Proof of concept demonstration of optimal composite MRI endpoints for clinical trials

Authors :: Edland, Steven D.
Ard, M. Colin
Sridhar, Jaiashre
Cobia, Derin
Martersteck, Adam
Mesulam, M.-Marsel
Rogalski, Emily J.
Source :: Alzheimer's & Dementia: Translational Research & Clinical Interventions; September 2016, Vol. 2 Issue: 3 p177-181, 5p
Publication Year :: 2016
Abstract: Atrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with traditional cognitive and functional outcome measures.

Language :: English
ISSN :: 23528737
Volume :: 2
Issue :: 3
Database :: Supplemental Index
Journal :: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publication Type :: Periodical
Accession number :: ejs39443810
Full Text :: https://doi.org/10.1016/j.trci.2016.05.002

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