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5,982 results on '"Chun Xiang"'

151. Apple SINA11‐JAZ2 module is involved in jasmonate signaling response.

Author

Ai, Di, Zhao, Lei, You, Chun‐Xiang, Han, Yuepeng, and An, Jian‐Ping

Subjects
JASMONATE, ANTHOCYANINS, UBIQUITIN ligases
Abstract

This article, published in the Journal of Integrative Plant Biology, explores the role of the E3 ubiquitin ligase MdSINA11 in the ubiquitination and degradation of the jasmonate ZIM domain protein MdJAZ2 in apple plants. The study reveals that MdSINA11 targets MdJAZ2 for degradation through the 26S proteasome pathway, initiating jasmonate signaling and anthocyanin biosynthesis. The findings provide insights into the post-translational regulatory mechanism of the jasmonate signaling pathway and its role in plant growth and development. The research was supported by various grants and the authors declare no conflicts of interest. [Extracted from the article]

Published
2024
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153. SPEEDING Up the Metabolism in E-commerce by Reinforcement Mechanism DESIGN

Author

He, Hua-Lin, Pan, Chun-Xiang, Da, Qing, Zeng, An-Xiang, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Brefeld, Ulf, editor, Curry, Edward, editor, Daly, Elizabeth, editor, MacNamee, Brian, editor, Marascu, Alice, editor, Pinelli, Fabio, editor, Berlingerio, Michele, editor, and Hurley, Neil, editor

Published
2019
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166. Supplementary Data from Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy

Author

Mu, Ming, primary, Huang, Chun-Xiang, primary, Qu, Chuang, primary, Li, Pei-Lin, primary, Wu, Xiang-Ning, primary, Yao, Wudexin, primary, Shen, Chu, primary, Huang, Rucheng, primary, Wan, Chao-Chao, primary, Jian, Zhi-Wei, primary, Zheng, Limin, primary, Wu, Rui-Qi, primary, Lao, Xiang-Ming, primary, and Kuang, Dong-Ming, primary

Published
2024
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173. Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy

Author

Mu, Ming, primary, Huang, Chun-Xiang, additional, Qu, Chuang, additional, Li, Pei-Lin, additional, Wu, Xiang-Ning, additional, Yao, Wudexin, additional, Shen, Chu, additional, Huang, Rucheng, additional, Wan, Chao-Chao, additional, Jian, Zhi-Wei, additional, Zheng, Limin, additional, Wu, Rui-Qi, additional, Lao, Xiang-Ming, additional, and Kuang, Dong-Ming, additional

Published
2024
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177. The effect of coronary calcification on diagnostic performance of machine learning–based CT-FFR: a Chinese multicenter study

Author

Di Jiang, Meng, Zhang, Xiao Lei, Liu, Hui, Tang, Chun Xiang, Li, Jian Hua, Wang, Yi Ning, Xu, Peng Peng, Zhou, Chang Sheng, Zhou, Fan, Lu, Meng Jie, Zhang, Jia Yin, Yu, Meng Meng, Hou, Yang, Zheng, Min Wen, Zhang, Bo, Zhang, Dai Min, Yi, Yan, Xu, Lei, Hu, Xiu Hua, Yang, Jian, Lu, Guang Ming, Ni, Qian Qian, and Zhang, Long Jiang

Published
2021
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181. Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

Author

Wang, Wei, Nguyen, Linh TT, Burlak, Christopher, Chegini, Fariba, Guo, Feng, Chataway, Tim, Ju, Shulin, Fisher, Oriana S, Miller, David W, Datta, Debajyoti, Wu, Fang, Wu, Chun-Xiang, Landeru, Anuradha, Wells, James A, Cookson, Mark R, Boxer, Matthew B, Thomas, Craig J, Gai, Wei Ping, Ringe, Dagmar, Petsko, Gregory A, and Hoang, Quyen Q

Subjects
Aging, Neurodegenerative, Brain Disorders, Parkinson's Disease, Acquired Cognitive Impairment, Dementia, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Neurological, Alum Compounds, Caspase 1, Cell Line, Tumor, Cell Survival, Dipeptides, Gene Expression Regulation, Humans, Inflammasomes, Interleukin-1beta, Lewy Bodies, Lipopolysaccharides, Neurons, Nigericin, Protein Aggregates, RNA, Small Interfering, Signal Transduction, Vitamin K 3, alpha-Synuclein, para-Aminobenzoates, synuclein, Parkinson's disease, caspase, inflammasome, aggregation
Abstract

The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare familial PD-associated mutations in aSyn render it aggregation-prone; however, PD patients carrying wild type (WT) aSyn also have aggregated aSyn in Lewy bodies. The mechanisms by which WT aSyn aggregates are unclear. Here, we report that inflammation can play a role in causing the aggregation of WT aSyn. We show that activation of the inflammasome with known stimuli results in the aggregation of aSyn in a neuronal cell model of PD. The insoluble aggregates are enriched with truncated aSyn as found in Lewy bodies of the PD brain. Inhibition of the inflammasome enzyme caspase-1 by chemical inhibition or genetic knockdown with shRNA abated aSyn truncation. In vitro characterization confirmed that caspase-1 directly cleaves aSyn, generating a highly aggregation-prone species. The truncation-induced aggregation of aSyn is toxic to neuronal culture, and inhibition of caspase-1 by shRNA or a specific chemical inhibitor improved the survival of a neuronal PD cell model. This study provides a molecular link for the role of inflammation in aSyn aggregation, and perhaps in the pathogenesis of sporadic PD as well.

Published
2016

186. PacBio Third-Generation Sequencing Reveals an ABO Gene Promoter Mutation, c.–35_–18del, Leading to Weakened B Antigen Expression.

Author

Lin-Nan Shao, Yue-Xin Xia, Yi-Cheng Yang, Ning Li, Chun-Xiang Li, and Shi-Hang Zhou

Subjects
ABO blood group system, GENE expression, TRANSCRIPTION factor Sp1, TRANSCRIPTION factors, JAPANESE people
Abstract

This article, published in the Annals of Laboratory Medicine, discusses the use of PacBio third-generation sequencing to identify a specific ABO gene promoter mutation, c.–35_–18del, which leads to weakened B antigen expression. The study describes two cases of patients with this mutation, both of whom displayed mixed-field weak B antigen expression. The mutation was found in the proximal promoter region and was cis-linked to the ABO*B.01 allele. This mutation has been observed in Asian populations and is associated with weakened B antigen expression. [Extracted from the article]

Published
2024
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188. Impact of machine learning–based coronary computed tomography angiography fractional flow reserve on treatment decisions and clinical outcomes in patients with suspected coronary artery disease

Author

Qiao, Hong Yan, Tang, Chun Xiang, Schoepf, U. Joseph, Tesche, Christian, Bayer, 2nd, Richard R., Giovagnoli, Dante A, Todd Hudson, Jr, H., Zhou, Chang Sheng, Yan, Jing, Lu, Meng Jie, Zhou, Fan, Lu, Guang Ming, Jiang, Jian Wei, and Zhang, Long Jiang

Published
2020
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191. The influence of image quality on diagnostic performance of a machine learning–based fractional flow reserve derived from coronary CT angiography

Author

Xu, Peng Peng, Li, Jian Hua, Zhou, Fan, Jiang, Meng Di, Zhou, Chang Sheng, Lu, Meng Jie, Tang, Chun Xiang, Zhang, Xiao Lei, Yang, Liu, Zhang, Yuan Xiu, Wang, Yi Ning, Zhang, Jia Yin, Yu, Meng Meng, Hou, Yang, Zheng, Min Wen, Zhang, Bo, Zhang, Dai Min, Yi, Yan, Xu, Lei, Hu, Xiu Hua, Liu, Hui, Lu, Guang Ming, Ni, Qian Qian, and Zhang, Long Jiang

Published
2020
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198. Vasculitis

Author

Han, Chun-Lei, Wang, Ying, Zhang, Chun-Xiang, Chen, Ren-Gui, Sun, Guo-Jun, Ao, Jun-Hong, Chang, Jian-Min, Xiong, Xia, Xu, Bin, Zhang, Ru-Zhi, Zhu, Wen-Yuan, editor, Tan, Cheng, editor, and Zhang, Ru-zhi, editor

Published
2018
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