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668 results on '"Edland, Steven D."'

152. Potential implications of practice effects in Alzheimer's disease prevention trials

Author

Jacobs, Diane M., Ard, M. Colin, Salmon, David P., Galasko, Douglas R., Bondi, Mark W., and Edland, Steven D.

Abstract

Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of practice on trial outcome.

Published
2017
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153. Design of pilot studies to inform the construction of composite outcome measures

Author

Edland, Steven D., Ard, M. Colin, Li, Weiwei, and Jiang, Lingjing

Abstract

Composite scales have recently been proposed as outcome measures for clinical trials. For example, the Preclinical Alzheimer's Cognitive Composite (PACC) is the sum of z-score normed component measures assessing episodic memory, timed executive function, and global cognition. Alternative methods of calculating composite total scores using the weighted sum of the component measures that maximize the signal-to-noise ratio of the resulting composite score have been proposed. Optimal weights can be estimated from pilot data, but it is an open question how large a pilot trial is required to calculate reliably optimal weights.

Published
2017
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155. Imaging the Alzheimer Brain

Author

Ashford, J. Wesson, primary, Salehi, Ahmad, additional, Furst, Ansgar, additional, Bayley, Peter, additional, Frisoni, Giovanni B., additional, Jack Jr, Clifford R., additional, Sabri, Osama, additional, Adamson, Maheen M., additional, Coburn, Kerry L., additional, Olichney, John, additional, Schuff, Norbert, additional, Spielman, Daniel, additional, Edland, Steven D., additional, Black, Sandra, additional, Rosen, Allyson, additional, Kennedy, David, additional, Weiner, Michael, additional, and Perry, George, additional

Published
2011
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161. Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.

Author

Donohue, Michael C., Moghadam, Setareh H., Roe, Allyson D., Sun, Chung-Kai, Edland, Steven D., Thomas, Ronald G., Petersen, Ronald C., Sano, Mary, Galasko, Douglas, Aisen, Paul S., and Rissman, Robert A.

Abstract

Introduction Little is known about the utility of plasma amyloid beta (Aβ) in clinical trials of Alzheimer's disease (AD). Methods We analyzed longitudinal plasma samples from two large multicenter clinical trials: (1) donezepil and vitamin E in mild cognitive impairment (n = 405, 24 months) and (2) simvastatin in mild to moderate AD (n = 225, 18 months). Results Baseline plasma Aβ was not related to cognitive or clinical progression. We observed a decrease in plasma Aβ40 and 42 among apolipoprotein E epsilon 4 ( APOE ε4) carriers relative to noncarriers in the mild cognitive impairment trial. Patients treated with simvastatin showed a significant increase in Aβ compared with placebo. We found significant storage time effects and considerable plate-to-plate variation. Discussion We found no support for the utility of plasma Aβ as a prognostic factor or correlate of cognitive change. Analysis of stored specimens requires careful standardization and experimental design, but plasma Aβ may prove useful in pharmacodynamic studies of antiamyloid drugs. [ABSTRACT FROM AUTHOR]

Published
2015
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162. Smokers who report smoking but do not consider themselves smokers: a phenomenon in need of further attention.

Author

Leas, Eric C., Zablocki, Rong W., Edland, Steven D., and Al-Delaimy, Wael K.

Subjects
SMOKING & psychology, AGE distribution, CONFIDENCE intervals, MOTIVATION (Psychology), MULTIVARIATE analysis, SELF-perception, SEX distribution, SOCIAL stigma, SOCIAL attitudes, DATA analysis software, ODDS ratio
Abstract

Background Heightened stigma surrounding the action of smoking may decrease the likelihood that individuals who engage in smoking identify with the label 'smoker'. Non-identifying smokers (NIS) may undermine accurate smoking prevalence estimates and can be overlooked by tobacco control efforts. Objective We sought to characterise NIS in a cross-sectional study using a sample representative of the population of adults (>18 years) in California who reported smoking at least 100 cigarettes in their lifetime, smoking at least some days and at least once in the last 30 days (n=1698). Individuals were considered NIS if they met the above criteria and answered 'no' when asked if they 'considered themselves a smoker'. Results We estimate that 395 928 (SD=54 126) NIS were living in California in 2011 (a prevalence of 12.3% of all smokers in California). The odds of being NIS were higher among non-daily smokers who were previously daily smokers (adjusted OR (AOR)=7.63, 95% CI 2.67 to 21.8) or were never previously daily smokers (AOR=7.14, CI 2.78 to 18.3) compared with daily smokers. The odds of being an NIS were also higher among those who did not believe they were addicted to cigarettes (AOR=3.84, CI 1.68 to 9.22), were older than 65 years (vs less than 45 years) (AOR=3.35, CI 1.16 to 9.75) or were from ethnic minorities including Black and Asian (vs non-Hispanic white) (AOR=3.16, CI 1.19 to 8.49). Conclusions Smoking surveillance should restructure selection criteria to more accurately account for NIS in areas with high stigma toward smokers. Targeted interventions may be needed for NIS including educating healthcare providers to enquire more deeply into smoking habits. [ABSTRACT FROM AUTHOR]

Published
2015
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168. P1–206: The search for a successful cognitive aging endophenotype in the offspring of very elderly (90+) nondemented probands in a founder population

Author

Edland, Steven D., primary, Schnaider-Beeri, Michal, additional, Raventos, Henriette, additional, Aguilar, Daniel Valerio, additional, Corrales Campos, Luis Emilio, additional, Pereira Castro, Mariana, additional, Angelo, Gary W., additional, Grossman, Hillel T., additional, Bespalova, Irina N., additional, Sano, Mary, additional, and Silverman, Jeremy M., additional

Published
2006
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175. P2-185 Glucose metabolic patterns in amnestic mild cognitive impairment and Alzheimer's disease; an FDG pet study

Author

Kantarci, Kejal, primary, Kemp, Bradley J., additional, Lowe, Val J., additional, Petersen, Ronald C., additional, Boeve, Bradley F., additional, Knopman, David S., additional, Edland, Steven D., additional, Smith, Glenn E., additional, Ivnik, Robert J., additional, Tangalos, Eric G., additional, and Jack, Clifford R., additional

Published
2004
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180. Comparative Diagnostic Utility of Different MR Modalities in Mild Cognitive Impairment and Alzheimer’s Disease

Author

Kantarci, Kejal, primary, Xu, YueCheng, additional, Shiung, Maria M., additional, O’Brien, Peter C., additional, Cha, Ruth H., additional, Smith, Glenn E., additional, Ivnik, Robert J., additional, Boeve, Bradley F., additional, Edland, Steven D., additional, Kokmen, Emre, additional, Tangalos, Eric G., additional, Petersen, Ronald C., additional, and Jack Jr., Clifford R., additional

Published
2002
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183. Proof of concept demonstration of optimal composite MRI endpoints for clinical trials

Author

Edland, Steven D., Ard, M. Colin, Sridhar, Jaiashre, Cobia, Derin, Martersteck, Adam, Mesulam, M.-Marsel, and Rogalski, Emily J.

Abstract

Atrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with traditional cognitive and functional outcome measures.

Published
2016
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188. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis

Author

Castro, Elena, primary, Edland, Steven D., additional, Lee, Lin, additional, Ogburn, Charles E., additional, Deeb, Samir S., additional, Brown, Greg, additional, Panduro, Arturo, additional, Riestra, Roberto, additional, Tilvis, Reijo, additional, Louhija, Jukka, additional, Penttinen, Risto, additional, Erkkola, Risto, additional, Wang, Lan, additional, Martin, George M., additional, and Oshima, Junko, additional

Published
2000
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189. Clinical outcomes of diabetic patients at a student-run free clinic project.

Author

Smith, Sunny D, Marrone, Laura, Gomez, Alex, Johnson, Michelle L, Edland, Steven D, and Beck, Ellen

Abstract

Objectives: Our objective was to determine if the quality of care of diabetic patients at a Student-Run Free Clinic Project (SRFCP) meets the standard of care, is comparable with other published outcomes, and whether pertinent diabetic clinical indicators improve over time.Methods: The authors conducted a retrospective chart review of diabetic patients at three University of California-San Diego (UCSD) SRFCP sites from December 1, 2008 to December 1, 2009 (n=182), calculated the percentage who received recommended screening tests, percent at goal, and compared these to published outcomes using Fisher's exact tests. Baseline measures were compared to most recent values using paired t tests.Results: The percentage of patients who received recommended screening tests (process measures) was blood pressure (BP) 100%, HbA1c 99.5%, creatinine 99.5%, LDL 93%, HDL and triglycerides 88%, microalbumin/creatinine ratio 80%, and ophthalmology exam 32%. Intermediate outcomes included: 70% of patients were at LDL goal <100, 70% had microalbumin/creatinine ratio <30, 61% of males were at HDL goal %gt;40, 47% of females at HDL goal>50, 52% with triglycerides <150, 45% had BP <130/80, and 30% of patients had HbA1c <7. Mean HbA1c, LDL, HDL, triglycerides and blood pressure improved significantly over time.Conclusions: Diabetic patients at UCSD SRFCP reached goals for both process measures and intermediate outcomes at rates that meet or exceed published outcomes of insured and uninsured diabetics on nearly all measures, with the exception of ophthalmology screening. Glycemic control, cholesterol levels, and blood pressure improved significantly during care at the UCSD SRFCP. [ABSTRACT FROM AUTHOR]

Published
2014

191. Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cy/Arg, and its stability in a population of Finnish centenarians

Author

Castro, Elena, primary, Ogburn, Charles E., additional, Hunt, Kristin E., additional, Tilvis, Reijo, additional, Louhija, Jukka, additional, Penttinen, Risto, additional, Erkkola, Risto, additional, Panduro, Arturo, additional, Riestra, Roberto, additional, Piussan, Charles, additional, Deeb, Samir S., additional, Wang, Lan, additional, Edland, Steven D., additional, Martin, George M., additional, and Oshima, Junko, additional

Published
1999
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200. Behavior Rating Scale for Dementia

Author

Tariot, Pierre N., primary, Mack, James L., additional, Patterson, Marian B., additional, Edland, Steven D., additional, Weiner, Myron F., additional, Fillenbaum, Gerda, additional, Blazina, Linda, additional, Teri, Linda, additional, Rubin, Eugene, additional, Mortimer, James A., additional, and Stern, Yaakov, additional

Published
1995
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