1,015 results on '"Dorronsoro, Miren"'
Search Results
152. A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Murphy, Neil, Cross, Amanda J., Abubakar, Mustapha, Jenab, Mazda, Aleksandrova, Krasimira, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kühn, Tilman, Katzke, Verena A., Tjønneland, Anne, Petersen, Kristina E. N., Overvad, Kim, Quirós, J. Ramón, Jakszyn, Paula, Molina-Montes, Esther, Dorronsoro, Miren, Huerta, José-María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Peeters, Petra H., Ohlsson, Bodil, Ericson, Ulrika, Palmqvist, Richard, Nyström, Hanna, Weiderpass, Elisabete, Skeie, Guri, Freisling, Heinz, Kong, So Yeon, Tsilidis, Kostas, Muller, David C., Riboli, Elio, and Gunter, Marc J
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Phenotypes -- Research ,Obesity -- Complications and side effects -- Research ,Colorectal cancer -- Genetic aspects -- Risk factors -- Investigations -- Research ,Biological sciences - Abstract
Background Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. Methods and Findings The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m.sup.2 ), (2) metabolically healthy/overweight (BMI [greater than or equal to] 25 kg/m.sup.2 ), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m.sup.2 ), and (4) metabolically unhealthy/overweight (BMI [greater than or equal to] 25 kg/m.sup.2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [[greater than or equal to]80 cm for women and [greater than or equal to]94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p-value of Conclusions These results support the idea that individuals with the metabolically healthy/overweight phenotype (with normal insulin levels) are at lower colorectal cancer risk than those with hyperinsulinaemia. The combination of anthropometric measures with metabolic parameters, such as C-peptide, may be useful for defining strata of the population at greater risk of colorectal cancer., Author(s): Neil Murphy 1,*, Amanda J. Cross 1, Mustapha Abubakar 2, Mazda Jenab 3, Krasimira Aleksandrova 4, Marie-Christine Boutron-Ruault 5,6,7, Laure Dossus 5,6,7, Antoine Racine 5,6,7, Tilman Kühn 8, Verena [...]
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- 2016
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153. Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
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Jenab, Mazda, Riboli, Elio, Cleveland, Rebecca J., Norat, Teresa, Rinaldi, Sabina, Nieters, Alexandra, Biessy, Carine, Tjnneland, Ann, Olsen, Anja, Overvad, Kim, Grnbæk, Henning, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Linseisen, Jakob, Boeing, Heiner, Pischon, Tobias, Trichopoulos, Dimitrios, Oikonomou, Eleni, Trichopoulou, Antonia, Panico, Salvatore, Vineis, Paolo, Berrino, Franco, Tumino, Rosario, Masala, Giovanna, Peters, Petra H., van Gils, Carla H., Bueno-de-Mesquita, Bas H., Ocké, Marga C., Lund, Eiliv, Mendez, Michelle A., Tormo, María José, Barricarte, Aurelio, Martínez-García, Carmen, Dorronsoro, Miren, Quirós, José Ramón, Hallmans, Göran, Palmqvist, Richard, Berglund, Göran, Manjer, Jonas, Key, Timothy, Allen, Naomi E., Bingham, Sheila, Khaw, Kay-Tee, Cust, Anne, and Kaaks, Rudolf
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- 2007
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154. Dietary patterns and survival of older Europeans: The EPIC-Elderly Study (European Prospective Investigation into Cancer and Nutrition)
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Bamia, Christina, Trichopoulos, Dimitrios, Ferrari, Pietro, Overvad, Kim, Bjerregaard, Lone, Tjønneland, Anne, Halkjær, Jytte, Clavel-Chapelon, Francoise, Kesse, Emmanuelle, Boutron-Ruault, Marie-Christine, Boffetta, Paolo, Nagel, Gabriele, Linseisen, Jacob, Boeing, Heiner, Hoffmann, Kurt, Kasapa, Christina, Orfanou, Anastasia, Travezea, Chrysoula, Slimani, Nadia, Norat, Teresa, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H Bas, Waijers, Patricia MCM, Peeters, Petra HM, van der Schouw, Yvonne T, Berenguer, Antonio, Martinez-Garcia, Carmen, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Berglund, Goran, Wirfalf, Elisabet, Johansson, Ingegerd, Johansson, Gerd, Bingham, Sheila, Khaw, Kay-Tee, Spencer, Elizabeth A, Key, Tim, Riboli, Elio, and Trichopoulou, Antonia
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- 2007
155. Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)1–3
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Agudo, Antonio, Cabrera, Laia, Amiano, Pilar, Ardanaz, Eva, Barricarte, Aurelio, Berenguer, Toni, Chirlaque, María D, Dorronsoro, Miren, Jakszyn, Paula, Larrañaga, Nerea, Martínez, Carmen, Navarro, Carmen, Quirós, Jose R, Sánchez, María J, Tormo, María J, and González, Carlos A
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- 2007
156. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Rohrmann, Sabine, Linseisen, Jakob, Boshuizen, Hendriek C., Whittaker, John, Agudo, Antonio, Vineis, Paolo, Boffetta, Paolo, Jensen, Majken K., Olsen, Anja, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Bergmann, Manuela M., Boeing, Heiner, Allen, Naomi, Key, Tim, Bingham, Sheila, Khaw, Kay-Tee, Kyriazi, Georgia, Soukara, Stavroula, Trichopoulou, Antonia, Panico, Salvatore, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Büchner, Frederike L., Gram, Inger Torhild, Lund, Eiliv, Ardanaz, Eva, Chirlaque, María-Dolores, Dorronsoro, Miren, Pérez, Maria-José Sánchez, Quirós, Jose R., Berglund, Göran, Janzon, Lars, Rasmuson, Torgny, Weinehall, Lars, Ferrari, Pietro, Jenab, Mazda, Norat, Teresa, and Riboli, Elio
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- 2006
157. Intake and food sources of nitrites and N-nitrosodimethylamine in Spain
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Jakszyn, Paula, Agudo, Antonio, Berenguer, Antonio, Ibáñez, Raquel, Amiano, Pilar, Pera, Guillem, Ardanaz, Eva, Barricarte, Aurelio, Chirlaque, María Dolores, Dorronsoro, Miren, Larrañaga, Nerea, Martinez, Carmen, Navarro, Carmen, Quirós, José R, Sanchéz, María José, Tormo, María José, and González, Carlos A
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- 2006
158. Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
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Pischon, Tobias, Lahmann, Petra H., Boeing, Heiner, Friedenreich, Christine, Norat, Teresa, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Guernec, Gregory, Bergmann, Manuela M., Linseisen, Jakob, Becker, Nikolaus, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Boshuizen, Hendriek C., Van Guelpen, Bethany, Palmqvist, Richard, Berglund, Göran, Gonzalez, Carlos Alberto, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Martinez, Carmen, Quirós, J. Ramón, Roddam, Andrew, Allen, Naomi, Bingham, Sheila, Khaw, Kay-Tee, Ferrari, Pietro, Kaaks, Rudolf, Slimani, Nadia, and Riboli, Elio
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- 2006
159. Air pollution and risk of lung cancer in a prospective study in Europe
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Vineis, Paolo, Hoek, Gerard, Krzyzanowski, Michal, Vigna-Taglianti, Federica, Veglia, Fabrizio, Airoldi, Luisa, Autrup, Herman, Dunning, Alison, Garte, Seymour, Hainaut, Pierre, Malaveille, Christian, Matullo, Giuseppe, Overvad, Kim, Raaschou-Nielsen, Ole, Clavel-Chapelon, Francoise, Linseisen, Jacob, Boeing, Heiner, Trichopoulou, Antonia, Palli, Domenico, Peluso, Marco, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-De-Mesquita, Bas H., Peeters, Petra H., Lund, Eylin E., Gonzalez, Carlos A., Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Cirera, Lluis, Quiros, Ramon J., Berglund, Goran, Forsberg, Bertil, Day, Nicholas E., Key, Tim J., Saracci, Rodolfo, Kaaks, Rudolf, and Riboli, Elio
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- 2006
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160. Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC)
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Engeset, Dagrun, Alsaker, Elin, Lund, Eiliv, Welch, Ailsa, Khaw, Kay-Tee, Clavel-Chapelon, Françoise, Thiébaut, Anne, Chajès, Véronique, Key, Timothy J, Allen, Naomi E, Amiano, Pilar, Dorronsoro, Miren, Tjnneland, Anne, Stripp, Connie, Peeters, Petra HM, van Gils, Carla H, Chirlaque, Maria-Dolores, Nagel, Gabriele, Linseisen, Jakob, Ocké, Marga C, Bueno-de-Mesquita, Bas H, Sacerdote, Carlotta, Tumino, Rosario, Ardanaz, Eva, Sánchez, Maria-Jose, Panico, Salvatore, Palli, Domenico, Trichopoulou, Antonia, Kalapothaki, Victoria, Benetou, Vicky, Quirós, Ramón J, Agudo, Antonio, Overvad, Kim, Bjerregaard, Lone, Wirfält, Elisabet, Schulz, Mandy, Boeing, Heiner, Slimani, Nadia, and Riboli, Elio
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- 2006
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161. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)
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González, Carlos A., Pera, Guillem, Agudo, Antonio, Bueno-de-Mesquita, Bas H., Ceroti, Marco, Boeing, Heiner, Schulz, Mandy, Del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Hallmans, Göran, Stenling, Roger, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quiros, José R., Allen, Naomi, Key, Timothy J., Bingham, Sheila, Day, Nicholas E., Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Jensen, Majken K., Olsen, Anja, Tjnneland, Anne, Büchner, Frederike L., Peeters, Petra HM., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Roukos, Dimitrios, Trichopoulou, Antonia, Psaltopoulou, Theodora, Lund, Eiliv, Casagrande, Corinne, Slimani, Nadia, Jenab, Mazda, and Riboli, Elio
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- 2006
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162. Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)
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González, Carlos A., Jakszyn, Paula, Pera, Guillem, Agudo, Antonio, Bingham, Sheila, Palli, Domenico, Ferrari, Pietro, Boeing, Heiner, del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Nesi, Gabriella, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Nyrén, Olof, Hallmans, Göran, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R., Allen, Naomi, Key, Timothy J., Day, Nicholas E., Linseisen, Jakob, Nagel, Gabriele, Bergmann, Manuela M., Overvad, Kim, Jensen, Majken K., Tjonneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H. Bas, Ocke, Marga, Peeters, Petra H. M., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Psaltopoulou, Theodora, Roukos, Dimitrios, Lund, Eiliv, Hemon, Bertrand, Kaaks, Rudolf, Norat, Teresa, and Riboli, Elio
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- 2006
163. Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Pischon, Tobias, Lahmann, Petra H., Boeing, Heiner, Tjnneland, Anne, Halkjær, Jytte, Overvad, Kim, Klipstein-Grobusch, Kerstin, Linseisen, Jakob, Becker, Nikolaus, Trichopoulou, Antonia, Benetou, Vassiliki, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Monninkhof, Evelyn, Peeters, Petra H.M., Bueno-de-Mesquita, Bas H., Büchner, Frederike L., Ljungberg, Börje, Hallmans, Göran, Berglund, Göran, Gonzalez, Carlos Alberto, Dorronsoro, Miren, Gurrea, Aurelio Barricarte, Navarro, Carmen, Martinez, Carmen, Quirós, Ramón J., Roddam, Andrew, Allen, Naomi, Bingham, Sheila, Khaw, Kay-Tee, Kaaks, Rudolf, Norat, Teresa, Slimani, Nadia, and Riboli, Elio
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- 2006
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164. Dietary patterns among older Europeans: the EPIC-Elderly study
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Bamia, Christina, Orfanos, Philippos, Ferrari, Pietro, Overvad, Kim, Hundborg, Heidi H., Tjønneland, Anne, Olsen, Anja, Kesse, Emmanuelle, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Nagel, Gabriele, Boffetta, Paolo, Boeing, Heiner, Hoffmann, Kurt, Trichopoulos, Dimitrios, Baibas, Nikos, Psaltopoulou, Theodora, Norat, Teresa, Slimani, Nadia, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H. B., Ocké, Marga C., Peeters, Petra H., van Rossum, Caroline T., Quirós, José-Ramón, Sánchez, Maria-José, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Berglund, Göran, Wirfält, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Bingham, Sheila, Khaw, Kay-Tee, Spencer, Elizabeth A., Roddam, Andrew W., Riboli, Elio, and Trichopoulou, Antonia
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- 2005
165. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study
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Trichopoulou, Antonia, Orfanos, Philippos, Norat, Teresa, Bueno-de-Mesquita, Bas, Ocké, Marga C, Peeters, Petra HM, van der Schouw, Yvonne T, Boeing, Heiner, Hoffmann, Kurt, Boffetta, Paolo, Nagel, Gabriele, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bamia, Christina, Naska, Androniki, Benetou, Vassiliki, Ferrari, Pietro, Slimani, Nadia, Pera, Guillem, Martinez-Garcia, Carmen, Navarro, Carmen, Rodriguez-Barranco, Miguel, Dorronsoro, Miren, Spencer, Elizabeth A, Key, Timothy J, Bingham, Sheila, Khaw, Kay-Tee, Kesse, Emmanuelle, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Berglund, Goran, Wirfalt, Elisabet, Hallmans, Goran, Johansson, Ingegerd, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Hundborg, Heidi H, Riboli, Elio, and Trichopoulos, Dimitrios
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- 2005
166. Changes in smoking habits in adults: results from a prospective study in Spain
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Agudo, Antonio, Pera, Guillem, Rodriguez, Mauricio, Quiros, J.Ramon, Navarro, Carmen, Martinez, Carmen, Larrañaga, Nerea, Fernandez, Ana, Dorronsoro, Miren, Chirlaque, M.Dolores, Berenguer, Antonio, Barricarte, Aurelio, Ardanaz, Eva, Amiano, Pilar, Tormo, M.Jose, and Gonzalez, Carlos A
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- 2004
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167. Dietary sources of vitamin C, vitamin E and specific carotenoids in Spain
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García-Closas, Reina, Berenguer, Antonio, Tormo, María José, Sánchez, María José, Quirós, José R., Navarro, Carmen, Arnaud, Rosario, Dorronsoro, Miren, Chirlaque, María Dolores, Barricarte, Aurelio, Ardanaz, Eva, Amiano, Pilar, Martinez, Carmen, Agudo, Antonio, and González, Carlos A.
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- 2004
168. Risk of type 2 diabetes according to traditional and emerging anthropometric indices in Spain, a Mediterranean country with high prevalence of obesity: results from a large-scale prospective cohort study
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Huerta José María, Tormo María-José, Chirlaque María-Dolores, Gavrila Diana, Amiano Pilar, Arriola Larraitz, Ardanaz Eva, Rodríguez Laudina, Sánchez María-José, Mendez Michelle, Salmerón Diego, Barricarte Aurelio, Burgui Rosana, Dorronsoro Miren, Larrañaga Nerea, Molina-Montes Esther, Moreno-Iribas Conchi, Quirós José Ramón, Toledo Estefanía, Travier Noémie, González Carlos A, and Navarro Carmen
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Diabetes ,Anthropometry ,Obesity ,Abdominal obesity ,Body mass index ,EPIC ,Spain ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Obesity is a major risk factor for type 2 diabetes mellitus (T2DM). A proper anthropometric characterisation of T2DM risk is essential for disease prevention and clinical risk assessement. Methods Longitudinal study in 37 733 participants (63% women) of the Spanish EPIC (European Prospective Investigation into Cancer and Nutrition) cohort without prevalent diabetes. Detailed questionnaire information was collected at baseline and anthropometric data gathered following standard procedures. A total of 2513 verified incident T2DM cases occurred after 12.1 years of mean follow-up. Multivariable Cox regression was used to calculate hazard ratios of T2DM by levels of anthropometric variables. Results Overall and central obesity were independently associated with T2DM risk. BMI showed the strongest association with T2DM in men whereas waist-related indices were stronger independent predictors in women. Waist-to-height ratio revealed the largest area under the ROC curve in men and women, with optimal cut-offs at 0.60 and 0.58, respectively. The most discriminative waist circumference (WC) cut-off values were 99.4 cm in men and 90.4 cm in women. Absolute risk of T2DM was higher in men than women for any combination of age, BMI and WC categories, and remained low in normal-waist women. The population risk of T2DM attributable to obesity was 17% in men and 31% in women. Conclusions Diabetes risk was associated with higher overall and central obesity indices even at normal BMI and WC values. The measurement of waist circumference in the clinical setting is strongly recommended for the evaluation of future T2DM risk in women.
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- 2013
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169. Anthropometry and the Risk of Lung Cancer in EPIC
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Dewi, Nikmah Utami, Boshuizen, Hendriek C, Johansson, Mattias, Vineis, Paolo, Kampman, Ellen, Steffen, Annika, Tjønneland, Anne, Halkjær, Jytte, Overvad, Kim, Severi, Gianluca, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Li, Kuanrong, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Klinaki, Eleni, Tumino, Rosario, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, Peeters, Petra H, Vermeulen, Roel, Weiderpass, Elisabete, Torhild Gram, Inger, Huerta, José María, Agudo, Antonio, Sánchez, María-José, Ardanaz, Eva, Dorronsoro, Miren, Quirós, José Ramón, Sonestedt, Emily, Johansson, Mikael, Grankvist, Kjell, Key, Tim, Khaw, Kay-Tee, Wareham, Nick, Cross, Amanda J, Norat, Teresa, Riboli, Elio, Fanidi, Anouar, Muller, David, Bueno-de-Mesquita, H Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, and Imperial College Trust
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Male ,obesity ,Lung Neoplasms ,Nutrition and Disease ,Epidemiology ,Comorbidity ,waist to hip ratio ,ORIGINAL CONTRIBUTIONS ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Waist–hip ratio ,Voeding en Ziekte ,Multicenter Studies as Topic ,Medicine ,Prospective Studies ,030212 general & internal medicine ,POPULATION ,Public, Environmental & Occupational Health ,Human Nutrition & Health ,Waist-to-height ratio ,Anthropometry ,Hazard ratio ,Humane Voeding & Gezondheid ,Confounding Factors, Epidemiologic ,11 Medical And Health Sciences ,Middle Aged ,waist circumference ,Europe ,LEANNESS ,030220 oncology & carcinogenesis ,Female ,Life Sciences & Biomedicine ,Adult ,medicine.medical_specialty ,Waist ,body mass index ,waist-to-height ratio ,Risk Assessment ,smoking ,03 medical and health sciences ,Journal Article ,Humans ,COHORT ,Lung cancer ,waist-to-heigh ratio ,METAANALYSIS ,01 Mathematical Sciences ,Aged ,Proportional Hazards Models ,VLAG ,MODEL ANALYSIS ,Science & Technology ,Waist-Hip Ratio ,business.industry ,Proportional hazards model ,CURRENT SMOKERS ,Cancer ,FAT DISTRIBUTION ,medicine.disease ,Diet ,Surgery ,BODY-MASS INDEX ,lung cancer ,business ,Body mass index ,Demography - Abstract
The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)(2)) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.
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- 2016
170. Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study
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May Anne M, Adema Lotte E, Romaguera Dora, Vergnaud Anne-Claire, Agudo Antonio, Ekelund Ulf, Steffen Annika, Orfanos Philippos, Slimani Nadia, Rinaldi Sabina, Mouw Traci, Rohrmann Sabine, Hermann Silke, Boeing Heiner, Bergmann Manuela M, Jakobsen Marianne, Overvad Kim, Wareham Nicholas J, Gonzalez Carlos, Tjonneland Anne, Halkjaer Jytte, Key Timothy J, Spencer Elizabeth A, Hellstrom Veronica, Manjer Jonas, Hedblad Bo, Lund Eiliv, Braaten Tonje, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Rodríguez Laudina, Sánchez Maria J, Dorronsoro Miren, Barricarte Aurelio, Huerta Jose, Naska Androniki, Trichopoulou Antonia, Palli Domenico, Pala Valeria, Norat Teresa, Mattiello Amalia, Tumino Rosario, van der A Daphne, Bueno-de-Mesquita H, Riboli Elio, and Peeters Petra HM
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Non-response ,Non-participation ,Lost-to-follow-up ,Medicine (General) ,R5-920 - Abstract
Abstract Background This paper discusses whether baseline demographic, socio-economic, health variables, length of follow-up and method of contacting the participants predict non-response to the invitation for a second assessment of lifestyle factors and body weight in the European multi-center EPIC-PANACEA study. Methods Over 500.000 participants from several centers in ten European countries recruited between 1992 and 2000 were contacted 2–11 years later to update data on lifestyle and body weight. Length of follow-up as well as the method of approaching differed between the collaborating study centers. Non-responders were compared with responders using multivariate logistic regression analyses. Results Overall response for the second assessment was high (81.6%). Compared to postal surveys, centers where the participants completed the questionnaire by phone attained a higher response. Response was also high in centers with a short follow-up period. Non-response was higher in participants who were male (odds ratio 1.09 (confidence interval 1.07; 1.11), aged under 40 years (1.96 (1.90; 2.02), living alone (1.40 (1.37; 1.43), less educated (1.35 (1.12; 1.19), of poorer health (1.33 (1.27; 1.39), reporting an unhealthy lifestyle and who had either a low (25, 1.08 (1.06; 1.10); especially ≥30 kg/m2, 1.26 (1.23; 1.29)). Conclusions Cohort studies may enhance cohort maintenance by paying particular attention to the subgroups that are most unlikely to respond and by an active recruitment strategy using telephone interviews.
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- 2012
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171. Circulating Fetuin-A and Risk of Type 2 Diabetes
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Kroeger, Janine, Meidtner, Karina, Stefan, Norbert, Guevara, Marcela, Kerrison, Nicola D., Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner (apl. Prof. Dr.), Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Maria Huerta, Jose, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kuehn, Tilman, Mancini, Francesca Romana, Mattiello, Amalia, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Ramon Quiros, J., Rolandsson, Olov, Sacerdote, Carlotta, Sala, Nuria, Salamanca-Fernandez, Elena, Sluijs, Ivonne, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tsilidis, Konstantinos K., Tumino, Rosario, van der Schouw, Yvonne T., Forouhi, Nita G., Sharp, Stephen J., Langenberg, Claudia, Riboli, Elio, Schulze, Matthias B. (Prof. Dr.), and Wareham, Nicholas J.
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ddc:570 ,Institut für Biochemie und Biologie - Abstract
Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. Weaimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 mu g/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population.
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- 2018
172. Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)
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Nagel, Gabriele, Stafoggia, Massimo, Pedersen, Marie, Andersen, Zorana J, Galassi, Claudia, Munkenast, Jule, Jaensch, Andrea, Sommar, Johan, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Pedersen, Nancy L, Östenson, Claes-Göran, Fratiglioni, Laura, Sørensen, Mette, Tjønneland, Anne, Peeters, Petra H, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J, Concin, Hans, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo-Uria, Ibon, Amiano, Pilar, Dorronsoro, Miren, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Weinmayr, Gudrun, One Health Chemisch, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI ME (Milieu epidemiologie), One Health Chemisch, dIRAS RA-2, dIRAS RA-I&I RA, and LS IRAS EEPI ME (Milieu epidemiologie)
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,air pollution ,010501 environmental sciences ,ESCAPE ,01 natural sciences ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,upper aerodigestive tract cancer ,Epidemiology ,Humans ,Medicine ,Prospective Studies ,0105 earth and related environmental sciences ,business.industry ,Proportional hazards model ,Incidence ,Stomach ,Incidence (epidemiology) ,gastric cancer ,Hazard ratio ,Confounding ,epidemiology ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Europe ,medicine.anatomical_structure ,Oncology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM10), below 2.5 µm (PM2.5), between 2.5 and 10 µm (PMcoarse), PM2.5 absorbance and nitrogen oxides (NO2 and NOX) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m3 of PM2.5 was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.
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- 2018
173. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
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van Duijnhoven, Fraenzel J. B. Jenab, Mazda Hveem, Kristian and Siersema, Peter D. Fedirko, Veronika Duell, Eric J. Kampman, Ellen Halfweeg, Anouk van Kranen, Henk J. van den Ouweland, Jody M. W. Weiderpass, Elisabete Murphy, Neil Langhammer, Arnulf Ness-Jensen, Eivind Olsen, Anja Tjonneland, Anne and Overvad, Kim Cadeau, Claire Kvaskoff, Marina Boutron-Ruault, Marie-Christine Katzke, Verena A. Kuehn, Tilman Boeing, Heiner Trichopoulou, Antonia Kotanidou, Anastasia Kritikou, Maria Palli, Domenico Agnoli, Claudia Tumino, Rosario and Panico, Salvatore Matullo, Giuseppe Peeters, Petra Brustad, Magritt Olsen, Karina Standahl Lasheras, Cristina and Obon-Santacana, Mireia Sanchez, Maria-Jose Dorronsoro, Miren and Chirlaque, Maria-Dolores Barricarte, Aurelio Manjer, Jonas and Almquist, Martin Renstrom, Frida Ye, Weimin Wareham, Nick and Khaw, Kay-Tee Bradbury, Kathryn E. Freisling, Heinz and Aune, Dagfinn Norat, Teresa Riboli, Elio Bueno-de-Mesquita, H. B(as)
- Abstract
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-TrOndelag Health Study’s second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D-2 and 25(OH)D-3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of 25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
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- 2018
174. Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer
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Butt, Julia, primary, Jenab, Mazda, additional, Pawlita, Michael, additional, Overvad, Kim, additional, Tjonneland, Anne, additional, Olsen, Anja, additional, Boutron-Ruault, Marie-Christine, additional, Carbonnel, Franck, additional, Mancini, Francesca Romana, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Palli, Domenico, additional, Pala, Valeria Maria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, van Gils, Carla H., additional, Vermeulen, Roel C.H., additional, Weiderpass, Elisabete, additional, Quirós, José Ramón, additional, Duell, Eric Jeffrey, additional, Sánchez, Maria-Jose, additional, Dorronsoro, Miren, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Van Guelpen, Bethany, additional, Harlid, Sophia, additional, Perez-Cornago, Aurora, additional, Gunter, Marc J., additional, Murphy, Neil, additional, Freisling, Heinz, additional, Aune, Dagfinn, additional, Waterboer, Tim, additional, and Hughes, David J., additional
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- 2019
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175. Predicting Circulating CA125 Levels among Healthy Premenopausal Women
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Sasamoto, Naoko, primary, Babic, Ana, additional, Rosner, Bernard A., additional, Fortner, Renée T., additional, Vitonis, Allison F., additional, Yamamoto, Hidemi, additional, Fichorova, Raina N., additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Kvaskoff, Marina, additional, Fournier, Agnès, additional, Romana Mancini, Francesca, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Peppa, Eleni, additional, Karakatsani, Anna, additional, Palli, Domenico, additional, Pala, Valeria, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Grasso, Chiara C., additional, Onland-Moret, N. Charlotte, additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Lujan-Barroso, Leila, additional, Rodríguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra, additional, Barricarte, Aurelio, additional, Dorronsoro, Miren, additional, Idahl, Annika, additional, Lundin, Eva, additional, Sartor, Hanna, additional, Khaw, Kay-Tee, additional, Key, Timothy J., additional, Muller, David, additional, Riboli, Elio, additional, Gunter, Marc J., additional, Dossus, Laure, additional, Kaaks, Rudolf, additional, Cramer, Daniel W., additional, Tworoger, Shelley S., additional, and Terry, Kathryn L., additional
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- 2019
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176. Gallstones and incident colorectal cancer in a large pan‐European cohort study
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Ward, Heather A, primary, Murphy, Neil, additional, Weiderpass, Elisabete, additional, Leitzmann, Michael F, additional, Aglago, Elom, additional, Gunter, Marc J, additional, Freisling, Heinz, additional, Jenab, Mazda, additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Carbonnel, Franck, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Merino, Susana, additional, Zamora‐Ros, Raul, additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, Maria‐Dolores, additional, Barricarte, Aurelio, additional, Perez‐Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Bueno‐de‐Mesquita, Bas, additional, Vermeulen, Roel, additional, Van Gils, Carla, additional, Nyström, Hanna, additional, Rutegård, Martin, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, and Cross, Amanda J, additional
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- 2019
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177. The association of education with body mass index and waist circumference in the EPIC-PANACEA study
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Vineis Paolo, Masala Giovanna, Tumino Rosario, Mattiello Amalia, Agnoli Claudia, Halkjær Jytte, Tjønneland Anne, Jakobsen Marianne, Overvad Kim, Bueno-de-Mesquita H Bas, van Boeckel Petra GA, Wareham Nicholas J, Khaw Kay-Tee, Crowe Francesca L, Rodríguez Laudina, Barricarte Aurelio, Dorronsoro Miren, Molina Esther, Tormo Maria-Jose, Travier Noemie, Romaguera Dora, Besson Herve, Kunst Anton, May Anne M, Linseisen Jakob, Rohrmann Sabine, Hermann Silke, Naska Androniki, Orfanos Philippos, Trichopoulou Antonia, Kaaks Rudolf, Bergmann Manuela M, Steffen Annika, Van Guelpen Bethany, Johansson Ingegerd, Borgquist Signe, Manjer Jonas, Braaten Tonje, Fagherazzi Guy, Clavel-Chapelon Françoise, Mouw Traci, Norat Teresa, Riboli Elio, Rinaldi Sabina, Slimani Nadia, and Peeters Petra HM
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socioeconomic status ,education ,BMI ,waist circumference ,cohort study ,EPIC ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC, measured by trained personnel in most participating centers, were modeled as continuous dependent variables. Associations were estimated using multilevel mixed effects linear regression models. Results Compared with the lowest education level, BMI and WC were significantly lower for all three higher education categories, which was consistent for all countries. Women with university degree had a 2.1 kg/m2 lower BMI compared with women with lowest education level. For men, a statistically significant, but less pronounced difference was observed (1.3 kg/m2). The association between WC and education level was also of greater magnitude for women: compared with the lowest education level, average WC of women was lower by 5.2 cm for women in the highest category. For men the difference was 2.9 cm. Conclusion In this European cohort, there is an inverse association between higher BMI as well as higher WC and lower education level. Public Health Programs that aim to reduce overweight and obesity should primarily focus on the lower educated population.
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- 2011
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178. Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
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Park, Jin Young, primary, Bueno‐de‐Mesquita, H. Bas, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Batlle, Jordi, additional, Tjønneland, Anne, additional, Kyro, Cecilie, additional, Rebours, Vinciane, additional, Boutron‐Ruault, Marie‐Christine, additional, Mancini, Francesca Romana, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, La Vecchia, Carlo, additional, Kritikou, Maria, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Peeters, Petra H., additional, Skeie, Guri, additional, Merino, Susana, additional, Duell, Eric J., additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, Maria‐Dolores, additional, Ardanaz, Eva, additional, Gylling, Björn, additional, Schneede, Jörn, additional, Ericson, Ulrika, additional, Sternby, Hanna, additional, Khaw, Kay‐Tee, additional, Bradbury, Kathryn E., additional, Huybrechts, Inge, additional, Aune, Dagfinn, additional, Vineis, Paolo, additional, and Slimani, Nadia, additional
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- 2018
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179. Breast Cancer Risk After Recent Childbirth
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Nichols, Hazel B., primary, Schoemaker, Minouk J., additional, Cai, Jianwen, additional, Xu, Jiawei, additional, Wright, Lauren B., additional, Brook, Mark N., additional, Jones, Michael E., additional, Adami, Hans-Olov, additional, Baglietto, Laura, additional, Bertrand, Kimberly A., additional, Blot, William J., additional, Boutron-Ruault, Marie-Christine, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Giles, Graham G., additional, Gram, Inger T., additional, Hankinson, Susan E., additional, Hoffman-Bolton, Judy, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kitahara, Cari M., additional, Larsson, Susanna C., additional, Linet, Martha, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Pala, Valeria, additional, Palmer, Julie R., additional, Peeters, Petra H., additional, Riboli, Elio, additional, Sund, Malin, additional, Tamimi, Rulla M., additional, Tjønneland, Anne, additional, Trichopoulou, Antonia, additional, Ursin, Giske, additional, Vatten, Lars, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Wolk, Alicja, additional, Zheng, Wei, additional, Weinberg, Clarice R., additional, Swerdlow, Anthony J., additional, and Sandler, Dale P., additional
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- 2018
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180. Greenhouse gases emissions from the diet and risk of death and chronic diseases in the EPIC-Spain cohort.
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González, Carlos A, Bonet, Catalina, Pablo, Miguel de, Sanchez, María José, Salamanca-Fernandez, Elena, Dorronsoro, Miren, Amiano, Pilar, Huerta, Jose María, Chirlaque, María Dolores, Ardanaz, Eva, Barricarte, Aurelio, Quirós, Jose Ramón, Agudo, Antonio, and Ferrer, Marta Guadalupe Rivera
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CHRONIC disease risk factors ,MORTALITY risk factors ,AGE distribution ,CARBON dioxide ,CONFIDENCE intervals ,CORONARY disease ,DIET ,GREENHOUSE gases ,INGESTION ,MEAT ,TYPE 2 diabetes ,EDUCATIONAL attainment ,DESCRIPTIVE statistics - Abstract
Background Evidence from the scientific literature shows a significant variation in greenhouse gas (GHG) emissions from the diet, according to the type of food consumed. We aim to analyze the relationship between the daily dietary GHG emissions according to red meat, fruit and vegetables consumption and their relationship with risk of total mortality, and incident risk of chronic diseases. Methods We examined data on the EPIC-Spain prospective study, with a sample of 40 621 participants. Dietary GHG emission values were calculated for 57 food items of the EPIC study using mean emission data from a systematic review of 369 published studies. Results Dietary GHG emissions (kgCO
2 eq/day), per 2000 kcal, were 4.7 times higher in those with high red-meat consumption (>140 g/day) than those with low consumption (<70 g/day). The average dietary GHG emissions were similar in males and females, but it was significantly higher in youngest people and in those individuals with lower educational level, as well as for northern EPIC centers of Spain. We found a significant association with the risk of mortality comparing the third vs. the first tertile of dietary GHG emissions [hazard ratio (HR) 1.095; 95% confidence interval (CI) 1.007–1.19; trend test 0.037]. Risk of coronary heart disease (HR 1.26; 95% CI 1.08–1.48; trend test 0.003) and risk of type 2 diabetes (HR 1.24; 95% CI 1.11–1.38; trend test 0.002) showed significant association as well. Conclusions Decreasing red-meat consumption would lead to reduce GHG emissions from diet and would reduce risk of mortality, coronary heart disease and type 2 diabetes. [ABSTRACT FROM AUTHOR]- Published
- 2021
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181. Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study
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Martinez Carmen, Agudo Antonio, Lund E Eiliv, Peeters Petra H, Bueno-De-Mesquita H Bas, Panico Salvatore, Tumino Rosario, Krogh Vittorio, Palli Domenico, Trichopoulou Antonia, Boeing Heiner, Linseisen Jacob, Clavel-Chapelon Francoise, Raaschou-Nielsen Ole, Overvad Kim, Airoldi Luisa, Veglia Fabrizio, Vigna-Taglianti Federica, Krzyzanowski Michal, Hoek Gerard, Vineis Paolo, Dorronsoro Miren, Barricarte Aurelio, Cirera Lluis, Quiros J Ramon, Berglund Goran, Manjer Jonas, Forsberg Bertil, Day Nicholas E, Key Tim J, Kaaks Rudolf, Saracci Rodolfo, and Riboli Elio
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Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution. Methods We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air pollution in never smokers and ex-smokers in a large prospective study in 10 European countries (European Prospective Investigation into Cancer and Nutrition)(N = 520,000). We report estimates of the proportion of lung cancers attributable to ETS and air pollution in this population. Results The proportion of lung cancers in never- and ex-smokers attributable to ETS was estimated as between 16 and 24%, mainly due to the contribution of work-related exposure. We have also estimated that 5–7% of lung cancers in European never smokers and ex-smokers are attributable to high levels of air pollution, as expressed by NO2 or proximity to heavy traffic roads. NO2 is the expression of a mixture of combustion (traffic-related) particles and gases, and is also related to power plants and waste incinerator emissions. Discussion We have estimated risks of lung cancer attributable to ETS and traffic-related air pollution in a large prospective study in Europe. Information bias can be ruled out due to the prospective design, and we have thoroughly controlled for potential confounders, including restriction to never smokers and long-term ex-smokers. Concerning traffic-related air pollution, the thresholds for indicators of exposure we have used are rather strict, i.e. they correspond to the high levels of exposure that characterize mainly Southern European countries (levels of NO2 in Denmark and Sweden are closer to 10–20 ug/m3, whereas levels in Italy are around 30 or 40, or higher). Therefore, further reduction in exposure levels below 30 ug/m3 would correspond to additional lung cancer cases prevented, and our estimate of 5–7% is likely to be an underestimate. Overall, our prospective study draws attention to the need for strict legislation concerning the quality of air in Europe.
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- 2007
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182. Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
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Raaschou-Nielsen, Ole, Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H., Aasvang, Gunn Marit, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, Bas, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Föger, Bernhard, Wang, Meng, Tsai, Ming Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Sokhi, Ranjeet, Kooter, Ingeborg, de Hoogh, Kees, Beelen, Rob, Eeftens, Marloes, Vermeulen, Roel, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, Commission of the European Communities, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), and dIRAS RA-I&I RA
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Adult ,Male ,Cancer Research ,Lung Neoplasms ,NO2 ,Cohort Studies ,kidney parenchyma ,Arbetsmedicin och miljömedicin ,LUNG-CANCER ,RENAL-CELL CARCINOMA ,Risk Factors ,USE REGRESSION-MODELS ,PARTICULATE MATTER ,Air Pollution ,Journal Article ,cancer ,Humans ,Oncology & Carcinogenesis ,EXPOSURE ,Particle Size ,Vehicle Emissions ,Medicine(all) ,Air Pollutants ,Cancer och onkologi ,Science & Technology ,MORTALITY ,ESCAPE PROJECT ,cohort ,Environmental Exposure ,Occupational Health and Environmental Health ,Middle Aged ,INHALED ULTRAFINE PARTICLES ,Kidney Neoplasms ,Europe ,Oncology ,PM2.5 ABSORBENCY ,Cancer and Oncology ,Female ,Gasoline ,Particulate Matter ,Life Sciences & Biomedicine ,1112 Oncology And Carcinogenesis ,air pollution, kidney parenchyma, cancer, cohort ,Meta-Analysis - Abstract
Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR=1.57 (95%CI: 0.81-3.01) per 5μg/m(3) PM2.5 and HR=1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. This study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance. This article is protected by copyright. All rights reserved.
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- 2017
183. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
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Fedirko, Veronika Hao Quang Tran Gewirtz, Andrew T. Stepien, Magdalena Trichopoulou, Antonia Aleksandrova, Krasimira and Olsen, Anja Tjonneland, Anne Overvad, Kim Carbonnel, Franck and Boutron-Ruault, Marie-Christine Severi, Gianluca Kuhn, Tilman Kaaks, Rudolf Boeing, Heiner Bamia, Christina and Lagiou, Pagona Grioni, Sara Panico, Salvatore Palli, Domenico Tumino, Rosario Naccarati, Alessio Peeters, Petra H. Bueno-de-Mesquita, H. B. Weiderpass, Elisabete Castano, Jose Maria Huerta Barricarte, Aurelio Sanchez, Maria-Jose and Dorronsoro, Miren Quiros, J. Ramon Agudo, Antonio Sjoberg, Klas Ohlsson, Bodil Hemmingsson, Oskar Werner, Marten and Bradbury, Kathryn E. Khaw, Kay-Tee Wareham, Nick Tsilidis, Konstantinos K. Aune, Dagfinn Scalbert, Augustin Romieu, Isabelle Riboli, Elio Jenab, Mazda
- Abstract
Background: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. Methods: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression. Results: Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70-81.40; P-trend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses. Conclusions: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.
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- 2017
184. Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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Perez-Cornago, Aurora, Appleby, Paul N, Tipper, Sarah, Key, Timothy J., Allen, Naomi E., Nieters, Alexandra, Vermeulen, Roel, Roulland, Sandrine, Casabonne, Delphine, Kaaks, Rudolf, Fortner, Renee T, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Klinaki, Eleni, Hansen, Louise, Tjønneland, Anne, Bonnet, Fabrice, Fagherazzi, Guy, Boutron-Ruault, Marie Christine, Pala, Valeria, Masala, Giovanna, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Dorronsoro, Miren, Quirós, J. Ramón, Barricarte, Aurelio, Gavrila, Diana, Agudo, Antonio, Borgquist, Signe, Rosendahl, Ann H, Melin, Beatrice, Wareham, Nick J, Khaw, Kay-Tee, Gunter, Marc J., Riboli, Elio, Vineis, Paolo, Travis, Ruth C., LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-2
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Adult ,Aged, 80 and over ,Male ,Risk ,Lymphoma ,Middle Aged ,Nutrition Surveys ,Europe ,Multicenter Study ,Socioeconomic Factors ,Risk Factors ,hemic and lymphatic diseases ,Case-Control Studies ,Odds Ratio ,Journal Article ,Humans ,Female ,Insulin-Like Growth Factor I ,Aged ,Follow-Up Studies - Abstract
Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], ptrend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.
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- 2017
185. Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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Perez-Cornago, Aurora Appleby, Paul N. Tipper, Sarah Key, Timothy J. Allen, Naomi E. Nieters, Alexandra Vermeulen, Roel Roulland, Sandrine Casabonne, Delphine Kaaks, Rudolf and Fortner, Renee T. Boeing, Heiner Trichopoulou, Antonia and La Vecchia, Carlo Klinaki, Eleni Hansen, Louise Tjonneland, Anne Bonnet, Fabrice Fagherazzi, Guy Boutron-Ruault, Marie-Christine Pala, Valeria Masala, Giovanna Sacerdote, Carlotta Peeters, Petra H. Bueno-de-Mesquita, H. B(as) and Weiderpass, Elisabete Dorronsoro, Miren Quiros, J. Ramon and Barricarte, Aurelio Gavrila, Diana Agudo, Antonio Borgquist, Signe Rosendahl, Ann H. Melin, Beatrice Wareham, Nick and Khaw, Kay-Tee Gunter, Marc Riboli, Elio Vineis, Paolo and Travis, Ruth C.
- Abstract
Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all >= 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further What’s new? Insulin-like growth factor I does not appear to influence lymphoma risk, according to new results. IGF-I can promote some cancers, but there hasn’t been a prospective epidemiological study examining the link between IGF-I concentration and lymphoma risk. To uncover a link, these authors arranged a NESTED case-control study with participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). They tested for IGF-I in pre-diagnosis samples and found no association between the factor and overall lymphoma risk, nor with any subtype, although the number of cases was small for each subtype, and further studies are necessary.
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- 2017
186. Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
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Fortner, Renee T. Sarink, Danja Schock, Helena Johnson, Theron Tjonneland, Anne Olsen, Anja Overvad, Kim Affret, Aurelie His, Mathilde Boutron-Ruault, Marie-Christine and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Orfanos, Philippos Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Ricceri, Fulvio Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Van Gils, Carla H. Weiderpass, Elisabete Lund, Eiliv Quiros, J. Ramon Agudo, Antonio and Sanchez, Maria-Jose Chirlaque, Maria-Dolores Ardanaz, Eva and Dorronsoro, Miren Key, Tim Khaw, Kay-Tee Rinaldi, Sabina and Dossus, Laure Gunter, Marc Merritt, Melissa A. Riboli, Elio and Kaaks, Rudolf
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musculoskeletal diseases - Abstract
Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer.
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- 2017
187. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Sawada, Norie Wark, Petra A. Merritt, Melissa A. Tsugane, Shoichiro Ward, Heather A. Rinaldi, Sabina Weiderpass, Elisabete Dartois, Laureen His, Mathilde Boutron-Ruault, Marie-Christine Turzanski-Fortner, Renee Kaaks, Rudolf and Overvad, Kim Redondo, Maria-Luisa Travier, Noemie and Molina-Portillo, Elena Dorronsoro, Miren Cirera, Lluis and Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia and Lagiou, Pagona Valanou, Elissavet Masala, Giovanna Pala, Valeria Peeters, Petra H. M. van der Schouw, Yvonne T. and Melander, Olle Manjer, Jonas da Silva, Marisa Skeie, Guri and Tjonneland, Anne Olsen, Anja Gunter, Marc J. Riboli, Elio Cross, Amanda J.
- Abstract
Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in similar to 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95% CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95% CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95% CI = 0.56 - 0.71; women: HRQ5 vs. Q1 = 0.81, 95% CI = 0.70 - 0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95% CI = 0.55 - 0.75; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.49 - 0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95% CI = 0.28 - 0.71; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.40 - 0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.
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- 2017
188. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
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Zamora-Ros, Raul Barupal, Dinesh K. Rothwell, Joseph A. and Jenab, Mazda Fedirko, Veronika Romieu, Isabelle and Aleksandrova, Krasimira Overvad, Kim Kyro, Cecilie and Tjonneland, Anne Affret, Aurelie His, Mathilde and Boutron-Ruault, Marie-Christine Katzke, Verena Kuehn, Tilman and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Kritikou, Maria Saieva, Calogero Agnoli, Claudia de Magistris, Maria Santucci Tumino, Rosario Fasanelli, Francesca and Weiderpass, Elisabete Skeie, Guri Merino, Susana and Jakszyn, Paula Sanchez, Maria-Jose Dorronsoro, Miren and Navarro, Carmen Ardanaz, Eva Sonestedt, Emily Ericson, Ulrika Nilsson, Lena Maria Boden, Stina Bueno-de-Mesquita, H. B. (as) Peeters, Petra H. Perez-Cornago, Aurora Wareham, Nicholas J. Khaw, Kay-Thee Freisling, Heinz Cross, Amanda J. and Riboli, Elio Scalbert, Augustin
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fungi ,food and beverages ,heterocyclic compounds - Abstract
Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
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- 2017
189. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
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Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, Jenab, Mazda, PANICO, SALVATORE, Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. A, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolore, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Kla, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
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Male ,Cancer Research ,European populations ,Risk Factors ,Surveys and Questionnaires ,Surveys and Questionnaire ,Prospective Studies ,INDEX ,Incidence ,Liver Neoplasms ,hepatocellular carcinoma ,Middle Aged ,CANCER ,NUTRITIONAL EPIDEMIOLOGY ,MEDITERRANEAN DIET ,Europe ,Nutritional Statu ,Oncology ,Liver Neoplasm ,dietary fat ,Female ,Case-Control Studie ,Life Sciences & Biomedicine ,Human ,Adult ,Risk ,Carcinoma, Hepatocellular ,cohort study ,dietary fats ,Aged ,Case-Control Studies ,Diet ,Dietary Fats ,Feeding Behavior ,Humans ,Life Style ,Nutritional Status ,Young Adult ,FISH ,INFLAMMATION ,LIVER-DISEASE ,Oncology & Carcinogenesis ,METAANALYSIS ,Science & Technology ,Risk Factor ,Carcinoma ,Hepatocellular ,ACIDS ,digestive system diseases ,Prospective Studie ,Food Habit ,RISK-FACTORS ,European population ,Food Habits ,1112 Oncology And Carcinogenesis - Abstract
The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. What's new? The rise of hepatocellular carcinoma (HCC) incidence in high- and middle-income countries, where relatively high-fat diets are common, suggests a possible etiological role for dietary fat. In the present study, potential associations between HCC and total fat intake, intake of fat subtypes and intake of fat from different sources were explored with data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Total fat intake, where monounsaturated fats predominated, was inversely associated with HCC risk. By contrast, no risk associations were detected for polyunsaturated or saturated fat intake or fat source.
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- 2015
190. Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
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Cheng, Timothy H. T, Gorman, Maggie, Martin, Lynn, Barclay, Ella, Casey, Graham, Newcomb, Polly A., Conti, David V., Schumacher, Fred, Gallinger, Steve, Lindor, Noralane M., Hopper, John, Jenkins, Mark, Hunter, David J., Kraft, Peter, Jacobs, Kevin B., Cox, David G., Yeager, Meredith, Hankinson, Susan E., Wacholder, Sholom, Wang, Zhaoming, Welch, Robert, Hutchinson, Amy, Wang, Junwen, Yu, Kai, Chatterjee, Nilanjan, Orr, Nick, Willett, Walter C., Colditz, Graham A., Ziegler, Regina G., Berg, Christine D., Buys, Saundra S., Mccarty, Catherine A., Feigelson, Heather Spencer, Calle, Eugenia E., Thun, Michael J., Hayes, Richard B., Tucker, Margaret, Gerhard, Daniela S., Fraumeni, Joseph F., Hoover, Robert N., Thomas, Gilles, Chanock, Stephen J., Ciampa, Julia, Gonzalez Bosquet, Jesus, Berndt, Sonja, Amundadottir, Laufey, Diver, W. Ryan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Schumacher, Fredrick R., Cancel Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Andriole, Gerald L., Crawford, E. David, Haiman, Christopher A., Henderson, Brian, Kolonel, Laurence, Marchand, Loic Le, Siddiq, Afshan, Riboli, Elio, Key, Timothy J., Kaaks, Rudolf, Isaacs, William, Isaacs, Sarah, Wiley, Kathleen E., Gronberg, Henrik, Wiklund, Fredrik, Stattin, Pär, Xu, Jianfeng, Zheng, S. Lilly, Sun, Jielin, Vatten, Lars J., Hveem, Kristian, Kumle, Merethe, Purdue, Mark P., Johansson, Mattias, Zelenika, Diana, Toro, Jorge R., Scelo, Ghislaine, Moore, Lee E., Prokhortchouk, Egor, Wu, Xifeng, Kiemeney, Lambertus A., Gaborieau, Valerie, Chow, Wong Ho, Zaridze, David, Matveev, Vsevolod, Lubinski, Jan, Trubicka, Joanna, Szeszenia Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Péter, Fabianova, Eleonora, Bucur, Alexandru, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Colt, Joanne S., Davis, Faith G., Schwartz, Kendra L., Banks, Rosamonde E., Selby, Peter J., Harnden, Patricia, Hsing, Ann W., Grubb, Robert L., Boeing, Heiner, Vineis, Paolo, Clavel Chapelon, Franc¸oise, Palli, Domenico, Tumino, Rosario, Krogh, Vittorio, Duell, Eric J., Quirós, José Ramón, Sanchez, Maria José, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Khaw, Kay Tee, Allen, Naomi E., Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Trichopoulos, Dimitrios, Linseisen, Jakob, Ljungberg, Börje, Overvad, Kim, Tjønneland, Anne, Romieu, Isabelle, Mukeria, Anush, Shangina, Oxana, Stevens, Victoria L., Gapstur, Susan M., Pharoah, Paul D., Easton, Douglas F., Weinstein, Stephanie J., Njølstad, Inger, Tell, Grethe S., Stoltenberg, Camilla, Kumar, Rajiv, Koppova, Kvetoslava, Benhamou, Simone, Oosterwijk, Egbert, Vermeulen, Sita H., Aben, Katja K. H., Van Der Marel, Saskia L., Ye, Yuanqing, Wood, Christopher G., Pu, Xia, Mazur, Alexander M., Boulygina, Eugenia S., Chekanov, Nikolai N., Foglio, Mario, Lechner, Doris, Gut, Ivo, Heath, Simon, Blanche, Hélène, Skryabin, Konstantin G., Mckay, James D., Rothman, Nathaniel, Lathrop, Mark, Brennan, Paul, Saunders, Brian, Thomas, Huw, Clark, Sue, Tomlinson, Ian, PANICO, SALVATORE, Cheng, Timothy H. T, Gorman, Maggie, Martin, Lynn, Barclay, Ella, Casey, Graham, Newcomb, Polly A., Conti, David V., Schumacher, Fred, Gallinger, Steve, Lindor, Noralane M., Hopper, John, Jenkins, Mark, Hunter, David J., Kraft, Peter, Jacobs, Kevin B., Cox, David G., Yeager, Meredith, Hankinson, Susan E., Wacholder, Sholom, Wang, Zhaoming, Welch, Robert, Hutchinson, Amy, Wang, Junwen, Yu, Kai, Chatterjee, Nilanjan, Orr, Nick, Willett, Walter C., Colditz, Graham A., Ziegler, Regina G., Berg, Christine D., Buys, Saundra S., Mccarty, Catherine A., Feigelson, Heather Spencer, Calle, Eugenia E., Thun, Michael J., Hayes, Richard B., Tucker, Margaret, Gerhard, Daniela S., Fraumeni, Joseph F., Hoover, Robert N., Thomas, Gille, Chanock, Stephen J., Ciampa, Julia, Gonzalez Bosquet, Jesu, Berndt, Sonja, Amundadottir, Laufey, Diver, W. Ryan, Albanes, Demetriu, Virtamo, Jarmo, Weinstein, Stephanie, Schumacher, Fredrick R., Cancel Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Andriole, Gerald L., Crawford, E. David, Haiman, Christopher A., Henderson, Brian, Kolonel, Laurence, Marchand, Loic Le, Siddiq, Afshan, Riboli, Elio, Key, Timothy J., Kaaks, Rudolf, Isaacs, William, Isaacs, Sarah, Wiley, Kathleen E., Gronberg, Henrik, Wiklund, Fredrik, Stattin, Pär, Xu, Jianfeng, Zheng, S. Lilly, Sun, Jielin, Vatten, Lars J., Hveem, Kristian, Kumle, Merethe, Purdue, Mark P., Johansson, Mattia, Zelenika, Diana, Toro, Jorge R., Scelo, Ghislaine, Moore, Lee E., Prokhortchouk, Egor, Wu, Xifeng, Kiemeney, Lambertus A., Gaborieau, Valerie, Chow, Wong Ho, Zaridze, David, Matveev, Vsevolod, Lubinski, Jan, Trubicka, Joanna, Szeszenia Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Péter, Fabianova, Eleonora, Bucur, Alexandru, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Colt, Joanne S., Davis, Faith G., Schwartz, Kendra L., Banks, Rosamonde E., Selby, Peter J., Harnden, Patricia, Hsing, Ann W., Grubb, Robert L., Boeing, Heiner, Vineis, Paolo, Clavel Chapelon, Franc¸oise, Palli, Domenico, Tumino, Rosario, Krogh, Vittorio, Panico, Salvatore, Duell, Eric J., Quirós, José Ramón, Sanchez, Maria José, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Khaw, Kay Tee, Allen, Naomi E., Bueno de Mesquita, H. Ba, Peeters, Petra H. M., Trichopoulos, Dimitrio, Linseisen, Jakob, Ljungberg, Börje, Overvad, Kim, Tjønneland, Anne, Romieu, Isabelle, Mukeria, Anush, Shangina, Oxana, Stevens, Victoria L., Gapstur, Susan M., Pharoah, Paul D., Easton, Douglas F., Weinstein, Stephanie J., Njølstad, Inger, Tell, Grethe S., Stoltenberg, Camilla, Kumar, Rajiv, Koppova, Kvetoslava, Benhamou, Simone, Oosterwijk, Egbert, Vermeulen, Sita H., Aben, Katja K. H., Van Der Marel, Saskia L., Ye, Yuanqing, Wood, Christopher G., Pu, Xia, Mazur, Alexander M., Boulygina, Eugenia S., Chekanov, Nikolai N., Foglio, Mario, Lechner, Dori, Gut, Ivo, Heath, Simon, Blanche, Hélène, Skryabin, Konstantin G., Mckay, James D., Rothman, Nathaniel, Lathrop, Mark, Brennan, Paul, Saunders, Brian, Thomas, Huw, Clark, Sue, and Tomlinson, Ian
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Adenoma ,Allele ,Male ,Genes, Modifier ,Adenomatous Polyposis Coli Protein ,Colorectal Neoplasm ,Middle Aged ,Polymorphism, Single Nucleotide ,Phenotype ,Adenomatous Polyposis Coli ,Genetics ,Female ,Genetic Predisposition to Disease ,DNA Glycosylase ,Germ-Line Mutation ,Genetics (clinical) ,Aged ,Human - Abstract
The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). We investigated whether 18 common colorectal cancer (CRC) predisposition single-nucleotide polymorphisms (SNPs) could help to explain some cases with multiple adenomas who phenocopied FAP or MAP, but had no pathogenic APC or MUTYH variant. No multiple adenoma case had an outlying number of CRC SNP risk alleles, but multiple adenoma patients did have a significantly higher number of risk alleles than population controls (P=5.7 × 10(-7)). The association was stronger in those with ≥10 adenomas. The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation. In FAP patients, the CRC risk score did not differ significantly from the controls, as we expected given the overwhelming effect of pathogenic germline APC variants on the phenotype of these cases. More unexpectedly, we found no evidence that the CRC SNPs act as modifier genes for the number of colorectal adenomas in FAP patients. In conclusion, common colorectal tumour risk alleles contribute to the development of multiple adenomas in patients without pathogenic germline APC or MUTYH variants. This phenotype may have 'polygenic' or monogenic origins. The risk of CRC in relatives of multiple adenoma cases is probably much lower for cases with polygenic disease, and this should be taken into account when counselling such patients.
- Published
- 2015
191. Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries.
- Author
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Ju-Sheng Zheng, Sharp, Stephen J., Fumiaki Imamura, Chowdhury, Rajiv, Gundersen, Thomas E., Steur, Marinka, Sluijs, Ivonne, van der Schouw, Yvonne T., Agudo, Antonio, Aune, Dagfinn, Barricarte, Aurelio, Boeing, Heiner, Chirlaque, María-Dolores, Dorronsoro, Miren, Freisling, Heinz, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, and Gunter, Marc J.
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BIOMARKERS ,CAROTENOIDS ,CONFIDENCE intervals ,FRUIT ,INGESTION ,LONGITUDINAL method ,TYPE 2 diabetes ,VEGETABLES ,VITAMIN C ,DATA analysis software ,DESCRIPTIVE statistics ,DISEASE risk factors - Published
- 2020
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192. Pre‐diagnostic circulating insulin‐like growth factor‐I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition
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Lin, Crystal, primary, Travis, Ruth C., additional, Appleby, Paul N., additional, Tipper, Sarah, additional, Weiderpass, Elisabete, additional, Chang‐Claude, Jenny, additional, Gram, Inger T., additional, Kaaks, Rudolf, additional, Kiemeney, Lambertus A., additional, Ljungberg, Börje, additional, Tumino, Rosario, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Boutron‐Ruault, Marie‐Christine, additional, Manciniveri, Francesca Romana, additional, Severi, Gianluca, additional, Trichopoulou, Antonia, additional, Masala, Giovanna, additional, Sacerdote, Carlotta, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, Bas, additional, Peeters, Petra H., additional, Salamanca‐Fernández, Elena, additional, Chirlaque, Maria‐Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Menéndez, Virginia, additional, Luján‐Barroso, Leila, additional, Liedberg, Fredrik, additional, Freisling, Heinz, additional, Gunter, Marc, additional, Aune, Dagfinn, additional, Cross, Amanda J., additional, Riboli, Elio, additional, Key, Timothy J., additional, and Perez‐Cornago, Aurora, additional
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- 2018
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193. Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort
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Cramer, Daniel W., primary, Fichorova, Raina N., additional, Terry, Kathryn L., additional, Yamamoto, Hidemi, additional, Vitonis, Allison F., additional, Ardanaz, Eva, additional, Aune, Dagfinn, additional, Boeing, Heiner, additional, Brändstedt, Jenny, additional, Boutron-Ruault, Marie-Christine, additional, Chirlaque, Maria-Dolores, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Duell, Eric J., additional, Gram, Inger T., additional, Gunter, Marc, additional, Hansen, Louise, additional, Idahl, Annika, additional, Johnson, Theron, additional, Khaw, Kay-Tee, additional, Krogh, Vittorio, additional, Kvaskoff, Marina, additional, Mattiello, Amalia, additional, Matullo, Giuseppe, additional, Merritt, Melissa A., additional, Nodin, Björn, additional, Orfanos, Philippos, additional, Onland-Moret, N. Charlotte, additional, Palli, Domenico, additional, Peppa, Eleni, additional, Quirós, J. Ramón, additional, Sánchez-Perez, Maria-Jose, additional, Severi, Gianluca, additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Weiderpass, Elisabete, additional, Fortner, Renée T., additional, and Kaaks, Rudolf, additional
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- 2018
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194. Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort
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van Roekel, Eline, primary, Trijsburg, Laura, additional, Assi, Nada, additional, Carayol, Marion, additional, Achaintre, David, additional, Murphy, Neil, additional, Rinaldi, Sabina, additional, Schmidt, Julie, additional, Stepien, Magdalena, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Iqbal, Khalid, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Panico, Salvatore, additional, Peeters, Petra, additional, Bueno-de-Mesquita, Bas, additional, Ardanaz, Eva, additional, Lujan-Barroso, Leila, additional, Quirós, J., additional, Huerta, José, additional, Molina-Portillo, Elena, additional, Dorronsoro, Miren, additional, Tsilidis, Konstantinos, additional, Riboli, Elio, additional, Rostgaard-Hansen, Agnetha, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Weiderpass, Elisabete, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Kotanidou, Anastasia, additional, Håkansson, Anders, additional, Malm, Johan, additional, Weijenberg, Matty, additional, Gunter, Marc, additional, Jenab, Mazda, additional, Johansson, Mattias, additional, Travis, Ruth, additional, Scalbert, Augustin, additional, and Ferrari, Pietro, additional
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- 2018
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195. Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis
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Kröger, Janine, primary, Meidtner, Karina, additional, Stefan, Norbert, additional, Guevara, Marcela, additional, Kerrison, Nicola D., additional, Ardanaz, Eva, additional, Aune, Dagfinn, additional, Boeing, Heiner, additional, Dorronsoro, Miren, additional, Dow, Courtney, additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Freisling, Heinz, additional, Gunter, Marc J., additional, Huerta, José María, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Khaw, Kay Tee, additional, Krogh, Vittorio, additional, Kühn, Tilman, additional, Mancini, Francesca Romana, additional, Mattiello, Amalia, additional, Nilsson, Peter M., additional, Olsen, Anja, additional, Overvad, Kim, additional, Palli, Domenico, additional, Quirós, J. Ramón, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Sala, Núria, additional, Salamanca-Fernández, Elena, additional, Sluijs, Ivonne, additional, Spijkerman, Annemieke M.W., additional, Tjonneland, Anne, additional, Tsilidis, Konstantinos K., additional, Tumino, Rosario, additional, van der Schouw, Yvonne T., additional, Forouhi, Nita G., additional, Sharp, Stephen J., additional, Langenberg, Claudia, additional, Riboli, Elio, additional, Schulze, Matthias B., additional, and Wareham, Nicholas J., additional
- Published
- 2018
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196. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study
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Zheng, Ju-Sheng, primary, Sharp, Stephen J., additional, Imamura, Fumiaki, additional, Koulman, Albert, additional, Schulze, Matthias B., additional, Ye, Zheng, additional, Griffin, Jules, additional, Guevara, Marcela, additional, Huerta, José María, additional, Kröger, Janine, additional, Sluijs, Ivonne, additional, Agudo, Antonio, additional, Barricarte, Aurelio, additional, Boeing, Heiner, additional, Colorado-Yohar, Sandra, additional, Dow, Courtney, additional, Dorronsoro, Miren, additional, Dinesen, Pia T., additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Feskens, Edith J. M., additional, Kühn, Tilman, additional, Katzke, Verena Andrea, additional, Key, Timothy J., additional, Khaw, Kay-Tee, additional, de Magistris, Maria Santucci, additional, Mancini, Francesca Romana, additional, Molina-Portillo, Elena, additional, Nilsson, Peter M., additional, Olsen, Anja, additional, Overvad, Kim, additional, Palli, Domenico, additional, Quirós, Jose Ramón, additional, Rolandsson, Olov, additional, Ricceri, Fulvio, additional, Spijkerman, Annemieke M. W., additional, Slimani, Nadia, additional, Tagliabue, Giovanna, additional, Tjonneland, Anne, additional, Tumino, Rosario, additional, van der Schouw, Yvonne T., additional, Langenberg, Claudia, additional, Riboli, Elio, additional, Forouhi, Nita G., additional, and Wareham, Nicholas J., additional
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- 2017
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197. Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project
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Andersen, Zorana J., primary, Stafoggia, Massimo, additional, Weinmayr, Gudrun, additional, Pedersen, Marie, additional, Galassi, Claudia, additional, Jørgensen, Jeanette T., additional, Oudin, Anna, additional, Forsberg, Bertil, additional, Olsson, David, additional, Oftedal, Bente, additional, Marit Aasvang, Gunn, additional, Aamodt, Geir, additional, Pyko, Andrei, additional, Pershagen, Göran, additional, Korek, Michal, additional, De Faire, Ulf, additional, Pedersen, Nancy L., additional, Östenson, Claes-Göran, additional, Fratiglioni, Laura, additional, Eriksen, Kirsten T., additional, Tjønneland, Anne, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, Bas, additional, Plusquin, Michelle, additional, Key, Timothy J., additional, Jaensch, Andrea, additional, Nagel, Gabriele, additional, Lang, Alois, additional, Wang, Meng, additional, Tsai, Ming-Yi, additional, Fournier, Agnes, additional, Boutron-Ruault, Marie-Christine, additional, Baglietto, Laura, additional, Grioni, Sara, additional, Marcon, Alessandro, additional, Krogh, Vittorio, additional, Ricceri, Fulvio, additional, Sacerdote, Carlotta, additional, Migliore, Enrica, additional, Tamayo-Uria, Ibon, additional, Amiano, Pilar, additional, Dorronsoro, Miren, additional, Vermeulen, Roel, additional, Sokhi, Ranjeet, additional, Keuken, Menno, additional, de Hoogh, Kees, additional, Beelen, Rob, additional, Vineis, Paolo, additional, Cesaroni, Giulia, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Raaschou-Nielsen, Ole, additional
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- 2017
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198. Physical Sports Activity During Leisure Time and Dietary Intake of Foods and Nutrients in a Large Spanish Cohort.
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Tormo, Maria Jose, Navarro, Carmen, Chirlaque, Maria-Dolores, Barber, Xavier, Argilaga, Silvia, Agudo, Antonio, Amiano, Pilar, Barricarte, Aurelio, Beguiristain, Jose M., Dorronsoro, Miren, Gonzalez, Carlos Alberto, Martinez, Carmen, Quiros, Jose Ramon, and Rodriguez, Mauricio
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INGESTION ,NUTRITION ,VITAMINS ,LEISURE - Abstract
Focuses on the dietary pattern of foods and nutrients according to levels of vigorous leisure time physical activity. Use of a validated diet history questionnaire; Effect of intake of some foods and vitamins on physical activity; Measurement of anthropometric indices.
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- 2003
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199. Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study
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Stepien, Magdalena Duarte-Salles, Talita Fedirko, Veronika and Floegel, Anne Barupal, Dinesh Kumar Rinaldi, Sabina and Achaintre, David Assi, Nada Tjonneland, Anne Overvad, Kim and Bastide, Nadia Boutron-Ruault, Marie-Christine Severi, Gianluca Kuehn, Tilman Kaaks, Rudolf Aleksandrova, Krasimira and Boeing, Heiner Trichopoulou, Antonia Bamia, Christina and Lagiou, Pagona Saieva, Calogero Agnoli, Claudia Panico, Salvatore Tumino, Rosario Naccarati, Alessio and Bueno-de-Mesquita, H. B(as) Peeters, Petra H. Weiderpass, Elisabete Ramon Quiros, J. Agudo, Antonio Sanchez, Maria-Jose Dorronsoro, Miren Gavrila, Diana Barricarte, Aurelio Ohlsson, Bodil Sjoberg, Klas Werner, Marten and Sund, Malin Wareham, Nick Khaw, Kay-Tee Travis, Ruth C. and Schmidt, Julie A. Gunter, Marc Cross, Amanda Vineis, Paolo and Romieu, Isabelle Scalbert, Augustin Jenab, Mazda
- Abstract
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95% CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer’s ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.
- Published
- 2016
200. Prospective association of liver function biomarkers with development of hepatobiliary cancers
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Stepien, Magdalena Fedirko, Veronika Duarte-Salles, Talita and Ferrari, Pietro Freisling, Heinz Trepo, Elisabeth and Trichopoulou, Antonia Bamia, Christina Weiderpass, Elisabete and Olsen, Anja Tjonneland, Anne Overvad, Kim Boutron-Ruault, Marie-Christine Fagherazzi, Guy Racine, Antoine Kuehn, Tilman Kaaks, Rudolf Aleksandrova, Krasimira Boeing, Heiner and Lagiou, Pagona Benetou, Vassiliki Trichopoulos, Dimitrios and Palli, Domenico Grioni, Sara Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, H. Bas Peeters, Petra H. Lund, Eiliv Quiros, J. Ramon Napoles, Osmel Companioni Sanchez, Maria-Jose Dorronsoro, Miren Maria Huerta, Jose Ardanaz, Eva Ohlsson, Bodil Sjoberg, Klas and Werner, Marten Nystrom, Hanna Khaw, Kay-Tee Key, Timothy J. and Gunter, Marc Cross, Amanda Riboli, Elio Romieu, Isabelle and Jenab, Mazda
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digestive system - Abstract
Introduction: Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods: A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95% CI). Results: In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT) = 4.23, 95% CI: 2.72-6.59; OR(ALP) = 3.43, 95% CI: 2.31-5.10; OR(AST) = 3.00, 95% CI: 2.04-4.42; OR(ALT) = 2.69, 95% CI: 1.89-3.84; OR(Bilirubin) = 2.25, 95% CI: 1.58-3.20). Each liver enzyme (OR(GGT) = 4.98; 95% CI: 1.75-14.17; OR(AST) = 3.10, 95% CI: 1.04-9.30; OR(ALT) = 2.86, 95% CI: 1.26-6.48, OR(ALP) = 2.31, 95% CI: 1.10-4.86) but not bilirubin (OR(Bilirubin) = 1.46,95% CI: 0.85-2.51) showed a significant association with IHBC. Only ALP was significantly associated with GBTC risk (OR (ALP) = 1.59, 95% CI: 1.20-2.09). Conclusion: This study shows positive associations between circulating liver biomarkers in sera collected prior to cancer diagnoses and the risks of developing HCC or IHBC, but not GBTC. (C) 2016 Elsevier Ltd. All rights reserved.
- Published
- 2016
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