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• The interval from the onset of symptoms to the diagnosis in 79 children with primary brain tumors was compared with that in 45 children with Wilms' tumor and 123 children with acute leukemia. The patients with brain tumors had a significant delay from symptom onset to diagnosis. Only 38% of primary brain tumors were diagnosed within the first month after the onset of symptoms. In contrast, 84% of Wilms' tumors and 80% of cases of acute leukemia were diagnosed within one month of the onset of symptoms. Early detection of brain tumors is important as it may have a significant bearing on clinical outcome.(AJDC 1986;140:684-686)

The article discusses emergency management situations handled by police in the U.S. It mentions the memory of Captain Michael Krumm of the Michigan State Police of assisting emergency situations in Union Beach, New Jersey, during the 2012 Sandy Hurricane, where the entire neighbourhoods were submerged. It also mentions of Ed Moore of the New Jersey State Police who recalls Pennsylvania manhunt for accused killer Eric Frein.

It was a time of broken spirits and maddening despair, an era when stockbrokers were reduced to selling apples on street corners, and proud farmers lost their homes to lenders [...]

The article presents nine social movement leaders from around the world who share their hopes for 2018. They include Alicia Garza, organizer and co-founder of Black Lives Matter, who hopes that Black people will unite in rejecting anti-Black racism, Annie Leonard, executive director of Greenpeace USA who hopes that concern for climate change will grow, and Palestinian American educator Samia Shoman who hopes an end to the oppression and violence against Palestinians by the Israeli government.

The article focuses on the development of a comprehensive strategy to educate newly appointed governors on natural disasters by the U.S. Federal Emergency Management Agency (FEMA) in 2011. It notes that extensive briefings on the process of declaring disasters are conducted by the National Governors Association (NGA) and FEMA. It also claims that the new governors will undergo state emergency management director training.

The article features Gustavo Castro Soto, said to be the sole eyewitness to the assassination of Honduran social movement leader Berta Cáceres on March 3, 2016. It notes that Castro can also be framed as murderer of Cáceres and due to this reason, the local authorities are preventing him from leaving Honduras and to return to his native Mexico. Dolores Jiménez, Mexico's ambassador to Honduras, is mentioned.

An obituary forBerta Isabel Cáceres Flores, fighter for indigenous people and cofounder of the Civic Council of Popular and Indigenous Organizations of Honduras (COPINH), is presented.

The article reports on the functions of Emergency Management Assistance Compact (EMAC). As its meaning suggests, EMAC provides assistance in a disaster. But the assistance only takes place once the governor of the affected state declares a state of emergency and the affected state asks for help. If a state does not ask assistance from EMAC, EMAC cannot send help.

This article reports on the response efforts in the aftermath of Hurricane Katrina and Hurricane Rita, and the U.S. Congress' initiative in improving the recovery's financing in 2005. The Emergency Management Assistance Compact has deployed personnel and equipment, which includes approximately 52,000 emergency response professionals and National Guardsmen, as well as resources amounting to $700 million in aid. The U.S. Congress has held numerous committee and subcommittee hearings to remedy the failures with the response to Hurricane Katrina. Representatives from victim relief organizations have testified, together with health officials, educators and infrastructure experts.

Highlights the Second Continental Summit of Indigenous Peoples and Nationalities of Abya Yala held in Quito, Ecuador in July 2004. Number of summit attendees from several Indigenous nations and countries; Information on the assaults and violations facing Indigenous communities and nations that are discussed in the summit; Themes of the summit; Concerns and demands of Indigenous peoples.

The article discusses the struggle of the Afro-Indigenous Garifuna people to protect their heritage with the aid of the National Fraternal Black Organization of Honduras or OFRANEH. It is noted that Honduras has one of the worst levels of homicide and human rights abuse cases which has also affected other indigenous peoples such as the Garifuna, Lenca and Maya Chortí. Coordinator Miriam Miranda and human rights organizer Carla Garcia cite efforts to defend their culture and language.

The article reports that April 1, 2014 marks one year since the members of the Indigenous Council of the Lenca community of Rio Blanco in Honduras began human barricade that has so far stopped DEAS Corp. from constructing a dam that would destroy their sacred Gualcarque River. It relates how the U.S. government has been a strong force behind the exaltation of natural riches in Honduras. It also informs that the U.S. government has accused the Lenca community of trying to block development.

The article looks at the effort by the indigenous people in Honduras to protect their ancestral lands in 2013. The author argues that national and international law should protect the people's ancestral lands. She criticizes the government and corporations for trying to break the resistance and obtain control over the lands, forests and waters. The indigenous movement is noted for lacking the global attention of similar movements.

In a retrospective study, we previously demonstrated that TELgene rearrangements, representing the TEL-AML1fusion created by the t(12;21), conferred a favorable prognosis among children with newly diagnosed acute lymphoblastic leukemia (ALL). In 1996, we undertook a prospective study of patients greater than one year of age with B-precursor ALL consecutively enrolled on the ALinC16 study to confirm this result in an independent cohort of patients with extended follow up, to determine the incidence of TELand MLLgene rearrangements, and to determine if TELgene status should be used for risk classification. Among 928 cases studied, TELgene rearrangements were detected in 244 (26%), including 29% of standard-risk and 21% of high-risk cases by the National Cancer Institute/Rome criteria. TEL-rearranged cases had a median age of 4.4 years (91% < 10 years) and a median presenting leukocyte count of 12 × 109/L (81% < 50 × 109/L). Cases with germline TELhad similar features, with a median age of 5.0 years and a median presenting leukocyte count of 12 × 109/L. At a median follow-up of 7.8 years, the 5-year event-free survival (EFS) ± SE for patients with TELrearrangements was 86% ± 2%, compared to 72% ± 2% for those with germline TEL(p<0.0001). TELrearrangements were associated with a favorable outcome among standard risk patients (5-yr EFS 88% ± 3% vs. 78% ± 2%, p=0.001) as well as high risk patients (5-yr EFS 81% ± 5% vs. 62% ± 3%, p=0.003). TELrearrangements were associated with a favorable outcome among patients with rapid early responses to therapy (5-yr EFS 87% ± 2% vs. 75% ± 2%, p=0.0002), but the association did not attain statistical significance among those with slow early responses (5-yr EFS 71% ± 12% vs. 56% ± 6%, p=0.16). Overall, patients with TELrearrangements had an outcome similar to that of patients with trisomies 4 and 10 (5-yr EFS 86% ± 2% vs. 82% ± 3%, p=0.18). By contrast, MLLrearrangements were detected in only 19 cases (2%) and the 5-yr EFS for patients with this genetic abnormality was 58% ± 11%, compared to 76% ± 1% for those with germline MLL(p=0.02). MLLrearrangements were associated with a significantly worse outcome among standard-risk patients (5-yr EFS 55% ± 2% vs. 82% ± 2%, p=0.01), but not among high-risk patients (5-yr EFS 63% ± 2% vs. 66% ± 3%, p=0.57). However, these findings should be interpreted with caution because of the small number of patients with MLLrearrangements in each risk group. The finding of TELrearrangements in association with a favorable prognosis among both standard-risk and high-risk patients indicates that TELgene status should be incorporated into current risk classification schemes for childhood ALL. We suggest that patients with TELrearrangements and good early responses to therapy should be assigned to lower-risk treatment protocols.

The article discusses a court case wherein the new bid of Kimberley Thompson of Hey Head Farm for a licence was revoked again by the North Western England Traffic Commissioner (TC) Beverley Bell. Her previous licence was revoked for failing to respond to requests from the Traffic Area Office. The application of her partner Paul Harrison for a new restricted licence was granted on the basis that the vehicles would be used only for agricultural purposes. The TC cited her dissatisfaction about the position of Thompson with various finance houses.

Several letters to the editor are presented in response to articles in previous issues including "Who Will Guard the Guardians?," in the July 13, 2006 issue, the closure of the Truckworld parking facility for truck drivers in England and the evaluation of the Dutch Hover-Track rear-wheel track system.

Reports that Morgan Brothers has been allowed to operate just one vehicle after a disciplinary inquiry to explain unsatisfactory maintenance investigations in Wales. Initial failure rate at the annual test of its vehicles; Frequency of vehicle inspection according to company owner Richard Morgan.

Reports on the accusation against container operator Gipping Container Services for falsifying tachograph records. Number of license being held by the firm on its vehicles; Results of an examination of the tachograph records of the company conducted by traffic examiner Sarah Bell; Remarks from company transport manager Hussein Ahmed on their business.

Discusses the misjudgment on the ruling of North Western Traffic Commissioner (TC) Beverley Bell over the case of the validity of the five-vehicle license held by Farnworth, Bolton, England-based Al Madina Transport. Disregard for system improvements by the TC; Refusal of Bell to adjourn the hearing despite the reasonable cause of the absence of Al Madina director Nazir Hussain during the inquiry process; Decision of the Transport Tribunal on the appeal of the company.

Reports on the return of an impounded commercial vehicle to the Bank of Scotland by North Western Traffic Commissioner Beverley Bell, following the assurance of the company that it will not be returned to Quick Contractors who had been operating the vehicle without an O-license in 2004. Background on the case; Views of Bell on the proactive approach of the Vehicle and Operator Services Agency to impounding.