Search

Your search keyword '"de Groot, Lisette C. P. G. M."' showing total 741 results
Start Over Author "de Groot, Lisette C. P. G. M."
741 results on '"de Groot, Lisette C. P. G. M."'

101. Corrigendum: A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis [Human Molecular Genetics., 26, 13, (2017) (2577-2588)] DOI: 10.1093/hmg/ddx151

Author

Munz, Matthias, Willenborg, Christina, Richter, Gesa M., Jockel-Schneider, Yvonne, Graetz, Christian, Staufenbiel, Ingmar, Wellmann, J. rgen, Berger, Klaus, Krone, Bastian, Hoffmann, Per, van der Velde, Nathalie, Uitterlinden, André G., de Groot, Lisette C. P. G. M., Sawalha, Amr H., Direskeneli, Haner, Saruhan-Direskeneli, G. her, Guzeldemir-Akcakanat, Esra, Keceli, Huseyin Gencay, Laudes, Matthias, Noack, Barbara, Teumer, Alexander, Holtfreter, Birte, Kocher, Thomas, Eickholz, Peter, Meyle, J. rg, Doerfer, Christof, Bruckmann, Corinna, Lieb, Wolfgang, Franke, Andre, Schreiber, Stefan, Nohutcu, Rahime M., Erdmann, Jeanette, Loos, Bruno G., Jepsen, Soeren, Dommisch, Henrik, and Schaefer, Arne S.

Abstract

The authors wish to apologize for the following two errors in the original article: (i) the first name of a co-author, Huseyin Gencay Keceli, was omitted; (ii) the statement 'This research was financially supported by the Turkish Scientific and Research Council (TUBITAK) (Grant no: 114S543)' was omitted. These have both now been corrected online.

Published
2018

102. Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults

Author

Montiel Rojas, Diego, Nilsson, Andreas, Ponsot, Elodie, Brummer, Robert J., Fairweather-Tait, Susan, Jennings, Amy, de Groot, Lisette C. P. G. M., Berendsen, Agnes, Pietruszka, Barbara, Madej, Dawid, Caumon, Elodie, Meunier, Nathalie, Malpuech Brugère, Corinne, Guidarelli, Giulia, Santoro, Aurelia, Franceschi, Claudio, and Kadi, Fawzi

Subjects
aging, ethnicity, handgrip strength, SF-36, physical function, physiology, Physiologie
Published
2018

103. Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?

Author

Oliai Araghi, Sadaf, primary, Kiefte-de Jong, Jessica C., additional, Trajanoska, Katerina, additional, Koromani, Fjorda, additional, Rivadeneira, Fernando, additional, Zillikens, M. Carola, additional, van Schoor, Natasja M., additional, de Groot, Lisette C. P. G. M., additional, Ikram, M. Arfan, additional, Uitterlinden, André G., additional, Stricker, Bruno H., additional, and van der Velde, Nathalie, additional

Published
2019
Full Text
View/download PDF

105. Leucine coingestion augments the muscle protein synthetic response to the ingestion of 15 g of protein following resistance exercise in older men

Author

Holwerda, Andrew M., primary, Paulussen, Kevin J. M., additional, Overkamp, Maarten, additional, Goessens, Joy P. B., additional, Kramer, Irene-Fleur, additional, Wodzig, Will K. W. H., additional, Verdijk, Lex B., additional, de Groot, Lisette C. P. G. M., additional, and van Loon, Luc J. C., additional

Published
2019
Full Text
View/download PDF

108. B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study

Author

Oliai Araghi, Sadaf, primary, Braun, Kim V. E., additional, van der Velde, Nathalie, additional, van Dijk, Suzanne C., additional, van Schoor, Natasja M., additional, Zillikens, M. Carola, additional, de Groot, Lisette C. P. G. M., additional, Uitterlinden, Andre G., additional, Stricker, Bruno H., additional, Voortman, Trudy, additional, and Kiefte-de Jong, Jessica C., additional

Published
2019
Full Text
View/download PDF

109. A Novel Approach to Improve the Estimation of a Diet Adherence Considering Seasonality and Short Term Variability – The NU-AGE Mediterranean Diet Experience

Author

Giampieri, Enrico, primary, Ostan, Rita, additional, Guidarelli, Giulia, additional, Salvioli, Stefano, additional, Berendsen, Agnes A. M., additional, Brzozowska, Anna, additional, Pietruszka, Barbara, additional, Jennings, Amy, additional, Meunier, Nathalie, additional, Caumon, Elodie, additional, Fairweather-Tait, Susan, additional, Sicinska, Ewa, additional, Feskens, Edith J. M., additional, de Groot, Lisette C. P. G. M., additional, Franceschi, Claudio, additional, and Santoro, Aurelia, additional

Published
2019
Full Text
View/download PDF

110. Disentangling the genetics of lean mass

Author

Karasik, David, primary, Zillikens, M Carola, additional, Hsu, Yi-Hsiang, additional, Aghdassi, Ali, additional, Akesson, Kristina, additional, Amin, Najaf, additional, Barroso, Inês, additional, Bennett, David A, additional, Bertram, Lars, additional, Bochud, Murielle, additional, Borecki, Ingrid B, additional, Broer, Linda, additional, Buchman, Aron S, additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos-Obando, Natalia, additional, Cauley, Jane A, additional, Cawthon, Peggy M, additional, Chambers, John C, additional, Chen, Zhao, additional, Cho, Nam H, additional, Choi, Hyung Jin, additional, Chou, Wen-Chi, additional, Cummings, Steven R, additional, de Groot, Lisette C P G M, additional, De Jager, Phillip L, additional, Demuth, Ilja, additional, Diatchenko, Luda, additional, Econs, Michael J, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W, additional, Eriksson, Joel, additional, Eriksson, Johan G, additional, Estrada, Karol, additional, Evans, Daniel S, additional, Feitosa, Mary F, additional, Fu, Mao, additional, Gieger, Christian, additional, Grallert, Harald, additional, Gudnason, Vilmundur, additional, Lenore, Launer J, additional, Hayward, Caroline, additional, Hofman, Albert, additional, Homuth, Georg, additional, Huffman, Kim M, additional, Husted, Lise B, additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Johnson, Toby, additional, Biffar, Reiner, additional, Jordan, Joanne M, additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O, additional, Klopp, Norman, additional, Kloth, Jacqueline S L, additional, Koller, Daniel L, additional, Kooner, Jaspal S, additional, Kraus, William E, additional, Kritchevsky, Stephen, additional, Kutalik, Zoltán, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L, additional, Lerch, Markus M, additional, Lewis, Joshua R, additional, Lill, Christina, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Livshits, Gregory, additional, Ljunggren, Östen, additional, Loos, Ruth J F, additional, Lorentzon, Mattias, additional, Luan, Jian'an, additional, Luben, Robert N, additional, Malkin, Ida, additional, McGuigan, Fiona E, additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D, additional, Morris, Andrew P, additional, Mosekilde, Leif, additional, Nethander, Maria, additional, Newman, Anne B, additional, O'Connell, Jeffery R, additional, Oostra, Ben A, additional, Orwoll, Eric S, additional, Palotie, Aarno, additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Prince, Richard L, additional, Psaty, Bruce M, additional, Räikkönen, Katri, additional, Ralston, Stuart H, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Robbins, John A, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schipf, Sabine, additional, Shin, Chan Soo, additional, Smith, Albert V, additional, Smith, Shad B, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Stančáková, Alena, additional, Stefansson, Kari, additional, Steinhagen-Thiessen, Elisabeth, additional, Stolk, Lisette, additional, Streeten, Elizabeth A, additional, Styrkarsdottir, Unnur, additional, Swart, Karin M A, additional, Thompson, Patricia, additional, Thomson, Cynthia A, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, van Schoor, Natasja M, additional, Vandenput, Liesbeth, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, J Wareham, Nicholas, additional, Waterworth, Dawn, additional, Weedon, Michael N, additional, Wichmann, H-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M K, additional, Wilson, James F, additional, Wright, Nicole C, additional, Yerges-Armstrong, Laura M, additional, Yu, Lei, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhou, Yanhua, additional, Nielson, Carrie M, additional, Harris, Tamara B, additional, Demissie, Serkalem, additional, Kiel, Douglas P, additional, and Ohlsson, Claes, additional

Published
2019
Full Text
View/download PDF

111. Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse

Author

Horstman, Astrid M. H., primary, Backx, Evelien M. P., additional, Smeets, Joey S. J., additional, Marzuca-Nassr, Gabriel N., additional, van Kranenburg, Janneau, additional, de Boer, Douwe, additional, Dolmans, John, additional, Snijders, Tim, additional, Verdijk, Lex B., additional, de Groot, Lisette C. P. G. M., additional, and van Loon, Luc J. C., additional

Published
2019
Full Text
View/download PDF

112. A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

Author

Santoro, Aurelia, primary, Bazzocchi, Alberto, additional, Guidarelli, Giulia, additional, Ostan, Rita, additional, Giampieri, Enrico, additional, Mercatelli, Daniele, additional, Scurti, Maria, additional, Berendsen, Agnes, additional, Surala, Olga, additional, Jennings, Amy, additional, Meunier, Nathalie, additional, Caumon, Elodie, additional, Gillings, Rachel, additional, Kadi, Fawzi, additional, Capel, Frederic, additional, Cashman, Kevin D., additional, Pietruszka, Barbara, additional, Feskens, Edith J. M., additional, De Groot, Lisette C. P. G. M., additional, Battista, Giuseppe, additional, Salvioli, Stefano, additional, and Franceschi, Claudio, additional

Published
2018
Full Text
View/download PDF

113. Positive effects of folic acid supplementation on cognitive aging are dependent on ω-3 fatty acid status: a post hoc analysis of the FACIT trial.

Author

van Soest, Annick P M, van de Rest, Ondine, Witkamp, Renger F, and de Groot, Lisette C P G M

Subjects
THERAPEUTIC use of folic acid, STATISTICS, ACTIVE aging, COGNITIVE aging, TREATMENT effectiveness, OMEGA-3 fatty acids, DESCRIPTIVE statistics, FOLIC acid, DATA analysis
Abstract

Background Although epidemiological studies suggest a protective role of B vitamins and omega-3 (ω-3) fatty acids in cognitive decline, findings from intervention studies are conflicting. Mechanistic studies suggest that the ω-3 (n–3) fatty acid status can modulate the effects of B vitamins on cognitive decline. Objectives We investigated the interaction between baseline ω-3 fatty acid statuses and folic acid treatment on cognitive decline in a placebo-controlled trial [FACIT (Folic Acid and Carotid Intima-media Thickness)]. Methods This post hoc analysis included 791 older adults aged 50–70 y with plasma total homocysteine ≥13 µmol/L and ≤26 µmol/L and serum vitamin B12 ≥200 pmol/L. Participants received 800 µg folic acid or placebo daily for 3 y. Global cognitive functioning and domain-specific functioning (episodic memory, information processing speed, executive functioning) were assessed at baseline and after 3 y. The effect of the folic acid supplementation was analyzed according to tertiles of baseline ω-3 fatty acid concentrations using linear multiple regression. Results The mean ± SD age of the study population was 60.2 ± 5.6 y, and the mean ± SD Mini-Mental State Examination score was 28.6 ± 1.5. The treatment effect of folic acid was significantly larger in participants in the low compared to high ω-3 fatty acid tertile for global cognition (difference in z-score: mean ± SE = 0.16 ± 0.059; P  < 0.01). Regarding domain-specific functioning, similar results were observed for information processing speed (mean ± SE = 0.167 ± 0.068; P  = 0.01). There were no overall interactions between folic acid treatment and ω-3 fatty acid tertiles for episodic memory (P  = 0.14) and executive functioning (P  = 0.21). Conclusions This post hoc analysis revealed that the efficacy of folic acid treatment on cognitive functioning is dependent on the ω-3 fatty acid status. Individuals with a lower ω-3 fatty acid status at baseline benefited from folic acid treatment, while individuals with a higher ω-3 fatty acid status did not. The results potentially explain the inconsistency in outcomes of B-vitamin supplementation trials and emphasize the importance of a personalized approach. This trial was registered at clinicaltrials.gov as NCT00110604. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

114. Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study.

Author

Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A M, Deen, Carolien P J, Kema, Ido P, Bakker, Stephan J L, Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J M, and de Groot, Lisette C P G M

Subjects
NIACIN, HOMOCYSTEINE, EXERCISE tests, GRIP strength, ACTIVE aging, VITAMIN B6, VITAMIN B12, MUSCLE contraction, INGESTION, REGRESSION analysis, PHYSICAL activity, DIETARY supplements, BODY movement, QUESTIONNAIRES, DESCRIPTIVE statistics, FOLIC acid, DATA analysis software, OLD age
Abstract

Background Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. Objectives The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. Methods We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n  = 1249 healthy older adults (aged 65–79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. Results Intake of vitamin B-6 was related to lower chair rise test time [β: –0.033 ± 0.016 s (log); P  = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P  = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: –1.4 ± 0.7 kg; P  = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. Conclusions Vitamin B-6 intake was associated with better chair rise test time in a population of European healthy older adults and also with greater handgrip strength in participants with low physical activity only. Homocysteine concentrations did not mediate these associations. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

115. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Author

Jiang, Xia, O'Reilly, Paul F., Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J. Brent, Dupuis, Josee, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A., Albanes, Demetrius, Lutsey, Pamela L., Yao, Lu, Tang, Weihong, Econs, Michael J., Wallaschofski, Henri, Voelzke, Henry, Zhou, Ang, Power, Chris, McCarthy, Mark I., Michos, Erin D., Boerwinkle, Eric, Weinstein, Stephanie J., Freedman, Neal D., Huang, Wen-Yi, Van Schoor, Natasja M., van der Velde, Nathalie, de Groot, Lisette C. P. G. M., Enneman, Anke, Cupples, L. Adrienne, Booth, Sarah L., Vasan, Ramachandran S., Liu, Ching-Ti, Zhou, Yanhua, Ripatti, Samuli, Ohlsson, Claes, Vandenput, Liesbeth, Lorentzon, Mattias, Eriksson, Johan G., Shea, M. Kyla, Houston, Denise K., Kritchevsky, Stephen B., Liu, Yongmei, Lohman, Kurt K., Ferrucci, Luigi, Peacock, Munro, Gieger, Christian, Beekman, Marian, Slagboom, Eline, Deelen, Joris, van Heemst, Diana, Kleber, Marcus E., Maerz, Winfried, de Boer, Ian H., Wood, Alexis C., Rotter, Jerome I., Rich, Stephen S., Robinson-Cohen, Cassianne, den Heijer, Martin, Jarvelin, Marjo-Riitta, Cavadino, Alana, Joshi, Peter K., Wilson, James F., Hayward, Caroline, Lind, Lars, Michaëlsson, Karl, Trompet, Stella, Zillikens, M. Carola, Uitterlinden, Andre G., Rivadeneira, Fernando, Broer, Linda, Zgaga, Lina, Campbell, Harry, Theodoratou, Evropi, Farrington, Susan M., Timofeeva, Maria, Dunlop, Malcolm G., Valdes, Ana M., Tikkanen, Emmi, Lehtimaki, Terho, Lyytikainen, Leo-Pekka, Kahonen, Mika, Raitakari, Olli T., Mikkila, Vera, Ikram, M. Arfan, Sattar, Naveed, Jukema, J. Wouter, Wareham, Nicholas J., Langenberg, Claudia, Forouhi, Nita G., Gundersen, Thomas E., Khaw, Kay-Tee, Butterworth, Adam S., Danesh, John, Spector, Timothy, Wang, Thomas J., Hypponen, Elina, Kraft, Peter, Kiel, Douglas P., Jiang, Xia, O'Reilly, Paul F., Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J. Brent, Dupuis, Josee, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A., Albanes, Demetrius, Lutsey, Pamela L., Yao, Lu, Tang, Weihong, Econs, Michael J., Wallaschofski, Henri, Voelzke, Henry, Zhou, Ang, Power, Chris, McCarthy, Mark I., Michos, Erin D., Boerwinkle, Eric, Weinstein, Stephanie J., Freedman, Neal D., Huang, Wen-Yi, Van Schoor, Natasja M., van der Velde, Nathalie, de Groot, Lisette C. P. G. M., Enneman, Anke, Cupples, L. Adrienne, Booth, Sarah L., Vasan, Ramachandran S., Liu, Ching-Ti, Zhou, Yanhua, Ripatti, Samuli, Ohlsson, Claes, Vandenput, Liesbeth, Lorentzon, Mattias, Eriksson, Johan G., Shea, M. Kyla, Houston, Denise K., Kritchevsky, Stephen B., Liu, Yongmei, Lohman, Kurt K., Ferrucci, Luigi, Peacock, Munro, Gieger, Christian, Beekman, Marian, Slagboom, Eline, Deelen, Joris, van Heemst, Diana, Kleber, Marcus E., Maerz, Winfried, de Boer, Ian H., Wood, Alexis C., Rotter, Jerome I., Rich, Stephen S., Robinson-Cohen, Cassianne, den Heijer, Martin, Jarvelin, Marjo-Riitta, Cavadino, Alana, Joshi, Peter K., Wilson, James F., Hayward, Caroline, Lind, Lars, Michaëlsson, Karl, Trompet, Stella, Zillikens, M. Carola, Uitterlinden, Andre G., Rivadeneira, Fernando, Broer, Linda, Zgaga, Lina, Campbell, Harry, Theodoratou, Evropi, Farrington, Susan M., Timofeeva, Maria, Dunlop, Malcolm G., Valdes, Ana M., Tikkanen, Emmi, Lehtimaki, Terho, Lyytikainen, Leo-Pekka, Kahonen, Mika, Raitakari, Olli T., Mikkila, Vera, Ikram, M. Arfan, Sattar, Naveed, Jukema, J. Wouter, Wareham, Nicholas J., Langenberg, Claudia, Forouhi, Nita G., Gundersen, Thomas E., Khaw, Kay-Tee, Butterworth, Adam S., Danesh, John, Spector, Timothy, Wang, Thomas J., Hypponen, Elina, Kraft, Peter, and Kiel, Douglas P.

Abstract

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10−9 at rs8018720 in SEC23A, and P = 1.9×10−14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene–gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.

Published
2018
Full Text
View/download PDF

116. Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries

Author

Jeruszka-Bielak, Marta, Kollajtis-Dolowy, Anna, Santoro, Aurelia, Ostan, Rita, Berendsen, Agnes A. M., Jennings, Amy, Meunier, Nathalie, Marseglia, Anna, Caumon, Elodie, Gillings, Rachel, de Groot, Lisette C. P. G. M., Franceschi, Claudio, Hieke, Sophie, Pietruszka, Barbara, Jeruszka-Bielak, Marta, Kollajtis-Dolowy, Anna, Santoro, Aurelia, Ostan, Rita, Berendsen, Agnes A. M., Jennings, Amy, Meunier, Nathalie, Marseglia, Anna, Caumon, Elodie, Gillings, Rachel, de Groot, Lisette C. P. G. M., Franceschi, Claudio, Hieke, Sophie, and Pietruszka, Barbara

Abstract

Background: Nutrition-related knowledge (NRK) and nutrition-related attitudes (NRAs) are necessary for dietary changes toward healthier dietary patterns. In turn, healthier dietary patterns can be beneficial in maintaining health of older adults. Therefore, the aim of this cross-sectional study was to investigate whether NRK and NRAs were associated with lifestyle and health features among older adults (65+ years) from five European countries (France, Italy, Poland, the Netherlands and United Kingdom). Methods: Within the European project NU-AGE, 1,144 healthy elderly volunteers (65-79 years) were randomly assigned to two groups: intervention (NU-AGE diet) or control. After 1-year of follow-up, both NRK and NRAs were assessed during exit interviews, in combination with a number of lifestyle and health variables (e.g., physical activity, smoking, alcohol use, BMI, self-assessed health status). Multivariable linear regression models were used in data analysis. Results: In the NU-AGE study sample, good NRK was associated with lower BMI and higher physical activity. More positive NRAs were related to lower BMI and self-reported very good or good appetite. Moreover, both NRK and NRAs were associated with some socio-economic determinants, like financial situation, age, education, living area (for NRK), and country (for NRAs). Participants in the intervention group showed a better NRK (beta = 0 367 [95% CI 0.117; 0.617], p = 0.004) and more positive NRAs beta = 0.838 [95% CI 0.318, 1.358], p = 0.002) than those in the control group. Higher self-evaluated knowledge was also significantly related to more positive NRAs (p < 0.001). The most popular sources of nutrition information were food labels, books and magazines on health, the dietitian and the doctor's office, although their importance varied significantly among countries, and, to a lesser extent, between women and men and between intervention and control group. Conclusion: Higher NRK and NRA scores were associated

Published
2018
Full Text
View/download PDF

117. Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial

Author

Marseglia, Anna, Xu, Weili, Fratiglioni, Laura, Fabbri, Cristina, Berendsen, Agnes A. M., Bialecka-Debek, Agata, Jennings, Amy, Gillings, Rachel, Meunier, Nathalie, Caumon, Elodie, Fairweather-Tait, Susan, Pietruszka, Barbara, De Groot, Lisette C. P. G. M., Santoro, Aurelia, Franceschi, Claudio, Marseglia, Anna, Xu, Weili, Fratiglioni, Laura, Fabbri, Cristina, Berendsen, Agnes A. M., Bialecka-Debek, Agata, Jennings, Amy, Gillings, Rachel, Meunier, Nathalie, Caumon, Elodie, Fairweather-Tait, Susan, Pietruszka, Barbara, De Groot, Lisette C. P. G. M., Santoro, Aurelia, and Franceschi, Claudio

Abstract

Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE's dietary intervention on age related cognitive decline. Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65-79 years, from five European centers. Participants were randomly allocated into two groups: control (n = 638), following a habitual diet; and, intervention (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD total score), and five cognitive domains (perceptual speed, executive function, episodic memory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed effects models. Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from the intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but diff

Published
2018
Full Text
View/download PDF

118. A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study : Sex and Country Specific Features

Author

Santoro, Aurelia, Bazzocchi, Alberto, Guidarelli, Giulia, Ostan, Rita, Giampieri, Enrico, Mercatelli, Daniele, Scurti, Maria, Berendsen, Agnes, Surala, Olga, Jennings, Amy, Meunier, Nathalie, Caumon, Elodie, Gillings, Rachel, Kadi, Fawzi, Capel, Frederic, Cashman, Kevin D., Pietruszka, Barbara, Feskens, Edith J. M., De Groot, Lisette C. P. G. M., Battista, Giuseppe, Salvioli, Stefano, Franceschi, Claudio, Santoro, Aurelia, Bazzocchi, Alberto, Guidarelli, Giulia, Ostan, Rita, Giampieri, Enrico, Mercatelli, Daniele, Scurti, Maria, Berendsen, Agnes, Surala, Olga, Jennings, Amy, Meunier, Nathalie, Caumon, Elodie, Gillings, Rachel, Kadi, Fawzi, Capel, Frederic, Cashman, Kevin D., Pietruszka, Barbara, Feskens, Edith J. M., De Groot, Lisette C. P. G. M., Battista, Giuseppe, Salvioli, Stefano, and Franceschi, Claudio

Abstract

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65-79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles

Published
2018
Full Text
View/download PDF

119. Beta-blocker use and fall risk in older individuals:Original results from two studies with meta-analysis

Author

Ham, Annelies C., van Dijk, Suzanne C., Swart, Karin M. A., Enneman, Anke W., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van Schoor, Natasja M., Carola Zillikens, M., Lips, Paul, de Groot, Lisette C. P. G. M., Hofman, Albert, Witkamp, Renger F., Uitterlinden, André G., Stricker, Bruno H., van der Velde, Nathalie, Epidemiology, Internal Medicine, Surgery, General practice, APH - Aging & Later Life, Epidemiology and Data Science, Internal medicine, Geriatrics, and AMS - Amsterdam Movement Sciences

Subjects
Global Nutrition, Wereldvoeding, Meta-analysis, CYP2D6, β-blockers, Falls, Nutritional Biology, VLAG
Abstract

Aims: To investigate the association between use of β-blockers and β-blocker characteristics – selectivity, lipid solubility, intrinsic sympathetic activity (ISA) and CYP2D6 enzyme metabolism – and fall risk. Methods: Data from two prospective studies were used, including community-dwelling individuals, n = 7662 (the Rotterdam Study) and 2407 (B-PROOF), all aged ≥55 years. Fall incidents were recorded prospectively. Time-varying β-blocker use was determined using pharmacy dispensing records. Cox proportional hazard models adjusted for age and sex were applied to determine the association between β-blocker use, their characteristics – selectivity, lipid solubility, ISA and CYP2D6 enzyme metabolism – and fall risk. The results of the studies were combined using meta-analyses. Results: In total 2917 participants encountered a fall during a total follow-up time of 89 529 years. Meta-analysis indicated no association between use of any β-blocker, compared to nonuse, and fall risk, hazard ratio (HR) = 0.97 [95% confidence interval (CI) 0.88–1.06]. Use of a selective β-blocker was also not associated with fall risk, HR = 0.92 (95%CI 0.83–1.01). Use of a nonselective β-blocker was associated with an increased fall risk, HR = 1.22 (95%CI 1.01–1.48). Other β-blocker characteristics including lipid solubility and CYP2D6 enzyme metabolism were not associated with fall risk. Conclusion: Our study suggests that use of a nonselective β-blocker, contrary to selective β-blockers, is associated with an increased fall risk in an older population. In clinical practice, β-blockers have been shown effective for a variety of cardiovascular indications. However, fall risk should be considered when prescribing a β-blocker in this age group, and the pros and cons for β-blocker classes should be taken into consideration.

Published
2017

120. Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

Author

Shankar Ghosh, Tarini, Rampelli, Simone, Jeffery, Ian B., Santoro, Aurelia, Neto, Marta, Capri, Miriam, Giampieri, Enrico, Jennings, Amy, Candela, Marco, Turroni, Silvia, Zoetendal, Erwin G., Hermes, Gerben D. A., Elodie, Caumon, Meunier, Nathalie, Malpuech Brugere, Corinne, Guillot, Estelle Pujos, Berendsen, Agnes M., De Groot, Lisette C. P. G. M., Feskins, Edith J. M., and Kaluza, Joanna

Subjects
MEDITERRANEAN diet, OLDER people, GUT microbiome, FRAIL elderly, SMALL intestinal bacterial overgrowth, LEPTIN, MICROBIAL proteins
Published
2020
Full Text
View/download PDF

121. The association between dietary and skin advanced glycation end products: the Rotterdam Study.

Author

Chen, Jinluan, Waqas, Komal, Tan, Robby Carlo, Voortman, Trudy, Ikram, M Arfan, Nijsten, Tamar E C, de Groot, Lisette C P G M, Uitterlinden, André G, and Zillikens, M Carola

Subjects
DIABETES complications, CHRONIC kidney failure complications, CONFIDENCE intervals, DIET, REGRESSION analysis, SKIN physiology, SKIN aging, TRANSFERASES, DESCRIPTIVE statistics, QUESTIONNAIRES, DIETARY advanced glycation end-products, DIETARY proteins
Abstract

Background Advanced glycation end products (AGEs) accumulate in tissues with age and in conditions such as diabetes mellitus and chronic kidney disease (CKD), and they may be involved in age-related diseases. Skin AGEs measured as skin autofluorescence (SAF) are a noninvasive reflection of long-term AGE accumulation in tissues. Whether AGEs present in the diet (dAGEs) contribute to tissue AGEs is unclear. Objectives Our aim was to investigate the association between dietary and skin AGEs in the Rotterdam Study, a population-based cohort of mainly European ancestry. Methods In 2515 participants, intake of 3 dAGEs [carboxymethyl-lysine (CML), N -(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MGH1), and carboxyethyl-lysine (CEL)] was estimated using FFQs and the content of AGEs measured in commonly consumed foods. SAF was measured 5 y (median value) later using an AGE Reader. The association of dAGEs with SAF was analyzed in linear regression models and stratified for diabetes and chronic kidney disease (CKD, defined as estimated glomerular filtration rate ≤60 mL/min) status. Results Mean ± SD intake was 3.40 ±0.89 mg/d for CML, 28.98 ±7.87 mg/d for MGH1, and 3.11 ±0.89 mg/d for CEL. None of them was associated with SAF in the total study population. However, in stratified analyses, CML was positively associated with SAF after excluding both individuals with diabetes and individuals with CKD: 1 SD higher daily CML intake was associated with a 0.03 (95% CI: 0.009, 0.05) arbitrary units higher SAF. MGH1 and CEL intake were not significantly associated with SAF. Nevertheless, the associations were stronger when the time difference between dAGEs and SAF measurements was shorter. Conclusions Higher dietary CML intake was associated with higher SAF only among participants with neither diabetes nor CKD, which may be explained by high AGE formation in diabetes and decreased excretion in CKD or by dietary modifications in these disease groups. The dAGE–SAF associations were also modified by the time difference between measurements. Our results suggest that dAGEs can influence tissue AGE accumulation and possibly thereby age-related diseases. This trial was registered at the Netherlands National Trial Register as NTR6831 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6831) and at the WHO International Clinical Trials Registry Platform as NTR6831 (http://www.who.int/ictrp/network/primary/en/). [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

122. Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?

Author

Oliai Araghi, Sadaf, Kiefte-de Jong, Jessica C., Trajanoska, Katerina, Koromani, Fjorda, Rivadeneira, Fernando, Zillikens, M. Carola, van Schoor, Natasja M., de Groot, Lisette C. P. G. M., Ikram, M. Arfan, Uitterlinden, André G., Stricker, Bruno H., and van der Velde, Nathalie

Subjects
CALCIUM supplements, VITAMIN D, BONE density, CALCIUM, CANCELLOUS bone, DIURETICS, CHOLECALCIFEROL, BONE physiology, FOOD habits, BONES, PHOTON absorptiometry, DRUG-food interactions, INGESTION, SURVEYS, QUESTIONNAIRES, MEMBRANE proteins, DIETARY calcium, LUMBAR vertebrae, LONGITUDINAL method
Abstract

Loop diuretics (LD) may affect bone health by inhibiting renal calcium reuptake. However, whether vitamin D status and dietary calcium intake modify the association between LD and bone outcome is unclear. Therefore, this study aimed to evaluate whether vitamin D level or calcium intake modify the association between LD and various indices of bone health including bone mineral density (BMD) and Trabecular Bone Score (TBS). From The Rotterdam Study, a prospective population-based cohort study, we used data from 6990 participants aged > 45 year with a DXA scan (2002-2008), 6908 participants with femoral neck (FN)-BMD, 6677 participants with lumbar spine (LS)-BMD and 6476 participants with LS-TBS measurements. Use of LD was available from pharmacy dispensing records. Vitamin D (25(OH)D) level was measured in serum, and dietary calcium intake was measured with a validated food frequency questionnaire. Almost eight percent of the participants used LD. The association between LD (past-users compared to never-users) and LS-TBS was significantly different by 25(OH)D concentrations (P for interaction = 0.04). A significantly lower LS-TBS among LD past-users was observed for 25(OH)D ≥ 50 nmol/l compared to ≤ 20 and 20-50 nmol/l (β = - 0.036, 95% CI - 0.060; - 0.013 vs. β = - 0.012, 95% CI - 0.036; 0.013 and β = - 0.031, 95% CI - 0.096; 0.034, respectively). However, no other significant effect modification by 25(OH)D and dietary calcium intake was found in the associations between LD use and bone health outcomes (P-interaction > 0.13). This study suggests that the association between LD use and indices of bone health is not consistently modified by vitamin D or dietary calcium intake. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

123. Changing from a Western to a Mediterranean-style diet does not affect iron or selenium status: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) 1-year randomized clinical trial in elderly Europeans

Author

Jennings, Amy, Tang, Jonathan, Gillings, Rachel, Perfecto, Antonio, Dutton, John, Speakman, Jim, Fraser, William D, Nicoletti, Claudio, Berendsen, Agnes A M, de Groot, Lisette C P G M, Pietruszka, Barbara, Jeruszka-Bielak, Marta, Caumon, Elodie, Caille, Aurélie, Ostan, Rita, Franceschi, Claudio, Santoro, Aurelia, and Fairweather-Tait, Susan J

Subjects
ANALYSIS of covariance, BIOMARKERS, FISHES, INGESTION, IRON, MEAT, STATISTICAL sampling, SELENIUM, RANDOMIZED controlled trials, DATA analysis software, DESCRIPTIVE statistics, MEDITERRANEAN diet, ACTIVE aging, WESTERN diet
Abstract

Background Mediterranean diets limit red meat consumption and increase intakes of high-phytate foods, a combination that could reduce iron status. Conversely, higher intakes of fish, a good source of selenium, could increase selenium status. Objectives A 1-y randomized controlled trial [New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE)] was carried out in older Europeans to investigate the effects of consuming a Mediterranean-style diet on indices of inflammation and changes in nutritional status. Methods Selenium and iron intakes and status biomarkers were measured at baseline and after 1 y in 1294 people aged 65–79 y from 5 European countries (France, Italy, the Netherlands, Poland, and the United Kingdom) who had been randomly allocated either to a Mediterranean-style diet or to remain on their habitual, Western diet. Results Estimated selenium intakes increased significantly with the intervention group (P  < 0.01), but were not accompanied by changes in serum selenium concentrations. Iron intakes also increased (P  < 0.001), but there was no change in iron status. However, when stratified by study center, there were positive effects of the intervention on iron status for serum ferritin for participants in Italy (P  = 0.04) and France (P  = 0.04) and on soluble transferrin receptor (sTfR) for participants in Poland (P  < 0.01). Meat intake decreased and fish intake increased to a greater degree in the intervention group, relative to the controls (P  < 0.01 for both), but the overall effects of the intervention on meat and fish intakes were mainly driven by data from Poland and France. Changes in serum selenium in the intervention group were associated with greater changes in serum ferritin (P  = 0.01) and body iron (P  = 0.01), but not sTfR (P  = 0.73); there were no study center × selenium status interactions for the iron biomarkers. Conclusions Consuming a Mediterranean-style diet for 1 y had no overall effect on iron or selenium status, although there were positive effects on biomarkers of iron status in some countries. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

124. Cross-Sectional Analysis of the Correlation Between Daily Nutrient Intake Assessed by 7-Day Food Records and Biomarkers of Dietary Intake Among Participants of the NU-AGE Study

Author

Ostan, Rita, primary, Guidarelli, Giulia, additional, Giampieri, Enrico, additional, Lanzarini, Catia, additional, Berendsen, Agnes A. M., additional, Januszko, Olga, additional, Jennings, Amy, additional, Lyon, Noëlle, additional, Caumon, Elodie, additional, Gillings, Rachel, additional, Sicinska, Ewa, additional, Meunier, Nathalie, additional, Feskens, Edith J. M., additional, Pietruszka, Barbara, additional, de Groot, Lisette C. P. G. M., additional, Fairweather-Tait, Susan, additional, Capri, Miriam, additional, Franceschi, Claudio, additional, and Santoro, Aurelia, additional

Published
2018
Full Text
View/download PDF

125. Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci

Author

Munz, Matthias, primary, Richter, Gesa M., additional, Loos, Bruno G., additional, Jepsen, Søren, additional, Divaris, Kimon, additional, Offenbacher, Steven, additional, Teumer, Alexander, additional, Holtfreter, Birte, additional, Kocher, Thomas, additional, Bruckmann, Corinna, additional, Jockel-Schneider, Yvonne, additional, Graetz, Christian, additional, Ahmad, Ilyas, additional, Staufenbiel, Ingmar, additional, van der Velde, Nathalie, additional, Uitterlinden, André G., additional, de Groot, Lisette C. P. G. M, additional, Wellmann, Jürgen, additional, Berger, Klaus, additional, Krone, Bastian, additional, Hoffmann, Per, additional, Laudes, Matthias, additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Erdmann, Jeanette, additional, Dommisch, Henrik, additional, and Schaefer, Arne S., additional

Published
2018
Full Text
View/download PDF

126. A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

Author

Jennings, Amy, primary, Cashman, Kevin D, additional, Gillings, Rachel, additional, Cassidy, Aedin, additional, Tang, Jonathan, additional, Fraser, William, additional, Dowling, Kirsten G, additional, Hull, George L J, additional, Berendsen, Agnes A M, additional, de Groot, Lisette C P G M, additional, Pietruszka, Barbara, additional, Wierzbicka, Elzbieta, additional, Ostan, Rita, additional, Bazzocchi, Alberto, additional, Battista, Giuseppe, additional, Caumon, Elodie, additional, Meunier, Nathalie, additional, Malpuech-Brugère, Corinne, additional, Franceschi, Claudio, additional, Santoro, Aurelia, additional, and Fairweather-Tait, Susan J, additional

Published
2018
Full Text
View/download PDF

127. Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults

Author

Montiel Rojas, Diego, primary, Nilsson, Andreas, additional, Ponsot, Elodie, additional, Brummer, Robert J., additional, Fairweather-Tait, Susan, additional, Jennings, Amy, additional, de Groot, Lisette C. P. G. M., additional, Berendsen, Agnes, additional, Pietruszka, Barbara, additional, Madej, Dawid, additional, Caumon, Elodie, additional, Meunier, Nathalie, additional, Malpuech-Brugère, Corinne, additional, Guidarelli, Giulia, additional, Santoro, Aurelia, additional, Franceschi, Claudio, additional, and Kadi, Fawzi, additional

Published
2018
Full Text
View/download PDF

128. Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries

Author

Jeruszka-Bielak, Marta, primary, Kollajtis-Dolowy, Anna, additional, Santoro, Aurelia, additional, Ostan, Rita, additional, Berendsen, Agnes A. M., additional, Jennings, Amy, additional, Meunier, Nathalie, additional, Marseglia, Anna, additional, Caumon, Elodie, additional, Gillings, Rachel, additional, de Groot, Lisette C. P. G. M., additional, Franceschi, Claudio, additional, Hieke, Sophie, additional, and Pietruszka, Barbara, additional

Published
2018
Full Text
View/download PDF

133. Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial

Author

Marseglia, Anna, primary, Xu, Weili, additional, Fratiglioni, Laura, additional, Fabbri, Cristina, additional, Berendsen, Agnes A. M., additional, Bialecka-Debek, Agata, additional, Jennings, Amy, additional, Gillings, Rachel, additional, Meunier, Nathalie, additional, Caumon, Elodie, additional, Fairweather-Tait, Susan, additional, Pietruszka, Barbara, additional, De Groot, Lisette C. P. G. M., additional, Santoro, Aurelia, additional, and Franceschi, Claudio, additional

Published
2018
Full Text
View/download PDF

134. A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis

Author

Munz, Matthias, primary, Willenborg, Christina, additional, Richter, Gesa M, additional, Jockel-Schneider, Yvonne, additional, Graetz, Christian, additional, Staufenbiel, Ingmar, additional, Wellmann, Jürgen, additional, Berger, Klaus, additional, Krone, Bastian, additional, Hoffmann, Per, additional, van der Velde, Nathalie, additional, Uitterlinden, André G, additional, de Groot, Lisette C P G M, additional, Sawalha, Amr H, additional, Direskeneli, Haner, additional, Saruhan-Direskeneli, Güher, additional, Guzeldemir-Akcakanat, Esra, additional, Keceli, Huseyin Gencay, additional, Laudes, Matthias, additional, Noack, Barbara, additional, Teumer, Alexander, additional, Holtfreter, Birte, additional, Kocher, Thomas, additional, Eickholz, Peter, additional, Meyle, Jörg, additional, Doerfer, Christof, additional, Bruckmann, Corinna, additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Schreiber, Stefan, additional, Nohutcu, Rahime M, additional, Erdmann, Jeanette, additional, Loos, Bruno G, additional, Jepsen, Soeren, additional, Dommisch, Henrik, additional, and Schaefer, Arne S, additional

Published
2018
Full Text
View/download PDF

135. Joint Sequencing of Human and Pathogen Genomes Reveals the Genetics of Pneumococcal Meningitis

Author

Lees, John, primary, Ferwerda, Bart, additional, Kremer, Philip H. C., additional, Wheeler, Nicole E., additional, Serón, Mercedes Valls, additional, Croucher, Nicholas J., additional, Gladstone, Rebecca A., additional, Bootsma, Hester J., additional, Rots, Nynke, additional, Wijmega-Monsuur, Alienke J., additional, Sanders, Elisabeth A. M., additional, Trzciński, Krzysztof, additional, Wyllie, Anne L., additional, Zwinderman, Aeilko H., additional, van den Berg, Leonard H., additional, Rheenen, Wouter van, additional, Veldink, Jan H., additional, Harboe, Zitta B., additional, Lundbo, Lene F., additional, de Groot, Lisette C. P. G. M., additional, van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Ängquist, Lars H., additional, Sørensen, Thorkild I. A., additional, Nohr, Ellen A., additional, Mentzer, Alexander J., additional, Mills, Tara C., additional, Knight, Julian C., additional, Plessis, Mignon du, additional, Nzenze, Susan, additional, Weiser, Jeffrey N., additional, Parkhill, Julian, additional, Madhi, Shabir, additional, Benfield, Thomas, additional, von Gottberg, Anne, additional, van der Ende, Arie, additional, Brouwer, Matthijs C., additional, Barrett, Jeffrey C., additional, Bentley, Stephen D., additional, and van de Beek, Diederik, additional

Published
2018
Full Text
View/download PDF

137. Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

Author

Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Ching-Ti, Medina-Gomez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., Zemel, Babette S., Mitchell, Jonathan A., Taylor, Bruce, Lorentzon, Mattias, Karlsson, Magnus, Jaddoe, Vincent V. W., Tiemeier, Henning, Campos-Obando, Natalia, Franco, Oscar H., Utterlinden, Andre G., Broer, Linda, van Schoor, Natasja M., Ham, Annelies C., Ikram, M. Arfan, Karasik, David, de Mutsert, Renee, Rosendaal, Frits R., den Heijer, Martin, Wang, Thomas J., Lind, Lars, Orwoll, Eric S., Mook-Kanamori, Dennis O., Michaëlsson, Karl, Kestenbaum, Bryan, Ohlsson, Claes, Mellström, Dan K, de Groot, Lisette C. P. G. M., Grant, Struan F. A., Kiel, Douglas P., Zillikens, M. Carola, Rivadeneira, Fernando, Sawcer, Stephen, Timpson, Nicholas J., Richards, J. Brent, Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Ching-Ti, Medina-Gomez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., Zemel, Babette S., Mitchell, Jonathan A., Taylor, Bruce, Lorentzon, Mattias, Karlsson, Magnus, Jaddoe, Vincent V. W., Tiemeier, Henning, Campos-Obando, Natalia, Franco, Oscar H., Utterlinden, Andre G., Broer, Linda, van Schoor, Natasja M., Ham, Annelies C., Ikram, M. Arfan, Karasik, David, de Mutsert, Renee, Rosendaal, Frits R., den Heijer, Martin, Wang, Thomas J., Lind, Lars, Orwoll, Eric S., Mook-Kanamori, Dennis O., Michaëlsson, Karl, Kestenbaum, Bryan, Ohlsson, Claes, Mellström, Dan K, de Groot, Lisette C. P. G. M., Grant, Struan F. A., Kiel, Douglas P., Zillikens, M. Carola, Rivadeneira, Fernando, Sawcer, Stephen, Timpson, Nicholas J., and Richards, J. Brent

Abstract

Vitamin D insufficiency is common, correctable, and influenced by genetic factors, and it has been associated with risk of several diseases. We sought to identify low-frequency genetic variants that strongly increase the risk of vitamin D insufficiency and tested their effect on risk of multiple sclerosis, a disease influenced by low vitamin D concentrations. We used whole-genome sequencing data from 2,619 individuals through the UK10K program and deep-imputation data from 39,655 individuals genotyped genome-wide. Meta-analysis of the summary statistics from 19 cohorts identified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous coding variant g.14900931G>A (p.Asp120Asp) (rs117913124[A]), which conferred a large effect on 25-hydroxyvitamin D (25OHD) levels (-0.43 SD of standardized natural log-transformed 25OHD per A allele; p value = 1.5 x 10(-88)). The effect on 25OHD was four times larger and independent of the effect of a previously described common variant near CYP2R1. By analyzing 8,711 individuals, we showed that heterozygote carriers of this low-frequency variant have an increased risk of vitamin D insufficiency (odds ratio [OR] = 2.2, 95% confidence interval [CI] = 1.78-2.78, p = 1.26 3 10 x(-12)). Individuals carrying one copy of this variant also had increased odds of multiple sclerosis (OR = 1.4, 95% CI = 1.19-1.64, p = 2.63 3 10 x(-5)) in a sample of 5,927 case and 5,599 control subjects. In conclusion, we describe a low-frequency CYP2R1 coding variant that exerts the largest effect upon 25OHD levels identified to date in the general European population and implicates vitamin D in the etiology of multiple sclerosis.

Published
2017
Full Text
View/download PDF

138. Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults : A Meta-Analysis within the CHANCES Consortium

Author

Berendsen, Agnes A M, Kang, Jae H, van de Rest, Ondine, Jankovic, Nicole, Kampman, Ellen, Kiefte-de Jong, Jessica C, Franco, Oscar H, Ikram, M Arfan, Pikhart, Hynek, Nilsson, Lena Maria, Brenner, Hermann, Boffetta, Paolo, Rafnsson, Snorri Bjorn, Gustafson, Deborah, Kyrozis, Andreas, Trichopoulou, Antonia, Feskens, Edith J M, Grodstein, Francine, de Groot, Lisette C P G M, Berendsen, Agnes A M, Kang, Jae H, van de Rest, Ondine, Jankovic, Nicole, Kampman, Ellen, Kiefte-de Jong, Jessica C, Franco, Oscar H, Ikram, M Arfan, Pikhart, Hynek, Nilsson, Lena Maria, Brenner, Hermann, Boffetta, Paolo, Rafnsson, Snorri Bjorn, Gustafson, Deborah, Kyrozis, Andreas, Trichopoulou, Antonia, Feskens, Edith J M, Grodstein, Francine, and de Groot, Lisette C P G M

Abstract

AIM: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. METHODS: Data from 21,837 participants aged ≥55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action [SENECA], Rotterdam Study [RS], Nurses' Health Study [NHS]) were analyzed. HDI scores were based on intakes of saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, fruits and vegetables, and fiber. The Telephone Interview for Cognitive Status in NHS and Mini-Mental State Examination in RS and SENECA were used to assess cognitive function from multiple repeated measures. Using multivariable-adjusted, mixed linear regression, mean differences in annual rates of cognitive decline by HDI quintiles were estimated. RESULTS: Multivariable-adjusted differences in rates in the highest versus the lowest HDI quintile were 0.01 (95% CI -0.01, 0.02) in NHS, 0.00 (95% CI -0.02, 0.01) in RS, and 0.00 (95% CI -0.05, 0.05) in SENECA with a pooled estimate of 0.00 (95% CI -0.01, 0.01), I2 = 0%. CONCLUSIONS: A higher HDI score was not related to reduced rates of cognitive decline in European and American older adults.

Published
2017
Full Text
View/download PDF

139. Self-rated health and all-cause and cause-specific mortality of older adults : Individual data meta-analysis of prospective cohort studies in the CHANCES Consortium

Author

Bamia, Christina, Orfanos, Philippos, Juerges, Hendrik, Schoettker, Ben, Brenner, Hermann, Lorbeer, Roberto, Aadahl, Mette, Matthews, Charles E., Klinaki, Eleni, Katsoulis, Michael, Lagiou, Pagona, Bueno-de-mesquita, H. B., Eriksson, Sture, Mons, Ute, Saum, Kai-Uwe, Kubinova, Ruzena, Pajak, Andrzej, Tamosiunas, Abdonas, Malyutina, Sofia, Gardiner, Julian, Peasey, Anne, de Groot, Lisette C. P. G. M., Wilsgaard, Tom, Boffetta, Paolo, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Bamia, Christina, Orfanos, Philippos, Juerges, Hendrik, Schoettker, Ben, Brenner, Hermann, Lorbeer, Roberto, Aadahl, Mette, Matthews, Charles E., Klinaki, Eleni, Katsoulis, Michael, Lagiou, Pagona, Bueno-de-mesquita, H. B., Eriksson, Sture, Mons, Ute, Saum, Kai-Uwe, Kubinova, Ruzena, Pajak, Andrzej, Tamosiunas, Abdonas, Malyutina, Sofia, Gardiner, Julian, Peasey, Anne, de Groot, Lisette C. P. G. M., Wilsgaard, Tom, Boffetta, Paolo, Trichopoulou, Antonia, and Trichopoulos, Dimitrios

Abstract

Objectives: To evaluate, among the elderly, the association of self-rated health (SRH) with mortality, and to identify determinants of self-rating health as “at-least-good”. Study design: Individual data on SRH and important covariates were obtained for 424,791 European and United States residents, ≥60 years at recruitment (1982–2008), in eight prospective studies in the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). In each study, adjusted mortality ratios (hazard ratios, HRs) in relation to SRH were calculated and subsequently combined with random-effect meta-analyses. Main outcome measures: All-cause, cardiovascular and cancer mortality. Results: Within the median 12.5 years of follow-up, 93,014 (22%) deaths occurred. SRH “fair” or “poor” vs. “at-least-good” was associated with increased mortality: HRs 1.46 (95% CI 1·23–1.74) and 2.31 (1.79–2.99), respectively. These associations were evident: for cardiovascular and, to a lesser extent, cancer mortality, and within-study, within-subgroup analyses. Accounting for lifestyle, sociodemographic, somatometric factors and, subsequently, for medical history explained only a modest amount of the unadjusted associations. Factors favourably associated with SRH were: sex (males), age (younger-old), education (high), marital status (married/cohabiting), physical activity (active), body mass index (non-obese), alcohol consumption (low to moderate) and previous morbidity (absence). Conclusion: SRH provides a quick and simple tool for assessing health and identifying groups of elders at risk of early mortality that may be useful also in clinical settings. Modifying determinants of favourably rating health, e.g. by increasing physical activity and/or by eliminating obesity, may be important for older adults to “feel healthy” and “be healthy”.

Published
2017
Full Text
View/download PDF

140. Folate and vitamin B12-related biomarkers in relation to brain volumes

Author

van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, de Groot, Lisette C P G M, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, and de Groot, Lisette C P G M

Published
2017

141. Folate and vitamin B12-related biomarkers in relation to brain volumes

Author

Brain, Beeldverwerking ISI, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, de Groot, Lisette C P G M, Brain, Beeldverwerking ISI, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, and de Groot, Lisette C P G M

Published
2017

142. Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

Author

Hangelbroek, Roland W. J., Fazelzadeh, Parastoo, Tieland, Michael, Boekschoten, Mark V., Hooiveld, Guido J. E. J., van Duynhoven, John P. M., Timmons, James A., Verdijk, Lex B., de Groot, Lisette C. P. G. M., van Loon, Luc J. C., Müller, Michael, RS: NUTRIM - HB/BW section A, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, and Nutrition and Movement Sciences

Subjects
Male, Aging, Biopsy, Cadherin Related Proteins, Gene Expression, Skeletal muscle, Models, Biological, Humans, Muscle Strength, Muscle, Skeletal, Transcriptomics, Exercise, Aged, Aged, 80 and over, Muscle Weakness, Frailty, Gene Expression Profiling, Age Factors, Resistance Training, Original Articles, Cadherins, Healthy Volunteers, Ageing, Original Article, Female, Transcriptome
Abstract

BACKGROUND: The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre-)frail older adults. Additionally, we examine the effect of resistance-type exercise training on the muscle transcriptome in healthy older subjects and (pre-)frail older adults.METHODS: Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects. Follow-up samples from these frail older subjects (31 samples) and healthy older subjects (41 samples) were collected after 6 months of progressive resistance-type exercise training. Frail older subjects trained twice per week and the healthy older subjects trained three times per week.RESULTS: At baseline genes related to mitochondrial function and energy metabolism were differentially expressed between older and young subjects, as well as between healthy and frail older subjects. Three hundred seven genes were differentially expressed after training in both groups. Training affected expression levels of genes related to extracellular matrix, glucose metabolism ,and vascularization. Expression of genes that were modulated by exercise training was indicative of muscle strength at baseline. Genes that strongly correlated with strength belonged to the protocadherin gamma gene cluster (r = -0.73).CONCLUSION: Our data suggest significant remaining plasticity of ageing skeletal muscle to adapt to resistance-type exercise training. Some age-related changes in skeletal muscle gene expression appear to be partially reversed by prolonged resistance-type exercise training. The protocadherin gamma gene cluster may be related to muscle denervation and re-innervation in ageing muscle.

Published
2016

143. Alcoholic Beverage Preference and Dietary Habits in Elderly across Europe: Analyses within the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) Project

Author

Sluik, Diewertje Jankovic, Nicole O'Doherty, Mark G. Geelen, Anouk Schoettker, Ben Rolandsson, Olov Kiefte-de Jong, Jessica C. Ferrieres, Jean Bamia, Christina Fransen, Heidi P. Boer, Jolanda M. A. Eriksson, Sture Martinez, Begona and Maria Huerta, Jose Kromhout, Daan de Groot, Lisette C. P. G. M. and Franco, Oscar H. Trichopoulou, Antonia Boffetta, Paolo and Kee, Frank Feskens, Edith J. M.

Subjects
food and beverages
Abstract

Introduction The differential associations of beer, wine, and spirit consumption on cardiovascular risk found in observational studies may be confounded by diet. We described and compared dietary intake and diet quality according to alcoholic beverage preference in European elderly. Methods From the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES), seven European cohorts were included, i.e. four sub-cohorts from EPIC-Elderly, the SENECA Study, the Zutphen Elderly Study, and the Rotterdam Study. armonized data of 29,423 elderly participants from 14 European countries were analyzed. Baseline data on consumption of beer, wine, and spirits, and dietary intake were collected with questionnaires. Diet quality was assessed using the Healthy Diet Indicator (HDI). Intakes and scores across categories of alcoholic beverage preference (beer, wine, spirit, no preference, non-consumers) were adjusted for age, sex, socio-economic status, self reported prevalent diseases, and lifestyle factors. Cohort-specific mean intakes and scores were calculated as well as weighted means combining all cohorts. Results In 5 of 7 cohorts, persons with a wine preference formed the largest group. After multivariate adjustment, persons with a wine preference tended to have a higher HDI score and intake of healthy foods in most cohorts, but differences were small. The weighted estimates of all cohorts combined revealed that non-consumers had the highest fruit and vegetable intake, followed by wine consumers. Non-consumers and persons with no specific preference had a higher HDI score, spirit consumers the lowest. However, overall diet quality as measured by HDI did not differ greatly across alcoholic beverage preference categories. Discussion This study using harmonized data from similar to 30,000 elderly from 14 European countries showed that, after multivariate adjustment, dietary habits and diet quality did not differ greatly according to alcoholic beverage preference.

Published
2016

145. A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis

Author

Munz, Matthias, primary, Willenborg, Christina, additional, Richter, Gesa M, additional, Jockel-Schneider, Yvonne, additional, Graetz, Christian, additional, Staufenbiel, Ingmar, additional, Wellmann, Jürgen, additional, Berger, Klaus, additional, Krone, Bastian, additional, Hoffmann, Per, additional, van der Velde, Nathalie, additional, Uitterlinden, André G, additional, de Groot, Lisette C P G M, additional, Sawalha, Amr H, additional, Direskeneli, Haner, additional, Saruhan-Direskeneli, Güher, additional, Guzeldemir-Akcakanat, Esra, additional, Keceli, Huseyin Gencay, additional, Laudes, Matthias, additional, Noack, Barbara, additional, Teumer, Alexander, additional, Holtfreter, Birte, additional, Kocher, Thomas, additional, Eickholz, Peter, additional, Meyle, Jörg, additional, Doerfer, Christof, additional, Bruckmann, Corinna, additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Schreiber, Stefan, additional, Nohutcu, Rahime M, additional, Erdmann, Jeanette, additional, Loos, Bruno G, additional, Jepsen, Soeren, additional, Dommisch, Henrik, additional, and Schaefer, Arne S, additional

Published
2017
Full Text
View/download PDF

147. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Author

Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O., Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H., Rüeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C., Absher, Devin, Ahluwalia, Tarunveer S., Ahmad, Shafqat, Albrecht, Eva, Alves, Alexessander Couto, Bragg-Gresham, Jennifer L., de Craen, Anton J. M., Bis, Joshua C., Bonnefond, Amélie, Boucher, Gabrielle, Cadby, Gemma, Cheng, Yu-Ching, Chiang, Charleston W. K., Delgado, Graciela, Demirkan, Ayse, Dueker, Nicole, Eklund, Niina, Eiriksdottir, Gudny, Eriksson, Joel, Feenstra, Bjarke, Fischer, Krista, Frau, Francesca, Galesloot, Tessel E., Geller, Frank, Goel, Anuj, Gorski, Mathias, Grammer, Tanja B., Gustafsson, Stefan, Haitjema, Saskia, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jackson, Anne U., Jacobs, Kevin B., Johansson, Åsa, Kaakinen, Marika, Kleber, Marcus E., Lahti, Jari, Leach, Irene Mateo, Lehne, Benjamin, Liu, Youfang, Lo, Ken Sin, Lorentzon, Mattias, Luan, Jian'an, Madden, Pamela A. F., Mangino, Massimo, McKnight, Barbara, Medina-Gomez, Carolina, Monda, Keri L., Montasser, May E., Müller, Gabriele, Müller-Nurasyid, Martina, Nolte, Ilja M., Panoutsopoulou, Kalliope, Pascoe, Laura, Paternoster, Lavinia, Rayner, Nigel W., Renström, Frida, Rizzi, Federica, Rose, Lynda M., Ryan, Kathy A., Salo, Perttu, Sanna, Serena, Scharnagl, Hubert, Shi, Jianxin, Smith, Albert Vernon, Southam, Lorraine, Stančáková, Alena, Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Sung, Yun Ju, Tachmazidou, Ioanna, Tanaka, Toshiko, Thorleifsson, Gudmar, Trompet, Stella, Pervjakova, Natalia, Tyrer, Jonathan P., Vandenput, Liesbeth, van der Laan, Sander W, van der Velde, Nathalie, van Setten, Jessica, van Vliet-Ostaptchouk, Jana V., Verweij, Niek, Vlachopoulou, Efthymia, Waite, Lindsay L., Wang, Sophie R., Wang, Zhaoming, Wild, Sarah H., Willenborg, Christina, Wilson, James F., Wong, Andrew, Yang, Jian, Yengo, Loïc, Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Andersson, Ehm A., Bakker, Stephan J. L., Baldassarre, Damiano, Banasik, Karina, Barcella, Matteo, Barlassina, Cristina, Bellis, Claire, Benaglio, Paola, Blangero, John, Blüher, Matthias, Bonnet, Fabrice, Bonnycastle, Lori L., Boyd, Heather A., Bruinenberg, Marcel, Buchman, Aron S, Campbell, Harry, Chen, Yii-Der Ida, Chines, Peter S., Claudi-Boehm, Simone, Cole, John, Collins, Francis S., de Geus, Eco J. C., de Groot, Lisette C. P. G. M., Dimitriou, Maria, Duan, Jubao, Enroth, Stefan, Eury, Elodie, Farmaki, Aliki-Eleni, Forouhi, Nita G., Friedrich, Nele, Gejman, Pablo V., Gigante, Bruna, Glorioso, Nicola, Go, Alan S., Gottesman, Omri, Gräßler, Jürgen, Grallert, Harald, Grarup, Niels, Gu, Yu-Mei, Broer, Linda, Ham, Annelies C., Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas, Hattersley, Andrew T., Heath, Andrew C., Henders, Anjali K., Hernandez, Dena, Hillege, Hans, Holmen, Oddgeir, Hovingh, Kees G, Hui, Jennie, Husemoen, Lise L., Hutri-Kähönen, Nina, Hysi, Pirro G., Illig, Thomas, De Jager, Philip L., Jalilzadeh, Shapour, Jørgensen, Torben, Jukema, J. Wouter, Juonala, Markus, Kanoni, Stavroula, Karaleftheri, Maria, Khaw, Kay Tee, Kinnunen, Leena, Kittner, Steven J., Koenig, Wolfgang, Kolcic, Ivana, Kovacs, Peter, Krarup, Nikolaj T., Kratzer, Wolfgang, Krüger, Janine, Kuh, Diana, Kumari, Meena, Kyriakou, Theodosios, Langenberg, Claudia, Lannfelt, Lars, Lanzani, Chiara, Lotay, Vaneet, Launer, Lenore J., Leander, Karin, Lindström, Jaana, Linneberg, Allan, Liu, Yan-Ping, Lobbens, Stéphane, Luben, Robert, Lyssenko, Valeriya, Männistö, Satu, Magnusson, Patrik K., McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Milani, Lili, Montgomery, Grant W., Morris, Andrew P., Narisu, Narisu, Nelis, Mari, Ong, Ken K., Palotie, Aarno, Pérusse, Louis, Pichler, Irene, Pilia, Maria G., Pouta, Anneli, Rheinberger, Myriam, Ribel-Madsen, Rasmus, Richards, Marcus, Rice, Kenneth M., Rice, Treva K., Rivolta, Carlo, Salomaa, Veikko, Sanders, Alan R., Sarzynski, Mark A., Scholtens, Salome, Scott, Robert A., Scott, William R., Sebert, Sylvain, Sengupta, Sebanti, Sennblad, Bengt, Seufferlein, Thomas, Silveira, Angela, Slagboom, P. Eline, Smit, Jan H., Sparsø, Thomas H., Stirrups, Kathleen, Stolk, Ronald P., Stringham, Heather M., Swertz, Morris A, Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Tsafantakis, Emmanouil, van der Most, Peter J., Völker, Uwe, Vohl, Marie-Claude, Vonk, Judith M., Waldenberger, Melanie, Walker, Ryan W., Wennauer, Roman, Widén, Elisabeth, Willemsen, Gonneke, Wilsgaard, Tom, Wright, Alan F., Zillikens, M. Carola, van Dijk, Suzanne C., van Schoor, Natasja M., Asselbergs, Folkert W., de Bakker, Paul I. W., Beckmann, Jacques S., Beilby, John, Bennett, David A., Bergman, Richard N., Bergmann, Sven, Böger, Carsten A., Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Chambers, John C., Chanock, Stephen J., Chasman, Daniel I., Cucca, Francesco, Cusi, Daniele, Dedoussis, George, Erdmann, Jeanette, Eriksson, Johan G., Evans, Denis A., de Faire, Ulf, Farrall, Martin, Ferrucci, Luigi, Ford, Ian, Franke, Lude, Franks, Paul W., Froguel, Philippe, Gansevoort, Ron T., Gieger, Christian, Grönberg, Henrik, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Per, Hamsten, Anders, van der Harst, Pim, Hayward, Caroline, Heliövaara, Markku, Hengstenberg, Christian, Hicks, Andrew A, Hingorani, Aroon, Hofman, Albert, Hu, Frank, Huikuri, Heikki V., Hveem, Kristian, James, Alan L., Jordan, Joanne M., Jula, Antti, Kähönen, Mika, Kajantie, Eero, Kathiresan, Sekar, Kiemeney, Lambertus A. L. M., Kivimaki, Mika, Knekt, Paul B., Koistinen, Heikki A., Kooner, Jaspal S., Koskinen, Seppo, Kuusisto, Johanna, Maerz, Winfried, Martin, Nicholas G, Laakso, Markku, Lakka, Timo A., Lehtimäki, Terho, Lettre, Guillaume, Levinson, Douglas F., Lind, Lars, Lokki, Marja-Liisa, Mäntyselkä, Pekka, Melbye, Mads, Metspalu, Andres, Mitchell, Braxton D., Moll, Frans L., Murray, Jeffrey C., Musk, Arthur W., Nieminen, Markku S., Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Oostra, Ben A., Palmer, Lyle J, Pankow, James S., Pasterkamp, Gerard, Pedersen, Nancy L., Pedersen, Oluf, Penninx, Brenda W., Perola, Markus, Peters, Annette, Polašek, Ozren, Pramstaller, Peter P., Psaty, Bruce M., Qi, Lu, Quertermous, Thomas, Raitakari, Olli T., Rankinen, Tuomo, Rauramaa, Rainer, Ridker, Paul M., Rioux, John D., Rivadeneira, Fernando, Rotter, Jerome I., Rudan, Igor, den Ruijter, Hester M., Saltevo, Juha, Sattar, Naveed, Schunkert, Heribert, Schwarz, Peter E. H., Shuldiner, Alan R., Sinisalo, Juha, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Staessen, Jan A., Stefania, Bandinelli, Thorsteinsdottir, Unnur, Stumvoll, Michael, Tardif, Jean-Claude, Tremoli, Elena, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, Verbeek, André L. M., Vermeulen, Sita H., Viikari, Jorma S., Vitart, Veronique, Völzke, Henry, Vollenweider, Peter, Waeber, Gérard, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Zeggini, Eleftheria, Chakravarti, Aravinda, Clegg, Deborah J., Cupples, L. Adrienne, Gordon-Larsen, Penny, Jaquish, Cashell E., Rao, D. C., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Inês, Berndt, Sonja I., Boehnke, Michael, Deloukas, Panos, Fox, Caroline S., Groop, Leif C., Hunter, David J., Ingelsson, Erik, Kaplan, Robert C., McCarthy, Mark I., Mohlke, Karen L., O'Connell, Jeffrey R., Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Hirschhorn, Joel N., Lindgren, Cecilia M., Heid, Iris M., North, Kari E., Borecki, Ingrid B., Kutalik, Zoltán, and Loos, Ruth J. F.

Subjects
ddc
Published
2015

148. Exogenous insulin does not increase muscle protein synthesis rate when administered systemically: A systematic review

Author

Trommelen, Jorn, Groen, Bart B. L., Hamer, Henrike M., de Groot, Lisette C. P. G. M., and van Loon, Luc J. C.

Abstract

Background: Though it is well appreciated that insulin plays an important role in the regulation of muscle protein metabolism, there is much discrepancy in the literature on the capacity of exogenous insulin administration to increase muscle protein synthesis rates in vivo in humans. Objective: To assess whether exogenous insulin administration increases muscle protein synthesis rates in young and older adults. Design: A systematic review of clinical trials was performed and the presence or absence of an increase in muscle protein synthesis rate was reported for each individual study arm. In a stepwise manner, multiple models were constructed that excluded study arms based on the following conditions: model 1, concurrent hyperaminoacidemia; model 2, insulin-induced hypoaminoacidemia; model 3, supraphysiological insulin concentrations; and model 4, older, more insulin resistant, subjects. Conclusions: From the presented data in the current systematic review, we conclude that: i) exogenous insulin and amino acid administration effectively increase muscle protein synthesis, but this effect is attributed to the hyperaminoacidemia; ii) exogenous insulin administered systemically induces hypoaminoacidemia which obviates any insulin-stimulatory effect on muscle protein synthesis; iii) exogenous insulin resulting in supraphysiological insulin levels exceeding 50 000 pmol/l may effectively augment muscle protein synthesis; iv) exogenous insulin may have a diminished effect on muscle protein synthesis in older adults due to age-related anabolic resistance; and v) exogenous insulin administered systemically does not increase muscle protein synthesis in healthy, young adults.

Published
2015

149. The association between apathy, decline in physical performance, and falls in older persons.

Author

Henstra, Marieke J., Rhebergen, Didi, Stek, Max L., Swart, Karin M. A., van Dijk, Suzanne C., Zillikens, M. Carola, Oliai Araghi, Sadaf, de Groot, Lisette C. M. G. M., van Schoor, Natasja M., and van der Velde, Nathalie

Abstract

Background: Symptoms of apathy are common in older persons. Negative effects on physical performance and fall risk are plausible, considering the pathophysiology of apathy. However, literature is scarce. Aim: To longitudinally assess the association between apathy and (1) decline of physical performance and (2) the number of falls in older community-dwelling persons. Methods: The 'B vitamins for the PRevention Of Osteoporotic Fractures' study provided data on 2919 older persons over a period of 2 years. Apathy was assessed using the Geriatric Depression Scale 3. A physical performance score (PPS) was calculated using three performance tests. Falls were registered prospectively. We calculated adjusted odds ratios (ORs), Incidence Rate Ratios (IRRs), and their 95% confidence intervals. Effect modification by age and gender was investigated. We also investigated mediation by baseline PPS for the association between apathy and the number of falls. Results: Apathy and decline of PPS were independently associated. After stratification, the effect only remained in men. Age was an effect modifier; higher ORs for decreasing age. Apathy was also independently associated with the number of falls. After stratification, women had higher IRRs than men. Age modified the association in the opposite direction: higher IRRs for increasing age. Baseline PPS was a mediator in the association. Conclusion: The impact of apathy on physical performance and fall incidents varied with age and gender. Potentially, in older individuals with apathy, fall risk is preceded by a decline in physical performance. In clinical practice, identifying apathy in older persons might be useful to target mobility preserving interventions. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

150. The association between 25-hydroxyvitamin D concentration, physical performance and frailty status in older adults.

Author

Brouwer-Brolsma, Elske M., Toussaint, Nicole, de Regt, Margot, Vaes, Anouk M. M., Tieland, Michael, de Groot, Lisette C. P. G. M., and van Loon, Luc J. C.

Subjects
KNEE physiology, FRAIL elderly, GRIP strength, RANGE of motion of joints, VITAMIN D, VITAMIN D deficiency, MULTIPLE regression analysis, BODY movement, CROSS-sectional method, WALKING speed, OLD age
Abstract

Purpose: Sufficient 25-hydroxyvitamin D (25(OH)D) concentrations might prevent a decline in physical performance, and are considered important for the prevention of frailty. This study investigates the association of serum 25(OH)D concentration with physical performance and frailty status in Dutch older adults. Methods: This cross-sectional study included 756 men and women, aged ≥ 65 years. Serum 25(OH)D concentration and frailty status (Fried criteria) were assessed in the total population. Screening for frailty status included functional tests of gait speed and hand grip strength. In a subgroup (n = 494), the Timed Up and Go test (TUG) and knee-extension strength were measured. Associations of serum 25(OH)D status with physical performance were examined by multiple linear regression. Prevalence ratios (PR) were used to quantify associations between serum 25(OH)D deficiency (< 50 nmol/L) and frailty. Results: In total, 45% of the participants were vitamin D deficient. Participants with vitamin D status < 50 and 50–75 nmol/L had significantly lower scores on the TUG and gait speed test, compared to participants with vitamin D status > 75 nmol/L. No significant associations with serum 25(OH)D concentrations were observed for handgrip strength or knee-extension strength. Participants with serum 25(OH)D status < 50 nmol/L were about two times more likely to be frail compared to participants with serum 25(OH)D status ≥ 50 nmol/L. No significant associations were observed between the pre-frail state and serum 25(OH)D status. Conclusion: In this study, serum 25(OH)D concentrations were significantly associated with frailty status and measures of physical performance, including gait speed and TUG, but not with strength-related outcomes. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results