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151. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil

Author

MOSNIER, Emilie, primary, Dusfour, Isabelle, additional, Lacour, Guillaume, additional, Saldanha, Raphael, additional, Guidez, Amandine, additional, Gomes, Margarete S., additional, Sanna, Alice, additional, Epelboin, Yanouk, additional, Restrepo, Johana, additional, Davy, Damien, additional, Demar, Magalie, additional, Djossou, Félix, additional, Douine, Maylis, additional, Ardillon, Vanessa, additional, Nacher, Mathieu, additional, Musset, Lise, additional, and Roux, Emmanuel, additional

Published
2020
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152. Epidemiologic, Clinical, Ultrasonographic, and Cytological Features of Thyroid Nodules in Predicting Malignancy Risk: A Retrospective Study of 442 French Afro-Caribbean Patients

Author

Joseph-Auguste, Johan, primary, Lin, Lucien, additional, Demar, Magalie, additional, Duffas, Olivier, additional, Molinie, Vincent, additional, Sulpicy, Caroline, additional, Dorival, Marie-Josée, additional, Luxembourger, Olivier, additional, and Sabbah, Nadia, additional

Published
2020
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155. Resurgence risk for malaria, characterization of a recent outbreak in a Amazonian border area -French Guiana/Brazil-

Author

MOSNIER, Emilie, primary, Dusfour, Isabelle, additional, Lacour, Guillaume, additional, Saldanha, Raphael, additional, Guidez, Amandine, additional, Gomes, Margarete S., additional, Sanna, Alice, additional, Epelboin, Yanouk, additional, Restrepo, Johana, additional, Davy, Damien, additional, Demar, Magalie, additional, Djossou, Félix, additional, Douine, Maylis, additional, Ardillon, Vanessa, additional, Nacher, Mathieu, additional, Musset, Lise, additional, and Roux, Emmanuel, additional

Published
2020
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157. Author response: Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

Author

Mathieu, Luana C, primary, Cox, Horace, additional, Early, Angela M, additional, Mok, Sachel, additional, Lazrek, Yassamine, additional, Paquet, Jeanne-Celeste, additional, Ade, Maria-Paz, additional, Lucchi, Naomi W, additional, Grant, Quacy, additional, Udhayakumar, Venkatachalam, additional, Alexandre, Jean SF, additional, Demar, Magalie, additional, Ringwald, Pascal, additional, Neafsey, Daniel E, additional, Fidock, David A, additional, and Musset, Lise, additional

Published
2020
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159. Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution

Author

Mosnier, Emilie, primary, Roux, Emmanuel, additional, Cropet, Claire, additional, Lazrek, Yassamine, additional, Moriceau, Olivier, additional, Gaillet, Mélanie, additional, Mathieu, Luana, additional, Nacher, Mathieu, additional, Demar, Magalie, additional, Odonne, Guillaume, additional, Douine, Maylis, additional, Michaud, Céline, additional, Pelleau, Stéphane, additional, Djossou, Félix, additional, and Musset, Lise, additional

Published
2020
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160. The Broad Clinical Spectrum of Disseminated Histoplasmosis in HIV-Infected Patients: A 30 Years’ Experience in French Guiana

Author

Couppié, Pierre, primary, Herceg, Katarina, additional, Bourne-Watrin, Morgane, additional, Thomas, Vincent, additional, Blanchet, Denis, additional, Alsibai, Kinan Drak, additional, Louvel, Dominique, additional, Djossou, Felix, additional, Demar, Magalie, additional, Blaizot, Romain, additional, and Adenis, Antoine, additional

Published
2019
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162. Emergence of Plasmodium vivax Resistance to Chloroquine in French Guiana

Author

Musset, Lise, primary, Heugas, Christophe, additional, Naldjinan, Richard, additional, Blanchet, Denis, additional, Houze, Pascal, additional, Abboud, Philippe, additional, Volney, Béatrice, additional, Walter, Gaëlle, additional, Lazrek, Yassamine, additional, Epelboin, Loïc, additional, Pelleau, Stephane, additional, Ringwald, Pascal, additional, Legrand, Eric, additional, Demar, Magalie, additional, and Djossou, Félix, additional

Published
2019
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166. Intérêt du dosage de la CRP dans la distinction précoce entre la dengue et la leptospirose en Guyane

Author

Le Turnier, Paul, Bonifay, Timothée, Mosnier, Emilie, Schaub, Roxane, Blanchet, Denis, Jolivet, Anne, Demar, Magalie Pierre, Nacher, Mathieu, Bourhy, Pascale, Djossou, Félix, Epelboin, Loïc, Centre hospitalier universitaire de Nantes (CHU Nantes), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Virales Emergentes (UMVE), Centre International de Recherches Médicales de Franceville (CIRMF), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Biologie des Spirochètes / Biology of Spirochetes, Institut Pasteur [Paris] (IP), Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Université de Guyane (UG), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), and Institut Pasteur [Paris]

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

167. Unique clone of Coxiella burnetii causing severe Q fever, French Guiana

Author

Mahamat, Aba, Edouard, Sophie, Demar, Magalie, Abboud, Philippe, Patrice, Jean-Yves, La Scola, Bernard, Okandze, Antoine, Djossou, Felix, and Raoult, Didier

Subjects
Bacterial pneumonia -- Diagnosis -- Drug therapy, Q fever -- Causes of -- Diagnosis -- Drug therapy -- Genetic aspects, Pneumonia -- Diagnosis -- Drug therapy, Rickettsia -- Health aspects -- Genetic aspects, Health
Abstract

Q fever, which is caused by the bacterium Coxiella burnetii, has rapidly emerged in French Guiana since (1). The incidence of acute Q fever in the capital, Cayenne, is one [...]

Published
2013
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168. Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana.

Author

Alsibai, Kinan Drak, Aissaoui, Houari, Adenis, Antoine, Bourne-Watrin, Morgane, Djossou, Felix, Epelboin, Loïc, Blanchet, Denis, Demar, Magalie, Couppié, Pierre, and Nacher, Mathieu

Subjects
HISTOPLASMOSIS diagnosis, BRONCHOALVEOLAR lavage, HISTOPLASMA capsulatum, IMMUNOCOMPETENCE, CYTOLOGY
Abstract

Disseminated histoplasmosis is a major cause of mortality in HIV-infected patients. Rapid and efficient diagnosis of Histoplasma capsulatum is crucial. Cytopathology is available in most hospitals and represents a rapid diagnostic alternative. In this study, we reviewed 12 years of experience to describe the cytology of histoplasmosis diagnosed by bronchoalveolar lavage (BAL) in relation to patient characteristics. BAL-diagnosed pulmonary histoplasmosis concerned 17 patients (14 HIV+). BAL cellularity ranged from 76,000 to 125,000 cells/mL in HIV patients, and 117,000 to 160,000 cells/mL in non-HIV patients. Macrophages predominated in all HIV patients (from 60% to 88%), lymphocytic infiltrates ranged from 5% to 15%, and neutrophils were very heterogeneous (from 2% to 32%). The number of H. capsulatum at hot spots seemed greater in HIV-infected than in immunocompetent patients (9 to 375 vs. 4 to 10) and were inversely proportional to the CD4 counts. Yeasts were both intracellular and extracellular in 85.7% of the HIV patients. This is the most comprehensive series detailing the cytological aspects of BAL in the diagnosis of H. capsulatum, focusing on the number of yeasts and their clustering pattern. The cytological examination of the Gomori-Grocott-stained BAL allows a reliable diagnosis of histoplasmosis. [ABSTRACT FROM AUTHOR]

Published
2021
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170. Hyperparasitaemia during bouts of malaria in French Guiana

Author

Carme Bernard and Demar Magalie

Subjects
Malaria, Plasmodium falciparum, Plasmodium vivax, Hyperparasitaemia, Severe malaria, French Guiana, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background High circulating parasite load is one of the WHO criteria for severe falciparum malaria. During a period of 11 years (2000–2010), the frequency of hyperparasitaemia (HP) (≥4% infected erythrocytes) during bouts of malaria due to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae in patients referred to Cayenne General Hospital (CGH) in French Guiana and the frequency of their admission to the Intensive Care Unit (ICU) were evaluated. Methods A mean of 1,150 malaria cases were referred to the Parasitology Laboratory of CGH each year over the last decade. During this period, malaria diagnostic (microscopy) and parasitaemia evaluation have remained unchanged: determination of the parasitized erythrocytes percentage with asexual forms on thin blood smears for all cases of parasitaemia exceeding 0.1%. Patients admitted to the ICU can be counted by origin of the request for malaria testing. All the data collected retrospectively were anonymized in a standardized case report form and in database. Results Between 2000 and 2010, 12,254 bouts of malaria were confirmed at the Parasitology Laboratory of CHG: P. vivax: 56.2%, P. falciparum: 39.5%, co-infection with both species: 3.4%, P. malariae: 0.9%. HP was observed in 262 cases, at a frequency of 4.9% for P. falciparum and only 0.041% for P. vivax, with no recorded cases for P. malariae. The need for intensive care was correlated with P. falciparum parasite load: 12.3% of cases for parasitaemia of 4-9%, 21.2% for parasitaemia 10-19%, 50% for parasitaemia 20-29% and 77.8% for parasitaemia ≥30% (n=9). The patient with the highest parasitaemia (75% infected erythrocytes with asexual form) presented a major concomitant lupus flare-up treated with corticoids. He survived without obvious sequelae. Conclusions In French Guiana during bouts of malaria, HP was observed at a frequency of ~ 5% for P. falciparum and two orders of magnitude less frequent for P. vivax. HP is a severity criterion for falciparum malaria in this endemic area. However, two of the patients with HP ≥30% were not admitted to the ICU and sequel-free cure in malaria patients with 75% parasitaemia is, therefore, possible.

Published
2013
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171. Histoplasmose disseminada na Am?rica do Sul, o elefante invis?vel Central e o ponto cego letal de organiza??es internacionais de sa?de

Author

Nacher, Mathieu, Adenis, Antoine, Arathoon, Eduardo, Samayoa, Blanca, Lau-Bonilla, Dalia, Gomez, Beatriz L, Tobon, Angela, Caceres, Diego, Silva, Silvia Marques da, Costa, Maurimelia Mesquita da, Zancope, Rosely, Leit?o, Terezinha Silva, Gomes, Margarete do Socorro Mendonca, Lima, Ivina Lopes, Leite, Rosilene Malcher, Vreden, Stephen, Eer, Marja Van, Mac Donald, Sigrid, Hermelin, Sandra, Demar, Magalie, Blanchet, Denis, Djossou, Felix, Vantilcke, Vincent, Panizo, Maria Mercedez, Dolande, Maribel, Canteros, Christina, Lacerda, Marcus, Couppi?, Pierre, and Restrepo, Angela

Subjects
Diagnostic Tests, Routine, S?ndrome de Imunodefici?ncia Adquirida, Immunology, Central America, HIV Infections, South America, Survival Analysis, Am?rica do Sul, Infec??es Oportunistas Relacionadas com a AIDS, Infectious Diseases, Prevalence, Mortalidade, Humans, Immunology and Allergy, Histoplasmosis, Ag?ncias Internacionais, Histoplasmose / epidemiologia
Abstract

Centre Hospitalier de Cayenne. Centre d Investigation Clinique Antilles. Guyane, Cayenne. Centre Hospitalier de Cayenne. Centre d Investigation Clinique Antilles. Guyane, Cayenne. Asociaci?n de Salud Integral. Cl?nica Familiar "Luis Angel Garc?a". Guatemala. Asociaci?n de Salud Integral. Cl?nica Familiar "Luis Angel Garc?a". Guatemala. Asociaci?n de Salud Integral. Cl?nica Familiar "Luis Angel Garc?a". Guatemala. Universidad Rosario. School of Medicine and Health Sciences. Bogot? and Corporacion para Investigationnes Biologicas. Bogot?, Colombia. Universidad Rosario. School of Medicine and Health Sciences. Bogot? and Corporacion para Investigationnes Biologicas. Bogot?, Colombia Universidad Rosario. School of Medicine and Health Sciences. Bogot? and Corporacion para Investigationnes Biologicas. Bogot?, Colombia. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Funda??o Oswaldo Cruz. Instituto de Pesquisa Cl?nica Evandro Chagas. Laborat?rio de Micologia. Rio de Janeiro, RJ, Brazil. Federal University of Cear?. Fortaleza, CE, Brazil. Laborat?rio Central de Sa?de P?blica do Amap?. Macap?, AP, Brazil. Laborat?rio Central de Sa?de P?blica do Amap?. Macap?, AP, Brazil. Laborat?rio Central de Sa?de P?blica do Amap?. Macap?, AP, Brazil. Academic Hospital Paramaribo. Suriname. Diakonessenhuis. Utrecht, KE. Academic Hospital Paramaribo. Suriname. Academic Hospital Paramaribo. Suriname. Universit? de Guyane. Ecosyst?mes Amazoniens et Pathologie Tropicale. French Guiana. Universit? de Guyane. Ecosyst?mes Amazoniens et Pathologie Tropicale. French Guiana. Universit? de Guyane. Ecosyst?mes Amazoniens et Pathologie Tropicale. French Guiana. Centre Hospitalier de l Ouest Guyanais. Service de M?decine. French Guiana. Instituto Nacional de Higiene Rafael Rangel. Departamento de Micolog?a. Caracas, Venezuela. Instituto Nacional de Higiene Rafael Rangel. Departamento de Micolog?a. Caracas, Venezuela. INEI-ANLIS "Dr Carlos G. Malbran". Buenos Aires, Argentina. Funda??o Oswaldo Cruz. Instituto Le?nidas e Maria Deane. Rio de Janeiro, RJ, Brazil. Universit? de Guyane. Ecosyst?mes Amazoniens et Pathologie Tropicale. French Guiana. Universidad Rosario. School of Medicine and Health Sciences. Bogot? and Corporacion para Investigationnes Biologicas. Bogot?, Colombia.

Published
2016

172. Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French Guiana

Author

Carme, Bernard, Demar, Magalie, Ajzenberg, Daniel, and Darde, Marie Laure

Subjects
Company distribution practices, Toxoplasmosis -- Causes of, Toxoplasmosis -- Diagnosis, Toxoplasmosis -- Distribution, Toxoplasma -- Physiological aspects, Toxoplasma -- Distribution, Toxoplasma -- Research
Abstract

French Guiana is a French territory in South America; the Amazon rain forest covers 92% of the territory. Toxoplasmosis is a cosmopolitan parasitic disease. It is usually benign in patients [...]

Published
2009

173. Comparison of Mycobacterium ulcerans (Buruli ulcer) and Leptospira sp. (Leptospirosis) dynamics in urban and rural settings

Author

Combe, Marine, Gozlan, Rodolphe Elie, Jagadesh, Soushieta, Velvin, Camilla Jensen, Ruffine, Rolland, Demar, Magalie Pierre, Couppié, Pierre, Djossou, Félix, Nacher, Mathieu, Epelboin, Loïc, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and ANR-17-CE35-0006,PRIME,PRédire la niche écologique de souches Infectieuses de pathogènes humains comme un facteur déterminant dans l'éMErgence des maladies infectieuses(2017)

Subjects
Rural Population, Bacterial Diseases, Urban Population, RC955-962, Pathology and Laboratory Medicine, Microbiology, Urban Environments, Spatio-Temporal Analysis, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Arctic medicine. Tropical medicine, Zoonoses, Environmental Microbiology, Medicine and Health Sciences, Humans, Leptospirosis, Microbial Pathogens, Petrology, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Leptospira, Sedimentary Geology, Mycobacterium ulcerans, Bacteria, Ecology and Environmental Sciences, Organisms, Biology and Life Sciences, Geology, Tropical Diseases, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Terrestrial Environments, French Guiana, Bacterial Pathogens, Actinobacteria, Infectious Diseases, Medical Microbiology, Earth Sciences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Sediment, Seasons, Public aspects of medicine, RA1-1270, Pathogens, Research Article, Neglected Tropical Diseases
Abstract

Background Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to variability in environmental pathogen dynamics and can facilitate their transmission from natural reservoirs to new susceptible hosts. Whilst the environmental dynamics of aquatic bacteria are directly linked to seasonal changes of their habitat they also rely on the ecological processes underpining their transmission. However data allowing the comparison of these ecological processes are lacking. Here we compared the environmental dynamics of generalist and vector-borne aquatic bacterial pathogens in the same unit of time and space, and across rural and urban habitats in French Guiana (South America). Principal findings Using Leptospira sp. and Mycobacterium ulcerans we performed an environmental survey that allowed the detection of both pathogens in urban vs. rural areas, and during rainy vs. dry weather conditions. All samples were subjected to qPCR amplifications of LipL32 (Leptospira sp.) and IS2404 and KR (M. ulcerans) genetic markers. We found (i) a greater presence of M. ulcerans in rural areas compared with Leptospira sp., (ii) that modified urban environments were more favourable to the establishment of both pathogens, (iii) that Leptospira sp. presence was enhanced during the rainy season and M. ulcerans during the dry period, and (iv) differences in the spatial distribution of both bacteria across urban sites, probably due to the mode of dissemination of each pathogen in the environment. Conclusions We propose that in French Guiana simplified and modified urban ecosystems might favour leptospirosis and Buruli ulcer emergence and transmission. Moreover, disease risk was also constrained by seasonality. We suggest that the prevention of aquatic bacterial disease emergence in impoverished urban areas of developing countries would benefit from seasonal diseases targeted surveys, which would maximise limited budgets from cash-strapped health agencies., Author summary Many emerging pathogens are zoonotic and transmit from their abiotic reservoir to wild animals, domesticated animals and humans. It is now well known that environmental changes lead to variability in their dynamics in the environment and contribute to changes in the infectious risk. Many aquatic bacteria are responsable for major public health concerns, and more importantly in developing countries where access to drinking-water and sanitation is often limited. Whilst their environmental dynamics are directly linked to seasonal changes of their habitat, they also rely on the ecological processes underpining their transmission, i.e. directly transmitted vs. vector-borne. However, few studies have compared such environmental dynamics despite the fact that it would help to better characterise the infectious risk in the environment, as well as to better monitor the emergence of infectious diseases. Our aim was to provide data on the prevalence of generalist vs. vector-borne aquatic bacterial pathogens in the environment that would further allow the comparison of their environmental dynamics in the same unit of time and space, and across rural and urban habitats. We showed that urbanization and seasonality are two important factors underlying Buruli ulcer and leptospirosis disease emergence in French Guiana (South America), and propose that the mode of transmission of such environmental pathogens might have a detrimental role in disseminating the infectious agent in the environment.

Published
2018

174. Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison

Author

Epelboin, Loïc, Caumes, Eric, Guermonprez, Geraldine, Leturcq, France, Clarke, Peter, Nacher, Mathieu, Adenis, Antoine, Huber, Florence, Hallet, Edouard, Abboud, Philippe, Mosnier, Emilie, Bideau, Bastien, Marty, Christian, Lucarelli, Aude, Morel, Vanessa, Lacapère, François, Couppié, Pierre, Paraskevis, Dimitrios, Valdes, Audrey, Walter, Gaelle, Vesin, Guillaume, Melzani, Alessia, Blanchet, Denis, Blaise, Nicaise, Demar, Magalie Pierre, Djossou, Félix, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fondation Maison des Champs, Biochimie et Génétique Moléculaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Croix-rouge française [Cayenne, Guyane Fraçaise], Service de Dermatologie, Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française], Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Service de Pharmacie [Cayenne, Guyane Française], Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne, Guyane] (COREVIH), and Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424

Subjects
Adult, Male, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, Primaquine, lcsh:RC955-962, 030231 tropical medicine, Plasmodium vivax, Context (language use), World health, lcsh:Infectious and parasitic diseases, Antimalarials, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, parasitic diseases, Epidemiology, Malaria, Vivax, Secondary Prevention, Humans, Medicine, lcsh:RC109-216, 030212 general & internal medicine, Relapse, ComputingMilieux_MISCELLANEOUS, Survival analysis, Dose-Response Relationship, Drug, biology, business.industry, Research, Middle Aged, biology.organism_classification, medicine.disease, Malaria, French Guiana, 3. Good health, Infectious Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Tropical medicine, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Parasitology, business, medicine.drug
Abstract

International audience; BACKGROUND:The preventive treatment of Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania. Since 2006, CDC recommends the use of primaquine at 30 mg/day for 14 days. In France, all cases of malaria due to P. vivax are treated with 30 mg of primaquine. This systematically increased dosage needs to be evaluated according to epidemiological context. The aim of the study was to compare relapses after 14 days of primaquine at 15 or 30 mg/day.METHODS:All patients treated with primaquine after a vivax malaria episode in French Guiana, between 1 January, 2007 and 1 August, 2016, were studied. Based on the compulsory hospital pharmacy forms for primaquine delivery, adult patients who received 15 or 30 mg of primaquine during 14 days for hypnozoite eradication were included. The recommended dose was initially 15 mg and was changed to 30 mg in 2011. Vivax malaria recurrences within 2 months after primaquine treatment, and vivax malaria recurrences 2-6 months after primaquine in each treatment group were analysed using survival analysis at 2, 3 and 6 months.RESULTS:Out of 544 patients included, 283 received 15 mg/day and 261 received 30 mg/day of primaquine. At 2 and 3 months after primaquine treatment, the number of recurrences was 7 (2.5%) and 19 (7.3%), and 9 (3.4%) and 15 (5.3%), in the 15 and 30 mg groups (p = 0.51 respectively 0.35), respectively. Within 3 months, the median time to recurrence was 2.05 months in the 15 and 30 mg groups. At 6 months after primaquine treatment, the number of recurrences was 25 (8.8%) and 31 (11.9%) at 15 and 30 mg, respectively (p = 0.24). The median time to recurrence was 2.38 months at 15 mg/day and of 2.64 months at 30 mg/day.CONCLUSIONS:There were no significant differences between primaquine at 15 or 30 mg/day for 14 days in the prevention of P. vivax relapses at 2, 3 and 6 months after primaquine treatment in French Guiana

Published
2018

175. Central nervous system histoplasmosis in AIDS: a case series in French Guiana

Author

Epelboin, Loïc, Dione, Aïda, Blanchet, Denis, Nacher, Mathieu, Demar, Magalie Pierre, Couppié, Pierre, Djossou, Félix, Adenis, Antoine, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Université Bordeaux Segalen - Bordeaux 2, Laboratoire Hospitalier et Universitaire Parasitologie Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Epidémiologie des parasitoses et mycoses tropicales, Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française], Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

177. Cryptosporidiosis Outbreak in Immunocompetent Children from a Remote Area of French Guiana

Author

Mosnier, Emilie, Martin, Noémie, Razakandrainibe, Romy, Dalle, Frédéric, Roux, Guillaume, Buteux, Arnaud, Favennec, Loïc, Brousse, Paul, Guarmit, Basma, Blanchet, Denis, Epelboin, Loïc, Girouin, Camille, Martin, Elise, Djossou, Félix, Nacher, Mathieu, Demar, Magalie Pierre, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Laboratoire de parasitologie mycologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Département des Centres Délocalisés de Prévention et de Soins, Agence Régionale de la Santé, Cayenne, Guyane française (ARS), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne, Guyane] (COREVIH)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; In September 2014, an increase in the number of Cryptosporidium spp. gastrointestinal tract infections was reported over a 6-month period among children living in a remote area along the Maroni River in French Guiana. Children presented gastroenteritis symptoms with Cryptosporidium-positive stools. Questionnaires were administered and stool examinations were controlled 3 months after the onset of symptoms. Data collection included demographics, food consumption, river behavior, symptoms, and outcome. Stool specimens were tested using microscopy and polymerase chain reaction. Samples from the water systems were examined for turbidity and culture for bacteria. Data from the reference laboratory were analyzed to calculate the median cryptosporidiosis incidence among immunocompetent patients from 2008 to 2015. Data on gastroenteritis cases reported by the Delocalized Center for Prevention and Care in the area were also collected. We report a cluster of 14 cases. All cases were children, aged between 4.5 and 38 months. Seven reported moderate to severe dehydration and required hospitalization. Speciation and microbiological typing revealed the cluster strain was Cryptosporidium hominis subtype IbA10G2 but C. hominis IbA9G2 and IbA15G1 strains were also identified. The median incidence in French Guiana was 5.8 cases per year before the outbreak. The first cases of the cluster appeared in the dry season. We describe the clinical features, epidemiology, and state of current investigations for the largest documented outbreak of cryptosporidiosis in French Guiana.

Published
2018

178. Angiostrongyliasis due to A. cantonensis: first evidence in French Territories of America& an up-date in all French Overseas Territories

Author

Dard, C., Nguyen, D., Miossec, C., Tessier, E., de Meuron, K., Harrois, D., Mattera, D., Epelboin, Loïc, Demar, Magalie Pierre, Blanchet, Denis, Elenga, N., Defo, A., Nicolas, M., Desprez, P., Rulquin, L., Tournier, S., Aubert, L., Traversier, N., Jaffar Bandjee, M.C., Belmonte, O., Miltgen, G., Collet, L., Blondé, R., Chamouine, Abdourahim, Benoit-Cattin, T., Olivier, C., Giard, M., Guerin, A., Ghawche, F., Darteyre, S., Larre, P., Sookhareea, C., Pasche, J., Oehler, E., Delvallez, G., Gourinat, A.C., Lastère, S., Desbois-Nogard, N., Matillon, Mirlène, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Laboratoire Hospitalier et Universitaire Parasitologie Mycologie, and Centre Hospitalier de Mayotte

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

179. First established case of Angiostrongylus cantonensis meningomyelitis in French Guiana, 2017

Author

Defo, A, Lachaume, N, Cuadro-Alvarez, Emma, Maniassom, Chimène, Martin, M, Njuieyon, Falucar, Hennaf, F, Mrsic, Yajaira, Brunnelin, A, Epelboin, Loïc, Blanchet, D, Desbois-Nogard, Nicole, Qvarnstrom, Yvonne, Demar, Magalie Pierre, Dard, C, Elenga, Narcisse, Service de Pédiatrie [Cayenne, Guyanne Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), Université de Guyane (UG), Laboratoire de Parasitologie-Mycologie-Sérologies Bactériennes et Parasitaires [CHU de la Martinique], Centre Hospitalier Universitaire de la Martinique - CHU Martinique, Department of parasitic diseases, Centers for Disease Control, and Latour, Marie

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

180. Cryptosporidiosis outbreak on children in Amazonia

Author

Mosnier, Emilie, Martin, N, Razakandrainibe, Romy, Dalle, F, Roux, G, Buteux, Arnaud, Favennec, L, Brousse, P, Guarmit, P, Blanchet, D, Epelboin, Loïc, Girouin, C, Martin, E, Djossou, Félix, Nacher, Mathieu, Demar, Magalie Pierre, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Hôpital Charles Nicolle [Rouen], Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Latour, Marie, and Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

181. Acute Amazon toxoplasmosis in immunocompetent patients: a descriptive study of 42 cas in French Guiana

Author

Labaudinière, Aude, Demar, Magalie Pierre, Davy, Damien, Epelboin, Loïc, Carod, Jean-François, Brousse, Paul, Mosnier, Emilie, Matillon, Mirlène, Laboratoire Hospitalier et Universitaire Parasitologie Mycologie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Unité des Maladies Infectieuses et Tropicales (UMIT), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Département des Centres Délocalisés de Prévention et de Soins, and Université de Guyane (UG)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

182. <em>Histoplasma capsulatum</em> and <em>Histoplasmosis : </em> Current Concept for the Diagnosis

Author

Demar, Magalie, Guemas, Emilie, and Sobanska, Loic

Subjects
Medical
Abstract

Histoplasmosis is a global deep mycosis caused by Histoplasma capsulatum (Hc), a dimorphic fungus. It exists on two main varieties Hc capsulatum and Hc duboisii that could be distinguished by their epidemiology, their clinical presentation, and the morphological aspect of the fungus at direct examination of the sample. Laboratory diagnosis of Hc remains a real challenge as it required experience and equipment. Through a general review of literature, the different diagnosis tools for Histoplasma sp. are analyzed, and strengths and weaknesses are pointed according to the context-based value. Isolation of Hc on culture is the gold standard for diagnosis of histoplasmosis. However, it remains less sensitive (sensitivity: up to 77%) and implies long time to result, which can be inappropriate or in adapted for an emergency diagnosis. So, nonculture methods as antigen testing, serology, and molecular biology become available and allow a rapid diagnosis. However, the optimal diagnostic method depends on many parameters as the very wide range of symptomatology, the immune status. Indeed, Ag detection is the best diagnosis tool for PHD (sensitivity: 92–95%) and SCN histoplasmosis (sensitivity: 66%) and serology for the subacute/chronic form (sensitivity: 85–93%). Thus, the clinico-biological dialog is essential, and histoplasmosis management includes an integrated medical approach.

Published
2018

184. Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

Author

Chavy, Agathe, primary, Ferreira Dales Nava, Alessandra, additional, Luz, Sergio Luiz Bessa, additional, Ramírez, Juan David, additional, Herrera, Giovanny, additional, Vasconcelos dos Santos, Thiago, additional, Ginouves, Marine, additional, Demar, Magalie, additional, Prévot, Ghislaine, additional, Guégan, Jean-François, additional, and de Thoisy, Benoît, additional

Published
2019
Full Text
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186. The Fight against HIV-Associated Disseminated Histoplasmosis in the Americas: Unfolding the Different Stories of Four Centers

Author

Nacher, Mathieu, primary, Leitao, Terezinha Silva, additional, Gómez, Beatriz L., additional, Couppié, Pierre, additional, Adenis, Antoine, additional, Damasceno, Lisandra, additional, Demar, Magalie, additional, Samayoa, Blanca, additional, Cáceres, Diego H., additional, Pradinaud, Roger, additional, Sousa, Anastacio de Queiroz, additional, Arathoon, Eduardo, additional, and Restrepo, Angela, additional

Published
2019
Full Text
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187. Incidence and Trends in Immune Reconstitution Inflammatory Syndrome Associated With Histoplasma capsulatum Among People Living With Human Immunodeficiency Virus: A 20-Year Case Series and Literature Review

Author

Melzani, Alessia, primary, de Reynal de Saint Michel, Regis, additional, Ntab, Balthazar, additional, Djossou, Felix, additional, Epelboin, Loic, additional, Nacher, Mathieu, additional, Blanchet, Denis, additional, Demar, Magalie, additional, Couppie, Pierre, additional, and Adenis, Antoine, additional

Published
2019
Full Text
View/download PDF

190. Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: A systematic review of diagnostic accuracy studies

Author

Nacher, Mathieu, primary, Blanchet, Denis, additional, Bongomin, Felix, additional, Chakrabarti, Arunaloke, additional, Couppié, Pierre, additional, Demar, Magalie, additional, Denning, David W., additional, Djossou, Félix, additional, Epelboin, Loïc, additional, Govender, Nelesh, additional, Leitão, Terezinha, additional, Mac Donald, Sigrid, additional, Mandengue, Christine, additional, Marques da Silva, Silvia Helena, additional, Oladele, Rita, additional, Panizo, Maria Mercedes, additional, Pasqualotto, Alessandro, additional, Ramos, Ruth, additional, Swaminathan, Subramanian, additional, Rodriguez-Tudela, Juan Luis, additional, Vreden, Stephen, additional, Zancopé-Oliveira, Rosely, additional, and Adenis, Antoine, additional

Published
2018
Full Text
View/download PDF

191. Identification of Leishmania by MALDI-TOF mass spectrometry using a free web-based application and a dedicated mass spectral library

Author

Lachaud, Laurence, Fernández-Arévalo, Anna, Normand, Anne Cécile, Lami, Patrick, Nabet, Cécile, Donnadieu, Jean Luc, Piarroux, Martine, Djenad, Farid, Cassagne, Carole, Ravel, Christophe, Tebar, Silvia, Llovet, Teresa, Blanchet, Denis, Demar, Magalie, Harrat, Zoubir, Aoun, Karim, Bastien, Patrick, Muñoz, Carmen, Gallego, Montserrat, Piarroux, Renaud, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Aix Marseille Université (AMU), Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques (IP-TPT), Service de Santé des Armées-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Centre National de Référence des Leishmanioses [CHRU Montpellier] (CNR-L), Université de Montpellier (UM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Biologie, Génétique et Pathologie des Pathogènes Eucaryotes (MIVEGEC-BioGEPPE), Pathogènes, Environnement, Santé Humaine (EPATH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Institut Pasteur d'Algérie, Réseau International des Instituts Pasteur (RIIP), Université des Sciences et de la Technologie Houari Boumediene [Alger] (USTHB), Laboratoire de Parasitologie Médicale, Biotechnologies et Biomolécules (LR11IPT06), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de référence de la Toxoplasmose (CNRT), Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), and Assistance Publique - Hôpitaux de Marseille (APHM)

Subjects
parasitic diseases, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Human leishmaniasis are widely spread diseases with different clinical forms caused by about 20 species within the Leishmania genus. Leishmania species identification is relevant for therapeutic management and prognosis, especially for cutaneous and muco-cutaneous forms. Several methods are available to identify Leishmania species from culture, but they have not been standardized for the majority of the currently described species, with the exception of MultiLocus Enzyme Electrophoresis. Moreover, these techniques are expensive, time-consuming and not available in all laboratories. Within the last decade, mass spectrometry (MS) has been adapted for microorganism identification, including Leishmania However, no commercial reference mass spectral database is available. In this study, a reference mass spectral library (MSL) for Leishmania isolates, accessible through a free web-based application (mass spectral identification, MSI), was constructed and tested. It includes mass spectral data for 33 different Leishmania species, including species that infect humans, animals and phlebotomine vectors. Four laboratories on two continents evaluated MSI performance using 268 samples of which 231 were Leishmania strains. All Leishmania strains, but one, were correctly identified at least at the complex level. A risk of species misidentification within the L. donovani, L. guyanensis and L. braziliensis complexes was observed, as already reported with other techniques. The tested application was reliable, with identification results comparable to those obtained with reference methods, but with a more favorable cost-efficiency ratio. This free online identification system relies on a scalable database and can be implemented directly in the user's computers.

Published
2017

192. Efficacité thérapeutique de la chloroquine dans le traitement des accès palustres simples à Plasmodium vivax en Guyane

Author

Epelboin, Loïc, Musset, L., Heugas, C., Naldjinan, R., Blanchet, D, Houze, P., Abboud, Philippe, Ringwald, P., Legrand, Eric, Demar, Magalie Pierre, Felix, D., Centre Hospitalier de Mayotte, Université de Guyane (UG), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Réseau International des Instituts Pasteur (RIIP), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

193. Primaquine 30 mg/j versus 15 mg/j pendant 14 j pour la prévention des reviviscences de Plasmodium vivax de l’adulte dans une région d’Amérique : où en sommes-nous ? (MIG-07)

Author

Valdes, A., Epelboin, Loïc, Mosnier, Emilie, Walter, G., Vesin, Guillaume, Abboud, Philippe, Blanchet, Denis, Blaise, N., Demar, Magalie Pierre, Djossou, Félix, Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Unité des Maladies Infectieuses et Tropicales (UMIT), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

194. Formes graves de paludisme à Plasmodium vivax : caractéristiques sociologiques, cliniques et biologiques associées à l’anémie profonde (MIG-10)

Author

Baha, L., Blanchet, Denis, Elenga, N., Egmann, G., Carme, B., Djossou, Félix, Demar, Magalie Pierre, Epelboin, Loïc, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Université de Guyane (UG), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

195. La fièvre Q chronique en Guyane française: une entité méconnue

Author

Sanderink, D, Melenotte, C., Walter, G, Bidaud, B, Jauréguiberry, S., Mahamat, A., Demar, Magalie Pierre, Abboud, P., Djossou, Félix, Epelboin, Loïc, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Lab-STICC_UBO_CID_SFIIS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Lebanese Univ, EC2M, Fac Sci 2, Campus Pierre Gemayel, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

196. La fièvre Q chronique en Amérique latine : une entité méconnue

Author

Jauréguiberry, S., Mahamat, A., Demar, Magalie Pierre, Sanderink, D., Melenotte, C., Walter, G., Bidaud, Bastien, Abboud, Philippe, Djossou, Félix, Epelboin, Loïc, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Université de Guyane (UG), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

197. Cryptococcose disséminée : explorations immunitaires chez 6 patients non infectés par le VIH (PARA-02)

Author

Goupil de Bouillé, Jeanne, Epelboin, Loïc, Djossou, Félix, Blanchet, Denis, Aznar, Christine, Henaff, F., Lanternier, Fanny, Guery, Romain, Puel, Anne, Demar, Magalie Pierre, Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Unité des Maladies Infectieuses et Tropicales (UMIT), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

198. Primaquine 30 mg/j vs 15 mg/j pendant 14 j pour la prévention des reviviscences de Plasmodium vivax de l’adulte dans une région d’Amérique : où en sommes-nous ?

Author

Valdes, A, Epelboin, Loïc, Mosnier, E., Walter, G, Vesin, G, Abboud, P., Blanchet, D., Blaise, N, Demar, Magalie Pierre, Djossou, Félix, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Université de Guyane (UG), Lebanese Univ, EC2M, Fac Sci 2, Campus Pierre Gemayel, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

199. Human leptospirosis in French Guiana: current knowledge and perspectives

Author

Epelboin, Loïc, Le Turnier, Paul, Picardeau, Mathieu, Schaub, Roxane, Petit-Sinturel, Marion, Villemant, Nicolas, Trombert-Paolantoni, Sabine, Berlioz-Arthaud, Alain, Bisser, Sylvie, Mosnier, Emilie, Ardillon, Vanessa, Jolivet, Anne, Demar, Magalie, Nacher, Mathieu, Bourhy, Pascale, Djossou , Felix, Université de Guyane (UG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence de la Leptospirose - National Reference Center Leptospirosis (CNR), Institut Pasteur [Paris] (IP), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Cellule Inter Régionale d'Epidémiologie des Antilles - Guyane, Institut de Veille Sanitaire (INVS), Université Paris 1 Panthéon-Sorbonne - UFR Géographie (UP1 UFR08), Université Paris 1 Panthéon-Sorbonne (UP1), Laboratoire CERBA [Saint Ouen l'Aumône], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Département des Centres Délocalisés de Prévention et de Soins, Centre Hospitalier de l'Ouest Guyanais, Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH Guyane), Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Institut Pasteur [Paris], and Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]

Subjects
Leptospira, Epidemiology, [SDV]Life Sciences [q-bio], Neglected tropical disease, Leptospirose, Maladie tropicale négligée, French Guiana, Épidémiologie, Zoonosis, Guyane française // Keywords: Leptospirosis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Guyane française, Zoonose, Leptospirosis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Leptospirosis is a cosmopolitan zoonosis caused by the bacteria of the genus Leptospira. The warm and wet climate of the intertropical zone is particularly favorable with its expansion. In French Guiana, a French territory located at the North-East of the South American continent in Amazonian area, it seems to be rare. The objective of this article is to make the inventory of current knowledge on the epidemiology of human leptospirosis in French Guiana, and to discuss the prospects concerning this disease and improve its surveillance. Publications on leptospirosis in French Guiana are rare and old, and date from 1940 to 1995. The annual reports of the National Reference Centre of Leptospirosis (NRC, Pasteur Institute) show a quite stable annual number of cases, varying from 6 to 18 between 1996 and 2012, depending on the year, with a significant increase from 2013 to 2015, respectively 36, 92 and 67 cases a year. A retrospective study conducted recently on the cases which occurred between 2007 and 2014 with very strict inclusion criteria, identified 72 cases on the territory, among whom 12 (16.7%) severe cases and 3 (4.2%) deaths. The disease affects mainly men (86.1%) aged between 20 and 49 years (63.9%). It is probable that leptospirosis is a neglected disease in the region, due to the absence of quickly available diagnostic tools, the lack of awareness of clinicians on this pathology, and the existence of many other infectious agents with similar clinical presentations during acute episodes (such as malarias, arboviruses, Q fever and Amazonian toxoplasmosis). The implementation of larger studies is necessary to know the true burden of this disease in French Guiana., La leptospirose est une zoonose cosmopolite causée par les bactéries du genre Leptospira. Le climat chaud et humide de la zone intertropicale est particulièrement propice à son expansion. En Guyane, département français situé au nord-est du continent sud-américain, en région amazonienne, elle semble rare. L’objectif de cet article est de récapituler l’état des connaissances actuelles sur l’épidémiologie de leptospirose humaine en Guyane et de discuter les perspectives pour en améliorer la surveillance.Les publications sur la leptospirose en Guyane sont rares et anciennes, datant des années 1940-1995. Les rapports annuels du Centre national de référence de la leptospirose (CNR, Institut Pasteur de Paris) montrent un nombre annuel de cas assez stable entre 1996 et 2012, variant de 6 à 18 selon les années, avec une augmentation importante de 2013 à 2015 : respectivement 36, 92 et 67 cas par an. Une étude rétrospective menée récemment sur les cas survenus entre 2007 et 2014, identifiés avec des critères diagnostiques très stricts, a comptabilisé 72 cas sur le département, parmi lesquels 12 (16,7%) cas graves et 3 (4,2%) décès. La maladie touchait principalement des hommes (86,1%) âgés de 20 à 49 ans (63,9%).Il est probable que la leptospirose soit une maladie négligée dans la région, du fait de l’absence d’outils diagnostiques rapidement disponibles, de la méconnaissance des cliniciens de cette pathologie et de la présence de nombreuses autres pathologies à symptômes cliniques similaires en phase aiguë (paludismes, arboviroses, fièvre Q, toxoplasmose amazonienne). La mise en place d’études de plus grande ampleur est nécessaire pour connaître le véritable impact de cette maladie en Guyane.

Published
2017

200. In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs

Author

Simon, Stéphane, Nacher, Mathieu, Demar, Magalie, Carme, Bernard, Couppié, Pierre, Scotto, Camille Inès, Burger, Pauline, Khodjet el Khil, Mehdi, Ginouves, Marine, Prévôt, Ghislaine, Blanchet, Denis, Delprete, Piero, Fernandez, Xavier, Groupement de Recherche Eau, Sol, Environnement (GRESE), Université de Limoges (UNILIM), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), Epidémiologie des parasitoses et mycoses tropicales, Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Institut de Chimie de Nice (ICN), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Tissus animaux, nutrition, digestion, écosystème et métabolisme (TANDEM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-INP. Ecole Nationale Supérieure Agronomique de Toulouse, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre National de Référence Leishmania [Cayenne, Guyanne Française] (Laboratoire Associé), Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Guyanais de Dermatologie Tropicale, E.A. 2188, This work was supported by the University of French Guiana and the Ministère Français de l’Enseignement Supérieur et de la Recherche Scientifique, the Conseil Régional de la Guyane and the European Union (FEDER-Presage N° 31454), and the 'Investissement d’Avenir' grant managed by Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière]

Subjects
0301 basic medicine, Meglumine antimoniate, 030231 tropical medicine, 030106 microbiology, Paromomycin, Drug resistance, Pharmacology, Biology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Virology, Amphotericin B, parasitic diseases, medicine, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, ComputingMilieux_MISCELLANEOUS, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Miltefosine, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Leishmaniasis, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, medicine.disease, biology.organism_classification, Leishmania braziliensis, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Infectious Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.drug, Pentamidine
Abstract

International audience; Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous. One isolate exhibited high IC50 values for almost all drugs tested. Pentamidine, which is the first-line treatment in French Guiana, showed efficacy at very low doses (mean of 0.0038 μg/mL). The concordance of the in vitro pentamidine results with the patients' clinical outcomes was 94% (K = 0.82).

Published
2016

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