305 results on '"Yuan Gan"'
Search Results
102. 3D Shape Segmentation Based on Viewpoint Entropy and Projective Fully Convolutional Networks Fusing Multi-view Features
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Bingyang Hu, Pengyu Wang, Yuan Gan, Fenggen Yu, Panpan Shui, Yan Zhang, and Kun Liu
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Pixel ,business.industry ,Computer science ,Entropy (statistical thermodynamics) ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,020207 software engineering ,Pattern recognition ,02 engineering and technology ,Image segmentation ,Upsampling ,Cut ,0202 electrical engineering, electronic engineering, information engineering ,Entropy (information theory) ,020201 artificial intelligence & image processing ,Segmentation ,Artificial intelligence ,Projective test ,Entropy (energy dispersal) ,business ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
This paper introduces an architecture for segmenting 3D shapes into labeled semantic parts. Our architecture combines viewpoint selection method based on viewpoint entropy, multi-view image-based Fully Convolutional Networks (FCNs) and graph cuts optimization method to yield coherent segmentation of 3D shapes. First, we select iteratively a fixed number of perspectives with the maximum viewpoint entropy from existing viewpoints that can cover the shape's triangles, to maximally and automatically adjust the distance between the viewpoint and the center point of the shape to make sure the shape projected to fill the render window as wide as possible. Second, the image-based FCN is used for efficient view-based reasoning about 3D shape parts. In this process, global features generated by max view pooling are concatenated with every single view's feature in the fully connected layer before upsampling. Then, the multi-view FCN outputs confidence maps per part, which are then input into the projection layer that contains the mapping relationship of every shape's triangles and their projective pixels' positions in the rendered images from selected perspectives. And then, the FCN outputs are projected back onto 3D shape surfaces. and max view pooling is applied to the output of the projection layer so that every triangle of each shape has a unique probability for each label. Finally, graph cuts algorithm is implemented for the final segmentation result.
- Published
- 2018
103. Unusual phonon density of states and response to the superconducting transition in the In-doped topological crystalline insulator Pb0.5Sn0.5Te
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Tong Chen, Barry Winn, Guangyong Xu, Zhengwei Cai, Song Bao, Ruidan Zhong, Kejing Ran, Zhen Ma, John M. Tranquada, Yuan Gan, Jian Sun, Shichao Li, Genda Gu, Jinsheng Wen, Jinghui Wang, and Andrew D. Christianson
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Superconductivity ,Physics ,Phonon ,Doping ,02 engineering and technology ,BCS theory ,021001 nanoscience & nanotechnology ,Topology ,01 natural sciences ,Omega ,Inelastic neutron scattering ,Electrical resistivity and conductivity ,Condensed Matter::Superconductivity ,0103 physical sciences ,Density functional theory ,010306 general physics ,0210 nano-technology - Abstract
We present inelastic neutron scattering results of phonons in ${({\mathrm{Pb}}_{0.5}{\mathrm{Sn}}_{0.5})}_{1\ensuremath{-}x}{\mathrm{In}}_{x}\mathrm{Te}$ powders, with $x=0$ and 0.3. The $x=0$ sample is a topological crystalline insulator, and the $x=0.3$ sample is a superconductor with a bulk superconducting transition temperature ${T}_{c}$ of 4.7 K. In both samples, we observe unexpected van Hove singularities in the phonon density of states at energies of 1--2.5 meV, suggestive of local modes. On cooling the superconducting sample through ${T}_{c}$, there is an enhancement of these features for energies below twice the superconducting-gap energy. We further note that the superconductivity in ${({\mathrm{Pb}}_{0.5}{\mathrm{Sn}}_{0.5})}_{1\ensuremath{-}x}{\mathrm{In}}_{x}\mathrm{Te}$ occurs in samples with normal-state resistivities of order 10 $\mathrm{m}\mathrm{\ensuremath{\Omega}}\phantom{\rule{0.16em}{0ex}}\mathrm{cm}$, indicative of bad-metal behavior. Calculations based on density functional theory suggest that the superconductivity is easily explainable in terms of electron-phonon coupling; however, they completely miss the low-frequency modes and do not explain the large resistivity. While the bulk superconducting state of ${({\mathrm{Pb}}_{0.5}{\mathrm{Sn}}_{0.5})}_{0.7}{\mathrm{In}}_{0.3}\mathrm{Te}$ appears to be driven by phonons, a proper understanding will require ideas beyond simple BCS theory.
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- 2018
104. The general facilitation effect of implementation intentions on prospective memory performance in patients with schizophrenia
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Tao Chen, Shuping Tan, Ji-fang Cui, Ya Wang, Lu-lu Liu, Raymond C.K. Chan, David L. Neumann, David Shum, and Ming-yuan Gan
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Adult ,Male ,medicine.medical_specialty ,Memory, Episodic ,Cognitive Neuroscience ,Intention ,Audiology ,050105 experimental psychology ,Task (project management) ,Time-Based Prospective Memory ,03 medical and health sciences ,0302 clinical medicine ,Prospective memory ,medicine ,Humans ,0501 psychology and cognitive sciences ,In patient ,Implementation intention ,05 social sciences ,medicine.disease ,Psychiatry and Mental health ,Schizophrenia ,Mental Recall ,Facilitation ,Female ,Schizophrenic Psychology ,Psychology ,Photic Stimulation ,Psychomotor Performance ,030217 neurology & neurosurgery - Abstract
Introduction: Prospective memory (PM) refers to remembering to execute a planned intention in the future. It can be divided into event- and time-based, according to the nature of the PM cue. Event-based PM cues can be classified as focal or non-focal. Patients with schizophrenia (SCZ) have been found to be impaired in both event- and time-based PM. PM has been found to be improved by implementation intentions, which is an encoding strategy in the format of “if X then Y”. This study examined the effect of implementation intentions on a non-focal event-based and a time-based PM task in patients with SCZ.Methods: Forty-two patients with SCZ and 42 healthy controls were allocated to either an implementation intention or a control PM instruction condition and were asked to complete two PM tasks. Results: Implementation intentions was found to improve performance in both the non-focal event-based and time-based PM tasks in patients with SCZ and healthy controls, with no costs to the ongoing task. The improvement in time-based PM performance in the implementation intentions condition was partially mediated by the frequency of clock checking behaviour. Conclusions: Implementation intentions can facilitate PM performance in patients with SCZ and has the potential to be used as a clinical intervention tool.
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- 2018
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105. Design, synthesis and anti-bacterial evaluation of novel 1,3,4-thiadiazole derivatives bearing a semicarbazone moiety
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Kun Tian, Gui-Ping Ouyang, Jiao Meng, Jin-Lin Wan, Zhenchao Wang, Yang Xu, Shou-Qun Wu, Xiao-Qin Li, Yi-Yuan Gan, and Wei-nan Hu
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Indole test ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,food and beverages ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Xanthomonas oryzae ,Design synthesis ,Xanthomonas ,1 3 4 thiadiazole derivatives ,Moiety ,Anti bacterial ,Semicarbazone - Abstract
Novel 1,3,4-thiadiazole derivatives bearing a semicarbazone moiety were prepared and evaluated for their anti-bacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) by performing a turbidimetre test. The products were structurally characterised by IR, 1H NMR, 13C NMR, 19F NMR and HRMS. Anti-bacterial testing showed that most of the evaluated compounds (6a-6s) exhibited excellent activity (≥74.19%) against Xoo at a concentration of 200 µg/mL, with 50% effective concentration (EC50) values ranging from 12.21 to 67.20 µg/mL, which were superior to the commercial antibacterial agent bismerthiazol (92.23 µg/mL). Among them, compound 2-((2-chloro-1H-indol-3-yl)methylene)-N-(5-((2-chlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide (6b) demonstrated good inhibitory activity against Xac (89.46% at 200 µg/mL) and Xoo (EC50 = 18.28 µg/mL); compound 2-((2-chloro-1H-indol-3-yl)methylene)-N-(5-((4-methoxybenzyl)thio)-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide (6g) displayed excellent activity against Xoo with EC50 value of 12.21 µg/mL.
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- 2018
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106. Multi-carrier transport in ZrTe5 film
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Yuan Gan, Peipei Wang, Wei Zhang, Fangdong Tang, Le Wang, Liyuan Zhang, and Peng Wang
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Electron mobility ,Materials science ,Condensed Matter - Mesoscale and Nanoscale Physics ,business.industry ,General Physics and Astronomy ,Multi carrier ,FOS: Physical sciences ,02 engineering and technology ,Crystal structure ,021001 nanoscience & nanotechnology ,01 natural sciences ,Zirconium compounds ,Charge-carrier density ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,Optoelectronics ,Thin film ,010306 general physics ,0210 nano-technology ,business ,Tellurium compounds - Abstract
The single layer of Zirconium pentatelluride (ZrTe5) has been predicted to be a large-gap two-dimensional (2D) topological insulator, which has attracted particular attention in the topological phase transitions and potential device application. Here we investigated the transport properties in ZrTe5 films with the dependence of thickness from a few nm to several hundred nm. We find that the temperature of the resistivity anomaly's peak (Tp) is inclining to increase as the thickness decreases, and around a critical thickness of ~40 nm, the dominating carriers in the films change from n-type to p-type. With comprehensive studying of the Shubnikov-de Hass (SdH) oscillations and Hall resistance at variable temperatures, we demonstrate the multi-carrier transport instinct in the thin films. We extract the carrier densities and mobilities of two majority carriers using the simplified two-carrier model. The electron carriers can be attributed to the Dirac band with a non-trivial Berry's phase {\pi}, while the hole carriers may originate from the surface chemical reaction or unintentional doping during the microfabrication process. It is necessary to encapsulate ZrTe5 film in the inert or vacuum environment to make a substantial improvement in the device quality.
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- 2018
- Full Text
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107. Research on the Performance of Land Transfer Based on GIS System
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Xiao-feng Duan, Hong-nan Kuai, Yuan Gan, Xue-guang Yuan, Yang-an Zhang, Zuo Yong, and Zhang Jinnan
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Land use ,Work (electrical) ,Land transfer ,Agriculture ,business.industry ,Cadastre ,Resource management ,Circulation (currency) ,business ,Land resources ,Environmental planning - Abstract
Rural land circulation is a hot topic of land resource management and research. It involves the nature of land use changes, land changes, cadastral ownership relations change and many other content, with the aid of GIS technology can be efficient, high-quality completion of these work. Based on the scientific, practical and reliable principles, this paper realized a visible system of abstract data about rural land circulation by coupling the comprehensive performance evaluation model of rural land circulation with GIS Technology. According to this system, we are able to analyse the impact of land transfer on society. Furthermore, the analysis mentioned above affords strong theoretical foundation for agricultural sector to make decisions. Finally, based on the rural land circulation data of specific township, the system is applied to analyse the impact of land transfer on this town then change the allocation of land resources for better in the future.
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- 2017
108. A Study of GIS-based Rural Land Approval Agglomeration and Economic Growth in China
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Hong-nan Kuai, Yuan Gan, Zhang Jinnan, Zuo Yong, Hang Shao, Xue-guang Yuan, and Yang-an Zhang
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Land contract ,Geographic information system ,Work (electrical) ,business.industry ,Agriculture ,Economies of agglomeration ,Regional science ,Distribution (economics) ,Certification ,China ,business - Abstract
The No.1 Document of the Party Central Committee put forward to carry out a comprehensive rural land approval registration certification work in 2013. In response to the call, the Ministry of Agriculture accelerate the development of rural land approval registration certification work, to further stabilize the land contract relations, promote land transfer and scale development, add new energy for the agriculture development. By 2016, more than 90% of the country had already carried out land approval work, so this paper employs the rural land approval data to study economy growth on the role of rural land approval agglomeration in most provinces of China in 2016. With applying the geographic information systems in the application, forecasting the model of rural land approval and economic growth is the inevitable trend in development. This article in view of spatial information systems researching in the rural land approval distribution is to make prediction of the toughest task. The results show that rural land approval agglomeration has a significant positive role in the regional economic growth in different models divided by two groups. Then we use universal Kriging prediction model to analysis and validate the correction.
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- 2017
109. A novel four-step approach for systematic identification of naphthoquinones in Juglans cathayensis dode using various scan functions of liquid chromatography-tandem mass spectrometry along with data mining strategies
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Chengwu Song, Han-Li Ruan, Yong Xu, Hongliang Jiang, Chang Chen, Yang Zhang, Aiqian Li, and Yuan Gan
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Chromatography ,Chemistry ,Plant Science ,General Medicine ,Tandem mass spectrometry ,computer.software_genre ,Biochemistry ,Mass measurement ,Analytical Chemistry ,Complementary and alternative medicine ,Liquid chromatography–mass spectrometry ,Drug Discovery ,Lc ms ms ,Molecular Medicine ,Data mining ,computer ,Food Science ,Ion trap mass spectrometry - Abstract
Introduction Systematic analyses of naphthoquinones in Juglans cathayensis have not yet been reported. It is very challenging to identify naphthoquinones with various structural diversities, especially those at trace levels. Objective To develop an efficient analytical approach for systematic discovery and identification of naphthoquinones in Juglans cathayensis. Methodology A novel four-step approach was evaluated by utilizing various scan functions of liquid chromatography-triple quadrupole-linear ion trap mass spectrometry (LC-QTRAP-MS/MS) and liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS) along with data mining strategies. First, MS/MS fragmentation behaviors of naphthoquinones were investigated. Second, multiple ion monitoring triggered enhanced product ion scan (MIM-EPI) with specified ions was conducted to identify targeted naphthoquinones. Third, other scan functions of QTRAP-MS/MS and data mining strategies were explored to identify untargeted naphthoquinones. Fourth, structural rationalization and confirmation of naphthoquinones were performed using QTOF-MS/MS via its accurate mass measurement and MS/MS fragmentation functions. Results Optimal scan methods and data mining strategies using QTRAP-MS/MS were obtained for identification of targeted and untargeted naphthoquinones. Consequently, 48 naphthoquinones including 24 novel ones were identified or tentatively identified from Juglans cathayensis. Conclusion A novel four-step approach for efficient discovery and identification of naphthoquinones was developed by exploring various scan functions of current LC-MS/MS technologies and data mining strategies, providing an example for systematic characterization of certain classes of phytochemicals, especially trace analytes in complex samples. Copyright © 2015 John Wiley & Sons, Ltd.
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- 2015
110. Measurement and quantitative analysis of fiber orientation distribution in long fiber reinforced part by injection molding
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John Lasecki, Xuming Su, Yuan Gan, Danielle Zeng, Jie Tao, and Xianjun Sun
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Core (optical fiber) ,Orientation tensor ,Materials science ,Polymers and Plastics ,Plane (geometry) ,Organic Chemistry ,Physics::Optics ,Tensor ,Fiber ,Composite material ,Microstructure ,Layer (electronics) ,Molding (decorative) - Abstract
The fiber orientation distribution is one of the important microstructure variables for thermoplastic composites reinforced with discontinuous fibers. In this paper, the long fibers in the injection molded part are measured in detail by micro X-ray CT. A three dimensional (3D) structure of the sample is built and two dimensional images are generated for image analysis. The orientation tensor of fibers is calculated in the flow plane. It shows a symmetric distribution of fibers through the thickness direction, which consists of outer skin, transition zone and the core. The skin layer is so thin that it has only one layer of highly oriented fibers. The core layer also has highly oriented fibers but the direction of fibers is different from that in the skin layer. Nevertheless, the clustering of the fibers is characterized quantitatively in the core. The transition zone can be divided into two subzones by the principal directions of the tensor.
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- 2015
111. The effect of implementation intention on prospective memory: A systematic and meta-analytic review
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Lu-lu Liu, Ming-yuan Gan, Ya Wang, Raymond C.K. Chan, Ji-fang Cui, David Shum, and Xing-jie Chen
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Implementation intention ,Memory, Episodic ,Large effect size ,Applied psychology ,Age Factors ,Intention ,Psychiatry and Mental health ,Action (philosophy) ,Meta-analysis ,Prospective memory ,Imagination ,Reaction Time ,Humans ,Prospective Studies ,Psychology ,Task Performances ,Social psychology ,Psychomotor Performance ,Biological Psychiatry - Abstract
Prospective memory (PM) refers to remembering to perform a planned action at a future time. Implementation intention is an encoding method in the form of "if situation Y is encountered, then I will initiate the goal-directed behavior X". It has been applied to improve PM performances. The present study conducted a systematic and meta-analytic review on the effect and mechanism of implementation intention on PM. In the meta-analysis, 36 comparisons were included. The results showed that for healthy young adults, the overall effect of implementation intention in improving PM performances was significant with a medium effect size (d = 0.445). The combined verbal and imagery form of implementation intention had a relatively larger effect size (d = 0.590). For older adults, implementation intention had a medium to large effect size on their PM performances (d = 0.680). As for the mechanism, implementation intention seemed to reduce ongoing task performances in young adults as reflected by longer reaction time (d = 0.224) though the effect size was small. The present study supports the positive effect of implementation intention on PM. The mechanism and potential implications of this promising strategy especially for clinical/sub-clinical people are discussed.
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- 2015
112. Application of Biopartioning Micellar Chromatography in Screening Active Ingredients of Traditional Chinese Medicine
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Jin Tao Xue, Xin Yu Yan, Ting Xu, Yuan Gan, Li-Ming Ye, Yan Liang, Han Chen, Yu Chen, Cong Chen, and Dong Mei Xiong
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Active ingredient ,Chromatography ,Chemistry ,General Chemistry ,Traditional Chinese medicine - Published
- 2015
113. Protecting Distance of Scattering between DC Transmission Line and Receiving Station of AM
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Bo Tang, Xing Fa Liu, Zhe Yuan Gan, and Jian Gong Zhang
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Engineering ,business.industry ,Frequency band ,Transmission line ,Ground ,Reradiation ,Line (geometry) ,Electrical engineering ,General Medicine ,Broadcasting ,business ,Interference (wave propagation) ,Power (physics) - Abstract
In the construction of UHVDC power line in China, the national standard of reradiation interference protecting distance between UHVDC power line and receiving station of AM broadcasting needs to be renewed. In this paper, the wire-surface simulation model is used to calculate the interference. In the model, steel tower is represented as surface model, ground wire is represented as wire model, and the whole model is excitated by vertical polarization plane wave. For the deficiency of traditional solution method of protecting distance calculation, a new method is proposed. It is recommended that the whole work frequency band of receiving station should be calculated to determine the space interval which has actual protecting distance. Then the interval is gradually narrowed with dichotomy method until the interval size is within allowable value. With the first-grade receiving station of AM broadcasting as example, the reradiation interference protecting distance from UHVDC power line and station is calculated..
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- 2014
114. Suppression of the antiferromagnetic order when approaching the superconducting state in a phase-separated crystal of KxFe2−ySe2
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J. Schneeloch, Wei Tian, Shichao Li, Jinsheng Wen, Matthew B. Stone, Qiang Li, Ph. Bourges, Genda Gu, Jinghui Wang, Songxue Chi, John M. Tranquada, Yuan Gan, Ruidan Zhong, Guangyong Xu, Y. Sidis, Masaaki Matsuda, Robert J. Birgeneau, and Zhijun Xu
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Superconducting coherence length ,Superconductivity ,Physics ,Condensed matter physics ,Neutron diffraction ,02 engineering and technology ,Inelastic scattering ,021001 nanoscience & nanotechnology ,01 natural sciences ,Magnetic susceptibility ,Inelastic neutron scattering ,Condensed Matter::Superconductivity ,0103 physical sciences ,Proximity effect (superconductivity) ,Antiferromagnetism ,010306 general physics ,0210 nano-technology - Abstract
Author(s): Li, S; Gan, Y; Wang, J; Zhong, R; Schneeloch, JA; Xu, Z; Tian, W; Stone, MB; Chi, S; Matsuda, M; Sidis, Y; Bourges, P; Li, Q; Gu, G; Tranquada, JM; Xu, G; Birgeneau, RJ; Wen, J | Abstract: We have combined elastic and inelastic neutron scattering techniques, magnetic susceptibility, and resistivity measurements to study single-crystal samples of KxFe2-ySe2, which contain the superconducting phase that has a transition temperature of ∼31 K. In the inelastic neutron scattering measurements, we observe both the spin-wave excitations resulting from the block antiferromagnetic ordered phase and the resonance that is associated with the superconductivity in the superconducting phase, demonstrating the coexistence of these two orders. From the temperature dependence of the intensity of the magnetic Bragg peaks, we find that well before entering the superconducting state, the development of the magnetic order is interrupted, at ∼42 K. We consider this result to be evidence for the physical separation of the antiferromagnetic and superconducting phases; the suppression is possibly due to the proximity effect of the superconducting fluctuations on the antiferromagnetic order.
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- 2017
115. Decompression‐Driven Superconductivity Enhancement in In 2 Se 3
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Yuan Gan, Viktor V. Struzhkin, Yabin Chen, Haini Dong, Xiao-Jia Chen, Wenge Yang, Bin Chen, Junkai Zhang, Ho-kwang Mao, Cailong Liu, Yonghao Han, Zhiqiang Chen, Chunxiao Gao, Feng Ke, Jinsheng Wen, and Jian-Bo Zhang
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musculoskeletal diseases ,Superconductivity ,Materials science ,Room-temperature superconductor ,Condensed matter physics ,Phonon ,Decompression ,Chalcogenide ,Mechanical Engineering ,02 engineering and technology ,Crystal structure ,021001 nanoscience & nanotechnology ,Compression (physics) ,01 natural sciences ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,0103 physical sciences ,General Materials Science ,010306 general physics ,0210 nano-technology ,Softening - Abstract
An unexpected superconductivity enhancement is reported in decompressed In2Se3. The onset of superconductivity in In2Se3 occurs at 41.3 GPa with a critical temperature (Tc) of 3.7 K, peaking at 47.1 GPa. The striking observation shows that this layered chalcogenide remains superconducting in decompression down to 10.7 GPa. More surprisingly, the highest Tc that occurs at lower decompression pressures is 8.2 K, a twofold increase in the same crystal structure as in compression. It is found that the evolution of Tc is driven by the pressure-induced R-3m to I-43d structural transition and significant softening of phonons and gentle variation of carrier concentration combined in the pressure quench. The novel decompression-induced superconductivity enhancement implies that it is possible to maintain pressure-induced superconductivity at lower or even ambient pressures with better superconducting performance.
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- 2017
116. Long non-coding RNA CASC2 regulates cell biological behaviour through the MAPK signalling pathway in hepatocellular carcinoma
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Mei-Xia Zhang, Zhi-Xiong Long, Ximing Xu, Yuan-Yuan Gan, Na-Na Han, Yongfa Zheng, Wei Ge, Jun-Jian Deng, Xiaoqin He, Yujie Zhou, Huiling Liang, and Jia-Jun Yu
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Adult ,Male ,0301 basic medicine ,Carcinoma, Hepatocellular ,Carcinogenesis ,MAP Kinase Signaling System ,Cell ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,medicine ,Humans ,Genes, Tumor Suppressor ,Protein kinase A ,RC254-282 ,Aged ,Cell Proliferation ,Tumor Suppressor Proteins ,Liver Neoplasms ,RNA ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Hep G2 Cells ,General Medicine ,Middle Aged ,medicine.disease ,Hedgehog signaling pathway ,Long non-coding RNA ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,medicine.anatomical_structure ,Apoptosis ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Cancer research ,Female ,RNA, Long Noncoding - Abstract
Long non-coding RNAs have previously been demonstrated to play important roles in regulating human diseases, especially cancer. However, the biological functions and molecular mechanisms of long non-coding RNAs in hepatocellular carcinoma have not been extensively studied. The long non-coding RNA CASC2 (cancer susceptibility candidate 2) has been characterised as a tumour suppressor in endometrial cancer and gliomas. However, the role and function of CASC2 in hepatocellular carcinoma remain unknown. In this study, using quantitative real-time polymerase chain reaction, we confirmed that CASC2 expression was downregulated in 50 hepatocellular carcinoma cases (62%) and in hepatocellular carcinoma cell lines compared with the paired adjacent tissues and normal liver cells. In vitro experiments further demonstrated that overexpressed CASC2 decreased hepatocellular carcinoma cell proliferation, migration and invasion as well as promoted apoptosis via inactivating the mitogen-activated protein kinase signalling pathway. Our findings demonstrate that CASC2 could be a useful tumour suppressor factor and a promising therapeutic target for hepatocellular carcinoma.
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- 2017
117. Decompression-Driven Superconductivity Enhancement in In
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Feng, Ke, Haini, Dong, Yabin, Chen, Jianbo, Zhang, Cailong, Liu, Junkai, Zhang, Yuan, Gan, Yonghao, Han, Zhiqiang, Chen, Chunxiao, Gao, Jinsheng, Wen, Wenge, Yang, Xiao-Jia, Chen, Viktor V, Struzhkin, Ho-Kwang, Mao, and Bin, Chen
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An unexpected superconductivity enhancement is reported in decompressed In
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- 2017
118. Characterization of 6XXX Series Aluminum Extrusions Using Digital Image Correlation (DIC) technique
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Danielle Zeng, Andrey M. Ilinich, Kiran Kumar Mallela, Yuan Gan, and S Luckey
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Digital image correlation ,Materials science ,Optics ,chemistry ,Series (mathematics) ,Aluminium ,business.industry ,chemistry.chemical_element ,business ,Characterization (materials science) - Published
- 2017
119. Spin-Wave Excitations Evidencing the Kitaev Interaction in Single Crystalline α−RuCl3
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J. T. Park, Zhao-Yang Dong, Youtian Zhang, Jinghui Wang, Xiao Ren, Wei Wang, Kejing Ran, Zhen Ma, Shun-Li Yu, Yuan Gan, Song Bao, Shichao Li, Jinsheng Wen, Jian-Xin Li, Guochu Deng, and Sergey Danilkin
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Physics ,Condensed matter physics ,Exchange interaction ,General Physics and Astronomy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Coupling (probability) ,01 natural sciences ,Inelastic neutron scattering ,Brillouin zone ,Spin wave ,0103 physical sciences ,Antiferromagnetism ,Quantum spin liquid ,010306 general physics ,0210 nano-technology ,Energy (signal processing) - Abstract
Kitaev interactions underlying a quantum spin liquid have long been sought, but experimental data from which their strengths can be determined directly, are still lacking. Here, by carrying out inelastic neutron scattering measurements on high-quality single crystals of $\ensuremath{\alpha}\text{\ensuremath{-}}{\mathrm{RuCl}}_{3}$, we observe spin-wave spectra with a gap of $\ensuremath{\sim}2\text{ }\text{ }\mathrm{meV}$ around the $M$ point of the two-dimensional Brillouin zone. We derive an effective-spin model in the strong-coupling limit based on energy bands obtained from first-principles calculations, and find that the anisotropic Kitaev interaction $K$ term and the isotropic antiferromagnetic off-diagonal exchange interaction $\mathrm{\ensuremath{\Gamma}}$ term are significantly larger than the Heisenberg exchange coupling $J$ term. Our experimental data can be well fit using an effective-spin model with $K=\ensuremath{-}6.8\text{ }\text{ }\mathrm{meV}$ and $\mathrm{\ensuremath{\Gamma}}=9.5\text{ }\text{ }\mathrm{meV}$. These results demonstrate explicitly that Kitaev physics is realized in real materials.
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- 2017
120. High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway
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Yuan-Yuan Gan, Jun-Jian Deng, Ximing Xu, Yuefeng Zhang, Yongfa Zheng, Xiaoqin He, Mei-Xia Zhang, Na-Na Han, Wei Ge, and Jia-Jun Yu
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0301 basic medicine ,Adult ,Male ,Carcinoma, Hepatocellular ,Apoptosis ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,medicine ,Gene silencing ,Humans ,Neoplasm Invasiveness ,Neoplasm Metastasis ,Autocrine signalling ,PI3K/AKT/mTOR pathway ,RC254-282 ,Aged ,Cell Proliferation ,Oncogene ,Kinase ,Chemistry ,Cell Cycle ,Liver Neoplasms ,Intracellular Signaling Peptides and Proteins ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,General Medicine ,Hep G2 Cells ,Cell cycle ,Middle Aged ,medicine.disease ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Protein kinase B signaling ,Cancer research ,Female ,Phosphatidylinositol 3-Kinase ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related hepatocellular carcinoma tissues through a hierarchical clustering analysis. With this study, we first assessed the expression pattern of G-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; clinical data were analyzed, along survival times, utilizing the Kaplan–Meier method. Moreover, the functions of G-protein signaling modulator 2 were examined using small-interfering RNAs in vitro. The results showed that G-protein signaling modulator 2 was clearly overexpressed in hepatocellular carcinoma tissues and cell lines and that the G-protein signaling modulator 2 expression level was related to tumor size and hepatitis B virus infection. Furthermore, G-protein signaling modulator 2 knockdown studies suggested that G-protein signaling modulator 2 accelerates cell growth, cell cycle, migration, and invasion and inhibits apoptosis, acting as an oncogene in hepatocellular carcinoma. Western blotting indicated that silencing of G-protein signaling modulator 2 in HepG2 and SMMC-7721 cells increased the expression levels of Bax, caspase-3, and E-cadherin, while notably suppressing the cyclin-dependent kinase 4, cyclin-dependent kinase 6, CyclinD1, Snail1, Vimentin, and matrix metallopeptidase 9 expression levels, compared with that in the control groups. In addition, we found that G-protein signaling modulator 2 can affect the expression of key proteins involved in protein kinase B activation. In conclusion, high expression of G-protein signaling modulator 2 was involved in the pathological processes of hepatocellular carcinoma through activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which may provide an attractive potential diagnostic biomarker and therapeutic target for treatment of hepatocellular carcinoma.
- Published
- 2017
121. 3D Shape Segmentation via Shape Fully Convolutional Networks
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Yan Zhang, Songle Chen, Yuan Gan, Fenggen Yu, Zhengxing Sun, Pengyu Wang, and Panpan Shui
- Subjects
FOS: Computer and information sciences ,Bridging (networking) ,Computer science ,Computer Vision and Pattern Recognition (cs.CV) ,Pooling ,Computer Science - Computer Vision and Pattern Recognition ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,02 engineering and technology ,Cut ,0202 electrical engineering, electronic engineering, information engineering ,Segmentation ,Computer vision ,Architecture ,Network architecture ,business.industry ,General Engineering ,Pattern recognition ,020206 networking & telecommunications ,020207 software engineering ,Image segmentation ,3d shapes ,Computer Graphics and Computer-Aided Design ,Human-Computer Interaction ,020201 artificial intelligence & image processing ,Artificial intelligence ,business - Abstract
We desgin a novel fully convolutional network architecture for shapes, denoted by Shape Fully Convolutional Networks (SFCN). 3D shapes are represented as graph structures in the SFCN architecture, based on novel graph convolution and pooling operations, which are similar to convolution and pooling operations used on images. Meanwhile, to build our SFCN architecture in the original image segmentation fully convolutional network (FCN) architecture, we also design and implement a generating operation} with bridging function. This ensures that the convolution and pooling operation we have designed can be successfully applied in the original FCN architecture. In this paper, we also present a new shape segmentation approach based on SFCN. Furthermore, we allow more general and challenging input, such as mixed datasets of different categories of shapes} which can prove the ability of our generalisation. In our approach, SFCNs are trained triangles-to-triangles by using three low-level geometric features as input. Finally, the feature voting-based multi-label graph cuts is adopted to optimise the segmentation results obtained by SFCN prediction. The experiment results show that our method can effectively learn and predict mixed shape datasets of either similar or different characteristics, and achieve excellent segmentation results., Comment: We update some missing references about intrinsic CNNs (2018.5.24)
- Published
- 2017
- Full Text
- View/download PDF
122. Visualization Study of Dust Dispersion Process in Siwek 20-L Device for Dust Explosion Test
- Author
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Long Liu, Wei Xing Huang, Yi Dan Ren, Nian Sheng Kuai, Yuan Gan, Jing Jie Yuan, and Bing Du
- Subjects
Control valves ,Physics ,Optics ,Transmission (telecommunications) ,business.industry ,Settlement (structural) ,Frame (networking) ,Dispersion (optics) ,Process (computing) ,General Medicine ,business ,Dust explosion ,Visualization - Abstract
A visualization method is proposed in order to characterize the dispersion process of dust cloud in Siwek 20-L explosion device. The visualization system consists of a transparent spherical vessel, a dust dispersion device, a high precision control valve and a high-speed camera. Experiment with wheat flour powder indicate that the non-uniformity of dust cloud in space and time can be clearly distinguished based on the frame pictures, as well as the evolution of particles settlement with time after dispersion. Moreover, qualitative analysis based on picture processing technique was carried out to obtain the transmission data of dust cloud from the frame pictures. Results show that the transmission changes rapidly with time and reaches to the minimum value at about 60 ms after dispersion, and with this time, the optimum ignition delay time can be determined for dust explosion test in Siwek 20-L device.
- Published
- 2014
123. Noninvasive Measurement of Glucose in Artificial Plasma with Near-Infrared and Raman Spectroscopy
- Author
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Xinyu Yan, Guo Huang, Yuan Gan, Jin-Tao Xue, Dong-Mei Xiong, Cong Chen, Han Chen, Hong Ai, Li-Ming Ye, Yan Liang, and Ruobing Chao
- Subjects
Blood Glucose ,Spectroscopy, Near-Infrared ,Chemistry ,Near-infrared spectroscopy ,Plasma Substitutes ,Analytical chemistry ,Reproducibility of Results ,Signal Processing, Computer-Assisted ,Spectrum Analysis, Raman ,Models, Biological ,Sensitivity and Specificity ,Root mean square ,symbols.namesake ,Applied spectroscopy ,Partial least squares regression ,symbols ,Calibration ,Least-Squares Analysis ,Spectroscopy ,Raman spectroscopy ,Instrumentation ,Blood Chemical Analysis ,Raman scattering - Abstract
The goal of this research was to develop a method for noninvasive blood glucose assay. Near-infrared (NIR) spectroscopy and Raman spectroscopy, two more promising techniques compared to other methods, were investigated in two kinds of artificial plasma (AP). Calibration models were generated by performing partial least squares (PLS) regression and optimized individually by considering spectral range, spectral pretreatment methods, and number of model factors. The two spectroscopic models were validated for the determination of glucose, and the results show that the two spectroscopic models established are robust, accurate, and repeatable. Compared to Raman spectroscopy, the performance of NIR spectroscopy was much better, with lower root mean square errors of cross-validation (RMSECV) of 0.128 and 0.094 mg/ml, lower root mean square errors of validation (RMSEP) of 0.061 and 0.046 mg/ml, higher correlation coefficients ( R) of 99.15% and 99.55%, and higher residual predictive deviations (RPD) of 10.8 and 15.0 for artificial plasma I and II, respectively.
- Published
- 2014
124. Prediction and Screening of Biologically Active Compounds in Honeysuckle (Lonicera japonica) by Biopartitioning Micellar Chromatography
- Author
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Yuan Gan, Yan Liang, Han Chen, Jin-Tao Xue, Xin-Yu Yan, Dong-Mei Xiong, Cong Chen, Li-Ming Ye, Ting Xu, and Yu Chen
- Subjects
General Chemistry - Published
- 2014
125. Spin-Wave Excitations Evidencing the Kitaev Interaction in Single Crystalline α-RuCl_{3}
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Kejing, Ran, Jinghui, Wang, Wei, Wang, Zhao-Yang, Dong, Xiao, Ren, Song, Bao, Shichao, Li, Zhen, Ma, Yuan, Gan, Youtian, Zhang, J T, Park, Guochu, Deng, S, Danilkin, Shun-Li, Yu, Jian-Xin, Li, and Jinsheng, Wen
- Abstract
Kitaev interactions underlying a quantum spin liquid have long been sought, but experimental data from which their strengths can be determined directly, are still lacking. Here, by carrying out inelastic neutron scattering measurements on high-quality single crystals of α-RuCl_{3}, we observe spin-wave spectra with a gap of ∼2 meV around the M point of the two-dimensional Brillouin zone. We derive an effective-spin model in the strong-coupling limit based on energy bands obtained from first-principles calculations, and find that the anisotropic Kitaev interaction K term and the isotropic antiferromagnetic off-diagonal exchange interaction Γ term are significantly larger than the Heisenberg exchange coupling J term. Our experimental data can be well fit using an effective-spin model with K=-6.8 meV and Γ=9.5 meV. These results demonstrate explicitly that Kitaev physics is realized in real materials.
- Published
- 2016
126. RNA-seq transcriptome profiling of porcine lung from two pig breeds in response to Mycoplasma hyopneumoniae infection
- Author
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Xinsheng Wu, Yuan Gan, Zhao Xuting, Xiaoyan Wang, Bichun Li, Chengyi Song, and Ligang Ni
- Subjects
Candidate gene ,Duroc pig ,lcsh:Medicine ,RNA-Seq ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Andrology ,03 medical and health sciences ,Immune system ,Mycoplasma hyopneumoniae ,KEGG ,Gene ,030304 developmental biology ,0303 health sciences ,General Neuroscience ,lcsh:R ,030302 biochemistry & molecular biology ,General Medicine ,biology.organism_classification ,Breed ,Real-time polymerase chain reaction ,Jiangquhai pig ,RNA-seq ,General Agricultural and Biological Sciences - Abstract
Background Mycoplasma hyopneumoniae (Mhp) is the main pathogen causing respiratory disease in the swine industry. Mhp infection rates differ across pig breeds, with Chinese native pig breeds that exhibit high fecundity (e.g., Jiangquhai, Meishan, Erhualian) more sensitive than Duroc, Landrace, and other imported pig breeds. However, the genetic basis of the immune response to Mhp infection in different pig breeds is largely unknown. Aims The aims of this study were to determine the relative Mhp susceptibility of the Chinese native Jiangquhai breed compared to the Duroc breed, and identify molecular mechanisms of differentially expressed genes (DEGs) using an RNA-sequencing (RNA-seq) approach. Methods Jiangquhai and Duroc pigs were artificially infected with the same Mhp dose. The entire experiment lasted 28 days. Daily weight gain, Mhp-specific antibody levels, and lung lesion scores were measured to evaluate the Mhp infection susceptibility of different breeds. Experimental pigs were slaughtered on the 28th day. Lung tissues were collected for total RNA extraction. RNA-seq was performed to identify DEGs, which were enriched by gene ontology (GO) and the Kyoto Encyclopedia annotation of Genes and Genomes (KEGG) databases. DEGs were validated with real-time quantitative polymerase chain reaction (RT-qPCR). Results Infection with the same Mhp dose produced a more serious condition in Jiangquhai pigs than in Duroc pigs. Jiangquhai pigs showed poorer growth, higher Mhp antibody levels, and more serious lung lesions compared with Duroc pigs. RNA-seq identified 2,250 and 3,526 DEGs in lung tissue from Jiangquhai and Duroc pigs, respectively. The two breeds shared 1,669 DEGs, which were involved in immune-relevant pathways including cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, and chemokine signaling pathway. Compared to Jiangquhai pigs, more chemokines, interferon response factors, and interleukins were specifically activated in Duroc pigs; CXCL10, CCL4, IL6 and IFNG genes were significantly up-regulated, which may help Duroc pigs enhance immune response and reduce Mhp susceptibility. Conclusion This study demonstrated differential immune-related DEGs in lung tissue from the two breeds, and revealed an important role of genetics in the immune response to Mhp infection. The biological functions of these important DEGs should be further confirmed and maybe applied as molecular markers that improve pig health.
- Published
- 2019
127. A Condition-Based Maintenance Policy (CBM) of Repairable Multi-Component Deteriorating Systems Based on Quality Information
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Nai-Fei Ren, Shu-Yuan Gan, and Yu Wang
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021110 strategic, defence & security studies ,021103 operations research ,General Computer Science ,Computer science ,Condition-based maintenance ,0211 other engineering and technologies ,Energy Engineering and Power Technology ,Aerospace Engineering ,02 engineering and technology ,Industrial and Manufacturing Engineering ,Reliability engineering ,Nuclear Energy and Engineering ,Component (UML) ,Production (economics) ,Electrical and Electronic Engineering ,Safety, Risk, Reliability and Quality ,Quality information ,Decision analysis - Abstract
The maintenance decision analysis of equipment has always been one of the hot spots of concern for researchers. A maintenance policy for parallel production systems is investigated in this study, with the parallel components having equal cost parameters. The rejection rate indicates the degradation degree of the machine, and the rejection rate is assumed to be obtained by detection. The maintenance strategy proposed in this paper involves two threshold values. By optimizing with genetic algorithm, the threshold values [Formula: see text] and [Formula: see text] corresponding to the minimum expected total cost can be found. Finally, the result of sensitivity analysis is shown that the cost parameter has a great influence on the threshold values.
- Published
- 2019
128. Quasi-2D superconductivity in FeTe0.55Se0.45 ultrathin film
- Author
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Mingquan He, Wei Zhang, G. D. Gu, Peipei Wang, Fangdong Tang, Yuan Gan, Peng Wang, and Liyuan Zhang
- Subjects
Superconductivity ,Materials science ,Condensed matter physics ,Transition temperature ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Coherence length ,MAJORANA ,Electrical resistivity and conductivity ,Condensed Matter::Superconductivity ,0103 physical sciences ,Bound state ,General Materials Science ,Thin film ,010306 general physics ,0210 nano-technology ,Anisotropy - Abstract
Iron-chalcogenide FeTe0.55Se0.45 was found to be a promising topological superconducting candidate recently, which may host Majorana bound state in the vortex core and thus attracts intensive research interests in this material. In this report, mechanically exfoliated FeTe0.55Se0.45 superconducting thin films close to the two-dimensional (2D) limit, i.e. sample thickness is on the order of coherence length, were studied systematically by means of electrical transport and point-contact Andreev-reflection spectroscopy (PCARS) measurements. The quasi-2D nature of FeTe0.55Se0.45 thin films is evidenced by the observation of Berezinskii-Kosterlitz-Thouless (BKT) transition and anisotropic upper critical fields in the vicinity of superconducting transition. Compared to bulk samples, we found that the superconducting transition temperature is only slightly suppressed even for films down to 5 nm. The superconducting gap symmetry remains unchanged and the gap size is weakly affected by tailoring thickness. Our findings suggest that the superconductivity of FeTe0.55Se0.45 thin films is rather robust against reduced dimensions. It provides a novel platform for device applications for quantum computations in combination with possible realization of Majorana modes in this material.
- Published
- 2019
129. Design and Performance Investigation of a Carbon‐Free Pt/Ti Cathode with Low Membrane Degradation Rate for Proton Exchange Membrane Water Electrolyser
- Author
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Lili Guo, Yan Shi, Tan Hongyi, Lu Zhuoxin, Chang-Feng Yan, Wang Zhida, Changqing Guo, and Yuan Gan
- Subjects
Membrane degradation ,General Energy ,Materials science ,chemistry ,Chemical engineering ,law ,Proton exchange membrane fuel cell ,chemistry.chemical_element ,Carbon ,Cathode ,law.invention - Published
- 2019
130. Photodetectors: Ultrahigh-Sensitive Broadband Photodetectors Based on Dielectric Shielded MoTe2 /Graphene/SnS2 p-g-n Junctions (Adv. Mater. 6/2019)
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Rui Chen, Peng Wang, Peipei Wang, Liyuan Zhang, Fangdong Tang, Tailei Qi, Youpin Gong, Yuan Gan, Qianxue Chen, Alei Li, and Judy Z. Wu
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Van der waals heterostructures ,Materials science ,business.industry ,Graphene ,Mechanical Engineering ,Photodetector ,Dielectric ,law.invention ,Mechanics of Materials ,law ,Broadband ,Shielded cable ,Optoelectronics ,General Materials Science ,business - Published
- 2019
131. Ultrahigh‐Sensitive Broadband Photodetectors Based on Dielectric Shielded MoTe 2 /Graphene/SnS 2 p–g–n Junctions
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Youpin Gong, Yuan Gan, Qianxue Chen, Liyuan Zhang, Rui Chen, Judy Z. Wu, Alei Li, Peipei Wang, Peng Wang, Tailei Qi, and Fangdong Tang
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Materials science ,business.industry ,Graphene ,Mechanical Engineering ,Photodetector ,Heterojunction ,02 engineering and technology ,Photodetection ,Specific detectivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Responsivity ,Semiconductor ,Mechanics of Materials ,law ,Optoelectronics ,General Materials Science ,Photonics ,0210 nano-technology ,business - Abstract
2D atomic sheets of transition metal dichalcogenides (TMDs) have a tremendous potential for next-generation optoelectronics since they can be stacked layer-by-layer to form van der Waals (vdW) heterostructures. This allows not only bypassing difficulties in heteroepitaxy of lattice-mismatched semiconductors of desired functionalities but also providing a scheme to design new optoelectronics that can surpass the fundamental limitations on their conventional semiconductor counterparts. Herein, a novel 2D h-BN/p-MoTe2 /graphene/n-SnS2 /h-BN p-g-n junction, fabricated by a layer-by-layer dry transfer, demonstrates high-sensitivity, broadband photodetection at room temperature. The combination of the MoTe2 and SnS2 of complementary bandgaps, and the graphene interlayer provides a unique vdW heterostructure with a vertical built-in electric field for high-efficiency broadband light absorption, exciton dissociation, and carrier transfer. The graphene interlayer plays a critical role in enhancing sensitivity and broadening the spectral range. An optimized device containing 5-7-layer graphene has been achieved and shows an extraordinary responsivity exceeding 2600 A W-1 with fast photoresponse and specific detectivity up to ≈1013 Jones in the ultraviolet-visible-near-infrared spectrum. This result suggests that the vdW p-g-n junctions containing multiple photoactive TMDs can provide a viable approach toward future ultrahigh-sensitivity and broadband photonic detectors.
- Published
- 2018
132. Corrigendum to '3D shape segmentation via shape fully convolutional networks' [Computers & Graphics 70 (2018) 128–139]
- Author
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Zhengxing Sun, Yan Zhang, Songle Chen, Fenggen Yu, Pengyu Wang, Yuan Gan, and Panpan Shui
- Subjects
Human-Computer Interaction ,Computer science ,Computer graphics (images) ,General Engineering ,Segmentation ,Graphics ,Computer Graphics and Computer-Aided Design - Published
- 2018
133. A self-driven microfluidic surface-enhanced Raman scattering device for Hg2+ detection fabricated by femtosecond laser.
- Author
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Li, Xiuyun, Yuan, Gan, Yu, Weili, Xing, Jun, Zou, Yuting, Zhao, Chen, Kong, Wenchi, Yu, Zhi, and Guo, Chunlei
- Subjects
- *
SERS spectroscopy , *FEMTOSECOND lasers , *RAMAN lasers , *RAMAN scattering , *MICROFLUIDIC devices , *SIGNAL detection , *SURFACE structure - Abstract
In this paper, we proposed a novel approach for rapid and flexible fabrication of self-driven microfluidic surface enhanced Raman scattering (SERS) chips for quantitative analysis of Hg2+ by femtosecond laser direct writing. In contrast to traditional microfluidic chips, the microchannels of the device can drive a liquid sample flow without external driving force. The sample flow speed is tunable since the wettability and capillarity properties of the channels, which depend on the roughness and the inner diameter of the microchannels, can be controlled by optimizing the laser processing parameters. The SERS active detection sites, which exhibit high enhancement effects and fine reproducibility, were integrated through the femtosecond laser-induced periodic surface structures (LIPSS), followed by 30 nm Ag deposition. The SERS performance of the as-prepared microfluidic SERS detection chip was studied with R6G as probe molecules. The quantitative analysis of Hg2+ was realized by simply injecting the Hg2+ sample and the probe molecules R6G from the two inlets, separately, and collecting the SERS signal at the detection site. The lowest detection limit for Hg2+ is 10−9 M. It should be mentioned that this study is not only limited to Hg2+ quantitative analysis, but is also mainly aimed to develop a new technique for the design and fabrication of novel self-driven microfluidic devices depending on practical application requirements. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
134. The Influences of the High-Rise Buildings to Urban Space Morphology in Chongqing
- Author
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Shi Yuan Gan
- Subjects
Pollution ,Geography ,media_common.quotation_subject ,Psychological pressure ,Light pollution ,Environmental engineering ,Identity (social science) ,General Medicine ,Urban space ,Environmental planning ,High rise ,media_common - Abstract
Describes implication of urban space morphology, and analyzes the positive influences of the High-rise Buildings to Chongqing Urban Space Morphology from the aspects of Saving land, Reflecting the characteristics of mountainous city, Making the city has a sense of identity, Making people contacts and exchanges more convenient, Relieving the psychological pressure of people properly, and Analyzes The Negative Influences from the aspects of Physical, Social and Psychological Influences, particularly, the Light Pollution, Wind environment Pollution, acoustic Environment Pollution and Thermal environment influence of physical aspects, and The Influences on urban transport, urban space and the safety of social aspects.
- Published
- 2013
135. Experiment-based investigations on the effect of ignition energy on dust explosion behaviors
- Author
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Niansheng Kuai, Bing Du, Zongshan Li, Weixing Huang, Yuan Gan, Jingyi Tan, and Jingjie Yuan
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Materials science ,Waste management ,General Chemical Engineering ,Energy Engineering and Power Technology ,Mechanics ,Management Science and Operations Research ,IGNITOR ,Kinetic energy ,Combustion ,Industrial and Manufacturing Engineering ,Light metal ,law.invention ,Ignition system ,Control and Systems Engineering ,law ,Safety, Risk, Reliability and Quality ,Dust explosion ,Food Science ,Dimensionless quantity ,Flammability limit - Abstract
Explosion behaviors of typical light metal and carbonaceous dusts induced by different ignition energies were investigated based on systematic experiments in a Siwek 20 L vessel. Comparative analysis reveals that the explosion mechanism of carbonaceous dust is the volatile combustion, whereas the mechanism for light metal dust mainly features the surface heterogeneous oxidation. Influences of ignition energy on severity and flammability limit are much more significant for carbonaceous dust than light metal, especially for the powder with less volatile. An innovative approach was introduced to derive flame thickness from the pressure–time trace. The relation between explosion induction time and combustion duration of ignitor was also analyzed. Results show inappropriate ignition energy will cause under-/over-driving in the thermodynamic/kinetic characteristic measurements. In this way, a dimensionless parameter pressure ratio was introduced to evaluate the under-driving, while two methods by using flame thickness and induction time respectively, were proposed to evaluate over-driving. To improve the accuracy of dust explosion tests, authors advocate that explosion severity determination should be conducted at the critical ignition energy. Moreover, a comparison between the European and Chinese flammability limit determination procedures was also conducted, indicating that EN 14034-3 is suitable for light metal but not for carbonaceous, while GB/T 16425 appears to be slightly conservative for both carbonaceous and light metal dusts.
- Published
- 2013
136. Ring-Space Array Torque Measure System and Signal Singularity Detection
- Author
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Yuan Gan Wang
- Subjects
Mechanical system ,Singularity ,Noise (signal processing) ,Control theory ,Frequency domain ,General Engineering ,Wavelet transform ,Torque ,Signal ,Mathematics ,Principal axis theorem - Abstract
Torque is the most important dynamic characteristics of the mechanically-driven system. In order to monitor the mechanical principal axis in real time, a new non-contact torque measurement system based on ring-space array sensor is proposed. This system can be used for the analysis of dynamic characteristics of the mechanical system’s axis under various loads and hard working environments. Singularity in the collected signals is most important with the mechanical system. Because of much noise was contained in collected signals, which always interferes the signal’s singularity detection. According to the different behaves of signal and noise under wavelet transform, a method with wavelet filtering and singularity detection combined is proposed. This method could realize two-dimension filtering reconstruction in both time and frequency domain, in which the singularity information in signal can be kept well while the noise will be filtered. The proposed method is suitable for singularity detection of signals under serious noise.
- Published
- 2012
137. An automatic radio monitoring and early warning architecture based on C/S for illegal broadcasting
- Author
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Hao Yuan Gan, Qian Nan Lu, Ming Huang, Jing Jing Yang, and Mei Xia Yang
- Subjects
Warning system ,Computer science ,business.industry ,020208 electrical & electronic engineering ,Real-time computing ,02 engineering and technology ,Broadcasting ,Communications system ,computer.software_genre ,Radio spectrum ,law.invention ,law ,Sensor node ,Internet Protocol ,0202 electrical engineering, electronic engineering, information engineering ,Web service ,business ,computer ,Windows Presentation Foundation - Abstract
Current radio spectrum monitoring systems are “man-machine” communication systems based on Radio Monitoring Transfer Protocol (RMTP), which are unable to detect and process the radio interference automatically. In this paper an automatic radio monitoring and early warning architecture based on C/S model and internet protocol is proposed. A pilot “machine-machine” system which consists of several sensor nodes and an application & service (A&S) center for monitoring and early warning to illegal broadcasting is implemented using Baidu map JavaScript API technology and Windows Presentation Foundation (WPF). The sensor node is a RTL-SDR connected to an industrial computer. It mainly takes charge of illegal signal detection, early warning and monitoring data storing. What's more it provides a web service for the A&S center to retrieve the monitoring data in a fixed time interval for further data presentation and statistical analysis.
- Published
- 2016
138. Improved cubature Kalman filtering for tightly coupled GPS/SINS integrated navigation system
- Author
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Yuan Gan-nan, Wang Wei, and Zhu Wei
- Subjects
0209 industrial biotechnology ,Engineering ,business.industry ,Navigation system ,020206 networking & telecommunications ,02 engineering and technology ,Kalman filter ,Simultaneous localization and mapping ,Invariant extended Kalman filter ,Extended Kalman filter ,020901 industrial engineering & automation ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Fast Kalman filter ,Unscented transform ,business ,Alpha beta filter - Abstract
In the integrated navigation system, unscented Kalman filter (UKF) has been widely used. Compared to traditional Kalman filter and extended Kalman filter, the UKF algorithm has improved in accuracy than Kalman filter. However, UKF has no strict mathematical proof, and when the order of the system increases, the error of UKF becomes larger, even cause divergence. In this paper higher order cubature Kalman filter is introduce in GPS/SINS tightly coupled navigation system to improve the accuracy and stability. And the accuracy of higher order cubature Kalman filter and UKF are analysed through Taylor expansion in this paper, which proved higher order cubature Kalman filter performs better than UKF in mathematics. The simulation results show that the improved cubature Kalman filter can effectively improve the navigation system's accuracy and stability.
- Published
- 2016
139. Schizophrenia Spectrum Disorders Show Reduced Specificity and Less Positive Events in Mental Time Travel
- Author
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Antao Chen, Xing-jie Chen, Ya Wang, Raymond C.K. Chan, Ming-yuan Gan, Chun-Qiu Li, David Shum, Fenghua Li, Ji-fang Cui, Wei-hong Wang, Lu-lu Liu, and Han-feng Zheng
- Subjects
medicine.medical_specialty ,Chronesthesia ,lcsh:BF1-990 ,schizophrenia spectrum ,episodic future thinking ,050105 experimental psychology ,Sentence completion tests ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,medicine ,Psychology ,0501 psychology and cognitive sciences ,mental time travel ,Psychiatry ,past ,General Psychology ,Original Research ,Recall ,05 social sciences ,Cognition ,medicine.disease ,Schizotypal personality disorder ,schizophrenia ,lcsh:Psychology ,Schizophrenia ,Personal experience ,030217 neurology & neurosurgery ,Schizophrenia spectrum - Abstract
Mental time travel refers to the ability to recall past events and to imagine possible future events. Schizophrenia patients have problems in remembering specific personal experiences in the past and imagining what will happen in the future. This study aimed to examine episodic past and future thinking in schizophrenia spectrum disorders including schizophrenia patients and individuals with schizotypal personality disorder (SPD) proneness who are at risk for developing schizophrenia. Thirty-two schizophrenia patients, 30 SPD proneness individuals, and 33 healthy controls participated in the study. The Sentence Completion for Events from the Past Test (SCEPT) and the Sentence Completion for Events in the Future Test (SCEFT) were used to measure past and future thinking abilities. Results showed that schizophrenia patients showed significantly reduced specificity in recalling past and imagining future events, they generated less proportion of specific and extended events compared to healthy controls. SPD proneness individuals only generated less extended events compared to healthy controls. The reduced specificity was mainly manifested in imagining future events. Both schizophrenia patients and SPD proneness individuals generated less positive events than controls. These results suggest that mental time travel impairments in schizophrenia spectrum disorders and have implications for understanding their cognitive and emotional deficits.
- Published
- 2016
140. Real-space characterization of reactivity towards water at theBi2Te3(111) surface
- Author
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Zhen-Yu Jia, Shichao Li, Ding Ding, Ye-Heng Song, Chao-Long Yang, Kai-Wen Zhang, Shao-Chun Li, Zihua Zhu, Yuan Gan, Mingshu Chen, Wen-Kai Huang, Jinsheng Wen, and Xiang-Bing Li
- Subjects
Physics ,Surface (mathematics) ,Reaction mechanism ,Surface reactivity ,02 engineering and technology ,Characterization (mathematics) ,021001 nanoscience & nanotechnology ,Space (mathematics) ,01 natural sciences ,law.invention ,Crystallography ,Nuclear magnetic resonance ,law ,Topological insulator ,0103 physical sciences ,Reactivity (chemistry) ,Scanning tunneling microscope ,010306 general physics ,0210 nano-technology - Abstract
Surface reactivity is important in modifying the physical and chemical properties of surface-sensitive materials, such as the topological insulators. Even though many studies addressing the reactivity of topological insulators towards external gases have been reported, it is still under heavy debate whether and how the topological insulators react with ${\mathrm{H}}_{2}\mathrm{O}$. Here, we employ scanning tunneling microscopy to directly probe the surface reaction of $\mathrm{B}{\mathrm{i}}_{2}\mathrm{T}{\mathrm{e}}_{3}$ towards ${\mathrm{H}}_{2}\mathrm{O}$. Surprisingly, it is found that only the top quintuple layer is reactive to ${\mathrm{H}}_{2}\mathrm{O}$, resulting in a hydrated Bi bilayer as well as some Bi islands, which passivate the surface and prevent subsequent reaction. A reaction mechanism is proposed with ${\mathrm{H}}_{2}\mathrm{Te}$ and hydrated Bi as the products. Unexpectedly, our study indicates that the reaction with water is intrinsic and not dependent on any surface defects. Since water inevitably exists, these findings provide key information when considering the reactions of $\mathrm{B}{\mathrm{i}}_{2}\mathrm{T}{\mathrm{e}}_{3}$ with residual gases or atmosphere.
- Published
- 2016
141. The effect and mechanisms of implementation intention in improving prospective memory performance in schizophrenia patients
- Author
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David L. Neumann, Ming-yuan Gan, Chun-Qiu Li, Xing-jie Chen, Ji-fang Cui, Lu-lu Liu, David Shum, Ya Wang, and Raymond C.K. Chan
- Subjects
Adult ,Male ,Memory, Episodic ,Intention ,050105 experimental psychology ,Task (project management) ,Developmental psychology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Prospective memory ,medicine ,Reaction Time ,Humans ,0501 psychology and cognitive sciences ,Biological Psychiatry ,Memory Disorders ,Implementation intention ,05 social sciences ,medicine.disease ,Psychiatry and Mental health ,Schizophrenia ,Mental Recall ,Female ,Schizophrenic Psychology ,Psychology ,030217 neurology & neurosurgery ,Cognitive load ,Psychomotor Performance ,Clinical psychology - Abstract
People with schizophrenia (SCZ) have been shown to have prospective memory (PM) deficits. PM refers to the ability to remember to perform delayed intentions in the future and plays an important role in everyday independent functioning in SCZ. To date, few studies have investigated methods to improve PM in SCZ. This study aimed to examine whether implementation intention can improve PM performance and to explore its underlying mechanisms. Fifty people with SCZ and 50 demographically matched healthy controls (HC) participated in this study. Participants were randomly assigned to an implementation intention condition or a control instruction condition. Participants were required to make PM responses when PM cue words appeared while they were undertaking an ongoing task with two levels of cognitive load (1-back or 2-back). Results showed that people with SCZ were impaired in PM, and implementation intention improved PM performances for both SCZ and HC. Implementation intention improved PM performance in SCZ in both the low and the high cognitive load conditions without ongoing task cost, suggesting that implementation intention improved PM remembering in an automatic way. These results indicate that implementation intention may be a beneficial technique for improving PM performances in people with SCZ.
- Published
- 2016
142. Research on the Optimal Design of Soccer Robot based on the Mechanical Analysis
- Author
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Hao-yuan Gan and Na Dong
- Subjects
Reduction (complexity) ,Optimal design ,Engineering ,Local optimum ,Coverage ratio ,business.industry ,Numerical analysis ,Process (computing) ,business ,Wireless sensor network ,Algorithm ,Simulation ,Soccer robot - Abstract
Aiming at the high complexity and low coverage ratio of existing coverage enhancing algorithms in directional wireless sensor network, a coverage enhancing algorithm based on numerical analysis and greedy iteration is proposed. The proposed algorithm adjusts the sensor direction by way of greedy iteration, until all sensor directions reach local optimum. Meanwhile, in the process of greedy iteration, greedy iteration is used to simplify the area calculation to reach the reduction of the complexity of the proposed algorithm. The simulation demonstrates that the proposed algorithm is well convergent with high coverage rate and medium execution time.
- Published
- 2016
143. Dermal bioactives from lactobacilli and bifidobacteria
- Author
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Lee-Ching Lew, Chee-Yuan Gan, and Min-Tze Liong
- Subjects
Bifidobacterium longum ,food and beverages ,Biology ,biology.organism_classification ,digestive system ,Applied Microbiology and Biotechnology ,Diacetyl ,Lactic acid ,Microbiology ,chemistry.chemical_compound ,Acetic acid ,fluids and secretions ,chemistry ,Lactobacillus rhamnosus ,Fermentation ,Peptidoglycan ,Lipoteichoic acid - Abstract
Lactobacilli and bifidobacteria are the most common genera of probiotics with documented potentials on gut health. Recent studies have suggested that such potentials can be extended beyond gut well-being, such as that of dermal health. Our present study aimed to evaluate the production of bioactives that are essential for skin defense, such as lipoteichoic acid, peptidoglycan, hyaluronic acid, sphingomyelinase, lactic acid, acetic acid, and diacetyl, from lactobacilli and bifidobacteria grown in milk. All strains studied showed the presence of LTA in the cell wall fraction, with higher amounts from Lactobacillus rhamnosus FTDC 8313 and Bifidobacterium longum BL 8643 than other strains studied. Meanwhile, all strains studied showed equal concentrations of cell wall peptidoglycan. Our results showed that all strains studied were capable of producing hyaluronic acid, with higher production by lactobacilli than bifidobacteria. Production of diacetyl was more prevalent from strains of lactobacilli, while bifidobacteria produced higher amounts of acetic acid. Strains of lactobacilli and bifidobacteria studied also produced acid and neutral sphingomyelinase, an enzyme that generates ceramides and subsequent development of physical barriers in the stratum corneum. Our current findings show that bioactive and inhibitive extracts are produced from the fermentation of lactobacilli and bifidobacteria in milk, with potentials for dermal applications.
- Published
- 2012
144. Cellular Tolerance, Accumulation and Distribution of Cadmium in Leaves of Hyperaccumulator Picris divaricata
- Author
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Ye-Tao Tang, Quan-Fang Zhang, Yuan-Yuan Gan, Peng-Jie Hu, Nan Yao, Dan Jiang, and Rongliang Qiu
- Subjects
Cadmium ,biology ,Epidermis (botany) ,Soil Science ,chemistry.chemical_element ,Vacuole ,Protoplast ,biology.organism_classification ,Vascular bundle ,Molecular biology ,chemistry ,Picris ,Shoot ,Botany ,Hyperaccumulator - Abstract
Knowledge of cellular metal homeostasis will provide a better understanding of the mechanisms involved in metal tolerance and hyperaccumulation in metal-hyperaccumulating plants. Energy dispersive X-ray spectrometry (EDS) was used to determine the localization of cadmium (Cd) in leaves of the Zn/Cd hyperaccumulator Picris divaricata which had a shoot Cd concentration of 565 mg kg−1 after 2 weeks of growth in solution culture supplying 10 mol L−1 CdCl2. The results indicated that Cd was distributed mainly in the trichomes, upper and lower epidermis and bundle sheath cells, with a relatively low level of Cd in mesophyll cells. Mesophyll protoplasts isolated from leaves remained viable after 24 h exposure to CdCl2 at a concentration up to 1 mmol L−1, indicating their high tolerance to Cd. The intracellular Cd was visualized by staining with Leadmium Green dye, a cellular permeable Cd fluorescence probe. The results showed that the majority of protoplasts (> 82%) did not accumulate Cd, with only a minority (< 18%) showing Cd accumulation. In the Cd-accumulating protoplasts, Cd accumulation was depressed by the addition of Fe2+, Mn2+ and the metabolic inhibitor carbonyl cyanide m-chlorophenylhydrazone (CCCP), but not by Ca2+ or Zn2+. Furthermore, the entire process of Cd uptake from external solution into the cytoplasm and subsequent sequestration into vacuoles was successfully recorded by confocal images. These results suggested that reduced cellular Cd accumulation and efficient Cd vacuolar sequestration in mesophyll cells might be responsible for cellular Cd tolerance and distribution in the leaves of P. divaricata.
- Published
- 2012
145. The Exterior Space Design of Public Rental Housing in Mountainous City of Chongqing
- Author
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Shi Yuan Gan and Wei Zhang
- Subjects
Architectural engineering ,Identification (information) ,Geography ,business.industry ,Living environment ,Distribution (economics) ,Terrain ,General Medicine ,Rental housing ,Space (commercial competition) ,business ,Civil engineering ,Exterior space - Abstract
The Public Rental Housing has been built large-scale ,it doing well in these respect in Chongqing ,such as balanced distribution ,convenience transportation, perfect mating, suitable living environment .But as a real mountainous city ,Public Rental Housing in Chongqing exist some problem in the incorporation between the exterior space and the geographical environment of mountainous city .The exterior space design didn't reflect the characteristic of mountainous city, it also lack of 3d stereo feeling, space distribution lack of identification feeling and characteristic , the acquaintance with special ground feature is not enough .Aim at above problems, come up with reasonable solution to increase the exterior space characteristic of public rental housing exterior space. Such as choosing the suitable living location, compiling with terrain, connecting ground in a suitable way, using various design way and so on.
- Published
- 2012
146. Experimental Investigation on Inerting Mechanism of Dust Explosion
- Author
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Weixing Huang, Jingjie Yuan, Niansheng Kuai, Bing Du, Zongshan Li, and Yuan Gan
- Subjects
Bituminous coal ,Waste management ,Moisture ,business.industry ,geology.rock_type ,Anthracite ,geology ,Poison control ,General Medicine ,Coal dust ,complex mixtures ,respiratory tract diseases ,Deflagration ,Environmental science ,Coal ,business ,Dust explosion ,Engineering(all) - Abstract
Systematic experiments were carried out on explosions of coal dust-inertant mixtures. Explosion severity was gained by using Siwek 20 L vessel and factors strongly influencing inerting effectiveness, such as deflagration mechanism and inertant composition were taken into account. Tests of thermal-gravimetric analysis were conducted to identify the reaction mechanism of coal dust explosions. As a result, bituminous coal dust deflagrates via the homogeneous mechanism, while anthracite dust mainly features the mechanism of heterogeneous reaction. Results reveal that the inerting functional mechanisms are quite different for bituminous coal and anthracite dusts, and the homogeneous-combustion-dust is much easier to be inhibited than the heterogeneous-reaction-dust. Trends of higher inerting effectiveness are associated with better decomposability, more excellent performance of oxygen blocking. Moreover, the particular efficacy of free ammonia decomposed from monoammonium phosphate in flame extinguishing is identified. Added water shows the best inerting effectives due to particle aggregation induced by moisture, which gives the idea that humidification for coal dust is therefore a cost-effective approach for explosion prevention and mitigation.
- Published
- 2012
147. SU43. The Effect of Implementation Intention on Different Types of Prospective Memory Performance in Patients With Schizophrenia
- Author
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Raymond C.K. Chan, Ya Wang, Lu-lu Liu, David Shum, Ming-yuan Gan, and Shuping Tan
- Subjects
Abstracts ,Psychiatry and Mental health ,medicine.medical_specialty ,Implementation intention ,Schizophrenia (object-oriented programming) ,Prospective memory ,medicine ,In patient ,Psychiatry ,Psychology ,Clinical psychology - Abstract
Background: Prospective memory (PM) refers to remembering to execute a planned intention in the future, which can been divided as event-based PM (focal, nonfocal) and time-based PM according to the nature of the cue. Focal event-based PM, where the ongoing task requires processing of the characteristics of PM cues, has been found to be benefited from implementation intention (II, ie, an encoding strategy in the format of “if I see X, then I will do Y”). However, to date, it is unclear whether implementation intention can produce a positive effect on nonfocal event-based PM (where the ongoing task is irrelevant with the PM cues) and time-based PM. Moreover, patients with schizophrenia (SCZ) were found to have impairments in these types of PM, and few studies have been conducted to examine the effect of II on these types of PM. This study investigated whether (and how) implementation intention can improve nonfocal event-based PM and time-based PM performance in patients with SCZ.
- Published
- 2017
148. Time Delay Model of Fractional Fourier Transform and the Application in Signal Filtering
- Author
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Yuan Gan Wang, Hong Lin Yu, and Xin Yu Liang
- Subjects
Non-uniform discrete Fourier transform ,Frequency domain ,Electronic engineering ,Short-time Fourier transform ,Spectral density estimation ,General Medicine ,Harmonic wavelet transform ,Algorithm ,Constant Q transform ,Fractional Fourier transform ,Discrete Fourier transform ,Mathematics - Abstract
Various frequency bands of noises are contained in the actual signal. And it's difficult to eliminate the noise portion, which has a time delay and same spectrum with the original signal with conventional filtering methods. Based on the time delay and the multiplication delay characteristics of the fractional Fourier transform (FRFT), we put forward a FRFT time delay model, which can increase distance between the signal and the noise component. Through corresponding Fractional Fourier Transform to noise-containing signal, the distance between the signal and common frequency noises can be constantly increased within the transform domain, thus easily separating the noise component. The algorithm of the model can be simply deduced, easy realized and converged fast. In the experiment, we simulated the separating characteristics of the transform, and used the method to de-noise the grating signal. Compared with other traditional methods, we find that the FRFT acquired a better result.
- Published
- 2011
149. Ordered Pt Nanopattern Catalysts through Self-Assembled Block Copolymer Template
- Author
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Yuan Gan, Changfeng Yan, and Zhida Wang
- Abstract
Patterning of metallic nanoparticles (NPs) via BC micelles plays an important role in the manufacture of conductive integrated devices. BCs containing a metal-binding block of poly(vinylpyridine) (P2VP or P4VP) can be used as a direct chemical reagent to coordinate to or to be protonated by metal ions and compounds such as chloroplatinic acid (H2PtCl6) or auric acid (HAuCl4). In this work, Platinum nanoparticles (Pt NPs) were synthesized by dip-coated technique on titanium wafers. The dip-coating withdrawal rate and concentration of H2PtCl6 precursor had been investigated as two of most important factors on the morphology of Pt-NP arrays. The result shows that diameter of nanodots decreases with the increase of withdrawal rate. The initial ECSA and durability of the Pt/Ti catalysts, with an initial ECSA of 106.5 m2.g-1 and a nearly zero particle-aggregation during 3000-cycle CV, can be controlled through particle size and spacing.
- Published
- 2018
150. Expression and significance of tumor drug resistance related proteins and beta-catenin in esophageal squamous cell carcinoma
- Author
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Si-Yuan Gan, Xue-Yun Zhong, Su-Mei Li, Hui Peng, Feng Luo, and Si-ming Xie
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Esophageal Neoplasms ,Drug resistance ,medicine.disease_cause ,Young Adult ,Internal medicine ,Carcinoma ,Humans ,Medicine ,Neoplasm Invasiveness ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,beta Catenin ,Aged ,Aged, 80 and over ,Tissue microarray ,business.industry ,Cell Differentiation ,Middle Aged ,medicine.disease ,Multidrug Resistance-Associated Protein 2 ,digestive system diseases ,Multiple drug resistance ,Serous fluid ,Proto-Oncogene Proteins c-bcl-2 ,Dysplasia ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Cancer research ,Immunohistochemistry ,Female ,Multidrug Resistance-Associated Proteins ,business ,Carcinogenesis - Abstract
BACKGROUND AND OBJECTIVE As chemotherapy is generally used in the clinical treatment of cancer, the problem of multidrug resistance (MDR) of tumors against the chemotherapeutic agents becomes more and more serious. It has been the major cause for the failure of the chemotherapy. We detected the expressions of beta-catenin and tumor drug resistance related proteins, MRP2, P-gp, and Bcl-2, in esophageal squamous cell carcinoma (ESCC) to explore their function and correlation in the occurrence and development of MDR in ESCC. METHODS We used the tissue microarray technique, immunohistochemistry, and image analysis methods to detect the expressions of MRP2, P-gp, beta-catenin, and Bcl-2 proteins and analyze their relationships with clinical data in a ESCC tissue microarray consisting of 582 specimens of ESCC, 294 specimens of normal mucosa, 92 specimens of basal cell hyperplasia, and 87 specimens of dysplasia adjacent to cancer tissue. RESULTS The integral optical density (IOD) of MRP2 and Bcl-2, which was 195.7 +/- 175.9 x 10(3)) and 90.5 +/- 112.5 x 10(3)), respectively, was significantly higher in ESCC than in normal mucosa, which was 104.8 +/- 86.1 x103) and 25.2 +/- 46.6 x 10(3)), respectively (P < 0.01). The IOD of P-gp and beta-catenin, which was 57.7 +/- 75.5 x 10(3)) and 32.0 +/- 47.0 x 10(3)) respectively, was significantly lower in ESCC than in normal mucosa, which was 114.8 +/- 106.6 x 10(3)) and 46.1 +/- 35.7 x 10(3)), respectively (P < 0.01). According to the following order, well differentiated moderately differentiated poorly differentiated, the IOD of MRP2 increased in ESCC (P < 0.01). The IOD of beta-catenin was higher in poorly differentiated ESCC than in well or moderately differentiated ESCC (P < 0.01). The IOD of Bcl-2 was lower in well differentiated ESCC than in poorly and moderately differentiated ESCC (P < 0.01). The IOD of beta-catenin and Bcl-2 was higher in the ESCC of specimens with infiltration depths that were in membrane mucosa than those in the muscular layer or serous coat (P < 0.01). The IOD of Bcl-2 was significantly higher in cases with lymph node metastasis than in cases without (P < 0.01). Positive correlations which were respectively between the expressions of P-gp and MRP2, the expressions of P-gp and Bcl-2 were found (r = 0.288 and r = 0.253, respectively, P < 0.01). CONCLUSIONS MRP2, P-gp, and Bcl-2 may be taken as prognostic factors for MDR of ESCC. beta-catenin may play an important role in carcinogenesis and progression of ESCC.
- Published
- 2010
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