material for future images. Finally, combining the two frames, memes are conceptualized as operative signs – textual categories that are designed as invitations for (creative) action. While these three qualities were also evident, in one way or another, in traditional forms of photography, they have emerged as governing logics in an era marked by an amalgamation of digital photography and participatory culture. [ABSTRACT FROM PUBLISHER]

Total lipid content and lipid class composition were analyzed in gonads, liver and white muscle of yellowfin tuna (Thunnus albacares) throughout ovary development to understand its reproductive allocation strategy and to assess the relation between female condition and reproduction. A total of 112 females were collected onboard purse-seiner in the Western Indian Ocean from January to March 2009, from June to July 2009, and from April to May 2010. Gonads were characterized by highly variable total lipid contents ranging from 5 to 27μgmg-1 of wet weight (ww) with a predominance of neutral lipids, mainly triacylglycerols (TAG) and sterol- and wax-esters. The different lipid classes in gonads described an accumulative pattern through the maturity process from immature to hydration phase. Total lipid content in liver varied from 10 to 21μgmg-1 ww, and serves as fuel for yellowfin tuna reproduction. TAG and phospholipid deposits became depleted as the ovary developed, suggesting a transfer of lipids directly from liver to the oocytes during vitellogenesis. In contrast, muscle total lipid content was low and constant throughout ovarian development (2.5-6μgmg-1 ww). Hence, yellowfin tuna can be defined as an income-capital breeder species for which the cost of reproduction depends mainly on concurrent energy income from feeding and only little on stored lipids. Besides, no significant relationship between gonad lipid composition and fecundity was found in females able to spawn. Finally, the influence of yellowfin tuna aggregation behaviour on reproductive female condition has been investigated: gonad total lipid contents were higher in females caught in free-swimming schools than in females caught under fish aggregating devices (FADs). However, these results did not clarify whether the influence of FADs on associated yellowfin tuna affects their reproductive capacity. [ABSTRACT FROM AUTHOR]

Parents of nonspeaking children with autism are vulnerable to treatments that promise them a whole, normal child hidden within the nonspeaking child. Facilitated communication (FC) and the rapid prompting method (RPM) have, despite being debunked, flourished in the last decade, due to the ability of the internet to connect parents with individuals who are being facilitated and display eloquent, even advanced communication skills. In order for the medical, psychological, and education fields to effectively combat the rise in FC and RPM, a revolution in the way parents are informed and educated is essential. Parents need training in proven methods and in how to spot fad treatments that offer no evidence of efficacy. To that end it would be helpful to hear from parents who once bought into the debunked treatment, as well as from professionals. [ABSTRACT FROM AUTHOR]

Social learning in chimpanzees has been studied extensively and it is now widely accepted that chimpanzees have the capacity to learn from conspecifics through a multitude of mechanisms. Very few studies, however, have documented the existence of spontaneously emerged traditions in chimpanzee communities. While the rigour of experimental studies is helpful to investigate social learning mechanisms, documentation of naturally occurring traditions is necessary to understand the relevance of social learning in the real lives of animals. In this study, we report on chimpanzees spontaneously copying a seemingly non-adaptive behaviour ('grass-in-ear behaviour'). The behaviour entailed chimpanzees selecting a stiff, straw-like blade of grass, inserting the grass into one of their own ears, adjusting the position, and then leaving it in their ear during subsequent activities. Using a daily focal follow procedure, over the course of 1 year, we observed 8 (out of 12) group members engaging in this peculiar behaviour. Importantly, in the three neighbouring groups of chimpanzees ( n = 82), this behaviour was only observed once, indicating that ecological factors were not determiners of the prevalence of this behaviour. These observations show that chimpanzees have a tendency to copy each other's behaviour, even when the adaptive value of the behaviour is presumably absent. [ABSTRACT FROM AUTHOR]

The article discusses several aspects of urban farming in relation to distressed cities in places such as the U.S., and it mentions various fads and social and cultural movements in America. Victory Gardens and the production of agricultural goods are mentioned, along with organic farming and local food movements across the U.S. Other topics include farmers' markets, environmental movements, and sustainable development in America.

Despite the overwhelming research evidence discrediting the validity of Facilitated Communication (FC), Lilienfeld, Marshall, Todd and Shane (2015) have demonstrated that the use of FC is still prevalent in disability service and educational settings. They have comprehensively examined the persistence of FC, provided reasons for its persistence, and formulated key recommendations to address the insidious spread of FC. We concur with Lilienfeld et al. as depressing as it may be, particularly regarding the continued use of FC by clinicians, educators and researchers. Drawing upon our experience as practitioners in the field of intellectual and developmental disability, we offer the view that it is important to argue against FC from a human rights perspective using the United NationsConvention on the Rights of Persons with Disabilities(2006). Put simply, FC is an abuse of human rights. [ABSTRACT FROM PUBLISHER]

Dramatic shifts in theWesterndiet have led to amarkedincrease in the dietary intake of the n-6 polyunsaturated fatty acid (PUFA), linoleic acid (LA). DietaryLAcan then be converted to arachidonic acid (ARA) utilizing three enzymatic steps. Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) and certain genetic variants within the cluster are highly associated withARAlevels.However,nostudy to date has examined whether these variants further influence pro-inflammatory, cyclooxygenase and lipoxygenase eicosanoid products. This study examined the impact of a highly influential FADS SNP, rs174537 on leukotriene, HETE, prostaglandin, and thromboxane biosynthesis in stimulated whole blood. Thirty subjects were genotyped at rs174537 (GG, n = 11; GT, n = 13; TT, n = 6), a panel of fatty acidsfromwholeserumwasanalyzed,andprecursor-to-product PUFA ratios were calculated as a marker of the capacity of tissues (particularly the liver) to synthesize long chain PUFAs. Eicosanoids produced by stimulated human blood were measured by LC-MS/MS.Weobservedanassociationbetweenrs174537andthe ratio of ARA/LA, leukotriene B4, and 5-HETE but no effect on levels of cyclooxygenase products. Our results suggest that variation at rs174537 not only impacts the synthesis of ARA but the overall capacity of whole blood to synthesize 5-lipoxygenase products; these genotype-related changes in eicosanoid levels could have important implications in a variety of inflammatory diseases. [ABSTRACT FROM AUTHOR]

Communication disorder and mental health professionals may assume that once novel clinical techniques have been refuted by research, they will be promptly abandoned. Using facilitated communication (FC) for autism as a recent case example, we provide evidence to the contrary. Although FC was scientifically discredited by the mid-to-late 1990s, data we review demonstrate that it is still frequently administered in clinical and educational settings. We examine evidence for FC’s (a) continued use as an intervention for autism, (b) persistence in academic and institutional settings, (c) popularity in online and print sources, (d) promotion in the media, and (e) ongoing risk to caregivers accused of sexual abuse. We analyze the sources of these troubling developments, explore their ethical implications, and offer recommendations for addressing the spread of FC and other fad interventions. [ABSTRACT FROM AUTHOR]

In 1836, American actor Thomas D. Rice first arrived in Great Britain to tour the creation that had made him famous in the USA, Jim Crow. This blackface depiction of a raggedy, runaway slave, with his infectious songs, eccentric dancing and demotic appeal soon took London by storm. The Jim Crow craze lasted for three years, with Rice finding fame, fortune and success and his imitators becoming ubiquitous in the capital's theatres and on its streets. Although the act and its character have been acknowledged as a precursor to the evolution of British minstrelsy and blackface traditions throughout the Victorian period, the craze itself has not been substantially studied in its British context. This essay will look beyond Rice's act and the performance of Jim Crow in the theatres to look instead at Jim Crow's appropriation in print satire and street performance. It will argue that these requisitions of Jim Crow illustrate how Georgian traditions of carnival and grotesque humour were redeveloped for the early Victorian context. In print, Jim Crow was widely utilized in caustic bodily humour that attacked insincere politicians. On the streets, this same humour was seen as obscene and was repressed and contained, paving the way for the respectable, mainstream Victorian blackface act. However, integral to both appropriations of Jim Crow was the figure of the black buffoon, and the act rapidly provided an archetype for the belittling and persecution of London's black population. [ABSTRACT FROM AUTHOR]

Abstract: Female humans and rodents have been shown to have higher 22:6n-3 status and synthesis than males. It is unclear which sex hormone is involved. We investigated the specificity of the effects of physiological concentrations of sex hormones in vitro on the mRNA expression of genes involved in polyunsaturated fatty acid (PUFA) biosynthesis and on the conversion of [d5]-18:3n-3 to longer chain fatty acids. Progesterone, but not 17α-ethynylestradiol or testosterone, increased FADS2, FADS1, ELOVl 5 and ELOVl 2 mRNA expression in HepG2 cells, but only FADS2 in primary human hepatocytes. In HepG2 cells, these changes were accompanied by hypomethylation of specific CpG loci in the FADS2 promoter. Progesterone, not 17α-ethynylestradiol or testosterone, increased conversion of [d5]-18:3n-3 to 20:5n-3, 22:5n-3 and 22:6n-3. These findings show that progesterone increases n-3 PUFA biosynthesis by up-regulating the mRNA expression of genes involved in this pathway, possibly via changes in the epigenetic regulation of FADS2. [Copyright &y& Elsevier]

This article addresses the music making of Korean Americans, focusing on their place within the emergent social media environment that has exploded in the last five years and comparing this with the very different environment of the previous decade. Biographical coverage of the careers of three Korean American musicians, two of whom have extensive social media presence, demonstrates how these media, particularly YouTube, represent a fundamental shift in the popular music profession, providing equalizing opportunities that are enabling some to circumvent racial barriers that have long existed and still persist in the major music and entertainment industries in the United States. [ABSTRACT FROM AUTHOR]